24,099 results match your criteria Journal of Hospice & Palliative Nursing [Journal]


Location of Death and End-of-Life Characteristics of Young Adults with Cancer Treated at a Pediatric Hospital.

J Adolesc Young Adult Oncol 2019 Apr 23. Epub 2019 Apr 23.

3 Division of Anesthesia, Department of Palliative Care, Cincinnati Children's Hospital, Cincinnati, Ohio.

Location of death (LOD) is an important aspect of end-of-life (EOL) care. Adolescents and young adults (YAs) with pediatric malignancies are increasingly treated in pediatric institutions. YAs, generally defined as 18-39 years old, deserve specific attention because adults have unique developmental and social considerations compared with younger patients. Read More

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http://dx.doi.org/10.1089/jayao.2018.0123DOI Listing

End-of-Life Costs and Hospice Utilization in Patients with Head and Neck Cancer.

Otolaryngol Head Neck Surg 2019 Apr 23:194599819846072. Epub 2019 Apr 23.

1 Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, USA.

The Quality Oncology Practice Initiative has several metrics related to end-of life (EOL) care, including hospice enrollment ≤3 days, with lower scores signaling better performance. Of privately insured patients with head and neck cancer, 3.5% were enrolled in hospice prior to death and 21. Read More

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http://dx.doi.org/10.1177/0194599819846072DOI Listing

Development of student competencies for palliative care.

Int J Palliat Nurs 2019 Apr;25(4):177-184

Assistant Professor, Faculty of Nursing, Universidad Nacional de Colombia, Bogotá Colombia.

Aim: Identify the palliative care learning needs of healthcare students and determine the acceptability of an innovative learning strategy for palliative care named competencia para cuidar en el hogar-paliar (CUIDAR-PALIAR) aimed to increase students' competencies.

Methods: A single-group mixed methods design was used. A questionnaire was designed and semi-structured interviews were used to determine the palliative care competencies of undergraduate students; 90 students participated in the strategy. Read More

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http://dx.doi.org/10.12968/ijpn.2019.25.4.177DOI Listing

A qualitative descriptive analysis of nurses' perceptions of hospice care for deceased children following organ donation in hospice cool rooms.

Int J Palliat Nurs 2019 Apr;25(4):166-175

Practice Educator, Martin House Children's Hospice, Wetherby, UK.

Background: Following organ donation, bodies of children are generally cared for in hospital mortuaries or by funeral directors, and their families are offered little routine bereavement support. A partnership between an organ donation nursing team and regional children's hospice trialled an initiative where families were offered bereavement support from the hospice, and their child's body was cared for in a 'cool room' after death. Hospice services are usually restricted to children with life-limiting conditions, and their families. Read More

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http://dx.doi.org/10.12968/ijpn.2019.25.4.166DOI Listing
April 2019
1 Read

Production and stability study of a hospital parenteral nutrition solution for neonates.

J Pharm Anal 2019 Apr 11;9(2):83-90. Epub 2018 Jan 11.

Service Pharmaceutique, Site Hôtel-Dieu, Centre Hospitalo-Universitaire de Nantes, 1, place Alexis Ricordeau, F-44093 Nantes Cedex 01, France.

Standard parenteral nutrition solutions are mixtures comprising interacting components that may degrade themselves over time. The objective of this study was to investigate the physicochemical and microbiological stability of a hospital preparation for parenteral nutrition in neonatology. The analyses were performed throughout the storage of the preparations at 2-8 °C (up to 4 months). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20951779183000
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http://dx.doi.org/10.1016/j.jpha.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460230PMC

Deciphering the complexity of the 4q and 10q subtelomeres by molecular combing in healthy individuals and patients with facioscapulohumeral dystrophy.

J Med Genet 2019 Apr 22. Epub 2019 Apr 22.

Aix Marseille Univ, INSERM, MMG, Marseille Medical Genetics U1251, Marseille, France

Background: Subtelomeres are variable regions between telomeres and chromosomal-specific regions. One of the most studied pathologies linked to subtelomeric imbalance is facioscapulohumeral dystrophy (FSHD). In most cases, this disease involves shortening of an array of D4Z4 macrosatellite elements at the 4q35 locus. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105949DOI Listing

Radiographic and Clinical Comparison of Proximal Interphalangeal Joint Arthrodesis Between a Static and Dynamic Implant.

