6,454 results match your criteria Journal of Heart and Lung Transplantation[Journal]


Molecular assessment of rejection and injury in lung transplant biopsies.

J Heart Lung Transplant 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Alberta Transplant Applied Genomics Center, Edmonton, Alberta, Canada. Electronic address:

Background: Improved understanding of lung transplant disease states is essential because failure rates are high, often due to chronic lung allograft dysfunction. However, histologic assessment of lung transplant transbronchial biopsies (TBBs) is difficult and often uninterpretable even with 10 pieces.

Methods: We prospectively studied whether microarray assessment of single TBB pieces could identify disease states and reduce the amount of tissue required for diagnosis. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1317DOI Listing
February 2019

Implications of declining donor offers with increased risk of disease transmission on waiting list survival in lung transplantation.

J Heart Lung Transplant 2019 Mar 21;38(3):295-305. Epub 2018 Dec 21.

Division of Cardiovascular and Thoracic Surgery.

Background: Donors with characteristics that may increase the likelihood of disease transmission with transplantation are noted as increased risk via Public Health Service criteria. This study aimed to establish the implications of declining an increased-risk donor (IRD) organ offer in lung transplantation.

Methods: Adult candidates waitlisted for isolated lung transplantation in the United States using the Organ Procurement and Transplantation Network /United Network of Organ Sharing registry from 2007 to 2017 were identified. Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.012DOI Listing

Transplant outcomes for idiopathic pulmonary hypertension in children.

J Heart Lung Transplant 2019 Feb 5. Epub 2019 Feb 5.

Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.

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http://dx.doi.org/10.1016/j.healun.2019.01.1314DOI Listing
February 2019
1 Read

Timing of mechanically assisted circulatory support.

Authors:
Jacob Bergsland

J Heart Lung Transplant 2019 Jan 29. Epub 2019 Jan 29.

Intervention Center, Oslo University Hospital, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2019.01.1308DOI Listing
January 2019

Quality of death after left ventricular assist device implantation: More questions than answers.

J Heart Lung Transplant 2019 Jan 25. Epub 2019 Jan 25.

Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.healun.2019.01.1307DOI Listing
January 2019

Montelukast for chronic lung allograft dysfunction: Not quite the "Full Monty".

J Heart Lung Transplant 2019 Jan 30. Epub 2019 Jan 30.

Lung Transplant Unit, St. Vincent's Hospital, Sydney, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2019.01.1312DOI Listing
January 2019

Avoidance of Outflow Graft Extrinsic Compression in Polytetrafluoroethylene Reinforcements of the Bend Relief Component.

J Heart Lung Transplant 2019 Jan 29. Epub 2019 Jan 29.

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Germany; Department of Cardiothoracic Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.

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http://dx.doi.org/10.1016/j.healun.2019.01.1311DOI Listing
January 2019

A comparison of low and standard anti-coagulation regimens in extracorporeal membrane oxygenation.

J Heart Lung Transplant 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgery, George Washington University Medical Center, Washington, DC.

Background: Bleeding and need for blood products are major complications associated with extracorporeal membrane oxygenation (ECMO) use. This study evaluated bleeding complications with low and standard heparinization protocols in the maintenance of venoarterial (VA)-ECMO.

Methods: A retrospective comparison was performed of 2 methods of heparinization in a contemporaneous series of adult patients supported with VA-ECMO at Rush University Medical Center, between November 2011 and November 2016. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1313DOI Listing
January 2019

Blood pressure in a mechanically assisted circulation: "Heat, spirit, perfection".

J Heart Lung Transplant 2019 Jan 25. Epub 2019 Jan 25.

Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1016/j.healun.2019.01.1309DOI Listing
January 2019

Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry.

J Heart Lung Transplant 2019 Jan 17. Epub 2019 Jan 17.

James and John Kirklin Institute for Research in Surgical Outcomes (KIRSO), University of Alabama, Birmingham, Alabama.

Background: Despite advances in device technology and treatment strategies, infection remains a major cause of adverse events (AEs) in mechanical circulatory support (MCS) patients. To characterize the epidemiology of MCS infection, we examined the type, location, and timing of infection in the International Society for Heart and Lung Transplantation Registry (ISHLT) for Mechanically Assisted Circulatory Support (IMACS) over 3 years, 2013 to 2015.

