7,827 results match your criteria Journal of Endodontics [Journal]


The Effect of Crown Lengthening on the Outcome of Endodontically Treated Posterior Teeth: 10-year Survival Analysis.

J Endod 2019 Apr 17. Epub 2019 Apr 17.

Department of Endodontics, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Introduction: The purpose of this study was to investigate the effect of a crown lengthening (CL) procedure and the crown-root ratio after CL on the long-term survival of endodontically treated teeth (ETT).

Methods: Permanent posterior teeth with opposing dentition that had received adequate nonsurgical root canal treatment (NSRCT) and a full-coverage crown between January 1, 2006, and January 1, 2016 were included in this retrospective study. The data collected included dates of the NSRCT, time of extraction if extracted, age, sex, location, the crown-root ratio after CL, and the presence of a lesion. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.006DOI Listing

Resilon: Assessment of Degraded Filling Material in Nonhealed Cases.

J Endod 2019 Apr 17. Epub 2019 Apr 17.

Department of Endodontics, UNC School of Dentistry, Chapel Hill, North Carolina.

Introduction: The Resilon obturation system (Pentron Clinical Technologies, Wallingford, CT) was discontinued a few years after its introduction as an alternative to traditional gutta-percha and sealer. Ex vivo models support anecdotal reports of degraded Resilon filling material; however, there is no previous clinical report of this degradation. This may represent a significant health concern for the patient and contribute to a higher clinical failure rate of Resilon-obturated root canals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00992399193012
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http://dx.doi.org/10.1016/j.joen.2019.02.019DOI Listing
April 2019
3 Reads

Accuracy of Different Imaging CBCT Systems for the Detection of Natural External Radicular Resorption Cavities: An Ex Vivo Study.

J Endod 2019 Apr 16. Epub 2019 Apr 16.

School of Life Sciences - Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.

Objective: The aim of this study was to compare the sensitivity and specificity of 3 different systems of cone-beam computed tomography (CBCT) in the detection of natural external root resorption (ERR) cavities using microtomography as the gold standard.

Method: A sample of 126 ex vivo teeth were submitted to a microtomography examination to verify the presence/absence of ERR cavities. Then, they were divided into the control group: 85 teeth that did not present with an ERR cavity; and experimental group: 41 teeth that presented with 1 or more ERR cavities. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.020DOI Listing

Root Canal Disinfection by Single- and Multiple-instrument Systems: Effects of Sodium Hypochlorite Volume, Concentration, and Retention Time.

J Endod 2019 Apr 10. Epub 2019 Apr 10.

Department of Endodontics, Faculty of Dentistry, Estácio de Sá University, Rio de Janeiro, Rio de Janiero, Brazil.

Introduction: This ex vivo study evaluated the intracanal bacterial reduction promoted by chemomechanical preparation using a single-file technique varying the volume, concentration, and retention time of sodium hypochlorite (NaOCl) irrigation in comparison with a multifile system.

Methods: Palatal roots from extracted maxillary first molars were selected and anatomically matched based on microcomputed tomographic analysis for group distribution. The canals were contaminated with a fresh mixed bacterial culture grown in anaerobiosis and recently obtained from a tooth with apical periodontitis. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.017DOI Listing

Human Pulp Fibroblast Implication in Phagocytosis via Complement Activation.

J Endod 2019 Apr 3. Epub 2019 Apr 3.

Aix Marseille University, Centre National de la Recherche Scientifique, Institute of Movement Sciences, Marseille, France. Electronic address:

Introduction: Previous works have shown that human pulp fibroblasts synthetize all complement components. Local complement activation in the dental pulp is known to be involved in inflammation and regeneration and also in pathogen destruction through membrane attack complex formation. Bacterial elimination by complement-mediated phagocytosis implies microorganism opsonization with the complement C3b protein, which is recognized by specific phagocytic cell CR1 receptors for subsequent intracellular destruction. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.023DOI Listing
April 2019
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Changes in Geometry and Transportation of Root Canals with Severe Curvature Prepared by Different Heat-treated Nickel-titanium Instruments: A Micro-computed Tomographic Study.

J Endod 2019 Apr 3. Epub 2019 Apr 3.

Department of Restorative Dentistry, Dental School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Introduction: The aim of this study was to compare the shaping ability of 4 different nickel-titanium systems, considering their variation in alloy treatment, kinematics, and design, used to prepare canals with severe curvature using micro-computed tomographic analysis.

Methods: Thirty-two mesial roots of mandibular molars with severe curvature were matched based on similar morphologic dimensions and assigned to 4 experimental groups (n = 8) according to the canal preparation: ProTaper Next (PTN; Dentsply Maillefer, Ballaigues, Switzerland), Reciproc (RC; VDW GmbH, Munich, Germany), Reciproc Blue (RCB, VDW GmbH), and TRUShape (TRU; Dentsply Tulsa Dental Specialties, Tulsa, OK) systems. Changes in 2-dimensional (area and perimeter) and 3-dimensional (volume, surface area, and structure model index) morphologic parameters as well as canal transportation were compared among groups using the analysis of variance post hoc Tukey tests with the significance level set at 5%. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.018DOI Listing
April 2019
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Ex Vivo Detection of Apical Delta in Premolars: A Comparative Study Using Periapical Radiography, Cone-beam Computed Tomography, and Micro-computed Tomography.

