1,180 results match your criteria Journal of Gastrointestinal Cancer [Journal]


Computerized Tomography Criteria as a Tool for Simplifying the Assessment of Locally Advanced Rectal Cancer.

J Gastrointest Cancer 2019 Mar 11. Epub 2019 Mar 11.

Gastroenterology Department, Hillel Yaffe Medical Center, Hashalom Street, Hadera, Israel.

Background: Rectal cancer represents a leading cause of mortality worldwide. Staging defines the local and distant extent of the disease, guides management, and predicts prognosis. Different modalities are available for staging including TRUS (transrectal ultrasound), CT (computed tomography), and MRI (magnetic resonance imaging). Read More

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http://dx.doi.org/10.1007/s12029-019-00220-1DOI Listing

Histopathological Examination of Gallbladder Specimens in Kumaon Region of Uttarakhand.

J Gastrointest Cancer 2019 Mar 8. Epub 2019 Mar 8.

Department of Surgery, Government Medical College, Haldwani, Nainital, Uttarakhand, 263139, India.

Gall stones are one of the major causes of morbidity and mortality all over the world and common health problems throughout in developing countries. Cholecystectomy is one of the most common surgical practices and postoperative analysis of cholecystectomy specimen has a great value since histopathological reports may document some entities with significant clinical significances. Gallbladder carcinomas in cholecystectomy specimens are received in our histopathology laboratory to analyse their clinicopathological features. Read More

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http://dx.doi.org/10.1007/s12029-018-00188-4DOI Listing
March 2019
1 Read

Colon Adenocarcinoma Stage IIA-Can We Predict Relapse?

J Gastrointest Cancer 2019 Mar 4. Epub 2019 Mar 4.

Serviço de Gastrenterologia, Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG) EPE, 1099-023, Lisbon, Portugal.

Purpose: To determine prognostic factors for stage IIA colon cancer (CC) recurrence in patients undergoing curative intent surgery without adjuvant treatment.

Methods: Single-centre cohort study. All patients with stage IIA CC discussed in a multidisciplinary colorectal cancer clinic from January 2010 to December 2012 were evaluated. Read More

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http://dx.doi.org/10.1007/s12029-019-00218-9DOI Listing
March 2019
3 Reads

Multiple Small Bowel Perforations Secondary to Tumor Lysis-a Complication of Pseudomyxoma Peritonei in a Patient Undergoing Intraperitoneal Chemotherapy.

J Gastrointest Cancer 2019 Feb 28. Epub 2019 Feb 28.

The Queen Elizabeth Hospital, 28 Woodville Rd, Woodville South, SA, 5011, Australia.

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http://dx.doi.org/10.1007/s12029-019-00216-xDOI Listing
February 2019

LNA Inhibitor in microRNA miR-23b as a Potential Anti-proliferative Option in Human Hepatocellular Carcinoma.

J Gastrointest Cancer 2019 Feb 28. Epub 2019 Feb 28.

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Purpose: Dysregulation of microRNAs (miRNAs) has been shown to be involved in the pathogenesis and progression of many malignancies. Human hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the third cause of cancer-related deaths. Recent data suggest that microRNA-23b (miR-23b) is significantly high in different types of cancer, specifically human hepatocellular carcinoma. Read More

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http://dx.doi.org/10.1007/s12029-019-00215-yDOI Listing
February 2019
1 Read

Sentinel Node Navigation in Gastric Cancer: Where Do We Stand?

J Gastrointest Cancer 2019 Feb 28. Epub 2019 Feb 28.

Department of Surgery, ASST Valle Olona, Gallarate, Italy.

Background: Early gastric cancer (EGC) is more common nowadays and is related a to low percentage of lymph node metastasis. For this reason, there is enormous interest to implicate minimally invasive approaches. Recently, special efforts have been made towards a potential intraoperative (real-time) lymph node metastasis (LNM) assessment, as nodal disease status could not be identified with precision before or during surgery. Read More

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http://dx.doi.org/10.1007/s12029-019-00217-wDOI Listing
February 2019
1 Read

Dilemmas in Diagnosis and Management of Gastroenteropancreatic Mixed Neuroendocrine Non-neuroendocrine Neoplasms: First Single-Centre Report from India.

