1,804 results match your criteria Journal of Dermatological Treatment[Journal]


Lp- PLA2 as a promising predictor of comorbidities in patients with severe psoriasis.

J Dermatolog Treat 2019 Apr 18:1-27. Epub 2019 Apr 18.

a Department of Dermatology and Venereology Medical University of Bialystok , 15-540 Bialystok, Zurawia 14 St , Poland.

Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a well- known risk factor of atherosclerotic vascular diseases which are common comorbidities in psoriasis. The aim of this study was to evaluate serum Lp-PLA2 level in psoriatic patients and elucidate possible associations with disease activity, metabolic or inflammatory parameters and systemic treatment.

Methods: We enrolled 33 patients with active plaque-type psoriasis and 11 healthy controls. Read More

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http://dx.doi.org/10.1080/09546634.2019.1606887DOI Listing

A case of Generalized Pustular Psoriasis and arthritis treated with ixekizumab.

J Dermatolog Treat 2019 Apr 18:1-7. Epub 2019 Apr 18.

a Department of Dermatology , Univeristy of Rome "Tor Vergata" , Rome , Italy.

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http://dx.doi.org/10.1080/09546634.2019.1606395DOI Listing

Clinical assessment of topical erythromycin gel with and without zinc acetate for treating mild to moderate acne vulgaris.

J Dermatolog Treat 2019 Apr 18:1-23. Epub 2019 Apr 18.

b Department of Dermatology , School of Medicine, Shiraz University of Medical Sciences , Shiraz , Iran.

Erythromycin is an effective topical antibiotic for treating mild to moderate inflammatory acne vulgaris, especially papules acne during puberty as well as papules - pustular acne in adult women. Erythromycin is a macrolide antibiotic that has long been used as a topical dosage form to treat acne. It has favorable effects in resolving inflammatory acne lesions not only by reducing Propioni bacterium acnes density, but also by directly inhibiting neutrophil chemotactic factors and reactive oxygen species (ROS) production (1- 3). Read More

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http://dx.doi.org/10.1080/09546634.2019.1606394DOI Listing

Dry skin management: Practical approach in light of latest research on skin structure and function.

J Dermatolog Treat 2019 Apr 18:1-28. Epub 2019 Apr 18.

e Leiden Academic Centre for Drug Research, Division of Drug Delivery Technology , Leiden , PO box 9502, NL-2300 RA Leiden , The Netherlands.

Dry skin is a common condition that is attributed to a lack of water in the stratum corneum. With the availability of new technologies, light has been shed on the pathophysiology of dry skin at the molecular level. With the aim to discuss implications of this latest research for the optimal formulation of emollients designed to treat dry skin, five specialists met in November 2017. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1607024DOI Listing
April 2019
5 Reads

Clinical factors influencing the response to intravenous immunoglobulin treatment in cases of treatment-resistant pyoderma gangrenosum.

J Dermatolog Treat 2019 Apr 18:1-13. Epub 2019 Apr 18.

a Department of Dermatology , Oregon Health & Science University, Center for Health & Healing , 3303 SW Bond Ave. Portland , Oregon 97239 , USA.

Background: Pyoderma gangrenosum (PG) is a neutrophilic disorder which classically presents as chronic, painful ulcers on the lower extremities. There is evidence supporting a potential role for intravenous immunoglobulin (IVIG) as adjuvant therapy for treatment-resistant cases; however, it is unclear which patients will most benefit from this modality of treatment - an especially important consideration given the cost per infusion ($5,000-$10,000). Thus, we sought to identify the clinical characteristics of patients with refractory PG lesions who demonstrated complete healing when IVIG was incorporated into the therapeutic plan. Read More

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http://dx.doi.org/10.1080/09546634.2019.1606888DOI Listing

Tissue lipocalin-2 in psoriasis: Is it a marker of metabolic disturbance or a possible marker of therapeutic efficacy after narrow band ultraviolet B?

J Dermatolog Treat 2019 Apr 17:1-20. Epub 2019 Apr 17.

a Dermatology Department, Faculty of Medicine , Cairo University , Egypt.

Background: Lipocalin-2 (LCN2) is an adipokine related to insulin resistance and metabolic syndrome (MetS) in addition to its role in innate immunity and apoptosis.

Objective: To estimate LCN2 tissue levels (lesional and non-lesional) in psoriasis. To assess the metabolic status of patients and to detect any possible associations between LCN2 and MetS. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1605141DOI Listing
April 2019
2 Reads

Dead Sea Climatotherapy versus topical steroid treatment for Atopic Dermatitis children: long-term follow-up study.

