8,290 results match your criteria Journal of Groups in Addiction & Recovery [Journal]


Veterans with PTSD and comorbid substance use disorders: Does single versus poly-substance use disorder affect treatment outcomes?

Drug Alcohol Depend 2019 Apr 9;199:70-75. Epub 2019 Apr 9.

Department of Behavioral Sciences and Psychiatry, Division of Addiction Sciences, Medical University of South Carolina, 5 Charleston Center Dr., Suite 151, Charleston, SC, 29401 USA; Ralph H. Johnson VA Medical Center, 109 Bee St., Charleston, SC, 29401 USA.

Introduction: Substance use disorders (SUD) frequently co-occur with posttraumatic stress disorder (PTSD). Little is known, however, about how individuals with a single SUD diagnosis (relating to only one substance) compare to individuals with poly-SUD diagnoses (relating to more than one substance) on substance use and PTSD treatment outcomes. To address this gap in the literature, we utilized data from a larger study investigating a 12-week integrated, exposure-based treatment (i. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.04.001DOI Listing

Cognitive functions in Internet addiction - a review.

Psychiatr Pol 2019 Feb 28;53(1):61-79. Epub 2019 Feb 28.

Katolicki Uniwersytet Lubelski Jana Pawła II.

The Internet, being generally available, is used by all age groups for professional purposes and also as a form of education and entertainment. It is, however, possible to use the Internet excessively, resulting in an addiction. Internet addiction can be classified as one of the so-called 'behavioral addictions', and until recently it has rarely been addressed in scientific publications. Read More

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http://dx.doi.org/10.12740/PP/82194DOI Listing
February 2019

Inhibitory control failures and blunted cortisol response to psychosocial stress in amphetamine consumers after 6 months of abstinence.

J Res Med Sci 2019 25;24:20. Epub 2019 Mar 25.

Neurosciences Department, Faculty of Health Sciences, University of Guadalajara, Mexico.

Background: Amphetamine abuse has been conceived as an addictive illness where stress regulation and inhibitory control may be crucial factors determining chronicity and relapse. Since amphetamine consumption may disrupt the cerebral systems regulating inhibition and stress behaviors, deregulation on these systems may be expected even after long-term abstinence periods. The present study aimed to evaluate the ability of abstinent amphetamine consumers to regulate stress parameters and to inhibit cognitive patterns under the acute trier social stress test (TSST) paradigm. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_1148_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450134PMC

Enhancing the Seeking Safety group intervention with trauma-sensitive yoga practice: A program evaluation.

Complement Ther Clin Pract 2019 May 13;35:308-315. Epub 2019 Mar 13.

Positive Impact Health Centers - Decatur, GA, United States. Electronic address:

Background And Purpose: The purpose of this article is to report the results of a qualitative Utilization Focused Program Evaluation on the integration of the Seeking Safety manualized group counseling intervention with Trauma-Sensitive (TS) yoga practice at a community mental health agency. To date, there has been no evaluation of Seeking Safety and TS yoga as complementary therapies.

Method And Materials: Qualitative data were generated from key informant interviews and focus groups, then coded and analyzed for theme and content. Read More

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http://dx.doi.org/10.1016/j.ctcp.2019.03.006DOI Listing

Intervention Effects of Motivation Interviewing Chinese Modified on the Mental Health of College Students with Exercise Dependence.

Psychiatr Q 2019 Apr 18. Epub 2019 Apr 18.

Physical Education Institute, Hunan First Normal University, NO.1015, The Third Fenglin Road, Changsha, 410205, China.

Exercise dependence is a psychological problem that cannot be ignored and is positively related to anxiety and depression of college students. However, only a few effective intervention methods are available to deal with exercise dependence. This study aims to investigate the intervention effects of motivation interviewing Chinese modified on the mental health of college students with exercise dependence. Read More

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http://dx.doi.org/10.1007/s11126-019-09635-2DOI Listing

Increasing the Risk of Stroke by Opium Addiction.

J Stroke Cerebrovasc Dis 2019 Apr 15. Epub 2019 Apr 15.

Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA. Electronic address:

Introduction: Stroke is among the leading causes of mortality and morbidity in the world. Besides the identified risk factor, Ischemic stroke evidence show drug use develops or exacerbates the atherosclerotic process. The current study aimed at comparing cerebrovascular ultrasounds' changes in addicted and nonaddicted people who developed ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.03.044DOI Listing

Influence of Gamma-Hydroxybutyric Acid-Use and Gamma-Hydroxybutyric Acid-Induced Coma on Affect and the Affective Network.

Eur Addict Res 2019 Apr 18:1-9. Epub 2019 Apr 18.

Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Gamma-hydroxybutyric acid (GHB) is a drug of abuse associated with increased emergency room attendances, due to GHB-induced comas. Withdrawal from GHB often increases social anxiety and is linked to alterations in emotion processing. However, little is known about the effects of GHB-use and GHB-induced comas on affect regulation in humans. Read More

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http://dx.doi.org/10.1159/000497381DOI Listing
April 2019
1 Read

Recovery dialects: A pilot study of stigmatizing and nonstigmatizing label use by individuals in recovery from substance use disorders.

Exp Clin Psychopharmacol 2019 Apr 18. Epub 2019 Apr 18.

National Institute on Drug Abuse.

Previous research has found language used to describe individuals with a substance use disorder (SUD; e.g., "addict," "substance abuser") contributes to and elicits negative bias among the general public and health care professionals. Read More

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http://dx.doi.org/10.1037/pha0000286DOI Listing

[Chronic phosphoproteomic in temporal lobe epilepsy mouse models induced by kainic acid].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):197-205

Institute of Systems Biomedicine, State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Peking University School of Pharmaceutical Science, Beijing 100191, China.

Objective: To investigate functions of proteins and signaling pathways involved in epileptogenesis during the chronic stage of temporal lobe epilepsy in mouse models.

Methods: Kainic acid-induced temporal lobe epilepsy models were conducted, when reaching stage 4 using racine scale, the mice of experimental group were supposed to be successfully established. Pentobarbital sodium was injected to stop epileptic seizure in case of death. Read More

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April 2019
3 Reads

Modulation of 'Protective' Nicotine Perception and Use Profile by Flavorants: Preliminary Findings in E-Cigarettes.

Nicotine Tob Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT.

Introduction: Characterizing flavors are widely available in e-cigarettes and motivate initiation and continued use. Flavors may enhance appeal and facilitate development of addiction to tobacco products through modulation of tobacco products' reinforcing or aversive actions. Palatable flavors (e. Read More

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http://dx.doi.org/10.1093/ntr/ntz057DOI Listing
April 2019
1 Read

A retrospective cohort study comparing non-fatal self-harm emergency department visits between Canadian veterans living in Ontario and matched civilians.

Int Rev Psychiatry 2019 Apr 17:1-9. Epub 2019 Apr 17.

d IC/ES , Toronto , Canada.

This was a retrospective cohort study linking provincial administrative databases to compare rates of non-fatal self-harm between CAF and RCMP veterans living in Ontario and age-matched civilians. This study included male veterans who registered for provincial health insurance between 2002 and 2013. A civilian comparator group was matched 4:1 on age and sex. Read More

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http://dx.doi.org/10.1080/09540261.2019.1580685DOI Listing

Initiation Sequence of E-Cigarette and Cigarette Smoking among US Adolescents: A National Study.

Am J Addict 2019 Apr 16. Epub 2019 Apr 16.

Center for the Study of Drugs, Alcohol, Smoking, and Health, Department of Health Behavior and Biological Sciences, School of Nursing, University of Michigan, Ann Arbor, Michigan.

Background And Objectives: The primary objectives were to: (1) examine the initiation sequence of e-cigarette use and cigarette smoking; (2) assess other substance use as a function of the initiation sequence of e-cigarettes and cigarettes; and (3) investigate the role of early e-cigarette initiation among US secondary school students.

Methods: Data were collected via self-administered questionnaires from independent 2015 and 2016 nationally representative cross-sectional samples of 8th grade, 10th grade, and 12th grade students (N = 36 410).

Results: The lifetime initiation sequence included: (1) e-cigarette use before cigarette smoking (1. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ajad.12886
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http://dx.doi.org/10.1111/ajad.12886DOI Listing
April 2019
6 Reads

Possible Role of Cyclic AMP Response Element Binding/Brain-Derived Neurotrophic Factor Signaling Pathway in Mediating the Pharmacological Effects of Duloxetine against Methamphetamine Use-Induced Cognitive Impairment and Withdrawal-Induced Anxiety and Depression in Rats.

