1,417,603 results match your criteria Journal of Experimental & Clinical Assisted Reproduction JECAR [Journal]


Thymic Epithelial Tumors: Prognostic Significance and Relationship between Histology and the New TNM Staging System.

Thorac Cardiovasc Surg 2019 Feb 22. Epub 2019 Feb 22.

Department of Morfology, Experimental Medicine and Surgery, Section of General and Thoracic Surgery, Sant'Anna Hospital, University of Ferrara, Ferrara, Italy.

Background:  This study aims to describe the relationship between the new tumor nodes metastasis (TNM) staging and World Health Organization (WHO) classification and to identify how these two variables relate to each other and whether they possess a prognostic value in predicting survival and recurrence of disease.

Methods:  Medical records of 54 patients who underwent surgery for thymic epithelial tumors between 1996 and 2015 were reviewed.The histologic type of neoplasm was classified according to the criteria of WHO and staging was evaluated using the new TNM classification system. Read More

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http://dx.doi.org/10.1055/s-0039-1678612DOI Listing
February 2019

The Neuroprotective Peptide PACAP1-38 Contributes to Horizontal Cell Development in Postnatal Rat Retina.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):770-778

Department of Experimental Zoology and Neurobiology, University of Pécs, Pécs, Hungary.

Purpose: PACAP1-38, a member of the secretin/glucagon superfamily, is expressed in the developing retina with documented neuroprotective effects. However, its function in retinal cell differentiation has yet to be elucidated. Our goals, therefore, were to identify PAC1 expressing cells morphologically, investigate the PACAP1-38 action functionally, and establish PACAP1-38 regulated events developmentally during the first postnatal week in rat retina. Read More

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http://dx.doi.org/10.1167/iovs.18-25719DOI Listing
February 2019

From qualitative to quantitative description of the anomalous thermoelastic behavior of V, Nb, Ta, Pd and Pt.

J Phys Condens Matter 2019 Feb 22. Epub 2019 Feb 22.

Materials Chemistry, Rheinisch - Westfalische Technische Hochschule Aachen, Aachen, GERMANY.

To study the anomalous thermoelastic behavior of bcc V, Nb, Ta as well as fcc Pd and Pt a density functional theory based model is used, which allows for the calculation of the elastic constant c' and c<sub>44</sub> as a function of temperature. Available experimental c<sub>44</sub> trends are correctly reproduced indicating that the electronic structure mechanisms enabling anomalous behavior are captured by the model. A density functional theory based correlative investigation between V, Nb, Ta, Pd and Pt with anomalous thermoelastic properties and Mo and Cu with ordinary behavior reveals a high density of states at the Fermi level to be a necessary but not sufficient condition for an anomalous thermoelastic behavior. Read More

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http://dx.doi.org/10.1088/1361-648X/ab099bDOI Listing
February 2019

Lateral heterostructures and one-dimensional interfaces in 2D transition metal dichalcogenides.

J Phys Condens Matter 2019 Feb 22. Epub 2019 Feb 22.

Department of Physics and Astronomy, Ohio University, 251 Clippinger Laboratories, Athens, Ohio, 45701, UNITED STATES.

The growth and exfoliation of two-dimensional (2D) materials have led to the creation of edges and novel interfacial states at the juncture between crystals with different composition or phases. These hybrid heterostructures (HSs) can be built as vertical van der Waals \textit{stacks}, resulting in a 2D interface, or as \textit{stitched} adjacent monolayer crystals, resulting in one-dimensional (1D) interfaces. Although most attention has been focused on vertical HSs, increasing theoretical and experimental interest in 1D interfaces is evident. Read More

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http://dx.doi.org/10.1088/1361-648X/ab0970DOI Listing
February 2019

Leukoencephalopathy, intracranial calcifications, cysts and SNORD118 mutation (Labrune Syndrome) with obstructive hydrocephalus.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Atkinson Morley Neurosurgery Centre, St George's University Hospital NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1016/j.wneu.2019.02.008DOI Listing
February 2019

Dysphagia prevention in anterior cervical discectomy surgery.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Neurosurgical Clinic, Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, School of Medicine, Palermo, Italy.

