33,245 results match your criteria Journal of HIV/AIDS & Social Services [Journal]


AIDS prevention and control in the Yunnan region by T cell subset assessment.

PLoS One 2019 18;14(4):e0214800. Epub 2019 Apr 18.

Yunnan Key Laboratory of Laboratory Medicine, Kunming, Yunan, China.

Background: Prior to being spread throughout broader China, multiple human immunodeficiency virus (HIV)-1 genotypes were originally discovered in the Yunnan Province. As the HIV-1 epidemic continues its spread in Yunnan, knowledge of the influence of gender, age, and ethnicity to instances of HIV reservoirs will benefit monitoring the spread of HIV.

Methods: The degree to which T cells are depleted during an HIV infection depends on the levels of immune activation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214800PLOS

Motivating HIV Providers in Vietnam to Learn: A Mixed-Methods Analysis of a Mobile Health Continuing Medical Education Intervention.

JMIR Med Educ 2019 Apr 18;5(1):e12058. Epub 2019 Apr 18.

Department of Global Health, Boston University School of Public Health, Boston, MA, United States.

Background: The Mobile Continuing Medical Education Project (mCME V.2.0) was a randomized controlled trial designed to test the efficacy of a text messaging (short message service [SMS])-based distance learning program in Vietnam that included daily quiz questions, links to readings and online courses, and performance feedback. Read More

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http://dx.doi.org/10.2196/12058DOI Listing

Implementing Web-Based Interventions in HIV Primary Care Clinics: Pilot Implementation Evaluation of Positive Health Check.

JMIR Form Res 2019 Apr 18;3(2):e10688. Epub 2019 Apr 18.

Center for Communication Science, RTI International, Durham, NC, United States.

Background: Web-based interventions can help people living with HIV achieve better clinical outcomes and behaviors, but integrating them into clinical practice remains challenging. There is a gap in understanding the feasibility of implementing these interventions in HIV clinic settings from the clinicians' perspective.

Objective: The goal of the research was to determine whether Positive Health Check (PHC)-a Web-based, tailored video counseling tool focused on increasing patient adherence and retention in care and reducing HIV risk among HIV-positive patients-was acceptable, appropriate, and feasible for HIV primary care clinic staff to implement in clinic workflows. Read More

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http://dx.doi.org/10.2196/10688DOI Listing

Bisexual Lives and Aging in Context: A Cross-National Comparison of the United Kingdom and the United States.

Int J Aging Hum Dev 2019 Apr 18:91415019843661. Epub 2019 Apr 18.

2 The Open University, Milton Keynes, UK.

Research on bisexual histories and identities in later life is limited and reflects only single-nation studies. This article compares findings from two independently conducted studies of bisexual aging, in the United Kingdom and the United States, using a discourse analytic and life course perspective. The goals were to compare how participants narrated and made sense of their bisexual experiences in later life and to examine ways in which historical and cultural contexts shaped their accounts. Read More

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http://dx.doi.org/10.1177/0091415019843661DOI Listing

Timeliness of HIV Diagnosis and Antiretroviral Treatment Initiation in the Era of Universal Test and Treat.

J Infect Dis 2019 Apr 4. Epub 2019 Apr 4.

Institute for Implementation Science in Population Health (ISPH), City University of New York (CUNY); New York City, New York USA.

Background: We describe the timing of HIV diagnosis and antiretroviral treatment (ART) initiation following implementation of universal test and treatment policies in New York City (NYC).

Methods: Using NYC population-based HIV Registry data for persons diagnosed from 2012 through 2015 and followed through June 2017, we examined trends in the proportion diagnosed early following HIV infection (i.e. Read More

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http://dx.doi.org/10.1093/infdis/jiz148DOI Listing

Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein.

ACS Med Chem Lett 2019 Apr 7;10(4):463-468. Epub 2018 Dec 7.

Department of Biotechnology, Chemistry and Pharmacy, "Department of Excellence 2018-2022", University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

Small molecule inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested 18 NC inhibitors (NCIs) bearing a double functionalization. In these NCIs, one part of the molecule is deputed to interact noncovalently with the NC hydrophobic pocket, while the second portion is designed to interact with the N-terminal domain of NC. Read More

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00506
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http://dx.doi.org/10.1021/acsmedchemlett.8b00506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466545PMC
April 2019
1 Read

Chronic cough and cystic lung disease caused by in a patient with AIDS.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Pulmonary and Critical Care Medicine, University of Maryland Medical Center, Baltimore, Maryland, USA.

