3,221 results match your criteria Journal of Dermatological Science [Journal]


The impact of irradiance on UVB-induced cutaneous immunosuppression: Implications on administering most efficient phototherapy.

J Dermatol Sci 2019 Jan 11. Epub 2019 Jan 11.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Dermatology, Kaohsiung Medical University Hospital and Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Background: Ultraviolet B (UVB) is commonly used for treating dermatologic conditions. Recently, high irradiance UVB (HIUVB) has been suggested to be more effective for treating skin conditions as compared to its low irradiance (LI) counterpart. The biological impact of UVB radiation emitted at different irradiance on cutaneous immunity remains obscure. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2019.01.003DOI Listing
January 2019

Hypoxia accelerates the progression of angiosarcoma through the regulation of angiosarcoma cells and tumor microenvironment.

J Dermatol Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Background: Angiosarcoma is a rare malignant tumor with a poor prognosis. It is known that hypoxic condition activates tumor progression in several cancers. Additionally, hypoxic tumor microenvironment accelerates immune escape. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2019.01.005DOI Listing
January 2019

Dual wavelength 5-aminolevulinic acid photodynamic therapy using a novel flexible light-emitting diode unit.

J Dermatol Sci 2019 Jan 10. Epub 2019 Jan 10.

Department of Geriatric and Environmental Dermatology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan. Electronic address:

Background: Photosensitizers used for photodynamic therapy (PDT) to treat dermatologic disease are metabolized into mainly protoporphyrin IX (PpIX), which has five absorption wavelength peaks: 410 nm, 510 nm, 545 nm, 580 nm, and 630 nm. Although only red light around 635 nm and blue light around 400 nm are used as light sources for PDT, the efficiency of PDT might be improved by using multiple wavelengths, including those that correspond to the other absorption peaks of PpIX. Furthermore, because the target disease often occurs on the face, a flexible-type light-source unit that can be fitted to the lesion without unnecessarily exposing the mucous membranes, e. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.12.006DOI Listing
January 2019

Dyschromatosis symmetrica hereditaria and reticulate acropigmentation of Kitamura: An update.

J Dermatol Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.

Dyschromatosis symmetrica hereditaria (DSH) and reticulate acropigmentation of Kitamura (RAK) are rare, inherited pigmentary diseases. DSH shows a mixture of pigmented and depigmented macules on the extremities. RAK shows reticulated, slightly depressed pigmented macules on the extremities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811193000
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http://dx.doi.org/10.1016/j.jdermsci.2019.01.004DOI Listing
January 2019
7 Reads

Simple cell culture media expansion of primary mouse keratinocytes.

J Dermatol Sci 2018 Dec 22. Epub 2018 Dec 22.

Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD, 21287, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.12.002DOI Listing
December 2018
3.419 Impact Factor

Atypical protein kinase C isoforms differentially regulate directional keratinocyte migration during wound healing.

J Dermatol Sci 2019 Jan 8. Epub 2019 Jan 8.

Department of Dermatology & Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan. Electronic address:

Background: The epidermis possesses regenerative properties that become apparent only after wounding. Atypical protein kinase C (aPKC) isoforms aPKCζ and aPKCλ form a ternary complex with Par3 and Par6, and play crucial roles in establishing and maintaining epithelial cell polarity. The epidermal loss of aPKCλ results in progressive depletion of hair follicle stem cells. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2019.01.001DOI Listing
January 2019
1 Read

Association of glucose 6-phosphate dehydrogenase (G6PD) 3'UTR polymorphism with vitiligo and in vitro studies on G6PD inhibition in melanocytes.

J Dermatol Sci 2018 Dec 23. Epub 2018 Dec 23.

Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.12.001DOI Listing
December 2018
2 Reads
3.419 Impact Factor

Botulinum toxin blocks mast cells and prevents rosacea like inflammation.

J Dermatol Sci 2019 Jan 28;93(1):58-64. Epub 2018 Dec 28.

Department of Dermatology, University of California, San Diego, CA, USA. Electronic address:

Background: Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.