Methods: Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) definitions were used to categorize AE infections occurring in MCS patients within IMACS. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.007DOI Listing
January 2019
1 Read

Exercise cardiovascular magnetic resonance imaging allows differentiation of low-risk pulmonary arterial hypertension.

J Heart Lung Transplant 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address:

Background: Patients with pulmonary arterial hypertension (PAH) have a decreased ability to compensate for demands on increased cardiac output, such as during exercise. In this study we aimed to differentiate cardiac exercise responses in patients with PAH, stratified according to known measurements of disease severity.

Methods: Right and left ventricular end-diastolic volume and end-systolic volume, stroke volume (SV), and cardiac output were measured in 20 patients with PAH and a lower risk of mortality with 6-month intervals using cardiovascular magnetic resonance (CMR) imaging during rest and during ergometer exercise (totaling 44 scans). Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1305DOI Listing
January 2019
1 Read

Incidence, predictors, and outcomes after severe primary graft dysfunction in pediatric heart transplant recipients.

J Heart Lung Transplant 2019 Jan 24. Epub 2019 Jan 24.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Pediatrics. Electronic address:

Background: Previous reports of primary graft dysfunction (PGD) in pediatric heart transplant (HT) recipients are limited to descriptive series of children who required extracorporeal membrane oxygenation (ECMO) support shortly after HT. In this study we sought to determine the incidence, risk factors, and survival after severe PGD in pediatric HT recipients.

Methods: We identified all children <18 years old who underwent HT in the United States during 1996 to 2015 using the Organ Procurement and Transplant Network database and then identified those who developed severe PGD by linking patient variables to Extracorporeal Life Support Organization registry data. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1310DOI Listing
January 2019

Outcomes in cystic fibrosis lung transplant recipients infected with organisms labeled as pan-resistant: An ISHLT Registry‒based analysis.

J Heart Lung Transplant 2019 Jan 25. Epub 2019 Jan 25.

Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California, USA. Electronic address:

Background: The presence of pan-resistant organisms in patients with cystic fibrosis (CF) potentially impacts mortality after lung transplant (LT). In this study we aimed to study LT mortality in CF patients with and without pan-resistant infection.

Methods: The International Society for Heart and Lung Transplantation (ISHLT) Thoracic Transplant Registry was used to identify adults with CF, first-time, bilateral LT from 1991 to 2015. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1306DOI Listing
January 2019
2 Reads

The evolving classification of chronic lung allograft dysfunction: Phenotypes and causes known and unknown.

J Heart Lung Transplant 2019 Jan 15. Epub 2019 Jan 15.

Pulmonary Division, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2019.01.008DOI Listing
January 2019

Pulmonary cuff dysfunction after lung transplant surgery: A systematic review of the evidence and analysis of its clinical implications.

J Heart Lung Transplant 2019 Jan 7. Epub 2019 Jan 7.

Department of Anesthesiology, The Ohio State University Wexner Medical Center. Electronic address:

Background: Pulmonary cuff dysfunction, either due to pulmonary vein obstruction, pulmonary vein stenosis, or pulmonary vein thrombosis, is an uncommon, yet serious complication after lung transplantation. Although there have been numerous reports of its occurrence, there is little consensus regarding the hemodynamic parameters associated with its presentation and diagnostic considerations. This systematic review summarizes the evidence surrounding pulmonary cuff dysfunction after lung transplantation surgery and empirically analyzes its implications. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.005DOI Listing
January 2019
1 Read

Hydroxocobalamin treatment of refractory vasoplegia in patients with mechanical circulatory support.

J Heart Lung Transplant 2019 Jan 7. Epub 2019 Jan 7.

Department of Anesthesiology and Perioperative Medicine.

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http://dx.doi.org/10.1016/j.healun.2019.01.003DOI Listing
January 2019

Infectious complications after heart transplantation in patients screened with gene expression profiling.

J Heart Lung Transplant 2019 Jan 7. Epub 2019 Jan 7.

Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Department of Medicine, Stanford University, Stanford, California, USA. Electronic address:

Background: The risk of infection after heart transplantation is highest within the first year and represents the leading cause of early mortality. In this cohort of patients enrolled in the Outcomes AlloMap Registry (OAR), we sought to describe infection episodes (IEp) resulting in hospitalization, in the early (<1 year) and late (≥1 year) post-transplant period and determine the impact of immunosuppression on incidence of infection.