A 24-year-old man with a history of HIV and large B cell lymphoma (currently in remission) presented with fever, dry cough and dizziness. His CD4+ count was undetectable, and the HIV viral load was 109 295 cop/mL. Physical examination revealed fever, hypotension and tachycardia with coarse breath sounds in the middle and lower chest zones bilaterally. Read More

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http://dx.doi.org/10.1136/bcr-2018-228741DOI Listing

Molecular Epidemiology of HIV-1 Subtype G in the Russian Federation.

Viruses 2019 Apr 16;11(4). Epub 2019 Apr 16.

Central Research Institute of Epidemiology, 111123 Moscow, Russia.

Although HIV-1 subtype A has predominated in Russia since the end of the 20th century, other viral variants also circulate in this country. The dramatic outbreak of HIV-1 subtype G in 1988-1990 represents the origin of this variant spreading in Russia. However, full genome sequencing of the nosocomial viral variant and an analysis of the current circulating variants have not been conducted. Read More

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http://dx.doi.org/10.3390/v11040348DOI Listing

Assessing HIV/AIDS Knowledge, Awareness and Attitudes among Senior High School Students in Kuwait.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objectives: An estimated 1.8 million individuals worldwide became newly infected with human immunodeficiency virus (HIV) in 2016, which amounts to 5,000 new infections per day. This includes 160,000 children. Read More

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http://dx.doi.org/10.1159/000500307DOI Listing
April 2019
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Stigma and discrimination related to gender identity and vulnerability to HIV/AIDS among transgender women: a systematic review.

Cad Saude Publica 2019 8;35(4):e00112718. Epub 2019 Apr 8.

Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brasil.

HIV prevalence among transgender women is disproportional when compared to the general population in various countries. Stigma and discrimination based on gender identity have frequently been associated with vulnerability to HIV/AIDS. The objective was to conduct a systematic literature review to analyze the relationship between stigma and discrimination related to gender identity in transgender women and vulnerability to HIV/AIDS. Read More

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http://dx.doi.org/10.1590/0102-311X00112718DOI Listing

Experiences of HIV-infected adults and healthcare providers with healthcare delivery practices that influence engagement in US primary healthcare settings: a qualitative systematic review.

JBI Database System Rev Implement Rep 2019 Apr 15. Epub 2019 Apr 15.

School of Nursing, Rutgers, The State University of New Jersey, Newark, USA.

Introduction: The human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is a major public health problem that has claimed the lives of more than 34 million people worldwide. The health of people living with HIV (PLWH) is optimized by ongoing engagement in HIV care, yet many people living with HIV either do not enter or fall out of care. Access to care and ongoing engagement in care for antiretroviral (ARV) medication adherence and psychoeducational support are critical to achieving the desired outcomes of reducing the risk of further HIV transmission and HIV related morbidity and mortality, and managing other commonly co-occurring health, social and behavioral conditions, thereby maximizing wellness. Read More

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http://dx.doi.org/10.11124/JBISRIR-2017-003756DOI Listing
April 2019
1 Read

Estimation of the Population Size of Men Who Have Sex With Men in Vietnam: Social App Multiplier Method.

JMIR Public Health Surveill 2019 Apr 17;5(2):e12451. Epub 2019 Apr 17.

Centers for Disease Control and Prevention, Hanoi, Vietnam.

Background: Although the prevalence of HIV among men who have sex with men (MSM) in Vietnam has been increasing in recent years, there are no estimates of the population size of MSM based on tested empirical methods.

Objective: This study aimed to estimate the size of the MSM population in 12 provinces in Vietnam and extrapolate from those areas to generate a national population estimate of MSM. A secondary aim of this study was to compare the feasibility of obtaining the number of users of a mobile social (chat and dating) app for MSM using 3 different approaches. Read More

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http://dx.doi.org/10.2196/12451DOI Listing

Rural South African Community Perceptions of Antibiotic Access and Use: Qualitative Evidence from a Health and Demographic Surveillance System Site.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Public Health Sciences, Global Health (IHCAR), Karolinska Institutet, Stockholm, Sweden.

Knowledge and practices of rural South African populations with regard to antibiotic access and use (ABACUS) remain understudied. By using the case of four villages in the north east of the country, our aim was to investigate popular notions and social practices related to antibiotic use to inform patient-level social interventions for appropriate antibiotic use. To achieve this, we investigated where community members (village residents) were accessing and sourcing medication, and what they understood antibiotics and antibiotic resistance (ABR) to be. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0171DOI Listing

The Ethics of Breastfeeding by Women Living with HIV/AIDS: A Concrete Proposal for Reforming Department of Health and Human Services Recommendations.

