7,760 results match your criteria Journal of Endodontics [Journal]


Radiographic Indications of Vertucci Type V Configuration in the Distal Root of Mandibular Molars: A Case Series.

J Endod 2019 Feb 12. Epub 2019 Feb 12.

Department of Endodontics, School of Dentistry, the University of Texas Health Science Center at Houston, Houston, Texas.

Knowledge of the prevalent root canal anatomy and potential variations is necessary before the initiation of endodontic treatment. The purpose of this study was to aid in the detection and treatment of the Vertucci type V canal configuration when present in the distal root of the mandibular molars. This case series presents 3 radiographic indications of a type V configuration in the distal roots of the mandibular molars as revealed on conventional periapical radiographs: a "ghost" apex, a fast break canal, and eccentric canal tracing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00992399183084
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http://dx.doi.org/10.1016/j.joen.2018.12.010DOI Listing
February 2019
1 Read

Periapical Microsurgery: A 4-dimensional Analysis of Healing Patterns.

J Endod 2019 Feb 12. Epub 2019 Feb 12.

Department of Endodontics, University of North Carolina School of Dentistry, Chapel Hill, North Carolina. Electronic address:

Introduction: Currently, the success of periapical microsurgery is determined by the restoration of the lamina dura and the elimination of symptoms. However, inadequate site preservation may prevent later implant placement. Although not possible before, the advent of cone-beam computed tomographic imaging and computer-aided registration allows for indirect and accurate 3-dimensional analysis of the surgical site over time. Read More

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http://dx.doi.org/10.1016/j.joen.2018.11.002DOI Listing
February 2019

The Impact of Different Diagnostic Imaging Modalities on the Evaluation of Root Canal Anatomy and Endodontic Residents' Stress Levels: A Clinical Study.

J Endod 2019 Feb 12. Epub 2019 Feb 12.

Department of Endodontology, King's College London Dental Institute, London, UK.

Introduction: The purpose of this study was firstly to compare the impact of radiographs, cone-beam computed tomographic (CBCT) imaging, and 3D Endo software (Dentsply Sirona, Ballaigues, Switzerland) on the assessment of root canal anatomy and radiographic quality of endodontic treatment and secondly to assess stress levels in the same cohort of residents performing endodontic treatment.

Methods: Sixty patients requiring primary molar endodontic treatment were allocated randomly into 3 groups: group 1 (n = 20), conventional radiographs (periapical radiography [PR]) only; group 2 (n = 20), PR and CBCT imaging; and group 3 (n = 20), PR, CBCT imaging, and 3D Endo software. All treatment was performed using a standardized protocol. Read More

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http://dx.doi.org/10.1016/j.joen.2018.12.001DOI Listing
February 2019

Efficacy and Safety of Oral Premedication on Pain after Nonsurgical Root Canal Treatment: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.

J Endod 2019 Feb 5. Epub 2019 Feb 5.

Department of Restorative Sciences/Endodontics, Texas A&M University College of Dentistry, Dallas, Texas.

Introduction: This review aimed to find the most effective oral premedication in reducing pain in adults after nonsurgical root canal therapy (NSRCT) using network meta-analysis.

Methods: The review protocol was registered in the PROSPERO database (CRD42017071899). A literature search was performed in the MEDLINE and EBSCOhost databases until June 2017 with no language restriction. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.016DOI Listing
February 2019

Healing Capacity of Autologous Bone Marrow-derived Mesenchymal Stem Cells on Partially Pulpotomized Dogs' Teeth.

J Endod 2019 Feb 2. Epub 2019 Feb 2.

Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt; Department of Oral Biology, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Gamasa, Mansoura, Egypt.

Introduction: Partial pulpotomy is a vital treatment for carious and traumatic exposure, especially in young permanent teeth. Cell-based therapy for partially pulpotomized teeth can be considered a promising approach for dentin-pulp complex regeneration. This study evaluated the healing capacity of autologous bone marrow-derived stem cells (BMSCs) on partially pulpotomized teeth in a dog model. Read More

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http://dx.doi.org/10.1016/j.joen.2018.11.013DOI Listing
February 2019
3 Reads

A Retrospective Comparison of Outcome in Patients Who Received Both Nonsurgical Root Canal Treatment and Single-tooth Implants.

J Endod 2019 Feb;45(2):99-103

School of Dentistry, Loma Linda University School of Dentistry, Loma Linda, California.

Introduction: Currently, no study has compared the outcome of nonsurgical root canal treatment (NSRCT) and single-tooth implants (STIs) provided to the same patient. The purpose of this study was to determine if the survival outcome of the 2 treatment modalities is different.

Methods: The medical/dental records of 3671 patients with at least 1 STI and 1 NSRCT were reviewed. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.018DOI Listing
February 2019

Ibuprofen and Acetaminophen Versus Intranasal Ketorolac (Sprix) in an Untreated Endodontic Pain Model: A Randomized, Double-blind Investigation.

