11,247 results match your criteria Journal of Ethnopharmacology [Journal]


Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating.

J Ethnopharmacol 2019 Feb 15. Epub 2019 Feb 15.

Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Germany; Center of Behavioral Brain Sciences, Otto-von-Guericke University Magdeburg, Germany. Electronic address:

Ethnopharmacological Relevance: The plant arctic root (Rhodiola rosea, L.) is growing in northern regions of Europe, Asia and North America. Extracts of R. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.031DOI Listing
February 2019

Exploring on the bioactive markers of Codonopsis Radix by correlation analysis between chemical constituents and pharmacological effects.

J Ethnopharmacol 2019 Feb 15. Epub 2019 Feb 15.

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, People's Republic of China. Electronic address:

Ethnopharmacological Relevance: Codonopsis Radix is a commonly used traditional Chinese medicine, and has the effect of strengthening spleen and tonifying lung, nourishing blood and engendering liquid. In addition, it is also used as important food materials.

Aim Of The Study: The aim of the study was to explain the underlying correlations between chemical constituents and pharmacological effects and explore the bioactive markers of Codonopsis Radix. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.032DOI Listing
February 2019

Do recent research studies validate the medicinal plants used in British Columbia, Canada for immune-mediated and other problems in pets?

Authors:
Cheryl Lans

J Ethnopharmacol 2019 Feb 14. Epub 2019 Feb 14.

Institute for Ethnobotany and Zoopharmacognosy (IEZ) Rijksstraatweg 158A | 6573 DG | Beek | the Netherlands. Electronic address:

Ethnopharmacological Relevance: There are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain. Pet owners may have to plan for a lifetime of plant-based treatment for the conditions that lead to chronic pain in pets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.030DOI Listing
February 2019

Inhibitory ASIC2-mediated calcineurin/NFAT against colorectal cancer by triterpenoids extracted from Rhus chinensis Mill.

J Ethnopharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pharmaceutics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China. Electronic address:

Ethnopharmacological Relevance: Studies have shown that the etiology and pathogenesis of colorectal cancer are closely related to the tumor microenvironment, and the cancer tissue is still in the state of "energy deficit" and has to promote energy generation through high glycolysis. Rhus chinensis Mill is a Chinese herbal medicine used to treat various types of solid tumors in China. Colorectal cancer (CRC) is a heterogeneous disease group caused by abnormal changes in glucose metabolism resulted in lactic acid production, which remodels acidosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.029DOI Listing
February 2019

Tenacigenin B ester derivatives from Marsdenia tenacissima actively inhibited CYP3A4 and enhanced in vivo antitumor activity of paclitaxel.

J Ethnopharmacol 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Chinese Herbal Drug Discovery, Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, P.R. China. Electronic address:

Ethnopharmacological Relevance: Marsdenia tenacissima (Roxb.) Wight et Arn is a vine distributed in southwest area of China and used in folk medicine for treatment of tumors. Recent decades of studies on this plant reveal its synergistic effects with certain anticancer drugs in cancer therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.028DOI Listing
February 2019

Intravaginal treatment with Marantodes Pumilum (Kacip Fatimah) ameliorates vaginal atrophy in rats with post-menopausal condition.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Ethnopharmacological Relevance: Marantodes pumilum (MP) (Kacip Fatimah) is used to maintain the well-being of post-menopausal women. However, its role in ameliorating post menopause-related vaginal atrophy (VA) is unknown.

Aims: To investigate the ability of intravaginal MP gel treatment to ameliorate VA in sex-steroid deficient condition, mimicking post-menopause. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.027DOI Listing
February 2019

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Ethnopharmacological Relevance: Ribes alpestre Decne has been commonly used in the treatment of joint complaints.

Aim Of Study: The present study was undertaken to evaluate the antiarthritic potential of ethanolic extract and fractions of Ribes alpestre and to explore its probable mechanism of action.

Material And Methods: Complete Freunds adjuvant induced arthritis in Sprague Dawley rats was used to assess antiarthritic activity of aqueous ethanol extract, butanol and aqueous fractions at 200mg/kg oral dose for 28 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.025DOI Listing
February 2019
1 Read
2.998 Impact Factor

Acute and sub-acute toxicity of the aqueous extract from the stem bark of Tetrapleura tetrapteura Taub. (Fabaceae) in mice and rats.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

H.E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research (P.C.M.D.), International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address:

Ethnopharmacological Relevance: Tetrapleura tetrapteura Taub. is a leguminous multipurpose tree (Fabaceae) indigenous to tropical Africa. Fruits, seeds and stem bark infusions or decoctions of Tetrapleura tetrapteura Taub. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.026DOI Listing
February 2019

Stem extract of Tabebuia chrysantha induces apoptosis by targeting sEGFR in Ehrlich Ascites Carcinoma.