J Law Med Ethics 2019 Mar;47(1):161-164

Lawrence O. Gostin, J.D., LL.D. (Hon.), is O'Neill Professor of Global Health Law, Director of the O'Neill Institute for National and Global Health Law, and Director of the World Health Organization Collaborating Center on Public Health Law and Human Rights. President Obama appointed Prof. Gostin to the National Cancer Advisory Board. Matthew M. Kavanagh, Ph.D., is a visiting professor at Georgetown University Law Center and director of the Global Health Policy and Governance Initiative at the O'Neill Institute.

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http://dx.doi.org/10.1177/1073110519840496DOI Listing
March 2019
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Fighting against HIV and AIDS within a resource constrained rural setting: a case study of the Ruvheneko Programme in Chirumhanzu, Zimbabwe.

SAHARA J 2019 Dec;16(1):25-34

a Department of Sociology , University of Johannesburg , Johannesburg , South Africa.

Since reports of the first incidence of the HIV virus in Zimbabwe in 1985, the epidemic has negatively impacted on every facet of human security. Rural areas, by virtue of being the periphery and constrained in terms of resources and health care provision, bear the brunt of the epidemic. In light of the above background, this paper examined how the establishment of Ruvheneko Programme by the people of Chirumhanzu helped in mitigating on the impact of HIV and AIDS in the rural sphere. Read More

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https://www.tandfonline.com/doi/full/10.1080/17290376.2019.1
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http://dx.doi.org/10.1080/17290376.2019.1605537DOI Listing
December 2019
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Model-Based Methods to Translate Adolescent Medicine Trials Network for HIV/AIDS Interventions Findings Into Policy Recommendations: Rationale and Protocol for a Modeling Core (ATN 161).

JMIR Res Protoc 2019 Apr 16;8(4):e9898. Epub 2019 Apr 16.

Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, United States.

Background: The United States Centers for Disease Control and Prevention estimates that approximately 60,000 US youth are living with HIV. US youth living with HIV (YLWH) have poorer outcomes compared with adults, including lower rates of diagnosis, engagement, retention, and virologic suppression. With Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) support, new trials of youth-centered interventions to improve retention in care and medication adherence among YLWH are underway. Read More

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http://dx.doi.org/10.2196/resprot.9898DOI Listing

Psychosocial Factors Associated with Food Insufficiency Among People Living with HIV/AIDS (PLWH) Initiating ART in Ethiopia.

AIDS Behav 2019 Apr 15. Epub 2019 Apr 15.

Institute for Implementation Science in Population Health, City University of New York, 55 West 125th Street, New York, NY, 10027, USA.

Food insufficiency is associated with suboptimal HIV treatment outcomes. Less is known about psychosocial correlates of food insufficiency among PLWH. This sample includes 1176 adults initiating antiretroviral therapy at HIV clinics in Ethiopia. Read More

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http://dx.doi.org/10.1007/s10461-019-02505-9DOI Listing

Predicting Retention in HIV Primary Care: Is There a Missed Visits Continuum Based on Patient Characteristics?

AIDS Behav 2019 Apr 15. Epub 2019 Apr 15.

University of Michigan, Ann Arbor, MI, USA.

Missing 3 + scheduled HIV primary care visits over a 1-year period increases mortality risk for people living with HIV (PLWH). We used electronic health data from PLWH (≥ 18 years old) at a southeastern US HIV clinic in 2016 to examine differences across patient-level characteristics and number of missed visits (1-2 vs. 0, 3 + vs. Read More

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http://dx.doi.org/10.1007/s10461-019-02508-6DOI Listing

Prevalence of drug resistance mutations among ART-naive and -experienced HIV-infected patients in Sierra Leone.

J Antimicrob Chemother 2019 Apr 15. Epub 2019 Apr 15.

Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur)-Complexo Hospitalario Universitario de Vigo, SERGAS-UVigo, Vigo, Spain.

Objectives: The aim of this study was to assess the prevalence of HIV drug resistance (HIVDR) in HIV-infected ART-naive and -experienced patients in Sierra Leone.

Patients And Methods: We conducted a cross-sectional study of HIV-positive adults aged ≥18 years at Connaught Hospital in Freetown, Sierra Leone in November 2017. Sequencing was performed in the reverse transcriptase, protease and integrase regions, and interpreted using the Stanford HIVDR database and WHO 2009 mutation list. Read More

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http://dx.doi.org/10.1093/jac/dkz134DOI Listing

Risk factors for death among children 0-59 months of age with moderate-to-severe diarrhea in Manhiça district, southern Mozambique.

BMC Infect Dis 2019 Apr 15;19(1):322. Epub 2019 Apr 15.

Centro de Investigação em Saúde de Manhiça (CISM), Rúa 12, Vila da Manhiça, 1929, Maputo, CP, Mozambique.