J Endod 2019 Feb;45(2):94-98

Division of Biosciences, The Ohio State University, Columbus, Ohio.

Introduction: Previously, ketorolac was available for primary use only via intravenous and intramuscular routes. Its availability in intranasal form offers an alternative route of administration that patients can self-administer. The purpose of this study was to compare the efficacy of intranasal ketorolac (Sprix; Egalet US Inc, Wayne, PA) with a combination of ibuprofen/acetaminophen in an acute pain model of untreated endodontic patients experiencing moderate to severe pain and symptomatic apical periodontitis. Read More

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http://dx.doi.org/10.1016/j.joen.2018.11.005DOI Listing
February 2019

Aluminum Chloride versus Electrocauterization in Periapical Surgery: A Randomized Controlled Trial.

J Endod 2019 Feb;45(2):89-93

Stomatology Department, Faculty of Medicine and Dentistry, University of Valencia, Valencia, Spain.

Introduction: The aim of this study was to evaluate the efficacy of 2 hemostatic agents in periapical surgery and its relationship with patient- and tooth-dependent variables.

Methods: A prospective study was designed with 2 randomized parallel groups established according to the hemostatic agent used: aluminum chloride or electrocauterization. The surgeon and 2 independent blinded observers examined the initial and final bleeding and recorded it as 0 (no hemorrhage control), 1 (slight but apparent intermittent bleeding), or 2 (complete hemorrhage control). Read More

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http://dx.doi.org/10.1016/j.joen.2018.11.004DOI Listing
February 2019

Case Reports in Maxillary Posterior Teeth by Guided Endodontic Access.

J Endod 2019 Feb;45(2):214-218

Department of Operative Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

The localization of partial or completed root canal obliteration is a challenging task in endodontic practice. Recently, guided endodontics has become an alternative solution for those cases. Although this technique has already been used clinically in managing anterior teeth, in this report, we describe 3 complex clinical scenarios of calcified root canals of 1 molar and 2 premolars using guided endodontics. Read More

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http://dx.doi.org/10.1016/j.joen.2018.11.008DOI Listing
February 2019

Assessment of Cone-beam Computed Tomographic Artifacts from Different Intracanal Materials on Birooted Teeth.

J Endod 2019 Feb;45(2):209-213.e2

Department of Dentistry, State University of Paraíba, Campina Grande, Paraiba, Brazil. Electronic address:

Introduction: This study quantitatively evaluated the type and amount of image artifacts generated by different intracanal materials in birooted teeth scanned at different exposure parameters.

Methods: The sample consisted of 15 birooted premolars. Seven different intracanal material combinations were used in each tooth one at a time: (1) roots without intracanal materials, (2) roots with gutta-percha, (3) a buccal root with gutta-percha and a lingual root with a fiberglass post, (4) a buccal root with gutta-percha and a lingual root with a metal core fiberglass post, (5) buccal and lingual roots with fiberglass posts, (6) buccal and lingual roots with metal core fiberglass posts, and (7) buccal and lingual roots with NiCr metal posts. Read More

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http://dx.doi.org/10.1016/j.joen.2018.11.007DOI Listing
February 2019

Effect of Temperature of Sodium Hypochlorite on Cyclic Fatigue Resistance of Heat-treated Reciprocating Files.

J Endod 2019 Feb;45(2):205-208

Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.

Introduction: The aim of this study was to evaluate the effect of different temperatures of sodium hypochlorite (NaOCl) on the cyclic fatigue resistance of the heat-treated file systems.

Methods: The cyclic fatigue resistance of Reciproc 25 (VDW Dental, Munich, Germany), Reciproc Blue R25 (VDW), WaveOne Primary (Dentsply Maillefer, Ballaigues, Switzerland), WaveOne Gold Primary (Dentsply Maillefer), and One Shape (25.06; Micro Mega, Besançon, France) was tested in the following conditions: control (no immersion), immersion in distilled water (DW) at 37°C ± 1°C, immersion in DW at 60°C ± 1°C, immersion in NaOCl at 37°C ± 1°C, and immersion in NaOCl at 60°C ± 1°C. Read More

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http://dx.doi.org/10.1016/j.joen.2018.11.003DOI Listing
February 2019

Mechanical Properties of Various Glide Path Preparation Nickel-titanium Rotary Instruments.

J Endod 2019 Feb;45(2):199-204

Department of Conservative Dentistry, School of Dentistry, Dental Research Institute, Pusan National University, Yangsan, Korea. Electronic address:

Introduction: The aim of this study was to compare the cyclic fatigue, torsional resistance, and bending stiffness of single-file glide path preparation nickel-titanium instruments.

