32,898 results match your criteria Journal of HIV/AIDS & Social Services [Journal]


Practices That Support and Sustain Health in Schools: An Analysis of SHPPS Data.

J Sch Health 2019 Feb 19. Epub 2019 Feb 19.

Division of Adolescent and School Health, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 4770 Buford Highway NE (Mailstop F-78), Atlanta, GA 30329.

Background: The Whole School, Whole Community, Whole Child (WSCC) model provides an organizing framework for schools to develop and implement school health policies, practices, and programs. The purpose of this study was to examine the presence of practices that support school health for each component of the WSCC model in US schools.

Methods: Data from the School Health Policies and Practices Study 2014 were analyzed to determine the percentage of schools with practices in place that support school health for WSCC components. Read More

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http://dx.doi.org/10.1111/josh.12742DOI Listing
February 2019

Contraceptive use among HIV-positive and negative women: implication to end unintended pregnancy.

Contracept Reprod Med 2019 15;4. Epub 2019 Feb 15.

3Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: With the advancement of antiretroviral therapy and improved life expectancy, women living with HIV/AIDS are enjoying a better sexual life. Yet, the consistent utilization of contraceptive in such patients is highly recommended. There is paucity of data regarding contraceptive use among HIV-positive and negative women in Ethiopia. Read More

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http://dx.doi.org/10.1186/s40834-019-0084-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376717PMC
February 2019

Development, manufacture and characterization of niosomes for the delivery for nevirapine.

Pharmazie 2019 Feb;74(2):91-96

Nevirapine (NVP), used for the treatment of HIV/AIDS, exhibits unpredictable oral bioavailability, has a poor side effect profile and requires frequent dosing. Niosomes are novel drug delivery systems that have the potential to overcome these challenges. A thin layer hydration approach was used to produce niosomes and optimisation was undertaken using design of experiments (DoE) and response surface methodology (RSM) establish and identify parameters that may affect the manufacture of niosomes. Read More

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http://dx.doi.org/10.1691/ph.2019.8168DOI Listing
February 2019

Stigma and Dissatisfaction of Health Care Personnel in HIV Response in Iran: A Qualitative Study.

J Int Assoc Provid AIDS Care 2019 Jan-Dec;18:2325958219829606

5 Washington, USA.

Background And Aims:: With regard to the disease pandemics of HIV/AIDS, it is clear that there is need for prevention, treatment, care, and support of HIV positive patients in the health care system. In order to achieve these goals, job satisfaction should be a priority for health care staff. This study examined the problems of health care personnel and the behavior of patients undergoing HIV/AIDS counseling at Imam Khomeini Hospital in Tehran, Iran. Read More

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http://dx.doi.org/10.1177/2325958219829606DOI Listing
February 2019

Knowledge on STIs / HIV / AIDS, Stigma-Discrimination and sexual behaviors AMONG students of the University of Dschang, in Cameroon.

Ig Sanita Pubbl 2018 Sep-Oct;74(5):419-432

Faculty of Medicine, and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon.

This study reports the results of a survey conducted among students of the University of Dschang, on STI/HIV/AIDS, the Stigma-Discrimination pair and sexual behaviors.

Methods: This was a descriptive cross-sectional study conducted during the months of January and February 2017. We collected data by a face to face questionnaire administered to students of the University of Dschang. Read More

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February 2019

Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers.

Virology 2019 Feb 11;530:39-50. Epub 2019 Feb 11.

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Dept. of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic address:

HIV-1 Nef modulates the activation state of CD4 T cells by altering signaling events elicited by the T cell receptor (TCR). Primary nef sequences exhibit extensive inter-individual diversity that influences their ability to downregulate CD4 and HLA class I; however, the impact of nef variation on modulation of T cell signaling is poorly characterized. Here, we measured TCR-mediated activation of NFAT transcription factor in the presence of nef alleles isolated from 45 elite controllers (EC) and 46 chronic progressors (CP). Read More

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http://dx.doi.org/10.1016/j.virol.2019.02.008DOI Listing
February 2019

Unintended HIV-1 Transmission to a Sex Partner in a Study of a Therapeutic Vaccine Candidate.

J Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Centre Hospitalier Régional d'Orléans, Orléans, France.

