4,910 results match your criteria Journal of Cutaneous Pathology[Journal]


Plaque-like myofibroblastic tumor, a rare entity of childhood: possible pitfalls in differential diagnosis.

J Cutan Pathol 2019 Feb 9. Epub 2019 Feb 9.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.

Plaque-like myofibroblastic tumor is a rare and benign pediatric soft tissue tumor. It presents as a slowly growing plaque reaching several centimeters in diameter, made up of multiple nodules. The clinical and histological features of this benign entity are similar to other fibrohistiocytic or myofibroblastic tumors occuring in childhood, so the diagnosis can be difficult. Read More

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http://dx.doi.org/10.1111/cup.13441DOI Listing
February 2019

Clinical Factors Associated with Cutaneous Histopathologic Findings in Dermatomyositis.

J Cutan Pathol 2019 Feb 9. Epub 2019 Feb 9.

Department of Dermatology, Stanford University School of Medicine, Stanford, CA.

Background: Common histopathologic findings in cutaneous dermatomyositis include vacuolar interface with dyskeratosis, mucin, and perivascular inflammation. Data examining the relationships between these and other histologic abnormalities, or their dependence on biopsy site, and medications is limited.

Methods: Using 228 dermatomyositis skin biopsies and statistical analyses including Chi-squared analyses, calculations of relative risk, and adjusted GEE regressions we investigated relationships between 14 histopathologic findings and the impact of clinical factors on these findings. Read More

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http://doi.wiley.com/10.1111/cup.13442
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http://dx.doi.org/10.1111/cup.13442DOI Listing
February 2019
5 Reads

A rare pitfall in the molecular interpretation of BRAF V600E status in melanoma in the setting of BRAF V600E-mutated chronic lymphocytic leukemia/small lymphocytic lymphoma.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Pathology Queensland, Princess Alexandra Hospital Laboratory, Woolloongabba, Queensland, Australia.

BRAF mutation status is a critical predictive and prognostic biomarker in guiding management of unresectable and metastatic melanoma. We recently observed a case of BRAF V600E-mutated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) intermixed with BRAF V600E wild-type melanoma reported to harbor BRAF V600E mutation on molecular testing. Our observation underscores the importance of appropriate tumor selection for molecular studies and knowledge of mutational status of co-existing tumors. Read More

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http://dx.doi.org/10.1111/cup.13440DOI Listing
February 2019
1 Read

Sweet syndrome with pseudocarcinomatous hyperplasia: A case report and review of the literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

University of Minnesota, Department of Dermatology, 516 Delaware Street S.E., Mail Code 98, Phillips-Wangensteen Bldg., Suite 4-240, Minneapolis, Minnesota 55455.

Pseudocarcinomatous (pseudoepitheliomatous) hyperplasia represents reactive epidermal change mimicking squamous cell carcinoma (SCC), owing to a variety of inflammatory and neoplastic phenomena, including deep fungal infections, CD30-positive lymphomas, and others. We report a case of Sweet syndrome (SS) arising in a patient with acute myelogenous leukemia, with persistent orolabial involvement which mimicked SCC both clinically and microscopically, but resolved entirely with adequate corticosteroid treatment. Clinicians should be aware that neutrophilic dermatoses such as SS and pyoderma gangrenosum may rarely exhibit pseudocarcinomatous epidermal changes similar to those seen in soft tissue infections and other inflammatory dermatoses. Read More

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http://dx.doi.org/10.1111/cup.13436DOI Listing
February 2019
1 Read

Plamacytoid dendritic cells in granulomatous variant of mycosis fungoides.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Department of Dermatology, Los Angeles, California,, USA.

Introduction: Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas are associated with other typical signs of MF. Its prognosis is worse than that of classical MF. Plasmacytoid dendritic cells (PDC) are a subset of Interferon (IFN) producing dendritic cells that link the innate and the adaptative immune responses. Read More

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http://dx.doi.org/10.1111/cup.13438DOI Listing
February 2019

LICHENOID FOLLICULITIS OF THE SCALP IN FOUR PATIENTS WITH ICHTHYOSIFORM SKIN DISORDERS AND CICATRICIAL ALOPECIA.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, Federal Fluminense University, Antonio Pedro University Hospital, Marques de Parana Avenue, Niteroi, 24220-900, Brazil.