Objectives: To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183045
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http://dx.doi.org/10.1016/j.jdermsci.2018.12.004DOI Listing
January 2019
9 Reads

Nanoparticle-mediated local delivery of pioglitazone attenuates bleomycin-induced skin fibrosis.

J Dermatol Sci 2019 Jan 1;93(1):41-49. Epub 2018 Dec 1.

Department of Dermatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Background: Nanoparticle-loaded delivery systems have attracted much attention recently. Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful biodegradable polymers for biomedical applications. There are only a few studies on the treatment of dermal fibrosis with sustained-release drugs. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.012DOI Listing
January 2019
1 Read

Circulating CCL20: A potential biomarker for active vitiligo together with the number of Th1/17 cells.

J Dermatol Sci 2019 Jan 3. Epub 2019 Jan 3.

Department of Dermatology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, PR China. Electronic address:

Background: Vitiligo is an autoimmune disease with varying pathological features. Activation of the CCL20-CCR6 axis plays an important role in chronic inflammatory diseases. However, whether CCL20-CCR6 and Th1/17 cells are indicative of active vitiligo is unclear. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.12.005DOI Listing
January 2019
6 Reads
3.419 Impact Factor

The key question of irradiance when it comes to the effects of visible light in the skin.

Authors:
Thierry Passeron

J Dermatol Sci 2019 Jan 1;93(1):69-70. Epub 2018 Dec 1.

Université Côte d'Azur, Department of Dermatology, Centre Hospitalier Universitaire Nice, Nice, France; Université Côte d'Azur, INSERM U1065, team 12, C3M, Nice, France. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.011DOI Listing
January 2019

Impairment of lipophagy by PNPLA1 mutations causes lipid droplet accumulation in primary fibroblasts of Autosomal Recessive Congenital Ichthyosis patients.

J Dermatol Sci 2019 Jan 4;93(1):50-57. Epub 2018 Dec 4.

Department of Medical Biology, Hacettepe University, Ankara 06100, Turkey. Electronic address:

Background: Autosomal Recessive Congenital Ichthyosis (ARCI) is a group of epidermal keratinization disorders. One of the disease-associated proteins, patatin-like phospholipase domain-containing protein-1 (PNPLA1), plays a key role in the epidermal omega-O-acylceramide synthesis and localizes on the surface of lipid droplets (LDs).

Objective: Previously, routine clinical test results showed abnormal LD accumulation in blood smear samples of our ARCI patients with PNPLA1 mutations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183042
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http://dx.doi.org/10.1016/j.jdermsci.2018.11.013DOI Listing
January 2019
4 Reads

Dysbiosis of oral microbiota in palmoplantar pustulosis patients.

J Dermatol Sci 2019 Jan 2;93(1):67-69. Epub 2019 Jan 2.

Department of Dermatology, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Chiba, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183044
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http://dx.doi.org/10.1016/j.jdermsci.2018.12.003DOI Listing
January 2019
3 Reads

Genetic polymorphism predicting Methotrexate efficacy in Chinese patients with psoriasis vulgaris.

J Dermatol Sci 2019 Jan 28;93(1):8-13. Epub 2018 Jun 28.

Department of Dermatology, XiangYa Hospital, Hunan Key Laboratory of Skin Cancer and Psoriasis, Central South University, Changsha, Hunan, China. Electronic address:

Background: Methotrexate is the first systemic therapeutics of psoriasis. It is reported that 40% of the patients achieved a PASI75 after 12 weeks with a small dose of methotrexate (15mg / w) treatment. So far there is not any large-scale exome sequencing been used to predict the efficacy of methotrexate in the treatment of psoriasis vulgaris. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.06.009DOI Listing
January 2019
3.419 Impact Factor

Universal varicella vaccination reduced the incidence of herpes zoster in vaccine recipients 1 to 4 years of age.

J Dermatol Sci 2018 Dec 13;92(3):284-286. Epub 2018 Nov 13.