J Gastrointest Cancer 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgical Oncology, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, 400050, India.

Purpose: Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is a rare neoplasm comprising of exocrine and neuroendocrine elements, each representing ≥ 30% lesion. It is commonly misdiagnosed as adenocarcinoma or grade-3 neuroendocrine neoplasm (NEN). Management is not well-defined. Read More

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http://dx.doi.org/10.1007/s12029-019-00213-0DOI Listing
February 2019
1 Read

The Diagnostic Value of Arginase-1, FTCD, and MOC-31 Expression in Early Detection of Hepatocellular Carcinoma (HCC) and in Differentiation Between HCC and Metastatic Adenocarcinoma to the Liver.

J Gastrointest Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Medical Oncology, Faculty of Medicine, Zagazig University Zagazig, Zagazig, Egypt.

Background: Early detection of small HCC and differentiation between HCC from AC metastatic to the liver is very essential for surgical pathologists, due to different treatment modalities. Immunohistochemistry plays a very important role in such conditions. In our study, we aimed to identify the diagnostic benefits of Arginase-1, FTCD& MOC-31 in the early detection of HCC in normal or cirrhotic liver, differentiation between HCC and metastatic ACs to the liver, and for early detection of small micro-metastases from ACs to liver. Read More

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http://dx.doi.org/10.1007/s12029-019-00211-2DOI Listing
February 2019
1 Read

Unexpected Prolonged Survival After Extended and Emergent Resection of Pancreatic Metastases from Renal Cell Carcinoma.

J Gastrointest Cancer 2019 Feb 15. Epub 2019 Feb 15.

Policlinico Umberto I, University "La Sapienza", Rome, Italy.

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http://link.springer.com/10.1007/s12029-019-00209-w
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http://dx.doi.org/10.1007/s12029-019-00209-wDOI Listing
February 2019
2 Reads

Monomorphic Epitheliotropic Intestinal T cell Lymphoma: a Rare Cause of Chronic Diarrhea.

J Gastrointest Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology and Hepatology, The University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555-0570, USA.

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http://dx.doi.org/10.1007/s12029-019-00210-3DOI Listing
February 2019

Role of DIDO1 in Progression of Esophageal Squamous Cell Carcinoma.

J Gastrointest Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: Apoptosis is one of the main involved processes during development and organogenesis and its aberration may result in tumorigenesis. In the present study, due to the role of death inducer-obliterator 1 (DIDO1) in activation of caspases 9 and 3 during the apoptosis process, the role of DIDO1 as the shortest splicing variant of the DIDO gene was assessed for the first time in esophageal squamous cell carcinoma (ESCC) patients.

Methods: DIDO1 mRNA expression in tumor tissues from 50 ESCC patients was compared to their corresponding margin normal tissues using the real-time polymerase chain reaction (RT-PCR). Read More

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http://link.springer.com/10.1007/s12029-019-00212-1
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http://dx.doi.org/10.1007/s12029-019-00212-1DOI Listing
February 2019
5 Reads

A Case Report of a Primary Neuroendocrine Tumour of the Proximal Common Bile Duct.

J Gastrointest Cancer 2019 Feb 9. Epub 2019 Feb 9.

Department of surgery B, Charles Nicolle Hospital, Tunis, Tunisia.

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http://dx.doi.org/10.1007/s12029-019-00208-xDOI Listing
February 2019

The Incidence of Hepatocellular Carcinoma in Iran from 1996 to 2016: a Systematic Review and Meta-analysis.

J Gastrointest Cancer 2019 Feb 6. Epub 2019 Feb 6.

Iranian Center of Excellence in Health Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: Hepatocellular carcinoma or liver cancer (LC) is one of most important cancer around the world. There are several reports about LC incidence from various Iranian locations with conflicting results. The present study aimed to accomplish a systematic review to estimate the accurate incidence rate of LC among Iranian people. Read More

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http://dx.doi.org/10.1007/s12029-019-00207-yDOI Listing
February 2019
1 Read

Curcumin and Gastric Cancer: a Review on Mechanisms of Action.

