48,502 results match your criteria Journal of Crohn's & colitis[Journal]


A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice.

Sci Immunol 2019 Apr;4(34)

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Bacterial dysbiosis is associated with Crohn's disease (CD), a chronic intestinal inflammatory disorder thought to result from an abnormal immune response against intestinal bacteria in genetically susceptible individuals. However, it is unclear whether dysbiosis is a cause or consequence of intestinal inflammation and whether overall dysbiosis or specific bacteria trigger the disease. Here, we show that the combined deficiency of NOD2 and phagocyte NADPH oxidase, two CD susceptibility genes, triggers early-onset spontaneous T1-type intestinal inflammation in mice with the pathological hallmarks of CD. Read More

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http://dx.doi.org/10.1126/sciimmunol.aaw4341DOI Listing

Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Pediatrics, Division of Neonatology, University of Oklahoma Health Sciences Center, 1200 North Everett Drive, ETNP7504, Oklahoma City, OK 73104, USA.

Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of these related diseases is currently incomplete, each of these conditions is thought to involve a dysfunctional, or overstated, host immunological response to both bacteria and dietary antigens, resulting in unchecked intestinal inflammation and, often, alterations in the intestinal microbiome. This inflammation can result in an impaired intestinal barrier allowing for bacterial translocation, potentially resulting in systemic inflammation and, in severe cases, sepsis. Read More

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http://dx.doi.org/10.3390/ijms20081912DOI Listing

Systematic Analysis of the Impact of Diagnostic Delay on Bowel Damage in Paediatric Versus Adult Onset Crohn's Disease.

J Crohns Colitis 2019 Apr 19. Epub 2019 Apr 19.

Division of Paediatric Gastroenterology, Centre Hospitalier Universitaire Vaudois [CHUV] and University of Lausanne, Lausanne, Switzerland.

Background And Aims: Length of diagnostic delay is associated with bowel strictures and intestinal surgery in adult patients with Crohn's disease [CD]. Here we assessed whether diagnostic delay similarly impacts on the natural history of paediatric CD patients.

Methods: Data from the Swiss IBD Cohort Study were analysed. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz065DOI Listing

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease.

PLoS One 2019 19;14(4):e0215033. Epub 2019 Apr 19.

Computational Biology, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.

Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH). EETs have pleiotropic effects, including anti-inflammatory activity. Using a Connectivity Map (CMAP) approach, we identified an inverse-correlation between an exemplar EPHX2 inhibitor (EPHX2i) compound response and an inflammatory bowel disease patient-derived signature. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215033PLOS

Medicinal Sulphur Polypore Mushroom Laetiporus sulphureus (Agaricomycetes) Plus Tiny Amounts of Essential Oils Decrease the Activity of Crohn Disease.

Int J Med Mushrooms 2019 ;21(3):267-273

Clinical Research, Medicine Information Formation, Cormontreuil, France.

A mixture of Laetiporus sulphureus (LS) and essential oils of Origanum vulgare, Cinnamomum verum, and Syzygium aromaticum (LOCS) was recommended for 24 patients with Crohn disease (CD). Patients were followed up for at least 24 months (median 32 months; range, 24-54 months). Nineteen patients were compliant with the treatment, although 3 stopped taking it, relapsed, began the LOCS regimen again, and recovered; 5 patients were not compliant at all. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030122DOI Listing
January 2019

Systematic review: components of a comprehensive geriatric assessment in inflammatory bowel disease - a potentially promising but often neglected risk stratification.

J Crohns Colitis 2019 Apr 19. Epub 2019 Apr 19.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

Background: The population of older patients with inflammatory bowel disease (IBD) is increasing. Patient age does not fully account for poor outcomes and its clinical utility for risk stratification is limited. Comprehensive Geriatric Assessment (CGA), comprising a somatic, functional, mental and social assessment or frailty, could be a predictor tool. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz082DOI Listing

Differential miRNA expression in ileal and colonic tissues reveals an altered immunoregulatory molecular profile in individuals with Crohn's disease versus healthy subjects.

J Crohns Colitis 2019 Apr 19. Epub 2019 Apr 19.

Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, Canada.

