9,017 results match your criteria Journal of Gastroenterology and Hepatology[Journal]


N-myc and STAT interactor correlates with severity and prognosis in acute-on-chronic liver failure of hepatitis B virus.

J Gastroenterol Hepatol 2019 Feb 16. Epub 2019 Feb 16.

Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China.

Background And Aim: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is characterized by acute deterioration of chronic liver disease with excessive inflammation. N-myc and STAT interactor (NMI), an inflammation-mediated protein, involves in various inflammatory related diseases, but the role of NMI in development and prognosis in HBV-ACLF remains to be elucidated.

Methods: Serum NMI from healthy controls (HCs, n=20), chronic hepatitis B (CHB, n=50) patients and HBV-ACLF patients (n=50) were determined using ELISA. Read More

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http://dx.doi.org/10.1111/jgh.14634DOI Listing
February 2019

Association of Low Alanine Aminotransferase with Loss of Independence or Death: a 5-year Population-based Cohort Study.

J Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background & Aim: Alanine aminotransferase (ALT) is an important enzyme for amino acid metabolism and gluconeogenesis, and low ALT is an indicator of vitamin B6 deficiency. However, it is unknown whether individuals with low ALT are likely to develop loss of independence (LOI) or death. We investigated the association of low ALT with LOI or death in the elderly. Read More

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http://dx.doi.org/10.1111/jgh.14631DOI Listing
February 2019

Multiple recurrences after endoscopic removal of common bile duct stones: A retrospective analysis of 976 cases.

J Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Gastroenterology, Graduate school of Medicine, The University of Tokyo, Tokyo, Japan.

Background And Aims: Recurrences after endoscopic treatment of common bile duct stones (CBDS) are common. The aims of this study were to identify risk factors for recurrences of CBDS and to evaluate the effect of interventions for prevention of further recurrences.

Methods: A total of 976 patients who underwent endoscopic treatment of CBDS were retrospectively studied. Read More

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http://dx.doi.org/10.1111/jgh.14630DOI Listing
February 2019

Non-invasive structure-function assessment of the liver by 2D time-harmonic elastography and the dynamic Liver MAximum capacity (LiMAx) test.

J Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background And Aim: Accurate assessment of structural and functional characteristics of the liver could improve the diagnosis and the clinical management of patients with chronic liver diseases. However, the structure-function relationship in the progression of chronic liver disease remains elusive. The aim of this study is the combined measurement of liver function by the C-methacetin Liver MAximum capacity (LiMAx) test and tissue-structure related stiffness by 2D time-harmonic elastography (THE) for the assessment of liver disease progression. Read More

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http://dx.doi.org/10.1111/jgh.14629DOI Listing
February 2019

Intraluminal therapy for Helicobacter pylori infection.

J Gastroenterol Hepatol 2019 Feb 8. Epub 2019 Feb 8.

Division of Gastroenterology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.

Background And Aim: Several strategies have been proposed to increase the eradication rate of Helicobacter pylori. However, the widespread increasing resistance rates to current multiple-dose oral antibiotics therapies call for alternative therapeutic approaches. We aim to develop a novel intraluminal therapy for Helicobacter pylori infection (ILTHPI). Read More

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http://dx.doi.org/10.1111/jgh.14627DOI Listing
February 2019

A multicenter cohort analysis of significant complications following elective outpatient therapeutic procedures in the pediatric age range.

J Gastroenterol Hepatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Gastroenterology, Sheffield Children's Hospital, Western Bank, Sheffield, S10 2TH, United Kingdom.

Background: Current understanding of specific, therapeutic procedure associated complications in pediatric patients remains limited.

Aims: To determine the frequency of significant complications in pediatric age-range subjects following the principal therapeutic endoscopic procedures.

Methods: Retrospective multi-institutional, ICD9 CM, CTC and CPT based database (PHIS) analysis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.14626
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http://dx.doi.org/10.1111/jgh.14626DOI Listing
February 2019
3 Reads

Risk factors of rescue bismuth quadruple therapy failure for Helicobacter pylori eradication.

J Gastroenterol Hepatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Internal medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea.

Background And Aim: Failure of bismuth quadruple therapy for Helicobacter pylori eradication is frequently observed. To increase the eradication rate, comprehensive analyses need to be performed regarding risk factors of bismuth quadruple therapy failure based on complete standard culture and antimicrobial susceptibility testing results.

