27,704,965 results match your criteria Journal of Health and Productivity [Journal]

  • Page 1 of 554100

Long-term effectiveness of cinacalcet in non-dialysis patients with chronic kidney disease and secondary hyperparathyroidism.

Kidney Res Clin Pract 2019 Apr 25;38(1). Epub 2019 Apr 25.

Pharmacy Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Background: Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Cinacalcet use is controversial in non-dialysis patients.

Methods: This retrospective observational study recruited patients receiving cinacalcet (off-label use) in 2010 and 2011. Read More

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http://dx.doi.org/10.23876/j.krcp.18.0088DOI Listing

Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma with Late Recurrence.

J Pathol Transl Med 2019 Apr 25. Epub 2019 Apr 25.

Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4132/jptm.2019.04.02DOI Listing

Compound-specific stable carbon isotope analysis of hexabromocyclododecane diastereoisomers using gas chromatography-isotope ratio mass spectrometry.

Rapid Commun Mass Spectrom 2019 Apr 25. Epub 2019 Apr 25.

State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment Protection and Resource Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China.

Rationale: Compound-specific stable isotope analysis (CSIA) is a powerful tool for the source apportionment and characterization of environmental transformation processes, especially for new emerging contaminants. In this study, we have developed an effective method for determination of the stable carbon isotope ratios of hexabromocyclododecane diastereoisomers.

Methods: Three diastereoisomers of hexabromocyclododecane (HBCD), α-, β-, and γ-HBCD, were separated on a preparative high-performance liquid chromatography (HPLC) system. Read More

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http://dx.doi.org/10.1002/rcm.8472DOI Listing

Depression and Inflammation among Epidermal Growth Factor Receptor (EGFR) Mutant Non-Small Cell Lung Cancer Patients.

Psychooncology 2019 Apr 25. Epub 2019 Apr 25.

Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY.

Objectives: Depression is highly prevalent in Non-Small Cell Lung cancer (NSCLC) and is associated with elevated inflammation. However, certain subtypes of driver mutation associated NSCLC such as Epidermal Growth Factor Receptor (EGFR) mutated NSCLC may be associated with less depression given the differences in their underlying biology and disease trajectories. Biological variables such as inflammation, measured by C-reactive protein (CRP), may provide insight into depression variability in EGFR mutant NSCLC. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pon.5097
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http://dx.doi.org/10.1002/pon.5097DOI Listing
April 2019
1 Read

Surgical and oncological outcomes after ultrasound-guided robotic liver resections for malignant tumor. Analysis of a prospective database.

Int J Med Robot 2019 Apr 25:e2002. Epub 2019 Apr 25.

Division of Oncological and Robotic General Surgery, Careggi University Hospital, Florence, Italy.

Aim: Robotic surgery is thought to have a role in widening the application of minimally invasive liver surgery. Nonetheless, data concerning surgical results for liver malignancies are presently still lacking. We aimed to evaluate the surgical and oncological outcomes of ultrasound guided robotic liver resections for hepatic malignancies. Read More

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http://dx.doi.org/10.1002/rcs.2002DOI Listing

The double burden of food insecurity and obesity among Latino youth: Understanding the role of generational status.

Pediatr Obes 2019 Apr 25:e12525. Epub 2019 Apr 25.

Department of Public Health Education, University of North Carolina, Greenboro, NC, USA.

Background: Obesity is linked to food insecurity and generational status; however, little is known about how both impact obesity risk among Latino youth.

Objective: To investigate the joint effect of generational status and food insecurity on obesity prevalence among Latino youth.

Methods: We pooled data from the 2011 to 2017 waves of the National Health Interview Survey to derive a sample Latino youth aged 12 to 17 (N = 7532). Read More

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http://dx.doi.org/10.1111/ijpo.12525DOI Listing

Quantitative analysis of the yeast pheromone pathway.

