6,477 results match your criteria Journal of Heart and Lung Transplantation[Journal]


Left ventricular lusitropy and primary graft dysfunction in lung transplantation.

J Heart Lung Transplant 2019 Apr 4. Epub 2019 Apr 4.

Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.healun.2019.03.013DOI Listing

Usefulness of standard computed tomography pulmonary angiography performed for acute pulmonary embolism for identification of chronic thromboembolic pulmonary hypertension: results of the InShape III study.

J Heart Lung Transplant 2019 Mar 15. Epub 2019 Mar 15.

Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is often diagnosed after a long delay, even though signs may already be present on the computed tomography pulmonary angiogram (CTPA) used to diagnose a preceding acute pulmonary embolism (PE). In this setting of suspected acute PE, we evaluated the diagnostic accuracy of dedicated CTPA reading for the diagnosis of already existing CTEPH.

Methods: Three blinded expert radiologists scored radiologic signs of CTEPH on initial CTPA scans with confirmed acute PE in 50 patients who were subsequently diagnosed with CTEPH during follow-up (cases), and in 50 patients in whom sequential echocardiograms performed >2years after the acute PE diagnosis did not show any signs of pulmonary hypertension (controls). Read More

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http://dx.doi.org/10.1016/j.healun.2019.03.003DOI Listing
March 2019
1 Read

Cancer incidence in patients with pre-capillary pulmonary hypertension.

J Heart Lung Transplant 2019 Mar 15. Epub 2019 Mar 15.

CHU de St-Etienne, Service de Médecine Vasculaire et Thérapeutique, Saint-Etienne, France; INSERM, UMR1059, Equipe Dysfonction Vasculaire et Hémostase, Université Jean-Monnet, Saint-Etienne, France; INSERM, CIC-1408, CHU Saint-Etienne, Saint-Etienne, France.

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http://dx.doi.org/10.1016/j.healun.2019.03.007DOI Listing

Heart transplantation from donation-after-circulatory-death (DCD) donors: Back to the future-Evolving trends in heart transplantation from DCD donors.

J Heart Lung Transplant 2019 Mar 26. Epub 2019 Mar 26.

Cardiothoracic Surgery & Transplantation, Alfred Heart & Lung, The Alfred Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.healun.2019.03.010DOI Listing
March 2019
1 Read

Stroke and death risk in ventricular assist device patients varies by ISHLT infection category: An INTERMACS analysis.

J Heart Lung Transplant 2019 Feb 12. Epub 2019 Feb 12.

Department of Heart Failure and Transplantation, Henry Ford Medical Center, Detroit, Michigan, USA.

Background: Ventricular assist device (VAD) patients often experience infections, which increase the risk of stroke and mortality. Using the definitions of the International Society for Heart and Lung Transplantation (ISHLT), we have characterized differences in clinical outcomes for categories of infection: VAD-specific (e.g. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498193136
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http://dx.doi.org/10.1016/j.healun.2019.02.006DOI Listing
February 2019
7 Reads

Differential effects of ischemia/reperfusion on endothelial function and contractility in donation after circulatory death.

J Heart Lung Transplant 2019 Mar 13. Epub 2019 Mar 13.

Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, Bern, Switzerland; Department for BioMedical Research, University of Bern, Bern, Switzerland.

Background: Donation after circulatory death (DCD) could significantly improve cardiac graft availability. However, DCD hearts undergo potentially deleterious warm ischemia/reperfusion (I/R). As endothelial damage is a key factor in cardiac I/R injury, we aimed to investigate the tolerance of cardiac and endothelial function after various durations of warm ischemia to improve the timing and choice of cardioprotective therapies. Read More

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http://dx.doi.org/10.1016/j.healun.2019.03.004DOI Listing
March 2019
1 Read

Outcomes with ambulatory advanced heart failure from the Medical Arm of Mechanically Assisted Circulatory Support (MedaMACS) Registry.

J Heart Lung Transplant 2019 Apr 1;38(4):408-417. Epub 2018 Oct 1.