J Gastrointest Cancer 2019 Feb 6. Epub 2019 Feb 6.

Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, IR, Iran.

Background And Aim: Gastric cancer, as the fourth cause of death in women and third in men with malignant tumors, is now threatening people's lives worldwide. Natural anti-tumor products are potential anti-cancer agents with fewer by-effects. Curcumin, an herbal product, has been used as a cosmetic and food additive and as a traditional herbal medicine for thousands of years in Asian countries. Read More

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http://link.springer.com/10.1007/s12029-018-00186-6
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http://dx.doi.org/10.1007/s12029-018-00186-6DOI Listing
February 2019
5 Reads

Undifferentiated Embryonal Sarcoma of the Liver: a Great Masquerader.

J Gastrointest Cancer 2019 Feb 4. Epub 2019 Feb 4.

Division of Transplant Hepatology, NYU Langone Medical Center, New York City, NY, USA.

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http://dx.doi.org/10.1007/s12029-018-00194-6DOI Listing
February 2019

Assessment of Relationship Between Expression of Survivin Protein and Histopathology Diagnosis and Malignancy Severity in Colon Specimen.

J Gastrointest Cancer 2019 Feb 4. Epub 2019 Feb 4.

Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Background: Survivin is a member of the inhibitor of an apoptosis protein family that has been shown to inhibit apoptosis, promote cell proliferation and enhance angiogenesis. In this study, the survivin protein expression in normal, colon polyp, and adenocarcinoma tissues was investigated.

Methods: Immunohistochemical staining for nuclear survivin was carried out on 45 normal colon tissue samples, 38 samples of a colonic polyp, and 37 cases of colon adenocarcinoma operated by colonoscopy or colectomy. Read More

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http://dx.doi.org/10.1007/s12029-019-00206-zDOI Listing
February 2019
3 Reads

Synergistic Beneficial Effect of Docosahexaenoic Acid (DHA) and Docetaxel on the Expression Level of Matrix Metalloproteinase-2 (MMP-2) and MicroRNA-106b in Gastric Cancer.

J Gastrointest Cancer 2019 Jan 24. Epub 2019 Jan 24.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Gastric cancer (GC) is one of the most common cancers with the majority of patients recognized in advanced stages. The efficacy of using docosahexaenoic acid (DHA) as a supplementary agent has been suggested in treatment along with chemotherapeutics including docetaxel. However, the molecular signatures of such beneficial effects are not well-understood. Read More

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http://link.springer.com/10.1007/s12029-019-00205-0
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http://dx.doi.org/10.1007/s12029-019-00205-0DOI Listing
January 2019
14 Reads

Trends in Mortality Rates for Gastrointestinal Cancers in Fars Province, Iran (2005-2015).

J Gastrointest Cancer 2019 Jan 21. Epub 2019 Jan 21.

Non-communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: In Iran, cancers are the third leading cause of death, and gastrointestinal cancers are the primary cause of mortality among all the cancers. This study aimed to determine the trend of crude and age-standardized mortality rates (ASMR) for different types of gastrointestinal cancers over an 11-year period in Fars province (Iran).

Methods: In this study, all the mortality data for gastrointestinal cancers were derived from the Electronic Death Registration System (EDRS) between 2005 and 2015. Read More

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http://dx.doi.org/10.1007/s12029-019-00204-1DOI Listing
January 2019
3 Reads

Prognostic Value of BRAF and KRAS Mutation in Relation to Colorectal Cancer Survival in Iranian Patients: Correlated to Microsatellite Instability.

J Gastrointest Cancer 2019 Jan 12. Epub 2019 Jan 12.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Erabi Ave, P.O. Box 1985717413, Tehran, Velenjak, Iran.

Purpose: To evaluate the prognostic role of BRAF and KRAS mutations after adjustment for microsatellite instability (MSI) in Iranian colorectal cancer (CRC) patients.

