615 results match your criteria Journal of Immunotoxicology [Journal]


Detection and quantification of VEGFR-1 in the nuclei of tumor cells by a new flow cytometry-based method.

J Immunotoxicol 2019 Dec;16(1):74-81

a Laboratory of Experimental Diagnostics and Biotherapy of Tumors, Research Institute of Experimental Diagnostics and Therapy of Tumors, N. N. Blokhin National Medical Research Center of Oncology , Ministry of Health of Russia , Moscow , Russia.

Flow cytometry using fluorescent antibodies (FC) is the method of choice for the quantitation of proteins expressed at the surface or inside the cell, but, however, does not allow to selectively measure nuclear expression. We therefore sought to develop a method for the extraction of intact cell nuclei, which can be used for their subsequent immunofluorescent analysis by FC. The studied protein was vascular endothelial growth factor-receptor-type 1 (VEGFR-1) which is important in tumor survival and metastasis. Read More

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http://dx.doi.org/10.1080/1547691X.2019.1598522DOI Listing
December 2019
4 Reads

Toxicity of silver nanoparticles in mouse bone marrow-derived dendritic cells: Implications for phenotype.

J Immunotoxicol 2019 Apr 2:1-9. Epub 2019 Apr 2.

g Department of Physical Chemistry, Center of Nanoscience and Nanotechnology , Ensenada B.C. , Mexico.

Silver nanoparticles (AgNP) are one of the most studied nanoparticles due to their anti-bacterial, -fungal, -viral, -parasitic, and -inflammatory properties. This raises the need to evaluate the toxicity and biological effects of AgNP in the immune system in order to develop new safer biomedical products. In this study, an AgNP formulation currently approved for veterinary applications was applied to mouse bone marrow-derived dendritic cells (BMDC), considered important antigen-presenting cells of the immune system, to evaluate cytotoxicity, genotoxicity, and any significant influence on expression of cellular markers associated with BMDC phenotype and maturation status. Read More

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http://dx.doi.org/10.1080/1547691X.2019.1584652DOI Listing
April 2019
2 Reads

Novel cutaneous mediators of chemical allergy.

J Immunotoxicol 2019 Mar 1:1-15. Epub 2019 Mar 1.

a Health Effects Laboratory Division, National Institute of Occupational Safety and Health , Morgantown , WV , USA.

Chemical allergy can manifest into allergic contact dermatitis and asthma and the importance of skin sensitization in both of these diseases is increasingly being recognized. Given the unique characteristics of chemical allergy, coupled with the distinct immunological microenvironment of the skin research is still unraveling the mechanisms through which sensitization and elicitation occur. This review first describes the features of chemical sensitization and the known steps that must occur to develop a chemical allergy. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1515279DOI Listing
March 2019
4 Reads

Transcriptome analysis of low-dose ionizing radiation-impacted genes in CD4 T-cells undergoing activation and regulation of their expression of select cytokines.

J Immunotoxicol 2018 Dec;15(1):137-146

a Low-Dose Radiation Research Team, KHNP Radiation Health Institute, Korea Hydro & Nuclear Power Co., LTD , Seoul , South Korea.

Immune cells are known as the most sensitive tissue for ionizing radiation. Numerous reports relating with the effect of low-dose ionizing radiation (LDIR) on immune activities showed that LDIR can induce immune-potentiation via modulating the activity of B-, T-, and NK cells, or macrophages, whereas high-dose radiation induces genome-wide apoptotic/necrotic tissue injury and immune suppression. Generally, CD4 T-cells play pivotal roles in immune systems via cytokines and cell-surface molecules to activate other types of immune cells to eliminate the pathogen. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1521484DOI Listing
December 2018
1 Read

Obituary.

Authors:
Michael I Luster

J Immunotoxicol 2018 Dec;15(1):30

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http://dx.doi.org/10.1080/1547691X.2017.1419443DOI Listing
December 2018
1 Read

Obituary.

J Immunotoxicol 2018 Dec;15(1):29

a Procter and Gamble Company.

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http://dx.doi.org/10.1080/1547691X.2017.1419429DOI Listing
December 2018

Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury.

J Immunotoxicol 2019 Jan 21:1-6. Epub 2019 Jan 21.

a Department of Pharmaceutical Sciences , Faculty of Pharmacy, University of Toronto , Toronto , Ontario , Canada.

