1,416,608 results match your criteria Journal of Experimental & Clinical Cancer Research [Journal]


[Experimental studies on the repair and restitution of cartilage by cartilage acellular extracellular matrix and adipose tissue-derived stem cells].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;54(2):133-138

Department of Ophthalmology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.

To investigate the effects of the repair and restitution of ear-shaped cartilage by adipose tissue-derived stem cells(ADSC) and cartilage acellular extracellular matrix. ADSC were extracted by digesting with collagenase type II from the adipose tissue from 32 patients with adiposity whose fats were drawn, and were cultured and subcultured in vitro. The natural biological scaffolds were prepared by acellular method using porcine ear cartilage, and then the second generation ADSC(5. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.02.007DOI Listing
February 2019

Robot-assisted Percutaneous Transfacet Screw Fixation Supplementing Oblique Lateral Interbody Fusion Procedure: Accuracy and Safety Evaluation of This Novel Minimally Invasive Technique.

Orthop Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing, China.

Objectives: Percutaneous transfacet screw fixation (pTSF) is a minimally invasive posterior fixation technique supplementing oblique lateral interbody fusion (OLIF) for lumbar spinal disorders. Accurate screw insertion is difficult to achieve and technically demanding under 2-D fluoroscopy. Recently developed robot-assisted spinal surgery demonstrated a high level of accuracy of pedicle screw insertion and a low complication rate. Read More

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http://dx.doi.org/10.1111/os.12428DOI Listing
February 2019

Changes and Challenges.

Hamostaseologie 2019 Feb 18;39(1):1-3. Epub 2019 Feb 18.

Division of Experimental and Clinical Hemostasis, Hemotherapy and Transfusion Medicine, and Hemophilia Comprehensive Care Center, Institute of Transplantation Diagnostics and Cell Therapy, Heinrich Heine University Medical Center, Düsseldorf, Germany.

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http://dx.doi.org/10.1055/s-0039-1678526DOI Listing
February 2019

Ion channel engineering for modulation and de novo generation of electrical excitability.

Curr Opin Biotechnol 2019 Feb 15;58:100-107. Epub 2019 Feb 15.

Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. Electronic address:

Ion channels play essential roles in regulating electrical properties of excitable tissues. By leveraging various ion channel gating mechanisms, scientists have developed a versatile set of genetically encoded tools to modulate intrinsic tissue excitability under different experimental settings. In this article, we will review how ion channels activated by voltage, light, small chemicals, stretch, and temperature have been customized to enable control of tissue excitability both in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.copbio.2019.01.004DOI Listing
February 2019

Clinical and neuroimaging features of the m.10197G>A mtDNA mutation: New case reports and expansion of the phenotype variability.

J Neurol Sci 2019 Feb 6;399:69-75. Epub 2019 Feb 6.

IRCCS Fondazione Stella Maris, viale del Tirreno 331, 56128 Calambrone, Pisa, Italy.

Complex I (CI) is the largest component of the mitochondrial respiratory chain (MRC) and it is made up of 7 mitochondrial DNA (mtDNA)-encoded and at least 38 nuclear DNA-encoded subunits. Isolated CI deficiency is the most common single enzyme deficiency in the heterogeneous group of MRC disorders and it is a relatively common etiology of Leigh-like syndrome (LS). With a few exceptions, descriptions of the clinical spectrum of specific mutations in CI are scarce. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.010DOI Listing
February 2019

Cytokines use different intracellular mechanisms to upregulate the membrane expression of CXCR1 in human monocytes.

Mol Immunol 2019 Feb 15;108:23-33. Epub 2019 Feb 15.

Laboratorio de Patogénesis e Inmunología de Procesos Infecciosos, Instituto de Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas- Academia Nacional de Medicina, Buenos Aires, Argentina. Electronic address:

Membrane expression of fractalkine (CXCL1)-receptor (CXCR1) is relevant in monocytes (Mo) because CXCR1-CXCL1 interactions might participate on both, homeostatic and pathologic conditions. We have previously demonstrated that CXCR1 levels are decreased during culture and when Mo are differentiated into dendritic cells, but enhanced when differentiated into macrophages. Regarding soluble factors, lipopolysaccharide (LPS) accelerated the loss of CXCR1, while interleukin (IL)-10 and Interferon-gamma (IFN-γ) prevented it. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.003DOI Listing
February 2019

Coumarin based hydrazone as an ICT-based fluorescence chemosensor for the detection of Cu ions and the application in HeLa cells.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 11;214:170-176. Epub 2019 Feb 11.