Background: Despite major improvements in child survival rates, the number of deaths due to diarrhea remains unacceptably high. We aimed to describe diarrhea-associated mortality and evaluate risk factors for death among Mozambican children with moderate-to-severe diarrhea (MSD).

Methods: Between December 2007 and November 2012, children under-five with MSD were enrolled in Manhiça district, as part of the Global Enteric Multicenter study (GEMS). Read More

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http://dx.doi.org/10.1186/s12879-019-3948-9DOI Listing

Effect of multiple intervention models on uptake of HIV testing services and sexual behaviour among residents of military cantonments in south-east Nigeria.

Afr J AIDS Res 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Department of Community Medicine , Federal Teaching Hospital Abakaliki , Nigeria.

Background: HIV testing and counselling (HTC) has been a viable tool in controlling the spread of HIV/AIDS, and serves as the entry point in the HIV care and treatment cascade. In Africa, HIV-related morbidity and mortality are high with thousands still unaware of their HIV status. This study assessed the effect of on-site multiple HIV control interventions on the uptake of HTC services, knowledge and sexual behaviour among residents of two military cantonments [barracks] in south-east Nigeria. Read More

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https://www.tandfonline.com/doi/full/10.2989/16085906.2019.1
Publisher Site
http://dx.doi.org/10.2989/16085906.2019.1586738DOI Listing
April 2019
1 Read

The birds and the bees: do Puerto Rican mothers and daughters talk about sex?

Arch Clin Med Case Rep 2018 9;2(6):190-205. Epub 2018 Nov 9.

UPR School of Medicine-CEMI, San Juan, PR.

Introduction: Effective communication skills that foster responsible sexual decisions are known to have the potential to reduce the risky adolescent sexual behavior. It is well understood that maternal communication is a key element in modifying the adolescent sexual behavior. The objective of this qualitative study was to explore if Puerto Rican mothers of adolescent girls have conversations about sexuality with their daughters and the content of such conversations. Read More

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http://www.fortunejournals.com/articles/pthe-birds-and-the-b
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http://dx.doi.org/10.26502/acmcr.96550043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461385PMC
November 2018
1 Read

Differences between groups of pre-exposure prophylaxis (PrEP) using couples in HIV-negative/unknown relationships.

J Acquir Immune Defic Syndr 2019 Apr 11. Epub 2019 Apr 11.

Center for HIV/AIDS Educational Studies & Training, Hunter College of the City University of New York (CUNY), New York, NY, USA.

Background: Epidemiology research is limited on the characteristics of HIV pre-exposure prophylaxis (PrEP) using couples.

Setting: United States nationwide sample recruited online in 2017.

Methods: HIV-negative/unknown gay, bisexual, and other men who have sex with men (GBMSM) with HIV-negative/unknown partners (n=3140) were asked about individual and main partner PrEP uptake. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002058DOI Listing

Trajectories of sexual identity development and psychological well-being for highly sexually active gay and bisexual men: A latent growth curve analysis.

Psychol Sex Orientat Gend Divers 2019 Mar 20;6(1):64-74. Epub 2018 Sep 20.

The Center for HIV/AIDS Educational Studies & Training (CHEST), Hunter College of the City University of New York (CUNY), New York, NY, USA.

Objective: Examining sexual identity development-the process through which sexual minorities discover and disclose their sexual orientations-within a minority stress framework may help to contextualize sexual and mental health disparities among gay and bisexual men. Research on sexual identity development has typically focused on ages of achieving specific milestones (i.e. Read More

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http://dx.doi.org/10.1037/sgd0000308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456266PMC

Knowledge about menstrual hygiene, sexual health, and contraception in educated late adolescent age girls.

J Family Med Prim Care 2019 Feb;8(2):610-613

Department of Obstetrics and Gynecology, Yashodha Hospital, Somajiguda, Hyderabad, Telangana, India.

Aim: Adolescents are future generation of our country. It is a vulnerable age making them susceptible to many health issues such as reproductive tract infections because of improper menstrual hygiene, sexually transmitted infections (STIs), human immunodeficiency virus (HIV), unexpected pregnancies because of lack of awareness about contraceptive practices, and no proper guidance about sexual health. The aim of this study is to assess the knowledge of college-going adolescent girls regarding menstrual hygiene and their awareness about HIV/AIDS, other STIs, and also their knowledge about contraception. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_320_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436312PMC
February 2019

Oral Histories, Public Engagement, and the Making of .

Authors:
Janet Weston

Hist Workshop J 2019 21;87:211-223. Epub 2019 Feb 21.

