23,689 results match your criteria Journal of Hospice & Palliative Nursing [Journal]


Introduction to a new Special Series for the Journal of Pain and Symptom Management - Science in Action: Evidence and opportunities for palliative care across diverse populations and care settings.

J Pain Symptom Manage 2019 Feb 11. Epub 2019 Feb 11.

Director of Quality and Research, American Academy of Hospice and Palliative Medicine (AAHPM), Chicago, IL.

Practices to optimize palliative care delivery and new opportunities in which to integrate palliative care vary across populations and care settings. Systematic reviews are an efficient and methodologically rigorous approach to summarize existing research to identify both evidence-based best-practices as well as new areas for future research and clinical practice. This is the introduction to a special series of articles in which members of the AAHPM Research Committee report the results of circumscribed systematic reviews which in a specific population or care setting seek to: (a) summarize existing evidence for optimal palliative care practices or (b) identify opportunities where better palliative care delivery could improve patient and/or family outcomes. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.005DOI Listing
February 2019

Comparison of Cone-Beam Computed Tomography and Multislice Computed Tomography in the Assessment of Extremity Fractures.

J Comput Assist Tomogr 2019 Feb 11. Epub 2019 Feb 11.

Emergency Department, Hôpital Edouard Herriot, Hospices Civils de Lyon.

Objectives: The aims of this study were to evaluate the agreement between cone-beam computed tomography (CBCT) and multislice computed tomography for the characterization of extremity fractures and to compare image quality, radiation dose, and patient tolerance.

Methods: Thirty-six patients with suspected fracture affecting distal extremities or who required preoperative fracture assessment were enrolled prospectively. Each patient underwent CBCT and multislice computed tomography the same day. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000843DOI Listing
February 2019

Clinical spectrum of central nervous system myelin oligodendrocyte glycoprotein autoimmunity in adults.

Curr Opin Neurol 2019 Feb 11. Epub 2019 Feb 11.

Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Hôpital Neurologique Pierre Wertheimer Hospices Civils de Lyon.

Purpose Of Review: The clinical interest for auto-antibodies against myelin oligodendrocyte glycoprotein (MOG) has recently reemerged, with the use of more specific detection methods. Large national cohorts have allowed characterizing a more precise clinical spectrum delineated by the presence of human MOG-antibodies.

Recent Findings: In adults with MOG-antibodies, optic neuritis is the most frequent clinical presentation, with features different from multiple sclerosis (MS), including bilateral involvement and predilection for the anterior part of the optic nerve. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000681DOI Listing
February 2019

Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures.

Front Immunol 2019 29;10:60. Epub 2019 Jan 29.

Virologie et Pathologie Humaine-VirPath Team, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.

Influenza virus infections remain a major and recurrent public health burden. The intrinsic ever-evolving nature of this virus, the suboptimal efficacy of current influenza inactivated vaccines, as well as the emergence of resistance against a limited antiviral arsenal, highlight the critical need for novel therapeutic approaches. In this context, the aim of this study was to develop and validate an innovative strategy for drug repurposing as host-targeted inhibitors of influenza viruses and the rapid evaluation of the most promising candidates in Phase II clinical trials. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361841PMC
January 2019

Persistence and Diffusion of C-Positive CC130 MRSA Isolates in Dairy Farms in Meurthe-et-Moselle County (France).

Front Microbiol 2019 30;10:47. Epub 2019 Jan 30.

Pathogénie des Infections à Staphylocoque, Centre International de Recherche en Infectiologie, Lyon, France.

Methicillin resistance in (MRSA) is classically conferred by the acquisition of the A gene encoding an additional penicillin binding protein with low affinity for beta-lactams. A A variant, named C, was described in 2011. MRSA isolates harboring C of both animal and human origin have since been collected in different European countries. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363682PMC
January 2019

A multifaceted small RNA modulates gene expression upon glucose limitation in .

EMBO J 2019 Feb 13. Epub 2019 Feb 13.

Architecture et Réactivité de l'ARN, CNRS, Université de Strasbourg, Strasbourg, France

Pathogenic bacteria must rapidly adapt to ever-changing environmental signals resulting in metabolism remodeling. The carbon catabolite repression, mediated by the catabolite control protein A (CcpA), is used to express genes involved in utilization and metabolism of the preferred carbon source. Here, we have identified RsaI as a CcpA-repressed small non-coding RNA that is inhibited by high glucose concentrations. Read More

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http://dx.doi.org/10.15252/embj.201899363DOI Listing
February 2019

Palliative medicine and hospital readmissions in end-stage liver disease.

BMJ Support Palliat Care 2019 Feb 13. Epub 2019 Feb 13.

Division of Gastroenterology, Department of Medicine, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada.

Background: Patients with end-stage liver disease (ESLD) have a reduced life expectancy and a significant symptom burden. Our aim is to determine if inpatient palliative care (PC) referral for patients with ESLD is associated with decreased hospital readmission rates.

Methods: The 2013 US Nationwide Readmission Database (NRD) was used for the current analysis. Read More

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http://dx.doi.org/10.1136/bmjspcare-2018-001635DOI Listing
February 2019

Attitudes toward advance directives and prognosis in patients with heart failure: a pilot study.

Korean J Intern Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Background/aims: Advance directives (ADs) in Korean patients with heart failure (HF) and the associations of attitude towards ADs and HF prognosis with ADs were initially assessed using the model of the Korean-Advance Directive (K-AD).

Methods: Twenty-four patients with HF (age, 67.1 years; men, 58. Read More

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http://kjim.org/journal/view.php?doi=10.3904/kjim.2018.158
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http://dx.doi.org/10.3904/kjim.2018.158DOI Listing
February 2019
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Palliative care physicians' perspectives on transferring patients to nursing homes and communication strategies to facilitate this transition: A qualitative study.