Methods: ProGlider (#16/progressive taper; Dentsply Sirona, Ballaigues, Switzerland), One G (#14/.03; Micro-Mega, Besancon, France), and EdgeGlidePath (#16/progressive taper; Edge Endo, Albuquerque, NM) were tested. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.017DOI Listing
February 2019
1 Read

Performance of Reciproc Blue R25 Instruments in Shaping the Canal Space without Glide Path.

J Endod 2019 Feb;45(2):194-198

Department of Endodontics, Grande Rio University, Duque de Caxias, Rio de Janeiro, Brazil.

Introduction: This study assessed the frequency in which Reciproc Blue R25 instruments (VDW, Munich, Germany) reached the full working length (WL) of mandibular molar canals without a glide path. The influence of the type of electric motor (ie, conventional corded or cordless) on the instrument's performance was also assessed.

Methods: One hundred mandibular molars with slight to moderate root canals were selected and randomly assigned into 1 of 2 experimental groups according to the type of electric motor used: conventional corded (VDW Silver, VDW) or cordless motors (VDW. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.011DOI Listing
February 2019

Contribution of Root Canal Treatment to the Fracture Resistance of Dentin.

J Endod 2019 Feb;45(2):189-193

Department of Materials Science and Engineering, University of Washington, Seattle, Washington; Department of Restorative Dentistry, University of Washington, Seattle, Washington; Department of Oral Health Science, School of Dentistry, University of Washington, Seattle, Washington. Electronic address:

Introduction: Although the strength and toughness of dentin decrease with age, no study has explored if restorative treatments are a contributing factor.

Methods: Multiple extracted teeth were obtained from randomly selected donors and categorized according to donor age and prior root canal treatment. The microstructure and chemical composition of radicular dentin were evaluated using scanning electron microscopy and Raman spectroscopy, respectively, and the strength was evaluated in 4-point flexure to failure. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.004DOI Listing
February 2019

Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice.

J Endod 2019 Feb;45(2):181-188

Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts; Department of Endodontics, Boston University Goldman School of Dental Medicine, Boston, Massachusetts.

Introduction: In general, mice develop chronic and nonhealing periapical lesions after endodontic infection. Surprisingly, we recently found that toll-like receptor 2 (TLR2)/interleukin 10 (IL-10) double-knockout (dKO) mice exhibited acute but resolving osteomyelitislike inflammation. In this study, we examined the kinetics of endodontic infection-induced inflammation in TLR2/IL-10 dKO mice and explored a potential mechanism of periapical wound healing mediated by the hypoxia-inducible factor 1 alpha (HIF-1α) subunit and arginase 1. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364571PMC
February 2019
1 Read

Cross Talk between Apical Periodontitis and Metabolic Disorders: Experimental Evidence on the Role of Intestinal Adipokines and Akkermansia muciniphila.

J Endod 2019 Feb;45(2):174-180

Programa de Pós-Graduação em Odontologia, Escola de Ciências da Saúde, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil; Centro de Pesquisa em Toxicologia e Farmacologia, Escola de Ciências da Saúde, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências, PUCRS, Porto Alegre, Rio Grande do Sul, Brazil; Laboratório de Patologia Bucal, Escola de Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

Introduction: Infection and dysbiosis present a close relationship with metabolic diseases although the influence of apical periodontitis (AP) in this context needs further investigation. This study evaluated the influence of AP in a rat model of metabolic syndrome induced by 10% fructose supplementation.

Methods: Male Wistar rats were used. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.013DOI Listing
February 2019
1 Read

Inhibition of Nuclear Factor Kappa B Prevents the Development of Experimental Periapical Lesions.

J Endod 2019 Feb;45(2):168-173

Department of Pulp Biology and Endodontics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Introduction: Nuclear factor kappa B (NF-κB) is an important transcriptional regulator of angiogenesis involving B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) signaling pathways. Thus, inhibition of NF-κB may suppress the development of periapical lesions via blockage of angiogenesis. Accordingly, we examined the effects of NF-κB decoy oligodeoxynucleotide (ODN) treatment on experimentally induced periapical lesions. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367709PMC
February 2019
1 Read

The Effects of Mitogen-activated Protein Kinase Signaling Pathways on Lipopolysaccharide-mediated Osteo/Odontogenic Differentiation of Stem Cells from the Apical Papilla.

J Endod 2019 Feb;45(2):161-167

VIP Center, School and Hospital of Stomatology, Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China. Electronic address:

Introduction: Odontogenic differentiation of human stem cells from the apical papilla (SCAPs) is a prerequisite step in the root development of immature permanent teeth. However, little is known about the effects of an inflammatory environment on osteo/odontogenic differentiation of SCAPs. The purpose of this study was to investigate the effects of lipopolysaccharide (LPS) on the proliferation and osteo/odontogenic differentiation of SCAPs and the role of mitogen-activated protein kinase (MAPK) signaling pathways in LPS-mediated osteo/odontogenic differentiation of SCAPs. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.009DOI Listing
February 2019

Direct and Indirect Effect of Chlorhexidine on Survival of Stem Cells from the Apical Papilla and Its Neutralization.