J Endod 2019 Apr 3. Epub 2019 Apr 3.

Department of Stomatology (Oral Diagnosis), Faculty of Dentistry, Federal University of Goias, Goiânia, Goiás, Brazil. Electronic address:

Introduction: Imaging methods are essential for the correct identification of root canal anatomy, which is a key factor for successful endodontic therapy. This study aimed to evaluate the performance of periapical radiography (PR) and cone-beam computed tomographic (CBCT) imaging in identifying the apical delta (AD) using micro-computed tomographic imaging as the gold standard.

Methods: PR and CBCT images of 110 human premolars (120 root canals) were obtained using the VistaScan digital intraoral system (Durr Dental, Beitigheim-Bissinger, Germany) and the 3D Accuitomo CBCT unit (J Morita, Kyoto, Japan), respectively. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.022DOI Listing

Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla.

J Endod 2019 Apr 3. Epub 2019 Apr 3.

Division of Oral Biological Sciences, Department of Molecular Cell Biology and Oral Anatomy, Kyushu University Graduate School of Dental Science, Fukuoka, Japan. Electronic address:

Introduction: Stem cells isolated from the root apical papilla of human teeth (stem cells from the apical papilla [SCAPs]) are capable of forming tooth root dentin and are a feasible source for bioengineered tooth root regeneration. In this study, we examined the effect of acetylsalicylic acid (ASA) on odontogenic differentiation of SCAPs in vitro and in vivo.

Methods: SCAPs were cultured under odontogenic conditions supplemented with or without ASA. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.016DOI Listing

Comparator Choice in Studies Testing Endodontic Instrument Fatigue Resistance: A Network Analysis.

J Endod 2019 Apr 2. Epub 2019 Apr 2.

Department of Operative and Preventive Dentistry, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany. Electronic address:

Aims: Endodontic instruments are frequently compared against each other for their cyclic fatigue resistance (CFR). It is unclear what drives the comparator choice in CFR studies, and how comparators and comparisons have evolved over time. We aimed at evaluating CFR study networks, hypothesizing that indications and instrument properties (alloy, manufacturer) drive comparisons. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.015DOI Listing
April 2019
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Novel Activated Microbubbles-based Strategy to Coat Nanoparticles on Root Canal Dentin: Fluid Dynamical Characterization.

J Endod 2019 Apr 2. Epub 2019 Apr 2.

Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Introduction: Activated microbubbles (MBs) have the potential to deliver nanoparticles in complex microspaces such as root canals. The objective of the study is to determine the fluid dynamical parameters associated with ultrasonic, sonic, and manual activation of MBs in simulated root canals and to assess the effectiveness of surface coating formed by delivering chitosan nanoparticles using activated MBs within root canals in extracted teeth.

Methods: In stage 1, polydimethylsiloxane models were fabricated to determine the physical effects of MBs agitated manually (MM), sonically (MS), and ultrasonically (MU). Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.011DOI Listing

Microcomputed Assessment of Transportation, Centering Ratio, Canal Area, and Volume Increase after Single-file Rotary and Reciprocating Glide Path Instrumentation in Curved Root Canals: A Laboratory Study.

J Endod 2019 Mar 29. Epub 2019 Mar 29.

Department of Anatomy, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Introduction: The aim of this study was to compare the transportation and centering abilities of the ProGlider (PG; Dentsply-Sirona, Ballaigues, Switzerland), WaveOne Gold Glider (WOGG; Dentsply-Sirona), and R-Pilot (RP; VDW, Munich, Germany) file systems and the changes in the structure model index (SMI), surface area, and root canal volume (after creating the glide path in the mandibular first molar teeth's mesial canals with moderate curvature) using the micro-computed tomographic (micro-CT) method.

Methods: In the present study, 24 mandibular first molar teeth with 2 separate mesial canals and moderate (10°-20°) curvature were used. After scanning with micro-CT imaging before the procedure, the teeth were divided into 3 groups, PG, WOGG, and RP (n = 10/each group), followed by the glide path procedure. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.012DOI Listing

Effectiveness of Gutta-percha/Sealer Removal during Retreatment of Extracted Human Molars Using the GentleWave System.

J Endod 2019 Mar 30. Epub 2019 Mar 30.

Texas A & M College of Dentistry, Dallas, Texas.

Introduction: The goal of endodontic retreatment is to address the etiology responsible for failure. In order to achieve this, the contents of the previous treatment must be removed. The aim of this study was to compare the effectiveness of the removal of residual obturation material (gutta-percha and sealer) using side-vented needle, EndoVac, and GentleWave (Sonendo, Inc, Laguna Hills, CA) irrigation protocols. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.009DOI Listing
March 2019
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Evaluation of Blood Clot, Platelet-rich Plasma, Platelet-rich Fibrin, and Platelet Pellet as Scaffolds in Regenerative Endodontic Treatment: A Prospective Randomized Trial.

