373,947 results match your criteria Journal of Health Services Research & Policy[Journal]


[Effective prevention and control of myopia in children and adolescents].

Authors:
J Qu F Lyu L D Xu

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):81-85

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Engineering Research Center For Myopia Control and Management, Ministry of Education, Wenzhou 325000, China.

Myopia prevention and control is an important health issue related to children and adolescents, general public physical fitness and national defense security. In 2018, General Secretary Xi Jinping gave instructions on students' myopia. Ministry of Education and other seven ministries and commissions issued the Implementation Plan of the Myopia Prevention and Control for Children and Adolescents. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.001DOI Listing
February 2019

Patterns of high-risk prescribing and other factors in relation to receipt of a home medicines review: a prospective cohort investigation among adults aged 45 years and over in Australia.

BMJ Open 2019 Feb 15;9(2):e027305. Epub 2019 Feb 15.

Research School of Population Health, Australian National University, Canberra, Sydney, Australia.

Objectives: To quantify the relationship between home medicines review (HMR) receipt in older adults and sociodemographic, medication-related and health factors.

Design: Prospective cohort analysis.

Settings, Participants, Measurements: Questionnaire data from a population-based cohort study of individuals aged ≥45 years, Sydney, Australia were linked with primary healthcare data, medication and hospitalisation data, to ascertain factors associated with HMR receipt during the period July 2009-June 2014. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027305DOI Listing
February 2019

Defining compassion in the digital health age: protocol for a scoping review.

BMJ Open 2019 Feb 15;9(2):e026338. Epub 2019 Feb 15.

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Introduction: The notion of compassion and compassionate care is playing an increasingly important role in health professional education and in the delivery of high-quality healthcare. Digital contexts, however, are not considered in the conceptualisation of compassionate care, nor is there guidance on how compassionate care is to be exercised while using digital health technologies. The widespread diffusion of digital health technologies provides new contexts for compassionate care, with both opportunities for new forms and instantiations of compassion as well as new challenges. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026338DOI Listing
February 2019

Paramedics' experiences of administering fascia iliaca compartment block to patients in South Wales with suspected hip fracture at the scene of injury: results of focus groups.

BMJ Open 2019 Feb 15;9(2):e026073. Epub 2019 Feb 15.

Medical School, Swansea University, Swansea, UK.

Objectives: To explore paramedics' experience of delivering fascia iliaca compartment block FICB) to patients with suspected hip fracture at the scene of injury.

Design: Focus groups within a randomised controlled trial.

Setting: Paramedics based at ambulance stations in the catchment area of one Emergency Department in South Wales, recruited and trained in a feasibility study about an alternative to routine prehospital pain management for patients with suspected hip fracture. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026073DOI Listing
February 2019

Frailty in the context of rehabilitation interventions for adults: protocol for a scoping review.

BMJ Open 2019 Feb 15;9(2):e024838. Epub 2019 Feb 15.

Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.

Introduction: Although a growing number of frail adults can benefit from rehabilitation services, few are included in rehabilitation services, and reasons for their exclusion are not well understood. To inform research directions in rehabilitation for all adults (aged 18 years and older), we will conduct a scoping review to describe (1) the characteristics of frail adult individuals included in rehabilitation interventions (eg, age range, inclusion and exclusion criteria that are applied), (2) the type of rehabilitation interventions that are used for individuals who are considered frail and (3) the commonly reported outcome measures used for these rehabilitation interventions.

Methods: This scoping review will be guided by Arksey and O'Malley's methodological framework. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024838DOI Listing
February 2019

Therapist-guided and parent-guided internet-delivered behaviour therapy for paediatric Tourette's disorder: a pilot randomised controlled trial with long-term follow-up.

BMJ Open 2019 Feb 15;9(2):e024685. Epub 2019 Feb 15.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Objective: Behaviour therapy (BT) for Tourette's disorder (TD) and persistent (chronic) motor or vocal tic disorder (PTD) is rarely available. We evaluated the feasibility of adapting two existing BT protocols for TD/PTD (habit reversal training (HRT) and exposure and response prevention (ERP)) into a therapist-guided and parent-guided online self-help format.

Design: A pilot, single-blind, parallel group randomised controlled trial. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024685DOI Listing
February 2019

Conversion of other opioids to methadone: a retrospective comparison of two methods.

BMJ Support Palliat Care 2019 Feb 16. Epub 2019 Feb 16.

