6,408 results match your criteria Journal of Heart and Lung Transplantation[Journal]


Prognostic implications of serial outpatient blood pressure measurements in patients with an axial continuous-flow left ventricular assist device.

J Heart Lung Transplant 2018 Nov 15. Epub 2018 Nov 15.

Department of Medicine, Division of Cardiology, Columbia University, New York, New York, USA. Electronic address:

Background: Elevated blood pressure (BP) has been linked to adverse events during left ventricular assist device support. In this study we investigated the association between outpatient BP and stroke or suspected pump thrombosis among HeartMate II (HMII) recipients.

Methods: We retrospectively studied 220 HMII patients. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.003DOI Listing
November 2018

Impact of disease process on post-transplant outcomes: Protein-losing enteropathy in Fontan patients.

J Heart Lung Transplant 2019 Jan 15;38(1):3-4. Epub 2018 Nov 15.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1016/j.healun.2018.11.004DOI Listing
January 2019

On broader geographic sharing of donor lungs.

Authors:
Thomas M Egan

J Heart Lung Transplant 2018 Nov 30. Epub 2018 Nov 30.

Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.11.010DOI Listing
November 2018

Initial combination therapy with ambrisentan + tadalafil on pulmonary arterial hypertension‒related hospitalization in the AMBITION trial.

J Heart Lung Transplant 2018 Nov 22. Epub 2018 Nov 22.

University of California at San Diego, La Jolla, California, USA.

Background: In the randomized, double-blind, event-driven AMBITION study, initial combination therapy with ambrisentan and tadalafil was associated with a 50% reduction in risk of clinical failure (first occurrence of all-cause death, hospitalization for worsening pulmonary arterial hypertension [PAH], disease progression, or unsatisfactory long-term clinical response) vs pooled monotherapy. These results were primarily driven by a reduction in PAH-related hospitalization in the combination therapy group, although a significant effect was not observed in a post-hoc analysis of all-cause hospitalization.

Methods: The effect of initial combination therapy with ambrisentan and tadalafil in AMBITION was further explored to study PAH-related hospitalization, which was not reported in the primary publication. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.006DOI Listing
November 2018

Cell replacement in human lung bioengineering.

J Heart Lung Transplant 2018 Nov 22. Epub 2018 Nov 22.

Department of Surgery, Columbia University Medical Center, Columbia University, New York, New York, USA. Electronic address:

Background: As the number of patients with end-stage lung disease continues to rise, there is a growing need to increase the limited number of lungs available for transplantation. Unfortunately, attempts at engineering functional lung de novo have been unsuccessful, and artificial mechanical devices have limited utility as a bridge to transplant. This difficulty is largely due to the size and inherent complexity of the lung; however, recent advances in cell-based therapeutics offer a unique opportunity to enhance traditional tissue-engineering approaches with targeted site- and cell-specific strategies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183174
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http://dx.doi.org/10.1016/j.healun.2018.11.007DOI Listing
November 2018
2 Reads

Perils of bridge to transplantation in patients on continuous-flow left ventricular assist devices.

J Heart Lung Transplant 2018 Nov 22. Epub 2018 Nov 22.

Division of Cardiology, New York University Langone Health, New York, New York, USA.

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http://dx.doi.org/10.1016/j.healun.2018.11.009DOI Listing
November 2018

Predicted heart mass is the optimal metric for size match in heart transplantation.

J Heart Lung Transplant 2018 Sep 27. Epub 2018 Sep 27.

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Background: Donor-recipient size match is traditionally assessed by body weight. We assessed the ability of 5 size match metrics-predicted heart mass (PHM), weight, height, body mass index (BMI) and body surface area (BSA)-to predict 1-year mortality after heart transplant and to assess the effect of size match on donor heart turn down for size.

Methods: The study cohort comprised 19,168 adult heart transplant recipients in the United Network for Organ Sharing registry between 2007 and 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183166
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http://dx.doi.org/10.1016/j.healun.2018.09.017DOI Listing
September 2018
1 Read

Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture model.

