4,466 results match your criteria Journal of Gastroenterology[Journal]


Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma.

J Gastroenterol 2019 Apr 2. Epub 2019 Apr 2.

The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, 1-7-1, Kohnodai, Ichikawa, Chiba, 272-8516, Japan.

Background: Cancer-associated fibroblasts (CAFs) are essential constituents of cancer-supportive microenvironments. The high incidence of hepatocellular carcinoma (HCC) in advanced fibrosis patients implies that fibroblasts have a promoting effect on HCC development. We aimed to explore the regulators of phenotypes and function of CAFs in the liver. Read More

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http://dx.doi.org/10.1007/s00535-019-01579-5DOI Listing
April 2019
4 Reads

Relationship between esophageal motility abnormalities and skin or lung involvements in patients with systemic sclerosis.

J Gastroenterol 2019 Apr 1. Epub 2019 Apr 1.

Division of Gastroenterology and Hepatology, Integrative Center of Internal Medicine, Gunma University Hospital, Maebashi, Japan.

Background: Esophageal motility abnormalities (EMAs) and interstitial lung diseases (ILDs) are often seen in patients with systemic sclerosis (SSc). Gastroesophageal reflux disease (GERD) could be associated with ILDs, but it is not fully understood if ILDs are caused by GERD or SSc itself.

Methods: A total of 109 patients with SSc who underwent high-resolution manometry were enrolled. Read More

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http://dx.doi.org/10.1007/s00535-019-01578-6DOI Listing
April 2019
3 Reads

Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma.

J Gastroenterol 2019 Mar 29. Epub 2019 Mar 29.

Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.

Background: In Japan, the incidence of esophageal adenocarcinoma (EAC) and esophagogastric junction (EGJ) adenocarcinoma is expected to increase and that of gastric adenocarcinoma (GAC) is expected to decrease due to Westernization of the diet and the decreasing prevalence of Helicobacter pylori infection. However, few reports about these trends have included the latest data, and no reports about the time trend in the incidence of EGJ adenocarcinoma have focused on the etiologies (gastric cardia adenocarcinoma or EAC, including Barrett's adenocarcinoma). We therefore investigated the time trends in the incidence of these cancers by including the latest data. Read More

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http://dx.doi.org/10.1007/s00535-019-01577-7DOI Listing
March 2019
2 Reads

Genetic variants in RPA1 associated with the response to oxaliplatin-based chemotherapy in colorectal cancer.

J Gastroenterol 2019 Mar 28. Epub 2019 Mar 28.

Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.

Background: Oxaliplatin (L-OHP) is a commonly used first-line chemotherapy for colorectal cancer. Genetic variants in nucleotide excision repair (NER) pathway genes may alter genomic integrity and the efficacy of oxaliplatin-based chemotherapy in colorectal cancer.

Methods: We investigated the association between genetic variants in 19 NER pathway genes and the disease control rate (DCR) and progression-free survival (PFS) among 166 colorectal cancer patients who received oxaliplatin-based chemotherapy. Read More

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http://dx.doi.org/10.1007/s00535-019-01571-zDOI Listing

A new era for understanding genetic evolution of multistep carcinogenesis.

J Gastroenterol 2019 Mar 28. Epub 2019 Mar 28.

Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Cancer development is a multistep process involving genetic and cellular alterations, and recent advances in next-generation sequencing have elucidated mutation landscapes of premalignant lesions as well as early- and late-stage tumors. In this issue of Journal of Gastroenterology, Kim and colleagues contributed to the better understanding of genetic events in putative precursors of hepatocellular carcinoma (HCC). Precancerous tissues are divided into canonical and non-canonical types, which share common driver mutations with cancerous lesions or not, and potential gatekeeper gene(s) for clonal selection play a critical role in driving precursors to cancers not only in HCC, but also in esophageal, gastric, colorectal, and pancreatic cancers. Read More

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http://dx.doi.org/10.1007/s00535-019-01576-8DOI Listing
March 2019
1 Read

Systematic review with network meta-analysis: indirect comparison of the efficacy of vonoprazan and proton-pump inhibitors for maintenance treatment of gastroesophageal reflux disease.

J Gastroenterol 2019 Mar 27. Epub 2019 Mar 27.