We report a case of sexual transmission of human immunodeficiency virus (HIV) that occurred during treatment discontinuation in a therapeutic vaccine trial, following oral sex. Transmission occurred even though the index participant was an HIV/AIDS activist, particularly well informed about the risks and modalities of transmission. This case report highlights the risk of secondary transmission of HIV during cessation of treatment in HIV cure-related trials. Read More

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http://dx.doi.org/10.1093/infdis/jiz012DOI Listing
February 2019

Breast cancer in women living with HIV.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1158-1164

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

With the introduction of HAART, the life expectancy of the patients infected with HIV almost approached that of the general population. The incidence of certain HIV-Associated cancers as Kaposi Sarcoma (KS) and Non-Hodgkin Lymphoma (NHL) decreased, while an increase in Non-AIDS-Defining cancers (NADCs) has been documented. HIV infection is a risk factor for numerous cancers in PLWH. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17007DOI Listing
February 2019

Characteristics of Persons Who Inject Drugs with Recent HIV Infection in the United States: National HIV Behavioral Surveillance, 2012.

AIDS Behav 2019 Feb 18. Epub 2019 Feb 18.

Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS E-46, Atlanta, GA, 30333, USA.

We evaluated characteristics associated with recent HIV infection among persons who inject drugs (PWID) from 19 U.S. cities who participated in 2012 National HIV Behavioral Surveillance. Read More

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http://link.springer.com/10.1007/s10461-019-02420-z
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http://dx.doi.org/10.1007/s10461-019-02420-zDOI Listing
February 2019
1 Read

The Impact of Pre-Exposure Prophylaxis (PrEP) Use on Sexual Anxiety, Satisfaction, and Esteem Among Gay and Bisexual Men.

J Sex Res 2019 Feb 19:1-8. Epub 2019 Feb 19.

a Center for HIV/AIDS Educational Studies and Training , Hunter College of the City University of New York.

Gay and bisexual men (GBM) with heightened fears of human immunodeficiency virus (HIV) acquisition have reported high levels of sexual anxiety and low sexual self-esteem. Similarly, sexual satisfaction has been reported to be lower among some GBM who rely solely on condom use as HIV prevention. We sought to explore whether pre-exposure prophylaxis (PrEP) had an impact on the sexual satisfaction, anxiety, and esteem of GBM. Read More

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http://dx.doi.org/10.1080/00224499.2019.1572064DOI Listing
February 2019

Temporal Patterns in Chlamydia Repeat Testing in Massachusetts.

Am J Prev Med 2019 Mar;56(3):458-463

Department of Population Medicine, Harvard Medical School, Harvard University, and Harvard Pilgrim Health Care Institute, Boston, Massachusetts; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

Introduction: National guidelines recommend test-of-cure for pregnant women and test-of-reinfection for all patients with chlamydia infections in order to interrupt transmission and prevent adverse sequelae for patients, partners, and newborns. Little is known about retesting and positivity rates, and whether they are changing over time, particularly in private sector practices.

Methods: Electronic health record data on patients with chlamydia tests were extracted from three independent clinical practice groups serving ≅20% of the Massachusetts population. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.006DOI Listing

Developability assessment of physicochemical properties and stability profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 envelope glycoprotein trimers as candidate vaccine antigens.

J Pharm Sci 2019 Feb 15. Epub 2019 Feb 15.

International AIDS Vaccine Initiative, New York, NY 10004 USA. Electronic address:

The induction of broadly neutralizing antibodies (bNAb) is a major goal in the development of an effective vaccine against HIV-1. A soluble, trimeric, germline (gI) bNAb-targeting variant of the HIV-1 envelope glycoprotein (termed BG505 SOSIP.v4. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.01.033DOI Listing
February 2019

Ethical Considerations from the Viewpoint of Headquarters Experts on HIV/AIDS Prevention and Control Strategic Program.

Int J Prev Med 2019 15;10. Epub 2019 Jan 15.

Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The HIV control and prevention program is one of the Public Health programs that confronts with many ethical challenges. This study aimed to explore ethical considerations from the viewpoint of headquarters experts on HIV and AIDS prevention and control strategic plan.

Methods: In this qualitative study with content analysis design, focus group discussion method was utilized. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_275_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360846PMC
January 2019

They tell us "we don't belong in the world and we shouldn't take up a place": HIV discourse within two-spirit communities.

J Ethn Cult Divers Soc Work 2018 13;27(2):107-123. Epub 2017 Sep 13.

Indigenous Wellness Research Institute, University of Washington, Seattle, WA.