Palliat Med 2019 Mar;33(3):323-331

1 Centre for Learning & Research in Palliative Care, HammondCare, Sydney, NSW, Australia.

Background:: As modern medicine extends the life expectancy of patients with life-limiting illnesses and health system resource pressures intensify, palliative care physicians increasingly need to transfer stable patients from specialist palliative care units to nursing homes. The experience of palliative care physicians in decision-making and communicating with patients and families about the need for this transition is underexplored in the literature.

Aim:: This study aimed to explore the experiences of and communication techniques used by palliative care physicians as they consider and discuss nursing home placements for their patients. Read More

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http://dx.doi.org/10.1177/0269216319827803DOI Listing

Palliative Care Use Among Patients with Bladder Cancer.

BJU Int 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Objectives: To describe the rate and determinants of palliative care use among Medicare beneficiaries with bladder cancer and encourage a national dialogue on improving coordinated urologic, oncologic, and palliative care in patients with genitourinary malignancies.

Materials And Methods: Using Surveillance, Epidemiology, and End Results-Medicare data, we identified patients diagnosed with muscle-invasive bladder cancer between 2008-2013. Our primary outcome was receipt of palliative care, defined as the presence of a claim submitted by a Hospice and Palliative Medicine subspecialist. Read More

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http://dx.doi.org/10.1111/bju.14708DOI Listing
February 2019

Hospice care education needs of nursing home staff in South Korea: a cross-sectional study.

BMC Palliat Care 2019 Feb 12;18(1):20. Epub 2019 Feb 12.

The Catholic University of Korea College of Nursing, 222 Banpo-Daero, Seocho-Gu, Seoul, 06591, South Korea.

Background: While the importance of hospice care education in nursing homes is recognized, the volume of research on the specific educational needs of caregivers in hospice care in nursing homes is still lacking. This study aimed to assess educational needs in hospice care among the nursing home staff in South Korea, and to examine factors related to their education needs.

Methods: This is a cross-sectional descriptive study. Read More

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http://dx.doi.org/10.1186/s12904-019-0405-xDOI Listing
February 2019

Oral Hygiene Care in Patients With Advanced Disease: An Essential Measure to Improve Oral Cavity Conditions and Symptom Management.

Am J Hosp Palliat Care 2019 Feb 12:1049909119829411. Epub 2019 Feb 12.

1 Antea Palliative Care Unit, Rome, Italy.

Background:: Oral problems are frequent in palliative care and can cause disabling symptoms such as orofacial pain, dysgeusia, and xerostomia. Even if oral care is an essential aspect of nursing, it is often not considered as a priority, especially when various complex patients' needs have to be managed.

Objective:: The aim of this study was to describe oral conditions and evaluate the impact of standard oral care on symptom control and patient's perceived comfort in a sample of terminally ill patients. Read More

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http://dx.doi.org/10.1177/1049909119829411DOI Listing
February 2019

Aspirin in people with diabetes: Time to clean up the prescription list?

Diabetes Res Clin Pract 2019 Feb 9. Epub 2019 Feb 9.

Department of Cardiology, Dupuytren University Hospital, Limoges, France.

The effect of aspirin in primary cardiovascular (CV) prevention in people with diabetes is still a matter of debate. Recent results of ASCEND trial suggest that the absolute benefit on CV events is largely counter-balanced by the bleeding risk. However, one crucial question is whether aspirin should be maintained or withdrawn from the prescription list of those who are already under this therapy since a while ago. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.005DOI Listing
February 2019

Automatic depletion with Spectra Optia allows a safe 16% reduction of red blood cell pack consumption in exchanged sickle cell anemia patients.

Transfusion 2019 Feb 12. Epub 2019 Feb 12.

Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Equipe "Biologie vasculaire et du globule rouge", Université Claude Bernard Lyon 1, COMUE Lyon, Villeurbanne, France.

Background: Chronic red blood cell exchanges (RBCXs) are frequently used to prevent complications in patients with sickle cell anemia, but the scarcity of matched red blood cell packs (RBCPs) is a serious concern. The main goal of this study was to compare the number of RBCPs used during RBCXs between the Spectra Optia (SO) device (with the automatic depletion step) and the former Cobe Spectra (CSP) device.

Study Design And Methods: The performances and safety of 300 SO sessions using the automatic depletion step (SO/DE) in 50 patients with sickle cell anemia under a chronic transfusion program over a 1-year period were prospectively analyzed. Read More

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http://dx.doi.org/10.1111/trf.15188DOI Listing
February 2019

Palliative care specialists in hospice and hospital/community teams predominantly use low doses of sedative medication at the end of life for patient comfort rather than sedation: Findings from focus groups and patient records for I-CAN-CARE.

Palliat Med 2019 Feb 12:269216319826007. Epub 2019 Feb 12.

Division of Psychiatry, UCL, London, UK.

Background:: Little research has explored the detail of practice when using sedative medications at the end of life. One work package of the I-CAN-CARE research programme investigates this in UK palliative care.

Aims:: To investigate current practices when using sedative medication at the end of life in London, UK, by (1) qualitatively exploring the understandings of palliative care clinicians, (2) examining documented sedative use in patient records and (3) comparing findings from both investigations. Read More

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http://dx.doi.org/10.1177/0269216319826007DOI Listing
February 2019

Comfort care in trauma patients without severe head injury: In-hospital complications as a trigger for goals of care discussions.

Injury 2019 Jan 14. Epub 2019 Jan 14.

