1,743 results match your criteria Journal of Dermatological Treatment[Journal]


Qualitative analysis and reproducibility assessment of the Scalp Itch Numeric Rating Scale among patients with moderate to severe plaque psoriasis of the scalp.

J Dermatolog Treat 2019 Feb 12:1-35. Epub 2019 Feb 12.

a Celgene Corporation , Summit , NJ.

Background: Pruritus is a prevalent and bothersome symptom of scalp psoriasis. Validated scales assessing scalp itch are needed to assess treatment efficacy.

Objective: To evaluate comprehensibility and reproducibility of the Scalp Itch Numeric Rating Scale (NRS), a novel scale being used in a phase 3 study of apremilast. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577546DOI Listing
February 2019

A Decade Retrospective Study of Light/Laser Devices in Treating Nasal Rosacea.

J Dermatolog Treat 2019 Feb 7:1-24. Epub 2019 Feb 7.

a Department of Dermatology , No.1 Hospital of China Medical University , Shenyang , China.

Background: Large-scale retrospective studies of light/laser in treating nasal rosacea were lacking.

Objective: The study was aimed to perform a decade retrospection of the patients with nasal rosacea who were treated with light/laser devices.

Methods: Methods: A study between 2008 and 2017 was performed retrospectively. Read More

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http://dx.doi.org/10.1080/09546634.2019.1580669DOI Listing
February 2019
2 Reads

Lymphoprolipherative skin reactions induced by anti-TNFα: An open question.

J Dermatolog Treat 2019 Feb 6:1-14. Epub 2019 Feb 6.

a 1st Department of Dermatology "Andreas Syggros" Hospital, Medical School, National and Kapodistrian University of Athens , Athens , Greece.

Although anti-TNFα agents have revolutionized the treatment of many inflammatory diseases, various concerns have been reported regarding the risks of cancer development, as well as acceleration of the progression of subclinical, pre-existing malignancies. In this case series we investigated the provocative effect of anti-TNFα drugs in the development of cutaneous mycosis fungoides (MF)-like lymphoproliferative reactions. We describe 5 patients aged between 25-63 diagnosed with autoimmune disorders (psoriatic arthritis- one patient, Crohn's disease- one patient and ankylosing spondylitis- three patients) who received anti-TNFα agents before the development of a cutaneous lymphoproliferative reaction. Read More

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http://dx.doi.org/10.1080/09546634.2019.1579889DOI Listing
February 2019
1 Read

Is there an association between isotretinoin therapy and adverse mood changes? A prospective study in a cohort of acne patients.

J Dermatolog Treat 2019 Feb 5:1-6. Epub 2019 Feb 5.

c Kinghorn Dermatology Unit , Royal United Hospital , Bath , UK.

Background: Treatment with isotretinoin has been associated with adverse mood changes. However, even though a number of studies support this association, others refute it, and a concrete causal link has yet to be proven. Acne itself is associated with depressive symptoms, thus making studies on the topic difficult to design and interpret. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577545DOI Listing
February 2019

Studying the efficacy of a new radical treatment for acne vulgaris using a surgical technique.

J Dermatolog Treat 2019 Feb 1:1-21. Epub 2019 Feb 1.

b Department of Plastic Reconstructive Surgery , Yamate Clinic , Kiguchi Bldg. 5F, 1-4-4 Sannomiyacho, Chuo-ku , Kobe-shi , Hyogo 650-0021 , Japan.

Background: Despite the numerous treatments available for acne vulgaris, not all are efficacious, and many patients experience psychological distress and various side effects from medications used to treat this condition. The objective of this study was to develop a new surgical technique for the treatment of acne.

Methods: This surgical technique utilizes tweezers to widen the hair follicle to discharge comedo and pus completely and quickly from the acne. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577948DOI Listing
February 2019

Ocular findings in patients with psoriasis: Is it related to the side effects of treatment or to psoriasis itself? A case-control study.

J Dermatolog Treat 2019 Feb 1:1-22. Epub 2019 Feb 1.

e Dermatology Department , University of Pennsylvania , Philadelphia , PA , USA.

Objectives: To assess ocular abnormalities in psoriatic patients (new-cases vs. patients under treatment) in comparison with healthy controls.

Methods: A total of 200 psoriatic patients and 100 healthy controls were enrolled in this prospective, observational study. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577947DOI Listing
February 2019

Radiation therapy techniques in the treatment of skin cancer: an overview of the current status and outlook.