J Endod 2019 Feb;45(2):156-160

Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas. Electronic address:

Introduction: Several irrigants have been used for disinfection in regenerative endodontic procedures including chlorhexidine (CHX). In this context, the antibacterial properties of disinfectants are mainly in focus of research even though they may have an undesirable impact on the fate of stem cells. In this study, we hypothesized that CHX has both a direct effect when applied to stem cells of the apical papilla (SCAPs) and an indirect effect when SCAPs are exposed to dentin previously conditioned with CHX. Read More

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http://dx.doi.org/10.1016/j.joen.2018.11.012DOI Listing
February 2019

Cyclic Adenosine Monophosphate Promotes Odonto/Osteogenic Differentiation of Stem Cells from the Apical Papilla via Suppression of Transforming Growth Factor Beta 1 Signaling.

J Endod 2019 Feb;45(2):150-155

Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.

Introduction: Stem cells from the apical papilla (SCAPs) possess strong odonto/osteogenic differentiation potential. This study investigated the effect of cyclic adenosine monophosphate (cAMP) on odonto/osteogenic differentiation of SCAPs and the underlining interplay between cAMP and transforming growth factor beta 1 (TGF-β1).

Methods: SCAPs were stimulated with an activator of cAMP (forskolin) in the presence of either TGF-β1 or a TGF-β1 inhibitor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00992399183069
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http://dx.doi.org/10.1016/j.joen.2018.10.008DOI Listing
February 2019
1 Read

Personalized Cell Therapy for Pulpitis Using Autologous Dental Pulp Stem Cells and Leukocyte Platelet-rich Fibrin: A Case Report.

J Endod 2019 Feb;45(2):144-149

Centro de Investigación en Biología y Regeneración Oral, Faculty of Dentistry, Universidad de Los Andes, Santiago, Chile. Electronic address:

Introduction: Regenerative endodontic procedures have emerged as a new treatment. The aim of this case report was to describe a regenerative autologous cellular therapy using mesenchymal stem cells from inflamed dental pulp and leukocyte platelet-rich fibrin (L-PRF) in a mature tooth.

Methods: A healthy 50-year-old man consulting for spontaneous dental pain was referred for endodontic treatment in tooth #28, which was diagnosed with symptomatic irreversible pulpitis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00992399183079
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http://dx.doi.org/10.1016/j.joen.2018.11.009DOI Listing
February 2019
1 Read

Clinical, Radiographic, and Histologic Outcome of Regenerative Endodontic Treatment in Human Teeth Using a Novel Collagen-hydroxyapatite Scaffold.

J Endod 2019 Feb;45(2):136-143

Torabinejad Institute of Surgical Education and Research Venues, Irvine, California.

Introduction: Histologic examination of teeth after regenerative endodontic treatment (RET) shows that the type, quality, and quantity of tissues formed in the root canal space are not predictable. The aim of this study was to examine clinically, radiographically, and histologically the outcome of RET in immature noninfected human teeth using SynOss Putty (Collagen Matrix Inc, Oakland, NJ) as a scaffold.

Methods: Three pairs of maxillary/mandibular first premolars in 3 patients scheduled for extraction were included. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.012DOI Listing
February 2019
3.375 Impact Factor

Interradicular Root Canals in Mandibular First Molars: A Literature Review and Ex Vivo Study.

J Endod 2019 Feb;45(2):129-135

Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Bern, Switzerland; Department of Operative Dentistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address:

Introduction: Successful endodontic treatment vastly depends to a high degree on an accurate knowledge of root canal system morphology. It is a prerequisite to be aware of all possible reservoirs where bacteria and/or toxins can persist, compromising the surrounding tissues; such knowledge results in endodontic success.

Methods: The presence of interradicular canals and diverticula between the pulp chamber floor and the bifurcation area surface of 117 mandibular first molars was investigated. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.019DOI Listing
February 2019

Periapical Healing in Single-visit Endodontics under General Anesthesia in Special Needs Patients.

J Endod 2019 Feb;45(2):116-122

Special Care Clinic, Seoul National University Dental Hospital, Seoul, Korea. Electronic address:

Introduction: The aim of this study was to determine the prognostic factors of periapical healing of teeth after single-visit nonsurgical endodontic treatment under general anesthesia in special needs patients.

Methods: This retrospective study collected 448 teeth from 241 patients (mean age = 27.4 years, standard deviation = 13. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.020DOI Listing
February 2019

Elevated Systemic Inflammatory Burden and Cardiovascular Risk in Young Adults with Endodontic Apical Lesions.