Center for Medical Statistics, 2-9-6 Higashi Shimbashi, Minato-ku, Tokyo, 105-0021, Japan.

Background: Long-term maintenance treatment of gastroesophageal reflux disease (GERD) is important to prevent relapse. Proton-pump inhibitors (PPIs) are used for both treatment and maintenance therapy of GERD. Recently, a potassium-competitive acid blocker vonoprazan was launched in Japan. Read More

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http://dx.doi.org/10.1007/s00535-019-01572-yDOI Listing
March 2019
1 Read

Is the grade of ballooned hepatocytes a significant risk factor for rapid progression of hepatic fibrosis in patients with NAFLD?

J Gastroenterol 2019 May 26;54(5):474-475. Epub 2019 Mar 26.

Hepatology Center, Saiseikai Suita Hospital, Suita, Japan.

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http://dx.doi.org/10.1007/s00535-019-01573-xDOI Listing

Initial- and re-treatment effectiveness of glecaprevir and pibrentasvir for Japanese patients with chronic hepatitis C virus-genotype 1/2/3 infections.

J Gastroenterol 2019 Mar 22. Epub 2019 Mar 22.

Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan.

Background: Glecaprevir and pibrentasvir (GLE/PIB) are potent antiviral agents for hepatitis C virus (HCV) pan-genotypic infections; however, their clinical effectiveness and safety remain limited in the real-world. This study aimed to evaluate viral responses and the safety of GLE/PIB for patients with chronic HCV-1/2/3 infections during both initial- (Arm A) and re-treatment (Arm B) with all-oral direct-acting antiviral agents (DAAs).

Methods: This prospective-observational cohort study included Japanese patients with chronic HCV-1/2/3 infections (n = 271: 183 in Arm A and 83 in Arm B), who had started receiving GLE/PIB. Read More

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http://dx.doi.org/10.1007/s00535-019-01575-9DOI Listing
March 2019
2 Reads

Integrated analysis of 8-week glecaprevir/pibrentasvir in Japanese and overseas patients without cirrhosis and with hepatitis C virus genotype 1 or 2 infection.

J Gastroenterol 2019 Mar 13. Epub 2019 Mar 13.

Toranomon Hospital, Tokyo, Japan.

Background: Chronic hepatitis C virus (HCV) infection with genotypes (GT) 1 and 2 accounts for over 50% of HCV infections globally, including over 97% of all HCV infections in Japan. Here, we report an integrated analysis of efficacy and safety of 8-week treatment with the all-oral, fixed-dose combination of the direct acting antivirals (DAA), glecaprevir and pibrentasvir (G/P), in DAA-naïve Japanese and overseas patients without cirrhosis and with HCV GT1 or GT2 infection.

Methods: Data from 899 DAA-naïve patients without cirrhosis and with HCV GT1 or GT2 infection treated with G/P (300/120 mg) for 8 weeks in the six Phase 2 or 3 overseas or Japan-only clinical trials were included. Read More

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http://dx.doi.org/10.1007/s00535-019-01569-7DOI Listing
March 2019
2 Reads

A simple and practical index predicting the prognoses of the patients with well-differentiated pancreatic neuroendocrine neoplasms.

J Gastroenterol 2019 Mar 12. Epub 2019 Mar 12.

Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Background: The prognostic importance of the neuroendocrine (NE) markers involving neural cell adhesion molecule (NCAM) has been unclear enough to be adopted for WHO classification in patients with pancreatic neuroendocrine neoplasms (Pan-NENs). This study aimed to elucidate whether the three NE markers such as chromogranin A, synaptophysin, and NCAM decide prognoses for patients with well-differentiated tumors.

Methods: Between April 2002 and October 2018, 217 patients were included in this study. Read More

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http://dx.doi.org/10.1007/s00535-019-01570-0DOI Listing
March 2019
4 Reads

Correction to: Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study.

J Gastroenterol 2019 May;54(5):480-483

Department of Laboratory Medicine, The Jikei University Daisan Hospital, 4-11-1, Izumihon-Cho, Komae-City, Tokyo, 201-8601, Japan.

In the original publication of this article, Tables 2, 3, 4, 5 and 6 were published incorrectly. The correct tables are given below. Read More

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http://dx.doi.org/10.1007/s00535-019-01557-xDOI Listing
May 2019
2 Reads

Response to the letter by Matsushita et al. regarding our manuscript "Resection Depth and Layer of Cold Snare Polypectomy versus Endoscopic Mucosal Resection".