Ichthyosis is a heterogeneous group of inherited skin disorders characterized by a defect of keratinization. Patients diagnosed with lamellar ichthyosis (LI) and some ichthyosiform syndromes, such as the Conradi-Hünermann-Happle syndrome (CHHS), usually present with hair loss. Even though only few dermatologic complaints carry as many emotional overtones as hair loss, there is extremely little data available in the literature regarding scalp histopathologic features on ichthyosis. Read More

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http://dx.doi.org/10.1111/cup.13439DOI Listing
February 2019

Bowen Disease with Invasive Mucin-Secreting Sweat Gland Differentiation: Report of a Case and Review of the Literature.

J Cutan Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Central Zone (Halifax), NS,, Canada.

Bowen Disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. Read More

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http://dx.doi.org/10.1111/cup.13437DOI Listing
February 2019
1 Read

A cellular blue nevus with pigmented epithelioid melanocytoma-like pattern on the ipsilateral upper arm associated with a congenital plaque-type blue nevus on the hand.

J Cutan Pathol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

A 36-year-old man presented with a subcutaneous nodule on the right upper arm. A small nodule had developed 8 years earlier, and grew in size, accompanied by a tingling sensation and numbness. In addition, he had a bluish irregular patch on the right hand since birth, which crossed from the palm to the dorsal hand. Read More

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http://dx.doi.org/10.1111/cup.13435DOI Listing
February 2019
1 Read

Differential Distribution of the Epigenetic Marker 5-hydroxymethylcytosine Occurs in Hair Follicle Stem Cells during Bulge Activation.

J Cutan Pathol 2019 Feb 4. Epub 2019 Feb 4.

Department of Pathology, Program in Dermatopathology, Brigham and Women's Hospital, Boston, MA.

Background: Hair follicle cycling is dependent upon activation and differentiation of an epithelial subpopulation of cells with stem-like characteristics. These cells express cytokeratin 15 (CK15) and are sequestered within a specialized niche termed the follicular bulge. The pathways that mediate bulge activation are poorly understood, although growing evidence suggests a role for epigenetic events. Read More

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http://dx.doi.org/10.1111/cup.13434DOI Listing
February 2019
1 Read

Rare Risky Recurrent: An Enigmatous Cutaneous Polyp.

J Cutan Pathol 2019 Jan 25. Epub 2019 Jan 25.

Pathology Department of Pathology ANIIMS Port Blair.

Myxofibrosarcomas (MFS) are sarcomas most commonly seen in older patients. These are tumors of deep soft tissue seen in subcutaneous tissue, deep fascia with frequent muscle involvement. These sarcomas are notorious for recurrences, progression to a higher grade with notable metastatic potential. Read More

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http://dx.doi.org/10.1111/cup.13432DOI Listing
January 2019

"IgG/IgA Pemphigus in a Patient with a History of Pemphigus Vulgaris: An Example of Epitope Spreading?

J Cutan Pathol 2019 Jan 25. Epub 2019 Jan 25.

Division of Dermatology, University of Virginia Medical Center, Charlottesville, VA.

The dual presentation of IgG and IgA positivity on direct immunofluorescence (DIF) constitutes a rare form of pemphigus. IgG/IgA pemphigus varies widely in clinical and pathologic presentation. Reported sites of involvement range from the trunk as the sole site of involvement to the whole body and oral mucosa as well as the conjunctiva and esophagus . Read More

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http://dx.doi.org/10.1111/cup.13433DOI Listing
January 2019

Cutaneous involvement as the first manifestation of T-lymphoblastic lymphoma and review of the literature.

J Cutan Pathol 2019 Jan 24. Epub 2019 Jan 24.

Department of Pathology, Hospital Universitario de La Princesa, Madrid, Spain.