J Endod 2019 Feb;45(2):111-115

Laboratory of Periodontal Biology, Department of Conservative Dentistry, Faculty of Dentistry, Universidad de Chile, Santiago, Chile; Dentistry Unit, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago, Chile. Electronic address:

Introduction: The aim of this study was to assess whether apical lesions are associated with inflammatory serum markers of cardiovascular risk, especially high-sensitivity C-reactive protein (hsCRP), in young adults.

Methods: In this cross-sectional study, otherwise healthy individuals with apical lesions of endodontic origin (ALEOs) and a clinical diagnosis of asymptomatic apical periodontitis and controls aged between 18 and 40 years were included. Patients' sociodemographic characteristics, medical history, and classic cardiovascular risk factors were recorded, and the pathobiological determinants of atherosclerosis in youth score was calculated. Read More

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http://dx.doi.org/10.1016/j.joen.2018.11.014DOI Listing
February 2019

Investigating Potential Correlations between Endodontic Pathology and Cardiovascular Diseases Using Epidemiological and Genetic Approaches.

J Endod 2019 Feb 17;45(2):104-110. Epub 2019 Jan 17.

Department of Endodontics, University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas; Center for Craniofacial Research, University of Texas Health Science Center School of Dentistry at Houston, Houston, Texas; Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas. Electronic address:

Introduction: Apical periodontitis (AP) and cardiovascular diseases (CVDs) are chronic conditions triggered by an inflammatory process and sharing similar pathogeneses and molecular players. Previous studies have suggested that AP may perpetuate a systemic inflammation state and, in turn, contribute to CVD. In this study, we investigated the potential association between endodontic pathology and CVD using epidemiological and genetic approaches. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00992399183074
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http://dx.doi.org/10.1016/j.joen.2018.10.014DOI Listing
February 2019
7 Reads

Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines.

J Endod 2019 Feb 21;45(2):123-128. Epub 2018 Dec 21.

Department of Biology and Human Genetics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.

Introduction: The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin [IL]-1β, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG) ratios and determine their potential correlation.

Methods: The study group consisted of 50 periapical lesions collected in conjunction with apicoectomy. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.015DOI Listing
February 2019
1 Read
3.375 Impact Factor

Anti-inflammatory and Osteogenic Effects of Calcium Silicate-based Root Canal Sealers.

J Endod 2019 Jan;45(1):73-78

Department of Conservative Dentistry, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju, Korea. Electronic address:

Introduction: An ideal root canal sealer creates a bacteria-resistant seal and exhibits antimicrobial activity, biocompatibility, and osteoconductivity. The aim of this study was to assess the effects of 3 root canal sealers on cell viability, inflammatory response, and osteogenic potential in MC3T3-E1 cells.

Methods: AH Plus (Dentsply Caulk, Milford, DE), MTA Fillapex (Angelus Solucxoes Odontologicas, Londrina, Brazil), and EndoSequence BC (Brasseler, Savannah, GA) were mixed according to the manufacturer's instructions, and samples were prepared as extraction media (final dilution: 1/10). Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.006DOI Listing
January 2019
1 Read

Effect of Different Speeds of Up-and-down Motion on Canal Centering Ability and Vertical Force and Torque Generation of Nickel-titanium Rotary Instruments.

J Endod 2019 Jan;45(1):68-72.e1

Department of Pulp Biology and Endodontics, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Introduction: This study was performed to evaluate how the speed of up-and-down motion affects the canal centering ability and torque/force generation of ProTaper Next rotary instruments (Dentsply Maillefer, Ballaigues, Switzerland).

Methods: Twenty-one simulated resin canal blocks with a J-shaped canal were prepared with ProTaper Next X1, X2, and X3 instruments using an original automated root canal instrumentation and torque/force analyzing device with up-and-down speed settings of 10, 50, and 100 mm/min (low-, medium-, and high-speed groups, respectively). Pre- and postinstrumentation images were superimposed, and centering ratios were calculated at 0-3 mm from the apex. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.002DOI Listing
January 2019
2 Reads
3.375 Impact Factor

Comparative Biocompatibility and Osteogenic Potential of Two Bioceramic Sealers.

J Endod 2019 Jan;45(1):51-56

Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas. Electronic address:

Introduction: Endodontic sealers have traditionally been used to seal dentinal tubules, creating a homogenous interface between the obturation material and the dentinal walls. However, bioceramic sealers have potential added benefits because of their bioactivity. After adequate endodontic therapy, osseous healing is largely dependent on the differentiation and activity of osteoblasts. Read More

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http://dx.doi.org/10.1016/j.joen.2018.08.007DOI Listing
January 2019
7 Reads

Ultrasonic Irrigant Activation during Root Canal Treatment: A Systematic Review.

J Endod 2019 Jan;45(1):31-44.e13

Department of Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address:

Introduction: The aim of this study was to systematically review the evidence on the cleaning and disinfection of root canals and the healing of apical periodontitis when ultrasonic irrigant activation is applied during primary root canal treatment of mature permanent teeth compared with syringe irrigation.

