968 results match your criteria Journal of Diabetes [Journal]


A Prospective Study of Gestational Diabetes and Fatty Liver Scores 9-16 Years After Pregnancy.

J Diabetes 2019 Apr 19. Epub 2019 Apr 19.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States.

Background: Women with gestational diabetes mellitus (GDM) may be at an increased risk for liver complications as chronic hyperglycemia is a risk factor for liver fat accumulation and potential liver dysfunction. Large prospective studies examining liver fat accumulation following a GDM pregnancy are lacking.

Methods: In the Diabetes & Women's Health (DWH) Study (2012-2014) we examined the association between GDM and subsequent fatty liver scores among 607 women with and 619 women without GDM in the Danish National Birth Cohort (DNBC). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1753-0407.12
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http://dx.doi.org/10.1111/1753-0407.12934DOI Listing
April 2019
1 Read

Decreased cortisol response to low-dose Synacthen test in pediatric patients with type 1 diabetes.

J Diabetes 2019 Apr 19. Epub 2019 Apr 19.

1st Department of Pediatrics, School of Medicine, Faculty of Health Science, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1753-0407.12
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http://dx.doi.org/10.1111/1753-0407.12935DOI Listing
April 2019
1 Read

Hypoglycemia in Diabetes: The Dark Side of Diabetes Treatment A Patient Centered Review.

J Diabetes 2019 Apr 15. Epub 2019 Apr 15.

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Hypoglycemia is a frequent occurrence in patients with diabetes who are treated with insulin and insulin secretagogues. Hypoglycemia is the limiting factor that prevents patients from achieving the glycemia control known to reduce the microvascular complications of diabetes. Recurrent episodes of hypoglycemia can lead to impaired awareness of hypoglycemia where the first symptom of a low blood sugar is unconsciousness. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1753-0407.12
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http://dx.doi.org/10.1111/1753-0407.12933DOI Listing
April 2019
2 Reads

Effect of basal insulin supplement therapy on diabetic retinopathy in short-duration type 2 diabetes:a one-year randomized parallel-group trial.

J Diabetes 2019 Apr 11. Epub 2019 Apr 11.

Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: It is unknown which subsequent treatments benefit diabetic retinopathy (DR). We compared the effects of oral anti-diabetic drugs (OADs) alone and basal insulin-supported OAD therapy (BOT) on DR.

Methods: Two hundred ninety patients, aged 18-65 years, with diabetic durations of 0-5 years, were enrolled between January 2015 and January 2018. Read More

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http://dx.doi.org/10.1111/1753-0407.12928DOI Listing
April 2019
1 Read

Resting heart rate is associated with metabolic syndrome and predicted 10-Year risk of cardiovascular disease: A cross-sectional study.

J Diabetes 2019 Apr 2. Epub 2019 Apr 2.

Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.

Background: The purpose of the study was to demonstrate whether resting heart rate (RHR) was associated with metabolic syndrome (MetS) and 10-year predicted risk of cardiovascular disease in Chinese population.

Methods: The associations of RHR with MetS and 10-year risk of atherosclerotic cardiovascular diseases (ASCVD) was examined in a cross-sectional study conducted in Shanghai, China (n= 9,486).

Results: Compared with individuals in the lowest quintile [≤71 bpm (beats per minute)], those in the highest quintile (≥91 bpm) of RHR had a higher prevalence of MetS (21. Read More

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http://dx.doi.org/10.1111/1753-0407.12927DOI Listing
April 2019
2 Reads

What constitutes good research?

J Diabetes 2019 Mar 27. Epub 2019 Mar 27.

Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

No abstract is available for this article. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/1753-0407.12924DOI Listing

Genetic predisposition to gestational glucose metabolism and gestational diabetes mellitus risk in a Chinese population.

J Diabetes 2019 Mar 26. Epub 2019 Mar 26.

Women's Hospital of Nanjing Medical University, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.

Background: Genome-wide association studies (GWAS) have identified several genetic variants influencing gestational glucose metabolism. However, their known associations with gestational diabetes mellitus (GDM) risk are still scarce.