Department of Supportive and Palliative Care, Mater Health Services, Brisbane, Queensland, Australia

Context: A rapid method of methadone conversion known as the Perth Protocol is commonly used in Australian palliative care units. There has been no follow-up or validation of this method and no comparison between different methods of conversion.

Objectives: The primary objective of this study was to test the hypothesis that the achieved doses of methadone are independent of the conversion method (rapid vs slower). Read More

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http://dx.doi.org/10.1136/bmjspcare-2018-001645DOI Listing
February 2019

NT-pro-BNP correlates with disease severity and predicts outcome in cerebral haemorrhage patients: Cohort study.

J Neurol Sci 2019 Feb 8;399:51-56. Epub 2019 Feb 8.

Internal Medicine Department, São João Hospital Centre, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; Stroke Unit, São João Hospital Centre, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal.

Background: Intracerebral haemorrhage (ICH) is a devastating condition, with more than half of patients dying or becoming dependent after such an event. Natriuretic peptides, frequently used in the management of heart failure, have been shown to correlate with disease severity and prognosis in brain disorders. The aim of this study was to test the hypothesis that NT-pro-BNP correlates with disease severity and is an independent prognostic marker for non-traumatic ICH patients. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.014DOI Listing
February 2019

Risk assessment scales to predict risk of hospital treated repeat self-harm: A cost-effectiveness modelling analysis.

J Affect Disord 2019 Feb 11;249:208-215. Epub 2019 Feb 11.

Centre for Mental Health and Safety and Greater Manchester Patient Safety Translational Research Centre, United Kingdom; Centre for Mental Health and Safety, University of Manchester, Jean McFarlane Building Oxford Road, Manchester M13 9PL, United Kingdom; Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom.

Background: Risk scales are used widely for assessing individuals presenting to Emergency Departments (EDs) following self-harm. There is growing evidence that risk scales have limited clinical utility in identifying episodes at highest risk of repeat self-harm. However, their cost-effectiveness in terms of treatment allocation and subsequent repeat self-harm is unknown. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.036DOI Listing
February 2019

Sex differences in the association between thyroid-stimulating hormone levels and depressive symptoms among the general population with normal free T4 levels.

J Affect Disord 2019 Feb 10;249:151-158. Epub 2019 Feb 10.

Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Overt and subclinical thyroid dysfunction has been reported to be related to depression. Thyroid diseases have been known to occur more frequently in women. However, scarce data are available on effects and sex differences of changes in thyroid-stimulating hormone (TSH) levels, with a normal range of thyroid hormones, on depression. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.027DOI Listing
February 2019

Spiritual struggles and mental health outcomes in a spiritually integrated inpatient program.

J Affect Disord 2019 Feb 6;249:127-135. Epub 2019 Feb 6.

Pine Rest Christian Mental Health Services, Grand Rapids, MI, United States.

Background: Persons contending with serious mental health difficulties often experience struggles with religious faith and/or spirituality that may also demand clinical attention. However, research has not examined the relative importance of specific forms of spiritual struggles in mental health status or treatment outcomes of psychiatric patients.

Methods: Focusing on 217 adults who completed a spiritually integrated inpatient program, this study examined (1) which struggles in Exline et al. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.012DOI Listing
February 2019

Health-related quality of life and psychological wellbeing of children with Specific Learning Disorders and their mothers.

Res Dev Disabil 2019 Feb 14;87:43-53. Epub 2019 Feb 14.

Department of Psychology, University of Bologna, Piazza Aldo Moro, 90, I-47521 Cesena (FC), Italy. Electronic address:

Background: Literature suggests that Specific Learning Disorders (SpLD) can cause impairment of Health-Related Quality of Life (HRQoL) and psychological well-being of children, and that this condition potentially affects parents' quality of life and well-being too.

Aims: This study aims first to explore HRQoL and psychological well-being among children with SpLD and second among mothers of children with SpLD.

Methods And Procedures: Thirty children aged 8-14 years diagnosed as having SpLD and their mothers completed a battery of scales to assess children's HRQoL and psychological well-being. Read More

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http://dx.doi.org/10.1016/j.ridd.2019.02.003DOI Listing
February 2019

Clustered risk: An ecological understanding of sexual activity among adolescent boys and girls in two urban slums in Monrovia, Liberia.

Soc Sci Med 2019 Feb 8;224:106-115. Epub 2019 Feb 8.