Department of Chemistry, Bharathiar University, Tamil Nadu, India.

We have constructed a new coumarin based fluorescence probe BENZPYR with ICT character through condensation of N, N-diethylamino-3-acetyl coumarin with 2-hydrazinobenzothiazole. The absorbance and fluorescence spectral characteristics of BENZPYR revealed that the chemosensor can specifically detect for Cu ions over other different metal ions and the lowest limit of detection was found in nano molar range. The turn off sensor of BENZPYR is related to chelation enhanced quenching (CHEQ) and intramolecular charge transfer (ICT) processes were serve as excellent fluorescent detection of Cu ions in DMF medium. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.020DOI Listing
February 2019

Autistic traits impact on olfactory processing in adolescent girls with Anorexia Nervosa restricting type.

Psychiatry Res 2019 Feb 11;274:20-26. Epub 2019 Feb 11.

IRCCS Fondazione Stella Maris, Pisa, Italy; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

The correct functioning of the chemosensory pathway is pivotal for the attitude towards feeding. In some neuropsychiatric disorders, abnormalities of the sensory processing dramatically affect feeding behavior; however, evidences for an olfactory involvement in Anorexia Nervosa (AN) are still controversial. We administered a complete olfactory testing battery, the Sniffin' Sticks Extended Test, to a cohort of 19 girls with Restrictive Anorexia Nervosa (AN-R) and 19 healthy controls. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.026DOI Listing
February 2019

Evaluation of body size and temperature on Cs uptake in marine animals.

J Environ Radioact 2019 Feb 15;202:25-31. Epub 2019 Feb 15.

School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY, 11794-5000, USA. Electronic address:

Cs bioaccumulation and retention in seven different marine animal species, including crustaceans, mollusc larvae, and fish larvae were compared under different temperature conditions (10 °C, 18 °C and 25 °C). Replicate animals were experimentally exposed to 0.5 nM Cs dissolved in filtered seawater for 3 days, and their Cs contents were periodically measured using gamma spectrometry. Read More

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http://dx.doi.org/10.1016/j.jenvrad.2019.02.005DOI Listing
February 2019

Surface-tracked scanning ion conductance microscopy: A novel imaging technique for measuring topography-correlated transmembrane ion transport through porous substrates.

Micron 2019 Feb 8;120:57-65. Epub 2019 Feb 8.

Department of Mechanical and Aerospace Engineering, The Ohio State University, 201 W 19th Ave, Columbus, OH 43210, United States. Electronic address:

Ion transport through porous substrates is ubiquitous in biological and synthetic materials, and fundamental for chemical separation, drug delivery and bio-sensing. Contemporary imaging techniques for simultaneously characterizing topography and ion transport through porous substrates are limited in range and resolution. In this paper, we demonstrate 'surface-tracked scanning ion conductance microscopy' as a technique to image topography of a porous substrate and simultaneously measure voltage-driven transmembrane ion transport. Read More

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http://dx.doi.org/10.1016/j.micron.2019.01.015DOI Listing
February 2019

Design, synthesis and biological evaluation of (E)-5-styryl-1,2,4-oxadiazoles as anti-tubercular agents.

Bioorg Chem 2019 Feb 7;86:507-512. Epub 2019 Feb 7.

Chemistry of Heterocycles & Natural Product Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India. Electronic address:

Cinnamic acid and its derivatives are known for anti-tubercular activity. The present study reports the synthesis of cinnamic acid derivatives via bioisosteric replacement of terminal carboxylic acid with "oxadiazole". A series of cinnamic acid derivatives (styryl oxadiazoles) were designed and synthesized in good yields by reaction of substituted cinnamic acids (2, 15a-15s) with amidoximes. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.01.054DOI Listing
February 2019

Activation of ATP-sensitive K-channel promotes the anticonvulsant properties of cannabinoid receptor agonist through mitochondrial ATP level reduction.

Epilepsy Behav 2019 Feb 15;93:1-6. Epub 2019 Feb 15.

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Cannabinoid receptor (CBR) agonist could act as a protective agent against seizure susceptibility in animal models of epilepsy. Studies have shown that potassium channels could play a key role in ameliorating neuronal excitability. In this study, we attempted to evaluate how CBRs and Adenosine Tri-Phosphate (ATP)-sensitive potassium channels collaborate to affect seizure susceptibility by changing the clonic seizure threshold (CST). Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.025DOI Listing
February 2019

Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids.