J Heart Lung Transplant 2018 Nov 2. Epub 2018 Nov 2.

Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Biomedical Engineering, School of Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA. Electronic address:

Background: Continuous-flow ventricular assist devices (CF-VADs) produce non-physiologic flow with diminished pulsatility, which is a major risk factor for development of adverse events, including gastrointestinal (GI) bleeding and arteriovenous malformations (AVMs). Introduction of artificial pulsatility by modulating CF-VAD flow has been suggested as a potential solution. However, the levels of pulsatility and frequency of CF-VAD modulation necessary to prevent adverse events are currently unknown and need to be evaluated. Read More

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http://dx.doi.org/10.1016/j.healun.2018.10.007DOI Listing
November 2018

Outcomes from a recovery protocol for patients with continuous-flow left ventricular assist devices.

J Heart Lung Transplant 2018 Nov 15. Epub 2018 Nov 15.

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Berlin, Germany.

Background: In this retrospective analysis we evaluated a standardized echocardiographic assessment and an invasive technique for patient selection for successful continuous-flow left ventricular assist device (CF-LVAD) explantation.

Methods: Inclusion criteria for LVAD recovery assessment were: clinically stable condition; LVAD support for >6 months; physical activity; normal echocardiography findings; and no more than mild valvular disease and aortic valve opening. In a second step, echocardiography was performed under CF-LVAD reduction and stop conditions (PStopE). Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.001DOI Listing
November 2018

Time-dependent prognostic effects of recipient and donor age in adult heart transplantation.

J Heart Lung Transplant 2018 Oct 17. Epub 2018 Oct 17.

Department of Clinical Sciences Lund, Cardiothoracic Surgery, Lund University and Skane University Hospital, Lund, Sweden.

Background: Recipient age and donor age are well-known prognostic factors in adult heart transplantation. However, the association between donor age and recipient age and their interaction and short- and long-term mortality is unknown.

Methods: We studied 64,354 heart transplants to adult recipients between 1988 and 2013 in the ISHLT Registry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183170
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http://dx.doi.org/10.1016/j.healun.2018.10.003DOI Listing
October 2018
2 Reads

Freedom from chronic lung allograft dysfunction (CLAD) or CLAD-free survival: What's in a name?

J Heart Lung Transplant 2019 Jan 15;38(1):1-2. Epub 2018 Nov 15.

Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.healun.2018.11.005DOI Listing
January 2019

Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction.

J Heart Lung Transplant 2018 Oct 31. Epub 2018 Oct 31.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine; Duke Clinical Research Institute.

Background: Chronic lung allograft dysfunction (CLAD), including the phenotypes of bronchiolitis obliterans syndrome (BOS) and restrictive CLAD (R-CLAD), represents the leading cause of late death after lung transplantation. Little is known, however, regarding the natural history or prognostic significance of pulmonary function changes after the onset of these conditions. We examined changes in forced expiratory volume in 1 second (FEV) and forced vital capacity (FVC) over the first 18 months after CLAD. Read More

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http://dx.doi.org/10.1016/j.healun.2018.10.006DOI Listing
October 2018
5 Reads

Long-term outcomes after transplantation after support with a pulsatile pediatric ventricular assist device.

J Heart Lung Transplant 2018 Oct 26. Epub 2018 Oct 26.

Division of Congenital Heart Surgery, Baylor College of Medicine, Houston, TX, US.

Background: There has been increasing use of durable ventricular assist devices (VAD) in children as a bridge to transplantation (BTT). The Berlin Heart investigational device exemption (IDE) trial was the first pediatric VAD trial to demonstrate excellent survival outcomes as a BTT.

Objectives: Our aim was to compare the expanded post-transplant outcomes for children enrolled in the Berlin Heart IDE trial to a matched Pediatric Heart Transplant Study (PHTS) cohort not requiring mechanical circulatory support (MCS). Read More

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http://dx.doi.org/10.1016/j.healun.2018.10.005DOI Listing
October 2018
2 Reads

Outcomes of children with congenital heart disease implanted with ventricular assist devices: An analysis of the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs).