J Dermatolog Treat 2019 Apr 17:1-19. Epub 2019 Apr 17.

c Dead Sea & Arava Science Center , Israel.

The aim of this study was to compare long-term results of 4 weeks Dead Sea Climatotherapy at the Deutsches Medizinisches Zentrum, Israel to those obtained by classical topical treatment for moderate-to-severe Atopic Dermatitis. Seventy-two children from the Czech Republic were divided into three groups of twenty-four and treated during 3 periods (March 2014, October 2014 and March 2015) with gradually increasing sun exposure during 28 consecutive days. Forty-four children were treated with steroid creams at the Department of Dermatovenereology, Third Faculty of Medicine, Charles University and University Hospital of Kralovske Vinohrady, Prague, Czech Republic. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605138DOI Listing

Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts.

J Dermatolog Treat 2019 Apr 16:1-20. Epub 2019 Apr 16.

a Shandong Provincial Institute of Dermatology and Venereology , Jinan , Shandong , China.

Background: Condylomata acuminata(CA) are a common sexually transmitted disease. The recurrence rate of condyloma acuminatum using traditional treatments is higher than that of applying photodynamic therapy, and a variety of adverse reactions after treatment. At the same time, different parts of condyloma acuminatum after treatment recurrence rate is also different, especially for intra anal-rectal warts. Read More

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http://dx.doi.org/10.1080/09546634.2019.1594670DOI Listing
April 2019
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Effectiveness of etanercept biosimilar SB4 in maintaining low disease activity in patients with psoriatic arthritis switched from etanercept originator: an open label one year study.

J Dermatolog Treat 2019 Apr 15:1-17. Epub 2019 Apr 15.

a Centre for the Study and Treatment of Psoriasis at the Department of Clinical Dermatology, San Gallicano Dermatological Institute, IRCCS , Via Elio Chianesi 53 , 00144 Rome , Italy.

Background: Currently, there are no studies specifically aimed at investigating the effectiveness of etanercept biosimilar SB4 in psoriatic arthritis (PsA).

Objectives: Our primary objective was to verify the ability of SB4 to maintain low disease activity in patients switching to SB4 after 1 year of treatment with the reference etanercept.

Methods: Eighty-seven PsA patients with low disease activity at baseline measured by using the clinical Disease Activity Index for Psoriatic Arthritis ≤13 (cDAPSA; range 0-154) were prospectively evaluated after 6 and 12 months when switching from the reference etanercept to SB4. Read More

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http://dx.doi.org/10.1080/09546634.2019.1606886DOI Listing
April 2019
1 Read

The Effects of Isotretinoin on Affective and Cognitive Functions are Disparate in Adolescent Acne Vulgaris Patients.

J Dermatolog Treat 2019 Apr 15:1-17. Epub 2019 Apr 15.

b Department of Child and Adolescent Psychiatry , Ankara University, School of Medicine , Ankara , Turkey.

Background: The vulnerable brain regions to isotretinoin are represented as hippocampus and prefrontal cortex, involved in mood regulation as well as coordination of cognitive functions. Adolescence is a critical period with dynamic alterations in neurocognition. Isotretinoin brought concerns about its possible effects on executive functions, attention and memory. Read More

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http://dx.doi.org/10.1080/09546634.2019.1606396DOI Listing

Successful Treatment of Ulcerated Infantile Hemangioma with Brimonidine-Timolol Cream: 2 Cases Report and Review of the Literature.

J Dermatolog Treat 2019 Apr 11:1-6. Epub 2019 Apr 11.

a Dermatology Department , Security Forces Hospital , Dammam , Saudi Arabia.

Ulceration is the most common complication of Infantile Hemangioma (IH). We reported 2 cases of ulcerated IH treated by new cream formulation of brimonidine 0.2%-timolol 0. Read More

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http://dx.doi.org/10.1080/09546634.2019.1603991DOI Listing
April 2019
1 Read

Superficial radiotherapy for non-melanoma skin cancer of the lip: a 44-year Italian experience.

J Dermatolog Treat 2019 Apr 11:1-17. Epub 2019 Apr 11.

a Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Sezione Fotoradioterapia , UO Dermatologia , Milan , Italy.

Background: Radiotherapy is a valuable therapeutic option for the treatment of non-melanoma skin cancer (NMSC) in the ageing population, in non-surgical candidates, or when the tumour is extensive or localised in a cosmetically-sensitive area such as the lips.

Objective: We report our 44-year experience in treating basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the vermilion lip using superficial radiotherapy.

Methods: Forty-seven patients with biopsy-proven BCC or SCC of the lip were retrospectively reviewed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605137DOI Listing
April 2019
5 Reads

Safety and efficacy of Certolizumab Pegol in a real-life cohort of patients with Psoriasis and Psoriatic Arthritis.