J Foot Ankle Surg 2019 Apr 19. Epub 2019 Apr 19.

Orthopedic Surgeon, IFSTTAR, Laboratoire de Biomécanique et Mécanique des Chocs, Université Lyon 1, Bron Cedex, France; Orthopedic Surgeon, Service de Chirurgie Orthopédique et Traumatologique, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite Cedex, France.

Hammertoe deformation is a frequent motive for consultation in forefoot surgery, and proximal interphalangeal joint arthrodesis is a classic treatment for fixed deformation, which tends to be achieved more and more thanks to specific implants. This work evaluated and compared clinical improvement, radiologic fusion, and complication rates between dynamic (Difuse®) and static (TinyFix®) implants from Biotech Ortho. A total of 95 patients (110 feet and 166 toes; 97 static and 69 dynamic implants) were included. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.11.004DOI Listing

Vascular Access Choice, Complications, and Outcomes in Children on Maintenance Hemodialysis: Findings From the International Pediatric Hemodialysis Network (IPHN) Registry.

Am J Kidney Dis 2019 Apr 19. Epub 2019 Apr 19.

Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany. Electronic address:

Rationale & Objective: Arteriovenous fistulas (AVFs) have been recommended as the preferred vascular access for pediatric patients on maintenance hemodialysis (HD), but data comparing AVFs with other access types are scant. We studied vascular access choice, placement, complications, and outcomes in children.

Study Design: Prospective observational cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.02.014DOI Listing

Caregivers Like Me: An Education Intervention for Family Caregivers of Latino Elders at End-of-Life.

MedEdPORTAL 2016 Sep 1;12:10448. Epub 2016 Sep 1.

Associate Professor of Medicine, Department of Geriatrics, University of Texas School of Medicine at San Antonio.

Introduction: End-of-life (EOL) care delivery to Latinos is a well-documented challenge. The majority of caregivers for Latino patients are family relatives, but because Latino caregivers may spend more hours in the caregiving role than other ethnic groups and are less likely to use additional available health care, caregivers can experience an increased burden. This can result in Latino elders being more vulnerable to receiving aggressive care. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464451PMC
September 2016

"A True Human Interaction": Comparison of Family Caregiver and Hospice Nurse Perspectives On Needs of Family Hospice Caregivers.

J Hosp Palliat Nurs 2014 Jul;16(5):282-290

University of Utah College of Nursing.

Context: Home hospice providers are concerned with family caregiver perceptions about the quality of care and support offered. More research is needed to understand experiences of family caregivers and what "support" means to these family members.

Objective: We compared perceptions of caregiver needs from the family caregiver and the nurse case manager. Read More

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http://dx.doi.org/10.1097/NJH.0000000000000066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469496PMC

Validation of a simple screening test for elementary visuo-spatial perception deficit.

Ann Phys Rehabil Med 2019 Apr 19. Epub 2019 Apr 19.

Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de Rééducation Pédiatrique, Bron, France.

Objective: The reliability and validity of a screening test for a deficit in elementary visuo-spatial perception (EVSP) were evaluated.

Method: This prospective study collected performance from 210 typically-developing individuals and evaluated the internal consistency of the EVSP screening test. Test-retest reliability was examined with 25 individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18770657193005
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http://dx.doi.org/10.1016/j.rehab.2019.03.006DOI Listing
April 2019
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Modified GoPro Hero 6 and 7 for Intraoperative Surgical Recording-Transformation Into a Surgeon-Perspective Professional Quality Recording System.

J Oral Maxillofac Surg 2019 Mar 27. Epub 2019 Mar 27.

Chief, Division of Head and Neck Surgery; Program Director, Head and Neck Oncologic Surgery and Microvascular Fellowship; Associate Department Chair and Professor, Department of Oral and Maxillofacial Surgery, University of Florida College of Medicine-Jacksonville, Jacksonville, FL.