Department of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, 677 Huntington Avenue, Boston, MA, 02115, USA. Electronic address:

Many young people experience sexual debut before they are able to manage risk in order to avoid adverse consequences. Gender norms, social position, and power can undermine an adolescent's ability to exercise agency in their first sexual encounters and negotiate safer sexual behavior. This study examines the intersection of psychosocial and interpersonal factors with the social and physical environment to form an ecological understanding of how the determinants that shape sexual activity differ between boys and girls in two urban slums in Monrovia, Liberia. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.02.010DOI Listing
February 2019

Acute Respiratory Illness in Rural Haiti.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA; Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL. USA.

Objectives: Acute Respiratory Infection (ARI) is the most common cause of childhood morbidity and mortality in developing countries, including Haiti. Our objective was to detect pathogens found in children with ARI in rural Haiti to help develop evidence-based guidelines for treatment and prevention.

Methods: Retrospective study of students with ARI at four schools in rural Haiti. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.003DOI Listing
February 2019

A scoping review provided a framework for new ways of doing research through mobilizing collective intelligence.

J Clin Epidemiol 2019 Feb 14. Epub 2019 Feb 14.

INSERM, U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (CRESS), Methods of Therapeutic Evaluation of Chronic Diseases Team (METHODS), Paris, F-75014 France; Paris Descartes University, Sorbonne Paris Cité, France; Centre d'Epidémiologie Clinique, Hôpital Hôtel Dieu, Assistance Publique des Hôpitaux de Paris, Paris, France.

Objective: New forms of research involving collective intelligence (CI) of diverse individuals mobilized through crowdsourcing is successfully emerging in various fields. This scoping review aimed to describe these methods across different fields and propose a framework for implementation.

Study Design And Setting: We searched seven electronic databases for reports describing projects that had mobilized CI with crowdsourcing. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2019.02.007DOI Listing
February 2019

Procalcitonin-Guided Antibiotic Discontinuation and Mortality in Critically Ill Adults: A Systematic Review and Meta-Analysis.

Chest 2019 Feb 14. Epub 2019 Feb 14.

Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892.

Background: Procalcitonin (PCT)-guided antibiotic discontinuation appears to decrease antibiotic use in critically ill patients, but its impact on survival remains less certain.

Methods: We searched PubMed, EMBASE, Scopus, Web of Science, and CENTRAL for RCTs of PCT-guided antibiotic discontinuation in critically ill adults reporting survival or antibiotic duration. Searches were conducted without language restrictions from inception to 07/23/2018. Read More

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http://dx.doi.org/10.1016/j.chest.2018.12.029DOI Listing
February 2019

Trajectories of Accumulation of Health Deficits in Older Adults: Are There Variations According to Health Domains?

J Am Med Dir Assoc 2019 Feb 13. Epub 2019 Feb 13.

CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain.

Objectives: To analyze sex- and education-specific trajectories of health deficits accumulation (DA) throughout old age and to examine whether these trajectories differ according to health domains.

Design: Population-based prospective cohort study.

Setting: and participants: In Spain, 3228 community-dwelling individuals aged 60 years or older were followed up for 10 years. Read More

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http://dx.doi.org/10.1016/j.jamda.2018.12.023DOI Listing
February 2019

Association between Mapuche Ethnicity and Stroke: A Case-Control Study.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Center for Research in Cardiovascular and Nutritional Epidemiology (EPICYN), Universidad de La Frontera, Temuco, Chile; Department of Public Health, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile; Center of Excellence CIGES, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile.

Background: There is evidence of a greater incidence of stroke in native populations and minorities. A total of 34% of the population in the Araucanía Region is indigenous. The association between Mapuche ethnicity and stroke is unknown. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.029DOI Listing
February 2019

A call for better doctor-nurse collaboration: A qualitative study of the experiences of junior doctors and nurses in escalating care for deteriorating ward patients.

Aust Crit Care 2019 Feb 13. Epub 2019 Feb 13.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Clinical Research Centre, Block MD11, Level 2,10 Medical Drive, Singapore 117597.

Background: Despite the widespread implementation of medical emergency teams (METs) in hospitals to provide immediate interventions to deteriorating ward patients, little is known about how junior doctors and nurses escalate care for deteriorating ward patients in hospitals with established MET services.

Objectives: The objective of this research study was to explore the experiences of junior doctors and nurses in escalating care for clinically deteriorating patients in general wards.