Methods: Patients with history of failed 1st therapy who had H. Read More

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http://dx.doi.org/10.1111/jgh.14625DOI Listing
February 2019

Outcomes of ulcerative colitis-associated dysplasia patients referred for potential endoscopic submucosal dissection.

J Gastroenterol Hepatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Gastroenterology, University of Ulsan College of Medicine, Seoul, Korea.

Background: The feasibility of endoscopic submucosal dissection (ESD) as a treatment option for dysplasia in ulcerative colitis (UC) has been reported but the associated therapeutic decision-making and clinical outcomes have not been extensively investigated.

Methods: We retrospectively reviewed 25 UC patients who were referred for potential ESD of non-polypoid or sessile dysplasia. We analyzed the treatment decisions and the ESD and colectomy outcomes for this patient group. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.14623
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http://dx.doi.org/10.1111/jgh.14623DOI Listing
February 2019
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Long-term outcomes of patients with Crohn's disease who received infliximab or adalimumab as the first-line biologics.

J Gastroenterol Hepatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background And Aim: Although previous studies compared the efficacy of infliximab (IFX) versus adalimumab (ADA) as the first-line biologics for Crohn's disease (CD), the difference in long-term prognosis based on which biologic was used first has scarcely been reported. In particular, the clinical courses after loss of response (LOR) of the first-line biologics are largely unknown.

Methods: A multicenter, retrospective study was performed. Read More

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http://dx.doi.org/10.1111/jgh.14624DOI Listing
February 2019

Gastrointestinal: Endoscopic diverticulectomy for the treatment of Zenker's diverticulum with a unique "tip": A first case report in Japan.

J Gastroenterol Hepatol 2019 Feb 4. Epub 2019 Feb 4.

Division of Gastroenterology, Niigata University Medical and Dental Hospital, Japan.

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http://dx.doi.org/10.1111/jgh.14599DOI Listing
February 2019

Change in treatment paradigm in people who previously injected drugs with chronic hepatitis C in the era of direct-acting antiviral therapy.

J Gastroenterol Hepatol 2019 Feb 1. Epub 2019 Feb 1.

Institute of Digestive Disease, Hong Kong.

Background: Chronic hepatitis C virus (HCV) infection is highly prevalent among people who inject drugs but is often undiagnosed. The treatment paradigm for HCV patients has been changing since the availability of direct-acting antiviral (DAA) treatment. We aimed to evaluate the change in treatment paradigm of people who previously injected drugs (ex-PWID) in Hong Kong before and after the availability of DAA. Read More

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http://dx.doi.org/10.1111/jgh.14622DOI Listing
February 2019

The emerging role of big data in gastroenterology and hepatology.

J Gastroenterol Hepatol 2019 Feb;34(2):307-308

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://doi.wiley.com/10.1111/jgh.14606
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http://dx.doi.org/10.1111/jgh.14606DOI Listing
February 2019
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Superior clinical outcomes of peroral endoscopic myotomy compared with balloon dilation in all achalasia subtypes.

J Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Gastroenterology, Asan Digestive Disease Research Institute, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background And Aim: Optimal treatment modalities for each of the three subtypes of achalasia are still under debate. Differences in prognosis and long-term outcomes between peroral endoscopic myotomy (POEM) and balloon dilation (BD) are also unclear. We aimed to compare the treatment outcomes of BD and POEM in each subtype of achalasia by using information from the manometry database of a tertiary referral center in Korea. Read More

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http://doi.wiley.com/10.1111/jgh.14616
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http://dx.doi.org/10.1111/jgh.14616DOI Listing
January 2019
4 Reads

The balance of type 1 and type 2 immune responses in the contexts of hepatitis B infection and hepatitis D infection.

J Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD.

Background: Hepatitis delta virus (HDV) infection is the most rapidly progressive chronic viral hepatitis. Little is understood about the immune responses to HDV.

Aim: To characterize the systemic immune environments of hepatitis B virus (HBV) and HDV patients at various disease stages. Read More

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http://dx.doi.org/10.1111/jgh.14617DOI Listing
January 2019
1 Read

Sofosbuvir-based direct acting antiviral therapies for patients with hepatitis C virus genotype 2 infection.

J Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Background And Aim: Data regarding the comparative effectiveness and safety of sofosbuvir (SOF) in combination with ribavirin (RBV), daclatasvir (DCV), or ledipasvir (LDV) for hepatitis C virus genotype 2 (HCV-2) patients were limited. We aimed to evaluate the performance of these regimens in Taiwan.