Evidence suggests that macrophages may play a role in the development of idiosyncratic drug-induced liver injury (IDILI). However, there has yet to be a clear link between macrophage activation and the inflammatory infiltrate that is characteristic of IDILI. A major chemokine involved in the recruitment of macrophages into the liver is C-C motif chemokine ligand 2 (CCL2)/monocyte chemoattractant protein 1 (MCP1). Read More

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https://www.tandfonline.com/doi/full/10.1080/1547691X.2018.1
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http://dx.doi.org/10.1080/1547691X.2018.1516014DOI Listing
January 2019
19 Reads

Oligoclonal selection of nanobodies targeting vascular endothelial growth factor.

J Immunotoxicol 2018 Nov 9:1-9. Epub 2018 Nov 9.

a Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory , Pasteur Institute of Iran , Tehran , Iran.

While monoclonal antibodies are efficient therapeutics for cancer treatment, nanobodies or variable heavy domain - due to their small size, high stability, and solubility - have many advantages in comparison. Oligoclonal nanobodies are a mixture of nanobodies against different epitopes of an antigen. Specific nanobodies against vascular endothelial growth factor (VEGF, which has an important role in cancer angiogenesis) were selected from an immune camel library using biopanning. Read More

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https://www.tandfonline.com/doi/full/10.1080/1547691X.2018.1
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http://dx.doi.org/10.1080/1547691X.2018.1526234DOI Listing
November 2018
22 Reads

Bradykinin receptor in immune-mediated renal tubular injury in trichloroethylene-sensitized mice: Impact on NF-κB signaling pathway.

J Immunotoxicol 2018 Dec;15(1):126-136

a Institute of Dermatology , Anhui Medical University , Hefei , Anhui , China.

Trichloroethylene (TCE) is known to induce skin disorders and multi-system dysfunction, but the mechanism of this multi-organ injury is not entirely clear. It was shown in a previous study that levels of pivotal end-products of the kallikrein-kinin system (KKS), i.e. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1532974DOI Listing
December 2018
15 Reads

Assessment of the potential allergenicity of genetically-engineered food crops.

Authors:
Gregory S Ladics

J Immunotoxicol 2018 Nov 9:1-11. Epub 2018 Nov 9.

a DuPont Company , Wilmington , DE , USA.

An extensive safety assessment process exists for genetically-engineered (GE) crops. The assessment includes an evaluation of the introduced protein as well as the crop containing the protein with the goal of demonstrating the GE crop is "as-safe-as" non-GE crops in the food supply. One of the evaluations for GE crops is to assess the expressed protein for allergenic potential. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1533904DOI Listing
November 2018
2 Reads

The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash.

J Immunotoxicol 2018 Oct 14:1-12. Epub 2018 Oct 14.

a Amgen Research , Thousand Oaks , CA , USA.

Current advances in the study of cutaneous adverse drug reactions can be attributed to the recent understanding that the skin is both a metabolically and immunologically competent organ. The ability of the skin to serve as a protective barrier with limited drug biotransformation ability, yet highly active immune function, has provided insights into its biological capability. While the immune response of the skin to drugs is vastly different from that of the liver due to evolutionary conditioning, it frequently occurs in response to various drug classes and manifests as a spectrum of hypersensitivity reactions. Read More

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https://www.tandfonline.com/doi/full/10.1080/1547691X.2018.1
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http://dx.doi.org/10.1080/1547691X.2018.1514444DOI Listing
October 2018
12 Reads

Development of a BiTE-mediated CD8 cytotoxic T-lymphocyte activity assay to assess immunomodulatory potential of drug candidates in Cynomolgus macaque.

J Immunotoxicol 2018 12;15(1):119-125

a Comparative Biology and Safety Sciences , Amgen Inc. , South San Francisco , CA , USA.

The immunotoxic potential of drug candidates is assessed through the examination of results from a variety of studies and endpoints. While the functional assessment of CD8 cytotoxic T-lymphocytes (CTL) is well-characterized in the clinic, the lack of a robust macaque CTL functional assay has been an important hurdle in evaluating and accurately quantifying cell-mediated CD8 T-cell effector responses in the nonclinical setting. This paper describes the development of an assay to measure CTL activity in peripheral blood mononuclear cells (PBMC) isolated from Cynomolgus macaques. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1486342DOI Listing
December 2018
139 Reads
1.910 Impact Factor

Methoxychlor metabolite HPTE alters viability and differentiation of embryonic thymocytes from C57BL/6 mice.

J Immunotoxicol 2018 12;15(1):104-118

b Department of Biology , University of La Verne , La Verne , CA , USA.

Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pesticides, such as methoxychlor (MXC), have adverse effects on immune cells, but no studies have addressed the impact of HPTE, the primary metabolite of MXC. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1474978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120686PMC
December 2018
6 Reads

Modulation of cytokine/chemokine production in human macrophages by bisphenol A: A comparison to analogues and interactions with genistein.

J Immunotoxicol 2018 12;15(1):96-103

a Department of Veterinary Biosciences and Diagnostic Imaging , College of Veterinary Medicine, University of Georgia , Athens , GA , USA.

The immunotoxicant bisphenol A (BPA) may produce toxic effects on organs and systems, in part, by altering the secretion of cytokines and chemokines. However, systematic studies of the effects of BPA, let alone of its analogs and in cases when there are interactions with other chemicals, on innate immunity and cytokine modulation are limited. The objectives of this study were to investigate the immunomodulatory effects of: (1) BPA and its analogs, BPS and BPAF; and (2) the interaction between BPA and genistein (GEN), a partial estrogen agonist or antagonist. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1476629DOI Listing
December 2018
4 Reads

Use of an animal model to test whether non-alcoholic fatty liver disease increases the risk of idiosyncratic drug-induced liver injury.

J Immunotoxicol 2018 12;15(1):90-95

a Department of Pharmaceutical Sciences, Faculty of Pharmacy , University of Toronto , Toronto , Ontario , Canada.

Clinical evidence suggests that most idiosyncratic drug-induced liver injury (IDILI) is immune-mediated. The danger hypothesis suggests that liver injury and inflammation would increase the risk of an immune response leading to IDILI. Therefore, a reasonable hypothesis would be that an underlying chronic liver disease such as non-alcoholic steatohepatitis (NASH) would increase the risk of developing IDILI due to inflammation and release of danger signals from damaged cells. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1467982DOI Listing
December 2018
4 Reads

Predicting skin sensitization potential of organic compounds based on toxicity enhancement to Tetrahymena pyriformis, fathead minnow, and Daphnia magna.

J Immunotoxicol 2018 12;15(1):82-89

a Henan Key Laboratory of Ecological Security and Collaborative Innovation Center of Water Security for Water Source Region of Mid-line of South-to-North Diversion, Project of Henan Province , College of Agricultural Engineering, Nanyang Normal University , Nanyang , China.

Skin sensitization is an important occupational health problem and immunotoxicity endpoint. Considering animal welfare and time and cost savings, many alternative approaches, such as those conducted in vitro, in silico, and in chemo, have been proposed and applied to predict skin sensitization of compounds. Toxicologically, sensitizers can elicit excess toxicity at greater levels than non-sensitizers due to their capacity to react with proteins/peptides. Read More

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https://www.tandfonline.com/doi/full/10.1080/1547691X.2018.1
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http://dx.doi.org/10.1080/1547691X.2018.1465144DOI Listing
December 2018
9 Reads

Sex differences impact the lung-bone inflammatory response to repetitive inhalant lipopolysaccharide exposures in mice.

J Immunotoxicol 2018 12;15(1):73-81

a Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine , University of Nebraska Medical Center , Omaha , NE , USA.

Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but comparison effects in females are unknown. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1460425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122601PMC
December 2018
14 Reads

NF-κB signaling pathway-enhanced complement activation mediates renal injury in trichloroethylene-sensitized mice.

J Immunotoxicol 2018 12;15(1):63-72

c Institute of Dermatology , Anhui Medical University , Hefei , Anhui , China.

Both NF-κB pathway and complement activation appear to be involved in kidney damage induced by trichloroethylene (TCE). However, any relationship between these two systems has not yet been established. The present study aimed to clarify the role of NF-κB in complement activation and renal injury in TCE-sensitized BALB/c mice. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1420712DOI Listing
December 2018
9 Reads

In vitro marker gene expression analyses in human peripheral blood mononuclear cells: A tool to assess safety of influenza vaccines in humans.

J Immunotoxicol 2018 12;15(1):53-62

a Department of Safety Research on Blood and Biological Products , National Institute of Infectious Diseases , Tokyo , Japan.

Vaccines are inoculated in healthy individuals from children to the elderly, and thus high levels of safety and consistency of vaccine quality in each lot must meet the required specifications by using preclinical and lot release testing. Because vaccines are inoculated into humans, recapitulation of biological reactions in humans should be considered for test methods. We have developed a new method to evaluate the safety of influenza vaccines using biomarker gene expression in mouse and rat models. Read More

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http://dx.doi.org/10.1080/1547691X.2018.1447052DOI Listing
December 2018
12 Reads
1.910 Impact Factor

Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague-Dawley rats and BCF/N mice when administered by oral gavage for 28 days.