Methods: BRAF and KRAS mutations and MSI status were assessed in 258 Iranian subjects with CRC. Two hundred fifty-eight consecutive stages I-IV CRC patients, who underwent surgical resection of adenocarcinoma from 2012 to 2016, were enrolled in the research. Read More

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http://dx.doi.org/10.1007/s12029-019-00201-4DOI Listing
January 2019
3 Reads

Music Is Capable of Inducing Changes in Gene Expression in Gastric Cancer Cells.

J Gastrointest Cancer 2019 Mar;50(1):175-180

Laboratory of Molecular and Cellular Biology of Cancer, Department of Biomedical Sciences, Faculty of Medicine, Universidad Católica del Norte, Coquimbo, Chile.

Purpose: Music has recognized beneficial effects on cancer patients; however, very little is known about the molecular processes which produce these benefits. The aim of this work was to evaluate the effect of music on proliferation and gene expression in gastric cancer cells.

Methods: AGS gastric cancer cells were exposed to metal and classical music, and subsequently cell proliferation and expression of genes associated with apoptosis and cell-cycle control were evaluated. Read More

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http://dx.doi.org/10.1007/s12029-019-00203-2DOI Listing
March 2019
1 Read

Underlying Colorectal Cancer Was Rarely Detected After an Episode of Acute Diverticulitis: a Retrospective Analysis of 225 Patients.

J Gastrointest Cancer 2019 Jan 10. Epub 2019 Jan 10.

Gastroenterology and endoscopy united, The Nazareth Hospital, EMMS, Nazareth, Israel.

Purpose: The aim of the present study was to determine the prevalence of underlying colorectal carcinoma (CRC) in a cohort of patients who experienced an episode of acute diverticulitis and to assess clinical and laboratory parameters that suggest CRC diagnosis.

Methods: We performed a single center retrospective study in EMMS Nazareth Hospital from April 2014 to April 2018. All Patients who experienced an episode of acute diverticulitis and underwent a colonoscopy up to 6-month period were included in the study. Read More

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http://link.springer.com/10.1007/s12029-019-00202-3
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http://dx.doi.org/10.1007/s12029-019-00202-3DOI Listing
January 2019
8 Reads

Therapeutic Challenges in the Management of Bleeding Duodenal Gastrointestinal Stromal Tumor: a Case Report and Review of Literature.

J Gastrointest Cancer 2019 Mar;50(1):170-174

Department of Pathology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.

Introduction: Duodenum is an uncommon site for the gastrointestinal stromal tumors (GISTs). Though the principles of management are the same of that elsewhere in the gastrointestinal tract, the anatomical complexity poses challenges in deciding the most appropriate treatment. A bleeding GIST further compounds the difficulty in managing such patients. Read More

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http://dx.doi.org/10.1007/s12029-018-00197-3DOI Listing
March 2019
2 Reads

Association of High Expression Levels of SOX2, NANOG, and OCT4 in Gastric Cancer Tumor Tissues with Progression and Poor Prognosis.

J Gastrointest Cancer 2019 Jan 9. Epub 2019 Jan 9.

Iran National Tumor Bank, Cancer Biology Research Center, Cancer Institute of Iran., Tehran University of Medical Sciences, Keshavarz Boulevard, Tehran, Iran.

Background: Expression of the essential regulator genes, SOX2, NANOG, and OCT4, so-called as stemness factors, is prerequisite for the tumorigenic capability of cancer stem cells (CSCs) and their potential role in the formation and progression of various human cancers.

Methods: In this study, the expression levels of SOX2, NANOG, and OCT4 were quantified by a qRT-PCR method in 100 gastric cancer tumor tissues vs the paired adjacent normal tissues. Then, the relationship between the expression of the three genes in gastric cancer tumor tissues and the clinicopathological characteristics and overall survival of patients was investigated. Read More

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http://dx.doi.org/10.1007/s12029-018-00200-xDOI Listing
January 2019
2 Reads

Outcome Determining Factors of Intraductal Papillary Neoplasm of the Biliary Tract (IPNB)-a Single Center Survey and Analysis of Current Literature.