Perelman School of Medicine, University of Pennsylvania, Department of Surgery, Division of Trauma, Surgical Critical Care and Emergency Surgery, Philadelphia, PA, United States; Corporal Michael J. Crescenz VA Medical Center, Surgical Services, Section of Surgical Critical Care, Philadelphia, PA, United States. Electronic address:

Introduction: Many injured patients or their families make the difficult decision to withdraw life-sustaining therapies (WLST) following severe injury. While this population has been studied in the setting of severe traumatic brain injury (TBI), little is known about patients who undergo WLST without TBI. We sought to describe patients who may benefit from early involvement of end-of-life resources. Read More

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http://dx.doi.org/10.1016/j.injury.2019.01.024DOI Listing
January 2019

Quality Assessment of Reporting of Economic Evaluation in Cardiac Sugery: Has it Improved?

Int J Technol Assess Health Care 2019 Feb 12:1-5. Epub 2019 Feb 12.

Service de Chirurgie Cardiaque,Hôpital Cardiologique Louis Pradel,Université Claude Bernard.

Objectives: Cardiac surgery has seen substantial scientific progress over recent decades. Health economic evaluations have become important tools for decision makers to prioritize scarce health resources. The present study aimed to identify and critically appraise the reporting quality of health economic evaluations conducted in the field of cardiac surgery. Read More

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http://dx.doi.org/10.1017/S0266462318003768DOI Listing
February 2019

Pregnancy and donor-specific HLA-antibody-mediated rejection after liver transplantation: "Liaisons dangereuses"?

Transpl Immunol 2019 Feb 8. Epub 2019 Feb 8.

Etablissement Français du Sang, Lyon, France.

Background: Risk factors for the development of anti-HLA antibodies include blood transfusion, organ transplantation, and pregnancy. Humoral rejection, mediated by donor-specific anti-HLA antibodies (DSA), has been studied in all kind of solid organ transplantations, and several studies have suggested that post-liver transplantation (LT) DSA may play a role in acute and chronic rejection.

Objective: The aim of the present study was to assess the impact of pregnancy on the occurrence of DSA and the impact of DSA in a large population of young female LT recipients. Read More

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http://dx.doi.org/10.1016/j.trim.2019.02.002DOI Listing
February 2019

Does Quality of End-of-Life Care Differ by Urban-Rural Location? A Comparison of Processes and Family Evaluations of Care in the VA.

J Rural Health 2019 Feb 11. Epub 2019 Feb 11.

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania.

Purpose: Several studies have identified differences in end-of-life (EOL) care between urban and rural areas, yet little is known about potential differences in care processes or family evaluations of care. The purpose of this study was to examine the relationship between rurality of residence and quality of EOL care within the Veterans Affairs health care system.

Methods: This study was a retrospective, cross-sectional analysis of 126,475 veterans who died from October 2009 through September 2016 in inpatient settings across 151 facilities. Read More

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http://dx.doi.org/10.1111/jrh.12351DOI Listing
February 2019

CE: Original Research: New Acute Symptoms in Older Adults with Cognitive Impairment: What Should Family Caregivers Do?

Am J Nurs 2019 Feb 7. Epub 2019 Feb 7.

Melinda R. Steis is a nurse manager at the Viera Outpatient Clinic, Orlando Veterans Affairs Medical Center (VAMC), Melbourne, FL. Lynn Unruh is a professor and Varadraj Prabhu Gurupur is an assistant professor in the Department of Health Management and Informatics, College of Community Innovation and Education, University of Central Florida, Orlando. Emilia Shettian is a cofounder of Enigma Health and is based in Leesburg, FL. Meredeth Rowe is a professor in the College of Nursing, University of South Florida, Tampa. Adam Golden is associate chief of staff of research at Orlando VAMC and a professor in the Department of Internal Medicine, College of Medicine, University of Central Florida. The authors acknowledge Nadia Telemaque-Brathwaite, MBA, health care administrator and team leader at the Viera Outpatient Clinic, for her assistance with data collection. Contact author: Melinda R. Steis, The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.

Study findings support targeted interventions that facilitate early recognition and appropriate action.

Abstract: Background: When older adults with cognitive impairment develop new physical or behavioral symptoms, their family caregivers face a difficult decision: whether and when to seek professional medical care. Most family caregivers lack formal training in assessment and may have difficulty making such decisions. Read More

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http://dx.doi.org/10.1097/01.NAJ.0000554006.31272.d1DOI Listing
February 2019
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Genetic diversity and pathogenic variants as possible predictors of severity in a French sample of nonsyndromic heritable thoracic aortic aneurysms and dissections (nshTAAD).

Genet Med 2019 Feb 11. Epub 2019 Feb 11.

Hôpital Bichat, Département de Génétique, Assistance Publique-Hôpitaux de Paris, Paris, France.

Purpose: Heritable thoracic aortic aneurysms and dissections (hTAAD) are life-threatening complications of well-known syndromic diseases or underdiagnosed nonsyndromic heritable forms (nshTAAD). Both have an autosomal dominant transmission and are genetically heterogeneous. Our objective was to describe the relevance of molecular diagnosis in these patients and the contribution of each gene in nshTAAD. Read More

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http://dx.doi.org/10.1038/s41436-019-0444-yDOI Listing
February 2019
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Role of epithelial-mesenchymal transition factors in the histogenesis of uterine carcinomas.

Virchows Arch 2019 Feb 9. Epub 2019 Feb 9.

Department of Pathology, Hospices Civils de Lyon, Centre de Biologie et de Pathologie Sud, Chemin du Grand Revoyet, Université de Lyon, Université Claude Bernard Lyon I, 69495, Pierre Bénite Cedex, France.

Several subtypes of high-grade endometrial carcinomas (ECs) contain an undifferentiated component of non-epithelial morphology, including undifferentiated and dedifferentiated carcinomas and carcinosarcomas (CSs). The mechanism by which an EC undergoes dedifferentiation has been the subject of much debate. The epithelial-mesenchymal transition (EMT) is one of the mechanisms implicated in the transdifferentiation of high-grade carcinomas. Read More

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http://dx.doi.org/10.1007/s00428-019-02532-wDOI Listing
February 2019
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Bisphosphonates.