J Dermatolog Treat 2019 Apr 9:1-20. Epub 2019 Apr 9.

d Dermatology Department, Department of Biotechnological and Applied Clinical Science , School of Medicine, University of L'Aquila , Italy.

Background: Aim of this observational study was to assess safety and efficacy of Certolizumab Pegol(CZP) in a real-life cohort of patients affected by psoriasis(PsO) and psoriatic arthritis(PsA), who had an inadequate response to previous systemic immunosuppressive treatments, with a follow-up of 24 weeks.

Materials And Methods: Twelve patients with PsO and PsA, referring to our Dermatology/Rheumatology combined outpatient clinic, were enrolled.Primary endpoints were safety and efficacy of CZP, defined as statistically significant improvement of DAPSA, clinical DAPSA and PASI. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605143DOI Listing
April 2019
1 Read

A cross-sectional study of YouTube videos as a source of patient information about phototherapy and excimer laser for psoriasis.

J Dermatolog Treat 2019 Apr 9:1-15. Epub 2019 Apr 9.

d Dermatology Research and Education Foundation , Irvine , CA.

YouTube is increasingly utilized by patients for health information. We aimed to assess the educational quality of YouTube videos about phototherapy and excimer laser for psoriasis. A cross-sectional analysis of YouTube videos was conducted using the search terms psoriasis phototherapy and psoriasis laser. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605144DOI Listing

Ustekinumab treatment for moderate to severe psoriasis. Eight-year real-world follow-up of 61 cases in a tertiary level hospital.

J Dermatolog Treat 2019 Apr 8:1-20. Epub 2019 Apr 8.

b Department of Dermatology , Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Instituto de Investigación Biomédica de A Coruña (INIBIC), Universidade da Coruña (UDC) , Spain.

Background Efficacy and safety profiles of ustekinumab have been proved in numerous clinical trials. However, relevant variations with daily practice have been shown, and few studies value the long-term response maintenance. Objective To evaluate the efficacy of long-term ustekinumab therapy in patients with moderate-to-severe plaque-type psoriasis in a real-world setting. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605140DOI Listing

Long-term effects of biologic therapies on peripheral blood eosinophils in patients with psoriasis: A 3-year single-centre study.

J Dermatolog Treat 2019 Apr 8:1-20. Epub 2019 Apr 8.

a Department of Dermatology and Venereology , Hacettepe University, School of Medicine , Ankara , Turkey.

Background: Biologic therapies (BTs),etanercept, infliximab, adalimumab, ustekinumab, are generally well-tolerated and safe agents in psoriasis management.

Objectives: To determine the overall effect of BTs on peripheral blood eosinophil count(PBEc) and percentage(PBEp), peripheral blood basophil count(PBBc) and percentage(PBBp), white blood cell count(WBCc),erythrocyte sedimentation rate(ESR),and serum C-reactive protein(s-CRP) level during a 3-year follow-up in patients with psoriasis.

Methods: This retrospective cohort study included 200 patients(116 men;84 women) treated continuously with BTs for 3 years for plaque-type, pustular, or nail psoriasis. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605139DOI Listing
April 2019
1 Read

Efficacy of Bleomycin Application on Periungual Warts after Treatment with Ablative Carbon Dioxide Fractional Laser: A Pilot Study.

J Dermatolog Treat 2019 Apr 8:1-22. Epub 2019 Apr 8.

a Department of Dermatology , Sanggye Paik Hospital, Inje University College of Medicine , Seoul , Republic of Korea.

Background: Treating periungual warts is a therapeutic challenge. Treatments are often ineffective and may cause complications including permanent nail changes, pain, and scaring. Translesional bleomycin delivery via the multipuncture technique is now reported. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1605136DOI Listing
April 2019
2 Reads

Association of lymphopenia and eosinophilia with dimethylfumarate treatment efficacy and tolerability in psoriasis: A retrospective study.

J Dermatolog Treat 2019 Apr 8:1-14. Epub 2019 Apr 8.

a Department of Dermatology , Máxima Medical Center Veldhoven , De Run 4600, P.O.Box 7777, 5500 MB , Veldhoven , The Netherlands.

Background Dimethylfumarate (DMF) is an effective treatment for psoriasis, which may cause side effects in a considerable group of patients. Alterations in white blood cell counts (WBC) may predict treatment success and the occurrence of side effects. Objectives To analyze WBC counts with respect to efficacy and the prevalence of side effects during DMF therapy for psoriasis. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605135DOI Listing

Drug survival of guselkumab for psoriasis in a real-world setting: a single-center retrospective chart review.