Methods: One hundred eighty-seven HCV-2 patients with compensated liver diseases receiving SOF in combination with RBV (n = 82), DCV (n = 66), or LDV (n = 39) for 12 weeks were retrospectively enrolled. Read More

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http://dx.doi.org/10.1111/jgh.14615DOI Listing
January 2019

Gastrointestinal: Positron emission tomography-computed tomography imaging of multifocal intestinal metastasis from primary lung cancer.

Authors:
B D Nguyen M S Ryan

J Gastroenterol Hepatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Laboratory Medicine, Mayo Clinic, Scottsdale, Arizona, USA.

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http://dx.doi.org/10.1111/jgh.14591DOI Listing
January 2019

Gastrointestinal: Esophageal stricture with esophageal intramural pseudodiverticulosis.

J Gastroenterol Hepatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Gastroenterology and Hepatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.

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http://dx.doi.org/10.1111/jgh.14597DOI Listing
January 2019

Gastrointestinal: Radiation proctitis: Or is it something else?

J Gastroenterol Hepatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Gastroenterology, GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.

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http://dx.doi.org/10.1111/jgh.14592DOI Listing
January 2019
1 Read

Gastrointestinal: Successful diagnosis of primary peritoneal serous carcinoma by endoscopic ultrasound-guided through-the-needle forceps biopsy.

J Gastroenterol Hepatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/jgh.14593DOI Listing
January 2019

Gastrointestinal: A case of small bowel obstruction caused by a bezoar, preoperatively found by double-balloon enteroscopy.

J Gastroenterol Hepatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Mie University, Tsu, Japan.

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http://dx.doi.org/10.1111/jgh.14589DOI Listing
January 2019

Teprenone improves gastric mucosal injury and dyspeptic symptoms in long-term nonsteroidal anti-inflammatory drug users.

J Gastroenterol Hepatol 2019 Jan 25. Epub 2019 Jan 25.

Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background And Aim: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a major cause of gastric mucosal lesions. In China, teprenone is frequently prescribed as a mucoprotective agent, but the literature regarding their efficacy is limited. Our purpose was to address the effects of teprenone on long-term NSAID-associated gastric mucosal lesions. Read More

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http://doi.wiley.com/10.1111/jgh.14614
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http://dx.doi.org/10.1111/jgh.14614DOI Listing
January 2019
2 Reads

Comparison of polyp detection during both insertion and withdrawal versus only withdrawal of colonoscopy: A prospective randomized trial.

J Gastroenterol Hepatol 2019 Jan 24. Epub 2019 Jan 24.

Division of Gastroenterology, Department of Medicine, Evergreen General Hospital, Taoyuan, Taiwan.

Background And Aims: Polyps seen and not removed during colonoscope insertion are sometimes unable to be found during withdrawal. We aimed to evaluate whether additional inspection and polypectomy during insertion increases adenoma detection rate (ADR) compared to inspection and polypectomy entirely during withdrawal.

Methods: A total of 421 patients aged ≥45 years and undergoing colonoscopy were prospectively randomized to receive inspection and polypectomy during both insertion and withdrawal (study group), or inspection and polypectomy entirely during withdrawal (control group). Read More

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http://dx.doi.org/10.1111/jgh.14613DOI Listing
January 2019
1 Read

Long-term outcome and recurrence factors after percutaneous cholecystostomy as a definitive treatment for acute cholecystitis.

J Gastroenterol Hepatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background And Aim: Percutaneous cholecystostomy (PC) has been frequently used as an alternative treatment for acute cholecystitis in seriously ill patients unfit for surgery. The aim of this study was to investigate the recurrence rate and risk factors of recurrence.

Methods: Medical records of 102 patients who were followed up for more than 1 year after PC tube removal among 716 patients who underwent PC for acute cholecystitis treatment were retrospectively analyzed. Read More

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http://dx.doi.org/10.1111/jgh.14611DOI Listing
January 2019
3 Reads

Regional variations in the use of biologics and immunomodulators among Korean patients with inflammatory bowel diseases.

J Gastroenterol Hepatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Biostatistics, Graduate School of Public Health, Yonsei University, Seoul, Korea.

Background And Aim: Variation in medical care can be an obstacle to improving quality and outcome of treatment. We conducted a nationwide, population-based study to identify regional variations in medication prescription rates in Korean patients with inflammatory bowel diseases (IBDs).