J Heart Lung Transplant 2018 Oct 31. Epub 2018 Oct 31.

Department of Pediatrics, Division of Pediatric Cardiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Background: The reported ventricular assist device (VAD) experience in the pediatric congenital heart disease (CHD) population is limited. We sought to describe contemporary use and outcomes of VADs in children with CHD and compare these outcomes to those of non-CHD children.

Methods: Patients enrolled in the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) between September 19, 2012 through June 30, 2017 were included. Read More

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http://dx.doi.org/10.1016/j.healun.2018.10.008DOI Listing
October 2018
3 Reads

Donor organ turn-downs and outcomes after listing for pediatric heart transplant.

J Heart Lung Transplant 2018 Sep 28. Epub 2018 Sep 28.

Pediatrics (Cardiology), University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, Texas, USA.

Background: Pediatric heart transplant waitlist mortality remains significant but allograft offer refusals are common and allografts continue to be discarded. Our aim in this study was to assess the impact of donor organ refusals on mortality after listing using a multi-institutional data set.

Methods: In this study we conducted a retrospective review of donor offers made to pediatric (<18 years) recipients in the United States in the period from 2007 to 2017. Read More

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http://dx.doi.org/10.1016/j.healun.2018.09.026DOI Listing
September 2018
4 Reads

Pre-transplant amiodarone use and outcomes in children after heart transplantation.

J Heart Lung Transplant 2018 Oct 25. Epub 2018 Oct 25.

University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1016/j.healun.2018.10.004DOI Listing
October 2018
4 Reads

Pirfenidone causes false-positive urine benzodiazepine results: Implications for patients with pulmonary fibrosis.

J Heart Lung Transplant 2018 Dec 25;37(12):1475-1477. Epub 2018 Sep 25.

Clinical Biochemistry, Alfred Pathology Service, Alfred Health, Melbourne, Victoria, Australia; School of Public Health and Preventative Medicine, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.healun.2018.09.014DOI Listing
December 2018

Increase in short-term of rejection in heart transplant patients receiving granulocyte colony-stimulating factor.

J Heart Lung Transplant 2018 Dec 27;37(12):1475. Epub 2018 Sep 27.

Department of Pharmacy, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1016/j.healun.2018.09.018DOI Listing
December 2018

The trials and tribulations of urgent lung allocation.

J Heart Lung Transplant 2018 Dec 14;37(12):1394-1396. Epub 2018 Sep 14.

Queensland Lung Transplant Service, The Prince Charles Hospital, Chermside, Brisbane, Queensland, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183165
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http://dx.doi.org/10.1016/j.healun.2018.09.008DOI Listing
December 2018
5 Reads

Lung transplantation in a patient with Niemann-Pick disease.

J Heart Lung Transplant 2019 Jan 16;38(1):100-101. Epub 2018 Oct 16.

Division of Pulmonary and Critical Care Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183170
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http://dx.doi.org/10.1016/j.healun.2018.10.002DOI Listing
January 2019
6 Reads

A newly developed transaortic axial flow ventricular assist device: Early clinical experience.

J Heart Lung Transplant 2018 Oct 2. Epub 2018 Oct 2.

Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.healun.2018.09.022DOI Listing
October 2018

Native upper lobe-sparing living-donor lobar lung transplantation maximizes respiratory function of the donor graft.

J Heart Lung Transplant 2019 Jan 25;38(1):66-72. Epub 2018 Sep 25.

Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address:

Background: We have developed a novel method for native upper lobe-sparing living-donor lobar lung transplantation (LDLLT) to overcome a small-for-size graft in standard LDLLT with acceptable results. We hypothesized that grafts implanted with this procedure might work more efficiently than those in standard lobe transplantation.