Methods: The primary aim was to assess the incidence and nature of IEp. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.006DOI Listing
January 2019

The revolutionary nature of pediatric continuous-flow miniaturized devices.

Authors:
Antonio Loforte

J Heart Lung Transplant 2019 Jan 9. Epub 2019 Jan 9.

Department of Cardiothoracic, Transplantation and Vascular Surgery, S. Orsola Hospital, Bologna University, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.11.016DOI Listing
January 2019
1 Read

ERRATUM.

Authors:

J Heart Lung Transplant 2019 Feb;38(2):233

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http://dx.doi.org/10.1016/j.healun.2018.11.012DOI Listing
February 2019

Use of an implantable wireless pulmonary pressure monitor during transition of therapy in pulmonary arterial hypertension.

J Heart Lung Transplant 2019 Feb 24;38(2):227-230. Epub 2018 Nov 24.

Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.healun.2018.11.011DOI Listing
February 2019

Development of a transplant injection device for optimal distribution and retention of human induced pluripotent stem cell‒derived cardiomyocytes.

J Heart Lung Transplant 2019 Feb 15;38(2):203-214. Epub 2018 Nov 15.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Background: Induced pluripotent stem cell (iPSC)‒based regenerative therapy is a promising strategy for cardiovascular disease treatment; however, the method is limited by the myocardial retention of grafted iPSCs. Thus, an injection protocol that efficiently introduces and retains human iPSC-derived cardiomyocytes (hiPSC-CMs) within the myocardium is urgently needed. The objective of the present study was to develop a method to improve the retention of hiPSCs in the myocardium for cardiac therapy. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.002DOI Listing
February 2019
1 Read

Sizing it up in heart transplantation: Time to change the guidelines?

J Heart Lung Transplant 2019 Feb 14;38(2):133-135. Epub 2018 Dec 14.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.12.004DOI Listing
February 2019
2 Reads

Diffusion capacity of the lung-a disease biomarker linking ventilation and circulation.

J Heart Lung Transplant 2019 Feb 1;38(2):130-132. Epub 2018 Dec 1.

Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.11.008DOI Listing
February 2019

The Society of Thoracic Surgeons Intermacs database annual report: Evolving indications, outcomes, and scientific partnerships.

J Heart Lung Transplant 2019 Feb;38(2):114-126

Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

Background: The Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs), a joint effort among the National Heart, Lung, and Blood Institute, the Food and Drug Administration, the Centers for Medicare and Medicaid Services, and others, was established in 2005 at the University of Alabama at Birmingham. The registry examined clinical outcomes and quality-of-life metrics of patients who received an Food and Drug Administration-approved durable mechanical circulatory support (MCS) device to treat advanced heart failure. On January 1, 2018, the Intermacs Database became part of The Society of Thoracic Surgeons National Database, providing additional resources for quality assessment and improvement and scientific advancement. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.013DOI Listing
February 2019
1 Read

Azithromycin and early allograft function after lung transplantation: A randomized, controlled trial.

J Heart Lung Transplant 2019 Mar 14;38(3):252-259. Epub 2018 Dec 14.

Lung Transplant Unit, Department of Chronic Diseases, Metabolism & Ageing. Electronic address:

Background: Chronic lung allograft dysfunction (CLAD) is the single most important factor limiting long-term survival after lung transplantation (LTx). Azithromycin has been shown to improve CLAD-free and long-term survival, yet the possible impact on early lung allograft function is unclear.

Methods: A prospective, randomized, double-blind, placebo-controlled trial of pre-transplant and prompt post-transplant azithromycin treatment was performed at the University Hospitals Leuven. Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.006DOI Listing
March 2019
1 Read

Thrombotic events with proliferation signal inhibitor‒based immunosuppression in cardiac transplantation.

J Heart Lung Transplant 2019 Jan 7. Epub 2019 Jan 7.

WVU Medicine, Morgantown, West Virginia, USA.

Background: Some literature exists potentially linking proliferation signal inhibitors (PSIs) to venous thromboembolism (VTE). We sought to determine the impact of PSIs on development of VTE in heart transplant (HT) patients while controlling for other risk factors.