Department of Virology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 930-0194, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183040
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http://dx.doi.org/10.1016/j.jdermsci.2018.11.001DOI Listing
December 2018
8 Reads

Brahma deficiency in keratinocytes promotes UV carcinogenesis by accelerating the escape from cell cycle arrest and the formation of DNA photolesions.

J Dermatol Sci 2018 Dec 22;92(3):254-263. Epub 2018 Nov 22.

Dermatology, Central Clinical School, and Bosch Institute, University of Sydney, Sydney, NSW, Australia; Centenary Institute, Cancer Services, Royal Prince Alfred Hospital, Dermatology, Bosch Institute, University of Sydney, Camperdown, NSW 2050, Australia. Electronic address:

Background: Ultraviolet radiation (UVR) is the principal cause of keratinocyte skin cancers. Previous work found that levels of the chromatin remodelling protein, Brahma (Brm), are diminished during the progression from actinic keratoses to cutaneous squamous cell carcinomas in humans, and its loss in UV-irradiated mouse skin causes epidermal hyperplasia and increased tumour incidence.

Methods: The skins of mice and mouse and human keratinocytes deficient in Brm were exposed to UVR and evaluated for cell cycle progression and DNA damage response. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.006DOI Listing
December 2018

Glucocorticoid insensitivity by staphylococcal enterotoxin B in keratinocytes of allergic dermatitis is associated with impaired nuclear translocation of the Glucocorticoid Receptor α.

J Dermatol Sci 2018 Dec 26;92(3):272-280. Epub 2018 Nov 26.

Department of Dermatology and Rheumatology Immunology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, PR China. Electronic address:

Background: staphylococcal enterotoxin plays an important role in patients with glucocorticoid (GC)-resistant atopic dermatitis (AD), but the exact mechanism is not fully understood.

Objective: The aim of this study was to investigate the mechanisms underlying the ability of staphylococcal enterotoxin B (SEB) to induce steroid insensitivity through impaired nuclear translocation of GRα in keratinocytes.

Methods: The steroid-resistant AD induced by SEB was assessed by analyzing dermatitis score, dermal thickness, scratching behavior, infiltrating cells/HPF, levels of SEB-specific IgE and IgG2a antibody. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.010DOI Listing
December 2018
3 Reads

The first Japanese case of familial porphyria cutanea tarda diagnosed by a UROD mutation.

J Dermatol Sci 2019 Jan 15;93(1):65-67. Epub 2018 Nov 15.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.004DOI Listing
January 2019
7 Reads

Analysis of sulfated glycosaminoglycan composition change in intrinsically aged and photoaged human skin using an enzymatic degradation method.

J Dermatol Sci 2018 Dec 30;92(3):281-283. Epub 2018 Oct 30.

Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, South Korea; Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.10.003DOI Listing
December 2018

Nation-wide survey of advanced non-melanoma skin cancers treated at dermatology departments in Japan.

J Dermatol Sci 2018 Dec 3;92(3):230-236. Epub 2018 Nov 3.

Prognosis and Statistical Investigation Committee, Japanese Skin Cancer Society, Japan; Department of Dermatology and Plastic Surgery, Kumamoto University, Japan.

Background: There are limited treatment options for advanced non-melanoma skin cancers (NMSCs). To overcome this issue, we need to conduct clinical studies, however, there is a lack of information on how many patients with advanced NMSCs are treated annually in Japan.

Objective: To investigate the actual number of advanced NMSC patients in Japan. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.10.004DOI Listing
December 2018
3 Reads

TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.

J Dermatol Sci 2018 Dec 26;92(3):264-271. Epub 2018 Nov 26.

Department of Dermatology, University of California, Davis, CA, USA. Electronic address:

Background: Transient Receptor Potential Vanilloid 1 (TRPV1) is known to mediate itch and neurogenic inflammation, but the role of TRPV1 in psoriasiform dermal inflammation is poorly understood.

Objective: To investigate the function of TRPV1 in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.