Methods: Bilateral LDLLT was performed in 31 patients with a functional graft matching of less than 60% at our institution between August 2008 and December 2015. Read More

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http://dx.doi.org/10.1016/j.healun.2018.09.012DOI Listing
January 2019
7 Reads

Usefulness of a temporary endovascular left ventricular assist system as a bridge to facilitate treatment of mediastinitis associated with a permanent device.

J Heart Lung Transplant 2018 Oct 16. Epub 2018 Oct 16.

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany; Department of Cardiothoracic Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183170
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http://dx.doi.org/10.1016/j.healun.2018.10.001DOI Listing
October 2018
6 Reads

Assessment of lung edema during ex-vivo lung perfusion by single transpulmonary thermodilution: A preliminary study in humans.

J Heart Lung Transplant 2019 Jan 1;38(1):83-91. Epub 2018 Oct 1.

Department of Anesthesiology and Operative Intensive Care Medicine, Medical Center Cologne‒Merheim, University of Witten/Herdecke, Cologne, Germany.

Background: Single transpulmonary thermodilution (SD) with extravascular lung water index (EVLWI) could become a new tool to better assess lung graft edema during ex-vivo lung perfusion (EVLP). In this study we compare EVLWI with conventional methods to better select lungs during EVLP and to predict post-transplant primary graft dysfunction (PGD).

Methods: We measured EVLWI, arterial oxygen/fraction of inspired oxygen (P/F) ratio, and static lung compliance (SLC) during EVLP in an observational study. Read More

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http://dx.doi.org/10.1016/j.healun.2018.09.019DOI Listing
January 2019
5 Reads

Rapid deployment of an aortic valve prosthesis during ventricular assist device implantation.

J Heart Lung Transplant 2018 Oct 2. Epub 2018 Oct 2.

Cardiothoracic Surgery Unit, The Alfred Hospital, Melbourne, Victoria, Australia; and; Department of Surgery, Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.healun.2018.09.023DOI Listing
October 2018

Validation of a post-transplant chronic lung allograft dysfunction classification system.

J Heart Lung Transplant 2018 Oct 4. Epub 2018 Oct 4.

Lung Transplant Unit, Department of Chronic Diseases, Metabolism & Ageing (CHROMETA), Katholieke Universiteit Leuven, Leuven, Belgium. Electronic address:

Background: Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction (CLAD). Our study evaluated the prevalence and prognostic importance of obstructive and restrictive CLAD phenotypes, with or without an identifiable underlying cause, to validate the recently proposed classification system for CLAD.

Methods: Data for patients who underwent LTx between 2004 and 2015 with a minimal survival of 180 days post-LTx were retrospectively collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183168
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http://dx.doi.org/10.1016/j.healun.2018.09.020DOI Listing
October 2018
7 Reads

Intralipid improves oxygenation after orthotopic rat lung transplantation.

J Heart Lung Transplant 2018 Sep 14. Epub 2018 Sep 14.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.healun.2018.09.006DOI Listing
September 2018
2 Reads

Outcomes of children supported with an intracorporeal continuous-flow left ventricular assist system.

J Heart Lung Transplant 2018 Sep 25. Epub 2018 Sep 25.

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: Since 2012, there has been growing use of the HeartWare (Medtronic, Mounds View, MN) intracorporeal continuous flow (CF) ventricular assist device (VAD) in children, despite it not being labeled for use in pediatric patients. We sought to describe the use and outcomes of children with HeartWare VADs.

Methods: We identified all patients aged < 19 years and young adults aged 19 to 30 years supported with HeartWare who were entered into the pediatric portion (Pedimacs) of the Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs) and the Intermacs registries, respectively, between September 2012 and June 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183166
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http://dx.doi.org/10.1016/j.healun.2018.09.015DOI Listing
September 2018
4 Reads

Obstacles to improving outcomes of heart transplantation for adults with congenital heart disease.

J Heart Lung Transplant 2019 Jan 14;38(1):107-109. Epub 2018 Sep 14.

Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.09.010DOI Listing
January 2019
1 Read

Fontan-associated protein-losing enteropathy and post‒heart transplant outcomes: A multicenter study.