J Dermatolog Treat 2019 Jan 31:1-41. Epub 2019 Jan 31.

a Chair for intelligent catheter and image guided procedures , Otto Von Guericke University , Germany.

Nonmelanoma skin cancer (NMSC) is a major health concern due to its high incidence rate, its negative impact on the quality of life of patients as well as the associated economic burden to the healthcare system. Surgery is currently the primary treatment offered for skin cancer patients but not applicable or available in all cases. Radiation therapy (RT), with its long successful history in the management of cancer, has shown to be an effective alternative or complementary method in cutaneous oncology. Read More

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http://dx.doi.org/10.1080/09546634.2019.1573310DOI Listing
January 2019
1 Read

JAK/STAT inhibitors for the treatment of atopic dermatitis.

J Dermatolog Treat 2019 Jan 31:1-8. Epub 2019 Jan 31.

a De partment of Dermatology , Centro Hospitalar e Universitário do Porto , Porto , Portugal.

Introduction: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Lesional skin of AD contains elevated levels of Th2, Th17, Th22 and Th1-citokines. With a growing movement toward use of targeted therapies, parallel to psoriasis, JAK inhibitors are an important focus of therapeutic research for AD. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577549DOI Listing
January 2019
1 Read

Laser and Laser Compound Therapy for Melasma: A Meta-Analysis.

J Dermatolog Treat 2019 Jan 31:1-19. Epub 2019 Jan 31.

b Clinical Research Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine , Guangzhou 510006 , China.

Background: Treatment of melasma is challenging because its pathogenesis is unclear and it is prone to recurrence. We performed a meta-analysis to evaluate the efficacy and safety of laser and laser compound therapy for melasma.

Methods: We searched the Cochrane, Embase, and Medline databases for all relevant studies published from inception to July 2018. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577544DOI Listing
January 2019

Biologic TNF-alpha inhibitors in the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis: a systemic review.

J Dermatolog Treat 2019 Jan 31:1-8. Epub 2019 Jan 31.

a Department of Dermatology, First Affiliated Hospital , College of Medicine, Zhejiang University , Hangzhou , China.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) is one of severe cutaneous adverse reactions with low morbidity but high mortality. Different systemic immunomodulating treatments are proposed but still remain controversial. Tumor necrosis factor (TNF)-alpha is long thought to be a vital mediator of epithelial cell death in SJS-TEN, indicating a potential target for therapy. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1577548DOI Listing
January 2019
4 Reads

The association of mycophenolate mofetil and human herpes virus infection.

J Dermatolog Treat 2019 Jan 24:1-32. Epub 2019 Jan 24.

a Departments of Dermatology , Royal Melbourne Hospital , Victoria , Australia.

Purpose Mycophenolate mofetil (MMF) is a steroid-sparing immunosuppressant used extensively to treat both common and rare dermatological conditions. Its lymphocyte specificity makes it a favourable therapeutic option particularly for patients who cannot tolerate alternative immunosuppressants. However, the side effect profile of MMF has not been extensively evaluated. Read More

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http://dx.doi.org/10.1080/09546634.2019.1572864DOI Listing
January 2019

Institute for clinical and economic review (ICER) psoriasis update 2018: what it means for dermatologists treating moderate-to-severe plaque psoriasis.

J Dermatolog Treat 2019 Jan 22:1-3. Epub 2019 Jan 22.

d Dermatology Research and Education Foundation , Irvine , CA , USA.

Objective: This paper aims to summarize the key findings of the updated report issued in August 2018 by the Institute of Clinical and Economic Review (ICER) regarding the clinical efficacy and budget impact of various immunomodulators.

Methods: This paper specifically focuses on the inclusion of two new biologics, guselkumab and certolizumab in the context of their relative cost-effectiveness using analyses on sequential implementation of specific first- and second-line therapies.

Results: The ICER found that initiating biologic therapy with an IL-17 inhibitor or guselkumab results in the most clinical improvement, but is also associated with higher costs. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1573307DOI Listing
January 2019
1 Read

Topical ketoconazole: a systematic review of current dermatological applications and future developments.

J Dermatolog Treat 2019 Jan 22:1-12. Epub 2019 Jan 22.

a Department of Dermatology , University of California , Irvine , CA, USA.