MicroRNAs (miRNAs) are key modulators of gene expression in Crohn's disease (CD) and may drive tissue-specific molecular alterations underlying CD susceptibility. In this study we analysed differential miRNA expression between CD and healthy subjects across ileal and colonic tissues. A cohort of CD and healthy control (HC) subjects was recruited and clinical data collected. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz076DOI Listing

Multiple Epistasis Interactions Within MHC Are Associated With Ulcerative Colitis.

Front Genet 2019 3;10:257. Epub 2019 Apr 3.

The Children's Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, PA, United States.

Successful searching for epistasis is much challenging, which generally requires very large sample sizes and/or very dense marker information. We exploited the largest Crohn's disease (CD) dataset (18,000 cases + 34,000 controls) and ulcerative colitis (UC) dataset (14,000 cases + 34,000 controls) to date. Leveraging its dense marker information and the large sample size of this IBD dataset, we employed a two-step approach to exhaustively search for epistasis. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2019.00257
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http://dx.doi.org/10.3389/fgene.2019.00257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456704PMC
April 2019
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The mathematics of Crohn disease.

Authors:
Suzanne Edison

CMAJ 2018 Sep;190(38):E1143

Seattle, Wash.

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http://dx.doi.org/10.1503/cmaj.180764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157494PMC
September 2018

Usefulness of Ustekinumab for Treating a Case of Myelodysplastic Syndrome-Associated Inflammatory Bowel Disease.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Autoimmune diseases including inflammatory bowel disease (IBD) occur in association with myelodysplastic syndrome (MDS). MDS-associated IBD frequently demonstrates a complicated course. We herein report the first case with MDS-associated IBD that was successfully treated with ustekinumab (UST), an anti-interleukin (IL) 12/23p40 monoclonal antibody. Read More

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http://dx.doi.org/10.2169/internalmedicine.2495-18DOI Listing
April 2019
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Non-invasive Multi-modal Methods to Differentiate Inflamed vs Fibrotic Strictures in Patients With Crohn's Disease.

Clin Gastroenterol Hepatol 2019 Apr 14. Epub 2019 Apr 14.

IBD Centre, Humanitas Clinical and Research Centre, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy. Electronic address:

Fibrotic strictures occur in 30% of patients with Crohn's disease (CD). However, there are no therapeutic agents that prevent or reverse fibrotic strictures. Strictures are treated by endoscopic dilatation procedures and surgical procedures, but there are high rates of recurrence. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.025DOI Listing

The renin-angiotensin system promotes colonic inflammation by inducing T17 activation via the JAK2/STAT pathway.

Am J Physiol Gastrointest Liver Physiol 2019 Apr 17. Epub 2019 Apr 17.

Medicine, The University of Chicago, United States.

Previous studies suggest that the renin-angiotensin system (RAS) is pathogenic factor for colitis. The goal of this study was to elucidate the molecular mechanism whereby angiotensin II (Ang II) promotes colonic inflammation. We found that renin was highly induced in colonic biopsies from patients with ulcerative colitis or Crohn's disease, and colonic renin and Ang II levels were markedly increased in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis model, indicating that the colonic RAS is activated in colitis. Read More

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http://dx.doi.org/10.1152/ajpgi.00053.2019DOI Listing

Serum Levels of Infliximab and Anti-Infliximab Antibodies in Brazilian Patients with Crohn's Disease.

Clinics (Sao Paulo) 2019 04 8;74:e824. Epub 2019 Apr 8.

Laboratorio de Investigacao em Doencas Inflamatorias Intestinais, Servico de Coloproctologia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, BR.

Objectives: The aim of this study was to evaluate the quantitative serum level of infliximab (IFX) as well as the detection of anti-infliximab antibodies (ATIs) in patients with Crohn's disease (CD).

Method: Forty patients with CD under treatment at a tertiary center in southeastern Brazil were evaluated. Their use of infliximab was continuous and regular. Read More

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http://dx.doi.org/10.6061/clinics/2019/e824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445154PMC

Fecal Lactoferrin for Assessment of Inflammatory Bowel Disease Activity: A Systematic Review and Meta-Analysis.

J Clin Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China.

Objective: Persistent disease activity is associated with a poor prognosis in inflammatory bowel disease (IBD) patients. Therefore, monitoring of IBD activity can avoid the poor prognosis. Serum biomarkers reflect a summation of systemic host responses rather than being specific for intestinal inflammation. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001212DOI Listing

Selective use of cystogram following segmental bowel resection in patients with enterovesical fistula.