Lymphoblastic lymphomas (LBL) are uncommon malignant neoplasms derived from immature T- or B- lymphoid progenitor cells. Although cutaneous involvement may reach 33% in B-LBL, only twelve cutaneous cases of T- LBL have been published. We report the case of a 49-year-old woman with 2-month history of erythematous-violaceous plaques in the sternal region and breasts. Read More

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http://dx.doi.org/10.1111/cup.13431DOI Listing
January 2019

Primary Cutaneous Hodgkin-like Polymorphic Post-Transplant Lymphoproliferative Disorder.

J Cutan Pathol 2019 Jan 22. Epub 2019 Jan 22.

Department of Dermatology, Baylor College of Medicine, Houston, TX.

Post-transplant lymphoproliferative disorder (PTLD) is an uncommon complication after solid organ transplants and hematopoietic stem cell transplants. Isolated involvement of the skin without systemic involvement in PTLD is extremely rare. Primary cutaneous PTLD is generally categorized as either cutaneous T-cell lymphomas or cutaneous B-cell lymphomas, with variable Epstein-Barr virus (EBV) positivity. Read More

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http://dx.doi.org/10.1111/cup.13427DOI Listing
January 2019
1 Read

Distinguishing pustular psoriasis and acute generalized exanthematous pustulosis (AGEP) on the basis of plasmacytoid dendritic cells (PDCs) and MxA protein.

J Cutan Pathol 2019 Jan 22. Epub 2019 Jan 22.

Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.

Background: Distinguishing acute generalized exanthematous pustulosis (AGEP) and pustular psoriasis (PS) can be challenging. Staining for plasmacytoid dendritic cells, or PDCs (producer of IFN-α/β),[1] and MxA (an IFN-α/β inducible protein)[2] may help discriminate these entities.

Methods: Forty-three cases of AGEP and PS were compiled from two academic institutions. Read More

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http://dx.doi.org/10.1111/cup.13430DOI Listing
January 2019

Facial pustules due to drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms may histopathologically mimic eosinophilic pustular folliculitis: a case report.

J Cutan Pathol 2019 Jan 22. Epub 2019 Jan 22.

Department of Dermatology, Nara Medical University School of Medicine, Nara, Japan.

Pustules with facial and/or neck edema is one characteristic feature of drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) at the early stage. Although several retrospective histopathologic studies on DIHS/DRESS have been reported, the detailed histopathologic findings of facial pustules for DIHS/DRESS are unavailable. We herein report a case of DIHS/DRESS with facial pustules that was histopathologically similar to eosinophilic pustular folliculitis (EPF). Read More

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http://dx.doi.org/10.1111/cup.13428DOI Listing
January 2019
1 Read

Expression of p15 in a spectrum of spitzoid melanocytic neoplasms.

J Cutan Pathol 2019 Jan 21. Epub 2019 Jan 21.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Background: Accurate classification of spitzoid melanocytic lesions is difficult due to overlapping clinical and histopathologic features between Spitz nevi, atypical Spitz tumors (ASTs), and spitzoid melanomas. Expression of p16 (CDKN2A) has been used as a marker of spitzoid lesions. However, its expression may be variable. Read More

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http://doi.wiley.com/10.1111/cup.13424
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http://dx.doi.org/10.1111/cup.13424DOI Listing
January 2019
4 Reads

Pyogenic granuloma over the venous component of a mixed vascular malformation.

J Cutan Pathol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pathology, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain.

A 52-year-old man presented with a rapidly growing red tumor on the central neckline. It had appeared over a congenital flat and pinkish vascular lesion that involved the shoulder and the upper anterior area of his chest. Intermingled with the pinkish stain, there were also some blue nodules several millimeters in diameter. Read More

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http://doi.wiley.com/10.1111/cup.13429
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http://dx.doi.org/10.1111/cup.13429DOI Listing
January 2019
2 Reads

A primary cutaneous vascular neoplasm with histologic features of anastomosing hemangioma.

J Cutan Pathol 2019 Jan 21. Epub 2019 Jan 21.

Departments of Pathology/Microbiology, Pediatrics and Orthopaedic Surgery, Omaha, NE.