Introduction: Although labeling changes and market withdrawal have been implemented for oral ketoconazole (KTZ) due to serious adverse effects (AEs), topical KTZ is generally thought to be effective and safe for the treatment of superficial fungal infections. New dermatologic indications for the use of topical KTZ have arisen such as onychomycosis, blepharitis, and hair loss. This article aims to review the literature on topical KTZ's efficacy and AEs, as well as provide an overview on current insights regarding its mechanism of action and upcoming developments. Read More

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http://dx.doi.org/10.1080/09546634.2019.1573309DOI Listing
January 2019
2 Reads

Black tea dressings - a rapidly effective treatment for facial dermatitis.

J Dermatolog Treat 2019 Jan 22:1-4. Epub 2019 Jan 22.

a Department of Dermatology , University of Lübeck , Lübeck , Germany.

Background: Facial dermatitis is a common dermatologic condition. It is usually treated with either topical corticosteroids or calcineurin inhibitors. However, the use of these drugs is limited by side effects, including skin atrophy, local immunosuppression and possible oncogenicity. Read More

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http://dx.doi.org/10.1080/09546634.2019.1573306DOI Listing
January 2019

Tinea versicolor of the neck as side effect of topical steroids for alopecia areata.

J Dermatolog Treat 2019 Jan 22:1-3. Epub 2019 Jan 22.

a Department of Experimental, Diagnostic and Specialty Medicine, Division of Dermatology , University of Bologna , Bologna , Italy.

Background: Treatment of alopecia areata (AA) involves use of high potency topical corticosteroids under occlusion that, even very effective, can lead to several adverse effects.

Objective: We report 10 cases of patients with AA that, after using high potency topical corticosteroids, have developed tinea versicolor of the neck area.

Methods: Ten patients with AA, aged 18-38 years, were prescribed with clobetasone propionate 0. Read More

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http://dx.doi.org/10.1080/09546634.2019.1573308DOI Listing
January 2019
2 Reads

Randomized placebo-controlled clinical trial on efficacy and safety of topical 10% Potassium hydroxide for molluscum contagiosum treatment in children.

J Dermatolog Treat 2019 Jan 22:1-7. Epub 2019 Jan 22.

a Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAPJGol) , Barcelona , Spain.

Introduction: Our objective was to assess efficacy, safety and tolerance of topical potassium hydroxide (KOH) 10% for treating Molluscum contagiosum (MC) in children.

Material And Methods: Randomized, double-blind, placebo-controlled clinical trial including all children 2-16 years with MC infection attending pediatrician primary healthcare visits. The treatment was KOH 10% gel applied once daily up to clearing (maximum 30 days). Read More

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http://dx.doi.org/10.1080/09546634.2019.1573305DOI Listing
January 2019

Assessment of adherence to eczema treatment in Hong Kong children.

J Dermatolog Treat 2019 Jan 21:1-6. Epub 2019 Jan 21.

b Department of Paediatrics, Faculty of Medicine , The Chinese University of Hong Kong , Shatin , NT , Hong Kong.

Introduction: Eczema is the most common childhood skin problem in Hong Kong. Treatment adherence is crucial in symptom management and the effectiveness of eczema management. The Problematic Experiences of Therapy Scale (PETS) is used to assess adherence to treatment among children with eczema. Read More

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http://dx.doi.org/10.1080/09546634.2019.1573304DOI Listing
January 2019
1 Read

Forrest III duodenal ulcers during treatment with adalimumab for psoriasis.

J Dermatolog Treat 2019 Jan 20:1-3. Epub 2019 Jan 20.

c Institute of Gastroenterology and Hepatology , "Grigore T. Popa" University of Medicine and Pharmacy, "Sf. Spiridon" Clinical Hospital , Iaşi , Romania.

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http://dx.doi.org/10.1080/09546634.2019.1572859DOI Listing
January 2019
1 Read

Clinical and erythema-directed imaging evaluation of papulo-pustular rosacea with topical ivermectin: a 32 weeks duration study.

J Dermatolog Treat 2019 Jan 20:1-5. Epub 2019 Jan 20.

a Dermatology Clinic , University of Catania , Catania , Italy.

Background: Ivermectin (IVM) 1% cream represents an emerging therapy for papulo-pustular rosacea (PPR) and erythema-directed photography is a useful tool for evaluation of patient's erythema.

Objective: The aim of our study was to assess the efficacy of IVM in PPR in achieving clear status at 8 weeks or at 20 weeks followed by respectively 24 and 12 weeks follow-up, using clinical/instrumental evaluation.