Methods: Using the National Health Insurance claims, we collected data on patients diagnosed with IBD (8974 cases of Crohn's disease [CD] and 17 167 cases of ulcerative colitis [UC]) between 2010 and 2016. Read More

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http://dx.doi.org/10.1111/jgh.14609DOI Listing
January 2019
2 Reads

Expert consensus on the clinical management of pyrrolizidine alkaloid induced hepatic sinusoidal obstruction syndrome.

J Gastroenterol Hepatol 2019 Jan 22. Epub 2019 Jan 22.

Department of Gastroenterology, Zhongshan Hospital of Fudan University.

Hepatic sinusoidal obstruction syndrome (HSOS) is a hepatic vascular disease presenting with abdominal distension, pain in the hepatic region, ascites, jaundice, and hepatomegaly. In China, this disease is often associated with the oral intake of plants that contain pyrrolidine alkaloids (PAs). The existing guidelines are limited to HSOS associated with haematopoietic stem cell transplantation in Western countries. Read More

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http://doi.wiley.com/10.1111/jgh.14612
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http://dx.doi.org/10.1111/jgh.14612DOI Listing
January 2019
7 Reads

Gastrointestinal: Reappraisal of the usefulness of percutaneous transhepatic cholangioscopy for indeterminate distal biliary strictures.

J Gastroenterol Hepatol 2019 Jan 22. Epub 2019 Jan 22.

Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/jgh.14588DOI Listing
January 2019
1 Read

Clinical features of hepatocellular carcinoma in nonalcoholic fatty liver disease patients without advanced fibrosis.

J Gastroenterol Hepatol 2019 Jan 22. Epub 2019 Jan 22.

Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.

Background And Aim: The prevalence of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD-HCC) is increasing. Unfortunately, NAFLD frequently develops into HCC without liver cirrhosis. Therefore, we investigated the clinical features of hepatocellular carcinoma in nonalcoholic fatty liver disease patients without advanced fibrosis. Read More

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http://dx.doi.org/10.1111/jgh.14608DOI Listing
January 2019
3 Reads

Correlation of Barrett's Esophagus with Colorectal Polyps in Japanese Patients: A Retrospective Chart Review.

J Gastroenterol Hepatol 2019 Jan 22. Epub 2019 Jan 22.

Department of Internal Medicine, Saga Medical School, Saga, Japan.

Background And Aim: Barrett's esophagus and colorectal polyps have several overlapping risk factors. Whereas several reports in Western countries have indicated a close relationship between Barrett's esophagus and colorectal polyps, the relationship between these two diseases remains unclear in Japan. This study was performed to determine whether the prevalence of Barrett's esophagus is related to that of colorectal polyps in Japanese patients. Read More

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http://dx.doi.org/10.1111/jgh.14610DOI Listing
January 2019
3 Reads

Association of low skeletal muscle mass with advanced liver fibrosis in patients with non-alcoholic fatty liver disease.

J Gastroenterol Hepatol 2019 Jan 22. Epub 2019 Jan 22.

Division of Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.

Background And Aim: Although low skeletal muscle mass (LSMM) is known to increase the risk of non-alcoholic fatty liver disease (NAFLD), limited reports have described the relationship between LSMM and advanced fibrosis. Here, we investigated the association between LSMM and advanced liver fibrosis in NAFLD patients.

Methods: Fatty liver was diagnosed using ultrasound, and appendicular skeletal muscle mass (ASM) was measured using bioelectrical impedance analysis. Read More

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http://doi.wiley.com/10.1111/jgh.14607
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http://dx.doi.org/10.1111/jgh.14607DOI Listing
January 2019
8 Reads

Gastrointestinal: Glomus tumor: A rare submucosal tumor of the stomach.

J Gastroenterol Hepatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Gastroenterology and Hepatology, Japanese Red Cross Osaka Hospital, Osaka, Japan.

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http://dx.doi.org/10.1111/jgh.14594DOI Listing
January 2019

Hepatobiliary and Pancreatic: Bleeding in amyloid liver: A rare presentation of primary liver amyloidosis.

J Gastroenterol Hepatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Medicine, Section of Gastroenterology, Aga Khan University Hospital, Karachi, Pakistan.

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http://dx.doi.org/10.1111/jgh.14567DOI Listing
January 2019
2 Reads

Hepatobiliary and Pancreatic: A procalcitonin-secreting and calcitonin-secreting pancreatic neuroendocrine carcinoma.