Adv Biomed Res 2019 21;8:11. Epub 2019 Feb 21.

Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Duloxetine is used for treating depression and anxiety. The current study evaluated the effects of duloxetine against methamphetamine withdrawal-induced anxiety, depression, and motor disturbances and methamphetamine use-induced cognitive impairments.

Materials And Methods: Ninety-six adult male rats were used for two independent experiments. Read More

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http://dx.doi.org/10.4103/abr.abr_34_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425746PMC
February 2019

The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users.

Psychiatry Res Neuroimaging 2019 Apr 5;287:56-59. Epub 2019 Apr 5.

Addiction, Development, and Psychopathology (ADAPT) lab, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.

The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. Read More

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http://dx.doi.org/10.1016/j.pscychresns.2019.03.011DOI Listing

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala.

PLoS Biol 2019 Apr 16;17(4):e2006421. Epub 2019 Apr 16.

Neurobiology of Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America.

Oxytocin administration has been reported to decrease consumption, withdrawal, and drug-seeking associated with several drugs of abuse and thus represents a promising pharmacological approach to treat drug addiction. We used an established rat model of alcohol dependence to investigate oxytocin's effects on dependence-induced alcohol drinking, enhanced motivation for alcohol, and altered GABAergic transmission in the central nucleus of the amygdala (CeA). Intraperitoneal oxytocin administration blocked escalated alcohol drinking and the enhanced motivation for alcohol in alcohol-dependent but not nondependent rats. Read More

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http://dx.doi.org/10.1371/journal.pbio.2006421DOI Listing
April 2019
1 Read

Violence risk and mental disorders (VIORMED-2): A prospective multicenter study in Italy.

PLoS One 2019 16;14(4):e0214924. Epub 2019 Apr 16.

Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Background: The management of mentally ill offenders in the community is one of the great challenges imposed on community psychiatry.

Aim: The aim of this study was to analyze the association between sociodemographic, clinical, and psychosocial factors and violent behavior in a sample of outpatients with severe mental disorders.

Method: This was a prospective cohort study with a baseline cross-sectional design used to provide a detailed analysis of patients' profiles, followed by a longitudinal design to measure aggressive and violent behavior during a 1-year follow-up. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214924PLOS
April 2019
2 Reads
3.234 Impact Factor

The Making of an Addiction: Examining Psychological Determinants of Prescription Stimulant Abuse among College Students.

Health Commun 2019 Apr 16:1-9. Epub 2019 Apr 16.

a Department of Communication , Texas A&M University.

Diagnoses of attention-deficit-disorders and stimulant prescriptions to treat these disorders (e.g., Adderall) are on the rise. Read More

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http://dx.doi.org/10.1080/10410236.2019.1598743DOI Listing
April 2019
1 Read

Δ-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions.

Neuropharmacology 2019 Apr 11;151:127-135. Epub 2019 Apr 11.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. Electronic address:

Growing nonmedical use of prescription opioids is a global problem, motivating research on ways to reduce use and combat addiction. Medical cannabis ("medical marijuana") legalization has been associated epidemiologically with reduced opioid harms and cannabinoids have been shown to modulate effects of opioids in animal models. This study was conducted to determine if Δ-tetrahydrocannabinol (THC) enhances the behavioral effects of oxycodone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283908193012
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http://dx.doi.org/10.1016/j.neuropharm.2019.04.010DOI Listing
April 2019
3 Reads

Struggling to achieve a 'normal life': A qualitative study of Vietnamese methadone patients.

Int J Drug Policy 2019 Apr 9;68:18-26. Epub 2019 Apr 9.

Centre of Medicine, Sciences, Health, Mental Health and Health Policy (CERMES 3) (Inserm U988/CNRS UMR 8211/EHESS/Université Paris Descartes), Paris, France.

Background: Methadone maintenance treatment, initially introduced in Vietnam for HIV harm reduction, has marked a significant switch in the country's drug policy - from addiction as a moral issue to addiction as a brain disease. After the some initial outstanding achievements, the programme is facing a high dropout rate that threatens both goals of HIV prevention and drug treatment. This sociological study, as part of an HIV intervention research project, explores the challenges and opportunities that individuals who use drugs are faced with in relation to addiction treatment. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.03.026DOI Listing

Knowledge translation and implementation of housing first in Canada: A qualitative assessment of capacity building needs for an evidence-based program.