Stem Cell Res 2019 Feb 7;35:101383. Epub 2019 Feb 7.

Division of Molecular and Experimental Surgery, Department of Surgery, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Translational Research Center, 91054 Erlangen, Germany; Optical Imaging Centre Erlangen (OICE), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91052 Erlangen, Germany.

The aberrant regulation of the epithelial barrier integrity is involved in many diseases of the digestive tract, including inflammatory bowel diseases and colorectal cancer. Intestinal epithelial cell organoid cultures provide new perspectives for analyses of the intestinal barrier in vitro. However, established methods of barrier function analyses from two dimensional cultures have to be adjusted to the analysis of three dimensional organoid structures. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101383DOI Listing
February 2019

Morphology evolution of Janus dumbbell nanoparticles in seeded emulsion polymerization.

J Colloid Interface Sci 2019 Jan 25;543:34-42. Epub 2019 Jan 25.

Department of Materials Science and Engineering, Iowa State University of Science and Technology, Ames, IA 50011, USA; Division of Materials Science & Engineering, Ames National Laboratory, Ames, IA 50011, USA. Electronic address:

Emulsion polymerization is a versatile approach to produce different polymeric nanoparticle morphologies, which can be useful in a variety of applications. However, the detailed mechanism of the morphology formation is not entirely clear. We study the kinetics of nanoparticle morphology evolution during a seeded emulsion polymerization using both experimental and computational tools. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.01.109DOI Listing
January 2019

Ion chamber response to kilovoltage x-rays in the presence of a contrast agent.

Appl Radiat Isot 2019 Feb 2;147:14-20. Epub 2019 Feb 2.

Centro de Investigación y de Estudios Avanzados del IPN Unidad Monterrey, Vía del Conocimiento 201 Parque PIIT, Apodaca, Nuevo León, C, Mexico.P. 66600. Electronic address:

Contrast enhanced radiotherapy is a relatively new treatment modality in which a radiological contrast agent is uploaded into a tumor that is subsequently irradiated with kilovoltage x-ray beams thus maximizing absorption of radiation through the photoelectric effect. As with other treatment modalities, experimental verification of absorbed dose distributions is a necessary step as part of the quality assurance process. In this paper, we address the question of how the response to kilovoltage x-rays exhibited by an ion chamber is modified when a radiological contrast agent is incorporated into the irradiated medium. Read More

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http://dx.doi.org/10.1016/j.apradiso.2019.01.032DOI Listing
February 2019

KiSS1 in regulation of metastasis and response to antitumor drugs.

Drug Resist Updat 2019 Feb 11;42:12-21. Epub 2019 Feb 11.

Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42/via Venezian 1, 20133 Milan, Italy. Electronic address:

Metastatic dissemination of tumor cells represents a major obstacle towards cancer cure. Tumor cells with metastatic capacity are often resistant to chemotherapy. Experimental efforts revealed that the metastatic cascade is a complex process that involves multiple positive and negative regulators. Read More

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http://dx.doi.org/10.1016/j.drup.2019.02.001DOI Listing
February 2019

A meta-analysis and systematic review of Memory Specificity Training (MeST) in the treatment of emotional disorders.

Behav Res Ther 2019 Feb 2;116:36-51. Epub 2019 Feb 2.

Centre for Learning Psychology and Experimental Psychopathology, University of Leuven, Leuven, Belgium.

The tendency to recall events from one's past in a non-specific and overgeneral way has been found to predict the onset and severity of a range of emotional disorders. Memory Specificity Training (MeST) was devised a decade ago in order to target and modify this tendency so as to reduce the symptoms of emotional disorder or to reduce the risk that such disorders might emerge over time. We present a meta-analytical review of research into the effects of MeST on autobiographical memory specificity in the context of emotional disorders (k = 13). Read More

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http://dx.doi.org/10.1016/j.brat.2019.02.001DOI Listing
February 2019

Thermophilic anaerobic digestion of model organic wastes: Evaluation of biomethane production and multiple kinetic models analysis.

Bioresour Technol 2019 Feb 7;280:269-276. Epub 2019 Feb 7.

Department of Environmental Energy Engineering, Kyonggi University, Republic of Korea. Electronic address:

The main aim of this work was to test various organic wastes, i.e. from a livestock farm, a cattle slaughterhouse and agricultural waste streams, for its ability to produce methane under thermophilic anaerobic digestion (AD) conditions. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.033DOI Listing
February 2019

Novel aspects of the activation of NADPH oxidase in neutrophils of rheumatic patients on biological therapy.