Methods: The incidence and predisposing factors of VTE were analyzed in this retrospective review of patients >18 years who underwent HT January 2000 to October 2016. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.004DOI Listing
January 2019
2 Reads

Stiff left atrial syndrome and heart transplantation.

J Heart Lung Transplant 2018 Dec 28. Epub 2018 Dec 28.

Heart Transplant Unit, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.healun.2018.12.017DOI Listing
December 2018
3 Reads

Association between angiotensin II antagonism and gastrointestinal bleeding on left ventricular assist device support.

J Heart Lung Transplant 2018 Dec 28. Epub 2018 Dec 28.

Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1016/j.healun.2018.12.018DOI Listing
December 2018
1 Read

Novel bacteriophage therapy for treatment of left ventricular assist device infection.

J Heart Lung Transplant 2019 Jan 7. Epub 2019 Jan 7.

Division of Infectious Diseases and Global Public Health, Department of Medicine, and University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1016/j.healun.2019.01.001DOI Listing
January 2019
2 Reads

Successful lung transplantation in a patient with Niemann‒Pick disease.

J Heart Lung Transplant 2019 Jan 7. Epub 2019 Jan 7.

Department of Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1016/j.healun.2019.01.002DOI Listing
January 2019
3 Reads

Can virtual heart transplantation via 3-dimensional imaging increase the maximum acceptable donor size?

J Heart Lung Transplant 2019 Mar 21;38(3):331-333. Epub 2018 Dec 21.

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.healun.2018.12.014DOI Listing
March 2019
4 Reads

Impact of organ prioritization for immunologic sensitization and waiting times for heart transplantation.

J Heart Lung Transplant 2019 Mar 21;38(3):285-294. Epub 2018 Dec 21.

Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address:

Background: The Canadian status 4S category prioritizes highly sensitized patients with a calculated panel reactive antibody (CPRA) > 80% awaiting heart transplantation. We examined the effect of sensitization and status 4S and developed a predictive model to estimate waiting time in Canada.

Methods: A retrospective review was performed of patients listed for heart transplant at the Ottawa Heart Institute and Toronto General Hospital (Ontario, Canada). Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.016DOI Listing
March 2019
3 Reads

Mitochondrial integrity during early reperfusion in an isolated rat heart model of donation after circulatory death-consequences of ischemic duration.

J Heart Lung Transplant 2018 Dec 21. Epub 2018 Dec 21.

Department of Cardiovascular Surgery, Inselspital, University Hospital Bern, Bern, Switzerland; Department for BioMedical Research, University of Bern, Bern, Switzerland.

Background: Cardioprotection and graft evaluation after ischemia-reperfusion (IR) are essential in facilitating heart transplantation with donation after circulatory death. Given the key role of mitochondria in IR, we aimed to investigate the tolerance of cardiac mitochondria to warm, global ischemia and to determine the predictive value of early reperfusion mitochondria-related parameters for post-ischemic cardiac recovery.

Methods: Isolated, working rat hearts underwent 0, 21, 24, 27, 30, or 33 minutes of warm, global ischemia, followed by 60 minutes of reperfusion. Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.013DOI Listing
December 2018
4 Reads

End of life for patients with left ventricular assist devices: Insights from INTERMACS.

J Heart Lung Transplant 2018 Dec 15. Epub 2018 Dec 15.

Section of Advanced Heart Failure and Transplantation, Division of Cardiology, Department of Medicine; Adult and Child Consortium for Health Outcomes Research and Delivery Science, University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: Trial and registry data have reported mortality rates and causes of death in patients with left ventricular assist devices (LVADs); however, a more granular description is needed of end of life, including location of death and quality of life (QOL), to better guide expectations and care.

Methods: To identify where patients with an LVAD died, characterize QOL before death, and cause of death over time, we evaluated patients in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) implanted with a continuous-flow LVAD.

Results: From 18,733 patients implanted with an LVAD during the period 2008 to 2016, 4,916 patients were known to have died, of whom 98% had a recorded location of death. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183178
Publisher Site
http://dx.doi.org/10.1016/j.healun.2018.12.008DOI Listing
December 2018
6 Reads

Exosomal profiling in cardiac allograft rejection: Best basic science article in 2018.

J Heart Lung Transplant 2019 Mar 21;38(3):334-336. Epub 2018 Dec 21.

Division of Cardiovascular Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.healun.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379143PMC
March 2019
1 Read

Feasibility of lung microdialysis to assess metabolism during clinical ex vivo lung perfusion.