Methods: An electronic search was conducted of the Cochrane Library, Embase, LILACS, PubMed, SciELO, and Scopus databases using both free-text key words and controlled vocabulary. Additional studies were sought through hand searching of endodontic journals and textbooks. Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.010DOI Listing
January 2019
4 Reads

Efficacy of Articaine Versus Lidocaine Administered as Supplementary Intraligamentary Injection after a Failed Inferior Alveolar Nerve Block: A Randomized Double-blind Study.

J Endod 2019 Jan 6;45(1):1-5. Epub 2018 Dec 6.

Department of Conservative Dentistry and Endodontics, Faculty of Dentistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.

Introduction: The present study comparatively evaluated the anesthetic efficacy of 4% articaine versus 2% lidocaine given as supplemental intraligamentary injections after a failed inferior alveolar nerve block.

Methods: One hundred six adult patients with symptomatic irreversible pulpitis in a mandibular first or second molar received an initial inferior alveolar nerve block with 2% lidocaine with 1:80,000 epinephrine. Pain during the endodontic treatment was assessed using the Heft-Parker visual analog scale. Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.012DOI Listing
January 2019
2 Reads

Outcome of Crown and Root Resection: A Systematic Review and Meta-analysis of the Literature.

J Endod 2019 Jan 6;45(1):6-19. Epub 2018 Dec 6.

Department of Endodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Introduction: A systematic review and meta-analysis were conducted to report combined and individual weighted pooled outcome rates for crown resection (CR) and root resection (RR) procedures.

Methods: Three electronic databases (PubMed [MEDLINE], Scopus, and the Cochrane Library) were searched to identify human studies in 12 languages on CR (hemisection, trisection, and premolarization) and RR (amputations and RRs without removal of crown portions). Five peer-reviewed journals, references of relevant publications, and reviews were hand searched. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.003DOI Listing
January 2019
1 Read

Influence of Different Angles of File Access on Cyclic Fatigue Resistance of Reciproc and Reciproc Blue Instruments.

J Endod 2018 Dec 25;44(12):1849-1855. Epub 2018 Oct 25.

Department of Conservative Dentistry, School of Dentistry, Pusan National University, Yangsan, Korea. Electronic address:

Introduction: The purpose of this study was to compare the cyclic fatigue of Reciproc (REC; VDW, Munich, Germany) and Reciproc blue (REB, VDW) with different angles of file access.

Methods: The cyclic fatigue resistance of 120 new REC R25 and REB R25 (REB) files was tested. Instruments were divided into 8 groups on the basis of the access angle inside the artificial canal tested (n = 15): groups 1, 2, 3, and 4 included REC tested at 0°, 10°, 20°, and 30°, respectively, and groups 5, 6, 7, and 8 consisted of REB tested at 0°, 10°, 20°, and 30°, respectively. Read More

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http://dx.doi.org/10.1016/j.joen.2018.08.012DOI Listing
December 2018
1 Read

Revascularization-associated Intracanal Calcification: A Case Report with an 8-year Review.

J Endod 2018 Dec 25;44(12):1792-1795. Epub 2018 Oct 25.

Department of Endodontics, New York University College of Dentistry, New York, New York.

Revascularization-associated intracanal calcification (RAIC) is a common finding in immature teeth managed with regenerative endodontic treatment (RET). The aim of this report was to illustrate a case in which 2 mandibular premolar teeth developed complete canal obliteration and have been reviewed for 8 years. The 3 primary outcome goals as defined by the American Association of Endodontists after RET are resolution of signs and symptoms of pulp necrosis, further root maturation, and achievement of responses to pulp vitality testing. Read More

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http://dx.doi.org/10.1016/j.joen.2018.08.009DOI Listing
December 2018
9 Reads

Retraction Notice.

Authors:

J Endod 2018 12;44(12):1888

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http://dx.doi.org/10.1016/j.joen.2018.10.005DOI Listing
December 2018
2 Reads

Virtual Simulation of Autotransplantation Using 3-dimensional Printing Prototyping Model and Computer-assisted Design Program.

J Endod 2018 Dec;44(12):1883-1888

Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea. Electronic address:

This case report describes an innovative virtual simulation method using a computer-aided rapid prototyping (CARP) model and a computer-aided design (CAD) program for autotransplantation of an immature third molar.A compromised left mandibular second molar (#18) was extracted and replaced by autotransplantation using an immature left mandibular third molar (#17). In order to minimize the surgical time and injury to the donor tooth, a virtual 3-dimensional (3D) rehearsal surgery was planned. Read More

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December 2018
2 Reads
3.375 Impact Factor

Comparison between Single-file Rotary Systems: Part 2-The Effect of Length of the Instrument Subjected to Cyclic Loading on Cyclic Fatigue Resistance.

J Endod 2018 Dec;44(12):1837-1842

Division of Endodontics, School of Dental Medicine, University at Buffalo, Buffalo, New York.