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Background: The outlook for ambulatory patients with advanced heart failure (HF) and the appropriate timing for left ventricular assist device (LVAD) or transplant remain uncertain. The aim of this study was to better understand disease trajectory and rates of progression to subsequent LVAD therapy and transplant in ambulatory advanced HF.

Methods: Patients with advanced HF who were New York Heart Association (NYHA) Class III or IV and Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) Profiles 4 to 7, despite optimal medical therapy (without inotropic therapy), were enrolled across 11 centers and followed for the end-points of survival, transplantation, LVAD placement, and health-related quality of life. Read More

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http://dx.doi.org/10.1016/j.healun.2018.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452871PMC
April 2019
3 Reads

Surgical treatment of late left ventricular assist device outflow obstruction due to extrinsic compression.

J Heart Lung Transplant 2019 Apr 12;38(4):472-474. Epub 2019 Feb 12.

Department of Advanced Cardiopulmonary Therapies and Transplantation, McGovern Medical School, University of Texas Health Science Center‒Houston and Memorial Hermann Hospital at Texas Medical Center, Houston, Texas, USA.

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http://dx.doi.org/10.1016/j.healun.2019.02.003DOI Listing
April 2019
2 Reads

Ventricular assist device support for complex congenital heart disease: Inspiration from history of surgical evolution.

Authors:
Iki Adachi

J Heart Lung Transplant 2019 Apr 16;38(4):431-432. Epub 2019 Feb 16.

Department of Cardiovascular Surgery, Texas Children's Hospital, Houston, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2019.02.007DOI Listing

Third Annual Report From the ISHLT Mechanically Assisted Circulatory Support Registry: A comparison of centrifugal and axial continuous-flow left ventricular assist devices.

J Heart Lung Transplant 2019 Apr;38(4):352-363

University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: The IMACS Registry compiles and analyzes worldwide data from patients undergoing implantation of durable left ventricular assist devices.

Methods: Data encompassing 16,286 LVAD recipients from 4 collectives and 24 individual hospitals was collected and analyzed. In this 3rd annual report we compare and contrast outcomes, adverse events and risks factors between axial flow and centrifugal flow device recipients. Read More

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http://dx.doi.org/10.1016/j.healun.2019.02.004DOI Listing
April 2019
3 Reads

Evaluation of a lateral thoracotomy implant approach for a centrifugal-flow left ventricular assist device: The LATERAL clinical trial.

J Heart Lung Transplant 2019 Apr;38(4):344-351

Division of Cardiothoracic Surgery, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

Background: The HeartWare centrifugal-flow ventricular assist device system (HVAD) is a viable option for treatment of advanced heart failure. There is a growing trend toward the use of less invasive techniques in cardiac surgery, and the thoracotomy technique for HVAD implantation may provide benefits not available with conventional approaches.

Methods: The LATERAL trial is a multicenter, prospective, non-randomized, single-arm trial that utilized data from 144 patients enrolled in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database at 26 centers in the United States and Canada. Read More

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http://dx.doi.org/10.1016/j.healun.2019.02.002DOI Listing
April 2019
2 Reads

First human use of a wireless coplanar energy transfer coupled with a continuous-flow left ventricular assist device.

J Heart Lung Transplant 2019 Apr 5;38(4):339-343. Epub 2019 Feb 5.

Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. Electronic address:

The drive-line to power contemporary ventricular assist devices exiting the skin is associated with infection, and requires a holstered performance of the cardiac pump, which reduces overall quality of life. Attempts to eliminate the drive-line using transcutaneous energy transfer systems have been explored but have not succeeded in viable widespread application. The unique engineering of the coplanar energy transfer system is characterized by 2 large rings utilizing a coil-within-the-coil topology, ensuring robust resonance energy transfer while allowing for a substantial (>6 hours) unholstered circulatory support powered by an implantable battery source. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1316DOI Listing

Short-term results with transcatheter aortic valve replacement for treatment of left ventricular assist device patients with symptomatic aortic insufficiency.

J Heart Lung Transplant 2019 Mar 11. Epub 2019 Mar 11.

Piedmont Heart Institute, Atlanta, Georgia, USA.