Colorectal Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands.

Introduction: Patients undergoing resectional surgery for enterovesical fistulas generally have an in-dwelling urinary catheter postoperatively to prevent a recurrent fistula. The aim of this study was to assess the place of a postoperative cystogram after such surgery, when it should be performed and for how long the bladder should be drained after surgery.

Methods: A retrospective single centre study of all patients undergoing ileocaecal or sigmoid resection for surgery for enterovesical fistula with the primary endpoint of recurrent urinary fistula. Read More

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http://dx.doi.org/10.1111/codi.14652DOI Listing

Real-life effectiveness of ustekinumab in inflammatory bowel disease patients with concomitant psoriasis or psoriatic arthritis: An IG-IBD study.

Dig Liver Dis 2019 Apr 13. Epub 2019 Apr 13.

IBD Unit, Presidio Columbus, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address:

Background: Few data exist regarding the effectiveness of ustekinumab in inflammatory bowel disease (IBD) patients treated for concomitant psoriasis or psoriatic arthritis.

Aims: to describe the outcomes of IBD patients who received subcutaneous ustekinumab through a dermatological or rheumatological prescription.

Methods: This multicenter, retrospective study included all IBD patients who were started on ustekinumab for concomitant active psoriasis/ psoriatic arthritis, irrespective of IBD activity. Read More

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http://dx.doi.org/10.1016/j.dld.2019.03.007DOI Listing
April 2019
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Clinical Ultrasound in Inflammatory Bowel Disease.

Ultraschall Med 2019 Apr 16;40(2):132-162. Epub 2019 Apr 16.

Internal Medicine, Städtisches Klinikum Lüneburg gGmbH, Lüneburg, Germany.

Ultrasound should be the first-line imaging method in the medical care of patients with inflammatory bowel disease. It can be used to differentiate between Crohn's disease and ulcerative colitis and to detect numerous complications like stenoses, fistulas, and abscesses. As the method is also highly suitable for follow-up, stressful endoscopic procedures and examinations involving radiation are less necessary. Read More

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http://dx.doi.org/10.1055/a-0869-8799DOI Listing
April 2019
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Citrus fruits and their flavonoids in inflammatory bowel disease: an overview.

Nat Prod Res 2019 Apr 16:1-15. Epub 2019 Apr 16.

a Department of Chemical, Biological, Pharmaceutical and Environmental Sciences , University of Messina , Messina , Italy.

Inflammatory bowel disease (IBD), with its major manifestations being Crohn's disease and ulcerative colitis, belongs to the gastrointestinal inflammatory disorders, whose main therapeutic approach is represented by synthetic anti-inflammatory drugs. However, they are often accompanied by many side effects that shifted the interest of the scientific community towards natural products. In this context, several studies asserted the anti-IBD effects of Citrus fruits and their flavonoids, thus the aim of the present review is to provide robust evidence favouring their role in the prevention and treatment of IBD. Read More

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https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1
Publisher Site
http://dx.doi.org/10.1080/14786419.2019.1601196DOI Listing
April 2019
2 Reads

Teduglutide in Patients With Active Crohn's Disease and Short Bowel Syndrome.

Inflamm Bowel Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1093/ibd/izz087DOI Listing
April 2019
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4.464 Impact Factor

Interrelations of Apoptotic and Cellular Senescence Genes Methylation in Inflammatory Bowel Disease Subtypes and Colorectal Carcinoma in Egyptians Patients.

Appl Biochem Biotechnol 2019 Apr 15. Epub 2019 Apr 15.

Students at Faculty of Medicine, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Ras-related domain family member 1 transcript variant A (RASSF1A) controls apoptosis and cell proliferation while p14/ARF gene has a regulatory role in cellular senescence. Failure of apoptosis and cellular senescence occurs during inflammatory bowel disease (IBD) and colorectal cancer (CRC). To reveal the role of peripheral leukocyte promoter methylation of RASSF1A and p14/ARF in the pathogenesis of IBD subtypes and CRC we investigated the methylation state of the two genes by methylation-specific polymerase chain reaction (MSP-PCR) in 60 CRC patients, 60 patients with IBD; 27 with ulcerative colitis and 33 had Crohn's disease and also in 30 healthy subjects. Read More

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http://link.springer.com/10.1007/s12010-019-03017-x
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http://dx.doi.org/10.1007/s12010-019-03017-xDOI Listing
April 2019
2 Reads

Is Parkinson's disease a chronic low-grade inflammatory bowel disease?