Methods: Twenty patients with PPR were instructed to apply IVM for 8 weeks. Read More

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http://dx.doi.org/10.1080/09546634.2019.1572860DOI Listing
January 2019
1 Read

Psoriasis-Associated Itch: Etiology, Assessment, Impact, and Management.

J Dermatolog Treat 2019 Jan 21:1-29. Epub 2019 Jan 21.

d Dermatology Research and Education Foundation , Irvine , CA.

Pruritus, a very broad, subjective, and complex symptom, troubles the majority of patients with psoriasis. However, the subjective and multidimensional nature of the symptom renders it challenging for patients to appropriately communicate their experiences with itch to providers. This review explores current perspectives regarding the underlying mechanisms, assessment tools, burden, and treatment modalities for psoriatic pruritus. Read More

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http://dx.doi.org/10.1080/09546634.2019.1572865DOI Listing
January 2019
2 Reads

Efficacy of autologous whole blood or serum therapy for chronic spontaneous urticaria: A systematic review and meta-analysis.

J Dermatolog Treat 2019 Jan 21:1-28. Epub 2019 Jan 21.

a Department of Dermatology , Taipei Medical University Hospital , Taipei , Taiwan.

Background: Chronic spontaneous urticaria (CSU) is chronic wheals without identifiable exogenous stimuli. Autologous whole blood (AWB) injection and autologous serum therapy (AST) are alternative therapies for CSU that induce tolerance to circulating histamine-releasing factors.

Objective: We elucidated currently available evidence for the efficacy and safety of AWB therapy and AST for CSU. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1572863DOI Listing
January 2019
8 Reads

Consumer Preferences of Antifungal Products for Treatment and Prevention of Tinea Pedis.

J Dermatolog Treat 2019 Jan 21:1-17. Epub 2019 Jan 21.

b Weill Cornell Medicine , Department of Dermatology , NY , NY.

Tinea pedis is a common condition seen in clinical practice and has a significant impact on quality of life. Recommendations of over-the-counter antifungal products based on consumer preferences may guide dermatologists in treating patients with tinea pedis and preventing onychomycosis recurrences. Our study aimed to determine consumer preferences of antifungal products for tinea pedis, focusing on features that may guide purchases and usage. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1572862DOI Listing
January 2019
6 Reads

The 308-nm excimer laser stimulates melanogenesis via the wnt/β-Catenin signaling pathway in B16 cells.

J Dermatolog Treat 2019 Jan 21:1-5. Epub 2019 Jan 21.

a Department of Dermatology , People's Hospital of Guangxi Zhuang Autonomous Region , Nanning , PR China.

Background: The mechanism of the 308-nm excimer laser in vitiligo treatment has not yet been adequately studied. In this study, we explored the role of the 308-nm excimer laser in treatment of vitiligo and the molecular mechanisms underlying melanin biosynthesis in melanocytes after 308-nm excimer laser radiation.

Materials And Methods: The B16 cells were irradiated at doses of 0 mJ/cm, 100 mJ/cm, 300 mJ/cm and 600 mJ/cm using a 308-nm excimer laser and then cultured for an additional 24, 48 or 72 hours. Read More

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http://dx.doi.org/10.1080/09546634.2019.1572861DOI Listing
January 2019

An Update on Topical Photodynamic Therapy for Clinical Dermatologists.

J Dermatolog Treat 2019 Jan 16:1-37. Epub 2019 Jan 16.

b Veterans Affairs Medical Center , Brooklyn , NY , USA.

Introduction: Photodynamic therapy (PDT) involves the application of a topical photosensitizer, irradiation with light, and oxygen to produce cytotoxic reactive oxygen species that selectively destroy damaged cells while leaving normal skin intact. Topical PDT is a commonly used treatment for non-melanoma skin cancers (NMSCs) due to its excellent clearance rate and cosmetic outcomes. However, PDT is emerging as an off-label treatment modality for many dermatological conditions. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1569752DOI Listing
January 2019
6 Reads

A Retrospective Analysis of the use of Tap Water Iontophoresis for Focal Hyperhidrosis at a District General Hospital: The Patients' Perspective.

J Dermatolog Treat 2019 Jan 16:1-9. Epub 2019 Jan 16.

a Dermatology Department , Croydon University Hospital , Surrey , UK.