J Gastroenterol Hepatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Pathology and Microbiology, Graduate School of Biomedical Sciences, Saga University, Saga, Japan.

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http://dx.doi.org/10.1111/jgh.14568DOI Listing
January 2019
1 Read

Long-term outcomes after therapeutic ERCP using balloon-assisted enteroscopy for anastomotic stenosis of choledocho-/pancreaticojejunostomy.

J Gastroenterol Hepatol 2019 Jan 16. Epub 2019 Jan 16.

Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.

Background And Aim: Data on long-term outcomes after therapeutic endoscopic retrograde cholangiopancreatography (ERCP) using balloon-assisted enteroscopy (BAE) for choledochojejunal anastomotic stenosis (CJS) or pancreaticojejunal anastomotic stenosis (PJS) remain limited. We retrospectively assessed the long-term results of patients who achieved clinical success using BAE for CJS and PJS.

Methods: Patients who achieved technical and clinical success for CJS or PJS by BAE-ERCP and were followed up for more than 6 months after the initial BAE-ERCP therapy were retrospectively identified at 11 Japanese institutions. Read More

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http://doi.wiley.com/10.1111/jgh.14605
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http://dx.doi.org/10.1111/jgh.14605DOI Listing
January 2019
4 Reads

Usefulness of newly modified fully covered metallic stent of 12 mm in diameter and anti-migration feature for periampullary malignant biliary strictures: Comparison with conventional standard metal stent.

J Gastroenterol Hepatol 2019 Jan 16. Epub 2019 Jan 16.

Digestive Disease Center and Research Institute, Department of Internal Medicine, SoonChunHyang University School of Medicine, Bucheon, Korea.

Backgrounds: Fully covered self-expandable metal stent (FCSEMS) are preferred for distal malignant biliary stricture (MBS). However, stent migration is a major adverse event of FCSEMS, especially for far distal MBS. We evaluated the usefulness of newly modified FCSEMS (M-FCSEMS) having 12 mm in diameter and anti-migration feature to minimize stent migration compared with the conventional FCSEMS (C-FCSEMS). Read More

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http://dx.doi.org/10.1111/jgh.14602DOI Listing
January 2019
2 Reads

Post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with asymptomatic common bile duct stones.

J Gastroenterol Hepatol 2019 Jan 16. Epub 2019 Jan 16.

Department of Gastroenterology, Kumamoto Chuo Hospital, 1-5-1, Tainoshima, Minami-ku, Kumamoto City, Kumamoto, 862-0965, Japan.

Background And Aim: For asymptomatic common bile duct (CBD) stones, removal by endoscopic retrograde cholangiopancreatography (ERCP) is recommended in available guidelines. However, few studies have reported the risk of post-ERCP pancreatitis (PEP), which is the most common and serious ERCP-related complication for asymptomatic CBD stones. We performed a propensity-score-matching analysis to examine the risk of PEP in therapeutic ERCP for asymptomatic CBD stones. Read More

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http://dx.doi.org/10.1111/jgh.14604DOI Listing
January 2019
3 Reads

Renaissance in gastroenterology and hepatology.

Authors:
Joseph Sung

J Gastroenterol Hepatol 2019 Jan;34(1):5-6

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http://dx.doi.org/10.1111/jgh.14582DOI Listing
January 2019
2 Reads

Gastrointestinal: Endoscopic injection sclerotherapy for duodenal vascular malformation in blue rubber bleb nevus syndrome.

J Gastroenterol Hepatol 2019 Jan 14. Epub 2019 Jan 14.

Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.

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http://dx.doi.org/10.1111/jgh.14590DOI Listing
January 2019

Colonic diverticular bleeding and predictors of the length of hospitalization: An observational study.

J Gastroenterol Hepatol 2019 Jan 12. Epub 2019 Jan 12.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Background And Aim: A significant percentage of patients with colonic diverticular bleeding (CDB) experience bleeding that is severe enough to necessitate prolonged hospitalization. Prolonged hospitalization causes deterioration in patients' quality of life, as well as difficulties with cost-effective utilization of medical resources, and is a financial burden to the society. Therefore, we investigated the factors associated with the length of hospitalization for the optimal management of patients hospitalized with CDB. Read More

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http://dx.doi.org/10.1111/jgh.14603DOI Listing
January 2019
1 Read

Modified non-flared fully covered self-expandable metal stent versus plastic stent for preoperative biliary drainage in patients with resectable malignant biliary obstruction.

