27,701,021 results match your criteria Journal of Emotional Abuse [Journal]

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Enhanced recovery after spine surgery: review of the literature

Neurosurg Focus 2019 Apr 1;46(4):E2. Epub 2019 Apr 1.

Department of Neurosurgery, Spine Unit, Geneva University Hospitals, Geneva, Switzerland; and

The concept of Enhanced Recovery After Surgery (ERAS) entails recovery facilitation of patients who undergo surgery through the implementation of a multidisciplinary and multimodal perioperative care approach. By its application, ERAS improves the overall functional outcome after surgery while maintaining high standards of care. A review of the essential aspects of ERAS in spine surgery was undertaken. Read More

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https://thejns.org/view/journals/neurosurg-focus/46/4/articl
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http://dx.doi.org/10.3171/2019.1.FOCUS18657DOI Listing
April 2019
3 Reads

What Interpersonal Problems Are Related to Different Therapeutic Techniques Early in Treatment?

Clin Psychol Psychother 2019 Apr 24. Epub 2019 Apr 24.

Derner School of Psychology, Adelphi University.

The current study seeks to explore the relationship between patient-reported interpersonal problems and therapist interventions in early psychodynamic psychotherapy for 71 outpatients. Pre-treatment ratings on the Inventory of Interpersonal Problems (IIP-C; Horowitz, Alden, Wiggins, & Pincus, 2000) total and subscale scores were examined in relation to early treatment process. Independent clinicians reliably rated therapist use of Psychodynamic-Interpersonal (PI) and Cognitive-Behavioral (CB) interventions using the CPPS (Hilsenroth, Blagys, Ackerman, Bonge, & Blais, 2005) over two early treatment sessions (3 & 9 ). Read More

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http://dx.doi.org/10.1002/cpp.2370DOI Listing

Neurofascin 140 and 155 antibodies in an atypical case of POEMS syndrome.

Muscle Nerve 2019 Apr 24. Epub 2019 Apr 24.

Dept. of Neurology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610.

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http://dx.doi.org/10.1002/mus.26493DOI Listing

Chemoradiation induces epithelial-to-mesenchymal transition in esophageal adenocarcinoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Medical Oncology, Amsterdam, The NetherlandsRadiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam.

Multimodality treatment has advanced the outcome of esophageal adenocarcinoma (EAC), but overall survival remains poor. Therapeutic pressure activates effective resistance mechanisms and we characterized these mechanisms in response to the currently used neoadjuvant treatment against EAC; carboplatin, paclitaxel and radiotherapy. We developed an in vitro approximation of this regimen and applied it to primary patient-derived cultures. Read More

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http://dx.doi.org/10.1002/ijc.32364DOI Listing

PD-(L)1 Inhibitors Versus Chemotherapy Versus Their Combination in Front-line Treatment for NSCLC: An Indirect Comparison.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

We comprehensively compared the therapeutic effects and safety of PD-1/L1 antibodies (I), chemotherapy (C) or their combination (I+C) as first-line treatments for advanced NSCLC. Online databases were searched to identify RCTs. Survival outcomes and safety events were pooled by indirect treatment comparison. Read More

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http://dx.doi.org/10.1002/ijc.32366DOI Listing

NK and T cell subsets in malignant mesothelioma patients: baseline pattern and changes in the context of anti-CTLA-4 therapy.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.

Malignant mesothelioma (MM) is a highly aggressive form of cancer with limited treatment options. Although the role of NK cells has been studied in many solid tumors, the pattern of NK cell subsets and their recognition of mesothelioma cells remains to be explored. We used RNA expression data of MM biopsies derived from the cancer genome atlas to evaluate the immune cell infiltrates. Read More

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http://dx.doi.org/10.1002/ijc.32363DOI Listing

Fisetin and 5-Fluorouracil: Effective Combination for PIK3CA-Mutant Colorectal Cancer.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

The normal colon epithelium is transformed into its neoplastic counterpart through a series of genetic alterations in driver genes including activating mutations in PIK3CA. Treatment often involves surgery followed by 5-fluorouracil (5-FU) based therapy, which has limited efficiency and serious side effects. We sought to determine whether fisetin, a dietary flavonoid, alone or in combination with 5-FU affected tumorigenesis in the mammalian intestine. Read More

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http://dx.doi.org/10.1002/ijc.32367DOI Listing

Impact of diagnosis and therapy on cognitive function in urea cycle disorders.