Background: Dysphagia is a common complication after anterior cervical discectomy surgery (ACDS). Recent studies have shown that reducing the endotracheal tube cuff pressure (ETCP), local irrigation with methylprednisolone, and minimizing the pharynx/esophagus retraction can decrease the incidence of post-operative dysphagia following ACDS. This is the first study assessing the efficacy of all these three measures simultaneously. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.273DOI Listing
February 2019

Exploring the influence of the surface proteins on probiotic effects performed by Lactobacillus pentosus HC-2 using transcriptome analysis in Litopenaeus vannamei midgut.

Fish Shellfish Immunol 2019 Feb 19. Epub 2019 Feb 19.

CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao, 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China; CAS Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, 266400, China. Electronic address:

In order to understand the mediation function of surface proteins in probiotic effects executed by Lactobacillus pentosus HC-2 in midgut of Litopenaeus vannamei, the immune and digestion related enzymes and the transcriptome expression were analyzed after shrimp fed with normal HC-2 or with stripped surface proteins HC-2 by lithium chloride (LiCl) treatment. The results showed that the shrimp fed with normal HC-2 produced much higher immune and digestion related enzymes than the control group or LiCl-treated HC-2 group to defense the Vibrio parahaemolyticus E1 infection. We obtained total over 275,099 unigenes from L. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.02.027DOI Listing
February 2019

Autologous Transplantation for Male Germ Cell Tumors: Improved Outcomes over 3 decades.

Biol Blood Marrow Transplant 2019 Feb 19. Epub 2019 Feb 19.

Medical College of Wisconsin, Milwaukee, WI.

Purpose: The curative potential of autologous hematopoietic cell transplantation (autoHCT) for male germ cell tumors (GCT) is well established. Optimal timing and number (single, ST vs. tandem, TT vs. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.015DOI Listing
February 2019

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy. Electronic address:

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed primarily in nociceptors, mediates the action of proalgesic and inflammatory agents. Ibuprofen metabolism yields the reactive compound, ibuprofen-acyl glucuronide, which, like other TRPA1 ligands, covalently interacts with macromolecules. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.019DOI Listing
February 2019

Cloning of nitrite reductase gene from Haematococcus pluvialis and transcription and enzymatic activity analysis at different nitrate and phosphorus concentration.

Gene 2019 Feb 19. Epub 2019 Feb 19.

College of Marine Life Sciences, Ocean University of China/Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Qingdao 266003, Shandong, China.

Haematococcus pluvialis is an economic microalga to produce astaxathin. To study the nitrogen metabolic process of H. pluvialis, the transcription level and enzyme content of nitrite reductase at different nitrate and phosphorus concentrations were studied. Read More

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http://dx.doi.org/10.1016/j.gene.2019.01.042DOI Listing
February 2019

Silencing of ionotropic receptor 25a decreases chemosensory activity in the salmon louse Lepeophtheirus salmonis during the infective stage.

Gene 2019 Feb 19. Epub 2019 Feb 19.

Institute of Marine Research, Austevoll Research Station, Saugeneset 16, 5392 Storebø, Norway. Electronic address:

Chemoreception is critical for marine ectoparasites - such as salmon lice (Lepeophtheirus salmonis) - to identify and locate salmonid hosts. The molecular receptors that parasites employ to detect host-specific chemical stimuli from hosts (kairomones) have not been well characterised. In the present study, transcription of the sea louse Ionotropic receptor 25a (IR25a) was blocked to evaluate whether it functions as a chemical-perception related gene for a specific chemical cue from the Atlantic salmon host. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.012DOI Listing
February 2019

Dynamic oligomerization of hRAGE's transmembrane and cytoplasmic domains within SDS micelles.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Department of Biological Sciences (Biochemistry Program), Faculty of Science, Kuwait University, P.O. Box 5969, 13060, Kuwait.

The human Receptor for Advanced Glycation End Products (hRAGE) is a pattern recognition receptor implicated in inflammation and adhesion. It is involved in both innate and adaptive immunity. Its aberrant signaling is tied to the pathogenesis of diabetic complications, neurodegenerative disorders, and chronic inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.108DOI Listing
February 2019

Hydrothermal encapsulation of lanthanum oxide derived Aegle marmelos admixed chitosan bead system for nitrate and phosphate retention.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, Anna University, University College of Engineering - Dindigul, Reddiyarchatram, Dindigul 624 622, Tamilnadu, India. Electronic address:

The potential of hydrothermal technology was utilized for the preparation of promising adsorbents in order to overcome the troubles of methemoglobinemia (blue baby syndrome) and eutrophication which is caused by excess nitrate (NO) and phosphate (PO) ions in water. Hence, in the present investigation, the chitosan encapsulated lanthanum oxide (LaO) admixed Aegle marmelos(AM) (LaOAM@CS) composite beads was prepared by both in situ precipitation (In situ) and hydrothermal (Hydro) methods for NO and PO adsorption. The hydro supported LaOAM@CS composite beads hold an enhanced nitrate and phosphate sorption capacity (SC) of 27. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.106DOI Listing
February 2019

Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca homeostasis.