Yeast 2019 Apr 25. Epub 2019 Apr 25.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

The pheromone response pathway of the yeast S. cerevisiae is a well-established model for the study of G proteins and mitogen-activated protein kinase (MAPK) cascades. Our longstanding ability to combine sophisticated genetic approaches with established functional assays has provided a thorough understanding of signaling mechanisms and regulation. Read More

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http://dx.doi.org/10.1002/yea.3395DOI Listing
April 2019
1 Read
1.634 Impact Factor

[French comment on article Risk of cancer in 10 - 19mm endoscopically detected colorectal lesions].

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Endoscopy 2019 May 25;51(5):505-506. Epub 2019 Apr 25.

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http://dx.doi.org/10.1055/a-0883-0160DOI Listing

SPED.live 2019.

Endoscopy 2019 May 25;51(5):502-503. Epub 2019 Apr 25.

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http://dx.doi.org/10.1055/a-0863-1005DOI Listing

Reply to Jagtap et al.

Endoscopy 2019 May 25;51(5):496. Epub 2019 Apr 25.

Department of Gastroenterology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1055/a-0841-9628DOI Listing

Revision surgery after endoscopic sutured gastroplasty.

Endoscopy 2019 May 25;51(5):495. Epub 2019 Apr 25.

Asian Institute of Gastroenterology, Hyderabad, India.

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http://dx.doi.org/10.1055/a-0826-4606DOI Listing

Polyp cancers: size matters!

Authors:
Pradeep Bhandari

Endoscopy 2019 May 25;51(5):407-408. Epub 2019 Apr 25.

Gastroenterology, Queen Alexandra Hospital, Portsmouth, United Kingdom.

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http://dx.doi.org/10.1055/a-0871-2404DOI Listing

Unplanned but proven obsolescence for 19 G endoscopic ultrasound needles.

Authors:
Pierre H Deprez

Endoscopy 2019 May 25;51(5):405-406. Epub 2019 Apr 25.

Department of Hepatogastroenterology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1055/a-0836-2596DOI Listing

Endoscopic examination of the papilla: to cap or swap the scope?

Endoscopy 2019 May 25;51(5):403-404. Epub 2019 Apr 25.

Department of Gastroenterology, Erasme University Hospital, Brussels, Belgium.

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http://dx.doi.org/10.1055/a-0831-2571DOI Listing

Will the steerable capsule replace upper endoscopy in the future?

Authors:
Martin Keuchel

Endoscopy 2019 May 25;51(5):401-402. Epub 2019 Apr 25.

Department of Internal Medicine, Bethesda Hospital Bergedorf, Academic Teaching Hospital of the University of Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1055/a-0808-3341DOI Listing

Small-bowel endoscopy.

Endoscopy 2019 May 25;51(5):399-400. Epub 2019 Apr 25.

OUS-Rikshospitalet University Hospital, GI endoscopy, Oslo, Norway.

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http://dx.doi.org/10.1055/a-0879-1823DOI Listing

Video Comment on Jin-Seok Park et al.

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Endoscopy 2019 May 25;51(5):v12. Epub 2019 Apr 25.

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http://dx.doi.org/10.1055/a-0853-3692DOI Listing

Video Comment on Alberto Larghi et al.

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Endoscopy 2019 May 25;51(5):v11. Epub 2019 Apr 25.

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http://dx.doi.org/10.1055/a-0865-3148DOI Listing

Video Comment on Xin Shi et al.

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Endoscopy 2019 May 25;51(5):v10. Epub 2019 Apr 25.

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http://dx.doi.org/10.1055/a-0806-2642DOI Listing

Video Comment on Mohamed Abdelhafez et al.

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Endoscopy 2019 May 25;51(5):v9. Epub 2019 Apr 25.

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http://dx.doi.org/10.1055/a-0806-2596DOI Listing

Video Comment on Hey-Long Ching et al.

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Endoscopy 2019 May 25;51(5):v8. Epub 2019 Apr 25.

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http://dx.doi.org/10.1055/a-0806-2674DOI Listing

Outcomes after Split Abdominal Wall Muscle Flap Repair for Large Congenital Diaphragmatic Hernias.