Objectives: We investigated how HIV discourse is negotiated and given meaning in the lives of young, male two-spirit leaders, when considering their communities' and their own health and wellness. These menare also unique in that they have always lived under the specter and dominant discourse of HIV, that is, they are part of a second generation since the time of HIV/AIDS.

Methods: We conducted a Discourse Analysis of six qualitative interviews from the HONOR Project, a multi-site, mixed-methods study of the two-spirit community across the United States, foregrounding the relationships amongst trauma, coping, and health. Read More

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http://dx.doi.org/10.1080/15313204.2017.1362616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377155PMC
September 2017

Is co-location of services with HIV care associated with improved HIV care outcomes? A systematic review.

AIDS Care 2019 Feb 18:1-9. Epub 2019 Feb 18.

a Division of HIV/AIDS Prevention , National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta , GA , USA.

This systematic review identifies models of service co-location, a structural intervention strategy to remove barriers to HIV care and services, and examines their associations with HIV care outcomes. A cumulative database (e.g. Read More

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http://dx.doi.org/10.1080/09540121.2019.1576847DOI Listing
February 2019

Estimating HIV incidence from surveillance data indicates a second wave of infections in Brazil.

Epidemics 2019 Feb 7. Epub 2019 Feb 7.

Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, United Kingdom.

Emerging evidence suggests that HIV incidence rates in Brazil, particularly among men, may be rising. Here we use Brazil's integrated health systems data to develop a mathematical model, reproducing the complex surveillance systems and providing estimates of HIV incidence, number of people living with HIV (PLHIV), reporting rates and ART initiation rates. An age-structured deterministic model with a flexible spline was used to describe the natural history of HIV along with reporting and treatment rates. Read More

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http://dx.doi.org/10.1016/j.epidem.2019.02.002DOI Listing
February 2019

Mozambique's Community Antiretroviral Therapy Support Group Program: The Role of Social Relationships in Facilitating HIV/AIDS Treatment Retention.

AIDS Behav 2019 Feb 15. Epub 2019 Feb 15.

The Lewis Family Foundation, Boston, MA, USA.

The Community Antiretroviral (ARV) Therapy Support Group (CASG) program aims to address low retention rates in Mozambique's HIV treatment program and the absorptive capacity of the country's health facilities. CASG provides patients with the opportunity to form groups, whose members provide peer support and collect ARV medications on a rotating basis for one another. Based on the promising results in one province, a multi-site level evaluation followed. Read More

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http://dx.doi.org/10.1007/s10461-019-02419-6DOI Listing
February 2019
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Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.

Nat Commun 2019 Feb 15;10(1):763. Epub 2019 Feb 15.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.

The N-terminal fusion peptide (FP) of the human immunodeficiency virus (HIV)-1 envelope glycoprotein (Env) gp41 subunit plays a critical role in cell entry. However, capturing the structural flexibility in the unbound FP is challenging in the native Env trimer. Here, FP conformational isomerism is observed in two crystal structures of a soluble clade B transmitted/founder virus B41 SOSIP. Read More

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http://dx.doi.org/10.1038/s41467-019-08738-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377653PMC
February 2019
1 Read

Reproductive health services utilization and its associated factors among secondary school youths in Woreta town, South Gondar, North West Ethiopia: a cross sectional study.

BMC Res Notes 2019 Feb 15;12(1):90. Epub 2019 Feb 15.

Department of Surgical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Objective: The aim of this study was to assess reproductive health service utilization and its associated factors among secondary school students in Woreta town, South Gondar, North east Ethiopia 2018.

Result: Out of the total 376 selected students, 345 were participated in the study with a response rate of 94%. Of these respondents, 85 (24. Read More

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http://dx.doi.org/10.1186/s13104-019-4129-zDOI Listing
February 2019

A superiority of viral load over CD4 cell count when predicting mortality in HIV patients on therapy.

BMC Infect Dis 2019 Feb 15;19(1):169. Epub 2019 Feb 15.

Department of Mathematical Statistics and Actuarial Sciences, University of the Free State, Box 339, Bloemfontein, 9300, South Africa.

Background: CD4 cell count has been identified to be an essential component in monitoring HIV treatment outcome. However, CD4 cell count monitoring sometimes fails to predict virological failure resulting in unnecessary switch of treatment lines which causes drug resistance and limitations of treatment options. This study assesses the use of both viral load (HIV RNA) and CD4 cell count in the monitoring of HIV/AIDS progression. Read More

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http://dx.doi.org/10.1186/s12879-019-3781-1DOI Listing
February 2019

Pre-exposure prophylaxis initiation and adherence among Black men who have sex with men (MSM) in three US cities: results from the HPTN 073 study.