J Immunotoxicol 2018 12;15(1):41-52

a Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , NC , USA.

Poly- and perfluoroalkyl substances (PFAS) are chemically and thermally stable, hydrophobic, lipophobic compounds used in stain repellants and water and oil surfactants, and associated with immunosuppression and peroxisome proliferator activity. Perfluoro-n-decanoic acid (PFDA, (CF(CF)COOH), a fluorinated straight chain fatty acid compound, is reported to induce thymic atrophy and reversible bone marrow hypocellularity in rodent models. The objective of this study was to assess potential immunotoxicity of PFDA, due to its structural similarity to other immunosuppressive PFASs. Read More

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https://www.tandfonline.com/doi/full/10.1080/1547691X.2018.1
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http://dx.doi.org/10.1080/1547691X.2018.1445145DOI Listing
December 2018
13 Reads

Prevalence of anti-nuclear autoantibodies in subjects exposed to natural asbestiform fibers: a cross-sectional study.

J Immunotoxicol 2018 12;15(1):24-28

a Department of Clinical and Experimental Medicine , University of Catania , Catania , Italy.

Fluoro-edenite (FE) is an asbestiform mineral fiber spotted in the lava rocks excavated from a stone quarry in Biancavilla (Italy). The derived material had been employed locally for building purposes. Previous studies found evidence that exposure to asbestos may induce autoimmunity, with frequency of anti-nuclear autoantibodies (ANA). Read More

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http://dx.doi.org/10.1080/1547691X.2017.1415398DOI Listing
December 2018
18 Reads

Fibrous nanocellulose, crystalline nanocellulose, carbon nanotubes, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice.

J Immunotoxicol 2018 12;15(1):12-23

b Exposure Assessment Branch , NIOSH/CDC , Morgantown , WV , USA.

With the rapid development of synthetic alternatives to mineral fibers, their possible effects on the environment and human health have become recognized as important issues worldwide. This study investigated effects of four fibrous materials, i.e. Read More

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https://www.tandfonline.com/doi/full/10.1080/1547691X.2017.1
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http://dx.doi.org/10.1080/1547691X.2017.1414339DOI Listing
December 2018
27 Reads

Vanadium pentoxide increased PTEN and decreased SHP1 expression in NK-92MI cells, affecting PI3K-AKT-mTOR and Ras-MAPK pathways.

J Immunotoxicol 2018 12;15(1):1-11

a Laboratorio de Inmunobiología, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM , Mexico City , México.

Vanadium is an air pollutant that imparts immunosuppressive effects on NK cell immune responses, in part, by dysregulating interleukin (IL)-2/IL-2R-mediated JAK signaling pathways and inducing apoptosis. The aim of the present study was to evaluate effects of vanadium pentoxide (VO) on other IL-2 receptor-mediated signaling pathways, i.e. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1404662DOI Listing
December 2018
14 Reads

Effect of nicotine on placental ischemia-induced complement activation and hypertension in the rat.

J Immunotoxicol 2017 12;14(1):235-240

a Department of Biomedical Sciences , University of Minnesota, Medical School , Duluth , MN , USA.

Preeclampsia is a pregnancy-specific condition manifested by new-onset maternal hypertension with systemic inflammation, including increased innate immune system complement activation. While exact pathophysiology is unknown, evidence suggests that inadequate spiral artery invasion and resulting utero-placental insufficiency is the initiating event. Cigarette smoking during pregnancy decreases the risk of preeclampsia. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1394934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298215PMC
December 2017
8 Reads

Celastrol attenuates impairments associated with lipopolysaccharide-induced acute respiratory distress syndrome (ARDS) in rats.

Authors:
Yongjun Wei Yu Wang

J Immunotoxicol 2017 12;14(1):228-234

a Tianjin First Center Hospital , Tianjin , China.

Celastrol, a constituent from a traditional Chinese medicinal herb belonging to the family Celastraceae, has been shown to impart anti-inflammatory properties, in part, by inhibiting NF-κB activity and related induction of pro-inflammatory cytokine formation/release. The present study investigated the effects of celastrol in an animal model of acute respiratory distress syndrome (ARDS) induced by intratracheal administration of lipopolysaccharides (LPSs). Celastrol pre-treatment groups received celastrol by intraperitoneal injection on seven consecutive days before LPS treatment. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1394933DOI Listing
December 2017
4 Reads

Assessment of immunotoxicity in female Fischer 344/N and Sprague Dawley rats and female BCF mice exposed to hexavalent chromium via the drinking water.