Background: After 3years of continuous-flow left ventricular assist device (CF-LVAD) support, nearly a third of patients develop at least moderate aortic insufficiency (AI). Percutaneous occluder devices, surgical aortic valve replacement (SAVR), and urgent heart transplantation are available treatment options. Transcatheter aortic valve replacement (TAVR) has not been widely used for treating symptomatic AI in patients on LVAD support. Read More

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http://dx.doi.org/10.1016/j.healun.2019.03.001DOI Listing
March 2019
1 Read

Primary graft dysfunction: Worry less about organ quality and do more to improve candidate condition.

J Heart Lung Transplant 2019 Mar 11. Epub 2019 Mar 11.

Department of Pediatrics, Heart Institute, Children's Hospital Colorado, University of Colorado, Aurora, Colorado, USA. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2019.03.002DOI Listing

Dynamic flow responses to expiratory maneuvers in left ventricular assist device patients.

J Heart Lung Transplant 2019 Feb 27. Epub 2019 Feb 27.

Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.healun.2019.02.011DOI Listing
February 2019

Extended criteria donor lungs do not impact recipient outcomes in pediatric transplantation.

J Heart Lung Transplant 2019 Feb 27. Epub 2019 Feb 27.

Division of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; German Centre for Lung Research, BREATH site, Hannover, Germany. Electronic address:

Background: Pediatric lung transplantation remains the only curative treatment option for some end-stage lung diseases in childhood. Recipient numbers outnumber potential donor organs, and therefore a broader group of donor organs must be considered for pediatric lung transplantation. Herein we describe the outcome of utilizing extended criteria donor organs in pediatric lung transplantation. Read More

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http://dx.doi.org/10.1016/j.healun.2019.02.012DOI Listing
February 2019
1 Read

Elevated pre-transplant left ventricular end-diastolic pressure increases primary graft dysfunction risk in double lung transplant recipients.

J Heart Lung Transplant 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Background: Primary graft dysfunction (PGD) represents ischemia‒reperfusion injury in the lung allograft, and elevated left ventricular end-diastolic pressure (LVEDP) may contribute to capillary leak. We tested whether pre-transplant LVEDP or pulmonary capillary wedge pressure (mPCWP) are related to PGD risk. We hypothesized that elevated LVEDP and mPCWP would increase PGD risk. Read More

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http://dx.doi.org/10.1016/j.healun.2019.02.010DOI Listing
February 2019
1 Read

Prothrombotic activity of cytokine-activated endothelial cells and shear-activated platelets in the setting of ventricular assist device support.

J Heart Lung Transplant 2019 Feb 18. Epub 2019 Feb 18.

Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy; Advanced Heart Failure and Mechanical Circulatory Support Program, San Raffaele Scientific Institute, Milano, Italy; Università Vita Salute San Raffaele, Milano, Italy. Electronic address:

Background: We systematically analyzed the synergistic effect of: (i) cytokine-mediated inflammatory activation of endothelial cells (ECs) with and (ii) shear-mediated platelet activation (SMPA) as a potential contributory mechanism to intraventricular thrombus formation in the setting of left ventricular assist device (LVAD) support.

Methods: Intact and shear-activated human platelets were exposed to non-activated and cytokine-activated ECs. To modulate the level of LVAD-related shear activation, platelets were exposed to shear stress patterns of varying magnitude (30, 50, and 70 dynes/cm, 10 minutes) via a hemodynamic shearing device. Read More

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http://dx.doi.org/10.1016/j.healun.2019.02.009DOI Listing
February 2019
2 Reads
6.650 Impact Factor

Acid sphingomyelinase deficiency (Niemann‒Pick disease Type B) as an inflammatory disease.

J Heart Lung Transplant 2019 Feb 16. Epub 2019 Feb 16.

Service de Médecine Interne, Centre de Référence des Maladies Lysosomales, Hôpital de la Croix, 125 rue d'Avron, 75020 Paris, France.

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http://dx.doi.org/10.1016/j.healun.2019.02.008DOI Listing
February 2019

Risk of anastomotic dehiscence in patients with pulmonary fibrosis transplanted while receiving anti-fibrotics: Experience of the Australian Lung Transplant Collaborative.