J Int AIDS Soc 2019 Feb;22(2):e25223

Department of Human Development, State University of New York at BinghamtonBinghamton, NY, USA.

Introduction: Randomized clinical trials have demonstrated the efficacy of antiretroviral pre-exposure prophylaxis (PrEP) in preventing HIV acquisition among men who have sex with men (MSM). However, limited research has examined initiation and adherence to PrEP among Black MSM (BMSM) in the United States (US) who are disproportionately represented among newly HIV infected and late to care individuals. This research reports on the HIV Prevention Trials Network 073 (HPTN 073) study aimed to examine PrEP initiation, utilization and adherence among Black MSM utilizing the theoretically principled, culturally informed and client-centered care coordination (C4) model. Read More

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http://dx.doi.org/10.1002/jia2.25223DOI Listing
February 2019
5.090 Impact Factor

Onward transmission of multiple HIV-1 unique recombinant forms among men who have sex with men in Beijing, China.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

Background: Unique recombinant forms (URFs) were generated in dually-infected or multiply-infected individuals, and some of URFs can be transmitted to many people resulting in the emergence of circulating recombinant forms (CRFs). We examined whether there was evidence for onward transmission of multiple URFs among men who have sex with men (MSM) in Beijing.

Methods: A total of 146 MSM subjects with acute/early HIV-1 infection were recruited from the Beijing PRIMO clinical cohort between September 2010 and July 2012. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001983DOI Listing
February 2019
1 Read

The problem of lost to follow-up of mother-child pairs enrolled in the PMTCT program in Dschang District Hospital-Cameroon.

Ig Sanita Pubbl 2018 Jul-Aug;74(4):337-347

Department of Biomedical Sciences, Faculty of Science, University of Dschang, PO Box 67 Dschang, Cameroon.

High rates of lost to follow-up (LTFU) in the Prevention of Mother-To-Child Transmission of HIV (PMTCT) programs in Cameroon will only contribute in hindering the successful implementation of the program. The objective of this study was to determine the reasons of LTFU of mother-child pairs enrolled in the PMTCT program in Dschang District Hospital (DDH): Cameroon. Methods: A retrospective cohort study was carried out in HIV+ exposed children delivered in the DDH from1st Jan 2012 - 31st Dec 2014, who were greater than or equal to 18 months at the study period (1st August - 30th September 2016) and whose mothers were enrolled in the PMTCT program for at least 3 months. Read More

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February 2019
4 Reads

Knowledge, attitude, willingness of HIV counseling and testing and factors associated with it, among long distant drivers in Enugu, Nigeria: an opportunity in reduction of HIV prevalence.

Afr Health Sci 2018 Dec;18(4):1088-1097

College of Medicine, University of Nigeria, Enugu campus, Community Medicine.

Background: Long distance truck drivers (LDTDs) have been one of the key forces in the spread of HIV/AIDS across the African continent.

Objective: We set out to assess the knowledge of HIV transmission route, preventive measures, attitude to HIV Counseling and Testing (HCT), willingness and factors associated with willingness to screen for HIV among long distance truck drivers in Enugu, Nigeria.

Method: This was a cross-sectional study of 500 long distance truck drivers aged 19-65 years. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354848PMC
December 2018

HIV transmission networks among transgender women in Los Angeles County, CA, USA: a phylogenetic analysis of surveillance data.

Lancet HIV 2019 Feb 11. Epub 2019 Feb 11.

Department of Medicine, University of California, San Diego, CA, USA.

Background: Transgender women are among the groups at highest risk for HIV infection, with a prevalence of 27·7% in the USA; and despite this known high risk, undiagnosed infection is common in this population. We set out to identify transgender women and their partners in a molecular transmission network to prioritise public health activities.

Methods: Since 2006, HIV protease and reverse transcriptase gene (pol) sequences from drug resistance testing have been reported to the Los Angeles County Department of Public Health and linked to demographic data, gender, and HIV transmission risk factor data for each case in the enhanced HIV/AIDS Reporting System. Read More

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http://dx.doi.org/10.1016/S2352-3018(18)30359-XDOI Listing
February 2019

Implementation science and stigma reduction interventions in low- and middle-income countries: a systematic review.

BMC Med 2019 Feb 15;17(1). Epub 2019 Feb 15.

Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.