Int Immunopharmacol 2019 Feb 15;69:368-372. Epub 2019 Feb 15.

5th Department of Internal Medicine, Medical Faculty of Comenius University, University Hospital, Ružinovská 6, 826 06 Bratislava, Slovak Republic.

The relationship between inflammation and formation of reactive oxygen species (ROS) is still not completely understood and excessive inflammatory reaction is attributed to increased yet also to reduced ROS formation. To compare ROS formation in severe and low inflammation, neutrophil oxidative burst was analyzed in rheumatic patients before and during therapy with TNFα- or interleukin-6 receptor-neutralizing antibodies. Intracellular and extracellular ROS productions were evaluated on the basis of luminol- and isoluminol-enhanced chemiluminescence in isolated peripheral neutrophils. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.015DOI Listing
February 2019

Systematic evaluation of a dynamic sewer process model for prediction of odor formation and mitigation in large-scale pressurized sewers in Hong Kong.

Water Res 2019 Feb 1;154:94-103. Epub 2019 Feb 1.

Guangdong Provincial Engineering Technology Research Center for Wastewater Management and Treatment, MOE Laboratory of Theoretical Chemistry of Environment, School of Chemistry & Environment, South China Normal University, Guangzhou, China. Electronic address:

To evaluate and mitigate odor formation and emission in sewers, several sewer models have been developed. Although these models can predict the immediate effects of chemical dosing on odor emission control, the long-term effects due to the variation of biofilm dynamics were generally underestimated. Therefore, in this study, we developed a dynamic model to simulate sewer processes initiated by sewer. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.033DOI Listing
February 2019

Rapid discrimination of fungal strains isolated from human skin based on microbial volatile organic profiles.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Feb 10;1110-1111:9-14. Epub 2019 Feb 10.

Department of Chemistry, State University of Maringá (UEM), Ave. Colombo 5790, Maringá, PR 87020-900, Brazil; Program of Master in Science, Technology and Food Safety, Cesumar Institute of Science, Technology and Innovation (ICETI), University Center of Maringá - (UNICESUMAR), Av. Guedner, 1610, Maringá, PR 87050-900, Brazil.

Studies of the microbiota of human skin have gained attention mainly because of its high complexity. Volatile metabolites that emerge from the microbiota play a significant role in fungus metabolism, acting on fungal development, defense, and protection against stress, communication, and pathogenicity. The present study evaluated volatile organic profiles, based on headspace-solid-phase microextraction-gas chromatography-mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.02.007DOI Listing
February 2019

Study of Cu (II), Co (II), Ni (II) and Pb (II) removal from aqueous solutions using magnetic Prussian blue nano-sorbent.

J Hazard Mater 2019 Feb 11;369:226-235. Epub 2019 Feb 11.

Center for Physical Sciences and Technology, Savanorių ave. 231, LT-02300 Vilnius, Lithuania.

In this study magnetic Prussian blue (MPB) was synthesized and applied as sorbent for the efficient removal of heavy metals (Cu (II), Co (II), Ni (II) and Pb (II)) from aqueous solution. The average diameter of nanoparticles was found to be about 15 nm. The experimental results were fitted to Langmuir, Freundlich and Dubinin-Radushkevich models with high regression coefficients. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.02.039DOI Listing
February 2019

Effects of pool size and spacing on burning rate and flame height of two square heptane pool fires.

J Hazard Mater 2019 Feb 5;369:116-124. Epub 2019 Feb 5.

Department of Building, Civil and Environmental Engineering, Concordia University, 1445 de Maisonneuve Blvd. West, Montreal, QC H3G 1M8, Canada.

The interaction of multiple pool fires might lead to higher burning rate and flame height than single pool fire, raising the possibility of fire ignition and flame spread and increasing the risks to people, buildings and environment. To quantify the burning rate and flame height of multiple pool fires from the view of physical mechanism, this paper presents an experimental study on two identical square pool fires. Heptane was used as fuel. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.01.111DOI Listing
February 2019

Chemometrics coupled with UPLC-MS/MS for simultaneous analysis of markers in the raw and processed Fructus Xanthii, and application to optimization of processing method by BBD design.

Phytomedicine 2018 Dec 15;57:191-202. Epub 2018 Dec 15.

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, PR China. Electronic address:

Background: As a widely used toxic traditional herbal medicine, the quality of the Fructus Xanthii must be well controlled to ensure the clinical therapeutic efficacy and safety.

