7 results match your criteria Journal of Immunology[Journal]

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Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2DCD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus.

Open J Immunol 2017 Mar 29;7(1):1-17. Epub 2017 Mar 29.

Clinical Research Division, Fred Hutch, Seattle, WA, USA.

Abnormal NKG2D ligand expression has been implicated in the initiation and maintenance of various auto-inflammatory disorders including systemic lupus erythematosus (SLE). This study's goal was to identify the cellular contexts providing NKG2D ligands for stimulation of the immunosuppressive NKG2DCD4 T cell subset that has been implicated in modulating juvenile-onset SLE disease activity. Although previous observations with NKG2DCD4 T cells in healthy individuals pointed towards peripheral B cell and myeloid cell compartments as possible sites of enhanced NKG2DL presence, we found no evidence for a disease-associated increase of NKG2DL-positivity among juvenile-onset SLE B cells and monocytes. Read More

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http://dx.doi.org/10.4236/oji.2017.71001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604888PMC
March 2017
10 Reads

B Cells with Regulatory Function in Animal Models of Autoimmune and Non-Autoimmune Diseases.

Open J Immunol 2015 Mar;5(1):9-17

Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, USA.

Although the identification of B cell subsets with negative regulatory functions and the definition of their mechanisms of action are recent events, the important negative regulatory roles of B cells in immune responses are now broadly recognized. There is an emerging appreciation for the pivotal role played by B cells in several areas of human diseases including autoimmune diseases and non-autoimmune diseases such as parasite infections and cancer. The recent research advancement of regulatory B cells in human disease coincides with the vastly accelerated pace of research on the bridging of innate and adaptive immune system. Read More

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http://dx.doi.org/10.4236/oji.2015.51002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517676PMC
March 2015
9 Reads

Lipopolysaccharide Attenuates CD40 Ligand-Induced Regulatory B10 Cell Expansion and IL-10 Production in Mouse Splenocytes.

Open J Immunol 2015 Mar;5(1):1-8

Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, USA.

Toll-like receptors (TLRs) play a key role in B cell-mediated innate and adaptive immunity. It has been shown that interleukin 10 (IL-10)-producing regulatory B cells (B10 cells) can negatively regulate cellular immune responses and inflammation in autoimmune diseases. In this study, we determined the effect of TLR4 signaling on the CD40-activated B10 cell competency. Read More

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http://dx.doi.org/10.4236/oji.2015.51001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517687PMC
March 2015
14 Reads

Region Specific Effects of Maternal Immune Activation on Offspring Neuroimmune Function.

Authors:
Heping Zhou

Open J Immunol 2015 Jun;5(2):51-63

Department of Biological Sciences, Seton Hall University, New Jersey, USA.

Growing evidence suggests that maternal immune activation has a significant impact on the immuno-competence of the offspring. The present study aimed to characterize region-specific effects of maternal immune activation on the offspring's neuroimmune function. The offspring born to dams treated with saline or lipopolysaccharide (LPS) at gestational day 18 was stimulated with saline or LPS at postnatal day 21, and the mRNA expression of various inflammatory genes in different brain regions of the offspring was analyzed. Read More

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http://dx.doi.org/10.4236/oji.2015.52006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517690PMC
June 2015
9 Reads

Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects.

Open J Immunol 2013 Sep;3(3)

Departments of Oral Biology and Preventive and Community Dentistry, and Department of Pathology and Laboratory Medicine, Schools of Dentistry and Medicine, Indiana University, Indianapolis, USA.

Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential influence of immune responses to I/II. Read More

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http://dx.doi.org/10.4236/oji.2013.33012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875298PMC
September 2013
14 Reads

Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections.

Open J Immunol 2012 Mar 30;2(1):25-39. Epub 2011 Dec 30.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, USA.

We have reported a new innate-like CD4 T cell population that expresses cell surface makers of effector/memory cells and produce Th1 and Th2 cytokines immediately upon activation. Unlike conventional CD4 T cells that are selected by thymic epithelial cells, these CD4 T cells, named T-CD4 T cells, are selected by MHC class II expressing thymocytes. Previously, we showed that the presence of T-CD4 T cells protected mice from airway inflammation suggesting an immune regulatory role of T-CD4 T cells. Read More

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http://dx.doi.org/10.4236/oji.2012.21004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525959PMC
March 2012
14 Reads

Successful expression and purification of DPPD using a codon optimized synthetic gene.

Open J Immunol 2011 Jun 30;1(1):1-7. Epub 2011 Jun 30.

The Forsyth Institute, Global Infectious Disease Research Center, Boston, USA.

DPPD (Rv0061) is a difficult to express protein of Mycobacterium tuberculosis that elicits strong and specific delayed type hypersensitivity reactions in humans infected with M. tuberculosis. Therefore e DPPD is a molecule that can improve the specificity of the tuberculin skin test, which is widely used as an aid for the diagnosis of tuberculosis. Read More

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http://dx.doi.org/10.4236/oji.2011.11001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527103PMC
June 2011
10 Reads
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