Tap water iontophoresis as a treatment for focal hyperhidrosis, is given as an initial series of treatments in hospital followed by home maintenance treatments. Our study assessed quality of life and perception of hyperhidrosis with the use of iontophoresis. All patients treated with iontophoresis at our hospital from 2012 - 2017 were retrospectively assessed (n = 82, mean age 34 years; 60% female). Read More

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http://dx.doi.org/10.1080/09546634.2019.1569751DOI Listing
January 2019
3 Reads

Comparison of prognosis in centrofacial, panfacial and hairline vitiligo: a prospective cohort study.

J Dermatolog Treat 2019 Jan 14:1-5. Epub 2019 Jan 14.

a Department of Dermatology , Huashan Hospital, Fudan University , 12 Wulumuqi Zhong Road , Shanghai 200040 , PR China.

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http://dx.doi.org/10.1080/09546634.2019.1567907DOI Listing
January 2019
1 Read

Stevens Johnson Syndrome and Toxic Epidermal Necrolysis - an Australian analysis of treatment outcomes and mortality.

J Dermatolog Treat 2019 Jan 11:1-19. Epub 2019 Jan 11.

b Department of Dermatology , Royal Adelaide Hospital , Australia.

Background: Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases with devastating consequences on morbidity and mortality. There are currently no standardized guidelines for treatment of SJS/TEN in Australia.

Method: Retrospective chart review of all SJS/TEN cases treated at the Royal Adelaide Hospital from 2000 to 2017. Read More

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http://dx.doi.org/10.1080/09546634.2019.1568380DOI Listing
January 2019
4 Reads

A case of infective endocarditis associated with atopic dermatitis perioperatively treated with dupilumab.

J Dermatolog Treat 2019 Jan 10:1-15. Epub 2019 Jan 10.

a Department of Anesthesia , Osakafu Saiseikai Noe Hospital , Osaka City , Osaka , Japan.

Background: Several case reports and reviews support a relationship between atopic dermatitis (AD) and infective endocarditis (IE). Here, we present a case of severe AD suspected of causing IE.

Case Presentation: A 21-year-old man with severe AD was admitted to our hospital due to unidentified fever, syncope, and headache. Read More

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http://dx.doi.org/10.1080/09546634.2019.1568379DOI Listing
January 2019
2 Reads

A review of the FDA's 510(k) approvals process for electromagnetic devices used in body contouring.

J Dermatolog Treat 2019 Jan 7:1-9. Epub 2019 Jan 7.

c Department of Dermatology , University Hospitals Cleveland Medical Center , USA.

Introduction: Greater demand for noninvasive techniques to reduce cellulite and contour the body have led to the growth of electromagnetic and radiofrequency devices. In this study, we aimed to characterize the evolution and safety of electromagnetic devices marketed in the U.S. Read More

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http://dx.doi.org/10.1080/09546634.2019.1566589DOI Listing
January 2019
13 Reads

Ultrasound as a Diagnostic and Interventional Aid at Point-of-Care in Dermatology Clinic: A Case Report.

J Dermatolog Treat 2018 Dec 28:1-9. Epub 2018 Dec 28.

a Department of Dermatology , University of California , Davis , CA.

Ultrasound is currently underutilized in dermatology practice. However, ultrasound provides clinicians with precise and unique information on cutaneous and subcutaneous lesions, while minimizing costs and complications related to more common and invasive diagnostic methods. We report a patient who presented with a tender subcutaneous mass that was diagnosed and treated using point-of-care ultrasound-guidance at the dermatology clinic. Read More

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http://dx.doi.org/10.1080/09546634.2018.1564231DOI Listing
December 2018

Evaluation of Using Fractional CO Laser plus NB-UVB versus NB-UVB Alone in Inducing Marginal Repigmentation of Vitiligo Lesions.

J Dermatolog Treat 2018 Dec 28:1-13. Epub 2018 Dec 28.

a Skin Research Center, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Background: Vitiligo is a common depigmenting skin disorder, characterized by patchy loss of skin color and finding effective treatment has remained a challenging issue.

Methods: A paired (half-body) randomized clinical trial study was done to compare the efficacy and the safety of narrowband ultraviolet B (NB-UVB) plus fractional CO versus NB-UVB alone in stimulation of marginal repigmentation of vitiliginous patches. One side of the body was randomly treated with a fractional CO laser and NB-UVB twice weekly, while the other side was exposed only to NB-UVB with the same manner. Read More

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http://dx.doi.org/10.1080/09546634.2018.1564232DOI Listing
December 2018

Vasoconstrictor potency of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam versus other topical corticosteroids used to treat psoriasis vulgaris.