J Pain Symptom Manage 2019 Feb 6. Epub 2019 Feb 6.

University of Nottingham, Nottingham, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jpainsymman.2019.01.017DOI Listing
February 2019

Clinical spectrum of -related epileptic disorders.

Neurology 2019 Feb 8. Epub 2019 Feb 8.

From the University of Tübingen (S. Wolking, J.M., Y.G.W., H.L., J.S.), Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, Tübingen, Germany; Luxembourg Centre for Systems Biomedicine (P.M.), University of Luxembourg, Esch-sur-Alzette; Pediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G., C.M.), Children's Hospital Anna Meyer, University of Florence, Italy; Danish Epilepsy Centre (R.S.M.), Dianalund; Institute for Regional Health Services (R.S.M.), University of Southern Denmark, Odense; Department of Clinical and Experimental Epilepsy (S.B.), UCL Institute of Neurology and Epilepsy Society, UK, London; Division of Neurology (K.L.H., I.H.), Children's Hospital of Philadelphia, PA; Department of Pediatric Neurology (C.D.A.), Centre de Compétences Maladies Rares, CHU Besançon; Service de Génétique (N.C.), Hospices Civils des Lyon, Bron; GENDEV Team (N.C.), Neurosciences Research Center of Lyon, Bron, France; Neuropediatric Clinic and Clinic for Neurorehabilitation (K.S.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Beaumont Hospital (P.W.-W.), Dublin, Ireland; Department of Pediatrics, Division of Medical Genetics, Institute of Human Genetics (B.A.M.), Departments of Neurology and Pediatrics (A.N.), and Departments of Neurology and Pediatrics, and Institute of Human Genetics (M.R.C.), University of California, San Francisco; Department of Neurology (W.V.P.), University Hospitals Leuven, Belgium; Department of Pediatrics (L.L.S.), Hvidovre Hospital, Denmark; King's College Hospital (S.O., E.H., S.G., D.K.P.), London; Evelina London Children's Hospital (S.O., E.H., S.G.), London, UK; Section of Genetics (K.B., M.S.S.), Department of Pediatrics, University of Colorado and Children's Hospital Colorado, Aurora; Clinique Bernoise Montana (T.D.), Crans-Montana, Switzerland; Department of Neuropediatrics (H.M.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; National Institute for Health Research Oxford Biomedical Research Centre, Wellcome Centre for Human Genetics (A.T.P., S.J.L.K., J.C.T.) and Department of Oncology (D.V.V.), University of Oxford, UK; Epilepsy Center (M.P.C.), Health Sciences Department, San Paolo Hospital, University of Milan; Child Neuropsychiatry (F.D.), Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Italy; Departments of Neurology and Clinical Genomics (R.H.G.) and Health Sciences Research and Clinical Genomics (E.W.K., C.K.), Mayo Clinic, Rochester, MN; Ambry Genetics (Z.P.), Aliso Viejo, CA; Department of Clinical Neuroscience (S.T.), King's College London; New Medicines (M.A., D.M.), UCB Pharma, Slough, UK; Neuropediatric Clinic and Clinic for Neurorehabilitation (G.J.K.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; Research Institute for Rehabilitation, Transition and Palliation (G.J.K.), PMU Salzburg, Austria; Department of Neurology (D.H.L.), University of California, San Francisco; Neurogenetics Group (S. Weckhuysen), Center for Molecular Neurology, VIB, Antwerp; Laboratory of Neurogenetics (S. Weckhuysen), Institute Born-Bunge, University of Antwerp; Department of Neurology (S. Weckhuysen), Antwerp University Hospital, Antwerp, Belgium; Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience (D.K.P.), MRC Centre for Neurodevelopmental Disorders (D.K.P.), King's College London, UK; Evelina London Children's Hospital (D.K.P.), London, UK; Department of Neuropediatrics (I.H.), University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany; Institute of Neuroscience (R.H.T.), Henry Wellcome Building, Newcastle University; Neurology Research Group (M.I.R.), Institute of Life Science, Swansea University Medical School, Swansea, UK; Service de Génétique (G.L.), Hospices Civils des Lyon, Bron; GENDEV Team (G.L.), Neurosciences Research Center of Lyon, Bron, France; NIHR University College London Hospitals Biomedical Research Centre (S.M.S.), UCL Institute of Neurology, London, UK; Cologne Center for Genomics (D.L.), University of Cologne, Germany; Stanley Center for Psychiatric Research (D.L.) and Program in Medical and Population Genetics (D.L.), Broad Institute of MIT and Harvard, Cambridge; Psychiatric and Neurodevelopmental Genetics Unit (D.L.), Massachusetts General Hospital and Harvard Medical School, Boston.

Objective: The aim of this study was to expand the spectrum of epilepsy syndromes related to , encoding the presynaptic protein syntaxin-1B, and establish genotype-phenotype correlations by identifying further disease-related variants.

Methods: We used next-generation sequencing in the framework of research projects and diagnostic testing. Clinical data and EEGs were reviewed, including already published cases. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007089DOI Listing
February 2019
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Quality of life predicts outcome of deep brain stimulation in early Parkinson disease.

Neurology 2019 Feb 8. Epub 2019 Feb 8.