Methods: Following daily treatment of topical IMQ cream for consecutive 5 days in C57BL/6 wide-type (WT) and TRPV1 gene knockout (KO) mice, we assessed the psoriasis severity index (PSI) scores, transepidermal water loss (TEWL), dermal inflammatory infiltrates, as well as gene expression levels for psoriasis related genes in mouse skin lesions. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.009DOI Listing
December 2018
2 Reads

Molecular mechanism of the ichthyosis pathology of Chanarin-Dorfman syndrome: Stimulation of PNPLA1-catalyzed ω-O-acylceramide production by ABHD5.

J Dermatol Sci 2018 Dec 20;92(3):245-253. Epub 2018 Nov 20.

Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. Electronic address:

Background: ABHD5 mutations cause Chanarin-Dorfman syndrome accompanied by ichthyosis. ω-O-Acylceramide (acylceramide) is essential for skin permeability barrier formation. Acylceramide production is impaired in Abhd5 knockout mice. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.005DOI Listing
December 2018

The different roles of 5-HT1A/2A receptors in fluoxetine ameliorated pigmentation of C57BL/6 mouse skin in response to stress.

J Dermatol Sci 2018 Dec 25;92(3):222-229. Epub 2018 Oct 25.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Background: 5-HT1A receptor was participated in fluoxetine induced melanogenesis in melanocytes and in normal C57BL/6 mice, but we know little about whether other 5-HT receptors are involved in regulation of fluoxetine promotes pigmentation.

Objective: To investigate the role of 5-HT receptors in regulation of fluoxetine ameliorates chronic unpredictable mild stress (CUMS) and chronic restraint stress (CRS) induce hypopigmentation in C57BL/6 mice.

Methods: CUMS and CRS were used to induce depigmentation in mice and evaluate the effect of fluoxetine. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.10.002DOI Listing
December 2018
1 Read

Regulatory and effector B cells: Friends or foes?

J Dermatol Sci 2019 Jan 23;93(1):2-7. Epub 2018 Nov 23.

Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan. Electronic address:

B cells have moved to the center stage in many autoimmune diseases including autoantibody-mediated diseases and T cell-mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. B cells play an important role for immune response beyond antibody production through mechanisms like antigen presentation and cytokine production. However, not all B cells positively regulate immune responses. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.008DOI Listing
January 2019
2 Reads

Stat3 activation in epidermal keratinocytes induces Langerhans cell activation to form an essential circuit for psoriasis via IL-23 production.

J Dermatol Sci 2018 Nov 23. Epub 2018 Nov 23.

Department of Dermatology, Kochi Medical School, Kochi University, Kochi, Japan.

Background: Psoriasis is an inflammatory disease associated with aberrant crosstalk between the epidermis and immune system. However, the role of Langerhans cells (LCs) in psoriasis remains controversial.

Objectives: To elucidate whether LCs are functionally involved in the development of psoriasis using a mouse model. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.007DOI Listing
November 2018
1 Read

Reduction in human hair graying by sterubin, an active flavonoid of Eriodictyon angustifolium.

J Dermatol Sci 2018 Dec 8;92(3):286-289. Epub 2018 Nov 8.

Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu 5011194, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.002DOI Listing
December 2018

Degenerated hair follicle cells and partial loss of sebaceous and eccrine glands in a familial case of axenfeld-rieger syndrome: An emerging role for the FOXC1/NFATC1 genetic axis.

J Dermatol Sci 2018 Dec 10;92(3):237-244. Epub 2018 Nov 10.

Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon. Electronic address:

Background: Cutaneous malformations are at times associated with some forms of congenital heart defects. Many a times subtle cutaneous phenotypes maybe overlooked as their significance on the lives of individuals is minimal. Lebanon represents an area of high consanguinity, where the rates can go beyond 70% in some districts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183040
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http://dx.doi.org/10.1016/j.jdermsci.2018.11.003DOI Listing
December 2018
10 Reads

Serum concentrations of HGF are correlated with response to anti-PD-1 antibody therapy in patients with metastatic melanoma.