J Endod 2019 Mar 29. Epub 2019 Mar 29.

Department of Pediatric Dentistry, Hacettepe Univesity, Faculty of Dentistry, Ankara, Turkey; Department of Pediatric Dentistry, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Introduction: Regenerative endodontic procedures (REPs) using autologous platelet concentrates as scaffolds can improve the biologic outcome of treatment. This prospective, randomized trial compared the clinical and radiographic performance of REPs using platelet-rich plasma (PRP), platelet-rich fibrin (PRF), a platelet pellet (PP), and an induced blot clot (BC).

Methods: Sixty-seven healthy children (aged 8-11 years) with 88 immature necrotic incisors were included. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.002DOI Listing
March 2019
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Comparison of In Vitro Torque Generation during Instrumentation with Adaptive Versus Continuous Movement.

J Endod 2019 Mar 29. Epub 2019 Mar 29.

Department of Conservative Dentistry, School of Dentistry, Dental Research Institute, Pusan National University, Yangsan, Korea. Electronic address:

Introduction: The purpose of this in vitro study was to compare the torque generated by continuous and adaptive movements of 2 nickel-titanium rotary file systems.

Methods: Forty-five simulated resin blocks with an S-shaped canal were randomly divided into 3 groups (n = 15) according to the file system and kinematics: the K3XF rotary system (Kerr Endodontics, Orange, CA) with continuous rotary movement, the K3XF with adaptive movement, and the Twisted File (Kerr Endodontics) adaptive file with adaptive movement. After creating a glide path, the canal was instrumented to the same size (. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.010DOI Listing

Neutrophil Extracellular Traps Exert Potential Cytotoxic and Proinflammatory Effects in the Dental Pulp.

J Endod 2019 Mar 28. Epub 2019 Mar 28.

Oral Biology, Birmingham Dental School and Hospital, College of Medical and Dental Sciences, Birmingham, United Kingdom. Electronic address:

Introduction: Neutrophil extracellular traps (NETs) are an important innate immune mechanism aimed at limiting the dissemination of bacteria within tissues and localizing antibacterial killing mechanisms. There is significant interest in the role of NETs in a range of infectious and inflammatory diseases; however, their role in diseased pulp has yet to be explored. Our aim was to determine their relevance to infected pulp and how their components affect human dental pulp cell (HDPC) responses. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.014DOI Listing
March 2019
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Cyclic Fatigue and Torsional Failure of EdgeTaper Platinum Endodontic Files at Simulated Body Temperature.

J Endod 2019 Mar 28. Epub 2019 Mar 28.

Restorative and Prosthetic Dental Sciences, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia, and King Abdullah International Medical Research Centre, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Introduction: The aim of this in vitro study was to compare the cyclic fatigue resistance and torsional resistance of EdgeTaper Platinum (ETP) with those of ProTaper Gold (PTG) at simulated body temperature.

Methods: ETP and PTG files with #25 tip size were selected. Cyclic fatigue tests were performed in a stainless steel artificial canal until file fracture occurred. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.008DOI Listing
March 2019
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255-nm Light-emitting Diode Kills Enterococcus faecalis and Induces the Production of Cellular Biomarkers in Human Embryonic Palatal Mesenchyme Cells and Gingival Fibroblasts.

J Endod 2019 Mar 28. Epub 2019 Mar 28.

Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, Iowa; Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, Iowa. Electronic address:

Introduction: The successful treatment of infected or inflamed endodontic tissues requires chemomechanical debridement of the canal spaces and proper sealing of the coronal and apical canal openings. Only a few methods are available to further disinfect areas or initiate regeneration of local tissues. In this study, we assessed the ability of 255-nm and 405-nm light-emitting diode (LED) treatment to kill planktonic cultures of Enterococcus faecalis and induce the production of cellular biomarkers related to endodontic tissue regeneration. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.016DOI Listing

Accuracy of 3-dimensional-printed Endodontic Surgical Guide: A Human Cadaver Study.

J Endod 2019 Mar 28. Epub 2019 Mar 28.

Department of Endodontics, Biomedical Sciences, Texas A&M College of Dentistry, Dallas, Texas. Electronic address:

Introduction: Cone-beam computed tomographic (CBCT)-based 3-dimensional-printed surgical guides, such as those used in implant placement and orofacial surgery, allow for accurate planning and performance of surgical procedures. The objective of this study was to evaluate the accuracy of CBCT-designed surgical guides for use during endodontic surgery.

Methods: A split-mouth design was conducted using 48 roots in a cadaver model. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.005DOI Listing
March 2019
1 Read
3.375 Impact Factor

EDTA Enhances Stromal Cell-derived Factor 1α-induced Migration of Dental Pulp Cells by Up-regulating Chemokine Receptor 4 Expression.