Introduction: The aim of this study was to compare the cyclic fatigue resistance of XP Shaper (XP), HyFlex EDM One File (EDM), and WaveOne Gold Primary (WOG) when operated according to their manufacturers' recommendations at different lengths and to investigate the cyclic fatigue limit of XP Shaper when operated at 3000 rpm.

Methods: One hundred fifty instruments from 4 different rotary systems (F2 Protaper Universal [PTU], WOG, EDM, and XP) were tested for their cyclic fatigue resistance in a simulated 90° curved canal at a 37°C water bath temperature at 3 different working lengths (15 mm, 17 mm, and 19 mm). The time taken for instruments to fracture was recorded, and the number of cycles to failure was calculated. Read More

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http://dx.doi.org/10.1016/j.joen.2018.07.021DOI Listing
December 2018
6 Reads

Pentraxin 3 Modulates the Inflammatory Response in Human Dental Pulp Cells.

J Endod 2018 Dec;44(12):1826-1831

Department of Oral Physiology, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan, South Korea. Electronic address:

Introduction: Pentraxin 3 (PTX3) has been suggested as a novel inflammatory biomarker in inflammation-associated diseases. The aim of this study was to examine the role of PTX3 in the inflammatory response of human dental pulp cells (HDPCs).

Methods: HDPCs were treated with tumor necrosis factor alpha (TNF-α), and total RNA and protein were extracted. Read More

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http://dx.doi.org/10.1016/j.joen.2018.08.003DOI Listing
December 2018
7 Reads

Influence of the Vehicle and Antibiotic Formulation on Cytotoxicity of Triple Antibiotic Paste.

J Endod 2018 Dec;44(12):1812-1816

Department of Restorative Dentistry, Araraquara School of Dentistry, São Paulo State University-UNESP, Araraquara, São Paulo, Brazil.

Introduction: The aim of this study was to assess the influence of antibiotic formulations (tablet/capsule [TC] or United States Pharmacopeia [USP]-grade antibiotics) and vehicles (water [HO] or macrogol + propylene glycol [MP]) on the cytotoxicity and pH of triple antibiotic pastes (TAPs).

Methods: L929 fibroblasts were exposed to TAPs prepared with TC or USP-grade antibiotics mixed with HO or MP for 72 hours. Each isolated antibiotic with each vehicle, each isolated vehicle, and the culture medium were used as controls. Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.009DOI Listing
December 2018
8 Reads

Comprehensive Characterization of 2 Immature Teeth Treated with Regenerative Endodontic Procedures.

J Endod 2018 Dec;44(12):1802-1811

Department of Endodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas. Electronic address:

Introduction: Regeneration of the pulp-dentin complex is the penultimate goal of regenerative endodontic procedures (REPs). Histological outcomes have demonstrated reparative tissue formation in human teeth extracted post-REPs. However, lack of accurate characterization has precluded identification of the true nature of tissues formed post-REP. Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.007DOI Listing
December 2018
2 Reads

Effect of Residual Dental Pulp Tissue on Regeneration of Dentin-pulp Complex: An In Vivo Investigation.

J Endod 2018 Dec;44(12):1796-1801

Private practice, Redlands, California.

Introduction: Current pulp revascularization procedures in teeth with necrotic pulps and open apices have produced histologic evidence of connective tissue growth, cementum, and bone within the root canals of experimental animals. This study aims to investigate the effect of maintaining uninflamed residual apical pulp tissue on the histologic outcome of pulp-dentin complex regeneration after a revascularization procedure in immature ferret cuspid teeth.

Methods: Twenty-eight cuspid teeth from 7 young male ferrets were used in this experiment. Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.005DOI Listing
December 2018
3 Reads

Immunohistochemical Analysis of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha in Periapical Lesions.

J Endod 2018 Dec;44(12):1783-1787

Department of Oral and Maxillofacial Pathology, School of Dentistry, Universidade de Pernambuco, Camaragibe, Pernambuco, Brazil.

Introduction: The purpose of this study was to evaluate the expression of cyclooxygenase-2 (COX-2) and tumor necrosis factor alpha (TNF-α) in periapical granuloma (PG) and radicular cyst (RC) samples and to correlate it with the type of lesion, the intensity of the inflammatory infiltrate, and the thickness of the epithelial lining.

Methods: A total of 51 cases of periapical lesions (25 PGs and 26 RCs) were subjected to morphologic analysis and immunohistochemical study. The anti-COX-2 and anti-TNF-α antibodies were applied using the immunoperoxidase technique. Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.002DOI Listing
December 2018
6 Reads

Biomimetic Conditioning of Human Dentin Using Citric Acid.

J Endod 2019 Jan 14;45(1):45-50. Epub 2018 Nov 14.