J Gastroenterol Hepatol 2019 Jan 7. Epub 2019 Jan 7.

Digestive Disease Center and Research Institute, Department of Internal Medicine, Soon Chun Hyang University School of Medicine, Bucheon, Cheonan and Seoul, Korea.

Background: Fully covered self-expandable metal stents (FCSEMS) may be better than plastic stents (PS) for preoperative biliary drainage (PBD) to relieve cholangitis or jaundice for resectable malignant biliary obstruction (MBO). However, modification of current FCSEMS designed originally for nonresectable MBO is needed to be a proper stent for PBD. The aim of this study was to evaluate the possible superiority of non-flared modified FCSEMS (M-FCSEMS) with 12 mm diameter and waist of central portion over PS in patients with resectable MBO. Read More

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http://doi.wiley.com/10.1111/jgh.14600
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http://dx.doi.org/10.1111/jgh.14600DOI Listing
January 2019
6 Reads

Warfarin use increases bleeding risk in hemodialysis patients with atrial fibrillation: A meta-analysis of cohort studies.

J Gastroenterol Hepatol 2019 Jan 6. Epub 2019 Jan 6.

Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

Background And Aim: Atrial fibrillation is one of the most common comorbid conditions in hemodialysis patients, and warfarin is widely prescribed anticoagulant to prevent thromboembolic complications in such patients. In the last decade, several epidemiological studies pointed out the risk of bleeding with the use of warfarin. So, this meta-analysis is aimed to assess the bleeding risk associated with the use of warfarin. Read More

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http://dx.doi.org/10.1111/jgh.14601DOI Listing
January 2019
2 Reads

Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study.

J Gastroenterol Hepatol 2019 Jan 1. Epub 2019 Jan 1.

Department of Diabetes and Endocrinology, University of KwaZulu-Natal, Durban, South Africa.

Background And Aim: The aim of this study was to assess the prevalence and characteristics of celiac disease (CD) in all patients with type 1 diabetes mellitus attending a tertiary adult diabetes clinic in Durban, South Africa.

Methods: This was a cross-sectional observational study that screened 202 patients; of these, 56.4% were African (Black), 31. Read More

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http://doi.wiley.com/10.1111/jgh.14596
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http://dx.doi.org/10.1111/jgh.14596DOI Listing
January 2019
13 Reads

HOMA-IR: An independent predictor of advanced liver fibrosis in nondiabetic non-alcoholic fatty liver disease.

J Gastroenterol Hepatol 2019 Jan 1. Epub 2019 Jan 1.

Department of Hepatology, Osaka City University, Osaka, Japan.

Background And Aim: Although non-alcoholic fatty liver disease (NAFLD) is common in the general population, identifying patients with advanced fibrosis remains a challenge. We investigated whether the homeostasis model assessment parameter of insulin resistance (HOMA-IR), an index of IR and one of the most important metabolic factors, is an independent predictive factor for advanced fibrosis in nondiabetic patients with NAFLD.

Methods: This was a retrospective, cross-sectional multicenter study. Read More

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http://doi.wiley.com/10.1111/jgh.14595
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http://dx.doi.org/10.1111/jgh.14595DOI Listing
January 2019
9 Reads

Peripherally acting μ-opioid antagonist for the treatment of opioid-induced constipation: Systematic review and meta-analysis.

J Gastroenterol Hepatol 2018 Dec 29. Epub 2018 Dec 29.

The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Background And Aim: Opioid-induced constipation (OIC) is a frequent adverse event (AE) that impairs patients' quality of life (QOL). Peripherally acting μ-opioid receptor antagonists (PAMORAs) have been recognized as a treatment option for OIC, but the effect consistent across the studies has not been evaluated.

Methods: We conducted a quantitative meta-analysis to explore the efficacy of PAMORA for OIC (registered with PROSPERO: CRD42018085298). Read More

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http://dx.doi.org/10.1111/jgh.14586DOI Listing
December 2018
2 Reads

Abnormalities in acute salivary biochemical characteristic responses to gustatory stimulation with citric acid in chronic non-atrophic gastritis.

J Gastroenterol Hepatol 2018 Dec 29. Epub 2018 Dec 29.

Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou, China.