Background: Interventions to alleviate stigma are demonstrating effectiveness across a range of conditions, though few move beyond the pilot phase, especially in low- and middle-income countries (LMICs). Implementation science offers tools to study complex interventions, understand barriers to implementation, and generate evidence of affordability, scalability, and sustainability. Such evidence could be used to convince policy-makers and donors to invest in implementation. Read More

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http://dx.doi.org/10.1186/s12916-018-1237-xDOI Listing
February 2019

Can mental health treatments help prevent or reduce intimate partner violence in low- and middle-income countries? A systematic review.

BMC Womens Health 2019 Feb 14;19(1):34. Epub 2019 Feb 14.

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, HH795, Baltimore, MD, 21205, USA.

Background: Epidemiological research suggests an interrelationship between mental health problems and the (re)occurrence of intimate partner violence (IPV). However, little is known about the impact of mental health treatments on IPV victimization or perpetration, especially in low- and middle-income countries (LMIC).

Methods: We conducted a systematic review to identify prospective, controlled studies of mental health treatments in LMIC. Read More

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http://dx.doi.org/10.1186/s12905-019-0728-zDOI Listing
February 2019

Participatory praxis as an imperative for health-related stigma research.

BMC Med 2019 Feb 15;17(1):32. Epub 2019 Feb 15.

Uganda Youth Coalition on Adolescent SRHR and HIV, Busia, Uganda.

Background: Participatory praxis is increasingly valued for the reliability, validity, and relevance of research results that it fosters. Participatory methods become an imperative in health-related stigma research, where the constitutive elements of stigma, healthcare settings, and research each operate on hierarchies that push those with less social power to the margins.

Discussion: Particularly for people who are stigmatized, participatory methods balance the scales of equity by restructuring power relationships. Read More

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http://dx.doi.org/10.1186/s12916-019-1263-3DOI Listing
February 2019

Men's Refashioning of Masculine Identities in Uganda and Their Self-Management of HIV Treatment.

Authors:
Steve Russell

Qual Health Res 2019 Feb 14:1049732318823717. Epub 2019 Feb 14.

1 University of East Anglia, Norwich, United Kingdom.

Studies in sub-Saharan Africa show that masculine identities contribute to men's relatively lower uptake of HIV services. Although useful, these studies pay less attention to men's agency to negotiate and refashion masculine identities which better suit their lives as men living with HIV. In this article, I analyze the refashioning of masculine identities among men living with HIV in Uganda, adjustment processes which helped their self-management, and adherence to treatment. Read More

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http://dx.doi.org/10.1177/1049732318823717DOI Listing
February 2019

Determination of medication adherence and related factors among people living with HIV/AIDS in a Turkish university hospital

Turk J Med Sci 2019 Feb 11;49(1):198-205. Epub 2019 Feb 11.

Background/aim: Widespread use of antiretroviral treatment (ART) has led to decrease in the incidence of HIV/AIDS-related mortality. Besides the availability of ART, medication adherence is essential for treatment success. There is a scarcity of data reported from Turkey regarding ART adherence among people living with HIV/AIDS (PLWHA). Read More

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http://dx.doi.org/10.3906/sag-1802-137DOI Listing
February 2019

Increased Methamphetamine, Injection Drug, and Heroin Use Among Women and Heterosexual Men with Primary and Secondary Syphilis - United States, 2013-2017.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):144-148. Epub 2019 Feb 15.

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC.

During 2013-2017, the national annual rate of reported primary and secondary (P&S) syphilis cases in the United States increased 72.7%, from 5.5 to 9. Read More

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http://dx.doi.org/10.15585/mmwr.mm6806a4DOI Listing
February 2019
2 Reads

Chronic medical conditions in U.S. adults with incarceration history.

Authors:
Tomoko Udo

Health Psychol 2019 Mar;38(3):217-225

University at Albany, State University of New York.

Objectives: To examine the associations between incarceration history and chronic medical conditions in a nationally representative sample of U.S. adults and whether risk for chronic medical conditions differ by sex and race among those with incarceration history. Read More

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http://doi.apa.org/getdoi.cfm?doi=10.1037/hea0000720
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http://dx.doi.org/10.1037/hea0000720DOI Listing
March 2019
3 Reads

Polypharmacy and drug-related problems among people living with HIV/AIDS: a single-center experience

Turk J Med Sci 2019 Feb 11;49(1):222-229. Epub 2019 Feb 11.