J Ethnopharmacol 2019 Feb 12. Epub 2019 Feb 12.

Pharmaceutical Analysis Laboratory, SIMS College of Pharmacy, Guntur, India. Electronic address:

Ethnopharmacological Relevance: The plant Tabebuia chrysantha (Jaq.) Nicholson (Bignoniaceae) is commonly known as "Golden Goddess" in the Southern part of India and "Golden Trumpet Tree " in Central America. Stems of this plant have been traditionally used for antioxidant, anti-inflammatory, antimicrobial and anticancer actions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.023DOI Listing
February 2019
1 Read

Sida cordifolia accelerates wound healing process delayed by dexamethasone in rats: Effect on ROS and probable mechanism of action.

J Ethnopharmacol 2019 Feb 12. Epub 2019 Feb 12.

Pharmacognosy and Phytochemistry Laboratory, VNS Group of Institutions, Faculty of Pharmacy, VNS Campus, Vidya Vihar, Neelbud, Bhopal, Madhya Pradesh 462044, India. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2018.07.003DOI Listing
February 2019

Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review.

J Ethnopharmacol 2019 Feb 12. Epub 2019 Feb 12.

Biomedical Research Laboratory, Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.

Ethnopharmacological Relevance: Diabetes and hypertension are pathophysiologically related diseases that co-exist with a wider complex of metabolic diseases having similar set of risk factors. There are numerous ethnopharmacological evidences on the anti-diabetic and/or anti-hypertensive properties of medicinal plants from various parts of the world, which are used as therapies to concomitantly manage diabetes and hypertension.

Aim Of The Review: This article reviewed findings on medicinal plants with both anti-diabetic and anti-hypertensive effects reported in same experimental study to facilitate the development of dual-acting therapies against diabetes and hypertension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.024DOI Listing
February 2019

Aleurites moluccanus and its main active constituent, the flavonoid 2''-O-rhamnosylswertisin, in experimental model of rheumatoid arthritis.

J Ethnopharmacol 2019 Feb 12. Epub 2019 Feb 12.

Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil; Pharmacy Course, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil.

Ethnopharmmacological Relevance: Aleurites moluccana is used in folk medicine to treat pain, fever, asthma, hepatitis, gastric ulcer and inflammatory process in general, and the nut oil had been topically applied to treat arthritis and other joint pain, however the seeds are classified as toxic for oral use.

Aim: Faced with the need for new alternative to treat the symptoms and modify rheumatoid arthritis (RA) the aim of this work was to evaluate the effects of A. moluccanus' leaves dried extract in rats and mice submitted to complete Freund adjuvant (CFA)-induced RA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.014DOI Listing
February 2019

Acid diterpenes from Copaiba oleoresin (Copaifera langsdorffii): Chemical and plasma stability and intestinal permeability using Caco-2 cells.

J Ethnopharmacol 2019 Feb 11;235:183-189. Epub 2019 Feb 11.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP ZIP 14801-902, Brazil. Electronic address:

Ethnopharmacological Relevance: Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no information about major compounds oral absorption to support the traditional use.

Aim Of Study: Considering the potential of copalic (CA) and kaurenoic acid (KA) - major biological activity (in vitro) diterpenes found in the oleoresin, this study aimed to evaluate the intestinal permeability of CA and KA using Caco-2 cells model as predictive test for oral drug absorption.

Materials And Methods: Chemical stability at pH 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.017DOI Listing
February 2019

Can the gastric healing effect of Eugenia punicifolia be the same in male and female rats?

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Department of Physiology, Biosciences Institute, UNESP-São Paulo State University CEP 18618-689, Botucatu, São Paulo, Brazil. Electronic address:

Ethnopharmacological Relevance: Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used as a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, and gastroprotective effects have already been characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.012DOI Listing
February 2019
1 Read

Anti-proliferative and anti-migratory effects of Scutellaria strigillosa Hemsley extracts against vascular smooth muscle cells.

J Ethnopharmacol 2019 Feb 11;235:155-163. Epub 2019 Feb 11.