Parasitol Int 2019 Feb 19. Epub 2019 Feb 19.

Instituto de Estudios Avanzados (IDEA), Caracas, Venezuela; Instituto de Biología Experimental, Facultad de Ciencias, Universidad Central de Venezuela, Caracas, Venezuela. Electronic address:

Leishmaniasis is a parasitic disease representing an important problem of public health. Visceral leishmaniasis, resulting from infection with Leishmania donovani, causes considerable mortality and morbidity in the poorest region of the word. At present there is no current effective treatment, since the approved, drugs are expensive and are not free of undesirable side effects. Read More

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http://dx.doi.org/10.1016/j.parint.2019.02.006DOI Listing
February 2019

Contributions of non-primary cortical sources to auditory temporal processing.

Neuroimage 2019 Feb 19. Epub 2019 Feb 19.

Research Group Experimental ORL, Department of Neurosciences, KU Leuven - University of Leuven, Belgium.

Temporal processing is essential for speech perception and directional hearing. However, the number and locations of cortical sources involved in auditory temporal processing are still a matter of debate. Using source reconstruction of human EEG responses, we show that, in addition to primary sources in the auditory cortices, sources outside the auditory cortex, designated as non-primary sources, are involved in auditory temporal processing. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.037DOI Listing
February 2019

Dihydrotestosterone activates AP-1 in LNCaP prostate cancer cells.

Int J Biochem Cell Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Biochemistry and Molecular Biology, D-66421 Homburg, Germany.

A cross-talk between androgen/androgen receptor signaling and the AP-1 transcription factor has been proposed. In this study, we asked whether activation of AP-1 modifies androgen-responsive gene transcription, and whether androgens effect AP-1-regulated gene transcription. We show that activation of AP-1 via expression of a constitutively active mutant of mitogen-activated/extracellular signal responsive kinase kinase (MEK) kinase-1 did not increase the activity of the androgen-responsive probasin promoter. Read More

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http://dx.doi.org/10.1016/j.biocel.2019.02.005DOI Listing
February 2019

Optimisation of an in-line Raman spectroscopic method for continuous API quantification during twin-screw wet granulation and its application for process characterization.

Eur J Pharm Biopharm 2019 Feb 19. Epub 2019 Feb 19.

Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Universitaetstrasse1, 40225 Duesseldorf. Electronic address:

In a previous publication, the development of an in-line Raman spectroscopic method for continuous API quantification during twin-screw wet granulation was presented. An in-line method was developed successfully and the developed method showed an acceptable prediction error. A disadvantage of the developed method was that a measurement was only possible in the dark since light influenced the Raman spectra and made a data interpretation impossible. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.015DOI Listing
February 2019

Triclosan-loaded chitosan as antibacterial agent for adhesive resin.

J Dent 2019 Feb 19. Epub 2019 Feb 19.

Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil. Electronic address:

Objectives: The aim of this study was to formulate and to evaluate the immediate and long-term physical, chemical and antibacterial properties of an experimental adhesive resin with chitosan or triclosan-loaded chitosan.

Materials And Methods: Chitosan, triclosan and triclosan-loaded chitosan were evaluated for scanning electron microscopy (SEM) and micro-Raman spectroscopy. An experimental adhesive resin was formulated with methacrylate monomers and photoinitiators. Read More

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http://dx.doi.org/10.1016/j.jdent.2019.02.002DOI Listing
February 2019

Deciphering the virulence of Mycobacterium avium subsp. paratuberculosis isolates in animal macrophages using mathematical models.

J Theor Biol 2019 Feb 19. Epub 2019 Feb 19.

Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Derio, 48160 Bizkaia, Spain.