Methods: In the present study, we aimed to examine the associations of 12 gestational glucose metabolism-related variants with GDM risk in a Chinese population (964 GDM cases and 1,021 controls). Read More

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http://dx.doi.org/10.1111/1753-0407.12923DOI Listing
March 2019
1 Read

Effects of variants of 50 genes on diabetes risk among Chinese population born in early 1960s.

J Diabetes 2019 Mar 24. Epub 2019 Mar 24.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: Genome-wide association studies have identified some loci that significantly increase diabetes risk. This study was to explore the genetic susceptibility in relation to diabetes risk in adulthood among Chinese population born in early 1960s.

Methods: Totally 2129 subjects (833 males, 1296females) were selected from the cross-sectional 2010-2012 China National Nutrition and Health Survey (CNNHS). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1753-0407.12
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http://dx.doi.org/10.1111/1753-0407.12922DOI Listing
March 2019
1 Read

Dose-response relationships between dairy intake and chronic metabolic diseases in a Chinese population.

J Diabetes 2019 Mar 22. Epub 2019 Mar 22.

Emergency Department, The Second Affiliated Hospital of Harbin Medical University, No. 246 Baojian Road, Nangang District, Harbin, 150081, China.

Background: To investigate the associations between dairy intake and chronic metabolic diseases (CMDs) and evaluate the possible dose-response relationships in Chinese.

Methods: This cross-sectional study included 6073 adults aged ≥18 y, enrolled from China. General characteristics were gathered by using a validated dietary questionnaire. Read More

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http://dx.doi.org/10.1111/1753-0407.12921DOI Listing
March 2019
1 Read

Diabetes news.

J Diabetes 2019 Mar 20. Epub 2019 Mar 20.

Close Concerns, San Francisco, California.

Martin J. Kurian, Peter J. Rentzepis, Ann M. Read More

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http://dx.doi.org/10.1111/1753-0407.12920DOI Listing

"Adjusting internal organs and dredging channel" electroacupuncture treatment prevents the development of diabetic peripheral neuropathy by downregulating GRP78 and caspase-12 in streptozotocin-diabetic rats.

J Diabetes 2019 Mar 18. Epub 2019 Mar 18.

Changchun University of Chinese Medicine, Changchun, China.

Background: Clinical efficacy of electroacupuncture in treating diabetic peripheral neuropathy (DPN) is really significant, but its action mechanism is not yet clear. Considering that glucose-regulated protein 78 (GRP78) and caspase-12 are major proteins which participate in cell apoptosis, we investigated the effects of "adjusting internal organs and dredging channel" electroacupuncture therapy on the levels of GRP78 and caspase-12 in streptozotocin-diabetic rats to elucidate its action mechanism.

Methods: The rats were randomly divided into model control group, electroacupuncture intervention group, mecobalamine intervention group by single injection of streptozotocin at a dose of 50 mg/kg, and normal control group which received injections of equivalent dose of citrate buffer. Read More

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http://dx.doi.org/10.1111/1753-0407.12916DOI Listing
March 2019
1 Read

Current understanding of the role of gut dysbiosis in type 1 diabetes.

J Diabetes 2019 Mar 13. Epub 2019 Mar 13.

Department of Surgery-Transplant, University of Nebraska Medical Center, Omaha, Nebraska.

Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from destruction of the insulin-producing pancreatic β-cells. The disease mainly affects juveniles. Changes in the composition of the gut microbiota (dysbiosis) and changes in the properties of the gut barrier have been documented in T1D subjects. Read More

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http://dx.doi.org/10.1111/1753-0407.12915DOI Listing
March 2019
1 Read

Inhibition of high mobility group box 1 (HMGB1) attenuates podocyte apoptosis and epithelial-mesenchymal transition by regulating autophagy flux.

J Diabetes 2019 Mar 12. Epub 2019 Mar 12.

Department of Nephrology, Zhejiang Provincial People's Hospital, Zhejiang, China.