Recent innovations in wearable action cameras with high-definition video recording enable surgeons to use cameras for their surgical procedures. In this study, the GoPro HERO 6 (and 7) Black edition camera was modified step by step to allow for a completely wireless surgeon-perspective recording with a battery life and memory capacity never previously obtained with such a high level of digital video quality. With this system, a surgeon can record for more than 14 hours 26 minutes in 1,080 pixels at 60 frames per second without breaking scrub and capture the operating surgeon's direct view of the field. Read More

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http://dx.doi.org/10.1016/j.joms.2019.03.026DOI Listing

Federal Bill Would Limit Opioid Scrips for Acute Pain.

Authors:
Joey Berlin

Tex Med 2018 Jun 1;114(6):42-44. Epub 2018 Jun 1.

The proposed three-day limit on opioid prescriptions for acute pain would be one of the more impactful provisions for pain doctors and their patients. Exceptions would include prescriptions for chronic pain, cancer care, hospice or end-of-life care, and pain treatment that's part of palliative care. Read More

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Acute Stroke With Large Ischemic Core Treated by Thrombectomy.

Stroke 2019 May;50(5):1164-1171

Department of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France (B.L.).

Background and Purpose- Acute stroke patients with a large ischemic core may still benefit from mechanical thrombectomy (MT), but the predictors of clinical outcome are not well known after MT. We investigated the clinical and imaging factors associated with good outcome and mortality at 90 days in acute stroke patients with a large baseline ischemic core treated with MT. Methods- Data from the multicentric prospective ETIS (Endovascular Treatment in Ischemic Stroke) registry of consecutive acute ischemic stroke patients treated with MT from January 1, 2012, to August 31, 2016, were retrospectively analyzed. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024295DOI Listing

Knowledge and attitudes regarding hospice care among outpatients and family members in two hospitals in China.

Medicine (Baltimore) 2019 Apr;98(16):e15230

Research Center of Clinical Epidemiology.

Access to hospice care is widely provided in Western countries, but the supply of such service is still in its initiative stage in China. As relatives are often involved in end-of-life decision making in China, a better understanding of their cognitions toward hospice care would help policy makers and physicians to overcome the barriers of providing such service. Thus, we conducted the study to assess the level of knowledge and attitudes among Chinese outpatients and family members regarding hospice care. Read More

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http://dx.doi.org/10.1097/MD.0000000000015230DOI Listing

Influence of Peer Physicians on Intensity of End-of-Life Care for Cancer Decedents.

Med Care 2019 Apr 18. Epub 2019 Apr 18.

Department of Health Care Policy, Harvard Medical School.

Background: The intensity of end-of-life care varies substantially both within and between areas. Differing practice patterns of individual physicians are likely influenced by their peers.

Objective: To assess whether intensity of end-of-life care previously provided by a physician's peers influences patterns of care at the end-of-life for that physician's patients. Read More

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http://Insights.ovid.com/crossref?an=00005650-900000000-9846
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http://dx.doi.org/10.1097/MLR.0000000000001124DOI Listing
April 2019
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Opioid-prescribing Outcomes of Medicare Beneficiaries Managed by Nurse Practitioners and Physicians.

Med Care 2019 Apr 18. Epub 2019 Apr 18.

The Heller School, Brandeis University, Waltham, MA.

Background: Primary care providers are at the center of the opioid epidemic. Whether nurse practitioners (NPs) have different opioid-prescribing outcomes from physicians is not known.

Objective: To examine opioid-prescribing outcomes of Medicare beneficiaries receiving care from NPs and physicians in primary care. Read More

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http://dx.doi.org/10.1097/MLR.0000000000001126DOI Listing

Understanding Underuse of Advance Care Planning Among a Cohort of African American Patients With Advanced Cancer: Formative Research That Examines Gaps in Intent to Discuss Options for Care.

Am J Hosp Palliat Care 2019 Apr 21:1049909119843276. Epub 2019 Apr 21.

2 Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.

Background: Advance care planning (ACP), palliative care (PC), and hospice are often underutilized by African Americans (AAs). This study assessed the impact of stage of intent to discuss ACP options as key potential barriers.