Department of Cranio-Maxillofacial and Oral Surgery, Oral Biotechnology and Bioengineering, University of Zurich, Zurich, Switzerland. Electronic address:

Introduction: In carious teeth, transforming growth factor beta 1 (TGF-β1) is released from the dentin matrix and possibly activated in an acidic environment. Conversely, EDTA solutions with a neutral to slightly alkaline pH are used in clinics to promote cell homing in regenerative endodontic procedures. We hypothesized that citric acid (CA) might be more beneficial. Read More

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January 2019
1 Read

Root Canal Shaping Using Nickel Titanium, M-Wire, and Gold Wire: A Micro-computed Tomographic Comparative Study of One Shape, ProTaper Next, and WaveOne Gold Instruments in Maxillary First Molars.

J Endod 2019 Jan 13;45(1):62-67. Epub 2018 Nov 13.

Department of Odontology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Introduction: The aim of this study was to evaluate the root canal shaping effect of instruments manufactured from nickel titanium, M-Wire, and Gold wire with different glide path preparation techniques.

Methods: One hundred thirty-five mesiobuccal canals of extracted human maxillary molars were randomly divided into 3 equal groups (N = 45) for glide path preparation with K-files (KF) (Dentsply Sirona, Ballaigues, Switzerland), One G (OG) files (Micro-Mega, Besançon, France), and ProGlider (PG) files (Dentsply Sirona). Specimens of each glide path group were further divided equally into 3 groups for instrumentation with ProTaper Next (PTN, Dentsply Sirona), One Shape (OS, Micro-Mega), and WaveOne Gold (WOG, Dentsply Sirona) systems (n = 15). Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.013DOI Listing
January 2019
9 Reads

Ludwig Angina after First Aid Treatment: Possible Etiologies and Prevention-Case Report.

J Endod 2019 Jan 13;45(1):79-82. Epub 2018 Nov 13.

Department of Endodontics, Israel Defense Forces Medical Corps, Tel Hashomer, Israel.

Ludwig angina is a life-threatening type of soft tissue cellulitis involving 3 compartments on the floor of the mouth including the submental, sublingual, and submandibular spaces bilaterally. Prevention, early recognition, and treatment of Ludwig angina are critical because this is a clinical diagnosis with unpredictable progression. This article describes a rare case of Ludwig angina that evolved from an odontogenic infection and the specific microbiology and clinical course and discusses possible etiologies and prevention. Read More

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http://dx.doi.org/10.1016/j.joen.2018.10.001DOI Listing
January 2019
12 Reads

Efficacy of Autologous Platelet Concentrates in Regenerative Endodontic Treatment: A Systematic Review of Human Studies.

J Endod 2019 Jan 13;45(1):20-30.e1. Epub 2018 Nov 13.

Department of Conservative Dentistry and Endodontics, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Introduction: The latest research concerns the use of platelet concentrates, which are introduced into the root canal. The aim of this study was to examine the effectiveness of platelet-rich fibrin and platelet-rich plasma in regenerative endodontics.

Methods: This literature review was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.003DOI Listing
January 2019
3 Reads

The Effect of Heating to Intracanal Temperature on the Stability of Sodium Hypochlorite Admixed with Etidronate or EDTA for Continuous Chelation.

J Endod 2019 Jan 13;45(1):57-61. Epub 2018 Nov 13.

School of Dentistry, The University of Queensland, Herston, Queensland, Australia.

Introduction: Tetrasodium etidronate (Na etidronate) and tetrasodium EDTA (Na EDTA) are chelators that can combine with sodium hypochlorite (NaOCl) as a 1-mix endodontic irrigant in a process called continuous chelation. The therapeutic window of these mixtures is determined by the chemical reaction between NaOCl and the chelator. At room temperature, this window is 60 minutes for Na etidronate and 30 minutes for Na EDTA. Read More

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http://dx.doi.org/10.1016/j.joen.2018.09.014DOI Listing
January 2019
2 Reads

Cyclic Fatigue Resistance of One Curve, 2Shape, ProFile Vortex, Vortex Blue, and RaCe Nickel-Titanium Rotary Instruments in Single and Double Curvature Canals.

J Endod 2018 Nov;44(11):1725-1730

Department of Dental Biomaterials, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.

Introduction: The aim of this study was to evaluate and compare the resistance to cyclic fatigue of the new One Curve (OC) instrument in double (S-shaped) and single curvature canals compared with other nickel-titanium rotary instruments.

Methods: Size 25/.06 of OC, 2Shape (TS), Vortex Blue (VB), ProFile Vortex (PV), and RaCe (RC) instruments were tested inside artificial canals with a single curvature (60° curvature, 5 mm radius) and double curvature (coronal curve, 60° curvature, 5 mm radius; and apical curve, 70° curvature and 2 mm radius) while immersed in saline at 37°C ± 1°C. Read More

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http://dx.doi.org/10.1016/j.joen.2018.07.023DOI Listing
November 2018
9 Reads