Background/aim: The HIV-infected population is aging, and the concomitant comorbidities increase the likelihood of polypharmacy. There is a scarcity of data for determining drug-related problems in people living with HIV/AIDS (PLWHA).

Materials And Methods: This cross-sectional study was carried out between 1 September 2015 and 1 July 2016. Read More

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http://dx.doi.org/10.3906/sag-1807-295DOI Listing
February 2019

Resistance and Tolerance to Cryptococcal Infection: An Intricate Balance That Controls the Development of Disease.

Front Immunol 2019 29;10:66. Epub 2019 Jan 29.

Translational Research in Respiratory Diseases Program, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.

is a ubiquitous environmental yeast and a leading cause of invasive fungal infection in humans. The most recent estimate of global disease burden includes over 200,000 cases of cryptococcal meningitis each year. expresses several virulence factors that may have originally evolved to protect against environmental threats, and human infection may be an unintended consequence of these acquired defenses. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361814PMC
January 2019
1 Read

Patient and Provider Perspectives on 30-Day Readmissions, Preventability, and Strategies for Improving Transitions of Care for Patients with HIV at a Safety Net Hospital.

J Int Assoc Provid AIDS Care 2019 Jan-Dec;18:2325958219827615

2 Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Thirty-day hospital readmissions, a key quality metric, are common among people living with HIV. We assessed perceived causes of 30-day readmissions, factors associated with preventability, and strategies to reduce preventable readmissions and improve continuity of care for HIV-positive individuals. Patient, provider, and staff perspectives toward 30-day readmissions were evaluated in semistructured interviews (n = 86) conducted in triads (HIV-positive patient, medical provider, and case manager) recruited from an inpatient safety net hospital. Read More

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http://dx.doi.org/10.1177/2325958219827615DOI Listing
February 2019

Community health workers trained to conduct verbal autopsies provide better mortality measures than existing surveillance: Results from a cross-sectional study in rural western Uganda.

PLoS One 2019 13;14(2):e0211482. Epub 2019 Feb 13.

Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, United States of America.

Background: In much of sub-Saharan Africa, health facilities serve as the primary source of routine vital statistics. These passive surveillance systems, however, are plagued by infrequent and unreliable reporting and do not capture events that occur outside of the formal health sector. Verbal autopsies (VA) have been utilized to estimate the burden and causes of mortality where civil registration and vital statistics systems are weak, but VAs have not been widely employed in national surveillance systems. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211482PLOS
February 2019

Therapeutic effect of double plasma molecular adsorption system and sequential half-dose plasma exchange in patients with HBV-related acute-on-chronic liver failure.

J Clin Apher 2019 Feb 13. Epub 2019 Feb 13.

Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.

Objective: The artificial liver support system (ALSS) is used frequently as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). This study aims to compare the therapeutic efficacy of double plasma molecular adsorption system (DPMAS) with sequential half-dose plasma exchange (PE) (DPMAS+PE) and full-dose PE in patients with HBV-ACLF.

Methods: A total of 131 hospitalized patients who were diagnosed with HBV-ACLF and underwent DPMAS+PE or PE were retrospectively analyzed. Read More

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http://dx.doi.org/10.1002/jca.21690DOI Listing
February 2019
1 Read

Community Levels of PrEP Use Among Men Who Have Sex with Men by Race/Ethnicity, San Francisco, 2017.

AIDS Behav 2019 Feb 13. Epub 2019 Feb 13.

San Francisco Department of Public Health, San Francisco, CA, USA.

Efforts in San Francisco are maximizing the use of pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) where high levels of use are needed to maximize reducing new HIV infections. National HIV Behavioral Surveillance surveys MSM in San Francisco. Demographics, health care and risk behaviors are assessed. Read More

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http://dx.doi.org/10.1007/s10461-019-02428-5DOI Listing
February 2019

The MomConnect Nurses and Midwives Support Platform (NurseConnect): A Qualitative Process Evaluation.

JMIR Mhealth Uhealth 2019 Feb 13;7(2):e11644. Epub 2019 Feb 13.

Wits Reproductive Health and HIV Institute, University of Witwatersrand, Johannesburg, South Africa.

Background: Over the past decade, mobile health has steadily increased in low-income and middle-income countries. However, few platforms have been able to sustainably scale up like the MomConnect program in South Africa. NurseConnect was created as a capacity building component of MomConnect, aimed at supporting nurses and midwives in maternal and child health. Read More

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http://dx.doi.org/10.2196/11644DOI Listing
February 2019

A provider-observed tool to assess Oral Hygiene Skill Mastery (OHSIM) in human immunodeficiency virus-positive (HIV+) adults.