Methods: We examined intent to discuss completion of ACP, PC, and hospice among 22 AA patients with cancer admitted to a local safety net hospital. Read More

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http://dx.doi.org/10.1177/1049909119843276DOI Listing

Clomiphene citrate and neural tube defects: a meta-analysis of controlled observational studies.

BJOG 2019 Apr 21. Epub 2019 Apr 21.

Service Hospitalo-Universitaire de Pharmaco-Toxicologie, Hospices Civils de Lyon, France.

Background: At the end of the 80's several studies have suggested a potential increased risk of neural tube defects (NTDs) with ovulation induction/fertility drugs, especially with clomiphene citrate (CC). A previous meta-analysis of observational studies evaluating the risk of NTDs associated with the use of CC performed in 1995 found a risk ratio of 1.08 (95% confidence intervals (CI) 0. Read More

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http://dx.doi.org/10.1111/1471-0528.15800DOI Listing

Deep continuous patient-requested sedation until death: a multicentric study.

BMJ Support Palliat Care 2019 Apr 20. Epub 2019 Apr 20.

Department of Palliative Care, Hospices Civils de Lyon, Lyon, France

Objectives: In 2016, a new law was adopted in France granting patients the right, under specific conditions, to continuous deep sedation until death (CDSUD). The goal of this study was to measure the frequency of requests for CDSUD from patients in palliative care.

Methods: The data collected from the medical records of patients in palliative care units (PCU) or followed by palliative care support teams (PCST) in the Rhône-Alpes area, who died after CDSUD, focused on the patient's characteristics, the drugs used (and compliance with regulatory processes). Read More

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http://spcare.bmj.com/lookup/doi/10.1136/bmjspcare-2018-0017
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http://dx.doi.org/10.1136/bmjspcare-2018-001712DOI Listing
April 2019
1 Read

Hangman's fracture: Management strategy and healing rate in a prospective multi-centre observational study of 34 patients.

Orthop Traumatol Surg Res 2019 Apr 17. Epub 2019 Apr 17.

Société Française de Chirurgie Rachidienne, 56, rue Boisonnade, 75014 Paris, France.

Background: Hangman's fractures account for 15% to 20% of all cervical spine fractures. The grading system developed by Effendi and modified by Levine and Edwards is generally used as the basis for management decisions. Nonetheless, the optimal management remains controversial. Read More

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http://dx.doi.org/10.1016/j.otsr.2019.03.009DOI Listing

Recurrence Rate and Cost Consequence of the Shortage of Bacillus Calmette-Guérin Connaught Strain for Bladder Cancer Patients.

Eur Urol Focus 2019 Apr 17. Epub 2019 Apr 17.

Service d'Urologie et Chirurgie de la Transplantation, Hôpital Edouard Herriot, Université Lyon Claude Bernard, Lyon, France; Hôpital Edouard Herriot, Hospices Civils de Lyon et Université Claude Bernard, Lyon, France. Electronic address:

Background: Between 2013 and 2016, global production of bacillus Calmette-Guérin (BCG) was dramatically reduced due to the collapse of the factory producing BCG Connaught.

Objective: To evaluate the clinical and economic impact of BCG shortage on a cohort of non-muscle-invasive bladder cancer (NMIBC) patients treated during the period of restricted supply.

Design, Setting And Participants: This retrospective, before and after, cost-consequence study included patients with intermediate- and high-risk NMIBC. Read More

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http://dx.doi.org/10.1016/j.euf.2019.04.002DOI Listing

Prevalence, Severity and Correlates of Symptoms of Anxiety and Depression at the Very End of Life.

J Pain Symptom Manage 2019 Apr 17. Epub 2019 Apr 17.

Weill Cornell Medicine, Division of Geriatric and Palliative Medicine, New York, NY, USA.

Context: Rates of psychological symptoms for patients with serious illness are high, but there has been limited research investigating psychological symptoms at the very end of life.

Objectives: To better understand the prevalence, severity and correlates of psychological distress at the very end of life.

Methods: This retrospective cross-sectional study utilized caregiver proxy interviews. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08853924193018
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http://dx.doi.org/10.1016/j.jpainsymman.2019.04.012DOI Listing
April 2019
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Update of the statements on biology and clinical impact of occult hepatitis b virus infection.

J Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.

In October 2018 a large number of international experts with complementary expertise came together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI). The objectives of the workshop were to review the existing knowledge on OBI, to identify issues that require further investigation, to highlight both the existing controversial and newly emerging aspects, and ultimately to update the statements previously agreed in 2008. This paper represents the output from the workshop. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193025
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http://dx.doi.org/10.1016/j.jhep.2019.03.034DOI Listing
April 2019
2 Reads

Motor Function Performance in Individuals with RYR1-Related Myopathies.

Muscle Nerve 2019 Apr 20. Epub 2019 Apr 20.

National Institute of Nursing Research, NIH, Bethesda, MD, USA.

Introduction: The purpose of this study was to obtain a 6-month natural history of motor function performance in individuals with RYR1-RM using the Motor Function Measure (MFM-32) and graded functional tests (GFTs), while facilitating preparation for interventional trials.

Methods: A total of 34 participants completed the MFM-32 and GFTs at baseline and 6-month visits.

Results: Motor deficits using MFM-32 were primarily observed in the standing and transfers domain (D1, mean 71%). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mus.26491
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http://dx.doi.org/10.1002/mus.26491DOI Listing
April 2019
1 Read

Noncoding RNA.

Microbiol Spectr 2019 Mar;7(2)

Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, F-67000 Strasbourg, France.

Regulatory RNAs, present in many bacterial genomes and particularly in pathogenic bacteria such as , control the expression of genes encoding virulence factors or metabolic proteins. They are extremely diverse and include noncoding RNAs (sRNA), antisense RNAs, and some 5' or 3' untranslated regions of messenger RNAs that act as sensors for metabolites, tRNAs, or environmental conditions (e.g. Read More

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http://www.asmscience.org/content/journal/microbiolspec/10.1
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http://dx.doi.org/10.1128/microbiolspec.GPP3-0038-2018DOI Listing
March 2019
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Predictive factors of unexpected lymphatic drainage pathways in early-stage cervical cancer.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

Objectives: The purpose of this study was to describe sentinel lymph nodes (SLN) topography in patients with early-stage cervical cancer and to determine factors associated with atypical lymphatic drainage pathway (LDP).

Methods: We analyzed the data of two prospective multicentric trials on SLN biopsy for cervical cancer (SENTICOL I and II) in women undergoing surgery for early-stage cervical cancer. SLN detection was realized with a combined labeling technique (Patent blue and radioactive tracer). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193050
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http://dx.doi.org/10.1016/j.ygyno.2019.04.008DOI Listing
April 2019
1 Read

Full tractography for detecting the position of cranial nerves in preoperative planning for skull base surgery: technical note.

J Neurosurg 2019 Apr 19:1-11. Epub 2019 Apr 19.

4Department of Neurosurgery, Stanford University Medical Center, Stanford, California.

OBJECTIVEDiffusion imaging tractography has allowed the in vivo description of brain white matter. One of its applications is preoperative planning for brain tumor resection. Due to a limited spatial and angular resolution, it is difficult for fiber tracking to delineate fiber crossing areas and small-scale structures, in particular brainstem tracts and cranial nerves. Read More

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http://dx.doi.org/10.3171/2019.1.JNS182638DOI Listing

[How I do... easily a laparoscopic isthmic cerclage?]

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Département de Gynécologie, Hôpital Femme Mère Enfant, HFME, 59 boulevard Pinel, Hospices civils de Lyon, 69000 Lyon, France.

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http://dx.doi.org/10.1016/j.gofs.2019.04.011DOI Listing

[How I do Utero-vaginal suspension using a bilateral vaginal anterior sacrospinous fixation with mesh].

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Service de Chirurgie Gynécologique, Hôpital Femme Mère Enfant, Hospices Civils de Lyon Bron, France; Université Claude Bernard Lyon 1, France.

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http://dx.doi.org/10.1016/j.gofs.2019.04.006DOI Listing

Investigating associations between pain and complicated grief symptoms in bereaved Japanese older adults.