J Gastrointest Cancer 2019 Mar;50(1):160-169

Department of Surgery, St. Josef-Hospital, Ruhr-University, Gudrunstrasse 56, 44791, Bochum, Germany.

Purpose: Intraductal papillary neoplasms of the biliary tract (IPNB) are rare tumors originating from the bile duct epithelium. Metastatic disease of IPNB is extremely rare and only reported in a small number of cases worldwide. Due to this limitation in number, the treatment of IPNB mainly relies on retrospective case series. Read More

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http://dx.doi.org/10.1007/s12029-018-00199-1DOI Listing
March 2019
4 Reads

Long-Term Outcomes After Hepatic and Pancreatic Resections for Metastases from Thyroid Cancer: a Systematic Review of the Literature.

J Gastrointest Cancer 2019 Mar;50(1):9-15

3rd Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Rimini 1, 12462, Chaidari, Greece.

Purpose: The objective of our systematic review was to evaluate the long-term outcomes of surgical resection as a treatment strategy for liver and pancreatic metastases from thyroid cancer (TC).

Methods: A systematic search of three electronic databases for articles published up to October 2018 was conducted. All appropriate observational studies and case reports which reported outcomes from patients with TC metastatic to the liver or pancreas were considered eligible for inclusion in the present systematic review. Read More

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http://dx.doi.org/10.1007/s12029-018-00196-4DOI Listing
March 2019
2 Reads

Pseudomyxoma Peritonei: Case Report and Literature Review.

J Gastrointest Cancer 2019 Jan 8. Epub 2019 Jan 8.

Department of Oncology, San Juan Bautista School of Medicine, Caguas, PR, USA.

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http://dx.doi.org/10.1007/s12029-018-00192-8DOI Listing
January 2019
4 Reads

BRAF V600E Expression by Immunohistochemistry in Colon Cancer and Clinico-pathologic Features Associated with BRAF-Mutated Colonic Cancers in Mexican Patients.

J Gastrointest Cancer 2019 Jan 8. Epub 2019 Jan 8.

Surgical Oncology, Hospital Ángeles Tijuana, Tijuana, Baja California Norte, Mexico.

Background: BRAF evaluation is currently limited to molecular techniques, which are expensive and not widely available to practicing pathologists. Our objective was to determine the diagnostic performance of immunohistochemistry (IHC) against BRAF V600E for BRAF mutation and the secondary objective was determining histopathological characteristics of colon carcinomas with BRAF mutated.

Methods: Cases of adenocarcinoma of the colon with a known BRAF mutation status were identified from the pathological files of our institution. Read More

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http://link.springer.com/10.1007/s12029-018-00191-9
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http://dx.doi.org/10.1007/s12029-018-00191-9DOI Listing
January 2019
11 Reads

Extranodal Marginal Zone B Cell (MALT) Lymphoma of the Esophagus.

J Gastrointest Cancer 2019 Jan 8. Epub 2019 Jan 8.

Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s12029-018-00187-5DOI Listing
January 2019
2 Reads

Late-Onset Lung Metastasis in Rectum Cancer Can Be Confused with Primary Lung Cancer; a Case Report and Literature Review.

J Gastrointest Cancer 2019 Jan 6. Epub 2019 Jan 6.

Department of Pathology, Trakya University Faculty of Medicine, Edirne, Turkey.

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http://dx.doi.org/10.1007/s12029-018-00190-wDOI Listing
January 2019
2 Reads

Influence of Treatment Caused Impairments on Anxiety and Depression in Patients with Cancer of the Esophagus or the Esophagogastric Junction.

J Gastrointest Cancer 2019 Jan 6. Epub 2019 Jan 6.

Department of Dermatology, University Medicine Greifswald, Greifswald, Germany.

Purpose: After therapy of cancer of the esophagus or the esophagogastric junction, patients often suffer from anxiety and depression. Some risk factors for elevated anxiety and depression are reported, but the influence of steatorrhea, the frequency of which has only recently been reported, has not yet been investigated.