J Heart Lung Transplant 2019 Feb 12. Epub 2019 Feb 12.

Queensland Lung Transplant Service, The Prince Charles Hospital, Chermside, Queensland, Australia; Faculty of Medicine, The University of Queensland, Queensland, Australia.

Background: The new anti-fibrotics pirfenidone and nintedanib are now in widespread use for idiopathic pulmonary fibrosis (IPF), but they may have an adverse impact on pathways involved in wound-healing. This study aimed to establish the safety of anti-fibrotic therapy in the peri-transplant period, particularly with regard to healing of the bronchial anastomosis.

Methods: In this work we assessed a retrospective cohort of patients who had undergone lung transplantation with a diagnosis of pulmonary fibrosis between January 2012 and December 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10532498193136
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http://dx.doi.org/10.1016/j.healun.2019.02.005DOI Listing
February 2019
7 Reads

The pleural mesothelium and transforming growth factor-β pathways in restrictive allograft syndrome: A pre-clinical investigation.

J Heart Lung Transplant 2019 Feb 6. Epub 2019 Feb 6.

Leuven Lung Transplant Group, Department of Chronic Diseases, Metabolism & Ageing, KU Leuven, Leuven, Belgium. Electronic address:

Background: Chronic lung allograft dysfunction (CLAD) hampers long-term survival after lung transplantation. Common fibrosis-related mechanisms in idiopathic pulmonary fibrosis and CLAD instigated the consideration of investigating the differential regulation of pleural mesothelium and transforming growth factor-β (TGF-β) in restrictive allograft syndrome (RAS).

Methods: TGF-β was assessed in bronchoalveolar lavage (BAL) fluid using enzyme-linked immunoassay and via immune staining of explant biopsies. Read More

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http://dx.doi.org/10.1016/j.healun.2019.02.001DOI Listing
February 2019
1 Read

An integrated molecular diagnostic report for heart transplant biopsies using an ensemble of diagnostic algorithms.

J Heart Lung Transplant 2019 Feb 6. Epub 2019 Feb 6.

Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Alberta, Canada; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Background: We previously reported a microarray-based diagnostic system for heart transplant endomyocardial biopsies (EMBs), using either 3-archetype (3AA) or 4-archetype (4AA) unsupervised algorithms to estimate rejection. In the present study we examined the stability of machine-learning algorithms in new biopsies, compared 3AA vs 4AA algorithms, assessed supervised binary classifiers trained on histologic or molecular diagnoses, created a report combining many scores into an ensemble of estimates, and examined possible automated sign-outs.

Methods: We studied 889 EMBs from 454 transplant recipients at 8 centers: the initial cohort (N = 331) and a new cohort (N = 558). Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1318DOI Listing
February 2019
3 Reads

Molecular assessment of rejection and injury in lung transplant biopsies.

J Heart Lung Transplant 2019 Feb 6. Epub 2019 Feb 6.

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Alberta Transplant Applied Genomics Center, Edmonton, Alberta, Canada. Electronic address:

Background: Improved understanding of lung transplant disease states is essential because failure rates are high, often due to chronic lung allograft dysfunction. However, histologic assessment of lung transplant transbronchial biopsies (TBBs) is difficult and often uninterpretable even with 10 pieces.

Methods: We prospectively studied whether microarray assessment of single TBB pieces could identify disease states and reduce the amount of tissue required for diagnosis. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1317DOI Listing
February 2019
4 Reads

Implications of declining donor offers with increased risk of disease transmission on waiting list survival in lung transplantation.

J Heart Lung Transplant 2019 Mar 21;38(3):295-305. Epub 2018 Dec 21.

Division of Cardiovascular and Thoracic Surgery.

Background: Donors with characteristics that may increase the likelihood of disease transmission with transplantation are noted as increased risk via Public Health Service criteria. This study aimed to establish the implications of declining an increased-risk donor (IRD) organ offer in lung transplantation.

Methods: Adult candidates waitlisted for isolated lung transplantation in the United States using the Organ Procurement and Transplantation Network /United Network of Organ Sharing registry from 2007 to 2017 were identified. Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.012DOI Listing
March 2019
6 Reads

Transplant outcomes for idiopathic pulmonary hypertension in children.