J Dermatol Sci 2019 Jan 6;93(1):33-40. Epub 2018 Oct 6.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan.

Background: Anti-programmed cell death protein (PD)-1 antibody treatment is associated with a notable improvement in only 30%-40% of patients. Thus, a predictive and easily measured marker of the clinical benefit of anti-PD-1 antibody treatment is necessary; therefore, in this study, we focused on the serum concentration of hepatocyte growth factor (HGF).

Objectives: To evaluate whether the serum concentration of HGF can be used as a biomarker for the clinical response to anti-PD-1 antibody therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183037
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http://dx.doi.org/10.1016/j.jdermsci.2018.10.001DOI Listing
January 2019
14 Reads

Increased expression of aquaporin-1 in dermal fibroblasts and dermal microvascular endothelial cells possibly contributes to skin fibrosis and edema in patients with systemic sclerosis.

J Dermatol Sci 2019 Jan 21;93(1):24-32. Epub 2018 Sep 21.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan.

Background: Aquaporin-1 (AQP1), a water channel protein controlling the water contents of cells and tissues, exerts pleiotropic effects on various biological activities, including inflammation, angiogenesis, and extracellular matrix remodeling, by regulating cell behaviors and tissue water balance.

Objective: To investigate AQP1 roles in systemic sclerosis (SSc) which is characterized by autoimmune inflammation, vasculopathy, and tissue fibrosis.

Methods: AQP1 expression was evaluated by immunohistochemistry and quantitative reverse transcription PCR in skin samples from human and animal models and by immunoblotting in cultured cells. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.09.007DOI Listing
January 2019
3 Reads

Cell-to-cell transmission of HSV-1 in differentiated keratinocytes promotes multinucleated giant cell formation.

J Dermatol Sci 2019 Jan 18;93(1):14-23. Epub 2018 Sep 18.

Department of Dermatology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan.

Background: Herpes simplex virus (HSV) infection in the skin causes small grouped vesicles characterized by acantholytic cells and multinucleated giant cells (MGCs). Although viral factors have been studied as fusion proteins, little is known how the differentiation status of keratinocytes is involved in the formation of MGCs by HSV-1 infection.

Objective: As the human epidermis is composed of several layers of keratinocytes that undergo terminal differentiation, we aimed to elucidate whether the differentiation status of keratinocytes affects viral entry, propagation, cell-to-cell transmission of HSV-1, and MGC formation. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.09.006DOI Listing
January 2019
1 Read

Toll-like receptor signaling induces the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes.

J Dermatol Sci 2018 Nov 15;92(2):181-187. Epub 2018 Sep 15.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama, Japan.

Background: Lympho-epithelial Kazal-type inhibitor (LEKTI) tightly controls the activities of serine proteases such as kallikrein-related peptidase (KLK) 5 and KLK7 in the epidermis. LEKTI is known to be an essential molecule for the epidermal skin barrier, as demonstrated by SPINK5 nonsense mutation, which results in Netherton syndrome. Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns or damage-associated molecular patterns and produce inflammatory cytokines, chemokines, and antimicrobial peptides. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183032
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http://dx.doi.org/10.1016/j.jdermsci.2018.09.001DOI Listing
November 2018
2 Reads

Progranulin overproduction due to constitutively activated c-Abl/PKC-δ/Fli1 pathway contributes to the resistance of dermal fibroblasts to the anti-fibrotic effect of tumor necrosis factor-α in localized scleroderma.

J Dermatol Sci 2018 Nov 19;92(2):207-214. Epub 2018 Sep 19.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, 113-8655, Japan. Electronic address:

Background: Dermal fibroblasts derived from patients with systemic sclerosis (SSc) overproduce progranulin (PGRN), an endogenous antagonist of tumor necrosis factor (TNF) receptors, due to the deficiency of transcription factor Fli1. Fli1 expression is also decreased in dermal fibroblasts derived from patients with localized scleroderma (LSc).