Method: Using the Hospital Anxiety and Depression Scale (HADS), we analyzed the correlation of anxiety and depression with steatorrhea, appetite, and weight loss in 72 patients with cancer of the esophagus or of the esophagogastric junction, who were treated at our rehabilitation clinic between January 2011 and December 2014. Read More

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http://dx.doi.org/10.1007/s12029-018-00193-7DOI Listing
January 2019
2 Reads

A Giant Anorectal Condyloma Is Not Synonym of Malignancy.

J Gastrointest Cancer 2019 Jan 6. Epub 2019 Jan 6.

University of Tunis El Manar, Faculty of Medicine of Tunis, Department « B » of General Surgery, Charles Nicolle Hospital, Tunis, Tunisia.

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http://dx.doi.org/10.1007/s12029-018-00189-3DOI Listing
January 2019
2 Reads

Bile Duct Hamartoma Mimicking Liver Metastasis in Suspected Porcelain Gallbladder: a Case Report.

J Gastrointest Cancer 2019 Jan 6. Epub 2019 Jan 6.

Department of General Surgery, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.

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http://dx.doi.org/10.1007/s12029-018-00198-2DOI Listing
January 2019
2 Reads

Esophageal Squamous Cell Carcinoma Metastatic to Umbilicus: a Case Report with Review of Literature.

J Gastrointest Cancer 2018 Dec 14. Epub 2018 Dec 14.

Laboratory Oncology Unit, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, 110029, India.

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http://link.springer.com/10.1007/s12029-018-00185-7
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http://dx.doi.org/10.1007/s12029-018-00185-7DOI Listing
December 2018
3 Reads

Surgery for Locally Advanced GIT Cancers Has Potentially Good Postoperative Outcomes in a Tertiary Hospital.

J Gastrointest Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Background: Adhesions and infiltration into adjacent tissues are present in about 12% of gastrointestinal (GIT) cancers. These adhesions have high potential risk of malignancy. Free resection margin is a predictor of good survival in such patients. Read More

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http://dx.doi.org/10.1007/s12029-018-0181-5DOI Listing
December 2018
2 Reads

MAEL Cancer-Testis Antigen as a Diagnostic Marker in Primary Stages of Gastric Cancer with Helicobacter pylori Infection.

J Gastrointest Cancer 2018 Nov 28. Epub 2018 Nov 28.

Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: Gastric cancer (GC) is the third leading cause of cancer related deaths in the world. Cancer testis antigens (CTAs) are involved in tumor progression of various cancers. These markers have not any expression or minimally expression in normal tissues, highlighting them as efficient methods for molecular targeted therapy. Read More

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http://dx.doi.org/10.1007/s12029-018-0183-3DOI Listing
November 2018
3 Reads

Clinicopathological Criteria Defining Mucinous Appendiceal Tumors from 2476 Appendectomies: a Single-Center Retrospective Study.

J Gastrointest Cancer 2018 Nov 28. Epub 2018 Nov 28.

Pathology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.

Objectives: Mucinous appendiceal tumors (MATs) constitute 0.2-0.3% of appendectomies. Read More

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http://link.springer.com/10.1007/s12029-018-0182-4
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http://dx.doi.org/10.1007/s12029-018-0182-4DOI Listing
November 2018
26 Reads

Anorectal Cancer in Crohn's Disease Has a Poor Prognosis Due to its Advanced Stage and Aggressive Histological Features: a Systematic Literature Review of Japanese Patients.

J Gastrointest Cancer 2018 Nov 26. Epub 2018 Nov 26.

Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.

Background: Patients with Crohn's disease (CD) are generally known to be at an increased risk of cancer. The anorectal area is the most frequent cancer site in Japanese CD patients. However, the risks are not well defined. Read More

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http://dx.doi.org/10.1007/s12029-018-0180-6DOI Listing
November 2018
15 Reads

Pancreatic Cancer and Immunotherapy: Resistance Mechanisms and Proposed Solutions.

J Gastrointest Cancer 2019 Mar;50(1):1-8

Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.