J Dermatolog Treat 2019 Apr 8:1-7. Epub 2019 Apr 8.

e Dermatology Research and Education Foundation , Irvine , CA , USA.

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http://dx.doi.org/10.1080/09546634.2019.1605133DOI Listing
April 2019
1 Read

Reconstruction of nasal supratip defect using vertical alar groove tissue.

J Dermatolog Treat 2019 Apr 8:1-13. Epub 2019 Apr 8.

a Department of Dermatology , Seoul National University College of Medicine, Bundang Hospital , Gyeonggi , Korea.

Abstracts Background: Several local flaps have been introduced for the reconstruction of small-to-medium-sized nasal supratip defects.

Objective: To evaluate the outcome of reconstructing supratip defects using tangential advancement flaps from the vertical alar groove tissue.

Methods & Materials: Medical records of 20 patients who underwent supratip reconstruction using this flap between January 2012 and July 2018 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605134DOI Listing

The contradictory inefficacy of methotrexate in hidradenitis suppurativa: a need to revise pathogenesis or acknowledge disease heterogeneity?

Authors:
John W Frew

J Dermatolog Treat 2019 Apr 4:1-2. Epub 2019 Apr 4.

a Laboratory of Investigative Dermatology , Rockefeller University , New York , NY , USA.

The pathogenesis of hidradenitis suppurativa (HS) centers around Th17/Treg dysfunction illustrated by lesional elevation of IL-17A, IL-6, and other inflammatory mediators resulting in a chronic feed-forward inflammatory cascade. Similar inflammatory mechanisms have been identified in psoriasis and rheumatoid arthritis (RA) in which traditional immunosuppressants (including methotrexate) are routinely used with reasonable levels of disease control. Methotrexate's mechanism of action in these instances includes downregulation of the Th17 axis via alterations in dendritic cell and T-cell activity and maturation. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1601668DOI Listing
April 2019
2 Reads

Notalgia Paresthetica: Treatment Review and Algorithmic Approach.

J Dermatolog Treat 2019 Apr 3:1-27. Epub 2019 Apr 3.

a University of Central Florida College of Medicine , 6850 Lake Nona Blvd , Orlando , FL USA 32827.

Background: Notalgia Paresthetica (NP) is a sensory neuropathy of the back characterized by a well-demarcated, hyperpigmented macule or patch located medial or inferior to the scapulae. Symptoms include localized pruritus and pain, and the clinical course consists of remissions and relapses. It can be an underrecognized and difficult disease to treat since conventional treatments for pruritus in inflammatory dermatosis have variable efficacy. Read More

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http://dx.doi.org/10.1080/09546634.2019.1603360DOI Listing
April 2019
7 Reads

Off-label studies on apremilast in dermatology: a review.

J Dermatolog Treat 2019 Apr 2:1-10. Epub 2019 Apr 2.

a Division of Dermatology, Department of Medicine , David Geffen School of Medicine at UCLA , Los Angeles , CA , USA.

Purpose: Apremilast is a phosphodiesterase-4 inhibitor FDA approved for psoriatic arthritis and moderate to severe plaque psoriasis. In recent years, multiple studies have suggested other potential uses for apremilast in dermatology. A summary of these various studies will be a valuable aid to dermatologists considering apremilast for an alternative indication. Read More

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http://dx.doi.org/10.1080/09546634.2019.1589641DOI Listing
April 2019
5 Reads

Can we consider silymarin as a treatment option for vitiligo? A double-blind controlled randomized clinical trial of phototherapy plus oral Silybum marianum product versus phototherapy alone.

J Dermatolog Treat 2019 Apr 2:1-5. Epub 2019 Apr 2.

a Molecular Dermatology Research Center, Shiraz University of Medical Sciences , Shiraz , Iran.

Introduction: Vitiligo is a chronic skin disorder caused by destruction of the skin melanocytes, which presents as a depigmented area in the skin. This study examined the effect of Phototherapy plus oral Silybummarianum on the treatment of skin lesions of Vitiligo.

Materials And Methods: In this randomized controlled clinical trial, 34 patients with vitiligo who were referred to Dermatology Clinic of Shahid Faghihi Hospital, Shiraz, Iran, were randomly divided into two groups. Read More

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http://dx.doi.org/10.1080/09546634.2019.1595506DOI Listing
April 2019
3 Reads

Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris: assessment of safety and tolerability in subgroups.

J Dermatolog Treat 2019 Apr 2:1-8. Epub 2019 Apr 2.

e Bausch Health Americas, Inc , Petaluma , CA , USA.