How might creative practices surrounding oral history contribute to public engagement and to historical research itself? These questions are considered here through a reflective account of the making of the audio drama . is based on oral histories of HIV/AIDS in the Republic of Ireland, gathered in 2016-17 as part of the Wellcome Trust-funded project 'Prisons, Medical Care and Entitlement to Health in England and Ireland, 1850-2000'. This piece reviews the processes and practical considerations behind the making of the audio drama and its associated launch events, alongside a summary of the history of HIV/AIDS and of prisons that was being produced and shared. Read More

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https://academic.oup.com/hwj/article/doi/10.1093/hwj/dbz009/
Publisher Site
http://dx.doi.org/10.1093/hwj/dbz009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459366PMC
February 2019
1 Read

Sexual Partner Characteristics, Relationship Type, and HIV Risk Among a Community Venue-based Sample of Urban Adolescent and Young Adult Men Who Have Sex with Men.

Youth Soc 2019 Mar 20;51(2):219-246. Epub 2016 Sep 20.

Johns Hopkins Children's Center, Johns Hopkins University, Baltimore, MD.

Few studies have examined sexual partnerships and HIV risk in diverse samples of African American/black and Hispanic/Latino adolescent and young adult men who have sex with men (YMSM), a group that have a high burden of HIV in the U.S. A community-venue recruitment approach was used, which identified significant differences in HIV risk by sexual partner type among 1215 YMSM. Read More

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http://dx.doi.org/10.1177/0044118X16669259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456077PMC

Focal Intramedullary Spinal Cord Lesion in HIV/AIDs: Toxoplasmosis vs. Lymphoma.

World Neurosurg 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurosurgery, Santa Clara Valley Medical Center, San Jose, CA 95128; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305. Electronic address:

Background: Neurological complications are common in HIV/AIDS patients. While both the central nervous system (CNS) and the peripheral nervous system (PNS) can be affected, up to 80% of HIV/AIDS patients have CNS involvement during the course of their illness. The brain is the primary site of HIV/AIDS associated CNS complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193104
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http://dx.doi.org/10.1016/j.wneu.2019.04.057DOI Listing
April 2019
1 Read

Quantifying the Risk of Undetected HIV, Hepatitis B Virus, or Hepatitis C Virus Infection in Public Health Service Increased Risk Donors.

Am J Transplant 2019 Apr 13. Epub 2019 Apr 13.

Division of Healthcare Quality and Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.

To reduce the risk of HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) transmission through organ transplantation, donors are universally screened for these infections by nucleic acid tests (NAT). Deceased organ donors are classified as "increased risk" if they engaged in specific behaviors during the 12 months before death. We developed a model to estimate the risk of undetected infection for HIV, HBV, and HCV among NAT-negative donors specific to the type and timing of donors' potential risk behavior to guide revisions to the 12-month timeline. Read More

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http://dx.doi.org/10.1111/ajt.15393DOI Listing

Long-term loss to follow-up in the TREAT Asia HIV Observational Database (TAHOD).

HIV Med 2019 Apr 12. Epub 2019 Apr 12.

Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia.

Objectives: With earlier antiretroviral therapy (ART) initiation, time spent in HIV care is expected to increase. We aimed to investigate loss to follow-up (LTFU) in Asian patients who remained in care 5 years after ART initiation.

Methods: Long-term LTFU was defined as LTFU occurring after 5 years on ART. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hiv.12734
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http://dx.doi.org/10.1111/hiv.12734DOI Listing
April 2019
2 Reads
3.988 Impact Factor

Exploring Social Determinants of Health as Predictors of Mortality During 2012-2016, Among Black Women with Diagnosed HIV Infection Attributed to Heterosexual Contact, United States.

J Racial Ethn Health Disparities 2019 Apr 12. Epub 2019 Apr 12.

Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, 1600 Clifton Rd., Mailstop E-47, Atlanta, GA, 30329, USA.

Background: In 2016, black women with HIV infection attributed to heterosexual contact accounted for 47% of all women living with diagnosed HIV, and 41% of deaths that occurred among women with diagnosed HIV in the USA that year. Social determinants of health have been found to be associated with mortality risk among people with HIV. We analyzed the role social determinants of health may have on risk of mortality among black women with HIV attributed to heterosexual contact. Read More

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http://dx.doi.org/10.1007/s40615-019-00589-6DOI Listing

Retention in care and mortality trends among patients receiving comprehensive care for HIV infection: a retrospective cohort study.

CMAJ Open 2019 Apr-Jun;7(2):E236-E245. Epub 2019 Apr 12.