From the Département de Neurologie (W.M.M.S., A.H., T.H., F.P., Y.A., M.V.), Hôpital Pitié-Salpêtrière, Centre d'Investigation Clinique 1422, Institut du Cerveau et de la Moelle Epinière, Institut National de Santé et en Recherche Médicale, Assistance Publique Hôpitaux de Paris, France; Institute of Neurology (W.M.M.S.), Konolfingen; Department of Neurology (W.M.M.S.), University Hospital Bern and University of Bern, Switzerland; Medtronic (L.T.), Minneapolis, MN; Institute of Clinical Neuroscience & Medical Psychology and Department of Neurology (A.D., L.W.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany; Movement Disorder Unit, Neurology (P.K.), CHU Grenoble Alpes; Grenoble Institut des Neurosciences (P.K., V.F., A. Kistner), University Grenoble Alpes; Inserm U1216 (P.K., V.F., A. Kistner), Grenoble, France; Department of Clinical Neurosciences (Neurology) (P.K.), Faculty of Medicine, University of Geneva, Switzerland; Coordinating Center for clinical trials of the Philipps University of Marburg (J.R., C.S.-B.); Neurochirurgische Klinik im Neurozentrum (A.F., L.P., S.P., J. Volkmann, K.K., G.D.),Christian-Albrechts-Universität Kiel; Neurologische Klinik und Poliklinik (J. Volkmann), Universitätsklinikum Würzburg; Department of Neurology (H.S.D., M.T.B., G.R.F., L.T.), University Hospital Cologne; Research Centre Jülich (G.R.F.); Klinik für Neurologie (T.H., A. Kühn, A. Kupsch) and Klinik für Neurochirurgie (G.-H.S.), Campus Virchow, Charité-Universitätsmedizin Berlin; Praxis Kupsch (A. Kupsch), Berlin, Germany; Service de Neurochirurgie (E.S.) and Service de Neurologie (V.F.), Hôpital Michallon, Centre Hospitalo-Universitaire, Grenoble; Departments of Neurosurgery (P.P.C.), Neurology (F.O.-M., C.B.-C.), and Clinical Pharmacology (C.B.-C.), University Hospital of Toulouse; ToNIC (F.O.-M., C.B.-C.), Toulouse Neuroimaging Center, University of Toulouse, Inserm, UPS, France; Department of Neurosurgery (J. Vesper), Universitätsklinikum Düsseldorf, Germany; Departments of Neurosurgery (S.D.) and Neurology (D.M.), Rouen University Hospital and University of Rouen; INSERM U1239 (D.M.), Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Mont-Saint-Aignan; Service de Neurologie (P. Damier, P. Derkinderen), CHU Nantes, Hôpital Laënnec, France; Paracelsus-Elena-Klinik Kassel (F.S.-D., C.T.); Department of Neurosurgery (C.T.), University Medical Center Göttingen; Division of Functional and Restorative Neurosurgery and Centre for Integrative Neuroscience (A.G.), Tübingen; Abteilung für Neurologie (T.W.), Reha-Zentrum Bad Gögging, Passauer Wolf; Department for Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research (D.W.), University of Tübingen; Division of Stereotactic and Functional Neurosurgery (M.O.P.), University Medical Center Freiburg, Germany; Departments of Functional and Stereotactic Neurosurgery and Radiosurgery (J.-.M.R.) and Neurology (T.W.), Timone University Hospital, INSERM, Marseille; Institut des Sciences Cognitives Marc Jeannerod (S.T.), CNRS, UMR 5229, Université de Lyon; Centre Expert Parkinson (S.T.), Service de Neurologie C, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron; Department of Neurosurgery (P.M.), University Hospital of Neurology and Neurosurgery, Hospices Civils de Lyon, Université de Lyon; Department of Neurology (J.-L.H.), INSERM-1402, Centre Hospitalier Universitaire de Poitiers, University of Poitiers, France; and Universitätsklinikum Giessen und Marburg (L.T.), Marburg Campus, Germany.

Objective: To investigate predictors for improvement of disease-specific quality of life (QOL) after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson disease (PD) with early motor complications.

Methods: We performed a secondary analysis of data from the previously published EARLYSTIM study, a prospective randomized trial comparing STN-DBS (n = 124) to best medical treatment (n = 127) after 2 years follow-up with disease-specific QOL (39-item Parkinson's Disease Questionnaire summary index [PDQ-39-SI]) as the primary endpoint. Linear regression analyses of the baseline characteristics age, disease duration, duration of motor complications, and disease severity measured at baseline with the Unified Parkinson's Disease Rating Scale (UPDRS) (UPDRS-III "off" and "on" medications, UPDRS-IV) were conducted to determine predictors of change in PDQ-39-SI. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007037DOI Listing
February 2019
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Predictive factors and prognostic value for status epilepticus in newborns.

Eur J Paediatr Neurol 2019 Jan 29. Epub 2019 Jan 29.

Epileptology, Sleep Disorders and Functional Pediatric Neurology, Member of ERN-EpiCARE; HFME, Hospices Civils de Lyon, 59 Boulevard Pinel, Bron, France.

Objectives: To evaluate the predictive factors for status epilepticus (SE) in neonates and prognostic factors for patient outcomes in newborns suffering either isolated seizures or SE.

Methods: A retrospective single-center study from January 2010 to December 2014, included 91 newborns who had neonatal seizures. Among them, 50 newborns experienced SE and 41 newborns presented isolated seizures only. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.006DOI Listing
January 2019

Health policy for telestroke in France: A retrospective description from 2003 to 2016.

Rev Neurol (Paris) 2019 Feb 5. Epub 2019 Feb 5.

Université Lyon, université Claude-Bernard Lyon 1, HESPER EA 7425, 8, avenue Rockefeller, 69008 Lyon, France; Hospices civils de Lyon, pôle IMER, 69003 Lyon, France.

Introduction: Stroke is a public health priority in France. The use of telemedicine for stroke known as telestroke, is a safe and effective practice improving access to acute stroke care including thrombolysis. Telestroke is currently being implemented in France. Read More

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http://dx.doi.org/10.1016/j.neurol.2018.10.002DOI Listing
February 2019

What do patients and family-caregivers value from hospice care? A systematic mixed studies review.