Ann Neurol 2019 Apr 24. Epub 2019 Apr 24.

Center for Pediatric and Adolescent Medicine, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.

Objective: Individuals with urea cycle disorders (UCDs) often present with intellectual and developmental disabilities. The major aim of this study was to evaluate the impact of diagnostic and therapeutic interventions on cognitive outcomes in UCDs.

Methods: This prospective, observational, multicenter study includes data from 503 individuals with UCDs who had comprehensive neurocognitive testing with a cumulative follow-up of 702 patient-years. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25492
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http://dx.doi.org/10.1002/ana.25492DOI Listing
April 2019
1 Read

Congenital Myasthenic Syndrome Type 19 due to a novel mutation in the COL13A1 gene.

Muscle Nerve 2019 Apr 24. Epub 2019 Apr 24.

Neuromuscular Center, Department of Neurology, Neurological Institute, Cleveland Clinic.

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http://dx.doi.org/10.1002/mus.26494DOI Listing

MiR-16-1-3p and miR-16-2-3p possess strong tumor suppressive and anti-metastatic properties in osteosarcoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, The Hebrew University-Hadassah Medical School at Ein-Kerem, Jerusalem, Israel.

Osteosarcoma (OS) is an aggressive malignancy affecting mostly children and adolescents. MicroRNAs (miRNAs) play important roles in OS development and progression. Here we found that miR-16-1-3p and miR-16-2-3p "passenger" strands as well as the "lead" miR-16-5p strand are frequently downregulated and possess strong tumor suppressive functions in human OS. Read More

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http://dx.doi.org/10.1002/ijc.32368DOI Listing

A retrospective alternative for active surveillance trials for ductal carcinoma in situ of the breast.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Ductal carcinoma in situ (DCIS) of the breast is a non-obligate precursor of invasive breast cancer, accounting for twenty percent of screen-detected breast cancers. Little is known about the natural progression of DCIS, because most patients undergo surgery upon diagnosis. Many DCIS patients are likely being over-treated, as it is believed that only around fifty percent of DCIS will progress to invasive carcinoma. Read More

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http://dx.doi.org/10.1002/ijc.32362DOI Listing
April 2019
2 Reads

Diabetes mellitus, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Genetic variation in the insulin-like growth factor (IGF) pathway may further increase the risk of colorectal cancer (CRC) associated with type 2 diabetes mellitus (T2DM). Joint effects of T2DM and genetic variation in the IGF pathway on CRC risk can increase mechanistic insights. Participants from the Netherlands Cohort Study (n=120,852) completed a baseline questionnaire in 1986 when 55-69 years old (case-cohort, n subcohort=5,000, n cases = 3,441 after 16. Read More

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http://dx.doi.org/10.1002/ijc.32365DOI Listing

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Equipe SiRIC RTOP Recherche Translationelle en Oncologie Pédiatrique, Institut Curie, Paris, France.

In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were analyzed in tumor samples from 283 NB patients, with constitutional material available for 55 patients. Read More

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http://dx.doi.org/10.1002/ijc.32361DOI Listing

Spontaneous Aortocaval Fistula with Abdominal Aortic Aneurysm 5 Years after Aortic Valve Replacement Complicated by Aortic Dissection.

Aorta (Stamford) 2018 Dec 24;6(6):145-146. Epub 2019 Apr 24.

Department of Cardiovascular and Thoracic Surgery, Medical University of Tunis, Rabta Hospital, Tunis, Tunisia.

Iatrogenic aortic dissection after cardiac surgery is a rare and serious complication, the management of which involves many therapeutic modalities and whose prognosis is associated with high rate of morbidity and mortality. The authors report the case of a 61-year-old man presented with aortocaval fistula and aortic dissection 5 years after aortic valve replacement. Read More

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http://dx.doi.org/10.1055/s-0039-1683882DOI Listing
December 2018

Spontaneous Early Resolution of an Iatrogenic Type A Aortic Dissection Following Coronary Angiography.

Aorta (Stamford) 2018 Dec 24;6(6):142-144. Epub 2019 Apr 24.

Department of Anesthesiology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.