Hebei Medical University, No. 361 Zhongshan East Road, Shijiazhuang 050017, PR China. Electronic address:

Ethnopharmacological Relevance: The abnormal increase in vascular smooth muscle cell (VSMC) proliferation and migration are critical events in the pathogenesis of cardiovascular diseases (CVDs) including restenosis and atherosclerosis. The dried roots of Scutellaria baicalensis Georgi (common name: Huangqin in China) have been confirmed to possess beneficial effects on CVD by clinical and modern pharmacological studies. Flavonoids in Huangqin exert anti-proliferative and anti-migratory effects. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03788741183424
Publisher Site
http://dx.doi.org/10.1016/j.jep.2019.02.016DOI Listing
February 2019
1 Read

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium.

Ethnopharmacological Relevance: An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.

Materials And Methods: Extracts of different polarity and isolated constituents were tested in vitro for their antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and the chloroquine-sensitive strain P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.019DOI Listing
February 2019

Anti-quorum sensing and anti-biofilm activities of Hypericum perforatum L. extracts against Pseudomonas aeruginosa.

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Department of Biology, Faculty of Arts and Sciences, Marmara University, 34730, Istanbul, Turkey. Electronic address:

Ethnopharmacological Relevance: Hypericum perforatum L. (Hypericaceae) has been used as a traditional therapeutic for skin wounds, burns, cuts and stomach ailments including stomach ache, ulcers for a long time in many societies. Although many studies about its antibacterial properties can be found, there is a lack of studies about its quorum sensing inhibition properties, which effects bacterial vulnerability directly, on Pseudomonas aeruginosa. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.020DOI Listing
February 2019
1 Read

Ovicidal and larvicidal effects of extracts from leaves of Andrographis paniculata (Burm. f.) Wall.ex Nees against field isolates of human hookworm (Ancylostoma duodenale).

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Department of Biological Science, Adamawa State University, P.M.B. 25, Mubi, Nigeria. Electronic address:

Ethnopharmacological Relevance: The whole plant of Andrographis paniculata (Burm. f.) Wall. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.021DOI Listing
February 2019
1 Read
2.998 Impact Factor

The scolicidal activity of the essential oil obtained from the needles of Pinus nigra Arn. subsp. pallasiana (Lamb.) Holmboe on hydatid cyst.

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler 06330, Ankara, Turkey. Electronic address:

Ethnopharmacological Relevance: This study aimed to evaluate the in vitro activity of the essential oil of Pinus nigra subsp. pallasiana against protoscoleces of Echinococcus granulosus sensu lato. In traditional Turkish folk medicine, the essential oils and resin of P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.018DOI Listing
February 2019

Alkamides from Tropaeolum tuberosum inhibit inflammatory response induced by TNF-α and NF-κB.

J Ethnopharmacol 2019 Feb 10;235:199-205. Epub 2019 Feb 10.

Department of Chemistry, Faculty of Sciences, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

Ethno-pharmacological Relevance: Tropaeolum tuberosum, commonly known as "Mashua", is one of the plants most frequently used by Andean (Peruvian-Bolivian) people as food and medicine. It is used as a remedy against a wide range of diseases, especially those related with inflammation.

Objectives: This study aims to identify compounds active against inflammatory related conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.015DOI Listing
February 2019
1 Read

Arbutus unedo L., (Ericaceae) inhibits intestinal glucose absorption and improves glucose tolerance in rodents.

J Ethnopharmacol 2019 Feb 8. Epub 2019 Feb 8.

Laboratoires TBC, Faculty of Pharmaceutical and Biological Sciences, Lille, France. Electronic address:

Ethnopharmacological Relevance: Arbutus unedo L., (Ericaceae) is one of the most traditional plants commonly used to treat diabetes in people living in Eastern Morocco region particularly in Taza and Beni Mellal.

Aim Of The Study: The aim of the study was to find if there is a scientific support to the ethnopharmacological relevance use of Arbutus unedo L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.013DOI Listing
February 2019
2.998 Impact Factor

The antifungal and Cryptococcus neoformans virulence attenuating activity of Pelargonium sidoides extracts.

J Ethnopharmacol 2019 Feb 6;235:122-132. Epub 2019 Feb 6.