J Heart Lung Transplant 2019 Jan 2;38(1):17-25. Epub 2018 Oct 2.

University of California‒San Francisco Benioff Children's Hospital, San Francisco, California, USA.

Background: The influence of Fontan-associated protein-losing enteropathy's (PLE) severity, duration, and treatment on heart transplant (HTx) outcomes is unknown. We hypothesized that long-standing PLE and PLE requiring more intensive therapy are associated with increased post-HTx mortality.

Methods: This 12-center, retrospective cohort study of post-Fontan patients with PLE referred for HTx from 2003 to 2015 involved collection of demographic, medical, surgical, and catheterization data, as well as PLE-specific data, including duration of disease, intensity/details of treatment, hospitalizations, and complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183168
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http://dx.doi.org/10.1016/j.healun.2018.09.024DOI Listing
January 2019
10 Reads

Safety and tolerability of transition from inhaled treprostinil to oral selexipag in pulmonary arterial hypertension: Results from the TRANSIT-1 study.

J Heart Lung Transplant 2019 Jan 12;38(1):43-50. Epub 2018 Sep 12.

Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.

Background: A long-term trial showed that the oral prostacyclin (PGl) receptor (IP) agonist, selexipag, delayed disease progression in patients with pulmonary arterial hypertension (PAH). Transition to selexipag in patients treated with more burdensome inhaled therapies that target the prostacyclin pathway may be considered by patients and physicians. The Phase 3b, prospective, open-label TRANSIT-1 (Tolerability and Safety of the Transition From Inhaled Treprostinil to Oral Selexipag in Patients With Pulmonary Arterial Hypertension) study evaluated the safety and tolerability of transition from inhaled treprostinil to oral selexipag. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183164
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http://dx.doi.org/10.1016/j.healun.2018.09.003DOI Listing
January 2019
3 Reads

Bronchiolitis obliterans syndrome-free survival after lung transplantation: An International Society for Heart and Lung Transplantation Thoracic Transplant Registry analysis.

J Heart Lung Transplant 2019 Jan 25;38(1):5-16. Epub 2018 Sep 25.

Divisions of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Divisions of General Medical Education, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

Background: Lung transplant (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS). However, few long-term, multicenter, and precise estimates of BOS-free survival (a composite outcome of death or BOS) incidence exist.

Methods: This retrospective cohort study of primary LTx recipients (1994-2011) reported to the International Society of Heart and Lung Transplantation Thoracic Transplant Registry assessed outcomes through 2012. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183166
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http://dx.doi.org/10.1016/j.healun.2018.09.016DOI Listing
January 2019
9 Reads

Mitochondrial transplantation prolongs cold ischemia time in murine heart transplantation.

J Heart Lung Transplant 2019 Jan 28;38(1):92-99. Epub 2018 Sep 28.

Department of Cardiac Surgery, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Background: Cold ischemia time (CIT) causes ischemia‒reperfusion injury to the mitochondria and detrimentally effects myocardial function and tissue viability. Mitochondrial transplantation replaces damaged mitochondria and enhances myocardial function and tissue viability. Herein we investigated the efficacy of mitochondrial transplantation in enhancing graft function and viability after prolonged CIT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183169
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http://dx.doi.org/10.1016/j.healun.2018.09.025DOI Listing
January 2019
8 Reads

Survival in pulmonary hypertension due to chronic lung disease: Influence of low diffusion capacity of the lungs for carbon monoxide.

J Heart Lung Transplant 2018 Sep 14. Epub 2018 Sep 14.

Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota, USA. Electronic address:

Background: Patients with pulmonary hypertension (PH) due to chronic lung disease (Group 3 PH) have poor long-term outcomes. However, predictors of survival in Group 3 PH are not well described.

Methods: We performed a cohort study of Group 3 PH patients (n = 143; mean age 65 ± 12 years, 52% female) evaluated at the University of Minnesota. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183165
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http://dx.doi.org/10.1016/j.healun.2018.09.011DOI Listing
September 2018
7 Reads

What is the role of intra-aortic balloon pump therapy in patients with acute-on-chronic heart failure and cardiogenic shock?