Methods: Twenty-four individual interviews were conducted with 10 junior doctors and 14 registered nurses of a 1000-bed acute general hospital with the most established MET service in Singapore. Read More

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http://dx.doi.org/10.1016/j.aucc.2019.01.006DOI Listing
February 2019

Differences in Risk of Revision and Mortality Between Total and Unicompartmental Knee Arthroplasty. The Influence of Hospital Volume.

J Arthroplasty 2019 Jan 29. Epub 2019 Jan 29.

Agency for Heath Quality and Assessment of Catalonia (AQuAS), Barcelona, Spain; Health Services Research on Chronic Patients Network (REDISSEC), Madrid, Spain.

Background: The volume of arthroplasties performed in a hospital by year has an influence on the outcomes of total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA). The aims of this study are (1) to evaluate and compare the risk of revision and mortality of TKA and UKA and (2) to assess whether hospital volume is related to differences in revision risk and mortality.

Methods: All individuals recorded in the Catalan Arthroplasty Register between 1/1/2005 and 31/12/2016, diagnosed with osteoarthritis, undergoing cemented TKA and UKA were included. Read More

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http://dx.doi.org/10.1016/j.arth.2019.01.046DOI Listing
January 2019

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics.

J Am Acad Dermatol 2019 Feb 7. Epub 2019 Feb 7.

University of Alabama, Birmingham, Alabama.

Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations based on the available evidence. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.057DOI Listing
February 2019

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities.

J Am Acad Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Baylor Scott and White, Dallas, Texas.

Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations on the basis of available evidence. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.11.058DOI Listing
February 2019

Inadequate prenatal care utilization among women with and without methadone-treated opioid use disorders in Taiwan.

Int J Drug Policy 2019 Feb 13;67:1-8. Epub 2019 Feb 13.

Children and Family Research Center, National Taiwan University, Taipei, Taiwan.

Aims: The present study aims to investigate the utilization pattern of prenatal care and correlates for women with opioid use disorders (OUD) in Taiwan.

Method: Using the data linkage between the Methadone Maintenance Treatment (MMT) register with national health insurance, national birth notification system, and birth registration system, we identified 1712 pregnancies with 20 or more gestational weeks from women enrolled in the MMT (heroin-exposed: receiving no methadone treatment during pregnancy, n = 1053 by 882 women; methadone-treated: receiving methadone for at least one day during pregnancy, n = 659 by 574 women) and their 1:10 matched pregnancies from 17,060 women without substance use disorder in the period of 2004-2013. The generalized linear mixed models with negative binomial and logit distributions were performed to evaluate the relationship between individual sociodemographic, health, and addiction treatment characteristics with the number of prenatal visits and receiving prenatal care in the first trimester (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09553959193003
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http://dx.doi.org/10.1016/j.drugpo.2019.01.024DOI Listing
February 2019
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Tuberculosis screening for prospective migrants to high-income countries: systematic review of policies.

Public Health 2019 Feb 13;168:142-147. Epub 2019 Feb 13.

King's College London, School of Population Health and Environmental Sciences, London, UK.

Objective: To compare predeparture tuberculosis (TB) screening policies, including screening criteria and screening tests, and visa requirements for prospective migrants to high-income countries that have low to intermediate TB incidence and high immigration.

Study Design: Systematic review of policy documents.

Methods: We systematically identified high-income, high net-migration countries with an estimated TB incidence of <30 per 100,000. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.016DOI Listing
February 2019

Improving child weight management uptake through enhanced National Child Measurement Programme parental feedback letters: A randomised controlled trial.

Prev Med 2019 Feb 13. Epub 2019 Feb 13.

PHE Behavioural Insights Team (PHE BI), Research, Translation & Innovation Division, 6th Floor, Wellington House, 133-155 Waterloo Road, London SE1 8UG, United Kingdom of Great Britain and Northern Ireland.

This single-blind, pragmatic, cluster randomised controlled trial aims to investigate uptake of children's weight management services in response to enhanced National Child Measurement Programme (NCMP) letters providing weight status feedback to parents in three English counties in 2015. Parents of 2642 overweight or very overweight (obese) children aged 10-11 years received an intervention or control letter informing them of their child's weight status. Intervention letters included (i) a visual tool to help weight status recognition, (ii) a social norms statement, and for very overweight children, (iii) a prepopulated booking form for weight management services. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.01.023DOI Listing
February 2019

Emergency Department Patients are Receptive to Prayer-Based Interventions to Reduce Alcohol Use.