Spec Care Dentist 2019 Feb 13. Epub 2019 Feb 13.

Department of Family Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Aims: Periodontal diseases (PDs) affect nearly half of Americans ≥30 years old and are common in human immunodeficiency virus-positive (HIV+) adults. A validated measure of oral hygiene skill could improve tailored prevention-focused health communication.

Methods: We developed Oral Hygiene Skill Mastery (OHSIM), a provider-observed measure of toothbrushing and flossing ability. Read More

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http://dx.doi.org/10.1111/scd.12355DOI Listing
February 2019

Disseminated CMV infection and HLH in a patient with well-controlled HIV and ulcerative colitis.

BMJ Case Rep 2019 Feb 11;12(2). Epub 2019 Feb 11.

Department of Genitourinary Medicine and HIV, Imperial College Healthcare NHS Trust, London, UK.

We present a case of haemophagocytic lymphohistiocytosis (HLH) in the context of disseminated cytomegalovirus (CMV) viraemia in a 50-year-old man with well-controlled HIV infection and ulcerative colitis (UC), for which he was receiving azathioprine. Peak CMV viral load was 371 000 copies/ml with evidence of end-organ CMV in the lungs and colon. A bone marrow biopsy showed evidence of haemophagocytosis of platelets, neutrophils and erythrocytes. Read More

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http://dx.doi.org/10.1136/bcr-2018-227916DOI Listing
February 2019
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Multifocal Necrotizing Leukoencephalopathy: Expanding the Clinicopathologic Spectrum.

J Neuropathol Exp Neurol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia.

Multifocal necrotizing leukoencephalopathy (MNL) is a rare condition typically described in patients undergoing chemotherapy or with HIV/AIDS. As a pathologic entity, it is characterized by multiple small foci of necrosis typically within white matter of the pons and occasionally in other areas. Herein we describe findings in 6 patients with MNL, 5 diagnosed at postmortem examination and 1 by surgical biopsy. Read More

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http://dx.doi.org/10.1093/jnen/nlz003DOI Listing
February 2019

The New Orleans Alcohol Use in HIV [NOAH] Study: Launching a translational investigation of the interaction of alcohol use with biological and socioenvironmental risk factors for multi-morbidity in people living with HIV.

Alcohol Clin Exp Res 2019 Feb 12. Epub 2019 Feb 12.

LSUHSC-NO Comprehensive Alcohol-HIV/AIDS Research Center.

Background: Alcohol use disorders (AUDs) are highly prevalent in persons living with HIV (PLWH) and are associated with increased HIV risk behaviors, suboptimal treatment adherence, potential interaction with medication pharmacodynamics, and greater risk for disease progression. Preclinical studies show that chronic binge alcohol administration accelerates disease progression and aggravates pathogenesis in the simian immunodeficiency virus (SIV)-infected rhesus macaque model despite viral suppression by antiretroviral therapy.

Methods: To translate preclinical findings in the rhesus macaque model of chronic binge alcohol administration and SIV infection and to address areas of uncertainty surrounding the biological mechanisms and socioenvironmental modifiers that contribute to the relationship between alcohol use and HIV-associated comorbidities, precocious aging, and disease progression, we designed a translational multi-project, longitudinal, cohort study, the New Orleans Alcohol Use in HIV [NOAH] Study. Read More

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http://doi.wiley.com/10.1111/acer.13980
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http://dx.doi.org/10.1111/acer.13980DOI Listing
February 2019
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Substance Use Screening in HIV Care Settings: a Review and Critique of the Literature.

Curr HIV/AIDS Rep 2019 Feb 12. Epub 2019 Feb 12.

Addiction Sciences Division, Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Purpose Of Review: People living with human immunodeficiency virus/AIDS (PLWHA) experience high prevalence of substance use disorders (SUD). HIV care settings represent a unique opportunity to identify possible SUD, to provide SUD interventions, and to improve linkage to SUD treatment. The aims of this paper are to (a) review and critique the extant literature examining substance use screening approaches among PLWHA in HIV care settings and (b) provide recommendations for future clinical practice. Read More

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http://dx.doi.org/10.1007/s11904-019-00434-9DOI Listing
February 2019

Durability of first-line antiretroviral regimens in the era of integrase inhibitors: a cohort of HIV-positive individuals in Spain, 2014-2015.

Antivir Ther 2019 Feb 12. Epub 2019 Feb 12.