J Gastroenterol 2019 May 9;54(5):473. Epub 2019 Mar 9.

Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

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http://dx.doi.org/10.1007/s00535-019-01566-wDOI Listing

Meaningless comparison of resection depth between cold snare polypectomy and endoscopic mucosal resection.

J Gastroenterol 2019 May 9;54(5):471-472. Epub 2019 Mar 9.

Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.

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http://dx.doi.org/10.1007/s00535-019-01567-9DOI Listing

Real-world virological efficacy and safety of daclatasvir/asunaprevir/beclabuvir in patients with chronic hepatitis C virus genotype 1 infection in Japan.

J Gastroenterol 2019 Mar 8. Epub 2019 Mar 8.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Background: The virological efficacy and safety of the direct-acting antiviral (DAA) regimen consisting of daclatasvir, asunaprevir, and beclabuvir (DCV/ASV/BCV) for patients chronically infected with hepatitis C virus (HCV) genotype 1 have not been previously evaluated in Japanese real-world settings.

Methods: In a Japanese nationwide multicenter study, the rate of sustained virologic response (SVR) and safety were analyzed in 91 patients who started the DCV/ASV/BCV regimen between November 2016 and July 2017. SVR rates were compared based on baseline patient characteristics. Read More

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http://dx.doi.org/10.1007/s00535-019-01568-8DOI Listing
March 2019
1 Read

Noninvasive diagnostic criteria for nonalcoholic steatohepatitis based on gene expression levels in peripheral blood mononuclear cells.

J Gastroenterol 2019 Mar 4. Epub 2019 Mar 4.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Nonalcoholic fatty liver disease (NAFLD) consists of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH); the latter progresses to liver cirrhosis and hepatocellular carcinoma. Discriminating NASH from NAFL typically involves liver biopsy. The mechanism of NASH progression is unclear but may involve immunological pathways. Read More

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http://dx.doi.org/10.1007/s00535-019-01565-xDOI Listing
March 2019
1 Read
4.523 Impact Factor

Epstein-Barr virus status is a promising biomarker for endoscopic resection in early gastric cancer: proposal of a novel therapeutic strategy.

J Gastroenterol 2019 Mar 2. Epub 2019 Mar 2.

Department of Gastroenterology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research (JFCR), 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: Epstein-Barr virus-positive gastric cancer (EBVGC) is associated with a low prevalence of lymph node metastasis (LNM); however, EBV status is not considered in the indication of endoscopic resection (ER). We aimed to clarify the implication of EBV status for ER of pT1b GC.

Methods: Consecutive cases of pT1b GCs treated with surgery between 2005 and 2014 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s00535-019-01562-0DOI Listing
March 2019
1 Read

YAP and the Hippo pathway in cholangiocarcinoma.

J Gastroenterol 2019 Feb 27. Epub 2019 Feb 27.

Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN, 55905, USA.

Cholangiocarcinoma (CCA) has an increasing incidence and remains a difficult to treat malignancy. In a search for more effective treatment options, progress has been made in identifying molecular drivers of oncogenic signaling including IDH mutations and FGFR2 fusions. In addition, multiple investigators have identified increased activity of YAP, the effector protein of the Hippo pathway, in CCA. Read More

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http://dx.doi.org/10.1007/s00535-019-01563-zDOI Listing
February 2019
10 Reads

Pathological risk factors and predictive endoscopic factors for lymph node metastasis of T1 colorectal cancer: a single-center study of 846 lesions.

J Gastroenterol 2019 Feb 27. Epub 2019 Feb 27.

Department of Gastroenterology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: Determining the depth of invasion of early stage colorectal cancer has been emphasized as a means of improving endoscopic diagnostic accuracy. Recent studies have focused on other pathological risk factors for lymph node metastasis (LNM). We investigated the significance of depth of invasion and predictive properties of other endoscopic findings. Read More

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http://dx.doi.org/10.1007/s00535-019-01564-yDOI Listing
February 2019

Recent advancement in EUS-guided fine needle sampling.

J Gastroenterol 2019 May 26;54(5):377-387. Epub 2019 Feb 26.