BMC Palliat Care 2019 Feb 8;18(1):18. Epub 2019 Feb 8.

St Davids Hospice, Llandudno, North Wales, UK.

Background: It is not known which attributes of care are valued the most by those who experience hospice services. Such knowledge is integral to service development as it facilitates opportunities for continuous improvement of hospice care provision. The objectives of this mixed-studies systematic review were to explore patients' and their family carer views and experiences, to determine what they valued about adult hospice care in the UK. Read More

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http://dx.doi.org/10.1186/s12904-019-0401-1DOI Listing
February 2019

Spiritual Care in Palliative Care: A Systematic Review of the Recent European Literature.

Med Sci (Basel) 2019 Feb 7;7(2). Epub 2019 Feb 7.

Department of Medical Ethics & Health Law, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Many studies on spiritual care in palliative care are performed in the US, leaving other continents unexplored. The objective of this systematic review is to map the recent studies on spiritual care in palliative care in Europe. PubMed, CINAHL, ATLA, PsycINFO, ERIC, IBSS, Web of Science, EMBASE, and other databases were searched. Read More

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http://dx.doi.org/10.3390/medsci7020025DOI Listing
February 2019

Inpatient management of hypercalcemia portends a poor prognosis among gynecologic oncology patients: A trigger to initiate hospice care?

Gynecol Oncol Rep 2019 May 26;28:1-5. Epub 2019 Jan 26.

Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO, USA.

We aim to describe survival outcomes of gynecologic oncology inpatients treated with intravenous bisphosphonates for hypercalcemia and develop a risk stratification model that predicts decreased survival to aid with goals of care discussion. In a single-center, retrospective cohort study of gynecologic oncology patients admitted for bisphosphonate therapy for hypercalcemia. Survival from hypercalcemia to death was assessed by Kaplan-Meier method and log-rank test. Read More

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http://dx.doi.org/10.1016/j.gore.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357846PMC

Assessment of patients' self-perceived intensive care unit discomforts: Validation of the 18-item version of the IPREA.

Health Qual Life Outcomes 2019 Feb 7;17(1):29. Epub 2019 Feb 7.

Réanimation polyvalente, Hôpital Louis Pasteur, CH de Chartres, Le Coudray, France.

Background And Aims: We reported the validation of the 18-item version of the 'Inconforts des Patients de REAnimation (IPREA)' questionnaire that includes 2 new items exploring feeling depressed and shortness of breath during an intensive care unit (ICU) stay.

Methods: The validation process was integrated in a multicenter, cluster-randomized, controlled, two-parallel group study built to assess the effectiveness of a tailored multicomponent program for reducing self-perceived discomfort in the ICU. All patients aged 18 years or older who survived an ICU stay of 3 calendar days or more were eligible for inclusion. Read More

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http://dx.doi.org/10.1186/s12955-019-1101-5DOI Listing
February 2019
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CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial.

Trials 2019 Feb 7;20(1):105. Epub 2019 Feb 7.

Bangor Institute for Health & Medical Research, Bangor University, Bangor, UK.

Background: While the majority of seriously ill people wish to die at home, only half achieve this. The likelihood of someone dying at home often depends on the availability of able and willing lay carers to support them. Dying people are usually unable to take oral medication. Read More

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http://dx.doi.org/10.1186/s13063-019-3179-9DOI Listing
February 2019

Thromboembolic disease in palliative and end-of-life care: A narrative review.

Thromb Res 2019 Jan 3;175:84-89. Epub 2019 Jan 3.

Marie Curie Palliative Care Research Centre, Cardiff University, Cardiff, UK. Electronic address:

Venous thromboembolism (VTE) is both common and a potential contributor to symptom burden in patients receiving palliative and end-of-life care. Many of the VTE treatment and prophylaxis recommendations are drawn from data of clinical trials assessing conventional VTE and cancer-associated thrombosis that excluded patients receiving specialist palliative or hospice care. In this group, the epidemiology of VTE and associated outcomes, as well as the risks and benefits of treatment in keeping with a palliative approach are of growing clinical and research interest. Read More

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http://dx.doi.org/10.1016/j.thromres.2018.12.028DOI Listing
January 2019
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Post-Thrombolysis Recanalization in Stroke Referrals for Thrombectomy: Incidence, Predictors, and Prediction Scores.

Stroke 2018 12;49(12):2975–2982

From the Neurology Department (P.S., G.T., J.-L.M., J.-C.B.), INSERM U894, Sainte-Anne Hospital, Université Paris Descartes, Paris, France.

Background and Purpose—Whether all acute stroke patients with large vessel occlusion need to undergo intravenous thrombolysis before mechanical thrombectomy (MT) is debated as (1) the incidence of post-thrombolysis early recanalization (ER) is still unclear; (2) thrombolysis may be harmful in patients unlikely to recanalize; and, conversely, (3) transfer for MT may be unnecessary in patients highly likely to recanalize. Here, we determined the incidence and predictors of post-thrombolysis ER in patients referred for MT and derive ER prediction scores for trial design. Methods—Registries from 4 MT-capable centers gathering patients referred for MT and thrombolyzed either on site (mothership) or in a non MT-capable center (drip-and-ship) after magnetic resonance– or computed tomography–based imaging between 2015 and 2017. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.022335DOI Listing
December 2018

A Conceptual Framework of Palliative Care across the Continuum of Advanced Kidney Disease.

Clin J Am Soc Nephrol 2019 Feb 6. Epub 2019 Feb 6.

Division of Renal-Electrolyte, Department of General Medicine, Section of Palliative Care and Medical Ethics, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center Health System, Pittsburgh, Pennsylvania.