Background: Podocyte injury, characterized by podocyte hypertrophy, apoptosis, and epithelial-mesenchymal transition (EMT), is the major causative factor of diabetic nephropathy (DN). Autophagy dysfunction is regarded as the major risk factor for podocyte injury including EMT and apoptosis. High mobility group box 1 (HMGB1) is involved in the progression of DN through the induction of autophagy. Read More

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http://dx.doi.org/10.1111/1753-0407.12914DOI Listing

Diabetes in developing countries.

J Diabetes 2019 Mar 12. Epub 2019 Mar 12.

Shree Hindu Mandal Hospital, Tanzania.

There has been a rapid escalation of type 2 diabetes (T2D) in developing countries, with varied prevalence according to rural vs urban habitat and degree of urbanization. Some ethnic groups (eg, South Asians, other Asians, and Africans), develop diabetes a decade earlier and at a lower body mass index than Whites, have prominent abdominal obesity, and accelerated the conversion from prediabetes to diabetes. The burden of complications, both macro- and microvascular, is substantial, but also varies according to populations. Read More

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http://dx.doi.org/10.1111/1753-0407.12913DOI Listing
March 2019
3 Reads

Prognosis for residual islet β-cell secretion function in young patients with newly diagnosed type 1 diabetes.

J Diabetes 2019 Mar 7. Epub 2019 Mar 7.

Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-Tong University, Shanghai, China.

Background: This study investigated possible predictors of residual islet β-cell function (RBF) in young patients with newly diagnosed type 1 diabetes (T1D).

Methods: After analyzing RBF in 443 patients with T1D according to age at diagnosis and disease duration, 110 were followed-up over 18-60 months. A nomogram was developed by logistic regression to explore factors associated with long-term RBF. Read More

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http://dx.doi.org/10.1111/1753-0407.12912DOI Listing
March 2019
2 Reads

Delayed response to an injection of U-500 regular insulin is not rare.

Authors:
Mayer B Davidson

J Diabetes 2019 Feb 28. Epub 2019 Feb 28.

Department of Internal Medicine, Charles R. Drew University, Los Angeles, California.

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http://dx.doi.org/10.1111/1753-0407.12911DOI Listing
February 2019

Beyond HbA1c, second take.

J Diabetes 2019 Feb 22. Epub 2019 Feb 22.

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1111/1753-0407.12910DOI Listing
February 2019

Ethnic differences in prevalence, risk factors, and perinatal outcomes of gestational diabetes mellitus: A comparison between immigrant ethnic Chinese women and Australian-born Caucasian women in Australia.

J Diabetes 2019 Feb 18. Epub 2019 Feb 18.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.

Background: The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide. Ethnic differences in risk factors and perinatal outcomes are clinically important. Chinese women constitute approximately 10% of the world's population, and are an increasing migrant population, yet prevalence, risk factors, and outcomes of GDM in this population are insufficiently explored. Read More

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http://dx.doi.org/10.1111/1753-0407.12909DOI Listing
February 2019
2 Reads

Nocturnal ventricular arrhythmias are associated with the severity of cardiovascular autonomic neuropathy in type 2 diabetes.

J Diabetes 2019 Feb 15. Epub 2019 Feb 15.

Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.

Background: Cardiovascular autonomic neuropathy (CAN) is a risk factor for arrhythmias and adverse cardiovascular events, but the relationship between CAN severity and nocturnal arrhythmias needs to be clarified. This study evaluated the association between nocturnal arrhythmias and CAN severity in patients with type 2 diabetes (T2D).

Methods: In all, 219 T2D patients were recruited from January 2017 to May 2018. Read More

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http://dx.doi.org/10.1111/1753-0407.12908DOI Listing
February 2019
2 Reads

Tapering decay of β-cell function in Chinese patients with autoimmune type 1 diabetes: A four-year prospective study.

J Diabetes 2019 Feb 14. Epub 2019 Feb 14.

Institute of Metabolism and Endocrinology, The Second Xiangya Hospital and the Diabetes Center, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, National Clinical Research Center for Metabolic Diseases, Changsha, China.

