4,442 results match your criteria Journal of Gastroenterology[Journal]


A Helicobacter pylori screening and treatment program to eliminate gastric cancer among junior high school students in Saga Prefecture: a preliminary report.

J Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga-shi, 849-8501, Saga, Japan.

Background: To present the strategies and preliminary findings of the first 3 years after implementing a Helicobacter pylori screening and eradication program to prevent gastric cancer in Saga Prefecture.

Methods: A screening and treatment program to eradicate H. pylori from third-grade junior high students was started in Saga Prefecture in 2016, using local governmental grants. Read More

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http://dx.doi.org/10.1007/s00535-019-01559-9DOI Listing
February 2019

Metachronous gastric cancer risk after endoscopic resection of early gastric cancer and H. pylori status.

Authors:
Mototsugu Kato

J Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

National Hospital Organization, Hakodate Hospital, Hakodate, Japan.

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http://dx.doi.org/10.1007/s00535-019-01560-2DOI Listing
February 2019

Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center.

J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Division of Gastroenterology, Department of Gastroenterology, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo, 663-8501, Japan.

Over almost 30 years since functional dyspepsia (FD) was defined, researchers have endeavored to elucidate the pathophysiology of functional gastrointestinal disorders. Now a consensus is emerging that the gastric symptoms of FD are caused mainly by gastric motility abnormalities and gastric hypersensitivity. The involvement of other causative factors including acid, Helicobacter pylori, psychological factors, and diet has been debated, but how they are involved in the manifestation of dyspeptic symptoms remains unclear. Read More

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http://dx.doi.org/10.1007/s00535-019-01550-4DOI Listing
February 2019

Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Hepatocellular carcinoma (HCC) recurrently develops in cirrhotic liver containing a number of regenerative nodules (RNs). However, the biological tumorigenic potential of RNs is still unclear. To uncover the molecular bases of tumorigenesis in liver cirrhosis, we investigated the genetic aberrations in RNs of cirrhotic tissues using next-generation sequencing. Read More

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http://dx.doi.org/10.1007/s00535-019-01555-zDOI Listing
February 2019

Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.

J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most intractable cancers, so the development of novel therapeutics has been required to improve patient outcomes. Curcumin, a polyphenol from Curcuma longa, exhibits various health benefits including antitumor effects, but its clinical utility is limited because of low bioavailability. Theracurmin (THC) is a highly bioavailable curcumin dispersed with colloidal submicron particles. Read More

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http://link.springer.com/10.1007/s00535-019-01549-x
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http://dx.doi.org/10.1007/s00535-019-01549-xDOI Listing
February 2019
1 Read

Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis.

J Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: Nonalcoholic steatohepatitis (NASH) is associated with liver inflammation in patients with nonalcoholic fatty liver disease, and it can progress to liver fibrosis at an advanced stage, as well as hepatocellular carcinoma (HCC) and portal hypertension. Although liver fibrosis is accurately diagnosed via biopsy, noninvasive methods are preferable. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with HCC and is secreted into the blood by liver cells via a lysosome-mediated nonclassical pathway. Read More

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http://link.springer.com/10.1007/s00535-019-01551-3
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http://dx.doi.org/10.1007/s00535-019-01551-3DOI Listing
February 2019
4 Reads

Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice.

J Gastroenterol 2019 Jan 25. Epub 2019 Jan 25.

Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: The emergence of a deletion mutant at hepatitis C virus (HCV) NS5A-P32 (P32del) has recently been reported in a subset of chronic hepatitis C patients who experience virologic failure after direct-acting antiviral drug (DAA) treatment. This mutation confers extremely high resistance to NS5A inhibitors. No effective treatment has been established for cases with this mutation. Read More

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http://dx.doi.org/10.1007/s00535-018-01541-xDOI Listing
January 2019
2 Reads

Liver disease in adults with severe alpha-1-antitrypsin deficiency.

J Gastroenterol 2019 Jan 24. Epub 2019 Jan 24.

Department of Respiratory Medicine and Allergology Malmö, Skåne University Hospital, Lund University, Jan Waldenströms gata 24, plan 4, 205 02, Malmö, Sweden.