Kidney palliative care is a growing discipline within nephrology. Kidney palliative care specifically addresses the stress and burden of advanced kidney disease through the provision of expert symptom management, caregiver support, and advance care planning with the goal of optimizing quality of life for patients and families. The integration of palliative care principles is necessary to address the multidimensional impact of advanced kidney disease on patients. Read More

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http://dx.doi.org/10.2215/CJN.09330818DOI Listing
February 2019

A Mixed-Methods Exploration of Pediatric Intensivists' Attitudes toward End-of-Life Care in Vietnam.

J Palliat Med 2019 Feb 6. Epub 2019 Feb 6.

2 Division of Pediatric Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Although the need for palliative care is gaining recognition in Southeast Asia, knowledge about how decisions are made for children near the end of life remains sparse.

Objective: To explore pediatric intensivists' attitudes and practices surrounding end-of-life care in Vietnam.

Methods: This is a mixed-methods study conducted at a tertiary pediatric and neonatal intensive care unit in Hanoi. Read More

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http://dx.doi.org/10.1089/jpm.2018.0496DOI Listing
February 2019

The burden of illness of hepatorenal syndrome (HRS) in the United States: a retrospective analysis of electronic health records.

J Med Econ 2019 Feb 6. Epub 2019 Feb 6.

a Mallinckrodt Pharmaceuticals, Inc. , 1425 US Route 206 , Bedminster , NJ 07921 , USA.

Objectives: Hepatorenal Syndrome (HRS) is characterized by renal failure in patients with advanced chronic liver disease (CLD) and is the leading cause of hospitalizations in CLD. This study examines the clinical and economic burden, outcomes, and unmet need of HRS treatment in US hospitals.

Method: A retrospective cohort study was conducted based on a large electronic health records database (Cerner HealthFacts) with records for hospitalized HRS patients from January 2009 - June 2015. Read More

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http://dx.doi.org/10.1080/13696998.2019.1580201DOI Listing
February 2019
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The Lens Opacities Classification System III grading in irradiated uveal melanomas to characterize proton induced cataracts.

Am J Ophthalmol 2019 Feb 2. Epub 2019 Feb 2.

Department of Radiation Oncology. Centre Francois Baclesse / ARCHADE- Normandie Université. 3 Avenue du Général Harris. BP 5026. 14076 Caen. France. Electronic address:

Purpose: To evaluate the use of the Lens Opacities Classification System III Grading (LOCS III) for the characterization of radiation-induced cataract, and to correlate the proton beam projection onto the lens with cataract location and grade as defined by the LOCS III.

Design: Prospective, interventional case series METHODS: Fifty-two consecutive patients with cataract following proton therapy were included. All cataracts were graded using LOCS III. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.025DOI Listing
February 2019
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Radiochemical purity of technetium-99m-nanocolloid rhenium sulphide is not influenced by heating.

Nucl Med Commun 2019 Jan 31. Epub 2019 Jan 31.

Radiopharmacy Unit, Departement of Pharmacy, Groupement Hospitalier Est, Hospices Civils de Lyon, 59 boulevard Pinel, 69677 Bron Cedex.

Despite a mistake during the preparation of technetium-99m (Tc)-nanocolloid rhenium sulphide (Nanocis) because of lack of heating, the apparent radiochemical purity (RCP) of this product was correct. The objectives of this study were to evaluate the impact of absence of heating on the RCP of Tc-nanocolloid rhenium sulphide and the effect of heating on particle size. Five Tc-Nanocis were prepared according to the manufacturer's instructions and five others were realized without any heating step. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000988DOI Listing
January 2019

Associations Between Polypharmacy, Symptom Burden, and Quality of Life in Patients with Advanced, Life-Limiting Illness.

J Gen Intern Med 2019 Feb 4. Epub 2019 Feb 4.

Division of General Internal Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.

Background: Polypharmacy may be particularly burdensome near the end of life, as patients "accumulate" medications to treat and prevent multiple diseases.

Objective: To evaluate associations between polypharmacy, symptom burden, and quality of life (QOL) in patients with advanced, life-limiting illness (clinician-estimated, 1 month-1 year).

Design: Secondary analysis of baseline data from a trial of statin discontinuation. Read More

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http://dx.doi.org/10.1007/s11606-019-04837-7DOI Listing
February 2019

Development and characterization of Lyophilized Transparized Decellularized stroma as a replacement for living cornea in deep anterior lamellar keratoplasty.

Cell Tissue Bank 2019 Feb 4. Epub 2019 Feb 4.

Banque de Tissus et de Cellules des Hospices Civils de Lyon, Hôpital Edouard Herriot, Place d'Arsonval, 69003, Lyon, France.

Corneal disease is the second cause of blindness in developing countries, where the number of corneal grafts needed by far exceeds the number available. In industrialized countries, although corneas are generally available for keratoplasty, onto inflamed and vascularized host beds they are often rejected despite immune-suppression. A non-immunogenic, transparent, cytocompatible stroma is therefore required, which can be lyophilized for long-term conservation. Read More

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http://dx.doi.org/10.1007/s10561-018-9742-xDOI Listing
February 2019

Early polysomnographic characteristics associated with neurocognitive development at 36 months of age.

Sleep Med 2019 Jan 5. Epub 2019 Jan 5.

INSERM, UMR1153, Center for Research in Epidemiology and StatisticS (CRESS), EArly life Research on later Health Team (EARoH), Univ Paris-Descartes, Paris, France.

Background: Few studies on the relationship between sleep quantity and/or quality and cognition have been conducted among preschoolers from the healthy general population. We aimed to identify, among 3-year-old children, early polysomnography (PSG) sleep factors associated with estimated intelligence quotient (IQ) using the Weschler Preschool and Primary Scale Intelligence-III test (WPPSI-III) and its indicators: full-scale (FISQ), verbal (VIQ), and performance (PIQ) intelligence quotients.