Background: This study investigated the natural progression of β-cell function in Chinese autoimmune type 1 diabetic (T1D) patients and clarified factors possibly influencing the course of the disease.

Methods: The natural progression of β-cell function of 325 newly diagnosed Chinese autoimmune T1D patients was assessed by fasting and postprandial C-peptide (FCP and PCP, respectively) levels. β-Cell function failure was defined as FCP <50 pM and PCP <100 pM, whereas preserved β-cell function was defined as FCP >200 pM or PCP >400 pM. Read More

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http://dx.doi.org/10.1111/1753-0407.12907DOI Listing
February 2019
2 Reads

Roux-en-Y gastric bypass decreases endotoxemia and inflammatory stress in association with improvements in gut permeability in obese diabetic rats.

J Diabetes 2019 Feb 3. Epub 2019 Feb 3.

Department of Endocrinology, Changhai Hospital, The Second Military Medical University, Shanghai, China.

Background: Postoperative modulation of the gut microbiome has been suggested to contribute to the metabolic benefits after metabolic surgery, but the mechanisms underlying these metabolic benefits remain unknown. Previously, we reported that Roux-en-Y gastric bypass (RYGB) surgery in Zucker diabetic fatty (ZDF) rats increased the abundance of Proteobacteria and Gammaproteobacteria. However, theoretically, these Gram-negative bacteria may elevate lipopolysaccharide (LPS) levels. Read More

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http://dx.doi.org/10.1111/1753-0407.12906DOI Listing
February 2019

Real-world experience of metformin use in pregnancy: Observational data from the Northern Territory Diabetes in Pregnancy Clinical Register.

J Diabetes 2019 Jan 25. Epub 2019 Jan 25.

Population Health Research, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

Background: In Australia's Northern Territory, Indigenous mothers account for 33% of births and have high rates of hyperglycemia in pregnancy. The prevalence of type 2 diabetes (T2D) in pregnancy is up to 10-fold higher in Indigenous than non-Indigenous Australian mothers, and the use of metformin is common. We assessed birth outcomes in relation to metformin use during pregnancy from a clinical register. Read More

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http://doi.wiley.com/10.1111/1753-0407.12905
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http://dx.doi.org/10.1111/1753-0407.12905DOI Listing
January 2019
9 Reads

Serum apolipoprotein B is associated with increased risk of metabolic syndrome among middle-aged and elderly Chinese: A cross-sectional and prospective cohort study.

J Diabetes 2019 Jan 16. Epub 2019 Jan 16.

National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Serum apolipoprotein (apo) B has been associated with an increased risk of atherosclerotic cardiovascular diseases. However, findings on the association between apoB and the risk of metabolic syndrome (MetS) are inconsistent. The purpose of this study was to investigate the association between serum apoB and MetS risk in Chinese population. Read More

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http://dx.doi.org/10.1111/1753-0407.12904DOI Listing
January 2019
3 Reads

Neutrophil-lymphocyte ratio as a predictor of kidney function decline among individuals with diabetes and prediabetes: A 3-year follow-up study.

J Diabetes 2019 Jan 13. Epub 2019 Jan 13.

School of Medicine, Nankai University, Tianjin, China.

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http://dx.doi.org/10.1111/1753-0407.12903DOI Listing
January 2019
1 Read

Teriparatide (recombinant human parathyroid hormone [1-34]) increases foot bone remodeling in diabetic chronic Charcot neuroarthropathy: a randomized double-blind placebo-controlled study.

J Diabetes 2019 Jan 10. Epub 2019 Jan 10.

Department of Surgery, Keck School of Medicine, Los Angeles, California.

Background: Currently, there is no consensus regarding the medical treatment of chronic Charcot neuroarthropathy (CN) of foot, except for effective off-loading. Because tarsal bones are predominantly trabecular, teriparatide may improve the macroarchitecture of foot bones in chronic CN.