J Dermatolog Treat 2019 Feb 3:1-5. Epub 2019 Feb 3.

a Centre de Pharmacologie Clinique Appliquée à la Dermatologie , Nice , France.

Background: It is important to determine the vasoconstrictor potencies of topical corticosteroids used to treat psoriasis to ensure appropriate clinical use.

Objective: To compare the vasoconstrictive potencies of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) (Cal/BD) cutaneous foam with other topical corticosteroids. Read More

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http://dx.doi.org/10.1080/09546634.2018.1529385DOI Listing
February 2019
2 Reads

Improving Health Literacy and Treatment Understanding of Hidradenitis Suppurativa using Group Educational Interventions.

J Dermatolog Treat 2018 Dec 22:1-16. Epub 2018 Dec 22.

a Department of Dermatology , Tufts Medical Center , Boston MA.

Background: Hidradenitis suppurativa (HS) is a chronic immune mediated skin disorder characterized by inflamed, painful abscesses most commonly located in the intertriginous regions that may lead to significant scarring and social stigma. It is unclear how much patients with HS understand about their disease.

Objective: We sought to evaluate baseline knowledge of patients who have HS, as well as to evaluate if an educational intervention of a teaching session about the disease will help increase patient's knowledge of their ailment and treatment options. Read More

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http://dx.doi.org/10.1080/09546634.2018.1562536DOI Listing
December 2018
14 Reads

The journey for US psoriasis patients prescribed a topical: a retrospective database evaluation of patient progression to oral and/or biologic treatment.

J Dermatolog Treat 2018 Dec 17:1-8. Epub 2018 Dec 17.

d Department of Dermatology , Wake Forest University School of Medicine , Winston-Salem , NC , USA.

Background: A specific sequence for psoriasis (PsO) therapy has not been defined.

Objectives: This retrospective, observational cohort study characterized pathways of PsO treatment over 3 years for newly diagnosed patients initially treated with a topical medication.

Methods: Adult PsO patients from the Explorys database (March 1 2011 to June 30 2015) were grouped according to medication-use patterns: 1) discontinued therapy; 2) topical therapy only; 3) switched/added an oral agent; and 4) switched/added a biologic agent. Read More

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http://dx.doi.org/10.1080/09546634.2018.1529386DOI Listing
December 2018
4 Reads

Omalizumab treatment in patients with severe chronic spontaneous urticaria: consideration from real-life experience in Italy.

Authors:
Riccardo Asero

J Dermatolog Treat 2018 ;29(sup3):1-2

a Ambulatorio di Allergologia, Clinica San Carlo , Paderno Dugnano , Milan , Italy.

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http://dx.doi.org/10.1080/09546634.2018.1557886DOI Listing
January 2018
1 Read

Secukinumab in the therapy of psoriasis and psoriatic arthritis: a safe choice in clinical practice.

J Dermatolog Treat 2018 Dec 8:1-4. Epub 2018 Dec 8.

a Dermatology Unit, Department of Clinical and Translational Medicine , University of Pisa , Pisa , Italy.

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https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
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http://dx.doi.org/10.1080/09546634.2018.1557875DOI Listing
December 2018
7 Reads

Oral small molecules for the treatment of atopic dermatitis: a systematic review.

J Dermatolog Treat 2018 Dec 2:1-8. Epub 2018 Dec 2.

a Department of Dermatology , University of California, Irvine , Irvine , CA , USA.

Introduction: Atopic dermatitis (AD) is a chronic, inflammatory skin disease. Conventional treatments include topical emollients, corticosteroids, calcineurin inhibitors, phototherapy, and systemic immunomodulatory agents, however, these medications have limitations in the treatment of moderate to severe AD. Current literature demonstrates that oral small molecules may be an effective modality to treat AD. Read More

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http://dx.doi.org/10.1080/09546634.2018.1544412DOI Listing
December 2018
1 Read

Recurrent oedema of the uvula in a patient with chronic spontaneous urticaria successfully treated with omalizumab.

Authors:
A Pannofino

J Dermatolog Treat 2018 Dec 4:1-4. Epub 2018 Dec 4.

a Allergology and Immunology Clinic , Operative Unit of Medicine , Policoro Hospital, Matera , Italy .