Methods: We included full-term children from the French birth-cohort AuBE with PSG recording at term (M0) and/or six months (M6), and available WPPSI-III scores at three years. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.11.026DOI Listing
January 2019
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Medication adherence after pediatric allogeneic stem cell transplantation: Barriers and facilitators.

Eur J Oncol Nurs 2019 Feb 23;38:1-7. Epub 2018 Nov 23.

Lyon Public Hospices, Lyon, France; EA4129, Systemic Health Pathway Laboratory, Lyon, France; Pharmacy, Centre Hospital Group, Lyon, France.

Purpose: Immunosuppressive therapy following pediatric hematopoietic stem cell transplantation is essential for the patient's prognosis, as the antibioprophylaxis and the isolation measures. But medication adherence is suboptimal for children and adolescents, from 52 to 73% in literature. The aim of this study is to provide an understanding of medication adherence after pediatric allogeneic stem cell transplantation (SCT), by identifying facilitators and barriers. Read More

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http://dx.doi.org/10.1016/j.ejon.2018.11.006DOI Listing
February 2019

Safety of thalidomide and bevacizumab in patients with hereditary hemorrhagic telangiectasia.

Orphanet J Rare Dis 2019 Feb 4;14(1):28. Epub 2019 Feb 4.

VASCERN HHT Reference Center, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, and Vascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK.

Background: Hereditary hemorrhagic telangiectasia (HHT) is a multisystemic inherited vascular dysplasia that leads to nosebleeds and visceral arteriovenous malformations (AVMs). Anti-angiogenic drugs thalidomide and bevacizumab have been increasingly used off-label with variable results. The HHT working group within the ERN for Rare Multisystemic Vascular Diseases (VASCERN), developed a questionnaire-based retrospective capture of adverse events (AEs) classified using the Common Terminology Criteria for Adverse Events. Read More

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http://dx.doi.org/10.1186/s13023-018-0982-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360670PMC
February 2019
1 Read

The Development of Pathways in Palliative Medicine: Definition, Models, Cost and Quality Impact.

Healthcare (Basel) 2019 Feb 1;7(1). Epub 2019 Feb 1.

Department of Palliative Medicine & Supportive Care, Section of General Internal Medicine & Geriatrics, University Medical Center, Tulane University School of Medicine, 2000 Canal Street, New Orleans, LA 70112, USA.

Palliative Care and its medical subspecialty, known as Palliative Medicine, is the care of anyone with a serious illness. This emerging field includes Hospice and comfort care, however, it is not limited to end-of-life care. Examples of the types of serious illness that Palliative Medicine clinicians care for include and are not limited to hematologic and oncologic diseases, such as cancer, advanced heart and lung diseases (e. Read More

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http://dx.doi.org/10.3390/healthcare7010022DOI Listing
February 2019
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Angiotensin II receptor blockers, steroids and radiotherapy in glioblastoma-a randomised multicentre trial (ASTER trial). An ANOCEF study.

Eur J Cancer 2019 Feb 1;109:129-136. Epub 2019 Feb 1.

Department of Neurology, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; University Paris Diderot, Sorbonne Paris Cité, Paris, France.

Background: Glioblastomas (GBMs) induce a peritumoural vasogenic oedema impairing functional status and quality of life. Steroids reduce brain tumour-related oedema but are associated with numerous side-effects. It was reported in a retrospective series that angiotensin receptor blockers might be associated with reduced peritumoural oedema. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.025DOI Listing
February 2019

The Prevalence of Nonprescription Cannabinoid-Based Medicines in British Children's Hospices: Results of a National Survey.

J Palliat Med 2019 Feb 4. Epub 2019 Feb 4.

Martin House Children's Hospice, Wetherby, United Kingdom.

Background: Almost 50,000 children and young people are affected by life-limiting conditions in the United Kingdom, around a third of which use children's hospices. Anecdotal evidence suggests that cannabinoid-based medicines (CBMs), specifically cannabis oil (CO), are being used by families with increasing frequency to manage distressing symptoms. The use of most nonprescription CBMs in the United Kingdom remains illegal. Read More

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http://dx.doi.org/10.1089/jpm.2018.0522DOI Listing
February 2019

Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children.

Pediatr Nephrol 2019 Feb 4. Epub 2019 Feb 4.

Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from several European medical centres.

Methods: Three thousand four hundred eight measurements of GFR (mGFR) using plasma clearance of exogenous substances were performed in 2218 children aged 2-17 years. Read More

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http://dx.doi.org/10.1007/s00467-018-4185-yDOI Listing
February 2019

Prognosis of malignant pheochromocytoma and paraganglioma (MAPP-Prono study): an ENS@T retrospective study.

J Clin Endocrinol Metab 2019 Feb 1. Epub 2019 Feb 1.

Department of Nuclear Medicine and Endocrine Tumors, Gustave Roussy, Villejuif, France.

Background: Malignant pheochromocytoma and paraganglioma (MPP) are characterized by prognostic heterogeneity. Our objective was to look for prognostic parameters of overall survival in MPP patients.

Patients And Methods: Retrospective multicentric study of MPP characterized by a neck-thoraco-abdomino-pelvic CT or MRI at the time of malignancy diagnosis in European centers between 1998 and 2010. Read More

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http://dx.doi.org/10.1210/jc.2018-01968DOI Listing
February 2019
3 Reads

Spatial distribution of multiple sclerosis lesions in the cervical spinal cord.

Brain 2019 Jan 30. Epub 2019 Jan 30.

NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.

Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had limited success, however, suggesting that lesion location may be a contributor. Our aim was to explore the spatial distribution of multiple sclerosis lesions in the cervical spinal cord, with respect to clinical status. Read More

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https://academic.oup.com/brain/advance-article/doi/10.1093/b
Publisher Site
http://dx.doi.org/10.1093/brain/awy352DOI Listing
January 2019
3 Reads