Department of Gastroenterology and Hepatology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

EUS-guided tissue acquisition technique plays an essential role for evaluation of gastrointestinal tumors. Several components affect the yield of EUS-guided tissue acquisition outcomes such as sampling techniques, use of ROSE (rapid onsite evaluation), training and experience, and needle designs. In this review we discuss advancement in EUS-guided fine needle sampling. Read More

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http://dx.doi.org/10.1007/s00535-019-01552-2DOI Listing

Efficacy and safety of glecaprevir and pibrentasvir treatment for 8 or 12 weeks in patients with recurrent hepatitis C after liver transplantation: a Japanese multicenter experience.

J Gastroenterol 2019 Feb 26. Epub 2019 Feb 26.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Efficacy of 8-week regimen with direct-acting antivirals (DAA) for patients with hepatitis C after liver transplantation has not been clarified. This study aimed to clarify the efficacy and safety of glecaprevir and pibrentasvir therapy for 8 and 12 weeks in Japanese patients with recurrent hepatitis C after liver transplantation.

Methods: A cohort study of liver transplant recipients with recurrent hepatitis C treated with glecaprevir (300 mg/day) and pibrentasvir (120 mg/day) was performed at nine liver transplant centers in Japan. Read More

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http://dx.doi.org/10.1007/s00535-019-01561-1DOI Listing
February 2019
1 Read

Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice.

J Gastroenterol 2019 Feb 21. Epub 2019 Feb 21.

Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Background And Aims: The clinical course and responsiveness to antiviral treatments differs among hepatitis B virus (HBV) genotypes. However, the cause of these differences is unclear. In the present study, we compared mRNA expression profiles in human hepatocyte chimeric mice infected with HBV genotypes A and C. Read More

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http://link.springer.com/10.1007/s00535-019-01558-w
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http://dx.doi.org/10.1007/s00535-019-01558-wDOI Listing
February 2019
4 Reads
4.523 Impact Factor

Cost-effectiveness analysis of lenvatinib treatment for patients with unresectable hepatocellular carcinoma (uHCC) compared with sorafenib in Japan.

J Gastroenterol 2019 Feb 20. Epub 2019 Feb 20.

International University of Health and Welfare, Narita, Japan.

Background: Lenvatinib demonstrated a treatment effect on overall survival by the statistical confirmation of non-inferiority to sorafenib for the first-line treatment of uHCC. The objective of this study was to evaluate the cost-effectiveness of lenvatinib compared with sorafenib for patients with uHCC in Japan.

Methods: A partitioned-survival model was developed to estimate the cost-effectiveness of lenvatinib versus sorafenib when treating uHCC patients over a lifetime horizon and considering total public healthcare expenditure. Read More

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http://dx.doi.org/10.1007/s00535-019-01554-0DOI Listing
February 2019
1 Read

Safety and efficacy of glecaprevir and pibrentasvir in Japanese hemodialysis patients with genotype 2 hepatitis C virus infection.

J Gastroenterol 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, 060-8638, Hokkaido, Japan.

Background: Until recently, interferon-free anti-hepatitis C virus (HCV) therapy for genotype 2 (GT2) HCV-infected hemodialysis patients was an unfulfilled medical need. Recent clinical trials of glecaprevir and pibrentasvir (G/P) for hemodialysis patients showed high efficacy and safety; however, the number of GT2 HCV-infected patients, especially Asian patients, was limited and most of them were treated with a 12-week regimen. In this prospective multicenter study, we aimed to investigate the efficacy and safety of G/P in Japanese hemodialysis patients with GT2 HCV infection. Read More

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http://link.springer.com/10.1007/s00535-019-01556-y
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http://dx.doi.org/10.1007/s00535-019-01556-yDOI Listing
February 2019
4 Reads

A Helicobacter pylori screening and treatment program to eliminate gastric cancer among junior high school students in Saga Prefecture: a preliminary report.

J Gastroenterol 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga-shi, 849-8501, Saga, Japan.

Background: To present the strategies and preliminary findings of the first 3 years after implementing a Helicobacter pylori screening and eradication program to prevent gastric cancer in Saga Prefecture.