J Endod 2019 Mar 26. Epub 2019 Mar 26.

State Key Laboratory of Oral Diseases, National Clinical Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Introduction: In regenerative endodontics, irrigation is an important step to ensure the success of treatment. EDTA as a common irrigant has been recommended in the American Associations of Endodontists guidelines. It has been suggested that EDTA-treated dentin slices could increase the attachment, differentiation, and migration of dental pulp stem cells. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.006DOI Listing

Determination of the Initial Apical Canal Diameter by the First File to Bind or Cone-beam Computed Tomographic Measurements Using Micro-computed Tomography as the Gold Standard: An Ex Vivo Study in Human Cadavers.

J Endod 2019 Mar 26. Epub 2019 Mar 26.

Department of Endodontics, Faculty of Dentistry, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Introduction: This study evaluated the accuracy and reliability of the tactile perception of the first apical binding file (FABF) and cone-beam computed tomographic (CBCT) imaging in estimating the canal diameter at the working length (WL).

Methods: Ten anterior mandible segments were obtained from cadavers maintained in formalin and scanned using CBCT and high-resolution micro-computed tomographic (micro-CT) imaging. Scans were used to measure the smallest canal diameter of 38 mandibular incisors at 1 mm short of the root apex. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.020DOI Listing

Distance and Bone Density between the Root Apex and the Mandibular Canal: A Cone-beam Study of 9202 Roots from a Brazilian Population.

J Endod 2019 Mar 22. Epub 2019 Mar 22.

Postgraduate Program in Dentistry, Estácio de Sá University, Rio de Janeiro, Brazil. Electronic address:

Introduction: Accidental damage to the inferior alveolar nerve is of concern during endodontic treatment of the posterior mandible teeth, and a careful evaluation of the relationship between the apices and the mandibular canal (MC) is mandatory to prevent iatrogenic complications. This study aimed to assess the distance between the root apices of posterior teeth and the MC and the bone density in such areas.

Methods: One thousand retrospective cone-beam computed tomographic scans were randomly selected from a private oral radiologic clinic database. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.004DOI Listing

Endothelial Dysfunction Marker Variation in Young Adults with Chronic Apical Periodontitis before and after Endodontic Treatment.

J Endod 2019 Mar 22. Epub 2019 Mar 22.

Department of Surgical Sciences, Dental School, University of Turin, Turin, Italy. Electronic address:

Introduction: Cardiovascular diseases are the leading cause of mortality worldwide. Apical periodontitis (AP) has been associated with an increased risk of cardiovascular diseases. A correlation has been shown between chronic AP and endothelial dysfunction (ED), but there is no evidence to indicate ED improves after endodontic treatment in patients with periapical lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00992399193008
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http://dx.doi.org/10.1016/j.joen.2019.01.018DOI Listing
March 2019
8 Reads

The Effect of Submucosal Injection of Corticosteroids on Pain Perception and Quality of Life after Root Canal Treatment of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial.

J Endod 2019 Mar 22. Epub 2019 Mar 22.

Department of Orthodontics, Faculty of Dentistry, Ilam University of Medical Sciences, Ilam, Iran.

Introduction: The aim of the present investigation was to study the effect of local infiltration of corticosteroids on postoperative pain and quality of life (QOL) in teeth with irreversible pulpitis after 1-visit endodontic treatment.

Methods: In this double-blind randomized clinical trial, 242 healthy patients with irreversible pulpitis undergoing 1-visit endodontic treatment were included. Forty-five patients were lost during the follow-up, and the remaining 197 patients were followed for 7 days (67 patients in the placebo group, 66 in the long-acting betamethasone group, and 64 in the dexamethasone group). Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.005DOI Listing

Long-term Outcomes of Endodontic Treatment Performed with Resilon/Epiphany.

J Endod 2019 Mar 21. Epub 2019 Mar 21.

Department of Endodontics, University of North Carolina School of Dentistry, Chapel Hill, North Carolina. Electronic address:

Introduction: Resilon (Resilon Research LLC, Madison, CT) with Epiphany Sealer (Pentron Clinical Technologies, Wallingford, CT) was introduced into the market in 2004 as a new method of root canal obturation. This material as well as the traditionally used gutta-percha with AH Plus sealer (Dentsply Maillefer, Tulsa, OK) were in use over a 9-year span in the University of North Carolina endodontic clinics. Although Resilon was initially thought to create a "monoblock" seal between the material and the canal, in vitro studies later suggested this concept not to be true. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.019DOI Listing

Accuracy in Detecting Artificial Root Resorption in Panoramic Radiography versus Tomosynthetic Panoramic Radiographs.

J Endod 2019 Mar 21. Epub 2019 Mar 21.

Section of Oral Radiology, Department of Oral and Maxillofacial Surgery, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address:

Introduction: The aim of this study was to compare the detection accuracy of panoramic radiography (PAN) and tomosynthetically reconstructed panoramic radiography (TPAN) for the detection of artificial external root resorption in a multiobserver approach.