J Immunotoxicol 2017 12;14(1):215-227

a Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , NC , USA.

Sodium dichromate dihydrate (SDD), an inorganic compound containing hexavalent chromium (Cr(VI)), is a common environmental contaminant of groundwater sources due to widespread industrial use. There are indications in the literature that Cr(VI) may induce immunotoxic effects following dermal exposure, including acting as both an irritant and a sensitizer; however, the potential immunomodulatory effects of Cr(VI) following oral exposure are relatively unknown. Following the detection of Cr(VI) in drinking water sources, the National Toxicology Program (NTP) conducted extensive evaluations of the toxicity and carcinogenicity of SDD following drinking water exposure, including studies to assess the potential for Cr(VI) to modulate immune function. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1394932DOI Listing
December 2017
5 Reads

Divergent hypersensitivity responses following topical application of the quaternary ammonium compound, didecyldimethylammonium bromide.

J Immunotoxicol 2017 12;14(1):204-214

a Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , WV , USA.

Didecyldimethylammonium bromide (DDAB) is a fourth generation dialkyl-quaternary ammonium compound (QAC) that is used in numerous products for its antimicrobial properties. While many QACs have been associated with allergic disease, the toxicity and sensitization of DDAB have not been thoroughly investigated. The purpose of these studies was to evaluate the irritancy and sensitization potential of DDAB following dermal application in a murine model. Read More

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https://www.tandfonline.com/doi/full/10.1080/1547691X.2017.1
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http://dx.doi.org/10.1080/1547691X.2017.1397826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391722PMC
December 2017
27 Reads

Expression of aryl hydrocarbon receptor, inflammatory cytokines, and incidence of rheumatoid arthritis in Vietnamese dioxin-exposed people.

J Immunotoxicol 2017 12;14(1):196-203

a National Key Laboratory of Gene Technology , Institute of Biotechnology, Vietnam Academy of Science and Technology , Hanoi , Vietnam.

Many Vietnamese citizens have been and continue to be inadvertently exposed to dioxins and dioxin-like compounds deposited in the country during the Vietnam War. Dioxins may be involved in the pathogenesis of inflammatory diseases in part via by affecting expression of aryl hydrocarbon receptor (Ahr) and inflammatory cytokines in animal models. As the role of the Ahr in dioxin-exposed people is not well defined, a study was conducted to examine gene expression levels of Ahr, inflammatory cytokines, and the incidence of diseases in dioxin-exposed citizens who had/still resided near a heavily dioxin-contaminated area in Vietnam. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1377323DOI Listing
December 2017
23 Reads

Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody concentrations at age 5-years.

J Immunotoxicol 2017 12;14(1):188-195

e Department of Biostatistics , University of Copenhagen , Copenhagen , Denmark.

Perfluorinated alkylate substances (PFASs) are highly persistent and may cause immunotoxic effects. PFAS-associated attenuated antibody responses to childhood vaccines may be affected by PFAS exposures during infancy, where breastfeeding adds to PFAS exposures. Of 490 members of a Faroese birth cohort, 275 and 349 participated in clinical examinations and provided blood samples at ages 18 months and 5 years. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1360968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190594PMC
December 2017
33 Reads

Long form of thymic stromal lymphopoietin of keratinocytes is induced by protein allergens.

J Immunotoxicol 2017 12;14(1):178-187

b Department of Materials Science and Engineering, Faculty of Engineering , Yokohama National University , Yokohama , Japan.

A growing body of evidence suggests that epicutaneous sensitization of protein allergens induces immediate-type hypersensitivity (IHS) following induction of Type 2 immune responses in animals and humans. Thymic stromal lymphopoietin (TSLP) derived from keratinocytes is a cytokine that can activate dendritic cells and has been implicated in development of inflammatory Type 2 helper T-cells. However, there is no direct evidence that allergens directly regulate TSLP expression in keratinocytes. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1349220DOI Listing
December 2017
29 Reads

Bisphenol A (BPA) aggravates multiple low-dose streptozotocin-induced Type 1 diabetes in C57BL/6 mice.

J Immunotoxicol 2017 12;14(1):160-168

a Department of Biological Sciences , St. Cloud State University , St. Cloud , MN , USA.

Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disorder characterized by destruction of insulin-producing pancreatic β-cells. Whereas epidemiological data implicate environmental factors in the increasing incidence of T1D, their identity remains unknown. Though exposure to bisphenol A (BPA) has been associated with several disorders, no epidemiologic evidence has linked BPA exposure and T1D. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1334722DOI Listing
December 2017
5 Reads

Transferon™, a peptide mixture with immunomodulatory properties is not immunogenic when administered with various adjuvants.