BC Centre for Excellence in HIV/AIDS (Ulloa, Puskas, Yip, Zhang, Lima, Montaner, Guillemi, Barrios); John Ruedy Immunodeficiency Clinic (Stanley, Stone, Pedromingo), St. Paul's Hospital; Division of AIDS (Lima, Montaner), Department of Family Practice (Guillemi) and School of Population and Public Health (Barrios), University of British Columbia, Vancouver, BC

Background: Studies examining the relation between comprehensive care and health outcomes associated with comorbidities unrelated to HIV infection have focused mainly on the health outcomes of HIV-infected people and comorbid substance use disorders. We aimed to assess the impact of retention in comprehensive HIV infection care on overall, AIDS-related and non-AIDS-related mortality.

Methods: Using a retrospective cohort design, we collected data for HIV-infected patients aged 19 years or more who first visited a comprehensive HIV infection clinic in Vancouver between Jan. Read More

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http://cmajopen.ca/lookup/doi/10.9778/cmajo.20180136
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http://dx.doi.org/10.9778/cmajo.20180136DOI Listing
April 2019
1 Read

Cervical cancer screening among women living with HIV: a cross-sectional study using the baseline questionnaire data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS).

CMAJ Open 2019 Apr-Jun;7(2):E217-E226. Epub 2019 Apr 12.

Chronic Viral Illness Service (de Pokomandy, Bakombo, Proulx-Boucher), McGill University Health Centre; Department of Family Medicine (de Pokomandy, O'Brien), McGill University, Montréal, Que.; Department of Family and Community Medicine (Burchell), St. Michael's Hospital; Department of Family and Community Medicine (Burchell), University of Toronto, Toronto, Ont.; Faculty of Health Sciences (Salters, Kaida), Simon Fraser University, Burnaby, BC; BC Centre for Excellence in HIV/AIDS (Salters, Ding, Kaida), Vancouver, BC; Department of Obstetrics and Gynecology (Boucoiran), Hôpital Sainte-Justine and Université de Montréal, Montréal, Que.; Oak Tree Clinic (Pick), BC Women's Hospital; Department of Family Practice (Ogilvie), School of Population and Public Health, University of British Columbia, Vancouver, BC; Women's College Research Institute (Loutfy), Women's College Hospital; Faculty of Medicine (Loutfy), University of Toronto, Toronto, Ont.

Background: Cisgender women with HIV experience an elevated risk of cervical cancer compared with HIV-negative women, but this cancer can be prevented through regular cervical cancer screening. Our study objective was to measure adherence to current national cervical cancer screening guidelines among women with HIV in 3 Canadian provinces and identify factors associated with delays.

Methods: We conducted a cross-sectional study using the baseline questionnaire of the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS). Read More

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http://dx.doi.org/10.9778/cmajo.20180151DOI Listing

Factors associated with risk of HIV-infection among pregnant women in Cameroon: Evidence from the 2016 national sentinel surveillance survey of HIV and syphilis.

PLoS One 2019 12;14(4):e0208963. Epub 2019 Apr 12.

National AIDS Control Committee, Yaoundé, Cameroon.

Background: Human Immunodeficiency Virus infection (HIV) remains a public health concern in Cameroon that requires regular surveillance for informed policy-making to guide programmatic interventions. Using data from the 2016 HIV national sentinel survey in Cameroon, we ascertained HIV prevalence and factors associated with risk of infection among pregnant women.

Methods: A cross-sectional study was conducted throughout 2016 in the 10 regions of Cameroon, targeting 7000 first antenatal care (ANC-1) attendees (4000 from urban and 3000 from rural areas) in 60 sentinel health facilities. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208963PLOS

Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen.

Antivir Ther 2019 Apr 12. Epub 2019 Apr 12.

Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

Background: Pre-cART (combined antiretroviral therapy) plasma viral load >500,000 copies/mL has been associated with a lower probability of achieving virological suppression, while few data about its role on maintenance of virological suppression are available. In this study we aimed to clarify whether high levels of pre-cART viremia are associated with virological rebound (VR) after virological suppression.

Methods: HIV-infected individuals who achieved virological suppression after first-line cART were included. Read More

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http://dx.doi.org/10.3851/IMP3309DOI Listing
April 2019
1 Read

High incidence and low case detection rate among contacts of tuberculosis cases in Shanghai, China.

BMC Infect Dis 2019 Apr 11;19(1):320. Epub 2019 Apr 11.

Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.

Background: To assess the effect of a contact investigation strategy by assessing the incidence of tuberculosis and the case detection rate among contacts of tuberculosis patients.