J Heart Lung Transplant 2019 Feb 5. Epub 2019 Feb 5.

Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.

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http://dx.doi.org/10.1016/j.healun.2019.01.1314DOI Listing
February 2019
1 Read

Timing of mechanically assisted circulatory support.

Authors:
Jacob Bergsland

J Heart Lung Transplant 2019 Apr 29;38(4):418-419. Epub 2019 Jan 29.

Intervention Center, Oslo University Hospital, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2019.01.1308DOI Listing

Quality of death after left ventricular assist device implantation: More questions than answers.

J Heart Lung Transplant 2019 Apr 25;38(4):382-384. Epub 2019 Jan 25.

Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.healun.2019.01.1307DOI Listing

Montelukast for chronic lung allograft dysfunction: Not quite the "Full Monty".

J Heart Lung Transplant 2019 Jan 30. Epub 2019 Jan 30.

Lung Transplant Unit, St. Vincent's Hospital, Sydney, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2019.01.1312DOI Listing
January 2019

Avoidance of Outflow Graft Extrinsic Compression in Polytetrafluoroethylene Reinforcements of the Bend Relief Component.

J Heart Lung Transplant 2019 Apr 29;38(4):474-475. Epub 2019 Jan 29.

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Germany; Department of Cardiothoracic Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.

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http://dx.doi.org/10.1016/j.healun.2019.01.1311DOI Listing

A comparison of low and standard anti-coagulation regimens in extracorporeal membrane oxygenation.

J Heart Lung Transplant 2019 Apr 31;38(4):433-439. Epub 2019 Jan 31.

Department of Surgery, George Washington University Medical Center, Washington, DC.

Background: Bleeding and need for blood products are major complications associated with extracorporeal membrane oxygenation (ECMO) use. This study evaluated bleeding complications with low and standard heparinization protocols in the maintenance of venoarterial (VA)-ECMO.

Methods: A retrospective comparison was performed of 2 methods of heparinization in a contemporaneous series of adult patients supported with VA-ECMO at Rush University Medical Center, between November 2011 and November 2016. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1313DOI Listing
April 2019
4 Reads

Blood pressure in a mechanically assisted circulation: "Heat, spirit, perfection".

J Heart Lung Transplant 2019 Apr 25;38(4):406-407. Epub 2019 Jan 25.

Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1016/j.healun.2019.01.1309DOI Listing

Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry.

J Heart Lung Transplant 2019 Apr 17;38(4):364-373. Epub 2019 Jan 17.

James and John Kirklin Institute for Research in Surgical Outcomes (KIRSO), University of Alabama, Birmingham, Alabama.

Background: Despite advances in device technology and treatment strategies, infection remains a major cause of adverse events (AEs) in mechanical circulatory support (MCS) patients. To characterize the epidemiology of MCS infection, we examined the type, location, and timing of infection in the International Society for Heart and Lung Transplantation Registry (ISHLT) for Mechanically Assisted Circulatory Support (IMACS) over 3 years, 2013 to 2015.

Methods: Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) definitions were used to categorize AE infections occurring in MCS patients within IMACS. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.007DOI Listing
April 2019
1 Read

Exercise cardiovascular magnetic resonance imaging allows differentiation of low-risk pulmonary arterial hypertension.

J Heart Lung Transplant 2019 Jan 25. Epub 2019 Jan 25.

Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address:

Background: Patients with pulmonary arterial hypertension (PAH) have a decreased ability to compensate for demands on increased cardiac output, such as during exercise. In this study we aimed to differentiate cardiac exercise responses in patients with PAH, stratified according to known measurements of disease severity.

Methods: Right and left ventricular end-diastolic volume and end-systolic volume, stroke volume (SV), and cardiac output were measured in 20 patients with PAH and a lower risk of mortality with 6-month intervals using cardiovascular magnetic resonance (CMR) imaging during rest and during ergometer exercise (totaling 44 scans). Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1305DOI Listing
January 2019
2 Reads

Incidence, predictors, and outcomes after severe primary graft dysfunction in pediatric heart transplant recipients.