J Immunotoxicol 2017 12;14(1):169-177

a Unidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Instituto Politécnico Nacional , Mexico City , Mexico.

Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that block or diminish their therapeutic effect. Nevertheless, few studies have evaluated peptide-derived drug immunogenicity. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1346009DOI Listing
December 2017
21 Reads

Correction to: Islam et al., Evaluation of immunomodulatory effects of zearalenone in mice.

Authors:

J Immunotoxicol 2017 12 12;14(1):241. Epub 2017 Jul 12.

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http://dx.doi.org/10.1080/1547691X.2017.1353242DOI Listing
December 2017
4 Reads

Safety of a proteoliposome from Neisseria meningitides as adjuvant for a house dust mite allergy vaccine.

J Immunotoxicol 2017 12;14(1):152-159

a Allergens Department , Centro Nacional de Biopreparados , Bejucal , Mayabeque , Cuba.

The proteoliposome (PL) of Neisseria meningitidis serogroup B has been reported as a safe and potent vaccine adjuvant, inducing a T1-skewed response. The present study describes a pre-clinical safety evaluation of an allergy therapeutic vaccine candidate based on purified allergens from Dermatophagoides siboney house dust mite and PL as adjuvant, both components adsorbed onto aluminum hydroxide gel. Two separate studies of acute toxicity evaluation were performed in mice and rabbits, and two repeat-dose studies were conducted in non-sensitized and allergen-sensitized Balb/c mice, respectively. Read More

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https://www.tandfonline.com/doi/full/10.1080/1547691X.2017.1
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http://dx.doi.org/10.1080/1547691X.2017.1346007DOI Listing
December 2017
21 Reads

Genetics and immunodysfunction underlying Behçet's disease and immunomodulant treatment approaches.

J Immunotoxicol 2017 12;14(1):137-151

h Department of Medical Genetics , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Behçet's disease (BD) is a chronic autoimmune condition primarily prevalent in populations along the Mediterranean Sea. The exact etiology of BD has not been fully explained yet, but the disease occurrence is associated with a genetic factor, human leukocyte antigen (HLA)-B51 antigen. Among the various immunodysfunctions that are found in BD, patients are increased neutrophil motility and superoxide production, as well as elevated production of tumor necrosis factor (TNF)-α and decreased production of interleukin (IL)-10. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1346008DOI Listing
December 2017
27 Reads

Evaluation of immunomodulatory effects of zearalenone in mice.

J Immunotoxicol 2017 12;14(1):125-136

a Biosafety Research Institute and College of Veterinary Medicine (BK21 Plus Program) , Chonbuk National University , Iksan , Republic of Korea.

Zearalenone (ZEA) is a non-steroidal estrogenic mycotoxin produced by Fusarium species. The toxicity of ZEA has been evaluated for reproductive and developmental effects; however, there is little evidence about its acute toxicity or general immunotoxicity. In the present study, immune regulatory functions were investigated in mice that had been exposed to ZEA (5 or 20 mg/kg BW) daily for 14 days. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1340371DOI Listing
December 2017
24 Reads

Impact of exposure time, particle size and uptake pathway on silver nanoparticle effects on circulating immune cells in mytilus galloprovincialis.

J Immunotoxicol 2017 12;14(1):116-124

a Research Unit for Immuno-Microbiology Environmental and Cancerogenesis, Sciences Faculty of Bizerte , University of Carthage , Bizerte , Tunisia.

Nanomaterials have increasingly emerged as potential pollutants to aquatic organisms. Nanomaterials are known to be taken up by hemocytes of marine invertebrates including Mytilus galloprovincialis. Indeed, assessments of hemocyte-related parameters are a valuable tool in the determination of potentials for nanoparticle (NP) toxicity. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1335810DOI Listing
December 2017
12 Reads

Human in situ cytokine and leukocyte responses to acute smoking.

J Immunotoxicol 2017 12;14(1):109-115

a School of Exercise Science, Sport & Health , Charles Sturt University , Bathurst , Australia.

This study examined immune/inflammatory parameters following an acute tobacco smoking episode in smokers with varying smoking histories. Twenty-eight male habitual smokers were categorized according to smoking history, e.g. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1332699DOI Listing
December 2017
12 Reads

Anti-drug antibodies in Colombian patients with rheumatoid arthritis treated with Enbrel vs Etanar - Preliminary report.