Aims: A rapid, and sensitive using ultra-high performance liquid chromatography to triple quadrupole tandem mass spectrometry (UPLC-MS/MS) in selected reaction monitoring (SRM) mode was developed and validated for simultaneous quantitation of determination active and toxic ingredients form processed by stir-frying and raw materials of Fructus Xanthii.

Methods: Chromatographic separation of all targeted compound was performed on Waters ACQUITY UPLC HSS T3 column (50 mm × 2. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.020DOI Listing
December 2018

Toxicity profiling of 24 l-phenylalanine derived ionic liquids based on pyridinium, imidazolium and cholinium cations and varying alkyl chains using rapid screening Vibrio fischeri bioassay.

Ecotoxicol Environ Saf 2019 Feb 14;172:556-565. Epub 2019 Feb 14.

Laboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Tallinn 12618, Estonia; Estonian Academy of Sciences, Kohtu 6, Tallinn 10130, Estonia. Electronic address:

A library of 24 pyridinium-, imidazolium-, and cholinium-based ionic liquids (ILs) with varying alkyl chain from C to C was toxicologically profiled using naturally luminescent marine bacteria Vibrio fischeri. The toxicity (30-min EC) of studied ILs to Vibrio fischeri ranged from 7.82 µM (4. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2018.12.076DOI Listing
February 2019

Impacts of S-metolachlor and terbuthylazine in fatty acid and carbohydrate composition of the benthic clam Scrobicularia plana.

Ecotoxicol Environ Saf 2019 Feb 15;173:293-304. Epub 2019 Feb 15.

MARE - Marine and Environmental Sciences Centre, Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, 3004-517 Coimbra, Portugal; Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

S-metolachlor (SMOC) and terbuthylazine (TBA) are herbicides that commonly appear as active ingredients (a.i.) in the composition of plant protection products. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.034DOI Listing
February 2019

Chiral resolution and neuroprotective activities of enantiomeric dihydrobenzofuran neolignans from the fruit of Crataegus pinnatifida.

Bioorg Chem 2019 Feb 8;85:469-474. Epub 2019 Feb 8.

School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

Three pairs of enantiomeric dihydrobenzofuran neolignans (1a/1b-3a/3b) including four new compounds (1a/1b and 2a/2b) were isolated from the fruit of Crataegus pinnatifida. Their structures including the absolute configurations were elucidated by extensive spectroscopic analyses and comparison between the experimental measurements of electronic circular dichroism (ECD) and the calculated ECD spectra. Additionally, all the enantiomeric neolignans were investigated for their neuroprotective activities against HO-induced cell injury in human neuroblastoma SH-SY5Y cells. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.02.018DOI Listing
February 2019

Type I interferon responses of common carp strains with different levels of resistance to koi herpesvirus disease during infection with CyHV-3 or SVCV.

Fish Shellfish Immunol 2019 Feb 15. Epub 2019 Feb 15.

Fish Disease Research Unit, Institute for Parasitology, University of Veterinary Medicine, Hannover, Germany.

Carp from breeding strains with different genetic background present diverse levels of resistance to viral pathogens. Carp strains of Asian origin, currently being treated as Cyprinus rubrofuscus L., especially Amur wild carp (AS), were proven to be more resistant to koi herpesvirus disease (KHVD; caused by cyprinid herpesvirus 3, CyHV-3) than strains originating from Europe and belonging to Cyprinus carpio L. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.02.022DOI Listing
February 2019

I feel what I do: Relating interoceptive processes and reward-related behavior.

Neuroimage 2019 Feb 16. Epub 2019 Feb 16.

Department of Psychology, General and Experimental Psychology Unit, Ludwig-Maximilians University, D-80802, Munich, Germany.

Interoceptive signalling has been shown to contribute to action regulation and action experience. Here, we assess whether motor behaviour can be influenced by anticipated homeostatic feeling states induced through different predictable contexts. Participants performed a reward incentive paradigm in which accurate responses increased (gain) or avoided the depletion (averted loss) of a credit score. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.032DOI Listing
February 2019

WIN55,212-2 induces caspase-independent apoptosis on human glioblastoma cells by regulating HSP70, p53 and Cathepsin D.

Toxicol In Vitro 2019 Feb 15. Epub 2019 Feb 15.