Uvula oedema is a condition characterized by a sensation of a foreign body in the oropharynx and difficulty to speak; sometimes, if associated to glottis oedema, difficulty to breathe and dysphonia are also present. Urticaria is a disease characterized by itching wheals on the skin, and sometimes angioedema. Chronic urticaria is spontaneous when the aetiology is unknown. Read More

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http://dx.doi.org/10.1080/09546634.2018.1550247DOI Listing
December 2018
4 Reads

Rapid, persistent, and simultaneous remission of urticaria and severe atopic dermatitis after treatment with omalizumab.

J Dermatolog Treat 2018 Dec 4:1-4. Epub 2018 Dec 4.

a Department of Dermatology , University of Rome "Tor Vergata".

This article reports the rapid and complete remission of concomitant chronic spontaneous urticaria and atopic dermatitis, obtained in a woman of 32 years, after treatment with omalizumab, without adverse events. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
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http://dx.doi.org/10.1080/09546634.2018.1550246DOI Listing
December 2018
10 Reads

Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of alopecia areata.

J Dermatolog Treat 2018 Dec 4:1-6. Epub 2018 Dec 4.

a International Hair Research Foundation , Milan , Italy.

Background: Alopecia areata (AA) is a non-scarring auto-immune hair disorder. Recent researches explained the role of growth factors (GFs) in hair follicle cycling. The main reservoir of GFs are alpha-granules of platelets and novel procedures have been implemented aimed at collecting platelet-rich plasma (PRP). Read More

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http://dx.doi.org/10.1080/09546634.2018.1544405DOI Listing
December 2018

Patient reported outcomes for intensified versus conventional NB-UVB treatment in non-segmental vitiligo.

J Dermatolog Treat 2018 Nov 29:1-4. Epub 2018 Nov 29.

a Netherlands Institute for Pigment Disorders, Department of Dermatology , Amsterdam University Medical Centers, University of Amsterdam , Amsterdam , the Netherlands.

Introduction: Treatment of non-segmental vitiligo (NSV) remains a challenge. Efficacy of NB-UVB treatment may increase with more frequent use or in combination with topical agents. Currently, data on the most effective treatment regimen lacking. Read More

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http://dx.doi.org/10.1080/09546634.2018.1543851DOI Listing
November 2018

Serum YKL-40 in patients with psoriasis vulgaris treated by narrow-band UVB phototherapy.

J Dermatolog Treat 2018 Nov 28:1-4. Epub 2018 Nov 28.

b Department of Dermatology, Venereology and Andrology , Aswan University , Aswan , Egypt.

Background: Psoriasis is a common chronic and immune-mediated inflammatory skin disease.

Objectives: This study aimed to investigate the serum levels of Chitinase-3-like protein 1 (YKL-40) in patients with psoriasis vulgaris before and after narrow-band ultraviolet B (NB-UVB) phototherapy.

Methods: This study was designed as a cross-sectional case-control. Read More

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http://dx.doi.org/10.1080/09546634.2018.1543848DOI Listing
November 2018
9 Reads
1.764 Impact Factor

Treatment goals in psoriasis from a patient perspective: a qualitative study.

J Dermatolog Treat 2018 Nov 27:1-15. Epub 2018 Nov 27.

a Department of Dermatology , Radboud University Medical Center , Nijmegen , the Netherlands.

Background: Psoriasis is a chronic inflammatory skin disorder with marked impact on quality of life. In view of the well-recognized need to integrate the patient perspective in psoriasis care, treatment goals which originate entirely from the experiences of the patients are of utmost importance.

Objective: To explore treatment goals in patients with psoriasis that originate entirely from the patient perspective. Read More

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http://dx.doi.org/10.1080/09546634.2018.1544408DOI Listing
November 2018
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Treatment outcome and persistence of repigmentation from narrow-band ultraviolet B phototherapy in vitiligo.

J Dermatolog Treat 2018 Nov 25:1-20. Epub 2018 Nov 25.

a Department of Dermatology , Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok , Thailand.

Background: Narrow-band ultraviolet B (NB-UVB) phototherapy is a mainstay treatment in vitiligo. However, data relative to repigmentation outcome, prognostic factors, and duration of repigmentation are limited.

Objectives: To investigate the quantitative repigmentation outcome of NB-UVB phototherapy in vitiligo, the factors associated with favorable prognosis after NB-UVB, and the duration of repigmentation after NB-UVB discontinuation. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
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http://dx.doi.org/10.1080/09546634.2018.1544409DOI Listing
November 2018
12 Reads
1.764 Impact Factor

Patient preferences for attributes of topical anti-psoriatic medicines.