J Heart Lung Transplant 2019 Jan 24. Epub 2019 Jan 24.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA; Department of Pediatrics. Electronic address:

Background: Previous reports of primary graft dysfunction (PGD) in pediatric heart transplant (HT) recipients are limited to descriptive series of children who required extracorporeal membrane oxygenation (ECMO) support shortly after HT. In this study we sought to determine the incidence, risk factors, and survival after severe PGD in pediatric HT recipients.

Methods: We identified all children <18 years old who underwent HT in the United States during 1996 to 2015 using the Organ Procurement and Transplant Network database and then identified those who developed severe PGD by linking patient variables to Extracorporeal Life Support Organization registry data. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1310DOI Listing
January 2019

Outcomes in cystic fibrosis lung transplant recipients infected with organisms labeled as pan-resistant: An ISHLT Registry‒based analysis.

J Heart Lung Transplant 2019 Jan 25. Epub 2019 Jan 25.

Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California, USA. Electronic address:

Background: The presence of pan-resistant organisms in patients with cystic fibrosis (CF) potentially impacts mortality after lung transplant (LT). In this study we aimed to study LT mortality in CF patients with and without pan-resistant infection.

Methods: The International Society for Heart and Lung Transplantation (ISHLT) Thoracic Transplant Registry was used to identify adults with CF, first-time, bilateral LT from 1991 to 2015. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.1306DOI Listing
January 2019
5 Reads

The evolving classification of chronic lung allograft dysfunction: Phenotypes and causes known and unknown.

J Heart Lung Transplant 2019 Jan 15. Epub 2019 Jan 15.

Pulmonary Division, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2019.01.008DOI Listing
January 2019

Pulmonary cuff dysfunction after lung transplant surgery: A systematic review of the evidence and analysis of its clinical implications.

J Heart Lung Transplant 2019 Jan 7. Epub 2019 Jan 7.

Department of Anesthesiology, The Ohio State University Wexner Medical Center. Electronic address:

Background: Pulmonary cuff dysfunction, either due to pulmonary vein obstruction, pulmonary vein stenosis, or pulmonary vein thrombosis, is an uncommon, yet serious complication after lung transplantation. Although there have been numerous reports of its occurrence, there is little consensus regarding the hemodynamic parameters associated with its presentation and diagnostic considerations. This systematic review summarizes the evidence surrounding pulmonary cuff dysfunction after lung transplantation surgery and empirically analyzes its implications. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.005DOI Listing
January 2019
3 Reads

Hydroxocobalamin treatment of refractory vasoplegia in patients with mechanical circulatory support.

J Heart Lung Transplant 2019 Apr 7;38(4):467-469. Epub 2019 Jan 7.

Department of Anesthesiology and Perioperative Medicine.

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http://dx.doi.org/10.1016/j.healun.2019.01.003DOI Listing

Infectious complications after heart transplantation in patients screened with gene expression profiling.

J Heart Lung Transplant 2019 Jan 7. Epub 2019 Jan 7.

Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Department of Medicine, Stanford University, Stanford, California, USA. Electronic address:

Background: The risk of infection after heart transplantation is highest within the first year and represents the leading cause of early mortality. In this cohort of patients enrolled in the Outcomes AlloMap Registry (OAR), we sought to describe infection episodes (IEp) resulting in hospitalization, in the early (<1 year) and late (≥1 year) post-transplant period and determine the impact of immunosuppression on incidence of infection.

Methods: The primary aim was to assess the incidence and nature of IEp. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.006DOI Listing
January 2019
1 Read

The revolutionary nature of pediatric continuous-flow miniaturized devices.

Authors:
Antonio Loforte

J Heart Lung Transplant 2019 Apr 9;38(4):394-395. Epub 2019 Jan 9.

Department of Cardiothoracic, Transplantation and Vascular Surgery, S. Orsola Hospital, Bologna University, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.11.016DOI Listing
April 2019
1 Read

ERRATUM.

Authors:

J Heart Lung Transplant 2019 Feb;38(2):233

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http://dx.doi.org/10.1016/j.healun.2018.11.012DOI Listing
February 2019

Use of an implantable wireless pulmonary pressure monitor during transition of therapy in pulmonary arterial hypertension.