Methods: The pulmonary tuberculosis incidence among contacts was determined retrospectively from a tuberculosis information management system. For each detection method (symptom examination only, symptom examination plus chest radiography or other alternatives), the detection rate of pulmonary tuberculosis patients among contacts was derived from contact investigation form records. Read More

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http://dx.doi.org/10.1186/s12879-019-3942-2DOI Listing

Ways of coping and HIV disclosure among people living with HIV: mediation of decision self-efficacy and moderation by sex.

AIDS Care 2019 Apr 12:1-10. Epub 2019 Apr 12.

e Department of Mental Health Law and Policy, College of Behavioral and Community Sciences , University of South Florida , Tampa , FL , USA.

Individuals living with HIV/AIDS face several stressors and use varying strategies to cope. Disclosure (or nondisclosure) of HIV serostatus is an important consideration among individuals living with HIV. However, studies examining the association between coping and HIV disclosure are lacking, and more research examining potential mediators and moderators is needed. Read More

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http://dx.doi.org/10.1080/09540121.2019.1605045DOI Listing

An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.

Cell Host Microbe 2019 Apr;25(4):578-587.e5

Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA. Electronic address:

The HIV-1 envelope glycoprotein (Env) (gp120-gp41) is the target for neutralizing antibodies and antibody-dependent cellular cytotoxicity (ADCC). HIV-1 Env is flexible, sampling different conformational states. Before engaging CD4, Env adopts a closed conformation (State 1) that is largely antibody resistant. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19313128193011
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http://dx.doi.org/10.1016/j.chom.2019.03.002DOI Listing
April 2019
4 Reads
12.328 Impact Factor

Levels of resilience and delivery of HIV care in response to urban violence and crime.

J Adv Nurs 2019 Apr 11. Epub 2019 Apr 11.

School of Public Health, University of the Western Cape, South Africa, Robert Sobukwe Road, Bellville, Cape Town, South Africa.

Aims: To understand the impact of urban violence and crime on HIV care delivery.

Background: Urban violence and crime can put pressure on the health care system and on nursing staff. Whilst the impact this has at the individual level has been researched, there is less research that places this within the context of the overall social eco-system. Read More

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http://dx.doi.org/10.1111/jan.14022DOI Listing

Gridlock from diagnosis to treatment of multidrug-resistant tuberculosis in Tanzania: low accessibility of molecular diagnostic services and lack of healthcare worker empowerment in 28 districts of 5 high burden TB regions with mixed methods evaluation.

BMC Public Health 2019 Apr 11;19(1):395. Epub 2019 Apr 11.

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, USA.

Background: Multidrug-resistant tuberculosis (MDR-TB) outcomes are adversely impacted by delay in diagnosis and treatment.

Methods: Mixed qualitative and quantitative approaches were utilized to identify healthcare system related barriers to implementation of molecular diagnostics for MDR-TB. Randomly sampled districts from the 5 highest TB burden regions were enrolled during the 4th quarter of 2016. Read More

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http://dx.doi.org/10.1186/s12889-019-6720-6DOI Listing
April 2019
52 Reads
2.264 Impact Factor

The Effects of Socio-demographic Characteristics on Indonesian Women's Knowledge of HIV/AIDS: A Cross-sectional Study.

J Prev Med Public Health 2019 Mar 28;52(2):109-114. Epub 2019 Feb 28.

Department of Biostatistics of Public Health, Airlangga University, Surabaya, Indonesia.

Objectives: The purpose of this study was to characterize Indonesian women's knowledge of HIV/AIDS and to investigate the effects of socio-demographic characteristics thereupon with the goal of supporting the prevention and early detection of HIV/AIDS.

Methods: This cross-sectional study was conducted using secondary data from the standard Indonesian Demographic and Health Survey (IDHS) in 2012. A total of 34 984 subjects ranged in age from 15 years to 49 years. Read More

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http://dx.doi.org/10.3961/jpmph.18.256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459757PMC

Disparities in Viral Suppression and Medication Adherence among Women in the USA, 2011-2016.

AIDS Behav 2019 Apr 9. Epub 2019 Apr 9.

Division of HIV/AIDS Prevention, DHAP/NCHHSTP/CDC, Centers for Disease Control and Prevention, 1600 Clifton Rd NE MS E-45, Atlanta, GA, 30333, USA.

We assessed disparities in viral suppression (VS) and antiretroviral therapy (ART) adherence among women of the HIV Outpatient Study to inform HIV treatment strategies. We used adjusted prevalence ratios (aPR) with 95% confidence intervals (CI) to assess VS by race/ethnicity and generalized estimating equations to investigate factors associated with not achieving VS and ART non-adherence. Among 426 women (median age = 46 years), at baseline, VS was less prevalent among black women (63%) compared with Hispanic women/Latinas (73%) and white women (78%). Read More

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http://link.springer.com/10.1007/s10461-019-02494-9
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http://dx.doi.org/10.1007/s10461-019-02494-9DOI Listing
April 2019
4 Reads

Increased HIV diagnoses in West Virginia counties highly vulnerable to rapid HIV dissemination through injection drug use: a cautionary tale.