Methods: Thirty-six teeth in 5 dry human mandibles were prepared with artificial root resorption by means of diamond bur defects (0.8, 1. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.009DOI Listing

Regenerative Endodontics: A Systematic Analysis of the Failed Cases.

J Endod 2019 Mar 21. Epub 2019 Mar 21.

Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio.

Introduction: The aim of this systematic review was to analyze failed cases of regenerative endodontic treatment (RET) reported in the literature in terms of etiology, diagnosis, treatment protocols, signs of failure, and additional endodontic interventions.

Methods: Electronic searches were performed in PubMed, Web of Science, and ProQuest Dissertations & Theses databases. All in vivo publications in humans that reported at least 1 failed case of RET were included in this systematic review. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.004DOI Listing

Characterization of Leachates from 6 Root Canal Sealers.

J Endod 2019 Mar 21. Epub 2019 Mar 21.

Department of Dental Materials, Faculty of Dentistry, Academisch Centrum Tandheelkunde Amsterdam, Amsterdam, The Netherlands.

Introduction: The aim of this study was to evaluate 6 different endodontic sealers by characterizing their leachates and comparing their solubility in water over a 4-week period.

Methods: The solubility of each sealer (Apexit Plus [Ivoclar Vivadent AG, Schaan, Liechtenstein], MTA Fillapex [Angelus Dental, Londrina, Brazil], AH Plus [Dentsply DeTrey, Konstanz, Germany], BioRoot RCS [Septodont, Saint-Maur-des-Fossés, France], Total Fill [FKG Dentaire SA, La Chaux-de-Fonds, Switzerland], and Obturys [Itena, Paris, France]) was tested according to the ISO specification 6876:2012 over a 4-week period. Residues were chemically analyzed using energy-dispersive X-ray spectroscopy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00992399193004
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http://dx.doi.org/10.1016/j.joen.2019.01.011DOI Listing
March 2019
5 Reads

Effect of Truss Access and Artificial Truss Restoration on the Fracture Resistance of Endodontically Treated Mandibular First Molars.

J Endod 2019 Mar 21. Epub 2019 Mar 21.

Department of Endodontics, Faculty of Dental Medicine, Al-Azhar University, Cairo, Egypt.

Introduction: This study evaluated the effects of traditional and truss access cavity preparations in addition to artificial truss restoration on the fracture resistance of endodontically treated mandibular molars.

Methods: A total of 66 recently extracted, intact mandibular first molars were collected from patients between 20 and 45 years of age. After the preparation of a mesio-occluso-distal cavity in all teeth, the teeth were randomly grouped into the following 4 groups according to the access cavity design: traditional access cavity, artificial truss restoration, truss access cavity, and control groups. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.007DOI Listing

Incidence of Pulpal Complications after Diagnosis of Vital Cracked Teeth.

J Endod 2019 Mar 21. Epub 2019 Mar 21.

Department of Restorative Dentistry, National Dental Centre, Singapore.

Introduction: This retrospective cohort study aimed to observe the incidence of pulpitis and necrosis in teeth with cracks that were not endodontically treated.

Methods: One hundred eighty-four patients with 199 cracked teeth that were diagnosed with reversible pulpitis and were treated from January 2010 to December 2013 at National Dental Centre, Singapore, were recruited. Cracked teeth were identified by inspection, transillumination, and positive bite tests. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.003DOI Listing

Orthodontic-induced External Root Resorption of Endodontically Treated Teeth: A Meta-analysis.

J Endod 2019 Mar 20. Epub 2019 Mar 20.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Introduction: The difference in the amount of orthodontic-induced external root resorption (OIERR) of endodontically treated teeth (ETT) compared with vital pulp teeth (VPT) treatment is controversial. This systematic review and meta-analysis assessed the available evidence regarding OIERR of ETT compared with VPT.

Methods: PubMed, Scopus, MEDLINE, Web of Science, and Cochrane databases were searched up to May 2018 to retrieve relevant studies. Read More

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http://dx.doi.org/10.1016/j.joen.2019.02.001DOI Listing

The Effect of Different Cavity Designs and Temporary Filling Materials on the Fracture Resistance of Upper Premolars.

J Endod 2019 Mar 14. Epub 2019 Mar 14.

Department of Restorative Dentistry, Faculty of Dentistry, Erciyes University, Kayseri, Turkey.

Introduction: The aim of this study was to compare the fracture resistance of upper premolars undergoing root canal treatment that had been temporarily restored with 4 different temporary filling materials.

Methods: This study was based on 120 extracted upper premolars. Eight teeth were left intact and served as the negative control group. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.010DOI Listing
March 2019
1 Read

A Diagnostic Accuracy Study of Laser Doppler Flowmetry for the Assessment of Pulpal Status in Children's Permanent Incisor Teeth.

J Endod 2019 Mar 14. Epub 2019 Mar 14.

Hamad Medical Corporation, Doha, Qatar.