Objective: To investigate the expression levels of PGRN and its contribution to the induction of pro-fibrotic phenotype in LSc dermal fibroblasts. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.09.005DOI Listing
November 2018
8 Reads

MicroRNA-340 inhibits squamous cell carcinoma cell proliferation, migration and invasion by downregulating RhoA.

J Dermatol Sci 2018 Nov 11;92(2):197-206. Epub 2018 Sep 11.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Dermatology, Chinese People's Liberation Army General Hospital, Beijing, China. Electronic address:

Background: MicroRNAs are reported to play an important role in tumor growth and metastasis, including squamous cell carcinoma (SCC). Accumulative evidence has revealed that dysregulated miR-340 expression contributed to the carcinogenesis and development of various cancers.

Objective: The aim of the current study was to investigate the role and the underlying mechanism of miR-340 in SCC cell proliferation, migration and invasion. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.09.003DOI Listing
November 2018
8 Reads

A broader filtration of UVA1 wavelengths improves skin photoprotection.

J Dermatol Sci 2018 Sep 28;91(3):337-340. Epub 2018 Jun 28.

L'Oréal Research and Innovation, Aulnay-sous-Bois, France.

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http://dx.doi.org/10.1016/j.jdermsci.2018.06.008DOI Listing
September 2018
3.420 Impact Factor

Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup.

J Dermatol Sci 2018 Nov 11;92(2):127-133. Epub 2018 Sep 11.

Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan. Electronic address:

Background: Congenital ichthyoses (CIs) adversely affect quality of life (QOL) in patients. However, the effects of CIs on patient QOL have not been studied sufficiently.

Objective: To investigate the association between disease severity and QOL in patients with harlequin ichthyosis (HI) and ichthyosis: syndromic forms (ISFs) METHODS: Clinical information of patients with HI and ISFs from 2010 to 2015 were obtained from 100 dermatology departments/divisions of principal institutes/hospitals throughout Japan. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.08.008DOI Listing
November 2018
4 Reads

Neutrophils contribute to vasculitis by increased release of neutrophil extracellular traps in Behçet's disease.

J Dermatol Sci 2018 Nov 31;92(2):143-150. Epub 2018 Aug 31.

Department of Anatomy, Cell Biology and Physiological Science, American University of Beirut, Beirut, Lebanon; Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon; Hôpital Cochin Tarnier, Département de Dermatologie, Université Paris Descartes, Paris, France. Electronic address:

Background And Objectives: Behçet's disease (BD) is a multi-system inflammatory disorder that can cause vasculitis. Here we questioned whether Neutrophils in BD cause vasculitis via releasing Neutrophil Extracellular Traps (NETs), a process called NETosis.

Methods: Circulating neutrophils were isolated from a cohort of Middle Eastern BD patients with an active disease and healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.08.010DOI Listing
November 2018
1 Read

Low-dose UVB therapy is comparable with conventional UVB phototherapy for treatment of vitiligo: A pilot study.

J Dermatol Sci 2018 Nov 31;92(2):218-220. Epub 2018 Aug 31.

Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183030
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http://dx.doi.org/10.1016/j.jdermsci.2018.08.006DOI Listing
November 2018
18 Reads

The mTOR-inhibitor Sirolimus decreases the cyclosporine-induced expression of the oncogene ATF3 in human keratinocytes.

J Dermatol Sci 2018 Nov 5;92(2):172-180. Epub 2018 Sep 5.

Skin Cancer Center Hannover, Department for Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

Background: Due to their immunosuppressive therapy, organtransplant recipients (OTRs) exhibit a high incidence for the development of cutaneous squamous cell carcinoma (cSCC). Randomized studies of kidney-transplanted patients indicate a significant lower susceptibility for cSCC among patients receiving the mTOR-inhibitor Sirolimus, compared to patients without mTOR-regimen. The exact mechanism, how mTOR inhibition affects keratinocyte carcinogenesis remains unclear. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.08.013DOI Listing
November 2018

The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata.

J Dermatol Sci 2018 Nov 7;92(2):188-196. Epub 2018 Sep 7.

Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan; Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan. Electronic address:

Background: Atopic dermatitis (AD) is an inflammatory skin disease with an associated barrier dysfunction and Staphylococcus aureus infection. The mainstay steroid and calcineurin inhibitor therapy shows some adverse effects. 2,4-Dimethoxy-6-methylbenzene-1,3-diol (DMD) is a benzenoid isolated from Antrodia camphorata. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183032
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http://dx.doi.org/10.1016/j.jdermsci.2018.09.002DOI Listing
November 2018
10 Reads
3.420 Impact Factor

Ethyl 2,4-dicarboethoxy pantothenate, a derivative of pantothenic acid, prevents cellular damage initiated by environmental pollutants through Nrf2 activation.

J Dermatol Sci 2018 Nov 9;92(2):162-171. Epub 2018 Sep 9.

School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakuracho, Hachiouji, Tokyo 192-0982, Japan. Electronic address:

Background: Recently, environmental pollutants have become a concern not only for respiratory organs but also for skin-related human health, because skin is localized at the border between the human body and the external environment and is easily influenced by environmental pollutants.

Objective: Here, we investigated the effects of a novel pantothenic acid (PA) derivative, ethyl 2,4-dicarboethoxy pantothenate (EDCEP), on a diesel particulate extract (DPE) as a representative environmental pollutant that generates reactive oxygen species (ROS) through the activation of aryl hydrocarbon receptor (AHR) signaling.

Methods: We characterized the effects of PA and EDCEP on normal human epidermal keratinocytes (NHEKs) exposed to DPE or HO as a general oxidative stress stimulator. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811173069
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http://dx.doi.org/10.1016/j.jdermsci.2018.08.012DOI Listing
November 2018
15 Reads

Topical 3-bromopyruvate is a novel targeted therapy for melanoma in a preclinical model.

J Dermatol Sci 2018 Nov 30;92(2):134-142. Epub 2018 Aug 30.

Department of Dermatology and Plastic Surgery, Japan. Electronic address:

Background: Targeting cancer metabolism is a promising strategy in improving cancer treatment.

Objective: To introduce a targeted therapy with topical 3-bromopyruvate (3BP), aglycolytic inhibitor, into the clinic in the near future.

Method: We investigated the anti-tumor efficacy of 3BP on melanoma cells in vitro and in a preclinical model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183032
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http://dx.doi.org/10.1016/j.jdermsci.2018.08.009DOI Listing
November 2018
7 Reads

BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation.

J Dermatol Sci 2018 Nov 31;92(2):151-161. Epub 2018 Aug 31.

Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background: B lymphocyte-induced maturation protein-1 (BLIMP1) is a transcriptional repressor, and plays a crucial role in the regulation of development and functions of various immune cells. Currently, there is limited understanding about the regulation of BLIMP1 expression in keratinocytes and crosstalk between EGFR and BLIMP1 in skin homeostasis.

Objective: The aim of the study was to investigate the regulation and functional link between EGFR and BLIMP1 in human epidermal keratinocytes. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.08.011DOI Listing
November 2018
1 Read

Subcutaneous infection with dematiaceous fungi in Card9 knockout mice reveals association of impair neutrophils and Th cell response.

J Dermatol Sci 2018 Nov 24;92(2):215-218. Epub 2018 Aug 24.

Department of Dermatology, Peking UniversityFirst Hospital, Research Center for Medical Mycology, Peking University, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.08.005DOI Listing
November 2018
1 Read

The vitamin D analog, maxacalcitol, reduces psoriasiform skin inflammation by inducing regulatory T cells and downregulating IL-23 and IL-17 production.

J Dermatol Sci 2018 Nov 24;92(2):117-126. Epub 2018 Aug 24.

Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.

Background: Psoriasis is a Th1/Th17-mediated inflammatory dermatosis treated with topical corticosteroids and vitamin D analogs (VD3 As).