Background: The proportion of adults with liver disease due to severe alpha-1-antitrypsin deficiency (AATD), with PiZZ phenotype, is not clear. The markers of the AATD liver disease, how it progresses, and measures for its prevention have not been established. The aim of this study was to analyze the risk of liver disease in individuals with severe AAT deficiency (PiZZ). Read More

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http://link.springer.com/10.1007/s00535-019-01548-y
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http://dx.doi.org/10.1007/s00535-019-01548-yDOI Listing
January 2019
7 Reads

Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study.

J Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Department of Laboratory Medicine, The Jikei University Daisan Hospital, 4-11-1, Izumihon-Cho, Komae-City, Tokyo, 201-8601, Japan.

Background And Aim: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) are frequently overlapped. However, no treatment strategies have been established yet for such patients. This study compared the effects of proton pump inhibitor (PPI) treatment in patients with GERD-associated FD among three groups with varying severity levels of GERD symptoms. Read More

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http://dx.doi.org/10.1007/s00535-019-01546-0DOI Listing
January 2019
1 Read

Molecular subtype switching in early-stage gastric cancers with multiple occurrences.

J Gastroenterol 2019 Jan 21. Epub 2019 Jan 21.

Department of Gastroenterology, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi, Japan.

Background: Multiple gastric cancers at the same time (synchronous) or recurrence after 1 year (metachronous) are frequently encountered. Since their genetic profiles were not well elucidated, we molecularly subtyped the genetic events of synchronous and metachronous early-stage gastric cancers.

Methods: We studied mismatch repair (MMR) genes in 84 tumors from 31 patients (15 synchronous and 16 metachronous) by immunohistochemistry. Read More

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http://link.springer.com/10.1007/s00535-019-01547-z
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http://dx.doi.org/10.1007/s00535-019-01547-zDOI Listing
January 2019
2 Reads

Efficacy and safety of a crystalline lactulose preparation (SK-1202) in Japanese patients with chronic constipation: a randomized, double-blind, placebo-controlled, dose-finding study.

J Gastroenterol 2019 Jan 14. Epub 2019 Jan 14.

Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Clinical evidence of lactulose for chronic constipation in Japan was lacking. We performed a randomized, double-blind, placebo-controlled, dose-finding study in Japanese patients with chronic constipation to estimate the optimal clinical dose of lactulose.

Methods: Overall, 250 patients were randomized to receive SK-1202 (13, 26, or 39 g/day, as crystalline lactulose dosage) or placebo twice daily (morning and evening) orally for 2 weeks. Read More

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http://dx.doi.org/10.1007/s00535-018-01545-7DOI Listing
January 2019

Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science.

J Gastroenterol 2019 Jan 14. Epub 2019 Jan 14.

Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA.

Alcohol and high-fat diet are two major risk factors responsible for metabolic diseases, which are manifested as steatohepatitis and liver cancer in the liver, and chronic pancreatitis and pancreatic adenocarcinoma (PDAC) in the pancreas. These metabolic diseases are becoming increasingly prevalent around the globe, and more importantly, their two major etiologies commonly coexist to precipitate the disease processes. To highlight the importance of these metabolic diseases, Japanese Society of Gastroenterology (JSGE) and National Institute on Alcoholism and Alcohol Abuse of National Institute of Health cosponsored the JSGE's 7th International Forum jointly held with the 12th International Symposium on ALPD and Cirrhosis. Read More

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http://link.springer.com/10.1007/s00535-018-01542-w
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http://dx.doi.org/10.1007/s00535-018-01542-wDOI Listing
January 2019
4 Reads

NS5A-P32 deletion as a factor involved in virologic failure in patients receiving glecaprevir and pibrentasvir.

J Gastroenterol 2019 Jan 5. Epub 2019 Jan 5.

Department of Gastroenterology & Hepatology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-cho, Iruma-Gun, Saitama, 350-0495, Japan.

Background: This study sought to clarify the factors involved in virologic failure in patients with HCV receiving retreatment with glecaprevir/pibrentasvir (GLE/PIB) in real-world practice.

Methods: Forty-two patients who had previously received direct-acting antivirals (DAAs) therapies consisting of 35, 3, 3, and 1 patient(s) with genotype (GT)-1b, GT-2a, GT-2b, and GT-3b HCV, respectively, received GLE/PIB for 12 weeks. Resistance-associated substitutions (RASs) at baseline were evaluated, and the dynamics of NS5A-RASs were assessed by deep sequencing in patients showing virologic failure. Read More

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http://dx.doi.org/10.1007/s00535-018-01543-9DOI Listing
January 2019

Marked impact of tumor location on the appropriate cutoff values and the prognostic significance of the lymph node ratio in stage III colon cancer: a multi-institutional retrospective analysis.