Methods: People with diabetes and chronic CN were randomized to receive either 20 μg teriparatide or placebo subcutaneous daily for 12 months. Read More

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http://dx.doi.org/10.1111/1753-0407.12902DOI Listing
January 2019
7 Reads

World Congress on Clinical Trials in Diabetes 2018.

J Diabetes 2019 May 22;11(5):342-344. Epub 2019 Feb 22.

Close Concerns, San Francisco, California.

Martin J. Kurian, Peter J. Rentzepis, Ann M. Read More

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http://dx.doi.org/10.1111/1753-0407.12901DOI Listing
May 2019
1 Read

Associations between metformin use and vitamin B levels, anemia, and neuropathy in patients with diabetes: a meta-analysis.

J Diabetes 2019 Jan 7. Epub 2019 Jan 7.

Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.

Background: Metformin is first-line therapy for patients with diabetes. However, it may lower vitamin B concentrations, which could have hematological or neurological implications. This meta-analyses reviewed all available studies on associations between metformin use and vitamin B levels, anemia, and neuropathy in diabetic patients. Read More

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http://doi.wiley.com/10.1111/1753-0407.12900
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http://dx.doi.org/10.1111/1753-0407.12900DOI Listing
January 2019
17 Reads

Diverse human leukocyte antigen association of type 1 diabetes in north India.

J Diabetes 2019 Jan 7. Epub 2019 Jan 7.

Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India.

Background: Type 1 diabetes (T1D) is a complex disease, with involvement of various susceptibility genes. Human leukocyte antigen (HLA) on chromosome 6p21 is major susceptibility region. This study examined genetic association of HLA genes with T1D. Read More

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http://doi.wiley.com/10.1111/1753-0407.12898
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http://dx.doi.org/10.1111/1753-0407.12898DOI Listing
January 2019
14 Reads

Joint effects of folate and vitamin B imbalance with maternal characteristics on gestational diabetes mellitus.

J Diabetes 2019 Jan 7. Epub 2019 Jan 7.

Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China.

Background: This study examined whether folate and vitamin B imbalance is associated with gestational diabetes mellitus (GDM) and explored interactions between B vitamin imbalance and maternal risk factors for GDM.

Methods: A cross-sectional study was performed in 406 Chinese pregnant women. Serum folate, vitamin B , and blood glucose concentrations were measured at 24 to 28 weeks gestation during GDM screening. Read More

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http://dx.doi.org/10.1111/1753-0407.12899DOI Listing
January 2019
9 Reads

Fournier's gangrene in a patient on dapagliflozin treatment for type 2 diabetes.

J Diabetes 2019 May 5;11(5):348-350. Epub 2019 Feb 5.

Department of Endocrinology, Ankara Training and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1111/1753-0407.12896DOI Listing
May 2019
3 Reads

Fournier's gangrene and sodium-glucose cotransporter 2 inhibitors: Is there a causal association?

J Diabetes 2019 May 3;11(5):340-341. Epub 2019 Feb 3.

Metabolic Institute of America, Los Angeles, CA.

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http://dx.doi.org/10.1111/1753-0407.12897DOI Listing
May 2019
5 Reads

Detecting pioglitazone use and risk of cardiovascular events using electronic health record data in a large cohort of Chinese patients with type 2 diabetes.

J Diabetes 2018 Dec 30. Epub 2018 Dec 30.

Institute of Medical Informatics and Management, Nanjing Medical University, Nanjing, China.

Background: Pioglitazone may have a protective effect against cardiovascular disease risk among type 2 diabetes (T2D) patients, but evidence from China is lacking. This study investigated the association using electronic health records (EHR) data from a Chinese cohort of T2D patients.

Methods: All T2D patients from the First Affiliated Hospital of Nanjing Medical University who were prescribed at least one oral antidiabetic drug and were aged ≥18 years between 1 July 2005 and 30 June 2017 were eligible for inclusion (n = 71 783). Read More

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http://dx.doi.org/10.1111/1753-0407.12894DOI Listing
December 2018
8 Reads

Dipeptidyl peptidase-4 inhibitors attenuate thyroid-stimulating hormone concentrations.