Understanding why pathogenic Mycobacterium avium subsp. paratuberculosis (Map) isolates cause disparate disease outcomes with differing magnitudes of severity is important in designing and implementing new control strategies. We applied a suite of mathematical models: i) general linear, ii) and neurofuzzy logic, to explain how the host of origin of several Map isolates, Map genotype, host, macrophage-based in vitro model and time post-infection contributed to the infection. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.01.040DOI Listing
February 2019

ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients.

Hum Immunol 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland. Electronic address:

The objective of this case-control study was to evaluate the role of four single-nucleotide polymorphisms in the ERAP1 (rs2287987, rs30187, rs27044) and ERAP2 (rs2248374) genes and their haplotypes in predicting the risk for ankylosing spondylitis (AS) on a well-defined Polish population. Our study confirmed the strong association between the HLA-B*27 allele and the disease. For all tested ERAP1 SNPs we found significant differences in the minor allele and genotype distribution between patients and controls. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.004DOI Listing
February 2019

A systematic review of practices to promote vegetable acceptance in the first three years of life.

Appetite 2019 Feb 19. Epub 2019 Feb 19.

Division of Human Nutrition and Health, Wageningen University, PO Box 17, 6700 AA, Wageningen, the Netherlands. Electronic address:

Background: Although most children do not meet vegetable intake recommendations no clear universal guidelines exist on the best method of introducing and promoting vegetables in infants.

Objective: To identify strategies to promote vegetable acceptance in children from the start of complementary feeding until 3 years of age.

Design: A comprehensive search strategy was performed using the databases Scopus and Pubmed. Read More

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http://dx.doi.org/10.1016/j.appet.2019.02.003DOI Listing
February 2019

β-Catenin and yes-associated protein 1 cooperate in hepatoblastoma pathogenesis.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Gynecology, Shiyan Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan, China. Electronic address:

Hepatoblastoma (HB), the most common pediatric primary liver neoplasm, show nuclear localization of β-catenin and yes-associated protein1 (YAP1) in almost 80% of the cases. Co-expression of constitutively active S127A-YAP1 and ΔN90 deletion-mutant-β-catenin (YAP1-ΔN90-β-catenin) causes HB in mice. Since heterogeneity in downstream signaling is being identified owing to mutational differences even in β-catenin gene alone, we investigated if co-expression of point-mutants of β-catenin (S33Y or S45Y) with S127A-YAP1 led to similar tumors as YAP1-ΔN90-β-catenin. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.02.002DOI Listing
February 2019

Intrinsic Bone Defects in Cystinotic Mice.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Bone Physiopathology Group, Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital, Rome, Italy.

Cystinosis is a rare lysosomal storage disorder caused by loss of function mutations of the CTNS gene, encoding cystinosin, a symporter that mediates cystine efflux from lysosomes. About 95% of patients with cystinosis display renal Fanconi syndrome, short stature, osteopenia, and rickets . In this study, we investigated whether the absence of cystinosin primarily affects bone remodeling activity, apart from the influences of the Fanconi syndrome on bone mineral metabolism. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.015DOI Listing
February 2019

TEA domain transcription factor 4 (TEAD4) is the major mediator of Yap oncogenic activity in mouse and human hepatoblastoma.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA. Electronic address:

Hepatoblastoma (HB) is the most common type of pediatric liver cancer. Activation of Yes-associated protein (YAP) has been implicated in HB molecular pathogenesis. The transcriptional co-activator Yap regulates downstream gene expression through interaction with the TEA domain (TEAD) proteins. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.016DOI Listing
February 2019

On the spatiotemporal regulation of cell tensional state.

Exp Cell Res 2019 Feb 19. Epub 2019 Feb 19.

Univ. Grenoble Alpes, CNRS, LIPhy, F-38000 Grenoble, France.

Since the emergence of mechanobiology, mechanical signals have been shown to influence almost every process in biology. Cells transduce mechanical signals into biochemical signaling pathways, adjust their behavior and/or phenotype before transmitting these signals to neighboring cells. Mechanical signals thus appear as information, which can be "written" by cells in the surrounding extracellular matrix, "transmitted" through it and "read" by other cells. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.02.018DOI Listing
February 2019

Experimental Investigation on Vertically-Oriented Graphene Grown in a Plasma Enhanced Chemical Vapor Deposition Process.

ACS Appl Mater Interfaces 2019 Feb 22. Epub 2019 Feb 22.