Eval Program Plann 2019 Mar 19;75:1-9. Epub 2019 Mar 19.

Centre for Addiction and Mental Health, Canada.

We examined communities' expressed needs for capacity building in the implementation of Housing First (HF) for persons experiencing homelessness. The findings are based on thematic analyses of qualitative data obtained from participants (n = 77) in 11 focus groups conducted in seven Canadian cities. We identified capacity building needs in the areas of training (e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01497189183020
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http://dx.doi.org/10.1016/j.evalprogplan.2019.03.001DOI Listing
March 2019
2 Reads

The concept of exposure when selecting comparison groups for determining individual susceptibility to addiction to cigarette smoking.

PLoS One 2019 11;14(4):e0214946. Epub 2019 Apr 11.

Graduate Program in Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.

Smoking is a leading cause of preventable death. The effect of tobacco is even more contundent in people with mental illness and, in general, cigarette smoking addiction is influenced by genetic factors. The opioid system is involved in the mesolimbic reward system, which is of great importance in addictive behaviors, such as smoking and is influenced by genes such as the OPRM1. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214946PLOS

Incentive and Dopamine Sensitization Produced by Intermittent But Not Long Access Cocaine Self-Administration.

Eur J Neurosci 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychology (Biopsychology Program), University of Michigan, Ann Arbor, MI, USA.

The temporal pattern of drug use (pharmacokinetics) has a profound effect on the ability of self-administered cocaine to produce addiction-like behavior in rodents, and to change the brain. To further address this issue, we compared the effects of Long Access (LgA) cocaine self-administration, which is widely used to model the transition to addiction, with Intermittent Access (IntA), which is thought to better reflect the pattern of drug use in humans, on the ability of a single, self-administered injection of cocaine to increase dopamine (DA) overflow in the core of the nucleus accumbens (using in vivo microdialysis), and to produce addiction-like behavior. IntA experience was more effective than LgA in producing addiction-like behavior - a drug experience-dependent increase in motivation for cocaine assessed using behavioral economic procedures, and cue-induced reinstatement - despite much less total drug consumption. Read More

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http://dx.doi.org/10.1111/ejn.14418DOI Listing

Monitoring new psychoactive substances: Exploring the contribution of an online discussion forum.

Int J Drug Policy 2019 Apr 7. Epub 2019 Apr 7.

Ecole des sciences criminelles, University of Lausanne, 1015 Lausanne, Switzerland.

Background: The rapid emergence of new psychoactive substances (NPS) is a challenge for public health authorities and law enforcement. The phenomenon is strengthened since the increase of the Internet usage. Not only used to trade NPS, the Web is an important source of information for both potential drug consumers and experienced users. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.03.025DOI Listing

Epidemiology of opioid-related visits to US Emergency Departments, 1999-2013: A retrospective study from the NHAMCS (National Hospital Ambulatory Medical Care Survey).

Am J Emerg Med 2019 Mar 31. Epub 2019 Mar 31.

Cooper Medical School of Rowan University, Department of Emergency Medicine, One Cooper Plaza, Camden, NJ, United States of America.

Goals: To characterize the epidemiology of opioid-related visits to United States (US) emergency departments (EDs) and describe trends in opioid-related visits over time.

Design: Retrospective cohort study CASES: The National Hospital Ambulatory Care Survey (NHAMCS) was used to identify opioid-related ED visits between 1999 and 2013.

Measurements: The NHAMCS is an annual, weighted, multi-stage survey which allows for the study of ambulatory care services within a nationally representative sample of US hospitals. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.03.052DOI Listing
March 2019
4 Reads

"The Time Has Arrived": Perceptions of Behavioral Adjustments in the Context of Pre-Exposure Prophylaxis Availability Among Adolescents in South Africa.

AIDS Educ Prev 2018 Dec;30(6):463-473

Department of Behavioral and Social Sciences, Brown University School of Public Health.