J Diabetes 2018 Dec 30. Epub 2018 Dec 30.

Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan.

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http://dx.doi.org/10.1111/1753-0407.12895DOI Listing
December 2018
1 Read

Effect of diabetes mellitus on the recovery of changes in renal functions and glomerular permeability following reversible 24-hour unilateral ureteral obstruction.

J Diabetes 2018 Dec 28. Epub 2018 Dec 28.

Department of Surgery, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

Background: Following reversal of short periods of ureteral obstruction (UO), glomerular and tubular renal dysfunction recovers with time. Diabetes mellitus (DM) affects glomerular function; thus, the ability of diabetic kidneys to recover from UO may be impaired. This study investigated the effects of long-term DM on the recovery of glomerular and tubular function, as well as permeability of the glomerular filtration barrier (GFB), after unilateral UO (UUO) reversal. Read More

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http://dx.doi.org/10.1111/1753-0407.12893DOI Listing
December 2018
1 Read

Increased formation of neutrophil extracellular traps is associated with gut leakage in patients with type 1 but not type 2 diabetes.

J Diabetes 2018 Dec 28. Epub 2018 Dec 28.

Minigene Pharmacy Laboratory, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.

Background: The aim of this study was to investigate the association of the formation of neutrophil extracellular traps (NETs) with gut leakage in type 1 (T1D) and type 2 diabetes (T2D).

Methods: In all, 105 subjects (56 T1D, 49 T2D) were included in the study. Eight biomarkers of NET formation and gut leakage (ie, protein arginine deiminase type 4 [PAD4], neutrophil elastase [NE], proteinase 3 [PR3], complement 5a [C5a], α -antitrypsin [AAT], DNase I, zonulin, and lipopolysaccharide [LPS]) were measured in serum samples by ELISA. Read More

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http://doi.wiley.com/10.1111/1753-0407.12892
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http://dx.doi.org/10.1111/1753-0407.12892DOI Listing
December 2018
13 Reads

Effect of liraglutide on the Janus kinase/signal transducer and transcription activator (JAK/STAT) pathway in diabetic kidney disease in db/db mice and in cultured endothelial cells.

J Diabetes 2018 Dec 21. Epub 2018 Dec 21.

Nephrology Laboratory, Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba, Israel.

Background: Emerging evidence demonstrates the involvement of Janus tyrosine kinase/signal transducer and transcription activator (JAK/STAT) proteins in the pathophysiology of diabetic kidney disease (DKD). The JAK/STAT pathway is involved in the inflammatory response and endothelial cell dysfunction observed in DKD. The glucagon-like peptide-1 (GLP-1) analog liraglutide is an effective treatment for type 2 diabetes because it improves the inflammatory changes observed in experimental models of DKD. Read More

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http://dx.doi.org/10.1111/1753-0407.12891DOI Listing
December 2018
1 Read

Systematic review of sociodemographic representation and cultural responsiveness in psychosocial and behavioral interventions with adolescents with type 1 diabetes.

Authors:
Jennifer Morone

J Diabetes 2018 Dec 18. Epub 2018 Dec 18.

School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: The increasing incidence of type 1 diabetes (T1D) in youth aged less than 20 years in the USA is a mounting public health concern. Specific sociodemographic characteristics-racial/ethnic minority, low socioeconomic status (SES), single-parent home and underinsured-have been associated with increased risk for poor glycemic control and poor self-management in adolescents with T1D.

Methods: Sample demographic and cultural responsiveness methods in psychosocial and behavioral interventions focused on improving self-management and glycemic control in adolescents with T1D were systematically evaluated, to identify if studies were targeting these high-risk groups. Read More

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http://dx.doi.org/10.1111/1753-0407.12889DOI Listing
December 2018
1 Read

Safety and efficacy of sodium glucose co-transporter 2 inhibitors combined with insulin in adults with type 1 diabetes: A meta-analysis of randomized controlled trials.