Introduction: The aim of this study was to assess whether laser Doppler flowmetry is more accurate than the conventional pulp sensibility tests (electric pulp test and ethyl chloride) in assessing the pulpal status of permanent anterior teeth in children and to identify the laser Doppler flowmetry's Flux cut-off threshold.

Methods: A cross-sectional diagnostic accuracy study with randomization was performed and included 74 participants (8- to 16-year-old children). Participants had 1 maxillary central or lateral incisor with either a completed root canal treatment or an extirpated pulp and a contralateral tooth with vital pulp. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.017DOI Listing
March 2019
2 Reads

Cytotoxicity and Genotoxicity of a New Intracanal Medicament, 2-hydroxyisocaproic Acid-An In Vitro Study.

J Endod 2019 Mar 14. Epub 2019 Mar 14.

Graduate Endodontics, University of Detroit Mercy School of Dentistry, Detroit, Michigan.

Introduction: A successful outcome of root canal therapy relies on effective disinfection of the root canal system, including the use of intracanal medicaments, which vary in their bactericidal and cytotoxic properties. Assessing the benefits and risks associated with the use of these medicaments is of extreme importance, especially in regenerative endodontic procedures, because residual stem cells may be harmed. In this study, we tested the cytotoxicity and genotoxicity of a novel agent, 2-hydroxyisocaproic acid (HICA), and compared its properties with those of a well-established medicament, calcium hydroxide. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.012DOI Listing
March 2019
1 Read

Vitality Tests for Pulp Diagnosis of Traumatized Teeth: A Systematic Review.

J Endod 2019 Mar 13. Epub 2019 Mar 13.

Department of Endodontics, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil; Department of Endodontics, Grande Rio University, Rio de Janeiro, Rio de Janeiro, Brazil.

Introduction: The objective of this systematic review was to evaluate the efficacy of vitality tests (pulse oximetry and flowmetry) in the pulpal diagnosis of traumatized teeth in comparison with sensibility tests.

Methods: This review was registered in the PROSPERO database (CRD42018097361) and was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. An electronic systematic search of the literature was performed in the PubMed (Medline), Scopus, Web of Science, Cochrane Library, Lilacs, and Gray Literature databases and the reference lists of articles published until May 2018. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.014DOI Listing

A Novel Prefabricated Grid for Guided Endodontic Microsurgery.

J Endod 2019 Mar 12. Epub 2019 Mar 12.

Department of Endodontics, Texas A&M College of Dentistry, Dallas, Texas. Electronic address:

Introduction: This study aimed to introduce a novel method using cone-beam computed tomographic (CBCT) imaging and prefabricated grids to guide apical access during endodontic microsurgery and to compare its accuracy with that of the nonguided method.

Methods: Forty-two roots from human cadaver jaws were selected. Twenty-one were randomly assigned to the experimental group (grid based) and their contralateral counterparts to the control group (nonguided). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00992399193007
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http://dx.doi.org/10.1016/j.joen.2019.01.015DOI Listing
March 2019
3 Reads

Genetic Polymorphisms in RANK and RANKL are Associated with Persistent Apical Periodontitis.

J Endod 2019 Mar 11. Epub 2019 Mar 11.

Department of Restorative Dentistry School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Introduction: The outcome of root canal treatment has been reported as intimately related to the host response. Genetic polymorphisms might be associated with apical periodontitis repair. The aim of this study was to evaluate the association between receptor activator of nuclear factor kappa B (RANK), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) genetic polymorphisms with persistent apical periodontitis (PAP) in Brazilian subjects. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.022DOI Listing

Indications for Extraction before Implant Therapy: Focus on Endodontic Status.

J Endod 2019 Mar 8. Epub 2019 Mar 8.

Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Introduction: The aim of the present study was to evaluate endodontic status and diagnosis of teeth before extraction and their impact on treatment planning and treatment outcomes of dental implant therapy.

Methods: Data were retrieved from patient files and radiographs of 596 Swedish individuals provided with implant therapy. Patients were categorized according to diagnosis in conjunction with tooth extraction as follows: PERIO (reason for extraction: periodontitis), CARIES (reason for extraction: caries, apical periodontitis, and/or root fracture), OTHER (reason for extraction: trauma and other), and MIX (a combination of these). Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.008DOI Listing
March 2019
1 Read

Dental Pulp Stem Cell Transplantation with 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside Accelerates Alveolar Bone Regeneration in Rats.

J Endod 2019 Apr 7;45(4):435-441. Epub 2019 Mar 7.

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Center for Tooth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei, Taiwan; Department of Dentistry, Wan-Fang Medical Center, Taipei Medical University, Taipei, Taiwan. Electronic address:

Introduction: Although the therapeutic potential of human dental pulp stem cells (hDPSCs) has been studied for bone regeneration, the therapeutic efficiency needs further consideration and examinations for clinical applications. Thus, the aims of this study were to evaluate the effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) on the osteogenic differentiation of hDPSCs and to examine the therapeutic efficiency of the THSG-enhanced osseous potential of hDPSCs in alveolar bony defects of rats.