J Gastroenterol 2019 Jan 1. Epub 2019 Jan 1.

Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Background: The prognostic significance of lymph node ratio (LNR) is not constant among studies. Exploration of appropriate location-specific cutoffs might be necessary because the number of lymph nodes harvested is generally higher in right than in left colon cancer. We aimed to determine appropriate cutoff values of LNR in right and left colon cancer and to clarify its clinical significance. Read More

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http://link.springer.com/10.1007/s00535-018-01539-5
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http://dx.doi.org/10.1007/s00535-018-01539-5DOI Listing
January 2019
6 Reads

Epidemiological analysis of achalasia in Japan using a large-scale claims database.

J Gastroenterol 2019 Jan 3. Epub 2019 Jan 3.

Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, 757-1, Asahimachidori, Chuo-ku, Niigata, Niigata, 951-8510, Japan.

Background: Achalasia is a well-known esophageal motility disorder, but epidemiological studies in Japan are lacking. We investigated the incidence and period prevalence of achalasia in Japan, including the rate of coexistence of esophageal carcinoma, and evaluated treatment trends.

Methods: To estimate the nationwide number of patients with achalasia, a large-scale insurance claims database from 2005 to 2017 were used for our analyses. Read More

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http://link.springer.com/10.1007/s00535-018-01544-8
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http://dx.doi.org/10.1007/s00535-018-01544-8DOI Listing
January 2019
6 Reads

Feasibility of a simplified narrow-band imaging classification system for Barrett's esophagus for novice endoscopists.

J Gastroenterol 2019 Jan 2. Epub 2019 Jan 2.

National Hospital Organization Hakodate Hospital, Hakodate, Japan.

Background: Narrow-band imaging (NBI) classifications for Barrett's esophagus have been proposed for the detection of early esophageal adenocarcinoma. We developed a simplified classification system with demonstrated high diagnostic accuracy and reproducibility among experienced endoscopists, but the feasibility of this system among novice endoscopists was unclear.

Methods: In the present study, eight novice endoscopists with no experience of magnification endoscopy were asked to review 248 images of Barrett's esophagus (72 dysplastic, 176 non-dysplastic) obtained using high-definition magnification endoscopy with NBI 6 weeks before (1st test), immediately after (2nd test), and 6 weeks after (3rd test) being taught the simplified classification system. Read More

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http://dx.doi.org/10.1007/s00535-018-01537-7DOI Listing
January 2019
10 Reads

Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids.

J Gastroenterol 2019 Jan 1. Epub 2019 Jan 1.

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Background: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with an intractable, recurrent course. The goal of UC therapy is to target mucosal healing because immune-suppressive therapy for UC frequently results in relapse. However, few drugs directly target mucosal healing. Read More

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http://dx.doi.org/10.1007/s00535-018-01540-yDOI Listing
January 2019

Long-awaited treatment for hepatitis C virus decompensated cirrhosis.

Authors:
Kiminori Kimura

J Gastroenterol 2019 Jan 1. Epub 2019 Jan 1.

Department of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

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http://dx.doi.org/10.1007/s00535-018-01538-6DOI Listing
January 2019

Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice.

J Gastroenterol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi, China.

Background: The gut is implicated in the pathogenesis of acute pancreatitis (AP) and the infectious complications of AP are commonly associated with enteric bacteria, yet whether gut microbiota dysbiosis participants in AP severity remains largely unknown.

Methods: We collected clinical information and fecal samples from 165 adult participants, including 41 with mild AP (MAP), 59 with moderately severe AP (MSAP), 30 with severe AP (SAP) and 35 healthy controls (HC). The serum inflammatory cytokines and gut barrier indexes were detected. Read More

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http://dx.doi.org/10.1007/s00535-018-1529-0DOI Listing
December 2018
4 Reads

Usefulness of transabdominal ultrasonography for assessing ulcerative colitis: a prospective, multicenter study.