Background: Topical tretinoin's role in acne has been established through evidence-based guidelines. Cutaneous irritation and potential to cause or exacerbate postinflammatory hyperpigmentation (PIH) may limit use.

Objective: Evaluate safety and tolerability of novel polymeric formulation of tretinoin 0. Read More

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http://dx.doi.org/10.1080/09546634.2019.1587884DOI Listing
April 2019
4 Reads

Patients opinion and adherence to antimalarials in lupus erythematosus and rheumatoid arthritis treatment.

J Dermatolog Treat 2019 Apr 2:1-6. Epub 2019 Apr 2.

d Dermatology, School of Medical Sciences , State University of Rio de Janeiro (FCM/UERJ) , Rio de Janeiro , Brazil.

Objective: To obtain the opinion of patients with rheumatoid arthritis or lupus erythematosus about the use of antimalarials through questionnaires and to evaluate their adherence to medication.

Methods: A cross-sectional study of patients treated with antimalarial medication for a period equal to or longer than 1 year attended between November 2012 and October 2014. A structured questionnaire with 12 questions was filled out. Read More

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http://dx.doi.org/10.1080/09546634.2019.1595504DOI Listing
April 2019
2 Reads

The use of phosphodiesterase inhibitors for the treatment of alopecia.

J Dermatolog Treat 2019 Apr 2:1-8. Epub 2019 Apr 2.

a Department of Dermatology , University of California Irvine, Irvine , CA , USA.

Background: Hair loss encompasses a group of scarring and nonscarring diseases with limited treatment options. Understanding the pathogenesis of alopecias has led to the experimental use of phosphodiesterase inhibitors (PDEi).

Objective: To perform a systematic review of literature surrounding the use of PDEi for alopecia. Read More

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http://dx.doi.org/10.1080/09546634.2019.1592097DOI Listing
April 2019
5 Reads

Improved effectiveness from individualized dosing of self-administered biologics for the treatment of moderate-to-severe psoriasis: a 5-year retrospective chart review from a Spanish University Hospital.

J Dermatolog Treat 2019 Mar 29:1-8. Epub 2019 Mar 29.

d Department of Dermatology , University Hospital La Plana , Castellón , Spain.

Background: Biologics for moderate-to-severe psoriasis are expensive and treatment substitutions may vastly increase cost. Moreover, administration regimens in routine practice may differ from recommended guidelines.

Objectives: To evaluate long-term effectiveness, regimen, drug-survival, and efficiency of self-administered biologics in clinical practice. Read More

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http://dx.doi.org/10.1080/09546634.2019.1602246DOI Listing
March 2019
1 Read

Choice Overload in Systemic Psoriasis Therapy.

J Dermatolog Treat 2019 Mar;30(2):103-104

b Department of Pathology , Wake Forest School of Medicine , Winston-Salem , North Carolina.

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http://dx.doi.org/10.1080/09546634.2019.1582896DOI Listing
March 2019
1 Read

Correction.

Authors:

J Dermatolog Treat 2019 Mar 25. Epub 2019 Mar 25.

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http://dx.doi.org/10.1080/09546634.2019.1595391DOI Listing
March 2019
2 Reads

Risk of herpes zoster with IL-17 inhibitor therapy for psoriasis and other inflammatory conditions.

J Dermatolog Treat 2019 Mar 22:1-7. Epub 2019 Mar 22.

d Dermatology Research and Education Foundation , Irvine , CA , USA.

Background: Psoriasis is a chronic inflammatory skin disease that has been associated with a significantly higher risk of herpes zoster (HZ). Several newer biologics such as secukinumab, ixekizumab, and brodalumab inhibit IL-17 and have been highly effective for treatment of psoriasis. However, adverse events related to the immunosuppressive properties of these biologics have been observed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1597246DOI Listing
March 2019
2 Reads

The real world impact of adalimumab on quality of life and the physical and psychological effects of moderate-to-severe psoriasis: a UK prospective, multicenter, observational study.

J Dermatolog Treat 2019 Mar 21:1-34. Epub 2019 Mar 21.

i Department of Dermatology , Barts Health NHS Trust (Whipps Cross and Royal London Hospitals) , London , UK.

Psoriasis can adversely affect quality of life (QoL) and emotional well-being. In this UK prospective observational study we evaluated the 'real-world' impact of adalimumab on QoL and the physical/psychological effects of moderate-to-severe psoriasis. 143 biologic-naïve patients with moderate-to-severe psoriasis, receiving adalimumab in clinical practice, were included. Read More

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http://dx.doi.org/10.1080/09546634.2019.1592096DOI Listing
March 2019
5 Reads
1.764 Impact Factor

Paclitaxel as first- or second-line treatment for HIV-negative Kaposi's sarcoma: a retrospective study of 58 patients.