Antiretroviral pre-exposure prophylaxis (PrEP) holds enormous potential to reduce HIV acquisition in key populations globally. We conducted an exploratory PrEP acceptability study using qualitative methodology among adolescents and service providers in the Western Cape Province of South Africa to inform future PrEP implementation challenges in South Africa and other high-prevalence African countries. Semistructured focus groups and in-depth individual interviews were conducted among 57 adolescents 16-17 years of age, living with and without HIV, and 25 clinical service providers. Read More

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http://dx.doi.org/10.1521/aeap.2018.30.6.463DOI Listing
December 2018

A strengths-based case management intervention to link HIV-positive PWID in Russia to HIV care - results from a randomized controlled trial.

AIDS 2019 Apr 5. Epub 2019 Apr 5.

First Pavlov State Medical University of St. Petersburg, Lev Tolstoy St. 6/8, St. Petersburg 197022, Russian Federation.

Objective: To determine whether the LINC strengths-based case management intervention was more effective than usual care for linking people who inject drugs (PWID) to HIV care and improving HIV outcomes.

Design: Two-armed randomized controlled trial.

Setting: Participants recruited from a narcology hospital in St. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002230DOI Listing
April 2019
1 Read
5.554 Impact Factor

Differential levels of prefrontal cortex glutamate+glutamine in adults with antisocial personality disorder and bipolar disorder: A proton magnetic resonance spectroscopy study.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Apr 5. Epub 2019 Apr 5.

Research Imaging Centre, Campbell Family Mental Health Research Institute and Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Violence Prevention Neurobiological Research Unit, Forensic Psychiatry, CAMH, Toronto, ON, Canada; Faculty of Medicine Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Faculty of Arts and Science, Department of Criminology and Sociological Studies, University of Toronto, Toronto, ON, Canada; Waypoint Centre for Mental Health Care, Penetanguishene, ON, Canada. Electronic address:

As the main excitatory neurotransmitter in the central nervous system, glutamate, as measured in combination with glutamine (Glx), is implicated in several psychopathologies when levels are aberrant. One illness that shows heightened Glx levels is bipolar disorder (BD), an illness characterized by high impulsivity. In addition, although animal studies have reported elevated levels of Glx in aggressive and impulsive phenotypes, no study, to our knowledge, has reported Glx in the human cortex in relation to aggression. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.04.002DOI Listing
April 2019
1 Read

The training game SALIENCE for the therapy of alcohol use disorder.

Health Informatics J 2019 Apr 8:1460458219839612. Epub 2019 Apr 8.

University of Mannheim, Germany.

The feasibility study was aimed to develop a web-based gaming tool for the therapy of alcohol use disorder to offer patients a cue-exposure-based extinction and decision training, enhanced with virtual reality. To increase the training effect, patients playfully experience situations that resemble critical real-life situations. For implementing the game, a combination of HTML5 and JavaScript was used. Read More

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http://dx.doi.org/10.1177/1460458219839612DOI Listing
April 2019
2 Reads

Structural brain characteristics of anabolic-androgenic steroid dependence in men.

Addiction 2019 Apr 7. Epub 2019 Apr 7.

The Anabolic Androgenic Steroid Research Group, National Advisory Unit on Substance Use Disorder Treatment, the Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Aim: To identify differences in brain morphology between dependent and non-dependent male anabolic-androgenic steroid (AAS) users.

Design: Cross-sectional data from a longitudinal study on male weightlifters.

Setting: Oslo University Hospital, Norway. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/add.14629
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http://dx.doi.org/10.1111/add.14629DOI Listing
April 2019
1 Read

Exploring the interoceptive stimulus effects of nicotine and varenicline.

Pharmacol Biochem Behav 2019 Apr 4;181:9-16. Epub 2019 Apr 4.

Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA. Electronic address:

Learning processes associated with nicotine influence the development of addiction to tobacco products. In the present report, we are interested in the interoceptive stimulus effects of nicotine acquiring control over appetitive behaviors - specifically, reward seeking. Also of interest is the current smoking cessation drug, varenicline (Chantix®). Read More

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http://dx.doi.org/10.1016/j.pbb.2019.04.001DOI Listing
April 2019
2 Reads

How to determine whether conceptual endophenotypes can improve clinical outcomes in patients suffering from major depression: An exploratory approach.

Psychoneuroendocrinology 2019 Mar 15. Epub 2019 Mar 15.

Department of Psychology, Division of Clinical and Physiological Psychology, Trier University, Johanniterufer 15, D-54290 Trier, Germany.