J Gastroenterol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7 Kita-ku, Sapporo, 060-8638, Japan.

Background: Transabdominal ultrasonography (US) has been reported to be a useful tool for evaluating ulcerative colitis (UC) although with less well-established data than for Crohn's disease. This prospective multicenter study aimed to establish the usefulness of US compared with colonoscopy (CS) for assessing disease extent and activity of UC.

Methods: Altogether, 173 patients with UC were prospectively enrolled, among whom 156 were eligible for this study. Read More

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http://dx.doi.org/10.1007/s00535-018-01534-wDOI Listing
December 2018
5 Reads

Independent and additive effects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma.

J Gastroenterol 2018 Nov 30. Epub 2018 Nov 30.

Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: This study was aimed at evaluating the association between single nucleotide polymorphisms (SNPs) in the PNPLA3, NCAN, TM6SF2 and MBOAT7 and hepatocellular carcinoma (HCC) development in Thai patients according to underlying etiologies of liver disease.

Methods: These SNPs were determined by allelic discrimination in blood samples of 105 healthy controls and 530 patients with HCC [270 with hepatitis B virus (HBV-HCC), 131 with hepatitis C virus (HCV-HCC), and 129 with non-B, non-C HCC (NBNC-HCC) matched for age and gender].

Results: G allele of PNPLA3 rs738409 variant was significantly higher in NBNC-HCC (49%) compared to healthy controls (32%), HBV-HCC (32%) and HCV-HCC (31%) (P < 0. Read More

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http://dx.doi.org/10.1007/s00535-018-01533-xDOI Listing
November 2018
4.523 Impact Factor

Pancreatic cancer arising from the remnant pancreas after pancreatectomy: a multicenter retrospective study by the Kyushu Study Group of Clinical Cancer.

J Gastroenterol 2018 Dec 4. Epub 2018 Dec 4.

Department of Surgery and Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: After initial pancreatic resection, local recurrence of pancreatic cancer (PC) or new primary PC can develop in the remnant. There are limited data available regarding this so-called remnant PC. The aim of this retrospective study was to clarify the clinical features and establish a treatment strategy for remnant PC. Read More

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http://dx.doi.org/10.1007/s00535-018-01535-9DOI Listing
December 2018
5 Reads

A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update.

J Gastroenterol 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Background: We previously reported that the incidence of hepatocellular carcinoma (HCC) with non-viral etiologies increased rapidly between 1991 and 2010 in Japan.

Methods: To update this investigation, we enrolled patients who were initially diagnosed as having non-B, non-C HCC at participating hospitals between 2011 and 2015. In addition to the patient characteristics investigated in the previous report, we also investigated the duration of alcohol consumption. Read More

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http://dx.doi.org/10.1007/s00535-018-1532-5DOI Listing
November 2018
3 Reads

Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease.

J Gastroenterol 2019 Feb 26;54(2):149-159. Epub 2018 Nov 26.

Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, 520-2192, Japan.

Background And Aims: There are no previous reports describing the fecal fungal microbiome of a Japanese population using advanced molecular techniques. In this study, we performed a molecular analysis on the fungal microbial community of a healthy Japanese population and patients with inflammatory bowel diseases (IBDs).

Patients And Methods: Fecal samples were obtained from 18 patients with inactive ulcerative colitis (UC, n = 18), Crohn's disease (CD, n = 20) and healthy volunteers (n = 20). Read More

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http://dx.doi.org/10.1007/s00535-018-1530-7DOI Listing
February 2019
2 Reads

Fluid sequestration is a useful parameter in the early identification of severe disease of acute pancreatitis.

J Gastroenterol 2018 Nov 26. Epub 2018 Nov 26.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Early identification of severe disease of acute pancreatitis (AP) is of critical importance to improve the prognosis. Fluid sequestration (FS), calculated from administrated fluid and fluid output, is a simple prognostic parameter. We examined its utility in the early phase of AP. Read More

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http://dx.doi.org/10.1007/s00535-018-1531-6DOI Listing
November 2018
1 Read

Advanced assessment of serum Mac-2 binding protein glycosylation isomer in patients with biliary atresia.

J Gastroenterol 2019 Feb 9;54(2):204-205. Epub 2018 Nov 9.