J Dermatolog Treat 2019 Mar 21:1-3. Epub 2019 Mar 21.

a Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Universitá degli Studi di Milano, U.O. Dermatologia, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milano, Italy.

Background: Paclitaxel has recently been approved for AIDS-related Kaposi's sarcoma (KS) and there is much interest also in HIV-negative KS.

Objective: To assess the safety and effectiveness of intravenous paclitaxel in the treatment of non-HIV-associated KS.

Method: A retrospective database analysis of our departmental database in histologically proven, HIV-negative KS. Read More

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http://dx.doi.org/10.1080/09546634.2019.1590520DOI Listing

Patient experiences of using Chinese herbal medicine for psoriasis vulgaris and chronic urticaria: A qualitative study.

J Dermatolog Treat 2019 Mar 21:1-28. Epub 2019 Mar 21.

a China-Australia International Research Centre for Chinese Medicine, & School of Health and Biomedical Sciences, RMIT University , PO Box 71, Bundoora Campus , Melbourne , VIC 3083 , Australia.

Background: Psoriasis vulgaris and chronic urticaria are common skin conditions with a significant health burden. Achieving long-term control remains a challenge, and some patients choose Chinese herbal medicine (CHM) to meet this need. Little is known about the motivators and experiences of using CHM for these skin conditions. Read More

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http://dx.doi.org/10.1080/09546634.2019.1591580DOI Listing
March 2019
2 Reads

Finasteride and androgenic alopecia; from therapeutic options to medical implications.

J Dermatolog Treat 2019 Mar 21:1-7. Epub 2019 Mar 21.

a Department of Dermatology , Carol Davila University , Bucharest , Romania.

Androgenic alopecia (AGA) is an esthetic condition with varying psycho-social implications, easily accepted by some patients and tolerated only with difficulty by others. Modern therapeutic options such as 5α-reductase inhibitors have significant outcomes, but also exert significant side effects in a subset of patients. The literature describes three distinct situations regarding finasteride administration, a compound largely used for AGA. Read More

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http://dx.doi.org/10.1080/09546634.2019.1595507DOI Listing
March 2019
4 Reads

Aloe polysaccharide protects skin cells from UVB irradiation through Keap1/Nrf2/ARE signal pathway.

J Dermatolog Treat 2019 Mar 21:1-9. Epub 2019 Mar 21.

b Department of Anorectal Surgery , Guang'anmen Hospital of Chinese Academy of Chinese Medical Sciences, Beijing, China.

The aim of this study was to investigate if aloe polysaccharide (AP) has the repairing effect on ultraviolet b (UVB) injured nerve cells. The study applied BALB/c female mice as animal model, and NFG-activated PC12 cells as cell model of skin nerve. The cell viability was detected by MTT assay, and cell apoptosis was detected by TUNEL (TdT-mediated dUTP nick-end labeling) and Annexin-V/PI assay, and cell-cycle status in different groups were observed via flow cytometry (FCM). Read More

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http://dx.doi.org/10.1080/09546634.2019.1591579DOI Listing
March 2019
2 Reads

Metformin use in hidradenitis suppurativa.

J Dermatolog Treat 2019 Mar 20:1-3. Epub 2019 Mar 20.

a The Charles Centre, Department of Dermatology , St Vincent's University Hospital , Dublin , Ireland.

Background: Hidradenitis suppurativa (HS) is a chronic debilitating inflammatory disease, associated with metabolic syndrome, obesity and insulin resistance. Metformin, an oral hypoglycaemic agent, may play an important role in delaying or preventing the onset of diabetes and metabolic syndrome. Metformin has been reported as having efficacy in HS. Read More

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http://dx.doi.org/10.1080/09546634.2019.1592100DOI Listing
March 2019
5 Reads
1.764 Impact Factor

Real-world use of extracorporeal photopheresis for patients with cutaneous T-cell lymphoma in the United States: 2010-2015.

J Dermatolog Treat 2019 Mar 20:1-8. Epub 2019 Mar 20.

a Pharmerit International LP , Bethesda , MA , USA.

Introduction: The National Comprehensive Cancer Network and the European Organization for Research and Treatment of Cancer recommend extracorporeal photopheresis (ECP) as systemic therapy for cutaneous T-cell lymphoma (CTCL).

Objective: To investigate real-world use of ECP in CTCL patients in the US.

Methods: Data from the Truven MarketScan database (2010-2015) were used to create a cohort of CTCL patients receiving systemic treatment. Read More

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http://dx.doi.org/10.1080/09546634.2019.1587144DOI Listing
March 2019
3 Reads

A novel treatment for retronychia: Case Series.