Vertically-oriented graphene with 3D architectures has been proved to exhibit unique properties and their particular morphology has been realized by researchers to be crucial for their performances in practical applications. In this study, we investigated the morphology evolution of VG films synthesized by the plasma enhanced chemical vapor deposition (PECVD) process, including porous graphene film, graphene wall, and graphene forest. This study reveals that the morphology of VG is controlled by a combination of the deposition and etching effects and tailored by the growth conditions, such as plasma source power, growth time and temperature. Read More

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http://dx.doi.org/10.1021/acsami.9b00896DOI Listing
February 2019

A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2.

PLoS One 2019 22;14(2):e0212859. Epub 2019 Feb 22.

Department of Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.

Objectives: Elevated matrix metalloproteinase-2 (MMP-2) tissue levels have been associated with ascending thoracic aortic aneurysm (aTAA). As MMP-2 activation is controlled by interactions among matrix metalloproteinase-14 (MMP-14), a tissue inhibitor of metalloproteinases-2 (TIMP-2) and Pro-MMP-2 in cell culture, this activation process might also play a role in aTAA.

Methods: Via gelatin zymography we analyzed tissue levels of MMP-2 isoforms (Pro-MMP-2, active MMP-2, total MMP-2) and via enzyme-linked immunosorbent assay (ELISA,) MMP-14,TIMP-2 and total MMP-2 tissue levels in N = 42 patients with aTAA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212859PLOS
February 2019

Effects of person-centered care at the organisational-level for people with dementia. A systematic review.

PLoS One 2019 22;14(2):e0212686. Epub 2019 Feb 22.

School of Nursing, Faculty of Medicine, The University of Notre Dame Sydney, New South Wales, Australia.

The aim of the systematic review was to determine the effectiveness of organizational-level person-centered care for people living with dementia in relation to their quality of life, mood, neuropsychiatric symptoms and function. ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialised Register databases, were searched up to June 2018 using the terms dementia OR cognitive impairment OR Alzheimer AND non-pharmacological AND personhood OR person-centered care. Reviewed studies included randomized controlled trials (RCTs), cluster-randomized trials (CRTs) and quasi-experimental studies that compared outcomes of person-centered care and usual (non-person-centered) care, for people with a diagnosis of dementia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212686PLOS
February 2019

Reconsidering the roots, structure, and implications of gambling motives: An integrative approach.

PLoS One 2019 22;14(2):e0212695. Epub 2019 Feb 22.

Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain.

Rationale And Method: Accurately identifying motives to gamble is crucial in the functional analysis of gambling behavior. In this study, a data-driven approach was followed to clarify the factor structure underlying a pool of motives for gambling, selected from the Gambling Motives Questionnaire-Financial (GMQ-F), and the Reasons for Gambling Questionnaire (RGQ), in a sample of regular problem and non-problem gamblers. Additionally, the role of gambling motives in the relationship between root behavioral activation/inhibition systems (BIS/BAS) and gambling severity, frequency, and preferences was explored using structural equation modelling (SEM). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212695PLOS
February 2019

A simulation environment for studying transcutaneous electrotactile stimulation.

PLoS One 2019 22;14(2):e0212479. Epub 2019 Feb 22.

Faculty of Science and Technology, Free University of Bozen - Bolzano, Bruneck - Brunico, Italy.

Transcutaneous electrical nerve stimulation (TENS) allows the artificial excitation of nerve fibres by applying electric-current pulses through electrodes on the skin's surface. This work involves the development of a simulation environment that can be used for studying transcutaneous electrotactile stimulation and its dependence on electrode layout and excitation patterns. Using an eight-electrode array implementation, it is shown how nerves located at different depths and with different orientations respond to specific injected currents, allowing the replication of already reported experimental findings and the creation of new hypotheses about the tactile sensations associated with certain stimulation patterns. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212479PLOS
February 2019

Automatic segmentation of the foveal avascular zone in ophthalmological OCT-A images.

PLoS One 2019 22;14(2):e0212364. Epub 2019 Feb 22.

Department of Computer Science, University of A Coruña, A Coruña, Spain.