Depression is a complex mental health disorder, resulting in a high degree of disability. Since symptom constellation, course, and outcome are heterogeneous in these patients, current research initiatives are striving to establish stratified diagnostic and treatment approaches. In the past two decades, Dirk Hellhammer and his team introduced Neuropattern, a new diagnostic concept, which is based on conceptual endophenotypes of the stress response network. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.03.010DOI Listing
March 2019
1 Read

Melatonin Pretreatment Attenuates Acute Methamphetamine-induced Aggression in Male ICR Mice.

Brain Res 2019 Apr 3. Epub 2019 Apr 3.

Department of Epidemiology & Health Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan 430030, China. Electronic address:

Aggression is one of the symptoms of methamphetamine (MA) use and withdrawal, which can exacerbate MA addiction and relapse. Many studies have demonstrated that poor sleep is significantly associated with aggression. Melatonin has been indicated to be effective in treating sleep disorders induced by MA, and it can also protect neuronal cells against MA-induced neurotoxicity. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.002DOI Listing
April 2019
2 Reads

High-Cost Hospitalizations Among Elderly Patients With Cancer.

J Oncol Pract 2019 Apr 4:JOP1800706. Epub 2019 Apr 4.

1 University of Texas Medical Branch, Galveston, TX.

Purpose:: Health care costs are driven by a small proportion of patients, and it is important to identify their characteristics to effectively manage their health care needs. We examined characteristics associated with high-cost inpatient visits of elderly patients with cancer using a national sample.

Methods:: We identified 574,367 inpatient visits of individuals age 65 years or older with a cancer diagnosis using the 2014 National Inpatient Sample data, an all-payer sample of inpatient stays in the United States. Read More

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http://dx.doi.org/10.1200/JOP.18.00706DOI Listing
April 2019
1 Read

Differences in the rate of nicotine metabolism among smokers with and without HIV.

AIDS 2019 May;33(6):1083-1088

Department of Psychiatry, University of Pennsylvania Perelman School of Medicine.

Objective: HIV-infected smokers lose more life years to tobacco use than to HIV infection. The nicotine metabolite ratio (NMR), a biomarker of CYP2A6, represents individual variation in the rate at which nicotine is metabolized and is associated with response to smoking cessation treatments. We evaluated whether HIV-infected smokers metabolize nicotine faster than HIV-uninfected smokers, which may contribute to the disproportionate smoking burden and may have important treatment implications. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457129PMC
May 2019
3 Reads

A short history of individual placement and support in Norway.

Psychiatr Rehabil J 2019 Apr 4. Epub 2019 Apr 4.

Department of Research and Section of Early Psychosis Treatment, Division of Mental Health and Addiction, Oslo University Hospital.

Objective: Norway is a high-income and high-cost society with a generous welfare system, and it has the largest mental health-related unemployment gap of the OECD countries. The aim of the current article was to present a short history of Individual Placement and Support (IPS) services to increase work participation in Norway.

Method: We provide a narrative overview of the developments and research on IPS in Norway, from the introduction of supported employment to recent and ongoing randomized controlled trials (RCTs) investigating the effectiveness of IPS for various target groups. Read More

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http://dx.doi.org/10.1037/prj0000366DOI Listing
April 2019
3 Reads

Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence.

JAMA Psychiatry 2019 Apr 3. Epub 2019 Apr 3.

Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández de Elche, Sant Joan d'Alacant, Alicante, Spain.

Importance: Although the detrimental effects of alcohol on the brain are widely acknowledged, observed structural changes are highly heterogeneous, and diagnostic markers for characterizing alcohol-induced brain damage, especially in early abstinence, are lacking. This heterogeneity, likely contributed to by comorbidity factors in patients with alcohol use disorder (AUD), challenges a direct link of brain alterations to the pathophysiology of alcohol misuse. Translational studies in animal models may help bridge this causal gap. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0318DOI Listing

Metabolomic study of polyamines in rat urine following intraperitoneal injection of γ-hydroxybutyric acid.

Metabolomics 2019 Apr 2;15(4):58. Epub 2019 Apr 2.

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, 540-950, Republic of Korea.