J Relig Health 2019 Feb 15. Epub 2019 Feb 15.

Center for Policy & Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health & Science University, Portland, OR, USA.

Previous studies show that elements of spirituality, including prayer and religious services, may contribute to reductions in harmful alcohol use. The objective of this study was to assess the acceptability of prayer as a component of emergency department (ED) interventions for risky alcohol use. A 12-question multiple-choice questionnaire was developed, piloted, and refined by the study team. Read More

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http://dx.doi.org/10.1007/s10943-019-00779-wDOI Listing
February 2019

Just choice: a Danielsian analysis of the aims and scope of prenatal screening for fetal abnormalities.

Med Health Care Philos 2019 Feb 15. Epub 2019 Feb 15.

Department of Health, Ethics and Society, GROW School for Oncology and Developmental Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, The Netherlands.

Developments in Non-Invasive Prenatal Testing (NIPT) and cell-free fetal DNA analysis raise the possibility that antenatal services may soon be able to support couples in non-invasively testing for, and diagnosing, an unprecedented range of genetic disorders and traits coded within their unborn child's genome. Inevitably, this has prompted debate within the bioethics literature about what screening options should be offered to couples for the purpose of reproductive choice. In relation to this problem, the European Society of Human Genetics (ESHG) and American Society of Human Genetics (ASHG) tentatively recommend that any expansion of this type of screening, as facilitated by NIPT, should be limited to serious congenital and childhood disorders. Read More

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http://dx.doi.org/10.1007/s11019-019-09888-5DOI Listing
February 2019

Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy.

Lab Invest 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Accumulation of abnormal tau in neurofibrillary tangles (NFT) occurs in Alzheimer disease (AD) and a spectrum of tauopathies. These tauopathies have diverse and overlapping morphological phenotypes that obscure classification and quantitative assessments. Recently, powerful machine learning-based approaches have emerged, allowing the recognition and quantification of pathological changes from digital images. Read More

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http://dx.doi.org/10.1038/s41374-019-0202-4DOI Listing
February 2019

Understanding skin absorption of common aldehyde vapours from exposure during hazardous material incidents.

J Expo Sci Environ Epidemiol 2019 Feb 15. Epub 2019 Feb 15.

Emergency Response TIPS, LLC, Alexandria, VA, USA.

The toxic release of aldehyde vapours during a hazardous material (HAZMAT) incident primarily results in respiratory concerns for the unprotected public. However, skin absorption may be an important concurrent exposure route that is poorly understood for this scenario. This study provides experimental data on the skin absorption properties of common aldehydes used in industry, including acetaldehyde, acrolein, benzaldehyde and formaldehyde, in gaseous or vapour form using an adapted in vitro technique. Read More

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http://dx.doi.org/10.1038/s41370-019-0127-4DOI Listing
February 2019

Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells.

Cell Death Dis 2019 Feb 15;10(3):147. Epub 2019 Feb 15.

Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA.

Fhit protein is lost in cancers of most, perhaps all, cancer types; when restored, it can induce apoptosis and suppress tumorigenicity, as shown in vitro and in mouse tumor models in vivo. Following protein cross-linking and proteomics analyses, we characterized a Fhit protein complex involved in triggering Fhit-mediated apoptosis. The complex includes the heat-shock chaperonin pair, HSP60/10, which is likely involved in importing Fhit into the mitochondria, where it interacts with ferredoxin reductase, responsible for transferring electrons from NADPH to cytochrome P450 via ferredoxin, in electron transport chain complex III. Read More

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http://dx.doi.org/10.1038/s41419-019-1414-7DOI Listing
February 2019

Establishing a generalized polyepigenetic biomarker for tobacco smoking.

Transl Psychiatry 2019 Feb 15;9(1):92. Epub 2019 Feb 15.

Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.

Large-scale epigenome-wide association meta-analyses have identified multiple 'signatures'' of smoking. Drawing on these findings, we describe the construction of a polyepigenetic DNA methylation score that indexes smoking behavior and that can be utilized for multiple purposes in population health research. To validate the score, we use data from two birth cohort studies: The Dunedin Longitudinal Study, followed to age-38 years, and the Environmental Risk Study, followed to age-18 years. Read More

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http://dx.doi.org/10.1038/s41398-019-0430-9DOI Listing
February 2019

Glycomacropeptide: long-term use and impact on blood phenylalanine, growth and nutritional status in children with PKU.