Department of Microbiology, Stellenbosch University, Private Bag X1, Stellenbosch 7602, South Africa. Electronic address:

Ethnopharmacological Relevance: Limitations of clinical antifungal treatments and drug-resistance are drivers of the search for novel antifungal strategies. Extracts prepared from the tubers of the medicinal plant, Pelargonium sidoides, are known for their antiviral and antibacterial activities and are used in ethnomedicine for the treatment of acute respiratory infections. Their impact on fungi has not been well characterised. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.008DOI Listing
February 2019
2.998 Impact Factor

Antiplasmodial potential and GC-MS fingerprint of endophytic fungal extracts derived from Cameroonian Annona muricata.

J Ethnopharmacol 2019 Feb 6;235:111-121. Epub 2019 Feb 6.

Antimicrobial & Biocontrol Agents Unit (AmBcAU), Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box: 812, Yaoundé, Cameroon. Electronic address:

Ethnopharmacological Relevance: Annona muricata (Annonaceae) is a commonly used medicinal plants in Cameroonian traditional medicines to treat various diseases including malaria. Previous studies have shown that extracts from this plant have antiplasmodial activity.

Aim Of The Study: This study aimed to explore the endophyic fungi associated with some parts of this plant for their ability to produce antiplasmodial metabolites. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03788741183501
Publisher Site
http://dx.doi.org/10.1016/j.jep.2019.02.010DOI Listing
February 2019
3 Reads

Ethnobotany of medicinal plants used by the Zeliangrong ethnic group of Manipur, northeast India.

J Ethnopharmacol 2019 Feb 6;235:164-182. Epub 2019 Feb 6.

Forest Systematic & Ethnobiology Laboratory, Department of Forestry, North Eastern Regional Institute of Sciences & Technology, Deemed to be University, Nirjuli, Itanagar, Arunachal Pradesh 791109, India.

Ethnopharmacological Relevance: The Zeliangrong people with their yearlong experiences still depend on the medicinal plants for primary healthcare. Some of the medicinal plants used by the community exhibits established pharmacological activities which signify the importance of the traditional knowledge of the tribes. Besides, many other species traditionally used by the tribes assume to have pharmacological potentiality. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03788741183287
Publisher Site
http://dx.doi.org/10.1016/j.jep.2019.02.009DOI Listing
February 2019
3 Reads

Total flavonoid aglycones extract in Radix Scutellariae induces cross-regulation between autophagy and apoptosis in pancreatic cancer cells.

J Ethnopharmacol 2019 Feb 6;235:133-140. Epub 2019 Feb 6.

Department of Hepatobiliary and Pancreatic Surgery, Minhang Branch, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:

Ethnopharmacological Relevance: Radix Scutellariae (RS), the dried root of Scutellariae baicalensis Georgi, known as a herbal medicine in several Asian countries including China, has been widely used to treat inflammation, hypertension, cardiovascular disease as well as cancer. The total flavonoid aglycone extracted (TFAE) was extracted by ethyl acetate and this extraction methodology was optimized and obtained the protection of Chinese patents.

Aim Of The Study: To investigate the underlying mechanism of the chemotherapeutic effects of TFAE in inducing autophagy and apoptosis in pancreatic cancer cells in vitro and in vivo. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03788741183386
Publisher Site
http://dx.doi.org/10.1016/j.jep.2019.02.005DOI Listing
February 2019
4 Reads

Traditional Tibetan medicine Anzhijinhua San attenuates Ovalbumin-induced diarrhea by regulating serotonin signaling system in mice.

J Ethnopharmacol 2019 Feb 6. Epub 2019 Feb 6.

Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai 810008, China; Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai 810008, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 211198, China; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing, Jiangsu 211198, China; School of Traditional Chinese Pharmacy, China Pharmaceutical University; Nanjing, Jiangsu 211198, China. Electronic address:

Ethnopharmacological Relevance: Tibetan medicine has a history of 3800 years. Anzhijinhua San (AZJHS) which is a traditional Tibetan medicine was effective in the treatment of indigestion, anorexia and cold diarrhea etc. However, the effects of AZJHS on allergic diarrhea have not been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.020DOI Listing
February 2019
2 Reads

PKA/β2-AR-Gs/Gi signaling pathway is associated with anti-inflammatory and pro-apoptotic effects of Fuzi and Banxia combination on rats subjected to pressure overload.