Methods: Expressions of osteogenic messenger RNAs (including ALP, RUNX2, BGLAP, and AMBN) were examined by quantitative real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1016/j.joen.2018.12.019DOI Listing

Prevalence Studies on Root Canal Anatomy Using Cone-beam Computed Tomographic Imaging: A Systematic Review.

J Endod 2019 Apr 2;45(4):372-386.e4. Epub 2019 Mar 2.

Dental Specialty Center, Brazilian Military Police, Minas Gerais, Brazil.

Introduction: In the literature, several prevalence studies on root canal anatomy using cone-beam computed tomographic technology are currently available although their results remain disperse. This systematic review aimed to appraise and combine, under strict criteria conditions, selected prevalence studies in order to comprehend the distribution of root canal configuration types among different populations.

Methods: This systematic review was registered in PROSPERO. Read More

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http://dx.doi.org/10.1016/j.joen.2018.12.016DOI Listing

Regenerative Endodontic Procedures Posttrauma: Immunohistologic Analysis of a Retrospective Series of Failed Cases.

J Endod 2019 Apr 2;45(4):427-434. Epub 2019 Mar 2.

Department of Oral Health Sciences, Endodontology, Katholieke Universiteit Leuven, Leuven, Belgium; Biomaterials, BIOMAT, Leuven, Belgium.

Introduction: Regenerative endodontic procedures (REP) are a novel treatment modality to restore the function of necrotic pulp tissue via stimulation or transplantation of stem cells into the root canal. This study aimed to investigate the immunohistologic outcome of 3 extracted teeth because of sequelae of trauma and unsatisfactory REP outcomes.

Methods: Three immature permanent maxillary central incisors of 3 female patients (6-9 years) were extracted 5. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.007DOI Listing
April 2019
4 Reads

Machine-assisted Agitation Reduces Postoperative Pain during Root Canal Treatment: A Systematic Review and Meta-analysis from Randomized Clinical Trials.

J Endod 2019 Apr 2;45(4):387-393.e2. Epub 2019 Mar 2.

Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.

Introduction: This systematic review and meta-analysis aimed to assess whether machine-assisted agitation resulted in less postoperative pain (PP) compared with syringe irrigation with needle alone in adult patients undergoing root canal treatment.

Methods: A literature search was performed in 3 electronic databases for articles published before August 2018. Randomized clinical trials published in English that compared PP between machine-assisted agitation and syringe irrigation with needles as part of nonsurgical root canal treatment were included. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.013DOI Listing
April 2019
2 Reads

Management of Large Radicular Lesions Using Decompression: A Case Series and Review of the Literature.

J Endod 2019 Mar 1. Epub 2019 Mar 1.

Department of Endodontics, The Dental College of Georgia, Augusta University, Augusta, Georgia. Electronic address:

The purpose of this study was to report the clinical efficacy of decompression for 3 cases with large periapical lesions and to review technique details. Three cases with large periapical cystic lesions were treated with decompression after root canal treatment. A traditional decompression technique was used for the first case. Read More

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http://dx.doi.org/10.1016/j.joen.2018.12.014DOI Listing
March 2019
2 Reads

Radicular Groove Accessory Canal Morphology in Mandibular First Premolars: Micro-computed Tomographic Study.

J Endod 2019 Feb 28. Epub 2019 Feb 28.

Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.

Introduction: The purpose of this study was to investigate the morphologic features of radicular groove accessory canals (RGACs) in mandibular first premolars and their relationship to root anatomy by micro-computed tomographic imaging.

Methods: A total of 154 single-rooted mandibular first premolars with radicular grooves were selected. The teeth were scanned by micro-computed tomographic imaging, and the following parameters were recorded: (1) the presence of RGACs, (2) the origin of RGACs, (3) the position of the RGAC foramen in the groove in relation to root length, (4) the foramen diameter, (5) the type of groove present according to the Arizona State University dental anthropology scoring system (ASUDAS), and (6) the type of anatomy present according to Vertucci's classification. Read More

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http://dx.doi.org/10.1016/j.joen.2018.12.017DOI Listing
February 2019

Nonsurgical Endodontic Treatment of Necrotic Teeth Resolved Apical Lesions on Adjacent Implants with Retrograde/Apical Peri-implantitis: A Case Series with 2-year Follow-up.

J Endod 2019 Feb 28. Epub 2019 Feb 28.

Department of Periodontics and Dental Hygiene, School of Dentistry, University of Texas Health Science Center at Houston, Houston, Texas.

Retrograde (or apical/periapical) peri-implantitis (RPI) presents with radiographic signs of bone loss at the periapical area of endosteal implants and may also present with clinical signs of abscess formation or a sinus tract traceable to the implant periapex. The lesion may form days up to several years after the initial implant placement. In contrast to marginal peri-implantitis, which has a prevalence of 19. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.002DOI Listing
February 2019
1 Read

Effect of Different Concentrations of Sodium Hypochlorite on Outcome of Primary Root Canal Treatment: A Randomized Controlled Trial.