A 74-year-old man was admitted with the diagnosis of non-ST-elevation myocardial infarction. During right coronary angiography, a coronary artery dissection extending into the proximal ascending aorta was noticed without hemodynamic compromise. Immediate computed tomography angiography showed no evidence of dissection in the ascending aorta. Read More

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http://dx.doi.org/10.1055/s-0039-1683956DOI Listing
December 2018

Case Report of an Infrequent Complication of Infective Endocarditis: The Complete Detachment from the Aorta of the Previous Vein Graft Anastomosis.

Aorta (Stamford) 2018 Dec 24;6(6):139-141. Epub 2019 Apr 24.

Department of Cardiovascular Surgery, Ramon y Cajal Hospital, Madrid, Spain.

The authors report an unusual complication of acute infective endocarditis found in a 70-year-old man with a previous history of two cardiac surgery procedures. During median sternotomy, a massive bleeding occurred. The bleeding was contained within the mediastinum and originated from the 10-year-old anastomosis of the saphenous vein to a composite graft, which was completely detached due to infective endocarditis of the aortic graft. Read More

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http://dx.doi.org/10.1055/s-0039-1678554DOI Listing
December 2018

Head and Neck Pain in Patients Presenting with Acute Aortic Dissection.

Aorta (Stamford) 2018 Dec 24;6(6):130-138. Epub 2019 Apr 24.

Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.

Background:  Head and neck pain is an atypical presentation of acute aortic dissection. Classic teaching associates this pain with proximal dissections, but this has not been extensively studied.

Methods:  Patients enrolled in the International Registry of Acute Aortic Dissection from January 1996 to March 2015 were included in this study. Read More

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http://dx.doi.org/10.1055/s-0039-18388DOI Listing
December 2018

Single Low-Volume Center Experience with Frozen Elephant Trunk in Acute Type A Aortic Dissections.

Aorta (Stamford) 2018 Dec 24;6(6):125-129. Epub 2019 Apr 24.

Department of Cardiac Surgery, Virgen de la Salud Hospital, Toledo, Spain.

Background:  Acute Type A aortic dissection (AAAD) is a surgical emergency. In patients with arch and descending aorta involvement (DeBakey Type I), a total aortic arch replacement with frozen elephant trunk (FET) could favor false lumen thrombosis and improve long-term results. The authors hereby present their experience with this technique in a single low-volume center, to assess whether the technique is feasible to treat such disease. Read More

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http://dx.doi.org/10.1055/s-0039-1677809DOI Listing
December 2018

Composer-Visual Cohort Analysis of Patient Outcomes.

Appl Clin Inform 2019 Mar 24;10(2):278-285. Epub 2019 Apr 24.

Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States.

Objective:  Visual cohort analysis utilizing electronic health record data has become an important tool in clinical assessment of patient outcomes. In this article, we introduce Composer, a visual analysis tool for orthopedic surgeons to compare changes in physical functions of a patient cohort following various spinal procedures. The goal of our project is to help researchers analyze outcomes of procedures and facilitate informed decision-making about treatment options between patient and clinician. Read More

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http://dx.doi.org/10.1055/s-0039-1687862DOI Listing

Quality Informatics: The Convergence of Healthcare Data, Analytics, and Clinical Excellence.

Appl Clin Inform 2019 Mar 24;10(2):272-277. Epub 2019 Apr 24.

Warren Alpert Medical School and Center for Biomedical Informatics, Brown University, Rhode Island, United States.

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http://dx.doi.org/10.1055/s-0039-1685221DOI Listing

Bewegte Zeiten.

Authors:
Manfred Wildner

Gesundheitswesen 2019 Apr 24;81(4):297-298. Epub 2019 Apr 24.

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http://dx.doi.org/10.1055/a-0874-4169DOI Listing

Profile of Pregnant Women with Gestational Diabetes Mellitus at Increased Risk for Large for Gestational Age Newborns.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Endocrinology Unit of University Hospital, Universidade Federal do Maranhão, São Luís, MA, Brazil.

Objective:  Gestational diabetes mellitus (GDM) is associated with a higher risk of perinatal morbidity and mortality, and its main complication is the occurrence of large for gestational age (LGA) newborns. The present study aims to characterize pregnant women with GDM and to identify factors associated with the occurrence of LGA newborns in this population.