J Dermatolog Treat 2019 Mar 20:1-5. Epub 2019 Mar 20.

a Section of Dermatology , University of Naples Federico II, Naples , Italy. via Sergio Pansini 5 , 80131 Naples , Italy.

The term retronychia describes the proximal ingrowth of the nail that occurs when the nail plate (NP) embeds backwards into the proximal nail fold (PNF). Proximal avulsion of the nail remains the treatment of choice however, permanent postsurgical nail dystrophy can occur. We report here a case series of retronychia treated through chemical avulsion with 50% urea and 10% salicylic acid in vaseline white petroleum, covered by occlusive dressing and kept for 1 week. Read More

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http://dx.doi.org/10.1080/09546634.2019.1592098DOI Listing

Long-term experience with radiotherapy for the treatment of non-melanoma skin cancer.

J Dermatolog Treat 2019 Mar 20:1-6. Epub 2019 Mar 20.

c Department of Dermatology , Radboud University Medical Center , Nijmegen , Netherlands.

Purpose: In the Netherlands, the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin is increasing dramatically. Radiotherapy is one of the treatment options, especially for the high risk and the irradical excised tumours.

Methods: Retrospectively, the treatment outcome of all patients with BCC or SCC treated with radiotherapy in the period 2000-2013, were reviewed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1592099DOI Listing
March 2019
3 Reads

Assessing factors affecting sunscreen use and barriers to compliance: a cross-sectional survey-based study.

J Dermatolog Treat 2019 Mar 19:1-3. Epub 2019 Mar 19.

c Dermatology , University of Iowa Hospital and Clinics , Iowa City , IA , USA.

While sunscreen is effective prevention for skin cancer, public sunscreen use and compliance are low. Identifying factors affecting sunscreen use and barriers to compliance are important to understand in order to increase sunscreen use, especially among high-risk individuals. We conducted a single institution survey of 429 dermatology clinic patients to better understand patients' barriers to sunscreen use. Read More

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http://dx.doi.org/10.1080/09546634.2019.1587147DOI Listing
March 2019
1 Read

Effectiveness of subcision using carboxytherapy plus fractional carbon dioxide laser resurfacing in the treatment of atrophic acne scars: comparative split face study.

J Dermatolog Treat 2019 Mar 19:1-4. Epub 2019 Mar 19.

a Department of Dermatology and Venereology, Faculty of Medicine , Al-Azhar University , Cairo , Egypt.

Introduction: Fractional carbon dioxide laser resurfacing is the gold standard treatment for atrophic acne scars but when combined with subcision to the depressed scars it provides rapid improvement. Carboxytherapy is considered a tool for subcision via injecting the gas under pressure plus its well-known effect in rejuvenating scars.

Aim: Main objective of the work is to evaluate the effectiveness of combined subcision using carboxytherapy plus fractional carbon dioxide laser resurfacing in the treatment of atrophic acne scars. Read More

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http://dx.doi.org/10.1080/09546634.2019.1595505DOI Listing
March 2019
1 Read

Drug survival of conventional systemic and biologic therapies for moderate-to-severe psoriasis in clinical practice in Spain: prospective results from the SAHARA study.

J Dermatolog Treat 2019 Mar 19:1-24. Epub 2019 Mar 19.

d Janssen Medical Department , Madrid , Spain.

Background: A better understanding of determinants for drug survival of anti-psoriatic agents may guide dermatologists in the right therapeutic choice.

Objectives: To describe 2-year drug survival of conventional and biologic antipsoriatic treatments.

Methods: SAHARA was a prospective study in patients with moderate-to severe psoriasis who initiated a conventional or biologic drug. Read More

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http://dx.doi.org/10.1080/09546634.2019.1597244DOI Listing
March 2019
2 Reads

Efficacy and safety of guselkumab, administered with a novel patient-controlled injector (One-Press), for moderate-to-severe psoriasis: results from the phase 3 ORION study.

J Dermatolog Treat 2019 Mar 19:1-8. Epub 2019 Mar 19.

g Department of Dermatology, Venereology and Allergology , Wroclaw Medical University , Wrocław , Poland.

Objectives: Guselkumab, an interleukin-23 antagonist, is approved for self-administration with the UltraSafe Plus™ syringe to treat moderate-to-severe plaque-type psoriasis. We evaluated the efficacy, safety, pharmacokinetics, and acceptability of guselkumab administered using a novel patient-controlled injector (One-Press) in psoriasis patients.