Eur J Pediatr Surg 2019 Apr 25. Epub 2019 Apr 25.

Department of Pediatric Surgery, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

Background:  Repair of large congenital diaphragmatic hernias (CDHs) is challenging. As primary repair is not always feasible, patches are commonly used. An alternative treatment is split abdominal wall muscle flap repair, which uses vascularized autologous tissue. Read More

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http://dx.doi.org/10.1055/s-0039-1687867DOI Listing

Low Plasma Sodium Concentration Predicts Perforated Acute Appendicitis in Children: A Prospective Diagnostic Accuracy Study.

Eur J Pediatr Surg 2019 Apr 25. Epub 2019 Apr 25.

Department of Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska University Hospital Solna, Stockholm, Sweden.

Background:  Early differentiation between perforated and nonperforated acute appendicitis (AA) in children is of major benefit for the selection of proper treatment. Based on pilot study data, we hypothesized that plasma sodium concentration at hospital admission is a diagnostic marker for perforation in children with AA.

Materials And Methods:  This was a prospective diagnostic accuracy study, including previously healthy children, 1 to 14 years of age, with AA. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1687870
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http://dx.doi.org/10.1055/s-0039-1687870DOI Listing
April 2019
1 Read

An Open Science Approach to Artificial Intelligence in Healthcare.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Kyoto University, Japan.

Objectives: Artificial Intelligence (AI) offers significant potential for improving healthcare. This paper discusses how an "open science" approach to AI tool development, data sharing, education, and research can support the clinical adoption of AI systems.

Method: In response to the call for participation for the 2019 International Medical Informatics Association (IMIA) Yearbook theme issue on AI in healthcare, the IMIA Open Source Working Group conducted a rapid review of recent literature relating to open science and AI in healthcare and discussed how an open science approach could help overcome concerns about the adoption of new AI technology in healthcare settings. Read More

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http://dx.doi.org/10.1055/s-0039-1677898DOI Listing

Artificial Intelligence in Clinical Decision Support: Challenges for Evaluating AI and Practical Implications.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Macquarie University, Australian Institute of Health Innovation, Sydney, Australia.

Objectives: This paper draws attention to: i) key considerations for evaluating artificial intelligence (AI) enabled clinical decision support; and ii) challenges and practical implications of AI design, development, selection, use, and ongoing surveillance.

Method: A narrative review of existing research and evaluation approaches along with expert perspectives drawn from the International Medical Informatics Association (IMIA) Working Group on Technology Assessment and Quality Development in Health Informatics and the European Federation for Medical Informatics (EFMI) Working Group for Assessment of Health Information Systems.

Results: There is a rich history and tradition of evaluating AI in healthcare. Read More

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http://dx.doi.org/10.1055/s-0039-1677903DOI Listing

Artificial Intelligence in Primary Health Care: Perceptions, Issues, and Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK.

Background: Artificial intelligence (AI) is heralded as an approach that might augment or substitute for the limited processing power of the human brain of primary health care (PHC) professionals. However, there are concerns that AI-mediated decisions may be hard to validate and challenge, or may result in rogue decisions.

Objective: To form consensus about perceptions, issues, and challenges of AI in primary care. Read More

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http://dx.doi.org/10.1055/s-0039-1677901DOI Listing

Role of Artificial Intelligence within the Telehealth Domain.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

IBM Research, Brazil.

Objectives: This paper provides a discussion about the potential scope of applicability of Artificial Intelligence methods within the telehealth domain. These methods are focussed on clinical needs and provide some insight to current directions, based on reports of recent advances.

Methods: Examples of telehealth innovations involving Artificial Intelligence to support or supplement remote health care delivery were identified from recent literature by the authors, on the basis of expert knowledge. Read More

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http://dx.doi.org/10.1055/s-0039-1677897DOI Listing

Artificial Intelligence for Participatory Health: Applications, Impact, and Future Implications.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Swinburne University of Technology, and University of Melbourne, Australia.