Methods:  A cross-sectional study was performed based on medical records of women whose prenatal care and delivery were performed at the Maternal and Child Unit of the Hospital Universitário of the Universidade Federal do Maranhão, state of Maranhão, Brazil. Read More

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http://dx.doi.org/10.1055/s-0039-1687860DOI Listing

Laparoscopic Box Training with Four Different Modules in a Tertiary Education and Research Hospital, Ankara, Turkey.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Department of Obstetrics and Gynecology, University of Health Sciences, Etlik Zubeyde Hanim Women's Health Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1055/s-0039-1688411DOI Listing

A Case of Chronic and Relapsing Paget Disease of the Vulva.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatovenereology, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal.

Extramammary Paget disease is a rare neoplastic condition that more commonly affects postmenopausal Caucasian women. Although the vulvar area is the most frequently affected location, it corresponds solely to 1 to 2% of all vulvar malignancies. A 72-year-old female patient was observed in our outpatient clinic with a 2-year history of an erythematous and pruritic plaque on the vulva. Read More

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http://dx.doi.org/10.1055/s-0039-1687861DOI Listing
April 2019
1 Read

Minimally Invasive Craniocervical Decompression for Chiari 1 Malformation: An Operative Technique.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Seoul St. Mary's Hospital, Seocho Gu, Seoul, Korea, Republic of.

Chiari malformation type 1 (CM-1) is an ectopia of the cerebellar tonsils below the foramen magnum that causes severe disability due to its neurologic symptoms. The treatment of choice for CM-1 is decompression of the craniovertebral junction (CVJ). In some patients only an extradural decompression by removing the atlanto-occipital ligament may be sufficient. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685
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http://dx.doi.org/10.1055/s-0039-1685DOI Listing
April 2019
4 Reads

Retrieval of a Subcutaneous Needle using High-frequency Ultrasound.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Zentralklinik, Bad Berka, Germany.

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http://dx.doi.org/10.1055/s-0038-1676593DOI Listing

Long-term Outcomes of Microvascular Decompression in the Treatment of Hemifacial Spasm Based on Different Offending Vessels.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, China.

Objective:  To evaluate clinical features, outcomes, and complications in patients with hemifacial spasm (HFS) after microvascular decompression (MVD) of different offending vessels.

Methods:  Clinical data were collected from 362 patients with HFS treated with MVD between January 2013 and January 2014. Patients were divided into five groups based on the offending vessel: A (anterior inferior cerebellar artery [AICA] compression), B (posterior inferior cerebellar artery [PICA] compression), C (AICA plus PICA compression), D (vertebral artery [VA] compression), and E (VA plus small vessel compression). Read More

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http://dx.doi.org/10.1055/s-0039-1685199DOI Listing

Reducing Surgeon's Physical Stress in Minimally Invasive Neurosurgery.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background And Study Aims:  Various minimally invasive approaches are used in neurosurgery. Surgeons must perform nondynamic fine movements in a narrow corridor, so specially designed surgical devices are essential. Unsophisticated instruments may pose potential hazards. Read More

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http://dx.doi.org/10.1055/s-0038-1676622DOI Listing
April 2019
1 Read

Do Complication Rates of Ventricular Drain Placement Differ between Twist Drill and Burr Hole in Acute Hydrocephalus?

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Universitätsklinikum Ulm, Ulm, Germany.

Objective:  The aim of the study was to compare two techniques for external ventricular drainage (EVD) placement with respect to their complication rates.

Methods:  A retrospective descriptive study was performed to analyze all patients who had undergone EVD implantation for acute hydrocephalus between January 2010 and December 2013 with a focus on surgical technique and rate of complications. The burr hole technique (BHT) was used in one group and the twist-drill technique (TDT) in the other. Read More

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http://dx.doi.org/10.1055/s-0039-1685195DOI Listing
April 2019
2 Reads

Maintenance of Integrity of Upper Facet Joints during Simulated Percutaneous Pedicle Screw Insertion Using 2D versus 3D Planning.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, University of Mainz, Mainz, Germany.

Background:  No studies have directly and quantitatively compared two-dimensional (2D) and three-dimensional (3D) planning as applied during conventional percutaneous or navigated percutaneous pedicle screw placement.

Study Aims:  This lumbar pedicle-based stabilization simulation study aimed to investigate the risk of upper facet joint violation (FJV) during posterior percutaneous pedicle screw placement with conventional 2D planning of screw implantation (as a model for fluoroscopically guided screws) compared with 3D planning (as used with navigation techniques).