Department of Transplant Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

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http://link.springer.com/10.1007/s00535-018-1523-6
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http://dx.doi.org/10.1007/s00535-018-1523-6DOI Listing
February 2019
6 Reads

Short- and long-term outcomes of endoscopic submucosal dissection for early gastric cancer in the remnant stomach after gastrectomy.

J Gastroenterol 2018 Nov 9. Epub 2018 Nov 9.

Division of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.

Background: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in the remnant stomach is a minimally invasive treatment. Few studies compared the technical difficulty of ESD involving the suture line and anastomosis, and information on long-term outcomes is insufficient. This study aimed to elucidate the short- and long-term outcomes of ESD for EGC in the remnant stomach. Read More

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http://link.springer.com/10.1007/s00535-018-1528-1
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http://dx.doi.org/10.1007/s00535-018-1528-1DOI Listing
November 2018
7 Reads

Diagnostic efficacy of dual-focus endoscopy with narrow-band imaging using simplified dyad criteria for superficial esophageal squamous cell carcinoma.

J Gastroenterol 2018 Nov 8. Epub 2018 Nov 8.

Department of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine, Tokyo, Japan.

Background: Our previous studies have shown the diagnostic utility of a newly developed dual-focus endoscope with narrow-band imaging (DF-NBI) and simplified dyad criteria for detection of superficial esophageal squamous cell carcinoma (SESCC). This clinical trial aimed to study the diagnostic efficacy of DF-NBI with dyad criteria for detecting SESCC compared to white light imaging (WLI).

Methods: This was a single-arm prospective comparative trial. Read More

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http://link.springer.com/10.1007/s00535-018-1527-2
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http://dx.doi.org/10.1007/s00535-018-1527-2DOI Listing
November 2018
8 Reads

Impact of endoscopic ultrasonography on diagnosis of pancreatic cancer.

J Gastroenterol 2019 Jan 7;54(1):19-32. Epub 2018 Nov 7.

Department of Gastroenterology, Wakayama Medical University School of Medicine, 811-1 Kimiidera, Wakayama-City, Wakayama, 641-0012, Japan.

Accumulated evidence has revealed that endoscopic ultrasonography (EUS) has had a great impact on the clinical evaluation of pancreatic cancers. EUS can provide high-resolution images of the pancreas with a quality regarded as far surpassing that achieved on transabdominal ultrasound (US), computed tomography (CT), or magnetic resonance imaging (MRI). EUS is particularly useful for the detection of small pancreatic lesions, while EUS and its related techniques such as contrast-enhanced EUS (CE-EUS), EUS elastography, and EUS-guided fine needle aspiration (EUS-FNA) are also useful in the differential diagnosis of solid or cystic pancreatic lesions and the staging (T-staging, N-staging, and M-staging) of pancreatic cancers. Read More

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http://link.springer.com/10.1007/s00535-018-1519-2
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http://dx.doi.org/10.1007/s00535-018-1519-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314985PMC
January 2019
12 Reads

Antimicrobial proteins: intestinal guards to protect against liver disease.

J Gastroenterol 2018 Nov 3. Epub 2018 Nov 3.

Department of Medicine, University of California San Diego, La Jolla, CA, USA.

Alterations of gut microbes play a role in the pathogenesis and progression of many disorders including liver and gastrointestinal diseases. Both qualitative and quantitative changes in gut microbiota have been associated with liver disease. Intestinal dysbiosis can disrupt the integrity of the intestinal barrier leading to pathological bacterial translocation and the initiation of an inflammatory response in the liver. Read More

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http://link.springer.com/10.1007/s00535-018-1521-8
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http://dx.doi.org/10.1007/s00535-018-1521-8DOI Listing
November 2018
9 Reads

Deletion of IPR1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality.

J Gastroenterol 2018 Oct 31. Epub 2018 Oct 31.

Drug Discovery Center, State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.

Background: Inositol 1,4,5-trisphosphate receptors (IPRs) are a family of intracellular Ca release channels located on the membrane of endoplasmic reticulum, which have been shown to play critical roles in various cellular and physiological functions. However, their function in regulating gastrointestinal (GI) tract motility in vivo remains unknown. Here, we investigated the physiological function of IPR1 in the GI tract using genetically engineered mouse models. Read More

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http://link.springer.com/10.1007/s00535-018-1522-7
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http://dx.doi.org/10.1007/s00535-018-1522-7DOI Listing
October 2018
3 Reads

TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus by interferon-free therapy.