Methods: A screening and treatment program to eradicate H. pylori from third-grade junior high students was started in Saga Prefecture in 2016, using local governmental grants. Read More

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http://dx.doi.org/10.1007/s00535-019-01559-9DOI Listing
February 2019
2 Reads

Metachronous gastric cancer risk after endoscopic resection of early gastric cancer and H. pylori status.

Authors:
Mototsugu Kato

J Gastroenterol 2019 May 15;54(5):478-479. Epub 2019 Feb 15.

National Hospital Organization, Hakodate Hospital, Hakodate, Japan.

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http://dx.doi.org/10.1007/s00535-019-01560-2DOI Listing

Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center.

J Gastroenterol 2019 Apr 14;54(4):305-311. Epub 2019 Feb 14.

Division of Gastroenterology, Department of Gastroenterology, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo, 663-8501, Japan.

Over almost 30 years since functional dyspepsia (FD) was defined, researchers have endeavored to elucidate the pathophysiology of functional gastrointestinal disorders. Now a consensus is emerging that the gastric symptoms of FD are caused mainly by gastric motility abnormalities and gastric hypersensitivity. The involvement of other causative factors including acid, Helicobacter pylori, psychological factors, and diet has been debated, but how they are involved in the manifestation of dyspeptic symptoms remains unclear. Read More

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http://dx.doi.org/10.1007/s00535-019-01550-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437122PMC
April 2019
1 Read

Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.

J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Hepatocellular carcinoma (HCC) recurrently develops in cirrhotic liver containing a number of regenerative nodules (RNs). However, the biological tumorigenic potential of RNs is still unclear. To uncover the molecular bases of tumorigenesis in liver cirrhosis, we investigated the genetic aberrations in RNs of cirrhotic tissues using next-generation sequencing. Read More

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http://dx.doi.org/10.1007/s00535-019-01555-zDOI Listing
February 2019
1 Read

Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.

J Gastroenterol 2019 Feb 8. Epub 2019 Feb 8.

Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most intractable cancers, so the development of novel therapeutics has been required to improve patient outcomes. Curcumin, a polyphenol from Curcuma longa, exhibits various health benefits including antitumor effects, but its clinical utility is limited because of low bioavailability. Theracurmin (THC) is a highly bioavailable curcumin dispersed with colloidal submicron particles. Read More

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http://link.springer.com/10.1007/s00535-019-01549-x
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http://dx.doi.org/10.1007/s00535-019-01549-xDOI Listing
February 2019
7 Reads

Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis.

J Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: Nonalcoholic steatohepatitis (NASH) is associated with liver inflammation in patients with nonalcoholic fatty liver disease, and it can progress to liver fibrosis at an advanced stage, as well as hepatocellular carcinoma (HCC) and portal hypertension. Although liver fibrosis is accurately diagnosed via biopsy, noninvasive methods are preferable. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with HCC and is secreted into the blood by liver cells via a lysosome-mediated nonclassical pathway. Read More

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http://link.springer.com/10.1007/s00535-019-01551-3
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http://dx.doi.org/10.1007/s00535-019-01551-3DOI Listing
February 2019
10 Reads

Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice.

J Gastroenterol 2019 May 25;54(5):449-458. Epub 2019 Jan 25.

Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: The emergence of a deletion mutant at hepatitis C virus (HCV) NS5A-P32 (P32del) has recently been reported in a subset of chronic hepatitis C patients who experience virologic failure after direct-acting antiviral drug (DAA) treatment. This mutation confers extremely high resistance to NS5A inhibitors. No effective treatment has been established for cases with this mutation. Read More

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http://dx.doi.org/10.1007/s00535-018-01541-xDOI Listing
May 2019
3 Reads

Liver disease in adults with severe alpha-1-antitrypsin deficiency.

J Gastroenterol 2019 Jan 24. Epub 2019 Jan 24.

Department of Respiratory Medicine and Allergology Malmö, Skåne University Hospital, Lund University, Jan Waldenströms gata 24, plan 4, 205 02, Malmö, Sweden.

Background: The proportion of adults with liver disease due to severe alpha-1-antitrypsin deficiency (AATD), with PiZZ phenotype, is not clear. The markers of the AATD liver disease, how it progresses, and measures for its prevention have not been established. The aim of this study was to analyze the risk of liver disease in individuals with severe AAT deficiency (PiZZ). Read More

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http://link.springer.com/10.1007/s00535-019-01548-y
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http://dx.doi.org/10.1007/s00535-019-01548-yDOI Listing
January 2019
18 Reads

Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study.