Methods:  The placement of monosegmental lumbar pedicle screws using the data sets of 250 consecutive patients was simulated. Read More

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http://dx.doi.org/10.1055/s-0039-1681042DOI Listing

Preoperative Considerations in Occipital Artery-high-riding Posterior Inferior Cerebellar Artery Bypass: A Report of Two Cases and a Literature Review.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, Chonnam Nat' University Medical School and Hospital, Gwangju, Korea, Republic of.

Nonsaccular vertebral artery aneurysms involving the posterior inferior cerebellar artery (PICA) are rare. Treatment is considered a significant challenge because of their angiographic and anatomical features, especially in high-riding PICA. Therefore, meticulous preoperative angiographic and anatomical evaluation is necessary. Read More

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http://dx.doi.org/10.1055/s-0039-1684025DOI Listing

Using Artificial Intelligence to Identify Factors Associated with Autism Spectrum Disorder in Adolescents with Cerebral Palsy.

Neuropediatrics 2019 Apr 24. Epub 2019 Apr 24.

Department of Pediatric Orthopaedic Surgery, Lenval University Pediatric Hospital of Nice, Nice, France.

Autism spectrum disorder (ASD) is common in adolescents with cerebral palsy (CP) and there is a lack of studies applying artificial intelligence to investigate this field and this population in particular. The aim of this study is to develop and test a predictive learning model to identify factors associated with ASD in adolescents with CP. This was a multicenter controlled cohort study of 102 adolescents with CP (61 males, 41 females; mean age ± SD [standard deviation] = 16. Read More

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http://dx.doi.org/10.1055/s-0039-1685525DOI Listing

Platelet Activation by Antiphospholipid Antibodies Depends on Epitope Specificity and is Prevented by mTOR Inhibitors.

Thromb Haemost 2019 Apr 24. Epub 2019 Apr 24.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany.

Antiphospholipid antibodies (aPL) have been reported to activate platelets. This is considered to be one of the pathogenic properties of aPL. Even though aPL heterogeneity is quite well established, little is known, if the ability to activate platelets is common to all aPL or depends on antigen specificity. Read More

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http://dx.doi.org/10.1055/s-0039-1685453DOI Listing

Quercus ilex Extract Ameliorates Acute TNBS-Induced Colitis in Rats.

Planta Med 2019 Apr 24. Epub 2019 Apr 24.

Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain.

L. (Fagaceae) is one of the most commonly used plants in folk medicine in the Mediterranean region to treat gastrointestinal disorders. The aim of the present study was to evaluate the effects of a polyphenol extract from mature leaves of on acute 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. Read More

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http://dx.doi.org/10.1055/a-0889-6132DOI Listing

Language Specificity in Phonetic Cue Weighting: Monolingual and Bilingual Perception of the Stop Voicing Contrast in English and Spanish.

Phonetica 2019 Apr 24:1-23. Epub 2019 Apr 24.

Department of Speech, Language and Hearing Sciences, University of Florida, Gainesville, Florida, USA.

Background/aims: This work examines the perception of the stop voicing contrast in Spanish and English along four acoustic dimensions, comparing monolingual and bilingual listeners. Our primary goals are to test the extent to which cue-weighting strategies are language-specific in monolinguals, and whether this language specificity extends to bilingual listeners.

Methods: Participants categorized sounds varying in voice onset time (VOT, the primary cue to the contrast) and three secondary cues: fundamental frequency at vowel onset, first formant (F1) onset frequency, and stop closure duration. Read More

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http://dx.doi.org/10.1159/000497278DOI Listing

Laryngeal Contrast in Qatari Arabic: Effect of Speaking Rate on Voice Onset Time.

Authors:
Vladimir Kulikov

Phonetica 2019 Apr 24:1-23. Epub 2019 Apr 24.

Department of English Literature and Linguistics, Qatar University, Doha, Qatar,

Beckman and colleagues claimed in 2011 that Swedish has an overspecified phonological contrast between prevoiced and voiceless aspirated stops. Yet, Swedish is the only language for which this pattern has been reported. The current study describes a similar phonological pattern in the vernacular Arabic dialect of Qatar. Read More

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http://dx.doi.org/10.1159/000497277DOI Listing

Towards a Phenomenology of Self-Patterns in Psychopathological Diagnosis and Therapy.