J Immunotoxicol 2017 12;14(1):103-108

a Pharmacy Department, Immunotoxicology Research Group , National University of Colombia, and Foundation Institute of Immunology of Colombia , Bogota , Colombia.

The present study was undertaken to detect antibodies against etanercept (ETN) in a group of Colombian patients with rheumatoid arthritis (RA) and being treated with Enbrel vs. Etanar. From these patients with RA, clinical and laboratory data were collected and serum taken for anti-drug antibody (ADAb) analysis. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1317885DOI Listing
December 2017
5 Reads

A single dose of trichloroethylene given during development does not substantially alter markers of neuroinflammation in brains of adult mice.

J Immunotoxicol 2017 12;14(1):95-102

a Department of Pharmacology and Toxicology , Brody School of Medicine, East Carolina University Greenville , NC , USA.

Trichloroethylene (TCE) is a widespread environmental contaminant associated with developmental immunotoxicity and neurotoxicity. Previous studies have shown that MRL mice exposed to TCE from gestation through early-life demonstrate robust increases in inflammatory markers in peripheral CD4 T-cells, as well as glutathione depletion and increased oxidative stress in cerebellum-associated with alterations in behavior. Since increased oxidative stress is associated with neuroinflammation, we hypothesized that neuroinflammatory markers could be altered relative to unexposed mice. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1305021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540234PMC
December 2017
8 Reads

Effects of immunization and checkpoint inhibition on amodiaquine-induced liver injury.

J Immunotoxicol 2017 12;14(1):89-94

a Department of Pharmaceutical Sciences, Faculty of Pharmacy , University of Toronto , Toronto , Ontario , Canada.

If idiosyncratic drug-induced liver injury (IDILI) is immune-mediated, it is possible that an individual's prior exposure to antigens may affect their susceptibility to IDILI. An individual's repertoire of memory immune cells is shaped by every past exposure to antigens. Subsequent drug-induced adverse drug reactions may therefore involve an immune cell's cross reactivity between a prior antigen and resulting drug-modified proteins. Read More

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http://dx.doi.org/10.1080/1547691X.2017.1290716DOI Listing
December 2017
5 Reads

Topical application of the anti-microbial chemical triclosan induces immunomodulatory responses through the S100A8/A9-TLR4 pathway.

J Immunotoxicol 2017 12;14(1):50-59

a Allergy and Clinical Immunology Branch , National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Morgantown , WV , USA.

The anti-microbial compound triclosan is incorporated into numerous consumer products and is detectable in the urine of 75% of the general United States population. Recent epidemiological studies report positive associations with urinary triclosan levels and allergic disease. Although not sensitizing, earlier studies previously found that repeated topical application of triclosan augments the allergic response to ovalbumin (OVA) though a thymic stromal lymphopoietin (TSLP) pathway in mice. Read More

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http://dx.doi.org/10.1080/1547691X.2016.1258094DOI Listing
December 2017
27 Reads

Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response.

J Immunotoxicol 2017 12;14(1):31-38

g Department of Internal Medicine , Wake Forest University School of Medicine , Winston-Salem , NC , USA.

Drug-induced liver injury (DILI) is a growing problem. Diagnostic methods to differentiate DILI caused by an adaptive immune response from liver injury of other causes or to identify the responsible drug in patients receiving multiple drugs, herbals and/or dietary supplements (polypharmacy) have not yet been established. The lymphocyte transformation test (LTT) has been proposed as a diagnostic method to determine if a subject with an apparent hypersensitivity reaction has become sensitized to a specific drug. Read More

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http://dx.doi.org/10.1080/1547691X.2016.1254305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505862PMC
December 2017
75 Reads

Effects of arsenic on porcine dendritic cells in vitro.

J Immunotoxicol 2017 12 17;14(1):1-8. Epub 2017 Jan 17.

b Department of Geology, Faculty of Basic Sciences , Ferdowsi University of Mashhad , Mashhad , Iran.

Exposure to arsenic (As) is an ongoing, and in some places increasing, health problem. Still, however, the effects of As exposure on the immune system are not well understood. Dendritic cells (DC) are a critical immune cell that bridges the innate and adaptive immune systems. Read More

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http://dx.doi.org/10.1080/1547691X.2016.1249985DOI Listing
December 2017
5 Reads

Early immunopathological events in acute model of mycobacterial hypersensitivity pneumonitis in mice.

J Immunotoxicol 2017 12 17;14(1):77-88. Epub 2017 Jan 17.

a Department of Environmental Health, Microbial Pathogenesis and Immunotoxicology Laboratory, Division of Environmental Genetics and Molecular Toxicology , University of Cincinnati College of Medicine , Cincinnati , OH , USA.