Introduction: Recently, illegal abuse of γ-hydroxybutyric acid (GHB) has increased in drug-facilitated crimes, but the determination of GHB exposure and intoxication is difficult due to rapid metabolism of GHB. Its biochemical mechanism has not been completely investigated. And a metabolomic study by polyamine profile and pattern analyses was not performed in rat urine following intraperitoneal injection with GHB. Read More

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http://dx.doi.org/10.1007/s11306-019-1517-2DOI Listing

Cross-cultural Applicability of the 12-Step Model: A Comparison of Narcotics Anonymous in the USA and Iran.

J Addict Med 2019 Apr 1. Epub 2019 Apr 1.

Department of Psychiatry, New York University School of Medicine, New York, NY (MG); and Chestnut Health Systems, Normal, IL (WLM, BDH).

Objective: Narcotics Anonymous (NA), a nonprofessional 12-step fellowship for people seeking recovery from addiction, reports 27,677 meetings in the USA, where it was founded, but there is limited literature on its adaptability cross-culturally. We studied NA within the Islamic Republic of Iran to ascertain its relative adaptation in a different cultural setting.

Method: We surveyed 262 NA members in Iran, supplemented by member interviews, and compared demographic and substance use-related characteristics of members, and also the nature of their respective involvement in NA, to the survey results of a previous US survey (n = 527). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000526DOI Listing
April 2019
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To Each Stress Its Own Screen: A Cross-Sectional Survey of the Patterns of Stress and Various Screen Uses in Relation to Self-Admitted Screen Addiction.

J Med Internet Res 2019 Apr 2;21(4):e11485. Epub 2019 Apr 2.

PERFORM Centre, Department of Mathematics and Statistics, Concordia University, Montreal, QC, Canada.

Background: The relationship between stress and screen addiction is often studied by exploring a single aspect of screen-related behavior in terms of maladaptive dependency or the risks associated with the content. Generally, little attention is given to the pattern of using different screens for different types of stressors, and variations arising from the subjective perception of stress and screen addiction are often neglected. Given that both addiction and stress are complex and multidimensional factors, we performed a multivariate analysis of the link between individual's subjective perceptions of screen addiction, various types of stress, and the pattern of screen usage. Read More

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http://dx.doi.org/10.2196/11485DOI Listing
April 2019
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Brain activity associated with social exclusion overlaps with drug-related frontal-striatal circuitry in cocaine users: A pilot study.

Neurobiol Stress 2019 Feb 30;10:100137. Epub 2018 Oct 30.

Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.

Background: Exposure to various types of stress can elevate craving for cocaine and hasten relapse among substance dependent individuals. This investigation evaluated the effects of social exclusion on brain activity in cocaine dependent individuals.

Method: Forty three individuals (18 crack-cocaine users, 25 controls) were recruited from the community to participate in functional neuroimaging study in which they performed a simulated 3 person ball-tossing game (Cyberball). Read More

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http://dx.doi.org/10.1016/j.ynstr.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430184PMC
February 2019
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COPE.er Method: Combating Digital Addiction via Online Peer Support Groups.

Int J Environ Res Public Health 2019 Mar 31;16(7). Epub 2019 Mar 31.

Faculty of Science and Technology, Bournemouth University, Fern Barrow, Poole BH12 5BB, UK.

Digital addiction (hereafter DA) denotes a problematic relationship with technology described by being compulsive, obsessive, impulsive and hasty. New research has identified cases where users' digital behaviour shows symptoms meeting the clinical criteria of behavioural addiction. The online peer groups approach is one of the strategies to combat addictive behaviours. Read More

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http://dx.doi.org/10.3390/ijerph16071162DOI Listing

Screen of drug use: Diagnostic accuracy for cannabis use disorder.

Addict Behav 2019 Feb 11;95:184-188. Epub 2019 Feb 11.

Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United States of America.

Objective: As cannabis has been legalized for medicinal and recreational use, rates of cannabis misuse and cannabis use disorder (CUD) have increased. However, only a small percentage of individuals with CUD seek treatment. A practical screening instrument is needed to detect CUD in primary care (PC) to address the needs of individuals with CUD. Read More

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http://dx.doi.org/10.1016/j.addbeh.2019.02.010DOI Listing
February 2019

Spanish validation of the pathological buying screener in patients with eating disorder and gambling disorder.