J Neurol 2019 Apr 12. Epub 2019 Apr 12.

Inserm, U1235, 1 rue Gaston Veil, 44035, Nantes, France.

While the pathogenesis of Parkinson's disease is not fully understood, there is increasing evidence that inflammatory responses in the brain are implicated in both disease initiation and progression. The inflammatory process in Parkinson's disease is, however, not limited to the brain but also involves the gastrointestinal tract. High amounts of cytokines and inflammatory markers are found in the colon of Parkinson's disease patients and there is now strong epidemiological and genetical evidence linking Parkinson's disease to inflammatory bowel diseases. Read More

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http://dx.doi.org/10.1007/s00415-019-09321-0DOI Listing
April 2019
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Long-term clinical effectiveness of ustekinumab in patients with Crohn's disease who failed biological therapies: a national cohort study.

J Crohns Colitis 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.

Background: Ustekinumab (UST) was recently approved in Europe for the treatment of moderate to severe Crohn's disease (CD). Long-term real-world data are currently scarce in CD patients previously exposed to several biologics.

Methods: This is an observational, national, retrospective multicenter study. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz080DOI Listing

A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong District of Seoul, Korea in 1986-2015.

J Crohns Colitis 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background And Aims: Although the incidence of inflammatory bowel disease (IBD) is increasing in Asia, data on long-term epidemiologic trends are limited. We performed a 30-year longitudinal study to investigate temporal trends in the epidemiology of Crohn's disease (CD) and ulcerative colitis (UC) in Seoul, Korea.

Methods: This population-based study included 1431 IBD patients (418 CD, 1013 UC) diagnosed between 1986 and 2015 in the Songpa-Kangdong district of Seoul, Korea. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz081DOI Listing
April 2019
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Cohort profile of the PRoteomic Evaluation and Discovery in an IBD Cohort of Tri-service Subjects (PREDICTS) study: Rationale, organization, design, and baseline characteristics.

Contemp Clin Trials Commun 2019 Jun 26;14:100345. Epub 2019 Mar 26.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Purpose: The etiology of Inflammatory Bowel Disease (IBD) remains currently unknown but evidence would suggest that it results from a complex interplay between genetic susceptibility genes, the intestinal microbiome and the environment, resulting in an increased response towards microbial and self-antigens, followed by the development of pre-clinical intestinal inflammation as a precursor to overt clinical disease. Efforts are needed to provide insights into the characterization of the disease, the possible prediction of complications, and the detection of a pre-clinical disease state where, through early screening and intervention, disease course can be reversed, attenuated or even prevented. A consortium of academic, industry and governmental organization investigators initiated this study to enable an assessment of pre-disease biomarkers in patients newly diagnosed with Crohn's disease (CD) and ulcerative colitis (UC). Read More

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http://dx.doi.org/10.1016/j.conctc.2019.100345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446072PMC
June 2019
1 Read

Immune regulation mechanism of vitamin D level and IL-17/IL-17R pathway in Crohn's disease.

Exp Ther Med 2019 May 13;17(5):3423-3428. Epub 2019 Mar 13.

Department of Gastroenterology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan 471000, P.R. China.

Immune regulation mechanism of vitamin D level and interleukin (IL)-17/IL-17 receptor (IL-17R) pathway in Crohn's disease was studied. Of 40 clean mature healthy rats, 10 rats were used as control group based on random number table, the remaining 30 rats to establish Crohn's disease rat models. After successful modeling, 30 rats were divided into model group, low-dose group and high-dose group with random number table. Read More

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http://dx.doi.org/10.3892/etm.2019.7389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447769PMC

Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants.

Genes (Basel) 2019 Apr 4;10(4). Epub 2019 Apr 4.

Institute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, Italy.