Anastomosing hemangioma (AH) is a relatively novel variant of benign vascular tumors originally described in the genitourinary tract. Although AH was subsequently documented in various anatomic locations, a primary AH of the skin has not been reported in the literature. The current case report documents a vascular lesion with histologic features reminiscent of an anastomosing hemangioma. Read More

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http://doi.wiley.com/10.1111/cup.13426
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http://dx.doi.org/10.1111/cup.13426DOI Listing
January 2019
2 Reads

Lucio Phenomenon mimicking antiphospholipid syndrome: the occurrence of antiphospholipid antibodies in a leprosy patient.

J Cutan Pathol 2019 Jan 21. Epub 2019 Jan 21.

Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.

Lucio phenomenon is an atypical reaction of leprosy, characterized by vasculitic lesions that can mimic antiphospholipid syndrome (APS) clinically. Distinguishing the two can be difficult as antiphospholipid autoantibodies could be present in patients with leprosy. We report on a 32-year-old female patient presenting with a sudden onset of fever, hemorrhagic bullae, and skin necrosis on her lower legs. Read More

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http://dx.doi.org/10.1111/cup.13425DOI Listing
January 2019
1.560 Impact Factor

Nipple leiomyoma: A rare neoplasm with a broad spectrum of histologic appearances.

J Cutan Pathol 2019 Jan 20. Epub 2019 Jan 20.

Department of Pathology, Oregon Health & Science University, Portland, Oregon.

Cutaneous leiomyomas are rare benign smooth-muscle tumors. These lesions are distinguished based on their cell of origin and are subclassified as pilar leiomyoma, angioleiomyoma, and genital-type leiomyoma. Nipple leiomyoma is the least common genital-type leiomyoma, arising from the dartoic muscle cell of the nipple. Read More

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http://dx.doi.org/10.1111/cup.13423DOI Listing
January 2019
1 Read

Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases.

J Cutan Pathol 2019 Jan 20. Epub 2019 Jan 20.

Department of Dermatology, Yale University School of Medicine, New Haven, CT.

Background: Epidermolytic acanthoma (EA) is a rare, benign acquired cutaneous keratosis displaying epidermolytic hyperkeratosis in more than 50% of its surface. Because of the sparsity of comprehensive studies, little is known on the patient demographics and clinical characteristics of this uncommon entity. We wish to comprehensively characterize the clinical and demographic features of EA and to differentiate it from its mimickers. Read More

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http://dx.doi.org/10.1111/cup.13422DOI Listing
January 2019
1 Read

Hypocellular medallion-like dermal dendrocyte hamartoma on the abdomen of a 25 year old male.

J Cutan Pathol 2019 Jan 11. Epub 2019 Jan 11.

Department of Dermatology, Philadelphia College of Osteopathic Medicine, Roswell, Georgia.

Medallion-like dermal dendrocyte hamartoma is a rare congenital lesion that is more commonly seen in females. It often presents at birth on the neck or upper trunk as a well-circumscribed, atrophic patch with wrinkling of the overlying skin. Clinically, the differential diagnosis includes atrophoderma, anetoderma, and congenital atrophic dermatofibrosarcoma protuberans. Read More

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http://dx.doi.org/10.1111/cup.13421DOI Listing
January 2019
5 Reads

Cutaneous myxomas and a psammomatous melanotic schwannoma in a patient with Carney complex.

J Cutan Pathol 2019 Feb;46(2):93-96

Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1111/cup.13385DOI Listing
February 2019
1 Read

Precalcaneal congenital fibrolipomatous hamartoma: Rare or under-reported?

J Cutan Pathol 2019 Jan 11. Epub 2019 Jan 11.

Department of Pathology, University College of Medical Sciences & GTB Hospital (University of Delhi), Delhi, India.

Precalcaneal congenital fibrolipomatous hamartoma (PCFH) is a benign under-reported condition of infancy characterized by the presence of soft nodules on precalcaneal plantar surface of the heel. These lesions are usually bilateral solitary and asymptomatic. We present a 2-month-old infant with solitary skin-colored nodules present on precalcaneal plantar aspect of bilateral heels. Read More

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http://dx.doi.org/10.1111/cup.13414DOI Listing
January 2019
1.560 Impact Factor

Low-grade fibromyxoid sarcoma of acral sites: Case report and literature review.