Prolonged exposure to antigens of non-tuberculous mycobacteria species colonizing industrial metalworking fluid (MWF), particularly Mycobacterium immunogenum (MI), has been implicated in chronic forms of hypersensitivity pneumonitis (HP) in machinists based on epidemiology studies and long-term exposure of mouse models. However, a role of short-term acute exposure to these antigens has not been described in the context of acute forms of HP. This study investigated short-term acute exposure of mice to MI cell lysate (or live cell suspension) via oropharyngeal aspiration. Read More

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http://dx.doi.org/10.1080/1547691X.2016.1273284DOI Listing
December 2017
6 Reads

Protective role of bentonite against aflatoxin B- and ochratoxin A-induced immunotoxicity in broilers.

J Immunotoxicol 2017 12 17;14(1):66-76. Epub 2017 Jan 17.

d Department of Animal Health, Faculty of Animal Husbandry and Veterinary Sciences , University of Agriculture Peshawar , Pakistan.

The present study was designed to investigate any ameliorative effects of bentonite (BN) against immuno-pathological alterations induced by dietary aflatoxin B (AFB) or ochratoxin A (OTA) in broiler chicks. In one experiment, AFB (0.1, 0. Read More

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http://dx.doi.org/10.1080/1547691X.2016.1264503DOI Listing
December 2017
10 Reads

Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination.

J Immunotoxicol 2017 12 16;14(1):39-49. Epub 2017 Jan 16.

a Department of Environmental Medicine , University of Southern Denmark , Odense , Denmark.

Perfluoroalkyl substances (PFASs) are highly persistent chemicals that might be associated with asthma and allergy, but the associations remain unclear. Therefore, this study examined whether pre- and postnatal PFAS exposure was associated with childhood asthma and allergy. Measles, mumps, and rubella (MMR) vaccination in early life may have a protective effect against asthma and allergy, and MMR vaccination is therefore taken into account when evaluating these associations. Read More

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http://dx.doi.org/10.1080/1547691X.2016.1254306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190697PMC
December 2017
17 Reads

Effects of fostriecin on β2-adrenoceptor-driven responses in human mast cells.

J Immunotoxicol 2017 12 16;14(1):60-65. Epub 2017 Jan 16.

c Academic Unit of Respiratory Medicine , Medical School, University of Sheffield , Sheffield , UK.

As part of the intracellular processes leading to mast cell and basophil activation, phosphorylation of key substrates is likely to be important. These processes, mediated by phosphatases, are responsible for regulating phosphorylation. The aim of the present study was to determine effects fostriecin - a selective inhibitor of PP2A (protein phosphatase-2) - on β-adrenoceptor-driven responses in human mast cells. Read More

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http://dx.doi.org/10.1080/1547691X.2016.1259277DOI Listing
December 2017
5 Reads

Impact of C-rel inhibition of cord blood-derived B-, T-, and NK cells.

J Immunotoxicol 2017 12 16;14(1):15-22. Epub 2017 Jan 16.

a Stem Cell Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.

The c-Rel transcription factor is a unique member of the nuclear factor (NF)-κB family that has a role in curtailing the proliferation, differentiation, cytokine production, and overall activity of B- and T-cells. In addition, c-Rel is a key regulator of apoptosis in that it influences the expression of anti-apoptotic genes such as Bcl-2 and Bcl-xL; conversely, inhibition of c-Rel increases cell apoptosis. To better understand the relationship between c-Rel expression and effects on B- and T-cell expansion, the current study evaluated c-Rel expression in cord blood mononuclear cells. Read More

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http://dx.doi.org/10.1080/1547691X.2016.1250849DOI Listing
December 2017
9 Reads
1.907 Impact Factor

Isolation and characterization of anti c-met single chain fragment variable (scFv) antibodies.

J Immunotoxicol 2017 12 16;14(1):23-30. Epub 2017 Jan 16.

g Liver and Gastrointestinal Diseases Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

The receptor tyrosine kinase (RTK) Met is the cell surface receptor for hepatocyte growth factor (HGF) involved in invasive growth programs during embryogenesis and tumorgenesis. There is compelling evidence suggesting important roles for c-Met in colorectal cancer proliferation, migration, invasion, angiogenesis, and survival. Hence, a molecular inhibitor of an extracellular domain of c-Met receptor that blocks c-Met-cell surface interactions could be of great thera-peutic importance. Read More

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http://dx.doi.org/10.1080/1547691X.2016.1251512DOI Listing
December 2017
15 Reads