J Ethnopharmacol 2019 Feb 6. Epub 2019 Feb 6.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address:

Ethnopharmacological Relevance: Either Aconite Lateralis Radix Praeparata (Fuzi) or Pinelliae Rhizoma (Banxia) exerts anti-inflammatory activity and their combination has long been used in China for treating cardiovascular diseases. However, combination of two drugs is controversially prohibited in clinical prescriptions because it serves a representative incompatible pairs in "eighteen antagonisms". Up to date, whether the combination of Fuzi and Banxia could be used for treating heart failure with preserved ejection fraction (HFpEF) especially charactered by systemic inflammation and the potential mechanisms have not been elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.011DOI Listing
February 2019

Mutagenicity and genotoxicity effects of Verbena officinalis leaves extract in Sprague-Dawley Rats.

J Ethnopharmacol 2019 Feb 6;235:88-99. Epub 2019 Feb 6.

Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. Electronic address:

Ethnopharmacological Relevance: Traditionally, Verbena officinalis L. has been used for reproductive and gynaecological purposes. However, the mutagenicity and genotoxicity of V. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.007DOI Listing
February 2019
1 Read

Fructus Gardeniae-induced gastrointestinal injury was associated with the inflammatory response mediated by the disturbance of vitamin B6, phenylalanine, arachidonic acid, taurine and hypotaurine metabolism.

J Ethnopharmacol 2019 Feb 5;235:47-55. Epub 2019 Feb 5.

School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Longmian Avenue No. 639, 211198 Nanjing, Jiangsu province, China. Electronic address:

Ethnopharmacological Relevance: Fructus Gardenia (FG) is a widely used bitter and cold herb for clearing heat and detoxicating. Currently, toxicity of FG and its relative formula has been reported in many clinical and animal studies. However, no systematic research has been carried out on FG-related gastrointestinal (GI) injury which has been emphasized in China since the Ming Dynasty. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.041DOI Listing
February 2019
1 Read

Genomic and GeneChip expression profiling reveals the inhibitory effects of Amorphophalli Rhizoma in TNBC cells.

J Ethnopharmacol 2019 Feb 4;235:206-218. Epub 2019 Feb 4.

The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang 310006, China. Electronic address:

Ethnopharmacological Relevance: Amorphophalli Rhizoma has been widely used as an adjuvant treatment for advanced or metastatic breast cancer, pancreatic cancer, hepatoma, and malignant lymphoma, but its molecular mechanism of action for treatment of metastatic triple-negative breast cancer (TNBC) is generally poorly understood.

Aim Of The Study: To investigate genomic changes related to the inhibitory effect of Amorphophalli Rhizoma and to elucidate the molecular mechanism of this inhibition in MDA-MB-231 TNBC cells.

Materials And Methods: Gene chip analysis was employed to explore genomic changes caused by Amorphophalli Rhizoma in TNBC cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.004DOI Listing
February 2019
1 Read

Srolo Bzhtang, a traditional Tibetan medicine formula, inhibits cigarette smoke induced airway inflammation and muc5ac hypersecretion via suppressing IL-13/STAT6 signaling pathway in rats.

J Ethnopharmacol 2019 Feb 4. Epub 2019 Feb 4.

Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China. Electronic address:

Ethnopharmacological Relevance: Srolo Bzhtang (SBT), a traditional Tibetan medicine formula, was first documented in the ancient Tibetan medical work Four Medical Tantras (rGyud-bzhi) in the eighth century AD. It has been widely used to treat lung "phlegm-heat" syndromes such as chronic bronchitis and chronic obstructive pulmonary disease (COPD).

Objective: The aim of this study was to evaluate the potential influences of SBT on airway inflammation and mucus secretion and to reveal the underlying mechanism in a rat model of cigarette smoke (CS)-induced chronic bronchitis (CB). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.006DOI Listing
February 2019
1 Read

The effect of Jianpi Yangzheng Xiaozheng Decoction and its components on gastric cancer.

J Ethnopharmacol 2019 Feb 5;235:56-64. Epub 2019 Feb 5.

Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China. Electronic address:

Ethnopharmacological Relevance: Jianpi Yangzheng Xiaozheng Decoction (JPYZXZ) is an empirical compound prescription based on the theory of traditional Chinese medicine. JPYZXZ, which is "Qi-invigorating, spleen-strengthening and stasis-removing," can improve the quality of life of gastric cancer patients and prolong their survival; however, the exact mechanism underlying the antitumor effects of this compound is still not clear.

Aim Of The Study: The aim of this study is to clearly define the effect of JPYZXZ and its components, Jianpi Yangzheng Decoction (JPYZ) and Xiao Zheng San Jie Decoction (XZSJ), on inhibiting the progression of gastric cancer. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03788741183457
Publisher Site
http://dx.doi.org/10.1016/j.jep.2019.02.003DOI Listing
February 2019
2 Reads

Medicinal plants used for contraception in South Africa: A review.