Materials And Methods: This Phase 3, multicentre, double-blind, placebo-controlled study (ORION, Clinicaltrials. Read More

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http://dx.doi.org/10.1080/09546634.2019.1587145DOI Listing
March 2019
5 Reads

A cross-sectional study of YouTube videos as a source of patient information about topical psoriasis therapies.

J Dermatolog Treat 2019 Mar 18:1-4. Epub 2019 Mar 18.

d Dermatology Research and Education Foundation , Irvine , CA , USA.

YouTube is becoming an increasingly popular resource for patients seeking knowledge regarding treatment options for dermatologic conditions. This study assessed the quality of content on YouTube regarding topical treatment for psoriasis. A cross-sectional analysis of YouTube videos was conducted using search terms related to psoriasis topical therapies. Read More

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http://dx.doi.org/10.1080/09546634.2019.1597247DOI Listing

Effectiveness and safety of ustekinumab 90 mg in patients weighing 100 kg or less: a retrospective, observational, multicenter study.

J Dermatolog Treat 2019 Mar 18:1-5. Epub 2019 Mar 18.

a Department of Dermatology , Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB) , Badalona , Spain.

Background: Scant information from clinical practice is available on the effectiveness and safety of ustekinumab (UST) 90 mg in patients with psoriasis weighing 100 kg or less.

Objectives: To assess the effectiveness and safety at weeks 16 and 24 of UST 90 mg in patients with psoriasis weighing ≤100 kg, and to study the impact on clinical outcomes of body mass index (BMI) and prior exposure to UST 45 mg.

Methods: A retrospective, observational, and multicenter study of 74 adult patients who were treated with UST 90 mg at least 24 weeks. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1597245DOI Listing
March 2019
6 Reads
1.764 Impact Factor

A patient with squamous cell carcinoma in-situ successfully treated with intralesional 5-Fluorouracil and topical trichloroacetic acid.

J Dermatolog Treat 2019 Mar 7:1-3. Epub 2019 Mar 7.

a Department of Dermatology , Wertheim College of Medicine, Florida International University , Miami , FL , USA.

Background: The current gold standard and the first line of treatment for non-melanoma skin cancer is surgical excision. Nevertheless, some patients are not good candidates for surgery when wound healing may be impaired.

Methods: A 96-year-old male presented with 1. Read More

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http://dx.doi.org/10.1080/09546634.2019.1589642DOI Listing
March 2019
1 Read

Iontophoretic delivery of lidocaine hydrochloride through ex-vivo human skin.

J Dermatolog Treat 2019 Mar 7:1-9. Epub 2019 Mar 7.

b Centre for Biomedical Engineering, Indian Institute of Technology-Delhi , New-Delhi , India.

Background: Iontophoresis is one of the widely used noninvasive and painless transdermal drug delivery technique.

Objective: Transdermal delivery of Lidocaine Hydrochloride using continuous and modulated iontophoresis were evaluated across human skin ex-vivo and further assessed for skin tolerance in-vivo in the Swiss albino mice.

Methods: Continuous DC was modified into modulated DC by introducing ON-OFF time in continuous DC. Read More

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http://dx.doi.org/10.1080/09546634.2019.1589640DOI Listing
March 2019
2 Reads
1.764 Impact Factor

Minimise the regular laboratory monitoring during the systemic isotretinoin treatment: data of 704 patients with acne vulgaris.

J Dermatolog Treat 2019 Mar 6:1-15. Epub 2019 Mar 6.

a Department of Dermatology , Ankara Numune Training and Research Hospital , Ankara , Turkey.

Backround: Despite extensive usage of systemic isotretinoin in patients with acne for many years, laboratory monitoring protocols for adverse effects depend on the centers and there is no standardized practice for frequency and type of laboratory testing. We aimed to decrease unnecessary monitoring and to standardize our general clinical practice of our department as well as to provide patient comfort and cost saving.

Material And Method: The medical charts of 704 acne patients treated with systemic isotretinoin were reviewed retrospectively. Read More

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http://dx.doi.org/10.1080/09546634.2019.1591578DOI Listing
March 2019
4 Reads

Efficacy of topical imiquimod 3.75% in the treatment of actinic keratosis of the scalp in immunosuppressed patients: our case series.

J Dermatolog Treat 2019 Mar 5:1-5. Epub 2019 Mar 5.

b Department of Health Science , University of Eastern Piedmont , Novara , Italy.

Background: Actinic keratoses (AK) represent common cutaneous lesions, appearing in 'Field cancerization areas' and potentially evolving toward invasive neoplasm. Immunosuppressed patients frequently develop numerous and aggressive AKs.

Aim: In this observational study, we report our experience with topical Imiquimod 3. Read More

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http://dx.doi.org/10.1080/09546634.2019.1590524DOI Listing