Objective: Artificial intelligence (AI) provides people and professionals working in the field of participatory health informatics an opportunity to derive robust insights from a variety of online sources. The objective of this paper is to identify current state of the art and application areas of AI in the context of participatory health.

Methods: A search was conducted across seven databases (PubMed, Embase, CINAHL, PsychInfo, ACM Digital Library, IEEExplore, and SCOPUS), covering articles published since 2013. Read More

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http://dx.doi.org/10.1055/s-0039-1677902DOI Listing

The Interplay of Knowledge Representation with Various Fields of Artificial Intelligence in Medicine.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Associate Professor, Department of Medical Informatics, Academic Medical Center - University of Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Introduction: Artificial intelligence (AI) is widespread in many areas, including medicine. However, it is unclear what exactly AI encompasses. This paper aims to provide an improved understanding of medical AI and its constituent fields, and their interplay with knowledge representation (KR). Read More

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http://dx.doi.org/10.1055/s-0039-1677899DOI Listing

Serious Games in Health Professions Education: Review of Trends and Learning Efficacy.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Games for Health Innovations Centre, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Objectives: To provide an overview of research trends and a review regarding the learning efficacy of serious games for health professions education taking into account short-term learning outcomes.

Methods: For the review of research trends, we performed the search on Web of Science from 1996 until the present. For the scoping review on learning efficacy, ERIC, Education Source, PsychINFO, Global Health, CINAHL, Web Of Science, and Medline were searched. Read More

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http://dx.doi.org/10.1055/s-0039-1677904DOI Listing

The Price of Artificial Intelligence.

Authors:
Enrico Coiera

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia.

Introduction: Whilst general artificial intelligence (AI) is yet to appear, today's narrow AI is already good enough to transform much of healthcare over the next two decades.

Objective: There is much discussion of the potential benefits of AI in healthcare and this paper reviews the cost that may need to be paid for these benefits, including changes in the way healthcare is practiced, patients are engaged, medical records are created, and work is reimbursed.

Results: Whilst AI will be applied to classic pattern recognition tasks like diagnosis or treatment recommendation, it is likely to be as disruptive to clinical work as it is to care delivery. Read More

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http://dx.doi.org/10.1055/s-0039-1677892DOI Listing

Artificial Intelligence in Medicine: Weighing the Accomplishments, Hype, and Promise.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Biomedical Informatics, Columbia University.

Introduction: Artificial Intelligence in Medicine (AIM) research is now 50 years old, having made great progress that has tracked the corresponding evolution of computer science, hardware technology, communications, and biomedicine. Characterized as being in its "adolescence" at an international meeting in 1991, and as "coming of age" at another meeting in 2007, the AIM field is now more visible and influential than ever before, paralleling the enthusiasm and accomplishments of artificial intelligence (AI) more generally.

Objectives: This article summarizes some of that AIM history, providing an update on the status of the field as it enters its second half-century. Read More

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http://dx.doi.org/10.1055/s-0039-1677891DOI Listing

Beginnings of Artificial Intelligence in Medicine (AIM): Computational Artifice Assisting Scientific Inquiry and Clinical Art - with Reflections on Present AIM Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Computer Science, Rutgers University, USA.

Background: The rise of biomedical expert heuristic knowledge-based approaches for computational modeling and problem solving, for scientific inquiry and medical decision-making, and for consultation in the 1970's led to a major change in the paradigm that affected all of artificial intelligence (AI) research. Since then, AI has evolved, surviving several "winters", as it has oscillated between relying on expensive and hard-to-validate knowledge-based approaches, and the alternative of using machine learning methods for inferring classification rules from labelled datasets. In the past couple of decades, we are seeing a gradual but progressive intertwining of the two. Read More

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http://dx.doi.org/10.1055/s-0039-1677895DOI Listing

On the 80th Birthday of Jan van Bemmel.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Dept. of Medical informatics, Erasmus University, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1055/s-0039-1677893DOI Listing

Assessment of the Relationship Between Serum High Molecular Weight Adiponectin Hormone Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome.