J Gastroenterol 2019 Jan 23. Epub 2019 Jan 23.

Department of Laboratory Medicine, The Jikei University Daisan Hospital, 4-11-1, Izumihon-Cho, Komae-City, Tokyo, 201-8601, Japan.

Background And Aim: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) are frequently overlapped. However, no treatment strategies have been established yet for such patients. This study compared the effects of proton pump inhibitor (PPI) treatment in patients with GERD-associated FD among three groups with varying severity levels of GERD symptoms. Read More

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http://dx.doi.org/10.1007/s00535-019-01546-0DOI Listing
January 2019
6 Reads

Molecular subtype switching in early-stage gastric cancers with multiple occurrences.

J Gastroenterol 2019 Jan 21. Epub 2019 Jan 21.

Department of Gastroenterology, Yamanashi Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi, Japan.

Background: Multiple gastric cancers at the same time (synchronous) or recurrence after 1 year (metachronous) are frequently encountered. Since their genetic profiles were not well elucidated, we molecularly subtyped the genetic events of synchronous and metachronous early-stage gastric cancers.

Methods: We studied mismatch repair (MMR) genes in 84 tumors from 31 patients (15 synchronous and 16 metachronous) by immunohistochemistry. Read More

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http://link.springer.com/10.1007/s00535-019-01547-z
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http://dx.doi.org/10.1007/s00535-019-01547-zDOI Listing
January 2019
3 Reads

Efficacy and safety of a crystalline lactulose preparation (SK-1202) in Japanese patients with chronic constipation: a randomized, double-blind, placebo-controlled, dose-finding study.

J Gastroenterol 2019 Jan 14. Epub 2019 Jan 14.

Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Clinical evidence of lactulose for chronic constipation in Japan was lacking. We performed a randomized, double-blind, placebo-controlled, dose-finding study in Japanese patients with chronic constipation to estimate the optimal clinical dose of lactulose.

Methods: Overall, 250 patients were randomized to receive SK-1202 (13, 26, or 39 g/day, as crystalline lactulose dosage) or placebo twice daily (morning and evening) orally for 2 weeks. Read More

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http://dx.doi.org/10.1007/s00535-018-01545-7DOI Listing
January 2019
1 Read

Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science.

J Gastroenterol 2019 Mar 14;54(3):218-225. Epub 2019 Jan 14.

Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, MMR-402, Los Angeles, CA, 90033, USA.

Alcohol and high-fat diet are two major risk factors responsible for metabolic diseases, which are manifested as steatohepatitis and liver cancer in the liver, and chronic pancreatitis and pancreatic adenocarcinoma (PDAC) in the pancreas. These metabolic diseases are becoming increasingly prevalent around the globe, and more importantly, their two major etiologies commonly coexist to precipitate the disease processes. To highlight the importance of these metabolic diseases, Japanese Society of Gastroenterology (JSGE) and National Institute on Alcoholism and Alcohol Abuse of National Institute of Health cosponsored the JSGE's 7th International Forum jointly held with the 12th International Symposium on ALPD and Cirrhosis. Read More

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http://link.springer.com/10.1007/s00535-018-01542-w
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http://dx.doi.org/10.1007/s00535-018-01542-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394716PMC
March 2019
9 Reads

NS5A-P32 deletion as a factor involved in virologic failure in patients receiving glecaprevir and pibrentasvir.

J Gastroenterol 2019 May 5;54(5):459-470. Epub 2019 Jan 5.

Department of Gastroenterology & Hepatology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-cho, Iruma-Gun, Saitama, 350-0495, Japan.

Background: This study sought to clarify the factors involved in virologic failure in patients with HCV receiving retreatment with glecaprevir/pibrentasvir (GLE/PIB) in real-world practice.

Methods: Forty-two patients who had previously received direct-acting antivirals (DAAs) therapies consisting of 35, 3, 3, and 1 patient(s) with genotype (GT)-1b, GT-2a, GT-2b, and GT-3b HCV, respectively, received GLE/PIB for 12 weeks. Resistance-associated substitutions (RASs) at baseline were evaluated, and the dynamics of NS5A-RASs were assessed by deep sequencing in patients showing virologic failure. Read More

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http://dx.doi.org/10.1007/s00535-018-01543-9DOI Listing
May 2019
3 Reads

Marked impact of tumor location on the appropriate cutoff values and the prognostic significance of the lymph node ratio in stage III colon cancer: a multi-institutional retrospective analysis.