Background: Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the most aggressive and lethal diseases in the world. The success of immunotherapy in other types of malignancy has led to further trials to understand better the role of immunotherapy in PDAC. However, initial studies with immunotherapy, namely, the checkpoint inhibitors, in PDAC have not been met with the same outcomes. Read More

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http://link.springer.com/10.1007/s12029-018-0179-z
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http://dx.doi.org/10.1007/s12029-018-0179-zDOI Listing
March 2019
18 Reads

Follicular Dendritic Cell Sarcoma of Gastrointestinal Tract: an Uncommon Lesion, Commonly Missed.

J Gastrointest Cancer 2018 Nov 15. Epub 2018 Nov 15.

Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Introduction: Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm, accounting for only 0.4% of soft-tissue sarcomas. It shows both nodal and extranodal involvement. Read More

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http://link.springer.com/10.1007/s12029-018-0178-0
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http://dx.doi.org/10.1007/s12029-018-0178-0DOI Listing
November 2018
9 Reads

Outcomes of Neoadjuvant Chemoradiation in Patients with Gastro-esophageal Junction Adenocarcinoma: a Retrospective Cohort Study in Iran.

J Gastrointest Cancer 2018 Nov 7. Epub 2018 Nov 7.

Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: The optimal treatment for locally advanced GEJ and cardia adenocarcinoma is controversial. Several studies have shown that treating these patients with neoadjuvant chemoradiotherapy followed by surgery leads to survival benefits, and there are also studies that have declared conflicting results. It seems that there is still room for discussion. Read More

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http://link.springer.com/10.1007/s12029-018-0155-7
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http://dx.doi.org/10.1007/s12029-018-0155-7DOI Listing
November 2018
17 Reads

Synchronous Adeno-squamous Carcinoma of Gallbladder and Adenocarcinoma of Common Bile Duct: Twin Trouble.

J Gastrointest Cancer 2018 Nov 6. Epub 2018 Nov 6.

Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

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http://dx.doi.org/10.1007/s12029-018-0177-1DOI Listing
November 2018
3 Reads

Radio-pathological Correlation of 18F-FDG PET in Characterizing Gallbladder Wall Thickening.

J Gastrointest Cancer 2018 Nov 6. Epub 2018 Nov 6.

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Aim: Thick-walled gallbladder is difficult to characterize on conventional imaging. 18F-FDG PET was used to differentiate benign and malignant wall thickness and compared with histopathology.

Methods: Thirty patients with gallbladder (GB) wall thickening (focal > 4 mm and diffuse > 7 mm), underwents uspected on  ultrasound, or CT scan, and underwent 18F-FDG PET. Read More

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http://link.springer.com/10.1007/s12029-018-0176-2
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http://dx.doi.org/10.1007/s12029-018-0176-2DOI Listing
November 2018
11 Reads

Recurrent Pancreatitis Secondary to Diffuse Large B Cell Lymphoma.

J Gastrointest Cancer 2018 Nov 5. Epub 2018 Nov 5.

Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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http://dx.doi.org/10.1007/s12029-018-0175-3DOI Listing
November 2018
2 Reads

Testicular Choriocarcinoma Metastasizing to the Small Bowel Causing Intussusception: Case Report.

J Gastrointest Cancer 2018 Oct 27. Epub 2018 Oct 27.

Pathology Department, Texas Tech Health and Science Center, El Paso, TX, USA.

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http://dx.doi.org/10.1007/s12029-018-0172-6DOI Listing
October 2018
3 Reads

Platelet and Neutrophil Counts as Predictive Markers of Neoadjuvant Therapy Efficacy in Rectal Cancer.

J Gastrointest Cancer 2018 Oct 24. Epub 2018 Oct 24.

Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada.

Aims: To investigate pretreatment platelet and neutrophil counts as well as a combined platelet-neutrophil (PN) index for prognostic information in patients with rectal adenocarcinoma that received neoadjuvant treatment.

Patients And Methods: Charts from 164 patients with localized rectal adenocarcinoma were retrospectively reviewed, and 112 patients with complete data were included in the study. Patients were stratified in groups according to their neutrophil counts, platelet counts, and a combined platelet/neutrophil (PN) index. Read More

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http://link.springer.com/10.1007/s12029-018-0173-5
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http://dx.doi.org/10.1007/s12029-018-0173-5DOI Listing
October 2018
9 Reads

Improved Survival of Hepatocellular Carcinoma Patients Diagnosed with a Dedicated Screening Programme-a Propensity Score Adjusted Analysis.