Experimental Pathology Laboratory, Federal University of São João del Rei (UFSJ), 400, Sebastião Gonçalves Coelho, Chanadour, Divinópolis, MG, Brazil. Electronic address:

Despite the standard approaches to treat the highly aggressive and invasive glioblastoma (GBM), it remains incurable. In this sense, cannabinoids highlight as a promising tool, because this tumor overexpresses CB1 and/or CB2 receptors and being, therefore, can be susceptible to cannabinoids treatment. Thus, this work investigated the action of the cannabinoid agonist WIN55-212-2 on GBM cell lines and non-malignant cell lines, in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.009DOI Listing
February 2019

Refractory diet-dependent changes in neural microstructure: Implications for microstructural endophenotypes of neurologic and psychiatric disease.

Magn Reson Imaging 2019 Feb 15. Epub 2019 Feb 15.

Department of Biomedical Engineering, College of Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Neuroscience Training Program, Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA. Electronic address:

Alterations in gut microbiome populations via dietary manipulation have been shown to induce diet-dependent changes in white matter microstructure. The purpose of this study is to examine the durability of these diet-induced microstructural alterations. We implemented a crossover experimental design where post-weaned male rats were assigned to one of four experimental diets. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.006DOI Listing
February 2019

Cost-effectiveness of web-based patient-reported outcome surveillance in lung cancer patients.

J Thorac Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of radiation oncology, Jean Bernard center, Inter-regional Institute of Oncology, Le Mans, France.

Background: A multicenter randomized clinical trial in France found an overall survival benefit of web-based patient-reported outcome (PRO)-based surveillance following initial treatment for lung cancer compared with conventional surveillance. The aim of this study was to assess the cost-effectiveness of this PRO-based surveillance in lung cancer patients.

Methods: This medico-economic analysis employed data from the clinical trial, augmented by abstracted chart data and costs of consultations, imaging, transportations, information technology, and treatments. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.005DOI Listing
February 2019

An Expanded Conformation of an Antibody Fab Region by X-Ray Scattering, Molecular Dynamics and smFRET Identifies an Aggregation Mechanism.

J Mol Biol 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemical Engineering, University College London, Gordon Street, London, WC1E 7JE, UK. Electronic address:

Protein aggregation is the underlying cause of many diseases, and also limits the usefulness of many natural and engineered proteins in biotechnology. Better mechanistic understanding and characterization of aggregation-prone states, is needed to guide protein engineering, formulation, and drug-targeting strategies that prevent aggregation. While several final aggregated states - notably amyloids - have been characterized structurally, very little is known about the native structural conformers that initiate aggregation. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.02.009DOI Listing
February 2019

Smartphone use while eating increases caloric ingestion.

Physiol Behav 2019 Feb 15. Epub 2019 Feb 15.

Health Sciences Department, Universidade Federal de Lavras, Lavras (UFLA), Minas Gerais, Brazil. Electronic address:

The use of smartphones during meals may possibly influence the number of ingested calories. We evaluated the influence of smartphones' distraction during eating on caloric intake. Physical (masticatory parameters, sex and body mass index - BMI); environmental (with or without distraction) and psychological (stress levels) variables were evaluated as confounding factors. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.02.021DOI Listing
February 2019

Novel antimicrobial agents' discovery among the steroid derivatives.

Steroids 2019 Feb 15. Epub 2019 Feb 15.

Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković, University of Belgrade, Bulevar Despota Stefana, Serbia.

Fourteen steroid compounds were in silico evaluated using computer program PASS as antimicrobial agents. The experimental studies evaluation revealed that all compounds have good antibacterial activity with MIC at range of 0.003-0. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.02.012DOI Listing
February 2019
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Self-propagating, non-synaptic epileptiform activity propagates by endogenous electric fields.

Exp Neurol 2019 Feb 15. Epub 2019 Feb 15.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

It is well documented that synapses play a significant role in the transmission of information between neurons. However, in the absence of synaptic transmission, neural activity has been observed to continue to propagate. Previous studies have shown that propagation of epileptiform activity takes place in the absence of synaptic transmission and gap junctions and is outside the range of ionic diffusion and axonal conduction. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.02.005DOI Listing
February 2019

Endogenous multidien rhythm of epilepsy in rats.

Exp Neurol 2019 Feb 15. Epub 2019 Feb 15.

Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.

Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal. Here, we analyzed chronic EEG data (>30 days) in male epileptic rats and unraveled not only circadian but also, slower, multidien rhythms of interictal epileptiform activity with periodicity of about 2-3 and 5-7 days. Importantly, seizures were not uniformly distributed over time, but rather clustered at preferential phases of these underlying rhythms, delineating critical circadian times and multidien phase of heightened seizure risk. Read More

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http://dx.doi.org/10.1016/j.expneurol.2019.02.006DOI Listing
February 2019

Rsp5-dependent endocytosis and degradation of the arsenite transporter Acr3 requires its N-terminal acidic tail as an endocytic sorting signal and arrestin-related ubiquitin-ligase adaptors.

Biochim Biophys Acta Biomembr 2019 Feb 15. Epub 2019 Feb 15.

Institute of Experimental Biology, University of Wroclaw, 50-328 Wroclaw, Poland. Electronic address:

The yeast plasma membrane transporter Acr3 mediates efflux of toxic arsenite and antimonite. Here, we investigated the mechanisms of Acr3 turnover. We found that after arrival and residence at the plasma membrane, Acr3 is subjected to internalization followed by proteolysis in the vacuole. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.02.004DOI Listing
February 2019

Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence.

J Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

Institute of Virology, University of Veterinary Medicine Hannover, Foundation, Germany.

We analyzed the virulence of pandemic H1N1 2009 influenza A viruses in vivo and in vitro. Selected viruses isolated in 2009, 2010, 2014, and 2015 were assessed using an aerosol-mediated high-dose infection model for pigs as well as air-liquid interface cultures of differentiated airway epithelial cells. Using a dyspnea score, rectal temperature, lung lesions, and viral load in the lung as parameters, the strains from 2014-2015 were significantly less virulent than the strains isolated in 2009-2010. Read More

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http://dx.doi.org/10.1093/infdis/jiy719DOI Listing
February 2019

Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial.

JAMA 2019 Feb 18. Epub 2019 Feb 18.

Clinical Trials Unit, Intensive Care National Audit & Research Centre, London, United Kingdom.

Importance: A meta-analysis of outcomes during the 6 months after intensive care unit (ICU) discharge indicate a prevalence for clinically important posttraumatic stress disorder (PTSD) symptoms of 25%.

Objective: To determine whether a nurse-led preventive, complex psychological intervention, initiated in the ICU, reduces patient-reported PTSD symptom severity at 6 months.

Design, Setting, And Participants: A multicenter, parallel-group, cluster-randomized clinical trial with integrated economic and process evaluations conducted in 24 ICUs in the United Kingdom. Read More

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http://dx.doi.org/10.1001/jama.2019.0073DOI Listing
February 2019

Dynamic Fixation Versus Static Fixation for Distal Tibiofibular Syndesmosis Injuries: A Meta-Analysis.

Med Sci Monit 2019 Feb 18;25:1314-1322. Epub 2019 Feb 18.

Department of Orthopaedics, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China (mainland).

BACKGROUND Ankle sprains with distal tibiofibular syndesmosis injuries (DTSIs) require anatomic reduction and fixation to restore the normal biomechanics of the ankle joint. In the last decade, dynamic fixation (DF) for DTSIs using a suture-button device has gained popularity because of its advantages over static fixation (SF). MATERIAL AND METHODS The present meta-analysis was conducted to compare clinical outcomes between DF and SF of DTSIs. Read More

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http://dx.doi.org/10.12659/MSM.913324DOI Listing
February 2019

[Neurobiological bases of autism and cellular models for its experimental study].

Medicina (B Aires) 2019 ;79 Suppl 1:27-32

Intituto de Neurociencias UMH-CSIC. San Joan d'Alacant. Alicante. España. E-mail:

Autism Spectrum Disorders (ASD) are a functional alteration of the cerebral cortex, which presents structural neurodevelopmental anomalies that affect synaptic function and the pattern of connections within and between cortical columns. From its etiological aspect, ASD has an important genetic load, considering a polygenic disorder, derived from a combination of "de novo" genetic mutations, associated to a predisposition derived from common inherited variations. The main genetic anomalies associated with ASD involve genes that encode proteins of the synapse. Read More

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January 2019

Bio-Ferroelectric Properties of Glycine Crystals.

J Phys Chem Lett 2019 Feb 18. Epub 2019 Feb 18.

Biological ferroelectric materials have great potential in biosensing, disease di-agnosis and treatment. And the glycine crystal is the simplest bio-ferroelectrics. We have investigated the polarizations of two phases of glycine crystals, namely the β- and γ-phases. Read More

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http://dx.doi.org/10.1021/acs.jpclett.8b03837DOI Listing
February 2019

Chemical reaction-driven spreading of organic extractant on gas-water interface: Insight into controllable formation of gas bubble-supported organic extractant liquid membrane.