Orphanet J Rare Dis 2019 Feb 15;14(1):44. Epub 2019 Feb 15.

Dietetic Department, Birmingham Childrens Hospital, Steelhouse Lane, Birmingham, B4 6 NH, UK.

In phenylketonuria, casein glycomacropeptide (CGMP) requires modification with the addition of some essential and semi essential amino acids to ensure suitability as a protein substitute. The optimal amount and ratio of additional amino acids is undefined.

Aim: A longitudinal, parallel, controlled study over 12 months evaluating a CGMP (CGMP-AA2) formulation compared with phenylalanine-free L-amino acid supplements (L-AA) on blood Phe, Tyr, Phe:Tyr ratio, biochemical nutritional status and growth in children with PKU. Read More

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http://dx.doi.org/10.1186/s13023-019-1011-yDOI Listing
February 2019

A co-produced method to involve service users in research: the SUCCESS model.

BMC Med Res Methodol 2019 Feb 15;19(1):34. Epub 2019 Feb 15.

Centre for Innovative Ageing, College of Human and Health Science, Swansea University, Swansea, UK.

Background: Public and patient involvement is a routine element of health services research methods to produce better designed and reported studies. Although co-production is recommended when involving people in research, methods for involving people are usually designed and managed by researchers and there is little evidence about methods to co-produce models for effective public and patient involvement. We report the method used by a group of patient and carer service users to develop and implement a model for involving public members in research. Read More

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http://dx.doi.org/10.1186/s12874-019-0671-6DOI Listing
February 2019

Exploring barriers and challenges in protecting residential fire-related injuries: a qualitative study.

J Inj Violence Res 2019 Feb 16;11(1). Epub 2019 Feb 16.

Safety Promotion and Injury Prevention Research Center, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Building fires can be a great threat to the safety of residents, and can lead to economic and social damage. Exploring the views of stakeholders is a great source for understanding the factors that affect fires. The purpose of this study was to explore stakeholders' experiences of unintentional fire-related injuries in residential buildings in Iran. Read More

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http://dx.doi.org/10.5249/jivr.v11i1.1059DOI Listing
February 2019

A Telehealth-Enhanced Referral Process in Pediatric Primary Care: A Cluster Randomized Trial.

Pediatrics 2019 Feb 15. Epub 2019 Feb 15.

Center for Health Services and Society, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.

: media-1vid110.1542/5984243450001PEDS-VA_2018-2738 OBJECTIVES: To improve the mental health (MH) referral process for children referred from primary care to community mental health clinics (CMHCs) by using a community-partnered approach.

Methods: Our partners were a multisite federally qualified health center and 2 CMHCs in Los Angeles County. Read More

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http://dx.doi.org/10.1542/peds.2018-2738DOI Listing
February 2019

Randomised controlled trial of real-time feedback and brief coaching to reduce indoor smoking.

Tob Control 2019 Feb 15. Epub 2019 Feb 15.

Center for Behavioral Epidemiology and Community Health, Graduate School of Public Health, San Diego State University, San Diego, California, USA.

Background: Previous secondhand smoke (SHS) reduction interventions have provided only feedback on reported smoking behaviour, such as coaching, or presenting results from child cotinine assays or air particle counters.

Design: This SHS reduction trial assigned families at random to brief coaching and continuous real-time feedback (intervention) or measurement-only (control) groups.

Participants: We enrolled 298 families with a resident tobacco smoker and a child under age 14. Read More

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http://dx.doi.org/10.1136/tobaccocontrol-2018-054717DOI Listing
February 2019

Population-based outcomes of men with a single negative prostate biopsy: Importance of continued follow-up among older patients.

Urol Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgical Oncology, University Health Network, Toronto, ON, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.

Purpose: To determine in Ontario-based men with a single negative transrectal ultrasound-guided prostate biopsy the long-term rates of prostate cancer-specific mortality, diagnosis, and treatment; number of repeat biopsies; and predictors of prostate cancer diagnosis and mortality.

Materials And Methods: This was a population-based cohort study, using data from linked, validated health administrative databases, of all Ontario-based men with a negative first biopsy between January 1994 and October 2014. Patients were followed from time of first biopsy till death, administrative censoring, or end of study period. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.030DOI Listing
February 2019

Hospital Variation in Child Protection Reports of Substance Exposed Infants.

J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, University of Washington School of Public Health, Seattle, WA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA; Harborview Injury Prevention & Research Center, University of Washington, Seattle, WA.