Aging Ment Health 2019 Apr 19:1-7. Epub 2019 Apr 19.

a Brookdale Center for Healthy Aging , Hunter College of the City University of New York , New York , New York , USA.

Objectives: About 10% of those who lose a loved one in hospice or palliative care settings will experience a mental health condition characterized by severe, prolonged grief responses. Criteria for this condition have evolved; we refer to this condition as Complicated Grief (CG) because it is one of the more common names. While there are some indications of associations between CG and poor physical health, explorations of the association between CG and pain is limited. Read More

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http://dx.doi.org/10.1080/13607863.2019.1594166DOI Listing

Necrotizing Soft Tissue Infections S.aureus - but not S.pyogenes- isolates display high rate of internalization and cytotoxicity toward human myoblasts.

J Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

CIRI, Centre International de Recherche en Infectiologie, Université de Lyon; Inserm U1111; Ecole Normale Supérieure de Lyon; Université Lyon ; CNRS, UMR; Hospices Civils de Lyon ; Lyon, France.

Background: Necrotizing Soft Tissue Infections (NSTIs) caused by group A Streptococcus (GAS) and occasionally by Staphylococcus aureus (SA) frequently involve the deep fascia and often lead to muscle necrosis.

Methods: To assess the pathogenicity of GAS and SA for muscles in comparison to keratinocytes, adhesion and invasion of NSTI-GAS and NSTI-SA isolates were assessed on these cells, Bloodstream infections (BSI-SA) and non-invasive coagulase negative Staphylococci (CNS) isolates were used as controls.

Results: NSTI-SA and BSI-SA exhibited stronger internalization into human keratinocytes and myoblasts than NSTI-GAS or CNS. Read More

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http://dx.doi.org/10.1093/infdis/jiz167DOI Listing

Cannibalistic acute myeloid leukemia with ZMYND11-MBTD1 fusion.

Blood 2019 Apr;133(16):1789

Hospices Civils de Lyon.

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http://dx.doi.org/10.1182/blood-2019-01-898619DOI Listing

Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study.

Clin Nutr 2019 Apr 2. Epub 2019 Apr 2.

Nutrition Intensive Care Unit, Hospices Civil de Lyon, F-69495, Pierre Benite Cedex, France. Electronic address:

Background & Aims: Short bowel syndrome patients (SBS) receiving parenteral nutrition (PN) often have dyslipidaemia and can develop intestinal failure-associated liver disease (IFALD). These patients demonstrate increased cholesterol synthesis and hepatic lipogenesis. These lipid disturbances may be due to a decreased concentration of the bile acid pool or malabsorption. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193015
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http://dx.doi.org/10.1016/j.clnu.2019.03.037DOI Listing
April 2019
1 Read

Prognostic Value of Post-Diagnosis Health-Related Quality of Life for Overall Survival in Breast Cancer: Findings from a 10-Year Prospective Cohort in Korea.

Cancer Res Treat 2019 Apr 12. Epub 2019 Apr 12.

Center for Breast Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.

Purpose: We aimed to evaluate health-related quality of life (HRQOL) at 1-year post-diagnosis in breast cancer (BC) patients and its association with overall survival using data from the National Cancer Center Hospital.

Materials And Methods: Data of a BC cohort were first obtained between 2004 and 2006 and followed up until July 2018. HRQOL was assessed using EORTC QLQ-C30 and BC specific module QLQ-BR23 few days after diagnosis and 1 year after that. Read More

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http://dx.doi.org/10.4143/crt.2018.426DOI Listing

Feasibility Study of Physician Orders for Life-Sustaining Treatment for Patients with Terminal Cancer.

Cancer Res Treat 2019 Apr 18. Epub 2019 Apr 18.

Department of Hematology and Oncology, Ulsan University Hospital, Ulsan University College of Medicine, Ulsan, Korea.

Purpose: Physician Orders for Life-Sustaining Treatment (POLST) form is a legal document for terminally ill patients to make medical decisions with physicians near the end-of-life. A multicenter prospective study was conducted to evaluate the feasibility of POLST administration in actual oncological practice.