The contribution of candidate genetic variants involved in azathioprine biotransformation on azathioprine efficacy and pharmacokinetics in 111 young patients with inflammatory bowel disease was evaluated. Azathioprine doses, metabolites thioguanine-nucleotides (TGN) and methylmercaptopurine-nucleotides (MMPN) and clinical effects were assessed after at least 3 months of therapy. Clinical efficacy was defined as disease activity score below 10. Read More

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http://dx.doi.org/10.3390/genes10040277DOI Listing
April 2019
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Nonenzymatic Serum Antioxidant Capacity in IBD and Its Association with the Severity of Bowel Inflammation and Corticosteroids Treatment.

Medicina (Kaunas) 2019 Apr 2;55(4). Epub 2019 Apr 2.

Department of Medical Biochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.

: Oxidative stress signalling plays a monumental role in inflammatory bowel disease (IBD). Reduction of oxidative stress might control inflammation, block tissue damage, and reverse natural history of IBD. We assessed the serum concentrations of free thiols (FT) and uric acid (SUA), together constituting a large part of nonenzymatic serum antioxidant capacity, as well as total antioxidant status (TAS) with reference to IBD phenotype, activity, co-occurrence of anemia, and treatment with azathioprine (AZA) and corticosteroids (CS). Read More

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http://dx.doi.org/10.3390/medicina55040088DOI Listing
April 2019
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Fat Grafting for Improved Ileostomy Ostomy Device Fit: A Case Report.

Wound Manag Prev 2019 Mar;65(3):38-44

University of Pittsburgh Medical Center, Pittsburgh, PA.

For patients with an ostomy, a poor fitting appliance may cause leakage, peristomal dermatitis, and frequent appliance changes.

Purpose: The purpose of this case study was to report the outcome of fat grafting to augment peristomal soft tissue and improve appliance fit.

Case Study: A 57-year-old woman with a history of Crohn's disease presented with soft-tissue deficiency and uneven contour around her ileostomy site. Read More

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March 2019
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The central role of psychopathology and its association with disease severity in inflammatory bowel disease and irritable bowel syndrome.

Riv Psichiatr 2019 Mar-Apr;54(2):75-83

Department of Internal Medicine and Medical Specialties, Policlinico Umberto I, Sapienza University of Rome, Italy - Department of Gastroenterology, Humanitas Clinical Institute, Rozzano (Milan), Italy.

Background: Biopsychosocial models for both organic and functional gastrointestinal (GI) disorders can be found in the literature. To clarify the role of psychopathological factors and their relationship with GI symptom severity, several studies have examined them in inflammatory bowel disease (IBD) - occasionally distinguishing between ulcerative colitis (UC) and Crohn's disease (CD) - and in irritable bowel syndrome (IBS), leading to unclear results.

Aims: We aimed to evaluate the psychopathological features of IBD and IBS patients in comparison with healthy individuals and assess the association with disease severity. Read More

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http://dx.doi.org/10.1708/3142.31248DOI Listing
April 2019
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Influence of previous corticosteroid treatment on the efficacy and safety of infliximab therapy in Crohn disease.

Medicine (Baltimore) 2019 Apr;98(15):e15189

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

To determine the effect of prior corticosteroid treatment on the results of infliximab (IFX) therapy in patients with Crohn disease (CD).Patients with CD treated with at least 3 IFX infusions between March 2009 and April 2017 were divided into steroid group (n = 43) and nonsteroid group (n = 22) and analyzed retrospectively.The cumulative probabilities of clinical remission and response to IFX at weeks 14, 30, 54, and 78 were higher in the steroid group, though this difference was not statistical significant. Read More

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http://dx.doi.org/10.1097/MD.0000000000015189DOI Listing
April 2019
2 Reads

Serum vitamin D but not zinc levels are associated with different disease activity status in patients with inflammatory bowel disease.

Medicine (Baltimore) 2019 Apr;98(15):e15172

University Medical Center Göttingen, Department of Gastroenterology and Gastrointestinal Oncology, Robert- Koch-Str., Göttingen, Germany.

The incidence of inflammatory bowel disease (IBD) is increasing and the pathogenesis is still not completely understood. Micronutrients like vitamin D [25 (OH)D] and zinc play an important role in enzyme activities and the immune system. As the 25 (OH)D-receptor has been shown to be downregulated in patients with IBD, 25 (OH)D may emerge as a predictive marker for disease improvement. Read More

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http://dx.doi.org/10.1097/MD.0000000000015172DOI Listing
April 2019
2 Reads

Traditional Chinese medicine for management of recurrent and refractory Crohn disease: A case report.