Authors:
Kexin Li Gaosi Xu

J Diabetes 2018 Dec 18. Epub 2018 Dec 18.

Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Jiangxi, China.

Background: The safety and efficacy of sodium glucose co-transporter 2 (SGLT2) inhibitors in a dose-dependent manner for type 1 diabetes mellitus (T1DM) are unclear.

Methods: Randomized clinical trials (RCT) were searched from PubMed, EMBASE, the Cochrane Library, Web of Science and ClinicalTrials until August 2018.

Results: Thirteen RCT with 5397 participants were included. Read More

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http://dx.doi.org/10.1111/1753-0407.12890DOI Listing
December 2018
1 Read

Notes from the world congress on insulin resistance, diabetes, and cardiovascular disease.

J Diabetes 2019 Apr 3;11(4):258-260. Epub 2019 Jan 3.

Metabolic Institute of America, Tarzana, California.

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http://dx.doi.org/10.1111/1753-0407.12888DOI Listing
April 2019
1 Read

Trends in medication utilization, glycemic control and outcomes among type 2 diabetes patients in a tertiary referral center in Singapore from 2007 to 2017.

J Diabetes 2018 Dec 16. Epub 2018 Dec 16.

Department of Rheumatology and Immunology, Singapore General Hospital, Singapore.

Background: Use of glucose-lowering agents is a cornerstone in combating type 2 diabetes (T2DM). Treatment guidelines have changed significantly over the past decade. We report temporal trends in medication utilization, glycemic control and rate of severe hypoglycemia in T2DM patients at a tertiary referral center in Singapore. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1753-0407.12
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http://dx.doi.org/10.1111/1753-0407.12886DOI Listing
December 2018
15 Reads

Higher blood pressure predicts diabetes and enhances long-term risk of cardiovascular disease events in individuals with impaired glucose tolerance: Twenty-three-year follow-up of the Daqing diabetes prevention study.

J Diabetes 2018 Dec 16. Epub 2018 Dec 16.

Center of Endocrinology and Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: Hypertension is more prevalent in subjects with impaired glucose tolerance (IGT), but whether higher blood pressure per se or the mild hyperglycemia in combination with the hypertension enhanced the risk of cardiovascular disease (CVD) remains unclear.

Methods: Five hundred and sixty-eight participants with IGT in the original Daqing diabetes prevention study, 297 with hypertension (HBP) and 271 without hypertension (NBP), were enrolled in 1986 and the intervention phase lasted for 6 years. In 2009, they were followed up to assess the outcomes of cardiovascular events (including stroke and myocardial infarction) and incidence of diabetes. Read More

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http://dx.doi.org/10.1111/1753-0407.12887DOI Listing
December 2018
8 Reads

Protracted glycosuria after discontinuation of sodium-glucose cotransporter 2 inhibitors: Implications for weekly dosing and extended risk of euglycemic diabetes ketoacidosis.

J Diabetes 2019 May 3;11(5):410-411. Epub 2019 Jan 3.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, College of Medicine and Life Sciences, University of Toledo, Toledo, Ohio.

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http://dx.doi.org/10.1111/1753-0407.12885DOI Listing
May 2019
2 Reads

American Heart Association Scientific Sessions 2018.

J Diabetes 2019 Apr 6;11(4):261-264. Epub 2019 Jan 6.

Close Concerns, San Francisco, California.

Martin J. Kurian, Peter J. Rentzepis, Ann M. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1753-0407.12
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http://dx.doi.org/10.1111/1753-0407.12884DOI Listing
April 2019
20 Reads

Role of metabolic syndrome and its components as mediators of the genetic effect on type 2 diabetes: A family-based study in China.

J Diabetes 2018 Dec 5. Epub 2018 Dec 5.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Background: Metabolic syndrome (MetS) share a genetic basis with type 2 diabetes (T2D). However, whether MetS and its components mediate genetic susceptibility to T2D is not completely understood.