Materials And Methods: Patients with terminal cancer, age ≥20, and capable of communicating were eligible. Read More

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http://dx.doi.org/10.4143/crt.2019.009DOI Listing

Barriers to End-of-Life Care from Tuberculosis: A Teachable Moment.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Medicine, Boston University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1016/j.amjmed.2019.03.042DOI Listing

Higher rates of HBsAg clearance with tenofovir-containing therapy in HBV/HIV co-infection.

PLoS One 2019 18;14(4):e0215464. Epub 2019 Apr 18.

Le Trait d'Union, HIV-Infection Care Center, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Introduction: Achieving functional cure of chronic HBV infection (Hepatitis B surface antigen [HBsAg] clearance, eventually followed by acquisition of anti-hepatitis B surface antigen [Anti-HBs]) in individuals with HIV and HBV infections is a rare event. In this setting, factors related to HBV cure have not yet been fully characterized.

Methods: HIV-infected individuals with chronic HBV infection enrolled in the French Dat'AIDS cohort (NCT02898987), who started combined antiretroviral (cART)-anti-HBV treatment were retrospectively analyzed for HBsAg loss and Anti-HBs seroconversion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215464PLOS
April 2019
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Individual, clinical and system factors associated with the place of death: A linked national database study.

PLoS One 2019 18;14(4):e0215566. Epub 2019 Apr 18.

Centre for Population Health Sciences, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Background: Many middle- and high-income countries face the challenge of meeting preferences for home deaths. A better understanding of associated factors could support the design and implementation of policies and practices to enable dying at home. This study aims to identify factors associated with the place of death in Singapore, a country with a strong sense of filial piety. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215566PLOS
April 2019
1 Read

What's new this month?

Eur J Dermatol 2019 Feb;29(1):105-106

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1684/ejd.2019.3509DOI Listing
February 2019
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Accreditation of the toxicological screening: recommendations of the SFBC-SFTA group.

Ann Biol Clin (Paris) 2019 Apr;77(2):219-224

Laboratoire de pharmacologie-toxicologie, Plateforme de biologie hospitalo-universitaire, CHU Dijon, France.

Toxicological screening is a specific approach to analytical toxicology that uses analytical tools such as GC-MS, LC-UV (diode array) or LC-MS. Toxicological screening allows the detection and simultaneous identification of a large number of compounds. The results may be based on the use of one or more techniques. Read More

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http://dx.doi.org/10.1684/abc.2019.1422DOI Listing
April 2019
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Systemic pharmacokinetic/pharmacodynamic analysis of intravitreal aflibercept injection in patients with retinal diseases.

BMJ Open Ophthalmol 2019 20;4(1):e000185. Epub 2019 Mar 20.

Bayer Pharma, Berlin, Germany.

Objective: Explore relationships between systemic exposure to intravitreal aflibercept injection (IAI) and systemic pharmacodynamic effects via post hoc analyses of clinical trials of IAI for neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME).

Methods And Analysis: Adults from VGFT-OD-0702.PK (n=6), VGFT-OD-0512 (n= 5), VIEW 2 (n=1204) and VIVID-DME (n=404) studies were included. Read More

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http://dx.doi.org/10.1136/bmjophth-2018-000185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440611PMC

LRSAM1 variants and founder effect in French families with ataxic form of Charcot-Marie-Tooth type 2.

Eur J Hum Genet 2019 Apr 17. Epub 2019 Apr 17.

AP-HP, G-H Pitié-Salpêtrière, Centre de Référence des Maladies neuromusculaires, Paris Nord/Est/Ile de france, Paris, France.

Currently only 25-30% of patients with axonal forms of Charcot-Marie-Tooth disease (CMT) receive a genetic diagnosis. We aimed to identify the causative gene of CMT type 2 in 8 non-related French families with a distinct clinical phenotype. We collected clinical, electrophysiological, and laboratory findings and performed genetic analyses in four different French laboratories. Read More

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http://dx.doi.org/10.1038/s41431-019-0403-8DOI Listing

Timing of Palliative Consultation for Children During a Fatal Illness.

Hosp Pediatr 2019 Apr 17. Epub 2019 Apr 17.

Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio;

Background: The American Academy of Pediatrics recommends palliative care for children at the diagnosis of serious illness. Yet few children who die receive specialty palliative care consultation, and when it is provided, palliative care consultation tends to occur after >75% of the time from diagnosis until death. Focusing on the timing of palliative consultation in relation to the date of diagnosis, we evaluated factors predicting earlier receipt of pediatric palliative care in a cohort of decedents. Read More

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http://dx.doi.org/10.1542/hpeds.2018-0169DOI Listing

TCR activation mimics CD127PD-1 phenotype and functional alterations of T lymphocytes from septic shock patients.

Crit Care 2019 Apr 17;23(1):131. Epub 2019 Apr 17.

EA 7426 « Pathophysiology of injury-induced immunosuppression (PI3) » Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Hôpital Edouard Herriot 5 place d'Arsonval, 69003, Lyon, France.

Background: Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death. As interleukin-7 (IL-7) is currently tested in clinical trials to reverse these dysfunctions, it is important to evaluate the expression of its specific CD127 receptor on the T-cell surface of patients with septic shock. Read More

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-01
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http://dx.doi.org/10.1186/s13054-018-2305-5DOI Listing
April 2019
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Barriers and Facilitators to Preparedness for Death: Experiences of Family Caregivers of Elders with Dementia.

J Soc Work End Life Palliat Care 2019 Apr 18:1-20. Epub 2019 Apr 18.

b School of Social Work , University of Wisconsin-Madison , Madison , Wisconsin , USA.

Less is known about how caregivers prepare (or not) for the death of a family member with dementia. This study's purpose was to explore how caregivers handle these dementia deaths, including identification of barriers and facilitators to preparing caregivers for the death of an elder family member dying with dementia. This qualitative, descriptive study employed a purposive sampling strategy in which the principal investigator interviewed 36 caregivers of family members age 65 and older who died from a dementia-related diagnosis. Read More

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https://www.tandfonline.com/doi/full/10.1080/15524256.2019.1
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http://dx.doi.org/10.1080/15524256.2019.1595811DOI Listing
April 2019
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LIMPRINT: The UK Experience-Subjective Control of Swelling in Patients Attending Specialist Lymphedema Services.

Lymphat Res Biol 2019 Apr;17(2):211-220

9 Centre for Research & Implementation of Clinical Practice, London, United Kingdom.

This study was undertaken as part of the UK LIMPRINT international study to determine the number of people with chronic edema (CO) and its impact on health services. Overall 7436 with CO were recruited in the main UK study from a range of health settings. Factors relating to subjective control of arm and leg CO were defined in the UK. Read More

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http://dx.doi.org/10.1089/lrb.2019.0020DOI Listing
April 2019
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LIMPRINT in Specialist Lymphedema Services in United Kingdom, France, Italy, and Turkey.

Lymphat Res Biol 2019 Apr;17(2):141-146

4 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

There is no standardized international model for specialist lymphedema services, which covers the types of lymphedema treated and the treatments provided. The aim of this study was to provide a profile of patients attending specialist lymphedema services in different countries to explore similarities and differences. The LIMPRINT core tool was used in specialist lymphedema services in the United Kingdom, France, Italy, and Turkey. Read More

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https://www.liebertpub.com/doi/10.1089/lrb.2019.0021
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http://dx.doi.org/10.1089/lrb.2019.0021DOI Listing
April 2019
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A Systemic Approach to Complete the Multimodal Assessment Model of Pain.

Clin J Pain 2019 Apr 15. Epub 2019 Apr 15.

Lyon Public Hospices, France, Systemic Health Pathway Laboratory, Lyon, France.

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http://dx.doi.org/10.1097/AJP.0000000000000715DOI Listing

Assessing severe alteration of tissue perfusion during atrial fibrillation using of esophageal photoplethysmography.

Minerva Anestesiol 2019 Apr 16. Epub 2019 Apr 16.

Service d'Anesthésie Réanimation, Groupement Hospitalier Sud, Hospices Civils de Lyon, Pierre Bénite, France.

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http://dx.doi.org/10.23736/S0375-9393.19.13638-3DOI Listing
April 2019
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