Medicine (Baltimore) 2019 Apr;98(15):e15148

Department of Thyroid.

Introduction: Crohn disease (CD) is a chronic relapsing systemic inflammatory disease afflicting the gastrointestinal system with a high morbidity. There has been increasing clinical interest in traditional Chinese medicine (TCM) treatment for CD. This report aims to present patient outcome of therapeutic management using TCM in combination with pharmacologic therapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000015148DOI Listing
April 2019
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Assessing mental health and the relation with variables of demographic and clinical in Crohn's disease patients; 2016-2017.

J Family Med Prim Care 2019 Feb;8(2):728-732

Department of Psychiatry, School of Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.

Background: Crohn's disease is a group of special diseases that are considered in psychiatric studies because there is a contrast between the physical and psychological diseases among the affected patients.

Aim: The aim of this study was assessing mental health and the relation with variables of demographic and clinical in Crohn's disease patients.

Methods: In this epidemiological study, 96 patients with Crohn's disease who referred to educational hospitals in Ahvaz during 2016--2017 were evaluated by demographic and clinical questionnaires and SCL-90 questionnaires for mental health, and the information was analyzed by SPSS software version 22. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_236_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436295PMC
February 2019
2 Reads

Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease.

Front Pharmacol 2019 29;10:305. Epub 2019 Mar 29.

Department of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.

Several molecular technologies aimed at regulating gene expression that have been recently developed as a strategy to combat inflammatory and neoplastic diseases. Among these, antisense technology is a specific, rapid, and potentially high-throughput approach for inhibiting gene expression through recognition of cellular RNAs. Advances in the understanding of the molecular mechanisms that drive tissue damage in different inflammatory diseases, including Crohn's disease (CD) and ulcerative colitis (UC), the two major inflammatory bowel diseases (IBDs) in humans, have facilitated the identification of novel druggable targets and offered interesting therapeutic perspectives for the treatment of patients. Read More

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http://dx.doi.org/10.3389/fphar.2019.00305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450224PMC
March 2019
2 Reads

A 30-year follow-up study of patients with Melkersson-Rosenthal syndrome shows an association to inflammatory bowel disease.

Ann Med 2019 Apr 13:1-7. Epub 2019 Apr 13.

a Department of Otorhinolaryngology, Head and Neck Surgery , Helsinki University Hospital and University of Helsinki , Helsinki , Finland.

Background: Melkersson-Rosenthal syndrome (MRS) is often classified under the term orofacial granulomatosis (OFG). A part of OFG patients eventually develop Crohn's disease (CD), but the relationship between MRS and CD is unknown.

Goals: To evaluate the long-term outcomes of MRS patients, with specific interest in bowel-related symptoms. Read More

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http://dx.doi.org/10.1080/07853890.2019.1591634DOI Listing
April 2019
1 Read

Aberrant brain structural large-scale connectome in Crohn's disease.

Neurogastroenterol Motil 2019 Apr 14:e13593. Epub 2019 Apr 14.

Center for Mental Health, Odenwald District Healthcare Centre, Erbach, Germany.

Background: Disturbed brain-gut interactions and a bidirectional relationship between inflammation and psychiatric symptoms such as anxiety and depression are being discussed in patients with inflammatory bowel diseases (IBD). Alterations of brain structure and function in IBD have been reported with heterogeneous results. Whether these changes reflect independent localized deficits or rather a systematic disruption in the anatomical organization of large-scale brain networks remains unclear. Read More

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http://dx.doi.org/10.1111/nmo.13593DOI Listing

Evaluation of optimal biopsy location for assessment of histological activity, transcriptomic and immunohistochemical analyses in patients with active Crohn's disease.

Aliment Pharmacol Ther 2019 Apr 15. Epub 2019 Apr 15.

Robarts Clinical Trials Inc, London, ON, Canada.

Background: The appropriate location for biopsy procurement relative to an ulcer in active Crohn's disease is unknown.

Aim: To explore the relationship between biopsy location, histological disease activity, proinflammatory gene expression and the presence of inflammatory cells.