Background And Aim: Salivary characteristics are altered in gastrointestinal diseases and related to oral taste disorder. However, specific salivary biochemical characteristics and their relationships with oral taste disturbances in chronic non-atrophy gastritis (CNAG) remain uncertain.

Methods: Seventy patients with CNAG and 70 subjects in healthy control group (HCG) were enrolled in our study. Read More

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http://dx.doi.org/10.1111/jgh.14587DOI Listing
December 2018
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Gastrointestinal: Colon cast with segmental stricture following colonic ischemia.

J Gastroenterol Hepatol 2018 Dec 27. Epub 2018 Dec 27.

Center for Crohn's and Colitis, Department of Gastroenterology, Kyung Hee University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/jgh.14550DOI Listing
December 2018
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Characteristics of non-alcoholic steatohepatitis among lean patients in Japan: Not uncommon and not always benign.

J Gastroenterol Hepatol 2018 Dec 27. Epub 2018 Dec 27.

Department of Internal Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.

Background And Aim: To elucidate features of nonobese non-alcoholic fatty liver disease (NAFLD), we assessed Japanese patients with NAFLD stratified by body mass index (BMI) and by sex.

Methods: Biopsy-proven 762 NAFLD patients (404 men) were classified into three groups by the Japanese criteria: nonobese group (BMI < 25 kg/m ), obese group (25 to 30), and severely obese group (≥ 30). Clinicopathological features and single nucleotide polymorphism of patatin-like phospholipase 3 (PNPLA3) rs738409 were investigated, and body composition analysis was performed by bioelectrical impedance analysis and computed tomography. Read More

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http://dx.doi.org/10.1111/jgh.14585DOI Listing
December 2018
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Compound polysaccharides ameliorate experimental colitis by modulating gut microbiota composition and function.

J Gastroenterol Hepatol 2018 Dec 27. Epub 2018 Dec 27.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, China.

Background And Aim: Inflammatory bowel disease results from a dysregulated immune response to intestinal microbial flora in individuals with genetic predisposition(s). This study aimed to determine the effects of compound polysaccharides (CP) containing yam polysaccharide and inulin on the rat model of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) and to explain the mechanism in terms of gut microbiota composition and function.

Methods: Male SD rats were divided into three groups: the control group, the model group, and the CP group. Read More

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http://doi.wiley.com/10.1111/jgh.14583
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http://dx.doi.org/10.1111/jgh.14583DOI Listing
December 2018
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Immunogenicity is not the driving force of treatment failure in vedolizumab-treated inflammatory bowel disease patients.

J Gastroenterol Hepatol 2018 Dec 27. Epub 2018 Dec 27.

Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

Background And Aim: The pivotal GEMINI trials reported low immunogenicity of vedolizumab. However, anti-vedolizumab antibodies (AVA) are frequently underestimated because most assays are not drug-tolerant and unable to detect antidrug antibodies while there is drug in the circulation. This study aimed to explore which antidrug antibody assay is best suited to detect AVA and investigated immunogenicity of vedolizumab in inflammatory bowel disease (IBD) patients discontinuing vedolizumab therapy. Read More

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http://dx.doi.org/10.1111/jgh.14584DOI Listing
December 2018
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Antitumor activity in colorectal cancer induced by hinokiflavone.

J Gastroenterol Hepatol 2018 Dec 21. Epub 2018 Dec 21.

Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Background And Aim: Colorectal cancer is one of the most common malignant disease worldwide with highly metastatic potential. Identification of effective therapeutic treatment overcoming such disease is an urgent need. Our study focuses on hinokiflavone as an antitumor agent against colorectal cancer. Read More

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http://doi.wiley.com/10.1111/jgh.14581
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http://dx.doi.org/10.1111/jgh.14581DOI Listing
December 2018
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Efficacy and safety of steroid in the prevention of esophageal stricture after endoscopic submucosal dissection: A network meta-analysis.

J Gastroenterol Hepatol 2018 Dec 19. Epub 2018 Dec 19.

Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Background And Aim: Even though endoscopic submucosal dissection is an important endoscopic resection technique for gastrointestinal neoplasms, there are chances that postoperative esophageal stricture might take place as a side effect. Steroid applications were reported to be effective for the prevention of stricture formation. Therefore, this study aims to evaluate the efficacy and safety of different steroid applications. Read More

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http://doi.wiley.com/10.1111/jgh.14580
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http://dx.doi.org/10.1111/jgh.14580DOI Listing
December 2018
14 Reads