J Ethnopharmacol 2019 Feb 4;235:19-27. Epub 2019 Feb 4.

Indigenous Knowledge Systems (IKS) Centre, Faculty of Natural and Agricultural Sciences, North West University, Private Mail Bag X2046, Mmabatho 2790, North West Province, South Africa. Electronic address:

ETHNOPHARMACOLOGICAL RELEVANCE: The indigenous people of South Africa, such as the Khoisan, Zulu, and Ndebele, have used medicinal plants for contraception. One of the reasons for using contraception among indigenous communities is for child spacing.

Aim Of The Study: The study aims to review medicinal plants used for contraception in South Africa as potential sources for the discovery and development of safe male and female hormonal contraceptives. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03788741183238
Publisher Site
http://dx.doi.org/10.1016/j.jep.2019.02.002DOI Listing
February 2019
6 Reads

Antidiabetic effects of Olea europaea L. leaves in diabetic rats induced by high-fat diet and low-dose streptozotocin.

J Ethnopharmacol 2019 Feb 2;235:1-7. Epub 2019 Feb 2.

Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil. Electronic address:

Ethnopharmacological Relevance: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance, and dyslipidemia. It has broad occurrence worldwide, affecting millions of people, and can cause serious complications. The olive (Olea europaea L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.001DOI Listing
February 2019

Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: Pharmacokinetics and pharmacodynamics outcomes and related mechanisms in rats.

J Ethnopharmacol 2019 Jan 30;235:100-110. Epub 2019 Jan 30.

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region; State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region. Electronic address:

Ethnopharmacological Relevance: Dual antiplatelet therapy (DAPT) with aspirin (ASA) and clopidogrel (CLP) has been consistently shown clinical effectiveness in patients with coronary artery disease. According to the literature, four traditional Chinese medicine (TCM) herbs effective for prevention cardiovascular diseases, namely Radix Salvia Miltiorrhiza (Red sage root, Danshen), Radix Pueraria Lobata (Kudzu root, Gegen), Radix Angelica Sinensis (Angelica root, Danggui), and Rhizoma Ligusticum chuanxiong (Szehuan lovage rhizome, Chuanxiong), are of high potential to be co-administered during DAPT. Since all these herbs are blood vitalizing medicines and can promote blood circulation and eliminate blood stasis, it was hypothesized that they may potentially alter the clinical outcomes of DAPT with clopidogrel and aspirin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.040DOI Listing
January 2019
3 Reads

Suppression of Src and Syk in the NF-κB signaling pathway by Olea europaea methanol extract is leading to its anti-inflammatory effects.

J Ethnopharmacol 2019 Jan 30;235:38-46. Epub 2019 Jan 30.

Department of Integrative Biotechnology and Biomedical Institute for Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Olea europaea L., (Oleaceae) has been used widely in folk medicine in the European Mediterranean islands, India, Asia, and other parts of the world. Although this plant has high ethnopharmacological value for treating inflammatory diseases, the molecular mechanisms of how it inhibits the inflammatory response are not fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.024DOI Listing
January 2019

Chemical and in vitro Toxicity Analysis of a Supercritical Fluid Extraction of Kava kava (Piper methysticum).

J Ethnopharmacol 2019 Jan 30. Epub 2019 Jan 30.

Applied Food Sciences, Inc., 2500 Crosspark Road, Coralville, IA 52241. Electronic address:

Ethnopharmacological Relevance: Kava and kava extracts have shown great potential as a way to minimize anxiety-associated symptoms and to help alleviate pain. Hepatoxicity has been associated with the consumption of kava products. The chemical compounds, kavalactones (KL) and flavokavains (FK) have been implicated in kava's psychotropic and possible hepatotoxic properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.032DOI Listing
January 2019

Chinese Skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats.

J Ethnopharmacol 2019 Jan 29. Epub 2019 Jan 29.

Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 220-702, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Chinese Skullcap (Scutellaria baicalensis Georgi), which is part of the 50 fundamental herbs of Traditional Chinese Medicine, has been extensively used in the several East Asian countries to treat pyrexia, micturition disorder and inflammation. Although skullcap has effective properties on various diseases, the effects and molecular mechanism of Chinese Skullcap on BPH are still needed for better understanding.