J Endod 2019 Apr 1;45(4):357-363. Epub 2019 Mar 1.

Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.

Introduction: The aim of this study was to evaluate the effect of 2 different concentrations of sodium hypochlorite on healing and postoperative pain after primary endodontic treatment.

Methods: One hundred mandibular molars with pulp necrosis and chronic apical periodontitis were randomly assigned to 2 treatment groups: high-concentration (HC) 5% sodium hypochlorite and low-concentration (LC) 1% sodium hypochlorite. Root canal treatment was performed using a standardized protocol. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.003DOI Listing

Stress Analyses of Retrograde Cavity Preparation Designs for Surgical Endodontics in the Mesial Root of the Mandibular Molar: A Finite Element Analysis-Part I.

J Endod 2019 Apr 1;45(4):442-446. Epub 2019 Mar 1.

Microscope Center, Department of Conservative Dentistry and Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Korea; Department of Electrical & Electronic Engineering, Yonsei University College of Engineering, Seoul, Korea. Electronic address:

Introduction: The aim of this study was to investigate the influence of various apical preparation designs for surgical endodontics on stress concentrations in the mesial root of the mandibular molar under different experimental conditions using finite element analysis.

Methods: We designed 2 apical preparation groups according to whether an isthmus was present or not. Each group contained 4 subgroups according to the size of the apical preparation. Read More

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http://dx.doi.org/10.1016/j.joen.2019.01.001DOI Listing
April 2019
2 Reads

Effect of Root Canal Preparation Techniques on Crack Formation in Root Dentin.

J Endod 2019 Apr 1;45(4):447-452. Epub 2019 Mar 1.

Endodontic Division, School of Dentistry, University of Maryland, Baltimore, Maryland.

Introduction: The aim of this study was to assess the frequency of root crack formation caused by the use of manual instrumentation, 2 rotary systems, and 1 reciprocating system using light-emitting diode transillumination.

Methods: One hundred fifty mandibular premolars were randomly divided into 5 groups (n = 30): control 1, no intervention; control 2, instrumented with hand files; group 3, instrumented with ProTaper Universal rotary files (Dentsply Maillefer, Ballaigues, Switzerland); group 4, instrumented with OneShape rotary files (Micro-Mega, Besancon, France); and group 5: instrumented with the WaveOne reciprocal system (Dentsply Maillefer, Ballaigues, Switzerland). After root canal preparations, the roots were sectioned at 3, 6, and 9 mm from the apex with water irrigation. Read More

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http://dx.doi.org/10.1016/j.joen.2018.12.018DOI Listing
April 2019
2 Reads

A 10-year Follow-up Study of 119 Teeth Treated with Apical Surgery and Root-end Filling with Mineral Trioxide Aggregate.

J Endod 2019 Apr 1;45(4):394-401. Epub 2019 Mar 1.

Oral and Maxillofacial Radiology, Applied Oral Sciences, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Sai Ying Pun, Hong Kong SAR, China.

Introduction: The objective of this clinical study was to assess the long-term outcome (clinical signs/symptoms and radiographic healing) of teeth treated with apical surgery and mineral trioxide aggregate (MTA) for root-end filling.

Methods: One hundred ninety-five patients were recalled 1, 5, and 10 years after apical surgery for clinical and radiographic examinations. Three calibrated observers evaluated the periapical radiographs independently. Read More

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http://dx.doi.org/10.1016/j.joen.2018.12.015DOI Listing
April 2019
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Effects of Restorative Materials on Dental Pulp Stem Cell Properties.

J Endod 2019 Apr 25;45(4):420-426. Epub 2019 Feb 25.

Institute of Oral Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Stomatology, National Cheng Kung University Hospital, Tainan, Taiwan. Electronic address:

Introduction: Dental pulp stem cells (DPSCs) are multipotent progenitors for biotechnological practices, but the influences of existing restorations on their viability and differentiation are not well-known. This study was aimed to investigate in vivo and in vitro responses of DPSCs to restorative materials.

Methods: Class I cavities were prepared on molars scheduled to be extracted and then restored with a resin-based composite (RBC), a glass ionomer cement, or zinc oxide eugenol. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.021DOI Listing

Multiple Cervical Root Resorption in a Young Adult Female Previously Treated with Chemotherapy: A Case Report.

J Endod 2019 Mar;45(3):349-353

University of Barcelona, Barcelona, Spain; IDIBELL Institute, Barcelona, Spain.

Multiple idiopathic cervical root resorption is an aggressive form of external root resorption that occurs at the cementoenamel junction and can affect multiple teeth (a minimum of 3) throughout the entire dentition. Most of the individuals affected are healthy with noncontributory medical histories. The resorption is usually detected as an incidental finding on radiographs or during dental examination. Read More

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http://dx.doi.org/10.1016/j.joen.2018.12.012DOI Listing
March 2019
1 Read