Ann Epidemiol 2019 Mar 6. Epub 2019 Mar 6.

Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address:

Purpose: To investigate HIV transmission potential from a cluster of HIV infections among men who have sex with men to persons who inject drugs in 15 West Virginia counties. These counties were previously identified as highly vulnerable to rapid HIV dissemination through injection drug use (IDU) associated with high levels of opioid misuse.

Methods: We interviewed persons with 2017 HIV diagnoses about past-year risk behaviors and elicited sexual, IDU, and social contacts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10472797193008
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http://dx.doi.org/10.1016/j.annepidem.2019.02.012DOI Listing
March 2019
1 Read

Providing care for trans women with HIV/AIDS in Peru.

Authors:
Barbara Fraser

Lancet 2019 Apr 4;393(10179):1399-1400. Epub 2019 Apr 4.

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http://dx.doi.org/10.1016/S0140-6736(19)30806-2DOI Listing

Regulatory B lymphocytes: development and modulation of the host immune response during disease.

Immunotherapy 2019 Apr 10. Epub 2019 Apr 10.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, 8000.

The role of B lymphocytes (B cells) in immunogenic responses has become increasingly important over the past decade, focusing on a new B-cell subtype: regulatory B-cells (B). These B have been shown to possess potent immunosuppressive activities and have identified as key players in disease control and immune tolerance. In this review, the occurrence of B type in various conditions, along with evidence supporting discovered functions and proposed purposes will be explored. Read More

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https://www.futuremedicine.com/doi/10.2217/imt-2018-0185
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http://dx.doi.org/10.2217/imt-2018-0185DOI Listing
April 2019
4 Reads

Community-Based Organization Adaptations to the Changing HIV Prevention and Care Landscape in the Southern United States.

AIDS Educ Prev 2018 Dec;30(6):516-527

Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

Community-based organizations (CBOs) provide HIV prevention services throughout the United States, including the South where HIV/AIDS burden is high. We assessed Southern CBO response to changes in the HIV prevention landscape, including the National HIV/AIDS Strategy, and the Centers for Disease Control and Prevention's (CDC's) High Impact Prevention. Both strategies aim to improve outcomes for people living with or at high risk for HIV. Read More

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http://dx.doi.org/10.1521/aeap.2018.30.6.516DOI Listing
December 2018

Development and Implementation of an HIV Health Care Practice Transformation Model for Latinos.

AIDS Educ Prev 2018 Dec;30(6):502-515

La Clínica del Pueblo, Washington, D.C.

A Latino Community Health Center in Washington, D.C. implemented and evaluated a practice transformative model to optimize human resources and improve quality health outcomes in HIV service delivery for Latino patients. Read More

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http://dx.doi.org/10.1521/aeap.2018.30.6.502DOI Listing
December 2018
1 Read

"The Time Has Arrived": Perceptions of Behavioral Adjustments in the Context of Pre-Exposure Prophylaxis Availability Among Adolescents in South Africa.

AIDS Educ Prev 2018 Dec;30(6):463-473

Department of Behavioral and Social Sciences, Brown University School of Public Health.

Antiretroviral pre-exposure prophylaxis (PrEP) holds enormous potential to reduce HIV acquisition in key populations globally. We conducted an exploratory PrEP acceptability study using qualitative methodology among adolescents and service providers in the Western Cape Province of South Africa to inform future PrEP implementation challenges in South Africa and other high-prevalence African countries. Semistructured focus groups and in-depth individual interviews were conducted among 57 adolescents 16-17 years of age, living with and without HIV, and 25 clinical service providers. Read More

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http://dx.doi.org/10.1521/aeap.2018.30.6.463DOI Listing
December 2018

Changes in Disparities in Estimated HIV Incidence Rates Among Black, Hispanic/Latino, and White Men Who Have Sex With Men (MSM) in the United States, 2010-2015.

J Acquir Immune Defic Syndr 2019 May;81(1):57-62

Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Atlanta, Georgia.

Background: During 2008-2015, the estimated annual HIV incidence rate in the United States decreased for each transmission risk category, except for men who have sex with men (MSM). Racial/ethnic disparities exist, with higher incidence rates for Black and Hispanic/Latino MSM.

Setting: This analysis examines changes, 2010-2015, in disparities of HIV incidence among Black, Hispanic/Latino and White MSM. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001977DOI Listing
May 2019
3 Reads