J Gastrointest Cancer 2018 Oct 22. Epub 2018 Oct 22.

Hepatology and Liver Transplant Medicine Unit, Flinders Medical Centre, Bedford Park, SA, Australia.

Aim: To assess the overall survival (OS) in those with hepatocellular carcinoma (HCC) diagnosed within a programmatic, centrally co-ordinated, regional screening programme.

Methods: A retrospective cohort analysis of consecutive HCC patients diagnosed between 2004 and 2013. Patients were followed up till death or end of study period (30 April 2015). Read More

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http://dx.doi.org/10.1007/s12029-018-0171-7DOI Listing
October 2018
3 Reads

Stereotactic Body Radiation Therapy (SBRT) Using CyberKnife in Oligometastatic Cancer Patients; Retrospective Evaluation, Single Institution Experience.

J Gastrointest Cancer 2018 Oct 6. Epub 2018 Oct 6.

Radiation oncology department King Faisal specialized hospital and research center, Riyadh, Saudi Arabia.

Objectives: We retrospectively evaluate local control rate at 6 months and 1 year in oligometastatic cancer patients treated with SBRT using CyberKnife.

Methods: Total of 21 patients with 24 treatment sites from February 2014 till June 2017 who were treated with SBRT in our institution were included in this study.

Results: Eleven patients were males, 10 patients were females, median age at diagnosis was 63 years, and colorectal cancer is the most commonly diagnosed cancer in 18 patients. Read More

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http://link.springer.com/10.1007/s12029-018-0170-8
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http://dx.doi.org/10.1007/s12029-018-0170-8DOI Listing
October 2018
19 Reads

Faecal Occult Blood Point-of-Care Tests.

J Gastrointest Cancer 2018 Dec;49(4):402-405

Department of Clinical Biochemistry, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka St 265, 30-663, Cracow, Poland.

Background: Early detection of colorectal cancer decreases the risk of mortality. Faecal occult blood tests (FOBT) are recognised as a useful tool for colorectal cancer screening. These non-invasive, rapid, and easy-to-carry assays are very often used as a point-of-care test and for self-testing. Read More

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http://link.springer.com/10.1007/s12029-018-0169-1
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http://dx.doi.org/10.1007/s12029-018-0169-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208834PMC
December 2018
7 Reads

Clostridium septicum Myonecrosis Secondary to an Occult Small Bowel Adenocarcinoma.

J Gastrointest Cancer 2018 Sep 10. Epub 2018 Sep 10.

Spectrum Health Hospital, Acute Care Surgery, 221 Michigan NE, Suite 402, Grand Rapids, MI, 49503, USA.

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http://dx.doi.org/10.1007/s12029-018-0168-2DOI Listing
September 2018
2 Reads

Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.

J Gastrointest Cancer 2018 Sep 5. Epub 2018 Sep 5.

Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, 500 W. Thomas Road, Suite 500, Phoenix, AZ, USA.

Purpose: The vitamin D receptor (VDR) endocrine system has emerged as an endogenous pleiotropic biological cell regulator with anti-neoplastic effects on breast, colorectal, and prostatic adenocarcinomas. We studied the association of gene expression, polymorphisms of VDR, CYP27B1, and CYP24A1 genes and serum vitamin D levels as surrogate markers of disease progression in patients with acid reflux, Barrett's esophagus (BE), or esophageal adenocarcinoma (EAC).

Methods: We analyzed blood and tissue samples from patients with biopsy-confirmed BE or EAC for vitamin D levels, gene expressions, and polymorphisms in VDR (FokI [F/f], BsmI [B/b], ApaI [A/a], and TaqI [T/t]), CYP27B1 (HinfI [H/h]), and CYP24A1 (Hpy1881 [Y/y]). Read More

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http://dx.doi.org/10.1007/s12029-018-0164-6DOI Listing
September 2018
9 Reads