Methods: Fifty-one patients with Crohn's disease and ulcers >0. Read More

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http://dx.doi.org/10.1111/apt.15250DOI Listing

Infant milk-feeding practices and diagnosed celiac disease and inflammatory bowel disease in offspring: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):838S-851S

Food and Nutrition Service, USDA, Alexandria, VA.

Background: During the Pregnancy and Birth to 24 Months Project, the USDA and US Department of Health and Human Services initiated an evidence review on diet and health in these populations.

Objective: The aim of these systematic reviews was to examine the relationships of never versus ever feeding human milk, shorter versus longer durations of any and exclusive human milk feeding, and feeding a lower versus a higher intensity of human milk to mixed-fed infants with diagnosed celiac disease and inflammatory bowel disease (IBD).

Methods: The Nutrition Evidence Systematic Review team (formerly called the Nutrition Evidence Library) conducted systematic reviews with external experts. Read More

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https://academic.oup.com/ajcn/article/109/Supplement_7/838S/
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http://dx.doi.org/10.1093/ajcn/nqy371DOI Listing
March 2019
2 Reads
6.770 Impact Factor

Therapeutic Efficacy and Adverse Events of Tacrolimus in Patients with Crohn's Disease: Systematic Review and Meta-Analysis.

Dig Dis Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Minami 1-jo Nishi 16-chome, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.

Background: Only a few randomized controlled trials (RCTs) and some uncontrolled trials have reported the efficacy and adverse events (AEs) of tacrolimus (Tac) in patients with refractory Crohn's disease (CD). The aim of this study was to undertake a systematic review and meta-analysis of the therapeutic efficacy and AEs of Tac in patients with CD.

Methods: We investigated studies reporting the therapeutic efficacy of Tac in patients with CD from 1950 until December 2017. Read More

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http://dx.doi.org/10.1007/s10620-019-05619-1DOI Listing

Pathogenesis of fibrostenosing Crohn's disease.

Transl Res 2019 Mar 26. Epub 2019 Mar 26.

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio; Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

Crohn's disease (CD) is a chronic inflammatory disease, which could affect any part of the gastrointestinal tract. A severe complication of CD is fibrosis-associated strictures, which can cause bowel obstruction. Unfortunately, there is no specific antifibrotic therapy available. Read More

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http://dx.doi.org/10.1016/j.trsl.2019.03.005DOI Listing
March 2019
3 Reads

Mechanisms of microbial pathogenesis and the role of the skin microbiome in psoriasis: A review.

Clin Dermatol 2019 Mar - Apr;37(2):160-166. Epub 2019 Jan 16.

Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA; Departments of Pathology and Social Sciences & Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

The pathogenesis of psoriasis may involve a breakdown of immune tolerance to cutaneous microorganisms. Psoriasis is associated with a higher incidence of Crohn disease and periodontitis, two diseases involving impaired tolerance and abnormal immune activation in response to intestinal and oral microbiota, respectively. In addition, guttate and chronic plaque psoriasis are associated with Streptococcus pyogenes colonization. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.01.011DOI Listing
January 2019
2 Reads

Development and Validation of the Mucosal Inflammation Non-invasive Index For Pediatric Crohn's Disease.

Clin Gastroenterol Hepatol 2019 Apr 10. Epub 2019 Apr 10.

Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel. Electronic address:

Background & Aims: Mucosal healing (MH) has become a goal of therapy for Crohn's disease (CD), but frequent endoscopies are not feasible. We aimed to develop and validate a non-invasive index to assess mucosal inflammation in children with CD.

Methods: We collected data from the multi-center prospective ImageKids study, in which children with CD underwent ileocolonoscopy with magnetic resonance enterography. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.012DOI Listing
April 2019
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Clock Gene Disruption is an Initial Manifestation of Inflammatory Bowel Disease.

Clin Gastroenterol Hepatol 2019 Apr 10. Epub 2019 Apr 10.

Institute of Biochemistry, Food Science and Nutrition, the Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot, Israel. Electronic address:

Background & Aims: Sleep disruption modifies the immune system and can trigger flares of inflammatory bowel diseases (IBD). Changes in expression of clock genes have been reported in patients with IBD. We investigated whether a change in the circadian clock is an early event in development of IBD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193037
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http://dx.doi.org/10.1016/j.cgh.2019.04.013DOI Listing
April 2019
2 Reads

Tacrolimus Therapy in Steroid-Refractory Ulcerative Colitis: A Review.