Horm Metab Res 2019 Apr 25;51(4):261-266. Epub 2019 Apr 25.

VKV American Hospital, Women's Healthcare Centre, Istanbul, Turkey.

The purpose of this study was to assess the rate of insulin resistance (IR) and the relationship between IR and high-molecular weight adiponectin (HMWA) in patients with polycystic ovary syndrome (PCOS). A cross sectional study involving 43 women with PCOS and 39 normal women was carried out over a period of nine months. Fasting glucose and insulin levels, lipid parameters and androgen levels were measured in all serum samples. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0867-0886
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http://dx.doi.org/10.1055/a-0867-0886DOI Listing
April 2019
2 Reads

Characterization of a Novel POU1F1 Mutation Identified on Screening 160 Growth Hormone Deficiency Patients.

Horm Metab Res 2019 Apr 25;51(4):248-255. Epub 2019 Apr 25.

Laboratory of Cyto-Molecular Genetics, Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

The objective of the study is the functional characterization of a novel c.605delC mutation in combined pituitary hormone deficiency (CPHD) and to report the clinical and genetic details of 160 growth hormone deficiency patients. Screening of , , , , and genes by Sanger sequencing was carried out in 160 trios and 100 controls followed by characterization of the c. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0867-1026
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http://dx.doi.org/10.1055/a-0867-1026DOI Listing
April 2019
1 Read

Serum Prostate-Specific Antigen Level in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.

Horm Metab Res 2019 Apr 25;51(4):230-242. Epub 2019 Apr 25.

Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

We undertook a comprehensive search of all published original articles evaluating the diagnostic value of prostate-specific antigen (PSA) for the detection of polycystic ovary syndrome (PCOS). Finally, 25 studies with a total of 1865 participants (1104 cases and 761 controls) met the inclusion criteria. Mean serum PSA levels were significantly higher in PCOS women compared to healthy women [Standardized mean difference (SMD)=1. Read More

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http://dx.doi.org/10.1055/a-0863-5779DOI Listing

Visfatin Level and The Risk of Hypertension and Cerebrovascular Accident: A Systematic Review and Meta-Analysis.

Horm Metab Res 2019 Apr 25;51(4):220-229. Epub 2019 Apr 25.

Department of Cardiology, Huazhong University of Science and Technology, Wuhan, China.

High blood pressure is related with increased cerebrovascular accident. High visfatin / NAMPT(nicotinamide phosphoribosyltransferase) plasma levels may promote vascular inflammation and atherosclerotic plaque destabilization and have been evaluated as a marker for identifying stages of essential hypertension. However, its role in the pathogenesis of hypertension and cerebrovascular accident (CVA) is still uncertain. Read More

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http://dx.doi.org/10.1055/a-0867-1333DOI Listing

Social Network Structure in Young Stroke Survivors with Aphasia: A Case Series Report.

Semin Speech Lang 2019 Apr 25. Epub 2019 Apr 25.

Communication Equity and Outcomes Laboratory, College of Allied Health Sciences East Carolina University, Greenville, North Carolina.

The aim of this study was to profile the social networks of young adult stroke survivors with aphasia. A case series approach using four persons with aphasia (PWA) younger than 50 years was utilized. Semistructured interviews were completed with the PWA and their primary caregiver/family to explore the most salient relationships in the PWA's social network. Read More

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http://dx.doi.org/10.1055/s-0039-1688695DOI Listing

Effectiveness of Compressive External Bracing in Patients with Flexible Pectus Carinatum Deformity: A Review.

Thorac Cardiovasc Surg 2019 Apr 25. Epub 2019 Apr 25.

Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.