Objective: To examine whether hospital-level factors contribute to discrepancies in reporting to Child Protective Services (CPS) of infants diagnosed with prenatal substance exposure.

Study Design: We used a linked dataset of birth, hospital, and CPS records using diagnostic codes (International Classification of Diseases, Ninth Revision) to identify infants diagnosed with prenatal substance exposure. Using multilevel models, we examined hospital-level and individual birth-level factors in relation to a report to CPS among those infants prenatally exposed to substances. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.065DOI Listing
February 2019

Pre- and post-operative antibiotics in conjunction with cytoreductive surgery and heated intraperitoneal chemotherapy (HIPEC) should be considered for pseudomyxoma peritonei (PMP) treatment.

Eur J Surg Oncol 2019 Jan 30. Epub 2019 Jan 30.

Department of Surgical Oncology, Mercy Medical Center, Baltimore, MD, 21202, USA. Electronic address:

Pseudomyxoma peritonei (PMP) is a subtype of peritoneal carcinomatosis that is traditionally treated by cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC). A growing body of evidence suggests that microbes are associated with various tumor types and have been found in organs and cavities that were once considered sterile. Prior and ongoing research from our consortium of PMP researchers strongly suggests that bacteria are associated with PMP tumors. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.223DOI Listing
January 2019

The Prognostic Significance of Puncture Timing to Survival of Arteriovenous Fistulas in Hemodialysis Patients: A Multicenter Retrospective Cohort Study.

J Clin Med 2019 Feb 15;8(2). Epub 2019 Feb 15.

Department of Nephrology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.

(1) Background: A functional shunt is critical to hemodialysis, but the ideal timing of shunt cannulation is still not established. In this study, we assessed the association between ideal puncture timing and shunt survival. (2) Methods: This retrospective cohort study using data from the Taiwan Health and Welfare database, which included 26885 hemodialysis patients with arteriovenous fistulas from 1 July 2008 to 30 June 2012. Read More

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http://dx.doi.org/10.3390/jcm8020247DOI Listing
February 2019

Comparing the Convergent and Concurrent Validity of the Dynamic Gait Index with the Berg Balance Scale in People with Multiple Sclerosis.

Healthcare (Basel) 2019 Feb 15;7(1). Epub 2019 Feb 15.

UAB/Lakeshore Research Collaborative; School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Recent clinical guidelines for adults with neurological disabilities suggest the need to assess measures of static and dynamic balance using the Berg Balance Scale (BBS) and Dynamic Gait Index (DGI) as core outcome measures. Given that the BBS measures both static and dynamic balance, it was unclear as to whether either of these instruments was superior in terms of its convergent and concurrent validity, and whether there was value in complementing the BBS with the DGI. : The objective was to evaluate the concurrent and convergent validity of the BBS and DGI by comparing the performance of these two functional balance tests in people with multiple sclerosis (MS). Read More

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http://dx.doi.org/10.3390/healthcare7010027DOI Listing
February 2019

Hierarchy of Factors Affecting the Condition and Development of Sports and Recreation Infrastructure-Impact on the Recreational Activity and Health of the Residents of a City (Poznan Case Study).

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

Poznan University of Physical Education, 61-871 Poznan, Poland.

The aim of the article is to identify which groups of factors (economic, social, and spatial) significantly determine the condition and development of the sports and recreation infrastructure of the city of Poznan and shape the needs and expectations of its residents. Standardized interviews among 39 service providers and 1159 service recipients made it possible to collect primary data on the presentation of the pace and directions of changes taking place in the sports and recreational facilities of the city, paying special attention to identifying and prioritizing factors determining this development. In order to establish the hierarchy of factors analyzed in the paper and operating within the same research problem for both groups of respondents (service recipients and service providers), the Anderson-Darling test was used. Read More

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http://dx.doi.org/10.3390/ijerph16040556DOI Listing
February 2019

Quality of life and psychological dysfunction in traumatized and nontraumatized patients with psychogenic nonepileptic seizures (PNES).

Epilepsy Behav 2019 Feb 12;92:341-344. Epub 2019 Feb 12.

CAPHRI School for Public Health and Primary Care, Department of Health Services Research, Maastricht University, Maastricht, the Netherlands; Centre for Economic Evaluation, Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, the Netherlands.