J Heart Lung Transplant 2019 Mar 20;38(3):267-276. Epub 2018 Dec 20.

Department of Medical and Surgical Science and Biotechnologies, Sapienza University of Rome, Rome, Italy.

Background: Lung metabolism during ex vivo lung perfusion (EVLP) is increasingly studied. Microdialysis (MD) allows metabolic monitoring by sampling parenchymal interstitial fluid. This study investigated lung metabolism using MD during EVLP and evaluated whether microdialysate metabolites could improve selection and discriminate outcome of donor lungs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498183179
Publisher Site
http://dx.doi.org/10.1016/j.healun.2018.12.015DOI Listing
March 2019
7 Reads

Validation of the International Society for Heart and Lung Transplantation primary graft dysfunction instrument in heart transplantation.

J Heart Lung Transplant 2019 Mar 18;38(3):260-266. Epub 2018 Dec 18.

Ted Rogers Centre for Heart Research, Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

Background: In 2014, the International Society for Heart and Lung Transplantation (ISHLT) developed a classification instrument for left ventricular (LV) and isolated right ventricular (RV) primary graft dysfunction post‒heart transplant. The instrument classifies LV-PGD as mild, moderate, or severe. In this study, we evaluated the predictive validity of this instrument. Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.007DOI Listing
March 2019
2 Reads

Montelukast in chronic lung allograft dysfunction after lung transplantation.

J Heart Lung Transplant 2018 Dec 6. Epub 2018 Dec 6.

Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases, Metabolism & Ageing, Division of Respiratory Diseases, KU Leuven, Leuven, Belgium.

Background: Chronic lung allograft dysfunction (CLAD) is a major cause of post‒lung transplant mortality, with limited medical treatment options. In this study we assessed the association of montelukast treatment with pulmonary function and outcome in lung transplant recipients with progressive CLAD.

Methods: We performed a retrospective study of all lung transplant recipients transplanted between July 1991 and December 2016 at our center and who were treated for at least 3 months with montelukast for progressive CLAD, despite at least 3 months of prior azithromycin therapy. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.014DOI Listing
December 2018
2 Reads

Hypothermic perfusion of donor heart with a preservation solution supplemented by mesenchymal stem cells.

J Heart Lung Transplant 2019 Mar 6;38(3):315-326. Epub 2018 Dec 6.

Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany.

Background: Heart transplantation is the definitive treatment for end-stage heart failure. A shortage of donor hearts forced transplant programs to accept older donors and longer ischemic times. Previous studies have suggested that administration of mesenchymal stem cells (MSCs) or their conditioned medium (CM) protects the heart against ischemia/reperfusion injury (IRI). Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.003DOI Listing
March 2019
2 Reads

Cardiac allograft vasculopathy and graft failure in pediatric heart transplant recipients after rejection with severe hemodynamic compromise.

J Heart Lung Transplant 2019 Mar 21;38(3):277-284. Epub 2018 Dec 21.

Division of Cardiology, Children's Hospital Colorado, University of Colorado, Aurora, Colorado.

Background: Rejection with severe hemodynamic compromise (RSHC) carries a mortality risk approaching 50%. We aimed to identify current risk factors for RSHC and predictors of graft failure after RSHC.

Methods: Data from 3,259 heart transplant (HT) recipients between January 2005 and December 2015 in the Pediatric Heart Transplant Study (PHTS) were analyzed. Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.011DOI Listing
March 2019
1 Read

International Society of Heart and Lung Transplantation position statement on the role of right heart catheterization in the management of heart transplant recipients.

J Heart Lung Transplant 2019 Mar 21;38(3):235-238. Epub 2018 Dec 21.

The Pauley Heart Center, Virginia Commonwealth University Medical Center, Richmond, Virginia.

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http://dx.doi.org/10.1016/j.healun.2018.12.009DOI Listing
March 2019
2 Reads

Interrater agreement in the diagnosis of chronic lung allograft dysfunction after lung transplantation.

J Heart Lung Transplant 2019 Mar 7;38(3):327-328. Epub 2018 Dec 7.

Division of Allergy and Infectious Diseases.

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http://dx.doi.org/10.1016/j.healun.2018.12.002DOI Listing
March 2019
2 Reads

The added value of cardiopulmonary exercise testing in the follow-up of pulmonary arterial hypertension.