Angiography by Optical Coherence Tomography (OCT-A) is a non-invasive retinal imaging modality of recent appearance that allows the visualization of the vascular structure at predefined depths based on the detection of the blood movement through the retinal vasculature. In this way, OCT-A images constitute a suitable scenario to analyze the retinal vascular properties of regions of interest as is the case of the macular area, measuring the characteristics of the foveal vascular and avascular zones. Extracted parameters of this region can be used as prognostic factors that determine if the patient suffers from certain pathologies (such as diabetic retinopathy or retinal vein occlusion, among others), indicating the associated pathological degree. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212364PLOS
February 2019

Similar changes in executive function after moderate resistance training and loadless movement.

PLoS One 2019 22;14(2):e0212122. Epub 2019 Feb 22.

Department of Kinesiology, University of Waterloo, Waterloo, Canada.

Growing evidence suggests that physical exercise may improve cognitive function in the short- and long-term. Aerobic exercise has been studied most extensively. Preliminary work suggests that resistance training also improves cognitive function, particularly executive function. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212122PLOS
February 2019

Langevin equations from experimental data: The case of rotational diffusion in granular media.

PLoS One 2019 22;14(2):e0212135. Epub 2019 Feb 22.

Dipartimento di Fisica, Sapienza Università di Roma, p.le A. Moro 2, 00185 Roma, Italy.

A model has two main aims: predicting the behavior of a physical system and understanding its nature, that is how it works, at some desired level of abstraction. A promising recent approach to model building consists in deriving a Langevin-type stochastic equation from a time series of empirical data. Even if the protocol is based upon the introduction of drift and diffusion terms in stochastic differential equations, its implementation involves subtle conceptual problems and, most importantly, requires some prior theoretical knowledge about the system. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212135PLOS
February 2019

Flat plate solar collector performance using alumina nanofluids: Experimental characterization and efficiency tests.

PLoS One 2019 22;14(2):e0212260. Epub 2019 Feb 22.

Departamento de Ingeniería Mecánica y Construcción, Universitat Jaume I, Castellón de la Plana, Spain.

Solar energy has become an important renewable energy source for reducing the use of fossil fuels and to mitigate global warming, for which solar collectors constitute a technology that is to be promoted. The use of nanofluids can increase the efficiency of solar into thermal energy conversion in solar collectors. Experimental values for the specific heat, thermal conductivity and viscosity of alumina/water nanofluids are needed to evaluate the influence of the solid content (from 0. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212260PLOS
February 2019

CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review.

PLoS One 2019 22;14(2):e0212198. Epub 2019 Feb 22.

Friedrich Baur Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.

Introduction: The system of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (cas) is a new technology that allows easier manipulation of the genome. Its potential to edit genes opened a new door in treatment development for incurable neurological monogenic diseases (NMGDs). The aim of this systematic review was to summarise the findings on the current development of CRISPR-cas for therapeutic purposes in the most frequent NMGDs and provide critical assessment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212198PLOS
February 2019

Galactose-deficient IgA1 and the corresponding IgG autoantibodies predict IgA nephropathy progression.

PLoS One 2019 22;14(2):e0212254. Epub 2019 Feb 22.

General Teaching Hospital, 1st Faculty of Medicine, Charles University, Department of Nephrology, Prague, Czech Republic.

Background: IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has serious outcomes with end-stage renal disease developing in 30-50% of patients. The diagnosis requires renal biopsy. Due to its inherent risks, non-invasive approaches are needed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212254PLOS
February 2019
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Italian norms and naming latencies for 357 high quality color images.

PLoS One 2019 22;14(2):e0209524. Epub 2019 Feb 22.

Department of Life Sciences, Università di Trieste, Trieste, Italy.

In the domain of cognitive studies on the lexico-semantic representational system, one of the most important means of ensuring effective experimental designs is using ecological stimulus sets accompanied by normative data on the most relevant variables affecting the processing of their items. In the context of image sets, color photographs are particularly suited to this purpose as they reduce the difficulty of visual decoding processes that may emerge with traditional image sets of line drawings. This is especially so in clinical populations. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209524PLOS
February 2019

Uncovering and resolving challenges of quantitative modeling in a simplified community of interacting cells.

PLoS Biol 2019 Feb 22;17(2):e3000135. Epub 2019 Feb 22.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

Quantitative modeling is useful for predicting behaviors of a system and for rationally constructing or modifying the system. The predictive power of a model relies on accurate quantification of model parameters. Here, we illustrate challenges in parameter quantification and offer means to overcome these challenges, using a case example in which we quantitatively predict the growth rate of a cooperative community. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000135DOI Listing
February 2019

Edge-Semantic Learning Strategy for Layout Estimation in Indoor Environment.