Objectives: Psychogenic nonepileptic seizures (PNES) have the appearance of epileptic seizures, yet show no epileptiform discharges in the brain. The quality of life (QOL) in patients with PNES is reportedly low and trauma eems to be a relevant risk factor. The objective of this study was to examine the difference between measures of (epilepsy-specific) QOL (Quality of Life in Epilepsy Inventory; QOLIE-31p) and psychological dysfunction (trauma symptom inventory; TSI) between patients with diagnosed PNES with self-reported trauma and those without self-reported trauma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183095
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http://dx.doi.org/10.1016/j.yebeh.2019.01.024DOI Listing
February 2019
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Characterization of normative angular joint kinematics during two functional upper limb tasks.

Gait Posture 2019 Jan 28;69:176-186. Epub 2019 Jan 28.

Department of Biomedical Engineering, University of Alberta, 1098 Research Transition Facility, Edmonton, Alberta T6G 2V2, Canada; Glenrose Rehabilitation Hospital, Alberta Health Services, 10230 111 Avenue NW, Edmonton, Alberta T5G 0B7, Canada; Department of Mechanical Engineering, University of Alberta, Donadeo Innovation Centre for Engineering, 9211 116 Street NW, Edmonton, Alberta T6G 1H9, Canada. Electronic address:

Background: Optical motion capture is a powerful tool for assessing upper body kinematics, including compensatory movements, in different populations. However, the lack of a standardized protocol with clear functional relevance hinders its clinical acceptance.

Research Question: The objective of this study was to use motion capture to: (1) characterize angular joint kinematics in a normative population performing two complex, yet standardized upper limb tasks with clear functional relevance; and (2) assess the protocol's intra-rater reliability. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.01.037DOI Listing
January 2019

Thrombelastography-Directed Transfusion in Cardiac Surgery: Impact on Postoperative Outcomes.

Ann Thorac Surg 2019 Feb 12. Epub 2019 Feb 12.

ProMedica Toledo Hospital, Department of Cardiothoracic Surgery. Electronic address:

Background: Transfusion of allogenic blood products is associated with significant morbidity and increased risk of mortality. Thrombelastography (TEG) to direct transfusion management during and immediately following cardiothoracic surgery reduced blood product usage in our institution. The goal of this study was to quantify the impact of TEG on postoperative outcomes. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.018DOI Listing
February 2019

Are B Cells Altered in the Decidua of Women with Preterm or Term Labor?

Am J Reprod Immunol 2019 Feb 15:e13102. Epub 2019 Feb 15.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA.

Problem: The immunophenotype of B cells at the maternal-fetal interface (decidua) in labor at term and preterm labor is poorly understood.

Method Of Study: Decidual tissues were obtained from women with preterm or term labor and from non-labor gestational age-matched controls. Immunophenotyping of decidual B cells was performed using multi-color flow cytometry. Read More

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http://dx.doi.org/10.1111/aji.13102DOI Listing
February 2019

Pre-exposure prophylaxis initiation and adherence among Black men who have sex with men (MSM) in three US cities: results from the HPTN 073 study.

J Int AIDS Soc 2019 Feb;22(2):e25223

Department of Human Development, State University of New York at BinghamtonBinghamton, NY, USA.

Introduction: Randomized clinical trials have demonstrated the efficacy of antiretroviral pre-exposure prophylaxis (PrEP) in preventing HIV acquisition among men who have sex with men (MSM). However, limited research has examined initiation and adherence to PrEP among Black MSM (BMSM) in the United States (US) who are disproportionately represented among newly HIV infected and late to care individuals. This research reports on the HIV Prevention Trials Network 073 (HPTN 073) study aimed to examine PrEP initiation, utilization and adherence among Black MSM utilizing the theoretically principled, culturally informed and client-centered care coordination (C4) model. Read More

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http://dx.doi.org/10.1002/jia2.25223DOI Listing
February 2019
5.090 Impact Factor

The prevalence of pressure ulcers in community-dwelling older adults: A study in an Indonesian city.

Int Wound J 2019 Feb 15. Epub 2019 Feb 15.

Department of Health Services Research and Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

The objectives of this study were to investigate the prevalence and the characteristics of pressure ulcers (PU) in community-dwelling older adults in Indonesia, including specific characteristics of the PU patients and their use of formal and informal care. A cross-sectional design was used for the study, with 325 participants aged 60 years or older, randomly chosen from the general community. The overall PU prevalence and the PU prevalence excluding category 1 were 10. Read More

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http://dx.doi.org/10.1111/iwj.13081DOI Listing
February 2019