J Gastroenterol 2018 Oct 31. Epub 2018 Oct 31.

Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.

Background: The aim of this study is to ascertain whether the TLL1 variant at rs17047200 is associated with the development of HCC after achieving sustained virological response (SVR) by interferon (IFN)-free therapy for chronic hepatitis C (CHC).

Methods: A total of 1029 Japanese CHC patients with the following inclusion criteria were enrolled: (i) achieved SVR by IFN-free therapy, (ii) followed up at least 1 year from the end of treatment (EOT) (median 104 weeks), (iii) no history of hepatocellular carcinoma (HCC) by 1 year from the EOT.

Results: Nineteen patients developed HCC (HCC group) and 1010 did not (non-HCC group). Read More

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http://link.springer.com/10.1007/s00535-018-1526-3
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http://dx.doi.org/10.1007/s00535-018-1526-3DOI Listing
October 2018
3 Reads

A multicenter observational study on the clinicopathological features of gastric cancer in young patients.

J Gastroenterol 2018 Oct 29. Epub 2018 Oct 29.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: The details of gastric cancer in young patients remain unclear because of the low prevalence of the disease. This study aimed to clarify the clinicopathological features and prognosis of gastric cancer in young patients.

Methods: From January 2007 to January 2016, patients in their 20s and 30s who were diagnosed with primary gastric cancer at 4 hospitals were enrolled. Read More

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http://link.springer.com/10.1007/s00535-018-1525-4
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http://dx.doi.org/10.1007/s00535-018-1525-4DOI Listing
October 2018
5 Reads

Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures.

J Gastroenterol 2018 Oct 17. Epub 2018 Oct 17.

Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Background: Combination therapy with glecaprevir (GLE) and pibrentasvir (PIB) has high efficacy for pan-genotypic hepatitis C virus (HCV)-infected patients. However, the efficacy of the therapy for failures to prior direct-acting antiviral (DAA) regimens in real-world practice is not well known.

Methods: Thirty patients infected with HCV genotype 1b, 2a, 2b, or 3a who failed to respond during prior DAA therapies were treated with GLE/PIB for 12 weeks. Read More

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http://dx.doi.org/10.1007/s00535-018-1520-9DOI Listing
October 2018
1 Read

Sequential H. pylori eradication and radiation therapy with reduced dose compared to standard dose for gastric MALT lymphoma stages IE & II1E: a prospective randomized trial.

J Gastroenterol 2018 Oct 16. Epub 2018 Oct 16.

University Hospital Hamburg-Eppendorf, Center for Oncology and University Cancer Center Hamburg (UCCH), Hamburg, Germany.

Background: In Helicobacter pylori (H. pylori) positive stage I gastric low-grade MALT lymphoma, eradication is the accepted first-line therapy. The role of eradication therapy in lymphoma > stage IE is still unclear. Read More

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http://dx.doi.org/10.1007/s00535-018-1517-4DOI Listing
October 2018

Predictive factors of the treatment outcome in patients with advanced biliary tract cancer receiving gemcitabine plus cisplatin as first-line chemotherapy.

J Gastroenterol 2018 Oct 8. Epub 2018 Oct 8.

Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-8577, Japan.

Background: Few studies have clearly identified the prognostic factors in patients with advanced biliary tract cancer (BTC) receiving gemcitabine plus cisplatin (GC) which is acknowledged as standard chemotherapy regimen.

Objectives: The aim of this study was to identify predictive factors of the overall survival (OS) in advanced BTC patients receiving GC therapy.

Methods: Data of 307 patients with advanced BTC who received GC therapy as the first-line chemotherapy at our institution from January 2007 to June 2017 were reviewed retrospectively. Read More

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http://link.springer.com/10.1007/s00535-018-1518-3
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http://dx.doi.org/10.1007/s00535-018-1518-3DOI Listing
October 2018
1 Read

Linked color imaging can enhance recognition of early gastric cancer by high color contrast to surrounding gastric intestinal metaplasia.

J Gastroenterol 2018 Oct 5. Epub 2018 Oct 5.

Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Background: Linked color imaging (LCI) increases the visibility of early gastric cancers, which may be associated with characteristic findings including background purple mucosae. These lesions are found in areas of chronic gastritis and surrounding mucosa. The aim of this study is to objectively characterize these lesions by color differences and color component values using LCI. Read More

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http://dx.doi.org/10.1007/s00535-018-1515-6DOI Listing
October 2018
1 Read

Clinical significance of hepatic steatosis according to coronary plaque morphology: assessment using controlled attenuation parameter.

J Gastroenterol 2018 Oct 4. Epub 2018 Oct 4.

Division of Gastroenterology, Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, 39FL. Gangnam Finance Center 737, Yeoksam-Dong, Gangnam-Gu, Seoul, 135-984, Korea.

Background: Nonalcoholic fatty liver disease (NAFLD) plays a significant role in coronary atherosclerosis, independent of shared metabolic risk factors. The measurement of the controlled attenuation parameter (CAP) has shown to allow early and noninvasive detection of NAFLD at subclinical stage. We evaluated the significance of CAP-defined NAFLD in association with the presence of any type of coronary plaques and different plaque compositions. Read More

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http://link.springer.com/10.1007/s00535-018-1516-5
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http://dx.doi.org/10.1007/s00535-018-1516-5DOI Listing
October 2018
7 Reads

Detection of gastritis by a deep convolutional neural network from double-contrast upper gastrointestinal barium X-ray radiography.

J Gastroenterol 2018 Oct 3. Epub 2018 Oct 3.

Graduate School of Information Science and Technology, Hokkaido University, N-14, W-9, Kita-ku, Sapporo, Hokkaido, 060-0814, Japan.

Background: Deep learning has become a new trend of image recognition tasks in the field of medicine. We developed an automated gastritis detection system using double-contrast upper gastrointestinal barium X-ray radiography.

Methods: A total of 6520 gastric X-ray images obtained from 815 subjects were analyzed. Read More

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http://link.springer.com/10.1007/s00535-018-1514-7
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http://dx.doi.org/10.1007/s00535-018-1514-7DOI Listing
October 2018
16 Reads

Helicobacter pylori status and risks of metachronous recurrence after endoscopic resection of early gastric cancer: a systematic review and meta-analysis.

J Gastroenterol 2018 Sep 24. Epub 2018 Sep 24.

Department of Gastroenterology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China.

The impact of different Helicobacter pylori (H. pylori) status (H. pylori negative, H. Read More

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http://dx.doi.org/10.1007/s00535-018-1513-8DOI Listing
September 2018

Progress in characterizing the linkage between Fusobacterium nucleatum and gastrointestinal cancer.

J Gastroenterol 2019 Jan 22;54(1):33-41. Epub 2018 Sep 22.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Microbiome research is a rapidly advancing field in human cancers. Fusobacterium nucleatum is an oral bacterium, indigenous to the human oral cavity, that plays a role in periodontal disease. Recent studies have found that F. Read More

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http://dx.doi.org/10.1007/s00535-018-1512-9DOI Listing
January 2019
1 Read

Anti-tumor necrosis factor therapy decreases the risk of initial intestinal surgery after diagnosis of Crohn's disease of inflammatory type.

J Gastroenterol 2018 Sep 22. Epub 2018 Sep 22.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Anti-tumor necrosis factor (TNF) therapy induces and maintains clinical remission in patients with Crohn's disease (CD). However, the effect of anti-TNF therapy on the natural course of CD remains controversial. We aimed to investigate the effect of anti-TNF therapy on the initial intestinal surgery for CD. Read More

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http://dx.doi.org/10.1007/s00535-018-1511-xDOI Listing
September 2018
1 Read

Tumor-specific genetic aberrations in cell-free DNA of gastroesophageal cancer patients.

J Gastroenterol 2019 Feb 21;54(2):108-121. Epub 2018 Sep 21.

Department of Clinical Genetics, Odense University Hospital, J.B. Winsløws Vej 4, Odense, Denmark.