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue sarcoma that usually presents as a deep-seated tumor in young adults; however, they can occur on superficial sites, mostly documented in pediatric age groups. LGFMS presenting on acral sites is not highly emphasized in the general pathology or dermatopathology literature. The case presented is that of a 30-year-old man with a foot mass that was removed 15 years earlier and subsequently recurred as two masses, the first occurring between the third and fourth toes/metatarsal region and the second over the lateral tarsal region. Read More

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http://doi.wiley.com/10.1111/cup.13413
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http://dx.doi.org/10.1111/cup.13413DOI Listing
January 2019
2 Reads

Cutaneous leukocytoclastic vasculitis as the first manifestation of malignant syphilis coinfected with human immunodeficiency virus.

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Department of Dermatology and Venerology, First Hospital of Jilin University, Changchun, Jilin, China.

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http://dx.doi.org/10.1111/cup.13420DOI Listing
January 2019
2 Reads

Differential expression of phospho-S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation.

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

Background: The role of the mammalian target of rapamycin (mTOR) in hair follicle tumorigenesis is unclear. mTOR controls cell growth and can be activated through ribosomal S6 kinase. Herein, we sought to evaluate the expression of phospho-S6 in six different benign and malignant follicular tumor types. Read More

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http://doi.wiley.com/10.1111/cup.13411
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http://dx.doi.org/10.1111/cup.13411DOI Listing
January 2019
2 Reads

Diagnostic utility of dual 5-hydroxymethylcytosine/Melan-A immunohistochemistry in differentiating nodal nevus from metastatic melanoma: An effective first-line test for the workup of sentinel lymph node specimen.

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

Background: Distinguishing benign nodal nevus from metastatic melanoma can be diagnostically challenging, with important clinical consequences. Recently, the loss of epigenetic marker, 5-hydroxymethylcytosine (5-hmC) expression by immunohistochemistry has been found in melanomas and atypical melanocytic neoplasms.

Methods: About 41 metastatic melanomas and 20 nodal nevi were retrieved. Read More

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http://dx.doi.org/10.1111/cup.13412DOI Listing
January 2019

Clinical and histopathologic study of 39 patients with imported tungiasis.

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Tungiasis is an infestation caused by the penetration into the skin of the flea Tunga penetrans. Histopathologic studies on imported tungiasis are rare and based on a limited number of cases.

Methods: We carried out a review of 39 biopsy specimens collected from 39 patients with imported tungiasis. Read More

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http://dx.doi.org/10.1111/cup.13410DOI Listing
January 2019

Multiple facial plaque variant of trichoblastoma.

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Departments of Dermatology and Pathology, Instituto Valenciano de Oncología, Valencia, Spain.

Background: The plaque variant of trichoblastoma has been described as a solitary tumor with diffuse infiltration of the lower dermis and hypodermis, with poorly defined borders. Herein, we report a new variant of multiple centrofacial trichoblastoma.

Object: To describe clinical and pathological features of a new multiple kind of plaque variant of centrofacial trichoblastoma. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13416
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http://dx.doi.org/10.1111/cup.13416DOI Listing
January 2019
2 Reads

Cutaneous ganglioneuroma: A case report and discussion of the literature.

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Department of Dermatology, Largo Medical Center, Largo, Florida.

Ganglioneuromas (GNs) are benign tumors composed of ganglion cells in a Schwannian stroma. They are derived from neural crest cells that give rise to the sympathetic nervous system. Hence, GNs can be found anywhere a sympathetic ganglion is present. Read More

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http://dx.doi.org/10.1111/cup.13419DOI Listing
January 2019

Tufted-angioma-like lesion associated with vascular endothelial growth factor and interleukin-6 in TAFRO syndrome: Is it a common histological feature of multicentric Castleman disease/POEMS syndrome?

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Department of General Medicine, Tenri Hospital, Nara, Japan.

The histology of skin lesions of TAFRO (thrombocytopenia, anasarca, reticulin fibrosis/renal failure, and organomegaly) syndrome has rarely been reported. We report herein two cases of TAFRO syndrome with characteristic vascular skin lesions. The lesions resembled a tufted angioma, although those of case 1 partially resembled a glomeruloid hemangioma, which was known as a specific lesion in POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes), a variant of multicentric Castleman disease (MCD). Read More

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http://dx.doi.org/10.1111/cup.13415DOI Listing
January 2019
1 Read

Histiocytoid Sweet Syndrome (HSS) Harboring an IDH-1 Mutation: A Case Report and Retrospective Analysis of 29 Cases of HSS.