J Dermatolog Treat 2018 Nov 23:1-19. Epub 2018 Nov 23.

b UCIBIO- REQUIMTE, Laboratory of Pharmaceutical Technology, Department of Drug Sciences , Faculty of Pharmacy University of Porto , Rua Jorge Viterbo Ferreira, 228 , 4050-313 Porto , Portugal.

Background Patient preferences should be considered when prescribing topical treatments to drive up adherence and improve clinical outcomes. Objetive The aim of this work was to identify the most important attributes of topical medicines for psoriasis treatment in the patients' view, and explore the sociodemographic and clinical determinants of these preferences. Methods A questionnaire for the evaluation of the relevancy given to specific attributes of topical medicines used for psoriasis treatment was developed (PSO-TOPAP) and was applied to a total of seventy-nine patients, members of the Portuguese Association of Psoriasis (PSOPortugal) or outpatients of a dermatology unit of a central hospital. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
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http://dx.doi.org/10.1080/09546634.2018.1544410DOI Listing
November 2018
14 Reads

Chronic spontaneous urticaria treated with omalizumab: report of two cases.

J Dermatolog Treat 2018 Nov 21:1-9. Epub 2018 Nov 21.

a Department of Dermatology , Papardo Hospital , Messina , Italy.

Chronic spontaneous urticaria (CSU) is a relatively common skin disease whose etiopathogenesis, as well as other factors influencing disease manifestations, are not fully understood. Mast cell function is recognised as having a central role in CSU signs and symptoms. Therapeutic options are limited; a number of drugs, recommended by international guidelines for the management of urticaria, lack regulatory approval for CSU and are prescribed off label. Read More

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http://dx.doi.org/10.1080/09546634.2018.1551608DOI Listing
November 2018
12 Reads

Omalizumab treatment in a 12 year-old girl with chronic spontaneous urticaria.

J Dermatolog Treat 2018 11 21:1-6. Epub 2018 Nov 21.

a Department of Clinical and Experimental Medicine , University of Catania , Catania , Italy.

Omalizumab is a recombinant humanized IgG monoclonal antibody, which binds the Fc region of free IgE prevent its binding to its high-affinity receptor (FcεR1) on mast cells and basophils. Omalizumab was approved as add-on therapy for moderate-to-severe persistent allergic asthma and for patients with chronic spontaneous urticaria resistant to antihistamine treatment. This article reports effective and safe treatment of a 12 years old girl with add-on omalizumab. Read More

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http://dx.doi.org/10.1080/09546634.2018.1551609DOI Listing
November 2018
5 Reads

YouTube Videos on Oral Systemic Therapies for Psoriasis: A Cross-Sectional Analysis.

J Dermatolog Treat 2018 Nov 20:1-4. Epub 2018 Nov 20.

d Dermatology Research and Education Foundation , Irvine , CA.

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http://dx.doi.org/10.1080/09546634.2018.1543850DOI Listing
November 2018

Treatment of Cutaneous Lichen Planus (Part 2): A Review of Systemic Therapies.

J Dermatolog Treat 2018 Nov 17:1-40. Epub 2018 Nov 17.

b Department of Dermatology , University of KwaZulu-Natal & Nelson Mandela School of Medicine , Durban , South Africa.

Background: Although numerous medications are available for the treatment of cutaneous lichen planus (CLP), recurrence is common and there is a lack of evidence of efficacy of many treatment options. Part 1 reviewed consolidated evidence from topical therapies and phototherapy. In Part 2, all systemic treatments are assessed. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2018.1
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http://dx.doi.org/10.1080/09546634.2018.1544411DOI Listing
November 2018
7 Reads

JAK-inhibitors in dermatology. Current evidence and future applications.

J Dermatolog Treat 2018 Nov 15:1-22. Epub 2018 Nov 15.

a Department of Dermatology , Medical University of Warsaw , Poland , 00-008 Warsaw, Koszykowa 82a.

The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti-inflammatory properties and have been approved in many countries for the treatment of rheumatoid arthritis (tofacitinib, baricitinib) and myelofibrosis or polycythemia vera (ruxolitinib). The aim of the publication was to summarize and critically analyze the efficacy and safety of JAK-inhibitors in skin diseases, such as psoriasis, alopecia areata, atopic dermatitis and vitiligo. Read More

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http://dx.doi.org/10.1080/09546634.2018.1546043DOI Listing
November 2018
3 Reads