J Heart Lung Transplant 2019 Mar 6;38(3):306-314. Epub 2018 Dec 6.

Department of Cardiovascular and Respiratory Sciences, Sapienza University of Rome, Rome, Italy.

Background: The added value of cardiopulmonary exercise testing (CPET) in the follow-up of patients with stable pulmonary arterial hypertension (PAH) remains undefined.

Methods: Idiopathic, heritable, and drug-induced PAH patients free from clinical worsening (CW) after 1 year of treatment were enrolled in derivation (n = 80) and validation (n = 80) cohorts at an interval of 6 years and followed for 3 years. Prognostic models were constructed and validated in low-risk patients in World Health Organization (WHO) Functional Class I or II with cardiac index (CI) ≥2. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.015DOI Listing
March 2019
1 Read

Capillary density in right ventricular myocardium in congenital heart disease.

J Heart Lung Transplant 2019 Mar 7;38(3):328-331. Epub 2018 Dec 7.

Paris-Saclay University, School of Medicine, Kremlin-Bicêtre, France; Surgical Research Lab; Department of Thoracic and Vascular Surgery and Heart‒Lung Transplantation, DHU Thorax Innovation, Marie Lannelongue Hospital, Le Plessis Robinson, France.

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http://dx.doi.org/10.1016/j.healun.2018.12.001DOI Listing
March 2019
1 Read

Utilization of organs to pediatric heart transplant recipients.

J Heart Lung Transplant 2019 Mar 14;38(3):239-240. Epub 2018 Dec 14.

Swisstransplant, the Swiss National Foundation for Organ Donation and Transplantation, Bern, Switzerland.

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http://dx.doi.org/10.1016/j.healun.2018.12.005DOI Listing
March 2019
3 Reads

Continuing the battle against cardiac allograft vasculopathy: Does immunosuppression matter or is it a lipid issue?

Authors:
Vivek Rao

J Heart Lung Transplant 2019 Jan 12;38(1):102-103. Epub 2018 Sep 12.

Cardiovascular Surgery, Peter Munk Cardiac Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.09.002DOI Listing
January 2019
1 Read

Prognostic implications of serial outpatient blood pressure measurements in patients with an axial continuous-flow left ventricular assist device.

J Heart Lung Transplant 2018 Nov 15. Epub 2018 Nov 15.

Department of Medicine, Division of Cardiology, Columbia University, New York, New York, USA. Electronic address:

Background: Elevated blood pressure (BP) has been linked to adverse events during left ventricular assist device support. In this study we investigated the association between outpatient BP and stroke or suspected pump thrombosis among HeartMate II (HMII) recipients.

Methods: We retrospectively studied 220 HMII patients. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.003DOI Listing
November 2018
1 Read

Impact of disease process on post-transplant outcomes: Protein-losing enteropathy in Fontan patients.

J Heart Lung Transplant 2019 Jan 15;38(1):3-4. Epub 2018 Nov 15.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1016/j.healun.2018.11.004DOI Listing
January 2019
1 Read

On broader geographic sharing of donor lungs.

Authors:
Thomas M Egan

J Heart Lung Transplant 2019 Feb 30;38(2):127-129. Epub 2018 Nov 30.

Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address:

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February 2019
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Initial combination therapy with ambrisentan + tadalafil on pulmonary arterial hypertension‒related hospitalization in the AMBITION trial.

J Heart Lung Transplant 2019 Feb 22;38(2):194-202. Epub 2018 Nov 22.

University of California at San Diego, La Jolla, California, USA.

Background: In the randomized, double-blind, event-driven AMBITION study, initial combination therapy with ambrisentan and tadalafil was associated with a 50% reduction in risk of clinical failure (first occurrence of all-cause death, hospitalization for worsening pulmonary arterial hypertension [PAH], disease progression, or unsatisfactory long-term clinical response) vs pooled monotherapy. These results were primarily driven by a reduction in PAH-related hospitalization in the combination therapy group, although a significant effect was not observed in a post-hoc analysis of all-cause hospitalization.

Methods: The effect of initial combination therapy with ambrisentan and tadalafil in AMBITION was further explored to study PAH-related hospitalization, which was not reported in the primary publication. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.006DOI Listing
February 2019
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