Inflamm Bowel Dis 2019 Apr 13. Epub 2019 Apr 13.

Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China.

Inflammatory bowel diseases are known for a chronic inflammatory process of the gastrointestinal tract and include Crohn's disease and ulcerative colitis (UC). Patients who are dependent on or resistant to corticosteroids account for about 20% of severe UC patients. Tacrolimus is a calcineurin inhibitor that has recently been used in the treatment of steroid-refractory ulcerative colitis. Read More

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https://academic.oup.com/ibdjournal/advance-article/doi/10.1
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http://dx.doi.org/10.1093/ibd/izz068DOI Listing
April 2019
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Endorectal Advancement Flaps for Perianal Fistulae in Crohn's Disease: Careful Patient Selection Leads to Optimal Outcomes.

J Gastrointest Surg 2019 Apr 12. Epub 2019 Apr 12.

UC San Diego Health System, San Diego, CA, USA.

Background: Anorectal fistulae resultant from Crohn's disease (CD) is a clinical challenge. The advent of immune therapy (IT) has altered the way in which fistulae have responded to treatment. Endorectal advancement flap (ERAF) is a surgical procedure that is used to treat complex fistulae. Read More

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http://dx.doi.org/10.1007/s11605-019-04205-0DOI Listing
April 2019
2 Reads

Illuminating an Invisible Epidemic: A Systemic Review of the Clinical and Economic Benefits of Early Diagnosis and Treatment in Inflammatory Disease and Related Syndromes.

J Clin Med 2019 Apr 11;8(4). Epub 2019 Apr 11.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Healthcare expenditures in the United States are growing at an alarming level with the Centers for Medicare and Medicaid Services (CMS) projecting that they will reach $5.7 trillion per year by 2026. Inflammatory diseases and related syndromes are growing in prevalence among Western societies. Read More

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http://dx.doi.org/10.3390/jcm8040493DOI Listing
April 2019
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Identification of suitable reference microRNA for qPCR analysis in pediatric inflammatory bowel disease.

Physiol Genomics 2019 Apr 12. Epub 2019 Apr 12.

Lurie Children's Hospital of Chicago, United States.

Pediatric inflammatory bowel disease (IBD) accounts for 10-15% of IBD and is associated with considerable morbidity for patients. Dysregulated microRNAs (miRNA), small non-coding RNA molecules that modulate gene expression, have been the target of research in IBD diagnosis, surveillance and therapy. Proper selection of reference genes, which are a prerequisite for accurate measurement of miRNA expression, are currently lacking. Read More

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http://dx.doi.org/10.1152/physiolgenomics.00126.2018DOI Listing
April 2019
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Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension with active Crohn's disease.

Surg Case Rep 2019 Apr 11;5(1):59. Epub 2019 Apr 11.

Department of Cardiovascular Surgery, Tokyo Medical University Hospital, 6-7-1, Nishishinjuku, Shinjuju, Tokyo, 160-0023, Japan.

Background: Anticoagulation control in active inflammatory bowel disease (IBD) is challenging because of hypercoagulation and bleeding complications. The strategy for treating chronic thromboembolic pulmonary hypertension (CTEPH) in IBD remains controversial because only a few studies have reported its successful treatment (Kim and Lang. Eur Respir Rev 21: 27-31, 2012, Bonderman, et al. Read More

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http://dx.doi.org/10.1186/s40792-019-0616-7DOI Listing
April 2019
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Effectiveness and safety of the switch from Remicade to CT-P13 in patients with inflammatory bowel disease.

J Crohns Colitis 2019 Apr 12. Epub 2019 Apr 12.

Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid.

Aims: To evaluate the clinical outcomes in patients with IBD after switching from Remicade to CT-P13 in comparison with patients who maintain Remicade .

Methods: Patients under Remicade who were in clinical remission with standard dosage at study entry were included. The switch cohort (SC) comprised patients who made the switch from Remicade to CT-P13, and the "non-switch" cohort (NC) patients kept under Remicade . Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz070DOI Listing