IEEE Trans Cybern 2019 Feb 21. Epub 2019 Feb 21.

Visual cognition of the indoor environment can benefit from the spatial layout estimation, which is to represent an indoor scene with a 2-D box on a monocular image. In this paper, we propose to fully exploit the edge and semantic information of a room image for layout estimation. More specifically, we present an encoder-decoder network with shared encoder and two separate decoders, which are composed of multiple deconvolution (transposed convolution) layers, to jointly learn the edge maps and semantic labels of a room image. Read More

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http://dx.doi.org/10.1109/TCYB.2019.2895837DOI Listing
February 2019

A Statistical Shape Constrained Reconstruction Framework for Electrical Impedance Tomography.

IEEE Trans Med Imaging 2019 Feb 19. Epub 2019 Feb 19.

A statistical shape constrained reconstruction (SSCR) framework is presented to incorporate the statistical prior information of human lung shapes for lung electrical impedance tomography (EIT). The prior information is extracted from 8000 chest computed tomography scans across 800 patients. The reconstruction framework is implemented with two approaches- a one-step SSCR and an iterative SSCR in lung imaging. Read More

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http://dx.doi.org/10.1109/TMI.2019.2900031DOI Listing
February 2019

Highlighting directional reflectance properties of retinal substructures from D-OCT images.

IEEE Trans Biomed Eng 2019 Feb 19. Epub 2019 Feb 19.

Optical Coherence Tomography (OCT), which is routinely used in ophthalmology, enables transverse optical imaging of the retina and hence the identification of the different neuronal layers. Directional OCT (D-OCT) extends this technology by acquiring sets of images at different incidence angles of the light beam. In this way, reflectance properties of photoreceptor substructures are highlighted, enabling physicians to study their orientation, which is potentially an interesting biomarker for retinal diseases. Read More

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http://dx.doi.org/10.1109/TBME.2019.2900425DOI Listing
February 2019

Enhancement of bone consolidation using high-frequency pulsed electromagnetic fields (HF-PEMFs): An experimental study on rats.

Bosn J Basic Med Sci 2019 Feb 20. Epub 2019 Feb 20.

"Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

In vitro studies showed that high-frequency pulsed electromagnetic fields (HF-PEMFs) increase the activity/expression of early and late osteogenic markers and enhance bone mineralization. The main aim of this study was to investigate the in vivo effects of HF-PEMFs on fracture healing using a rat model. A femur fracture was established by surgery in 20 male Wistar rats. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3854DOI Listing
February 2019

Rapid Divergence of Predator Functional Traits Affects Prey Composition in Aquatic Communities.

Am Nat 2019 Mar 23;193(3):331-345. Epub 2019 Jan 23.

Identifying traits that underlie variation in individual performance of consumers (i.e., trait utility) can help reveal the ecological causes of population divergence and the subsequent consequences for species interactions and community structure. Read More

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http://dx.doi.org/10.1086/701784DOI Listing

RESEARCH IN NUTRITIONAL SUPPLEMENTS AND NUTRACEUTICALS FOR HEALTH, PHYSICAL ACTIVITY AND PERFORMANCE: MOVING FORWARD.

Appl Physiol Nutr Metab 2019 Feb 22. Epub 2019 Feb 22.

Canadian Sport Institute Pacific , Victoria, British Columbia, Canada ;

This Horizons is part of a series which identifies key, forward-thinking research questions and challenges that need to be addressed. Specifically, this Horizons paper discusses research in nutritional supplements and nutraceuticals for health, physical activity and performance, and is the product of a discussion by an expert panel that took place in January 2018 prior to the Canadian Nutrition Society Thematic Conference "Advances in Sport Nutrition from Daily Living to High Performance Sport". The objective of this Horizons was to identify core considerations for future studies for this research area, and how scientists can be leaders in the field to ensure the best quality science is available for decision makers. Read More

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http://dx.doi.org/10.1139/apnm-2018-0781DOI Listing
February 2019

Rational Design of Proton-Electron-Transfer System Based on Nickel Dithiolene Complexes with Pyrazine Skeletons.

Inorg Chem 2019 Feb 22. Epub 2019 Feb 22.