J Behav Addict 2019 Mar;8(1):123-134

1 Department of Psychiatry, Bellvitge University Hospital-IDIBELL , Barcelona, Spain.

Background And Aims: Pathological buying (PB) is a behavioral addiction that presents comorbidity with several psychiatric disorders. Despite the increase in the prevalence estimates of PB, relatively few PB instruments have been developed. Our aim was to assess the psychometric properties of the Spanish version of the pathological buying screener (PBS) and to explore the associations between PB, psychopathology, and personality traits. Read More

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http://dx.doi.org/10.1556/2006.8.2019.08DOI Listing
March 2019
2 Reads

Living With Dual Diagnosis and Homelessness: Marginalized Within a Marginalized Group.

J Dual Diagn 2019 Mar 31:1-7. Epub 2019 Mar 31.

a Centre for Health Evaluation and Outcome Sciences , St. Paul's Hospital , Vancouver , Canada.

Objective: Concurrent mental and substance use disorders or dual diagnosis are highly prevalent among individuals experiencing homelessness. Studies have indicated that dual diagnosis leads to poorer health outcomes and higher health service utilization among those affected. This study aims to estimate the prevalence of dual diagnoses among homeless populations in British Columbia (BC), Canada, and understand their characteristics and specific factors associated with dual diagnoses. Read More

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http://dx.doi.org/10.1080/15504263.2019.1579948DOI Listing

Intact responses to non-drug rewards in long-term opioid maintenance treatment.

Neuropsychopharmacology 2019 Mar 31. Epub 2019 Mar 31.

Norwegian Centre for Addiction Research (SERAF), Faculty of Medicine, University of Oslo, Oslo, Norway.

Disruption of non-drug reward processing in addiction could stem from long-term drug use, addiction-related psychosocial stress, or a combination of these. It remains unclear whether long-term opioid maintenance treatment (OMT) disrupts reward processing. Here, we measured subjective and objective reward responsiveness in 26 previously heroin-addicted mothers in >7 years stable OMT with minimal psychosocial stress and illicit drug use. Read More

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http://dx.doi.org/10.1038/s41386-019-0377-9DOI Listing
March 2019
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The polymorphism of dopamine D2 receptor TaqIA gene is associated with brain response to drug cues in male heroin-dependent individuals during methadone maintenance treatment.

Drug Alcohol Depend 2019 May 28;198:150-157. Epub 2019 Feb 28.

Department of Radiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an, 569 Xinsi Road, Baqiao District, China. Electronic address:

Background: Polymorphism of the dopamine D2 receptor TaqIA gene is related to reward response, relapse risks and effect of therapy for drug addiction. Whether the cue-induced craving and brain response was related to dopamine D2 receptor TaqIA gene is unknown.

Methods: Forty-nine male heroin-dependent individuals [31 with A1 allele of the TaqIA (A1+), 18 A2 allele carriers (A1-)] under methadone maintenance treatment and 20 healthy control subjects performed a heroin cue-reactivity task during functional magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.01.028DOI Listing
May 2019
4 Reads
3.423 Impact Factor

Berberine hydrochloride attenuates voluntary methamphetamine consumption and anxiety-like behaviors via modulation of oxytocin receptors in methamphetamine addicted rats.

Physiol Behav 2019 Mar 25;206:157-165. Epub 2019 Mar 25.

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Objective: Methamphetamine (METH) addiction is recognized as one of the major public health concerns, with no approved pharmacological agents for treatment. Berberine hydrochloride, an isoquinoline alkaloid in plants, induces antipsychotic and anxiolytic effects. Hence, we hypothesized that berberine may modulate the METH-induced rewarding effects. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.03.024DOI Listing

Cocreative Development of the QoL-ME: A Visual and Personalized Quality of Life Assessment App for People With Severe Mental Health Problems.

JMIR Ment Health 2019 Mar 28;6(3):e12378. Epub 2019 Mar 28.

Scientific Center for Care and Wellbeing (Tranzo), Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, Netherlands.

Background: Quality of life (QoL) is a prominent outcome measure in mental health. However, conventional methods for QoL assessment rely heavily on language-based communication and therefore may not be optimal for all individuals with severe mental health problems. In addition, QoL assessment is usually based on a fixed number of life domains. Read More

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http://dx.doi.org/10.2196/12378DOI Listing
March 2019
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