Objective: To compare the effects of a VD3 A maxacalcitol and betamethasone valerate (BV) steroid lotion on topical imiquimod (IMQ)-induced psoriasiform skin inflammation.

Methods: Female BALB/c mice were treated with vehicle, maxacalcitol or BV lotion on the skin for 3 days, and IMQ cream for 6 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183030
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http://dx.doi.org/10.1016/j.jdermsci.2018.08.007DOI Listing
November 2018
12 Reads

An overview of epidermal lamellar bodies: Novel roles in biological adaptations and secondary barriers.

J Dermatol Sci 2018 Oct 8;92(1):10-17. Epub 2018 Mar 8.

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea.

The epidermal lamellar bodies (LBs) are specialized organelles that contain pro-barrier lipids imparting a fully lamellar internal structure, but also other cargoes such as enzymes (lipid metabolizing and proteolytic), enzyme inhibitors, and antimicrobial peptides. Thus, the LB secretory system, by virtue of delivering these cargoes to the stratum corneum (SC) interstices, is essential for forming the various skin barriers located in the SC. Ultrastructural studies have suggested that the morphologic features of LBs reflect the functional status of the SC. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.03.005DOI Listing
October 2018
1 Read

Mechanistic and pharmacological assessment of murine IL-23 mediated psoriasiform dermatitis; implications for drug discovery.

J Dermatol Sci 2018 Oct 7;92(1):45-53. Epub 2018 Aug 7.

AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States.

Background: Animal models of Psoriasis (PsO) are important for our understanding of the pathophysiology of human disease but rarely manifest all features of the disease. In order to facilitate greater understanding of the underlying biology of PsO it is key that we understand the strengths and limitations of models used.

Objective: While humanized mouse models are available for PsO they remain technically challenging, expensive, require prolonged timelines and require a continued source of human tissue. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.08.001DOI Listing
October 2018
19 Reads

Generation of trichogenic adipose-derived stem cells by expression of three factors.

J Dermatol Sci 2018 Oct 16;92(1):18-29. Epub 2018 Aug 16.

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, South Korea; STEMORE Co. Ltd., Incheon, South Korea. Electronic address:

Background: Previous studies demonstrated that adipose-derived stem cells (ASCs) can promote hair growth, but unmet needs exist for enhancing ASC hair inductivity.

Objective: Therefore, we introduced three trichogenic factors platelet-derived growth factor-A, SOX2, and β-catenin to ASCs (tfASCs) and evaluated whether tfASCs have similar characteristics as dermal papilla (DP) cells.

Method: Global gene expression was examined using NGS analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811183030
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http://dx.doi.org/10.1016/j.jdermsci.2018.08.004DOI Listing
October 2018
19 Reads

The effect of levamisole in the treatment of recalcitrant recurrent erythema multiforme major: An observational study.

J Dermatol Sci 2018 Oct 8;92(1):38-44. Epub 2018 Aug 8.

Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou and Keelung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Memorial Hospital, Xiamen, China. Electronic address:

Background: Erythema multiforme major (EMM) is an immune-mediated mucocutaneous eruption mostly triggered by herpes simplex virus (HSV) infection. A vicious circle of recurrence may be developed due to HSV reactivation and prolonged use of systemic corticosteroids to control EMM. Levamisole is an immunomodulator and has been applied to prevent relapses of recurrent HSV infection. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.08.002DOI Listing
October 2018
2 Reads
3.420 Impact Factor

Tetrathiomolybdate, a copper chelator inhibited imiquimod-induced skin inflammation in mice.

J Dermatol Sci 2018 Oct 11;92(1):30-37. Epub 2018 Aug 11.

Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan. Electronic address:

Background: Copper is an essential metal for maintenance of many biological functions; however, excessive amount can induce inflammation and oxidative stress. Tetrathiomolybdate (TM) is a copper chelator for treatment of Wilson's disease, and decreased the severity of autoimmune arthritis in mice.

Objective: In this report, we evaluated the effects of TM in a mouse model for psoriasis. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2018.08.003DOI Listing
October 2018
1 Read