There has been a growing interest in the nonoperative treatment of chest wall deformities over the last few decades; with the advent of external compressive orthotics, similar outcomes have been reported compared with surgical intervention. There have been fewer major complications reported with dynamic compression bracing on the chest wall; however, the Achilles heel of this approach still lies with treatment tolerability and compliance. A Medline literature search was undertaken to evaluate the evidence concerning the techniques, modifications, and outcomes associated with external compressive bracing in the setting of pectus carinatum. Read More

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http://dx.doi.org/10.1055/s-0039-1687824DOI Listing

Microplegia versus Cardioplexol® in Coronary Artery Bypass Surgery with Minimal Extracorporeal Circulation: Comparison of Two Cardioplegia Concepts.

Thorac Cardiovasc Surg 2019 Apr 25. Epub 2019 Apr 25.

Department of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland.

Background:  The aim of this study is to compare the combined use of the Myocardial Protection System and our microplegia (Basel Microplegia Protocol) with Cardioplexol in coronary artery bypass grafting using the minimal extracorporeal circulation.

Methods:  The analysis focused on propensity score matched pairs of patients in whom microplegia or Cardioplexol was used. Primary efficacy endpoints were highsensitivity cardiac troponin-T on postoperative day 1 and peak values during hospitalization. Read More

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http://dx.doi.org/10.1055/s-0039-1687843DOI Listing

Head Biometry in Fetuses with Isolated Congenital Heart Disease.

Ultraschall Med 2019 Apr 25. Epub 2019 Apr 25.

Department of Obstetrics and Gynecology, Division of Prenatal Medicine, University-Hospital UKGM, Justus-Liebig-University, Giessen, Germany.

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http://dx.doi.org/10.1055/a-0893-7484DOI Listing

Optic Nerve Lipidomics Reveal Impaired Glucosylsphingosine Lipids Pathway in Glaucoma.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1789-1798

Department of Ophthalmology & Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States.

Purpose: To determine major differences in lipid profile between human control and glaucomatous optic nerve. To assess major enzymes in lipid pathway if aberration is revealed for a lipid class by profiling.

Methods: Optic nerve (ON) samples were obtained from human cadaveric donors [control (n = 11) and primary open-angle glaucoma (POAG; n = 12)]; the lipids were extracted using Bligh and Dyer methods. Read More

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http://dx.doi.org/10.1167/iovs.18-25802DOI Listing

Effect of αvβ3 Integrin Expression and Activity on Intraocular Pressure.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1776-1788

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States.

Purpose: To determine the effects of αvβ3 integrin expression and activation on intraocular pressure (IOP).

Methods: Cre+/-β3flox/flox mice were treated with topical tamoxifen eye drops for 5 days to activate Cre and excise the β3 integrin gene from the anterior segment. IOP was measured weekly for 11 weeks using rebound tonometry. Read More

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http://dx.doi.org/10.1167/iovs.18-26038DOI Listing

Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1734-1747

Department of Ophthalmology, University of California, San Francisco, California, United States.

Purpose: Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases involved in wound healing processes, including neovascularization and fibrosis. We assessed MMP protein expression levels in diseased corneas of patients requiring penetrating and deep anterior lamellar keratoplasty. The purpose of this study was to test the hypothesis that upregulation of MMPs in diseased corneas is positively associated with clinical levels of corneal neovascularization and fibrosis. Read More

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http://dx.doi.org/10.1167/iovs.18-25961DOI Listing

How to treat esophageal neuroendocrine carcinoma with proper stratification?

Authors:
Han-Yu Deng

Dis Esophagus 2019 Apr 25. Epub 2019 Apr 25.

Lung Cancer Center, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1093/dote/doz035DOI Listing

The relationship between initial threshold, learning, and generalization in perceptual learning.

J Vis 2019 Apr;19(4):28

Department of Cognitive Science, Central European University, Budapest, Hungary.

We investigated the origin of two previously reported general rules of perceptual learning. First, the initial discrimination thresholds and the amount of learning were found to be related through a Weber-like law. Second, increased training length negatively influenced the observer's ability to generalize the obtained knowledge to a new context. Read More

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http://dx.doi.org/10.1167/19.4.28DOI Listing
  • Page 1 of 554100