Hospital Universitario Ramon y Cajal, Madrid, Spain.

Background: We compared time to treatment change (TC), viral suppression (VS) and change in CD4+ T-cell counts of first-line antiretroviral regimens (ART).

Methods: We analyzed HIV treatment-naïve adults from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) initiating the most commonly used ART regimens from September 2014 to November 2015. We used proportional hazards models on the sub-distribution hazard to estimate sub-distribution hazard ratios (sHR) for time to TC, logistic regression to estimate odds ratios (ORs) for VS (viral load<50 copies/ml), and linear regression to assess mean differences in CD4 changes from ART initiation. Read More

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http://dx.doi.org/10.3851/IMP3297DOI Listing
February 2019

Quinoline-based protein-protein interaction inhibitors of LEDGF/p75 and HIV integrase: An in silico study.

Curr Top Med Chem 2019 Feb 8. Epub 2019 Feb 8.

Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, 151001. India.

The failure of the Integrase Strand Transfer Inhibitors (INSTIs) due to the mutations occurring at catalytic site of HIV integrase (IN) has led to the design of allosteric integrase inhibitors (ALLINIs). Lens epithelium derived growth factor (LEDGF/p75) is the host cellular cofactor helps chaining IN to the chromatin. The protein-protein interactions (PPIs) were observed at allosteric site (LEDGF/p75 binding domain) between LEDGF/p75 of host cell and IN of virus. Read More

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http://dx.doi.org/10.2174/1568026619666190208164801DOI Listing
February 2019
3.402 Impact Factor

Pattern of and reasons for antiretroviral therapy regimen change among adult HIV/AIDS patients at regional hospital in Eastern Ethiopia: A 10-year retrospective study.

SAGE Open Med 2019 1;7:2050312119827092. Epub 2019 Feb 1.

Addis Private Pharmacy, Harar, Ethiopia.

Objectives: Despite the successes of treatment with antiretroviral therapy in reducing morbidity and mortality among HIV-infected patients, long-term sustainability of the initial regimen has become challenging. Therefore, this study is aimed to address pattern of and reasons for change of antiretroviral therapy regimens among HIV/AIDS patients at Jugel Hospital, Eastern Ethiopia.

Methods: A retrospective cross-sectional study was conducted to review medical records of 220 patients who had been on treatment and experienced regimen change at least once from September 2006 to August 2016. Read More

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http://dx.doi.org/10.1177/2050312119827092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360642PMC
February 2019
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[Epidemiological characteristics of molecular transmission cluster among reported HIV/AIDS cases in Jiaxing city, Zhejiang province, 2017].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Feb;40(2):202-206

Department of AIDS/STD Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.

To understand the epidemiological characteristics of one large HIV molecular transmission cluster in Jiaxing city, Zhejiang province, 2017 in order to select those people under high-risk and providing basis for programs on prevention. During 2017, newly diagnosed HIV/AIDS cases in this city were recruited. Plasma samples were collected from subjects, followed by RNA extraction, RT-PCR and nest-PCR for gene amplification, before being sequenced and aligned. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.02.015DOI Listing
February 2019

[Spatio-temporal distribution and correlation of reported cases of hepatitis C and HIV/AIDS in China, 2012-2017].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Feb;40(2):155-159

Division of Hepatitis C/STD Prevention and Treatment, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To compare the time and spatial distribution of hepatitis C and HIV/AIDS cases and its correlation, in China from 2012 to 2017. Data on reported hepatitis C and HIV/AIDS cases was gathered from the Direct Reporting System of Infectious Diseases Information Network in China, 2012 to 2017 while annually collected provincial data was based on the date of review and current address. Correlation of the data was analyzed, using both simple correlation and linear regression methods. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.02.006DOI Listing
February 2019

Associations between drug use patterns and viral load suppression among HIV-positive individuals who use support services in New York City.

Drug Alcohol Depend 2019 Jan 15;197:15-21. Epub 2019 Jan 15.

New York City Department of Health and Mental Hygiene, Bureau of HIV/AIDS Prevention and Control, 42-09 28th Street, Queens, NY, 11101-4132, USA.

Background: Drug use (DU) represents a significant barrier to maintaining physical health among people living with HIV (PLWH). Few studies, however, have examined the relationship between DU over time and HIV treatment outcomes. Such studies are needed because an individual's risk of poor health outcomes may vary with their DU behaviors. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.12.015DOI Listing
January 2019