Psychopathology 2019 Apr 24:1-17. Epub 2019 Apr 24.

Lillian and Morrie Moss Chair of Excellence in Philosophy, Department of Philosophy, University of Memphis, Memphis, Tennessee, USA.

Categorization-based diagnosis, which endeavors to be consistent with the third-person, objective measures of science, is not always adequate with respect to problems concerning diagnostic accuracy, demarcation problems when there are comorbidities, well-documented problems of symptom amplification, and complications of stigmatization and looping effects. While psychiatric categories have proved useful and convenient for clinicians in identifying a recognizable constellation of symptoms typical for a particular disorder for the purposes of communication and eligibility for treatment regimes, the reification of these categories has without doubt had negative consequences for the patient and also for the general understanding of psychiatric disorders. We argue that a complementary, integrated framework that focuses on descriptive symptom-based classifications (drawing on phenomenological interview methods and narrative) combined with a more comprehensive conception of the human subject (found in the pattern theory of self), can not only offer a solution to some of the vexed issues of psychiatric diagnosis but also support more efficacious therapeutic interventions. Read More

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http://dx.doi.org/10.1159/000499315DOI Listing

The Low-Cost, Long-Term Indwelling Pleural Catheter (LunGO): An Inexpensive and Effective Alternative for the Management of Dyspnea Associated with Malignant Pleural Effusions.

Respiration 2019 Apr 24:1-6. Epub 2019 Apr 24.

Thoracic Surgeon at Hospital Santa Marcelina de Itaquera, São Paulo, Brazil.

Background: A malignant pleural effusion (MPE) in patients with cancer is evidence of the underlying disease progression, resulting in many symptoms, and may lead to hospitalization. The treatment options include talc pleurodesis (TP) or the implantation of an indwelling pleural catheter. The costs of the latter approach are often seen to be inhibitive for the Brazilian and other emerging markets' public health system. Read More

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http://dx.doi.org/10.1159/000498971DOI Listing
April 2019
1 Read

Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro.

Skin Pharmacol Physiol 2019 Apr 24;32(3):162-172. Epub 2019 Apr 24.

Institute for Translational Wound Research, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany.

Background: The number of patients who has a daily intake of antihypertensive drugs is rising, due to an also rising prevalence of lifestyle diseases. Interestingly, knowledge about effects of these drugs in terms of wound healing is low.

Objective: Based on a few differing studies, the idea arose that antihypertensives may have side effects on wound healing. Read More

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http://dx.doi.org/10.1159/000499433DOI Listing
April 2019
1 Read

Assessing Inspiratory Muscle Strength for Early Detection of Respiratory Failure in Motor Neuron Disease: Should We Use MIP, SNIP, or Both?

Respiration 2019 Apr 24:1-11. Epub 2019 Apr 24.

Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.

Background: Motor neuron disease (MND) invariably impacts on inspiratory muscle strength leading to respiratory failure. Regular assessment of sniff nasal inspiratory pressure (SNIP) and/or maximal mouth inspiratory pressure (MIP) contributes to early detection of a requirement for ventilatory support.

Objectives: The aim of this study was to compare the feasibility, agreement, and performance of both tests in MND. Read More

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http://dx.doi.org/10.1159/000498972DOI Listing

Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions.

Nephron 2019 Apr 24:1-5. Epub 2019 Apr 24.

Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Sepsis-associated acute kidney injury (S-AKI) significantly worsens patient prognosis, and recent evidence suggests that the injury process begins early and may be sustained by therapies used to treat the sepsis (e.g., fluids resuscitation, antibiotics). Read More

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https://www.karger.com/Article/FullText/500167
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http://dx.doi.org/10.1159/000500167DOI Listing
April 2019
1 Read

Pleural Cryobiopsy versus Flexible Forceps Biopsy in Subjects with Undiagnosed Exudative Pleural Effusions Undergoing Semirigid Thoracoscopy: A Crossover Randomized Trial (COFFEE Trial).

Respiration 2019 Apr 24:1-9. Epub 2019 Apr 24.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India,

Background: There is no randomized study comparing pleural cryobiopsy (CB) and flexible forceps biopsy (FFB) in subjects undergoing medical thoracoscopy for the diagnosis of pleural effusions.