Authors:
Jerry D Estep

J Heart Lung Transplant 2018 Nov 31;37(11):1301-1303. Epub 2018 Jul 31.

Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio; Heart and Vascular Institute, Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.07.011DOI Listing
November 2018
2 Reads

Implications of blood group on lung transplantation rates: A propensity-matched registry analysis.

J Heart Lung Transplant 2019 Jan 25;38(1):73-82. Epub 2018 Sep 25.

Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke Medical Center, Durham, North Carolina. Electronic address:

Background: Blood type O lung allografts may be allocated to blood type identical (type O) or compatible (non-O) candidates. We tested the hypothesis that the current organ allocation schema in the United States-based on the Lung Allocation Score-prejudices against the allocation of allografts to type O candidates, given that the pool of potential donors is smaller.

Methods: We performed a retrospective cohort review of the Organ Procurement and Transplantation Network/United Network of Organ Sharing registry from May 2005 to March 2017 for adult candidates on the waiting list for first-time isolated lung transplantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183166
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http://dx.doi.org/10.1016/j.healun.2018.09.013DOI Listing
January 2019
5 Reads

Is the ratio of pulmonary artery to aortic diameter akin to heart failure's hemoglobin A1c?

J Heart Lung Transplant 2019 Jan 12;38(1):104-106. Epub 2018 Sep 12.

Division of Cardiac Surgery, UMass Memorial Medical Center, Worcester, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.09.005DOI Listing
January 2019

Risk evaluation using gene expression screening to monitor for acute cellular rejection in heart transplant recipients.

J Heart Lung Transplant 2019 Jan 12;38(1):51-58. Epub 2018 Sep 12.

Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, and Department of Medicine, Stanford University, Stanford, California. Electronic address:

Background: Gene expression profiling (GEP) was developed for non-invasive surveillance of acute cellular rejection. Despite its widespread use, there has been a paucity in outcome data for patients managed with GEP outside of clinical trials.

Methods: The Outcomes AlloMap Registry (OAR) is an observational, prospective, multicenter study including patients aged ≥ 15 years and ≥ 55 days post-cardiac transplant. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183164
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http://dx.doi.org/10.1016/j.healun.2018.09.004DOI Listing
January 2019
6 Reads

Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.

J Heart Lung Transplant 2019 Jan 14;38(1):59-65. Epub 2018 Sep 14.

Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; CRUK Manchester Institute, University of Manchester, Manchester, UK.

Background: Lung transplant recipients (LTRs) are at very high risk of skin cancer. Omega-3 fatty acids (FAs) are anti-inflammatory and immune-modulating and could potentially reduce this risk. We assessed the feasibility of omega-3 FA supplementation to reduce skin cancer among these patients. Read More

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http://dx.doi.org/10.1016/j.healun.2018.09.009DOI Listing
January 2019
6 Reads

Effect of broader geographic sharing of donor lungs on lung transplant waitlist outcomes.

J Heart Lung Transplant 2018 Sep 14. Epub 2018 Sep 14.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, California, USA.

Background: The United States lung allocation system prioritizes allocation based on medical urgency and benefit but does not address a federal mandate for broader geographic organ sharing. It is unknown whether broader geographic sharing of donor lungs would improve lung transplant waitlist outcomes.

Methods: A discrete event microsimulation model simulated donor lung allocation according to different geographic lung-sharing policies, including the historic local donor service area (DSA)-based policy and hypothetical policies that prioritize candidates to donors within 500-mile or 1,000-mile geographic radii. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183165
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http://dx.doi.org/10.1016/j.healun.2018.09.007DOI Listing
September 2018
5 Reads

Left ventricular assist device use in biventricular configurations: It takes two to tango.

J Heart Lung Transplant 2018 Dec 8;37(12):1391-1393. Epub 2018 Sep 8.

Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183164
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http://dx.doi.org/10.1016/j.healun.2018.09.001DOI Listing
December 2018
4 Reads

Influence of lung donor agonal and warm ischemic times on early mortality: Analyses from the ISHLT DCD Lung Transplant Registry.

J Heart Lung Transplant 2019 Jan 11;38(1):26-34. Epub 2018 Aug 11.

Lung Transplant Service, The Alfred Hospital, Melbourne, Victoria, Australia.

Background: In this study we aimed to assess the impact of agonal time and warm ischemic time on early survival in Category III donation-after-circulatory-death (DCD) donor lung transplants (LTxs) using data reported to the International Society for Heart and Lung Transplantation (ISHLT) DCD Lung Transplant Registry.

Methods: In this retrospective study, data were analyzed for 507 DCD LTxs done between January 2005 and June 2015. DCD lung donor agonal time (defined as withdrawal of life support to cessation of cardiac output) and warm ischemic time (WIT; defined as donor systolic blood pressure <50 mm Hg to cold pulmonary artery flush) were divided into 3 clinical timing categories (<30 minutes, 30 to 60 minutes, >60 minutes) and 3 tertiles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183159
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http://dx.doi.org/10.1016/j.healun.2018.08.006DOI Listing
January 2019
6 Reads

Response by Netuka et al regarding the article "Evaluation of low-intensity anti-coagulation with a fully magnetically levitated centrifugal-flow circulatory pump-the MAGENTUM 1 study".

J Heart Lung Transplant 2018 Oct 4;37(10):1279-1280. Epub 2018 Aug 4.

Heart and Vascular Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183157
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http://dx.doi.org/10.1016/j.healun.2018.07.017DOI Listing
October 2018
4 Reads

Frailty and clinical benefits with lung transplantation.

J Heart Lung Transplant 2018 Oct 21;37(10):1245-1253. Epub 2018 Jun 21.

Division of Respirology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada; Toronto Lung Transplant Program, University Health Network, Toronto, Ontario, Canada. Electronic address:

Background: The Fried frailty phenotype is associated with morbidity and mortality in lung transplant (LTx) candidates, but its clinical application and association with post-transplant outcomes are not well defined. We assessed 2 alternate frailty indices in LTx candidates and evaluated associations of frailty with early post-transplant outcomes and 1-year mortality.

Methods: Frailty was prospectively evaluated in 50 LTx candidates using the Fried and 2 alternate phenotypic indices, one using variables readily available to clinicians and one using variables from an existing data set. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183150
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http://dx.doi.org/10.1016/j.healun.2018.06.005DOI Listing
October 2018
5 Reads

Long-term safety and outcome of intravenous treprostinil via an implanted pump in pulmonary hypertension.

J Heart Lung Transplant 2018 Oct 21;37(10):1235-1244. Epub 2018 Jun 21.

Department of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany. Electronic address:

Background: We examined safety and long-term outcomes of intravenous treprostinil administered via the implantable LENUS Pro pump in patients with severe pulmonary hypertension (PH).

Methods: Patients with PH undergoing pump implantation between December 2009 and October 2016 in German referral centers were retrospectively analyzed (end of follow-up: May 2017). The primary objective was to determine long-term safety of the implantable pump. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183150
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http://dx.doi.org/10.1016/j.healun.2018.06.006DOI Listing
October 2018
2 Reads

Changes in renal function after left ventricular assist device placement in pediatric patients: A Pedimacs analysis.

J Heart Lung Transplant 2018 Oct 24;37(10):1218-1225. Epub 2018 Jul 24.

Department of Cardiovascular and Thoracic Surgery, UT Southwestern Medical Center, Dallas, Texas, USA.

Background: Renal dysfunction (RD) is prevalent among pediatric patients with advanced heart failure. Data are limited regarding changes in renal function after left ventricular assist device (LVAD) placement in this population.

Methods: Pediatric LVAD recipients enrolled in the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) between September 19, 2012 and June 30, 2016 were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183153
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http://dx.doi.org/10.1016/j.healun.2018.06.016DOI Listing
October 2018
9 Reads