The applicability of liquid biopsies is studied intensively in all types of cancer and analysis of circulating tumor DNA (ctDNA) has recently been implemented clinically for mutation detection in lung cancer. ctDNA may provide information about tumor quantity and mutations present in the tumor, and as such have many potential applications in diagnosis and treatment of cancer. It has been suggested that ctDNA analysis may overcome the issue of intra-tumor heterogeneity faced by tissue biopsies and serve as an additional diagnostic tool. Read More

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http://link.springer.com/10.1007/s00535-018-1508-5
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http://dx.doi.org/10.1007/s00535-018-1508-5DOI Listing
February 2019
13 Reads

The role of small intestinal bacterial overgrowth in cystic fibrosis: a randomized case-controlled clinical trial with rifaximin.

J Gastroenterol 2018 Sep 19. Epub 2018 Sep 19.

Cystic Fibrosis Center, IRCCS G. Gaslini Institute, Genoa, Italy.

Background: Scientific literature shows a high prevalence of Small Intestinal Bacterial Overgrowth (SIBO) in patients with Cystic Fibrosis (CF). The role of SIBO in nutritional status and gastrointestinal symptoms in CF is not known. Our aim was to study epidemiology and clinical impact of SIBO while assessing the efficacy of rifaximin in eradicating SIBO in CF patients. Read More

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http://dx.doi.org/10.1007/s00535-018-1509-4DOI Listing
September 2018
4 Reads

Correction to: A case-control study of the risk of upper gastrointestinal mucosal injuries in patients prescribed concurrent NSAIDs and antithrombotic drugs based on data from the Japanese national claims database of 13 million accumulated patients.

J Gastroenterol 2018 Dec;53(12):1292-1293

Graduate School of Medical Science, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

The authors would like to correct the errors in the publication of the original article. The correction details are given below for your reading. Read More

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http://dx.doi.org/10.1007/s00535-018-1510-yDOI Listing
December 2018

Capsule endoscopy findings for the diagnosis of Crohn's disease: a nationwide case-control study.

J Gastroenterol 2018 Sep 15. Epub 2018 Sep 15.

Department of Internal Medicine, Toho University, Sakura Medical Centre, Sakura, Chiba, Japan.

Background: Capsule endoscopy can be used to identify the early stage of small bowel Crohn's disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD.

Methods: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD). Read More

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http://dx.doi.org/10.1007/s00535-018-1507-6DOI Listing
September 2018
4 Reads

Efficacy and safety of sofosbuvir-velpatasvir with or without ribavirin in HCV-infected Japanese patients with decompensated cirrhosis: an open-label phase 3 trial.

J Gastroenterol 2019 Jan 10;54(1):87-95. Epub 2018 Sep 10.

Musashino Red Cross Hospital, Tokyo, Japan.

Background: In Japan, hepatitis C virus (HCV)-infected patients with decompensated cirrhosis currently have no treatment options. In this Phase 3 study, we evaluated sofosbuvir-velpatasvir with or without ribavirin for 12 weeks in patients with any HCV genotype and decompensated cirrhosis [Child-Pugh-Turcotte (CPT) class B or C] in Japan.

Methods: Patients were randomized 1:1 to receive sofosbuvir-velpatasvir with or without ribavirin for 12 weeks. Read More

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http://dx.doi.org/10.1007/s00535-018-1503-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314981PMC
January 2019
4 Reads

Correction to: Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects.

J Gastroenterol 2019 Jan;54(1):96-98

Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

The authors would like to correct the errors in the publication of the original article. The correction details are given below for your reading. Read More

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http://dx.doi.org/10.1007/s00535-018-1504-9DOI Listing
January 2019
21 Reads

A single-arm, phase II trial of neoadjuvant gemcitabine and S1 in patients with resectable and borderline resectable pancreatic adenocarcinoma: PREP-01 study.

J Gastroenterol 2019 Feb 4;54(2):194-203. Epub 2018 Sep 4.

Department of Surgery, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Background: Neoadjuvant chemotherapy (NAC) represents a promising alternative to pancreatic ductal adenocarcinoma (PDAC) planned resection, but the survival impact remains undefined. To assess the feasibility and survival outcomes of NAC with gemcitabine and S1 (GS) for PDAC planned resection by prospective study.

Methods: Patients with resectable or borderline resectable PDAC received 2 cycles of NAC-GS and were offered curative resection followed by gemcitabine adjuvant. Read More

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http://link.springer.com/10.1007/s00535-018-1506-7
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http://dx.doi.org/10.1007/s00535-018-1506-7DOI Listing
February 2019
8 Reads