Division of Chemistry, Graduate School of Science , Kyoto University , Kitashirakawa-Oiwakecho , Sakyo-ku , Kyoto 606-8502 , Japan.

To understand the effect of chemical modification on the stability and proton-electron coupling in neutral radical molecules with a proton-electron-transfer (PET) state, we investigate a nickel dithiolene complex with cyano-substituted pyrazine skeletons using experimental and theoretical methods. A Pourbaix diagram constructed from absorption spectroscopic and cyclic voltammetric measurements strongly suggests that the PET state of the complex is significantly more stable compared with that of the nonsubstituted complex. Theoretical calculations predicted that the introduction of electron-withdrawing groups leads to stabilization of the PET state mainly because of a greater delocalized electron distribution in the molecule. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03501DOI Listing
February 2019

On the Solute-Induced Structure-Making/Breaking Effect Rigorous Links Between Microscopic Behavior, Solvation Properties, and Solution Non-Ideality.

Authors:
Ariel A Chialvo

J Phys Chem B 2019 Feb 22. Epub 2019 Feb 22.

We studied the solute-induced perturbation of the solvent environment around a solute species from a microscopic viewpoint, and propose a novel approach to the understanding of the structure-making/breaking process, regardless of the type and nature of the solute-solvent interactions. Based on the Kirkwood-Buff fluctuation formalism we present a rigorous statistical mechanics description of the evolution of the solvent structure around the solute, analyze its response to small perturbations of the (TP) state conditions and composition of the system, and make direct connections between a few equivalent micro- and macroscopic manifestations as probes for, and targets of, experimental measurements. We illustrate the analysis with theoretical results from integral equation calculations of model fluids, and experimental evidence from available data for a variety of aqueous electrolyte and non-electrolyte real fluid solutions. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b00364DOI Listing
February 2019

Chemical Dynamics Simulation of Energy Transfer: Propylbenzene Cation and N Collisions.

J Phys Chem A 2019 Feb 22. Epub 2019 Feb 22.

Collisional energy transfer of highly vibrationally excited propylbenzene cation in a N bath has been studied with chemical dynamics simulations. In this work, an intermolecular potential of propylbenzene cation interacting with N was developed from SCS-MP2/6-311++G** ab initio calculations. Using a particle swarm optimization(PSO) algorithm, the ab initio results were simultaneously fit to a sum of three two-body potential, consisting of C-N, C-N and H-N, where C is carbon on benzene ring and C is carbon on the propyl side chain. Read More

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http://dx.doi.org/10.1021/acs.jpca.9b00111DOI Listing
February 2019

Probing Through-Space Polar-π Interactions in 2,6-Diarylphenols.

J Org Chem 2019 Feb 22. Epub 2019 Feb 22.

Although it is well established that the acidity of phenol can be fine-tuned with substituents on its aromatic ring via through-bond effects, the role of through-space effects on the acidity of phenols is presently poorly understood. Here, we present integrated experimental and computational studies on substituted 2,6-diarylphenols that demonstrate the essential contribution from through-space OH-π interactions and O-π interactions in the observed trends in proton affinities and acidities of 2,6-diarylphenols. Read More

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http://dx.doi.org/10.1021/acs.joc.8b03147DOI Listing
February 2019

Unequivocal Experimental Evidence of the Relationship between Emission Energies and Aurophilic Interactions.

Inorg Chem 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry , University of Sheffield , Sheffield S3 7HF , U.K.

In this paper, we describe experimental evidence of a change in the emission energy as a function of the Au-Au distance. We have employed a luminescent complex exhibiting an aurophilic interaction, which is weak enough to allow its length to be modified by external pressure but rigid enough to confer structural stability on the complex. By determining the crystal structures and emission characteristics over a range of pressures, we have identified an exponential relationship between the energy of the emitted light and the metal-metal distances under pressure. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03621DOI Listing
February 2019

Natural Product Neopeltolide as A Cytochrome bc1 Complex Inhibitor: Mechanism of Action and Structural Modification.

J Agric Food Chem 2019 Feb 22. Epub 2019 Feb 22.

The marine natural product neopeltolide was isolated from a deep-water sponge specimen of the family Neopeltidae. Neopeltolide has been proven to be a new type of inhibitor of the cytochrome bc1 complex in the mitochondrial respiration chain. However, its detailed inhibition mechanism has remained unknown. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06195DOI Listing
February 2019
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