Aim Of The Study: In present study, we aimed to demonstrate the efficacy of Chinese Skullcap root extract (SRE) in testosterone-induced BPH rats and investigate the exact regulatory mechanism involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.039DOI Listing
January 2019

Brain metabonomics study of the antidepressant-like effect of Xiaoyaosan on the CUMS-depression rats by H NMR analysis.

J Ethnopharmacol 2019 Jan 29;235:141-154. Epub 2019 Jan 29.

Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, Shanxi, China; Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Taiyuan 030006, Shanxi, China. Electronic address:

Ethnopharmacological Relevance: Xiaoyaosan (XYS), a famous TCM prescription with a long history of clinical use for relieving a wide variety of depression symptoms, consists of Radix Bupleuri (Bupleurum chinense DC.), Radix Angelicae Sinensis (Angelica sinensis (Oliv.) Diels), Radix PaeoniaeAlba (Paeonia lactiflora Pall. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.018DOI Listing
January 2019

Cynomorium songaricum Rupr demonstrates phytoestrogenic or phytoandrogenic like activities that attenuates benign prostatic hyperplasia via regulating steroid 5-α-reductase.

J Ethnopharmacol 2019 Jan 29;235:65-74. Epub 2019 Jan 29.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China. Electronic address:

Ethnopharmacological Relevance: Cynomorium songaricum Rupr. (CS) belongs to the genus of parasitic perennial flowering plants, mostly used in Chinese traditional medicine for benign prostatic hyperplasia (BPH) treatment. BPH is a chronic disease in men that both androgen and estrogen play a crucial role in promoting its development via their receptors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.038DOI Listing
January 2019

Safety investigation of Pulsatilla chinensis saponins from chronic metabonomic study of serum biomedical changes in oral treated rat.

J Ethnopharmacol 2019 Jan 28. Epub 2019 Jan 28.

Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang 330004, PR China. Electronic address:

Ethnopharmacological Relevance: Pulsatilla chinensis (Bunge) Regel is a valuable traditional Chinese medicine which is widely used for the treatment of schistosomiasis, inflammatory, bacterial infections. In recent years, P chinensis has been reported to exhibit antitumor activities. However, the mechanisms underlying its toxic effects remain largely unresolved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.035DOI Listing
January 2019

Extract and fraction of Cassia occidentalis L. (a synonym of Senna occidentalis) have osteogenic effect and prevent glucocorticoid-induced osteopenia.

J Ethnopharmacol 2019 Jan 28;235:8-18. Epub 2019 Jan 28.

Division of Endocrinology, CSIR-Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow 226031, India. Electronic address:

Ethnopharmacological Relevance: Cassia occidentalis L., a synonym of Senna occidentalis (belongs to Caesalpiniaceae family) is an annual plant. Pursuing a lead from a folk practice prevalent since the late nineteenth century in Andhra Pradesh, a Southern state of India, of use of Cassia occidentalis leaf and stem for treating patients with fracture and bone diseases, we have not only confirmed its fracture healing activity but also demonstrated efficacy in preventing glucocorticoid-induced osteoporosis (GIO), the commonest form of medication-induced bone loss caused chiefly due to impairment of bone formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.029DOI Listing
January 2019
4 Reads
2.998 Impact Factor

A network pharmacology approach to investigate the blood enriching mechanism of Danggui buxue Decoction.

J Ethnopharmacol 2019 Jan 28. Epub 2019 Jan 28.

Nanjing University of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae and Key Laboratory of Chinese Medicinal Resources Recycling Utilization, State Administration of Traditional Chinese Medicine; Nanjing 210023, Jiangsu Province, China.

Ethnopharmacological Relevance: Danggui buxue Decoction (DBD) has been frequently used to treat with blood deficiency which consisted of Angelica sinensis (Oliv.) Diels. (Danggui, DG) and Astragalus membranaceus (Fisch. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03788741183343
Publisher Site
http://dx.doi.org/10.1016/j.jep.2019.01.027DOI Listing
January 2019
1 Read

Evaluation of anti-nociceptive and anti-inflammatory activities of the methanol extract of Holigarna caustica (Dennst.) Oken leaves.

J Ethnopharmacol 2019 Jan 28. Epub 2019 Jan 28.

Ethnobotany and Pharmacognosy Lab, Department of Botany, University of Chittagong, Chittagong 4331, Bangladesh. Electronic address:

Ethnopharmacological Relevance: Holigarna caustica (Dennst.) is commonly used in the traditional medicine to treat a variety of painful conditions such as eye irritation, inflammation, arthritis, skin diseases, cuts, and wounds.