J Cutan Pathol 2019 Jan 10. Epub 2019 Jan 10.

Albert Einstein College of Medicine, Division of Dermatology, Bronx, NY.

Histiocytoid Sweet syndrome (HSS) is a rare histopathologic variant of Sweet syndrome that was first described in 2005 by Requena et al. In contrast to the dense infiltrate of mature neutrophils seen in conventional Sweet syndrome, this variant demonstrates dermal and/or subcutaneous infiltrate with a prominent component of immature myeloid cells resembling histiocytes. (1) A number of publications have since reported similar findings, sometimes in association with hematologic neoplasms. Read More

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http://doi.wiley.com/10.1111/cup.13418
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http://dx.doi.org/10.1111/cup.13418DOI Listing
January 2019
6 Reads

Histological findings and pathologic diagnosis of spiradenocarcinoma: A case series and review of the literature.

J Cutan Pathol 2018 Dec 27. Epub 2018 Dec 27.

Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Atypical spiradenoma and spiradenocarcinoma present a diagnostic challenge. We aim to assess the significance of certain histologic features, which may facilitate diagnosis of these tumors.

Methods: A natural language search for cases of "atypical spiradenoma" and "spiradenocarcinoma" diagnosed between 2009 and 2018 was performed. Read More

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http://doi.wiley.com/10.1111/cup.13408
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http://dx.doi.org/10.1111/cup.13408DOI Listing
December 2018
2 Reads

Pilomatrical carcinosarcoma of the temple: A case report.

Authors:
Daisuke Mori

J Cutan Pathol 2018 Dec 24. Epub 2018 Dec 24.

Department of Pathology, Saga-ken Medical Centre Koseikan, Saga, Japan.

Pilomatrical carcinosarcoma is a very rare entity, with only six cases reported until now. This report describes the case of a 100-year-old woman with a mass on the left temple that had existed for several decades but had recently grown in size. Histology showed an asymmetric lesion composed of basaloid cells, spindle cells, and "shadow" or "ghost" cells. Read More

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http://doi.wiley.com/10.1111/cup.13407
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http://dx.doi.org/10.1111/cup.13407DOI Listing
December 2018
6 Reads

Neuroblastoma-like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor.

J Cutan Pathol 2019 Mar 15;46(3):234-237. Epub 2019 Jan 15.

Dermatopathology Lake Constance, Friedrichshafen, Germany.

Neuroblastoma-like schwannoma (NLS) is a rare variant of a common tumor. The aim of this study is to discuss, through a literature review, the differential diagnoses of NLS while emphasizing the importance of ancillary studies. So far, 24 cases have been reported. Read More

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http://dx.doi.org/10.1111/cup.13405DOI Listing

A case of primary cutaneous Ewing sarcoma in a neutropenic patient.

J Cutan Pathol 2019 Mar 16;46(3):238-241. Epub 2019 Jan 16.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Primary cutaneous Ewing sarcoma is a rare clinical presentation of Ewing sarcoma, usually occurring as a small, localized tumor on the extremities of young adults and associated with favorable prognosis. We report a case of primary cutaneous Ewing sarcoma, which presented on the sole of the foot of a 27-year-old patient with relapsed acute myeloid leukemia and neutropenia. Diagnosis was determined through histological features and staining, as well as fluorescence in situ hybridization and molecular testing. Read More

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http://dx.doi.org/10.1111/cup.13406DOI Listing
March 2019
3 Reads

Merkel cell carcinoma arising in association with cutaneous T-cell lymphoma: A potential diagnostic pitfall.

J Cutan Pathol 2019 Mar 4;46(3):199-203. Epub 2019 Jan 4.

Department of Pathology, Michigan Medicine, Ann Arbor, Michigan.

Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma with increased prevalence in patients with immunosuppression or B-cell neoplasms. To the best of our knowledge, an association with cutaneous T-cell lymphoma (CTCL) has not been previously described. In this report, we present two cases of MCC arising in the setting of CTCL. Read More

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http://dx.doi.org/10.1111/cup.13404DOI Listing
March 2019
3 Reads

Follicular induction and CK20+ Merkel cells overlying cutaneous focal mucinosis.

J Cutan Pathol 2019 Mar 14;46(3):195-198. Epub 2019 Jan 14.

Department of Dermatology, Division of Dermatopathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Cutaneous focal mucinosis (CFM) or focal dermal mucinosis is a benign reactive process categorized as a primary mucinosis. Skin biopsy is essential for diagnosis, as the clinical appearance is often non-specific. Follicular induction is a phenomenon whereby the epidermis is induced by an underlying process to form primitive or mature hair follicles, and is commonly seen overlying dermatofibromas. Read More

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http://dx.doi.org/10.1111/cup.13402DOI Listing
March 2019
6 Reads

NRAS Q61R and BRAF G466A mutations in atypical melanocytic lesions newly arising in advanced melanoma patients treated with vemurafenib.

J Cutan Pathol 2019 Mar 27;46(3):190-194. Epub 2018 Dec 27.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Background: BRAF inhibition has improved overall survival in patients with BRAF mutant melanoma, but this is associated with a range of known and predictable cutaneous side effects, including squamous cell carcinomas associated with RAS mutations.

Methods: We identified three severely dysplastic nevi, one atypical intraepidermal melanocytic proliferation, and four melanoma in situ lesions, newly arising in four patients undergoing treatment with vemurafenib. To characterize mutations in these atypical melanocytic lesions, we used a custom iPlex panel detecting 74 mutations in 13 genes known to play a role in melanoma pathogenesis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13401
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http://dx.doi.org/10.1111/cup.13401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367041PMC
March 2019
26 Reads

Double-positive CD8/CD4 primary cutaneous acral T-cell lymphoma.

J Cutan Pathol 2019 Mar 4;46(3):231-233. Epub 2019 Jan 4.

Department of Dermatology, Venerology and Allergology, University Medical Center Graz, Graz, Austria.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13403
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http://dx.doi.org/10.1111/cup.13403DOI Listing
March 2019
4 Reads

A diagnostically-challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23-gene expression signature (myPath melanoma).

J Cutan Pathol 2019 Mar 26;46(3):226-230. Epub 2018 Dec 26.

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

Melanoma ex blue nevus (MEBN) is a rare, aggressive, and potentially lethal neoplasm. Distinguishing MEBN from an atypical cellular blue nevus can be very challenging. We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hybridization were used to arrive at the correct diagnosis. Read More

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http://doi.wiley.com/10.1111/cup.13400
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http://dx.doi.org/10.1111/cup.13400DOI Listing
March 2019
7 Reads

Primary cutaneous vs secondary cutaneous follicular lymphomas: A comparative study focused on BCL2, CD10, and t(14;18) expression.

J Cutan Pathol 2019 Mar 26;46(3):182-189. Epub 2018 Dec 26.

Department of Dermatology, Hospital del Mar. Parc de Salut Mar. IMIM, Barcelona, Spain.

Background: Primary cutaneous follicular center-cell lymphoma (PCFCL) is one of the most common types of cutaneous B-cell lymphoma. Differences in immunohistochemical expression of BCL2 and CD10 antigens along with the presence of t(14:18) translocation in neoplastic cells have been postulated as relevant clues in differentiating PCFCL from cutaneous lesions secondary to a systemic follicular lymphoma (SCFL). The aim of this study is to evaluate the significance and usefulness of these parameters in a large series of patients. Read More

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http://dx.doi.org/10.1111/cup.13399DOI Listing
March 2019
14 Reads

A case of multinucleate cell angiohistiocytoma in a 14-year-old boy showing two different clinical and histopathological findings.

J Cutan Pathol 2019 Mar 26;46(3):221-225. Epub 2018 Dec 26.

Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.

Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on the acral regions, such as the face and the distal arms and legs. It affects elderly women more than men and rarely occurs at a young age. The exact pathogenic mechanism of MCAH is not yet clearly understood. Read More

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http://doi.wiley.com/10.1111/cup.13398
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http://dx.doi.org/10.1111/cup.13398DOI Listing
March 2019
13 Reads

Disseminated trichosporonosis with atypical histologic findings in a patient with acute lymphocytic leukemia.

J Cutan Pathol 2019 Feb 18;46(2):159-161. Epub 2018 Dec 18.

Department of Dermatology, Columbia University Medical Center, New York, New York.

We report a case of disseminated Trichosporon asahii in a patient on systemic antifungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid-Schiff and Gomori methenamine silver confirmed the clinical diagnosis. This case highlights the importance of maintaining suspicion for trichosporonosis and contextualizing histologic findings within the underlying clinical picture. Read More

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http://dx.doi.org/10.1111/cup.13397DOI Listing
February 2019
1 Read

Leukoderma induced by rhododendrol is different from leukoderma of vitiligo in pathogenesis: A novel comparative morphological study.

J Cutan Pathol 2019 Feb 18;46(2):123-129. Epub 2018 Dec 18.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan.

Background: Rhododendrol (rhododenol), an inhibitor of tyrosinase activity, is used as a skin-whitening component. Many cases of leukoderma after the application have been reported, termed rhododenol-induced leukoderma (RIL). The aim of this study was to clarify the pathogenesis of RIL morphologically through comparison with vitiligo. Read More

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http://dx.doi.org/10.1111/cup.13396DOI Listing
February 2019
14 Reads

High concordance of BRAF mutational status in matched primary and metastatic melanoma.

J Cutan Pathol 2019 Feb 17;46(2):117-122. Epub 2018 Dec 17.

Department of Pathology, Cork University Hospital, Cork, Ireland.

Background: Techniques for the accurate identification of activating mutations of BRAF in metastatic melanoma are of great clinical importance, due to the availability of targeted therapies for these tumors. There is uncertainty regarding the frequency with which BRAF status differs between primary and metastatic sites.

Methods: Between 2011 and 2016, 219 melanoma cases underwent BRAF testing in our institution. Read More

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http://dx.doi.org/10.1111/cup.13393DOI Listing
February 2019

Neutrophilic figurate erythema of infancy: A diagnostic challenge.

J Cutan Pathol 2019 Mar 26;46(3):216-220. Epub 2018 Dec 26.

Department of Pathology, Duke University, Durham, North Carolina.

Neutrophilic figurate erythema of infancy (NFEI) is a rare variant of annular erythema of infancy. It is characterized by annular erythematous plaques, occasionally with a polycyclic configuration. The main challenge is to differentiate this rare entity from other figurate erythemas associated with serious diseases such as neonatal lupus erythematosus. Read More

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http://doi.wiley.com/10.1111/cup.13394
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http://dx.doi.org/10.1111/cup.13394DOI Listing
March 2019
15 Reads

Lupus erythematosus mimicking mycosis fungoides: CD123 plasmacytoid dendritic cells as a useful diagnostic clue.

J Cutan Pathol 2019 Feb 17;46(2):167-170. Epub 2018 Dec 17.

Universidade de Lisboa, Faculdade de Medicina, Clínica Universitária de Dermatologia de Lisboa, Portugal.

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http://doi.wiley.com/10.1111/cup.13395
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http://dx.doi.org/10.1111/cup.13395DOI Listing
February 2019
8 Reads

Early invasive squamous cell carcinoma recurrence rates: A study examining surgical margins, tumor surface diameter, invasion depth, and grade of differentiation in 1296 cases over 9 years.

J Cutan Pathol 2019 Feb 12;46(2):111-116. Epub 2018 Dec 12.

The Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.

Background: Invasive squamous cell carcinoma (SCC) is typically treated by surgical excision.

Methods: Consecutive SCC excisions were reviewed prospectively in a single Australian center from 2009 to 2017. Cases were examined for recurrence by histopathologic margins, microscopic tumor surface diameter, invasion depth, grade of differentiation, and anatomic site. Read More

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http://doi.wiley.com/10.1111/cup.13392
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http://dx.doi.org/10.1111/cup.13392DOI Listing
February 2019
8 Reads