Langmuir 2019 Feb 18. Epub 2019 Feb 18.

Extraction and recovery of low-concentration valuable metals from various complex aqueous solutions or industrial waste waters have attract extensive interests in recent years. In our previous works, we suggested a novel technique called bubbling organic liquid membrane extraction by spreading and covering an organic extractant with extremely small volume on the surface of gas bubbles to form a layer of gas bubble-supported organic liquid membrane for selective extraction and enrichment of low-concentration targets from dilute aqueous solutions. It was found that, for successfully performing the bubbling organic liquid membrane extraction, a prerequisite is how to control the formation of stable organic liquid membrane covered on the surface of gas bubbles. Read More

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http://dx.doi.org/10.1021/acs.langmuir.8b03954DOI Listing
February 2019

Hyperbolic Meta-Antennas Enable Full Control of Scattering and Absorption of Light.

Nano Lett 2019 Feb 18. Epub 2019 Feb 18.

We introduce a novel concept of hybrid metal-dielectric meta-antenna supporting type II hyperbolic dispersion, which enables a full control of absorption and scattering of light in the visible/near-infrared spectral range. This ability lies on the different nature of the hyperbolic Bloch-like modes excited within the meta-antenna. The experimental evidence is corroborated by a comprehensive theoretical study. Read More

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http://dx.doi.org/10.1021/acs.nanolett.8b04841DOI Listing
February 2019

Wetting criteria of intrinsic contact angle to distinguish between hydrophilic and hydrophobic micro/nano-textured surfaces: Experimental and theoretical analysis with synchrotron X-ray imaging.

Langmuir 2019 Feb 18. Epub 2019 Feb 18.

In this study, existing knowledge on the wetting criterion, i.e., the intrinsic contact angle, for distinguishing between hydrophilic and hydrophobic textured surfaces is verified experimentally. Read More

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http://dx.doi.org/10.1021/acs.langmuir.8b03407DOI Listing
February 2019

Role of Structural Distortion in Stabilizing Electrosynthesized Blue-Emitting Phosphorene Quantum Dots.

J Phys Chem Lett 2019 Feb 18:973-980. Epub 2019 Feb 18.

CSIR-Central Electrochemical Research Institute , Karaikudi 630003 , Tamilnadu , India.

Luminescent phosphorene quantum dots (PQDs) have emerged as fascinating nanomaterials for potential applications in optoelectronics, catalysis, and sensing. Herein, we investigate the structural distortion of black phosphorus (BP) under an applied electric field to yield blue luminescent PQDs [average diameter 8 ± 1.5 nm ( N = 60)]. Read More

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http://dx.doi.org/10.1021/acs.jpclett.8b03600DOI Listing
February 2019

Molecular Potential Energies from Experimental Electric Field and Electrostatic Potential at Nuclei.

J Phys Chem A 2019 Feb 18. Epub 2019 Feb 18.

In this paper, the molecular electrostatic potential energy V is first estimated from the electric field generated by an experimental electron density. Once the high resolution X-ray diffraction data are fitted against the Hansen-Coppens multipole model, the electric field E is analytically computed on every point inside and around the molecule by using our own software FIELD. The potential energy is then obtained by a numerical and robust integration of E2/2. Read More

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http://dx.doi.org/10.1021/acs.jpca.8b12305DOI Listing
February 2019

Catalytic Mechanism for 2,3-Dihydroxybiphenyl Ring-Cleavage by Non-Heme Extradiol Dioxygenases Bphc: Insights from QM/MM Analysis.

J Phys Chem B 2019 Feb 18. Epub 2019 Feb 18.

An extradiol-cleaving catecholic dioxygenase, BphC, plays important roles in catabolism of biphenyl/polychlorinated biphenyls (PCBs) aromatic contaminants in the environment. To better elucidate the biodegradable pathway, a theoretical investigation of the ring-open degradation for 2,3-dihydroxybiphenyl (DHBP) was performed with the aid of quantum mechanical/molecular mechanical (QM/MM) calculations. A quintet state of the DHBP-iron-dioxygen group adducts was found to be reactive ground state with a substrate radical-FeII-superoxo (DHBP• ↑-FeII-O2• ‾↓) character. Read More

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http://dx.doi.org/10.1021/acs.jpcb.8b11008DOI Listing
February 2019
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