J Heart Lung Transplant 2019 Feb 24;38(2):227-230. Epub 2018 Nov 24.

Cardiovascular Institute, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.healun.2018.11.011DOI Listing
February 2019

Development of a transplant injection device for optimal distribution and retention of human induced pluripotent stem cell‒derived cardiomyocytes.

J Heart Lung Transplant 2019 Feb 15;38(2):203-214. Epub 2018 Nov 15.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Background: Induced pluripotent stem cell (iPSC)‒based regenerative therapy is a promising strategy for cardiovascular disease treatment; however, the method is limited by the myocardial retention of grafted iPSCs. Thus, an injection protocol that efficiently introduces and retains human iPSC-derived cardiomyocytes (hiPSC-CMs) within the myocardium is urgently needed. The objective of the present study was to develop a method to improve the retention of hiPSCs in the myocardium for cardiac therapy. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.002DOI Listing
February 2019
3 Reads

Sizing it up in heart transplantation: Time to change the guidelines?

J Heart Lung Transplant 2019 Feb 14;38(2):133-135. Epub 2018 Dec 14.

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.12.004DOI Listing
February 2019
2 Reads

Diffusion capacity of the lung-a disease biomarker linking ventilation and circulation.

J Heart Lung Transplant 2019 Feb 1;38(2):130-132. Epub 2018 Dec 1.

Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2018.11.008DOI Listing
February 2019

The Society of Thoracic Surgeons Intermacs database annual report: Evolving indications, outcomes, and scientific partnerships.

J Heart Lung Transplant 2019 Feb;38(2):114-126

Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

Background: The Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs), a joint effort among the National Heart, Lung, and Blood Institute, the Food and Drug Administration, the Centers for Medicare and Medicaid Services, and others, was established in 2005 at the University of Alabama at Birmingham. The registry examined clinical outcomes and quality-of-life metrics of patients who received an Food and Drug Administration-approved durable mechanical circulatory support (MCS) device to treat advanced heart failure. On January 1, 2018, the Intermacs Database became part of The Society of Thoracic Surgeons National Database, providing additional resources for quality assessment and improvement and scientific advancement. Read More

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http://dx.doi.org/10.1016/j.healun.2018.11.013DOI Listing
February 2019
4 Reads

Azithromycin and early allograft function after lung transplantation: A randomized, controlled trial.

J Heart Lung Transplant 2019 Mar 14;38(3):252-259. Epub 2018 Dec 14.

Lung Transplant Unit, Department of Chronic Diseases, Metabolism & Ageing. Electronic address:

Background: Chronic lung allograft dysfunction (CLAD) is the single most important factor limiting long-term survival after lung transplantation (LTx). Azithromycin has been shown to improve CLAD-free and long-term survival, yet the possible impact on early lung allograft function is unclear.

Methods: A prospective, randomized, double-blind, placebo-controlled trial of pre-transplant and prompt post-transplant azithromycin treatment was performed at the University Hospitals Leuven. Read More

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http://dx.doi.org/10.1016/j.healun.2018.12.006DOI Listing
March 2019
2 Reads

Thrombotic events with proliferation signal inhibitor‒based immunosuppression in cardiac transplantation.

J Heart Lung Transplant 2019 Jan 7. Epub 2019 Jan 7.

WVU Medicine, Morgantown, West Virginia, USA.

Background: Some literature exists potentially linking proliferation signal inhibitors (PSIs) to venous thromboembolism (VTE). We sought to determine the impact of PSIs on development of VTE in heart transplant (HT) patients while controlling for other risk factors.

Methods: The incidence and predisposing factors of VTE were analyzed in this retrospective review of patients >18 years who underwent HT January 2000 to October 2016. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.004DOI Listing
January 2019
2 Reads

Stiff left atrial syndrome and heart transplantation.

J Heart Lung Transplant 2018 Dec 28. Epub 2018 Dec 28.

Heart Transplant Unit, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.healun.2018.12.017DOI Listing
December 2018
3 Reads