J Gastroenterol 2019 Jan 1. Epub 2019 Jan 1.

Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Background: The prognostic significance of lymph node ratio (LNR) is not constant among studies. Exploration of appropriate location-specific cutoffs might be necessary because the number of lymph nodes harvested is generally higher in right than in left colon cancer. We aimed to determine appropriate cutoff values of LNR in right and left colon cancer and to clarify its clinical significance. Read More

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http://link.springer.com/10.1007/s00535-018-01539-5
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http://dx.doi.org/10.1007/s00535-018-01539-5DOI Listing
January 2019
12 Reads

Epidemiological analysis of achalasia in Japan using a large-scale claims database.

J Gastroenterol 2019 Jan 3. Epub 2019 Jan 3.

Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, 757-1, Asahimachidori, Chuo-ku, Niigata, Niigata, 951-8510, Japan.

Background: Achalasia is a well-known esophageal motility disorder, but epidemiological studies in Japan are lacking. We investigated the incidence and period prevalence of achalasia in Japan, including the rate of coexistence of esophageal carcinoma, and evaluated treatment trends.

Methods: To estimate the nationwide number of patients with achalasia, a large-scale insurance claims database from 2005 to 2017 were used for our analyses. Read More

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http://link.springer.com/10.1007/s00535-018-01544-8
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http://dx.doi.org/10.1007/s00535-018-01544-8DOI Listing
January 2019
11 Reads

Feasibility of a simplified narrow-band imaging classification system for Barrett's esophagus for novice endoscopists.

J Gastroenterol 2019 Jan 2. Epub 2019 Jan 2.

National Hospital Organization Hakodate Hospital, Hakodate, Japan.

Background: Narrow-band imaging (NBI) classifications for Barrett's esophagus have been proposed for the detection of early esophageal adenocarcinoma. We developed a simplified classification system with demonstrated high diagnostic accuracy and reproducibility among experienced endoscopists, but the feasibility of this system among novice endoscopists was unclear.

Methods: In the present study, eight novice endoscopists with no experience of magnification endoscopy were asked to review 248 images of Barrett's esophagus (72 dysplastic, 176 non-dysplastic) obtained using high-definition magnification endoscopy with NBI 6 weeks before (1st test), immediately after (2nd test), and 6 weeks after (3rd test) being taught the simplified classification system. Read More

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http://dx.doi.org/10.1007/s00535-018-01537-7DOI Listing
January 2019
15 Reads

Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids.

J Gastroenterol 2019 Jan 1. Epub 2019 Jan 1.

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Background: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with an intractable, recurrent course. The goal of UC therapy is to target mucosal healing because immune-suppressive therapy for UC frequently results in relapse. However, few drugs directly target mucosal healing. Read More

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http://dx.doi.org/10.1007/s00535-018-01540-yDOI Listing
January 2019
2 Reads

Long-awaited treatment for hepatitis C virus decompensated cirrhosis.

Authors:
Kiminori Kimura

J Gastroenterol 2019 Mar 1;54(3):299-300. Epub 2019 Jan 1.

Department of Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

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http://dx.doi.org/10.1007/s00535-018-01538-6DOI Listing
March 2019
1 Read

Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice.

J Gastroenterol 2019 Apr 5;54(4):347-358. Epub 2018 Dec 5.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, 330006, Jiangxi, China.

Background: The gut is implicated in the pathogenesis of acute pancreatitis (AP) and the infectious complications of AP are commonly associated with enteric bacteria, yet whether gut microbiota dysbiosis participants in AP severity remains largely unknown.

Methods: We collected clinical information and fecal samples from 165 adult participants, including 41 with mild AP (MAP), 59 with moderately severe AP (MSAP), 30 with severe AP (SAP) and 35 healthy controls (HC). The serum inflammatory cytokines and gut barrier indexes were detected. Read More

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http://dx.doi.org/10.1007/s00535-018-1529-0DOI Listing
April 2019
7 Reads

Usefulness of transabdominal ultrasonography for assessing ulcerative colitis: a prospective, multicenter study.