Aim Of The Study: The present study was undertaken to investigate the anti-nociceptive and anti-inflammatory activities of the methanol extract of H. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.025DOI Listing
January 2019
1 Read

Interaction of clopidogrel and fufang danshen dripping pills assay in coronary heart disease based on non-target metabolomics.

J Ethnopharmacol 2019 Jan 28;234:189-196. Epub 2019 Jan 28.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China. Electronic address:

Ethnopharmacological Relevance: Clopidogrel is the recommended treatment by current clinical practice guidelines to prevent adverse cardiovascular events in patients with coronary heart disease (CHD), but this treatment regimen still fails and 5-40% patients display inadequate antiplatelet responses. Fufang Danshen Dripping Pill (FDDP), a Chinese patient drug, was used as the combination with clopidogrel to improve the therapeutic effect. However, the mechanism of the interaction between clopidogrel and FDDP has not been elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.030DOI Listing
January 2019

Evaluation of Polyherbal Ayurvedic Formulation 'Peedantak Vati' for Anti-inflammatory and Analgesic Properties.

J Ethnopharmacol 2019 Jan 28. Epub 2019 Jan 28.

Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, India.

Ethnopharmacological Relevance: Peedantak Vati (PV) is a polyherbal ayurvedic formulation, which is regularly prescribed by the ayurvedic practitioner for the inflammatory disorders and joints pain in India. It is composed of 23 different herbs and minerals, described in ayurvedic text for their anti-inflammatory and analgesic properties.

Aim Of The Study: To investigate anti-inflammatory and anti-nociceptive potential of 'Peedantak Vati' using in vitro and in vivo methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.028DOI Listing
January 2019
1 Read
2.998 Impact Factor

Cytotoxicity of the crude extract and constituents of the bark of Fagara tessmannii towards multi-factorial drug resistant cancer cells.

J Ethnopharmacol 2019 Jan 29;235:28-37. Epub 2019 Jan 29.

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address:

Ethnopharmacological Relevance: Fagara tessmannii Engl. is an African medicinal plant used in Cameroonian traditional medicine to treat various types of cancers.

Aim Of The Study: This work was designed to determine the cytotoxicity of the crude extract (FTB), fractions (FTBa-d) and compounds isolated from the bark of Fagara tessmannii, namely lupeol (1), fagaramide (2), zanthoxyline (3), hesperidin (4), nitidine chloride (5), fagaridine chloride (6), and β-sitosterol-3-O-β--glucopyranoside (7). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.031DOI Listing
January 2019
1 Read

Neutrophil elastase inhibitory effects of pentacyclic triterpenoids from Eriobotrya japonica (loquat leaves).

J Ethnopharmacol 2019 Jan 28. Epub 2019 Jan 28.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Ethnopharmacological Relevance: Eriobotrya japonica, a traditional herbal medicine in China and Japan, has long been used to treat chronic bronchitis and coughs.

Aim Of The Study: Pentacyclic triterpenoids (PTs), especially ursolic acid (UA), have been found as reversibly and competitively human neutrophil elastase (HNE) inhibitors. However, the limited solubility and poor bioavailability of PTs hinder their clinical use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.037DOI Listing
January 2019
1 Read

Sub-chronic oral toxicity of the aqueous extract of lithospermi radix in Fischer 344 rats.

J Ethnopharmacol 2019 Jan 28. Epub 2019 Jan 28.

Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Lithospermi radix has been prescribed in traditional folk medicine to treat diverse diseases like cancer.

Aim Of The Study: The present study assessed the sub-chronic oral toxicity of an aqueous extract of lithospermi radix (WLR) in Fischer 344 rats over a period of 13 weeks.

Materials And Methods: The chemical compositions of WLR were analyzed using ultra-high performance liquid chromatography (UHPLC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.034DOI Listing
January 2019

Assessment of 28-day oral toxicity and antipyretic activity of the saline extract from Pilosocereus gounellei (Cactaceae) stem in mice.

J Ethnopharmacol 2019 Jan 28;234:96-105. Epub 2019 Jan 28.

Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. Electronic address:

Ethnopharmacological Relevance: Pilosocereus gounellei is a plant found in the Brazilian Caatinga and is popular due to its traditional uses in the treatment of inflammation. The present study was conducted to investigate the sub-acute toxicity of the saline extract from the stem of P. gounellei. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.01.036DOI Listing
January 2019