Methods: We assessed the effects of MetS and its components on associations T2D and 18 genome-wide association studies-identified variants using a two-stage strategy based on parametric models involving 7110 Chinese participants (2436 were T2D patients) across 2885 families. Read More

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http://doi.wiley.com/10.1111/1753-0407.12882
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http://dx.doi.org/10.1111/1753-0407.12882DOI Listing
December 2018
15 Reads

Combined effect of GABA and glucagon-like peptide-1 receptor agonist on cytokine-induced apoptosis in pancreatic β-cell line and isolated human islets.

J Diabetes 2018 Dec 5. Epub 2018 Dec 5.

Division of Endocrinology and Metabolism, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Canada.

Background: Treatment with GABA or glucagon-like peptide-1 (GLP-1) can preserve pancreatic β-cell mass and prevent diabetes. Recently, we reported that the combination of GABA and sitagliptin (a dipeptidyl peptidase-4 inhibitor that increases endogenous GLP-1) was more effective than either agent alone in reducing drug-induced β-cell damage and promoting β-cell regeneration in mice. However, in human islets, it remains unclear whether GABA and GLP-1 exert similar effects. Read More

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http://dx.doi.org/10.1111/1753-0407.12881DOI Listing
December 2018
8 Reads

Effect of baseline body mass index on glycemic control and weight change with exenatide monotherapy in Chinese drug-naïve type 2 diabetic patients.

J Diabetes 2018 Dec 5. Epub 2018 Dec 5.

Key Laboratory of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Background: The weight-reducing effect of exenatide has been proved, but too much weight loss in normal-weight patients may concern physicians. This study evaluated the effects of exenatide monotherapy on glycemic control and weight change in normal-weight, overweight, and obese patients with newly diagnosed type 2 diabetes (T2D).

Methods: In this multicenter prospective study, 29 normal-weight, 54 overweight, and 27 obese newly diagnosed and drug-naïve patients with T2D were treated with exenatide for 48 weeks. Read More

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http://dx.doi.org/10.1111/1753-0407.12883DOI Listing
December 2018
10 Reads

Lipids as risk markers for type 2 diabetes.

J Diabetes 2019 Mar 18;11(3):176-178. Epub 2018 Dec 18.

Department of Medicine, University of Texas Health Science Center, San Antonio, Texas.

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http://dx.doi.org/10.1111/1753-0407.12880DOI Listing
March 2019
1 Read

Association of common type 1 and type 2 diabetes gene variants with latent autoimmune diabetes in adults: A meta-analysis.

J Diabetes 2018 Nov 19. Epub 2018 Nov 19.

Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.

Background: The aim of this meta-analysis was to determine the association of common type 1 diabetes (T1D) and type 2 diabetes (T2D) gene variants (protein tyrosine phosphatase non-receptor 22 [PTPN22] rs2476601C/T, insulin [INS] rs689A/T and transcription factor 7-like 2 [TCF7L2] rs7903146C/T) with latent autoimmune diabetes in adults (LADA).

Methods: A systematic search of electronic databases was conducted up to 2017 and data from 16 independent case-control studies for three gene variants were pooled. The pooled allele and genotype frequencies for each T1D and T2D gene variant were used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Read More

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http://dx.doi.org/10.1111/1753-0407.12879DOI Listing
November 2018
19 Reads

Endoscopic bariatric and metabolic therapies: Another tool for the management of diabetes and obesity.

J Diabetes 2019 May 3;11(5):351-358. Epub 2019 Jan 3.

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

Endoscopic bariatric and metabolic therapies (EBMTs) have sparked significant interest as minimally invasive therapeutic options for weight loss. Although bariatric surgery remains an effective option for sustained weight loss and improvement in the metabolic syndrome, access and utilization are limited. Various EBMTs have been designed to emulate the physiologic effects of established surgical interventions, including space-occupying and non-space-occupying gastric therapies, gastric remodeling procedures, and small bowel therapies. Read More

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http://doi.wiley.com/10.1111/1753-0407.12878
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http://dx.doi.org/10.1111/1753-0407.12878DOI Listing
May 2019
15 Reads