Objective: In this crossover study, we compared the diagnostic yield of CB versus FFB in subjects undergoing semirigid thoracoscopy.

Methods: Subjects undergoing semirigid thoracoscopy for undiagnosed pleural effusions were subjected to both CB and FFB, with the order of performing the biopsy randomized in a 1:1 ratio. Read More

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http://dx.doi.org/10.1159/000497212DOI Listing

PLAC8 is overexpressed and regulates cell proliferation in low-grade human PanNET.

Neuroendocrinology 2019 Apr 25. Epub 2019 Apr 25.


Background/Aims: Many aspects of the biology of pancreatic neuroendocrine tumors (PanNETs), including determinants of proliferative, invasive and metastatic potential, remain poorly understood. Placenta-specific 8 (PLAC8), a gene with unknown molecular function, has been reported to have tumor-promoting roles in different human malignancies, including exocrine pancreatic cancer. Since preliminary data suggested deregulation of PLAC8 expression in PanNET, we have performed detailed analyses of PLAC8 expression and function in human PanNET. Read More

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http://dx.doi.org/10.1159/000500541DOI Listing

The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress.

Ophthalmic Res 2019 Apr 24:1-13. Epub 2019 Apr 24.

The First Clinical Medical College of Lanzhou University, Lanzhou, China.

This study aimed to evaluate the therapeutic effect of folic acid (FA) on diabetic retinopathy (DR) in a genetic mouse model of obese type 2 diabetes mellitus (T2D). C57BL/KsJ-db/db (db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group). Serum levels of glucose, glycated hemoglobin, and insulin were determined weekly. Read More

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http://dx.doi.org/10.1159/000499020DOI Listing

Autophagy in Pulmonary Innate Immunity.

J Innate Immun 2019 Apr 24:1-10. Epub 2019 Apr 24.

Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular macromolecules and dysfunctional organelles and regeneration of nutrients for cell growth. Autophagy is important in innate immunity, as it is responsible for the clearance of various pathogens. Read More

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http://dx.doi.org/10.1159/000497414DOI Listing
April 2019
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Inspiratory and Expiratory Flow Changes, Voice Symptoms and Laryngeal Findings during Histamine Challenge Tests.

Folia Phoniatr Logop 2019 Apr 24:1-7. Epub 2019 Apr 24.

Department of Otorhinolaryngology and Phoniatrics, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Objective: The aim of this study was to analyse the associations between the spirometry parameter changes in relation to laryngeal finding changes and self-reported voice and throat symptom changes among patients undergoing a histamine challenge test.

Patients And Methods: Thirty adult patients with a chronic cough underwent a histamine challenge test. Videolaryngostroboscopy and voice and throat symptoms were assessed using a visual analogue scale immediately before and after the challenge test. Read More

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http://dx.doi.org/10.1159/000495783DOI Listing

Role of Ancillary Techniques in Fluid Cytology.

Acta Cytol 2019 Apr 24:1-11. Epub 2019 Apr 24.

Hospital of the University of Pennsylvania, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

The cytologic evaluation of serous effusions may be challenging for a number of reasons. Distinction of benign, reactive conditions from malignancy represents the main focus when examining these specimens. The morphologic diagnosis of malignancy may be difficult due to the relative paucity of abnormal cells. Read More

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http://dx.doi.org/10.1159/000496568DOI Listing

No Difference in Prevalence of Transmitted Drug Resistance between Injection Drug Users and Non-Injection Drug Users: A Cross-Sectional Study among Antiretroviral Treatment-Naïve HIV Patients.

Intervirology 2019 Apr 24:1-11. Epub 2019 Apr 24.

Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, China,

Objectives: The epidemiological evidence is inconsistent about whether HIV-positive injection drug users (IDUs) are at higher risk of developing antiretroviral resistance than any other HIV-positive populations. This study aims to investigate and compare transmitted drug resistance (TDR) between IDUs and non-IDUs in Lingshan County, an HIV-hit region in Guangxi, China, where IDU and heterosexual transmission were the two dominant transmission routes and roughly equally contributed to the local HIV transmission.

Methods: A cross-sectional study was conducted among newly diagnosed and antiretroviral-treatment (ART)-naïve HIV-1 patients from Lingshan County. Read More

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https://www.karger.com/Article/FullText/499367
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http://dx.doi.org/10.1159/000499367DOI Listing
April 2019
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