J Gastroenterol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7 Kita-ku, Sapporo, 060-8638, Japan.

Background: Transabdominal ultrasonography (US) has been reported to be a useful tool for evaluating ulcerative colitis (UC) although with less well-established data than for Crohn's disease. This prospective multicenter study aimed to establish the usefulness of US compared with colonoscopy (CS) for assessing disease extent and activity of UC.

Methods: Altogether, 173 patients with UC were prospectively enrolled, among whom 156 were eligible for this study. Read More

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http://dx.doi.org/10.1007/s00535-018-01534-wDOI Listing
December 2018
14 Reads

Independent and additive effects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma.

J Gastroenterol 2019 May 30;54(5):427-436. Epub 2018 Nov 30.

Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: This study was aimed at evaluating the association between single nucleotide polymorphisms (SNPs) in the PNPLA3, NCAN, TM6SF2 and MBOAT7 and hepatocellular carcinoma (HCC) development in Thai patients according to underlying etiologies of liver disease.

Methods: These SNPs were determined by allelic discrimination in blood samples of 105 healthy controls and 530 patients with HCC [270 with hepatitis B virus (HBV-HCC), 131 with hepatitis C virus (HCV-HCC), and 129 with non-B, non-C HCC (NBNC-HCC) matched for age and gender].

Results: G allele of PNPLA3 rs738409 variant was significantly higher in NBNC-HCC (49%) compared to healthy controls (32%), HBV-HCC (32%) and HCV-HCC (31%) (P < 0. Read More

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http://dx.doi.org/10.1007/s00535-018-01533-xDOI Listing
May 2019
2 Reads
4.523 Impact Factor

Pancreatic cancer arising from the remnant pancreas after pancreatectomy: a multicenter retrospective study by the Kyushu Study Group of Clinical Cancer.

J Gastroenterol 2019 May 4;54(5):437-448. Epub 2018 Dec 4.

Department of Surgery and Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: After initial pancreatic resection, local recurrence of pancreatic cancer (PC) or new primary PC can develop in the remnant. There are limited data available regarding this so-called remnant PC. The aim of this retrospective study was to clarify the clinical features and establish a treatment strategy for remnant PC. Read More

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http://dx.doi.org/10.1007/s00535-018-01535-9DOI Listing
May 2019
14 Reads

A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update.

J Gastroenterol 2019 Apr 29;54(4):367-376. Epub 2018 Nov 29.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Background: We previously reported that the incidence of hepatocellular carcinoma (HCC) with non-viral etiologies increased rapidly between 1991 and 2010 in Japan.

Methods: To update this investigation, we enrolled patients who were initially diagnosed as having non-B, non-C HCC at participating hospitals between 2011 and 2015. In addition to the patient characteristics investigated in the previous report, we also investigated the duration of alcohol consumption. Read More

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http://dx.doi.org/10.1007/s00535-018-1532-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437291PMC
April 2019
10 Reads

Characterization of fungal dysbiosis in Japanese patients with inflammatory bowel disease.

J Gastroenterol 2019 Feb 26;54(2):149-159. Epub 2018 Nov 26.

Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, 520-2192, Japan.

Background And Aims: There are no previous reports describing the fecal fungal microbiome of a Japanese population using advanced molecular techniques. In this study, we performed a molecular analysis on the fungal microbial community of a healthy Japanese population and patients with inflammatory bowel diseases (IBDs).

Patients And Methods: Fecal samples were obtained from 18 patients with inactive ulcerative colitis (UC, n = 18), Crohn's disease (CD, n = 20) and healthy volunteers (n = 20). Read More

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http://dx.doi.org/10.1007/s00535-018-1530-7DOI Listing
February 2019
3 Reads

Fluid sequestration is a useful parameter in the early identification of severe disease of acute pancreatitis.

J Gastroenterol 2019 Apr 26;54(4):359-366. Epub 2018 Nov 26.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Early identification of severe disease of acute pancreatitis (AP) is of critical importance to improve the prognosis. Fluid sequestration (FS), calculated from administrated fluid and fluid output, is a simple prognostic parameter. We examined its utility in the early phase of AP. Read More

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http://dx.doi.org/10.1007/s00535-018-1531-6DOI Listing
April 2019
4 Reads