3,418 results match your criteria Journal of Critical Care[Journal]


The hospital-based evaluation of laxative prophylaxis in ICU (HELP-ICU): A pilot cluster-crossover randomized clinical trial.

J Crit Care 2019 Apr 8;52:86-91. Epub 2019 Apr 8.

The University of Melbourne, Melbourne Medical School, Department of Medicine and Radiology, Royal Melbourne Hospital, Parkville, VIC 3050, Australia; Intensive Care Unit, The Royal Melbourne Hospital, Parkville, Victoria, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, Australia; Intensive Care Unit, The Austin Hospital, Heidelberg, Victoria, Australia.

Purpose: Prophylactic laxative regimens may prevent constipation but may increase diarrhea and subsequent rectal tube insertion. Our aim was to compare three prophylactic laxative regimens on the rate of rectal tube insertion (primary outcome) and major constipation- or diarrhea-associated complications.

Material And Methods: We conducted a cluster-crossover trial. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.04.010DOI Listing

Comparison of clinical characteristics and outcomes between homeless and non-homeless patients admitted to intensive care units: An observational propensity-matched cohort study in Korea.

J Crit Care 2019 Apr 3;52:80-85. Epub 2019 Apr 3.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea. Electronic address:

Purpose: To compare clinical characteristics and outcomes between critically ill homeless and non-homeless patients admitted to the intensive care unit (ICU) in a Korea.

Materials And Methods: We retrospectively analyzed the medical charts of homeless and non-homeless patients admitted to ICU at Seoul Boramae Medical Center between January 2012 and December 2017. Patients were selected using 1: 2 propensity score matching including age, sex, and type of ICU and multivariate analyses were performed to determine risk factors for hospital and ICU mortality. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.04.005DOI Listing

Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: A prospective observational study.

J Crit Care 2019 Apr 9;52:75-79. Epub 2019 Apr 9.

Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium. Electronic address:

Purpose: To evaluate target attainment of empirically dosed continuous infusion piperacillin/tazobactam (TZP) and meropenem (MER) in critically ill patients.

Patients And Methods: Patients were sampled on a daily basis. TZP or MER concentrations were evaluated during the first two days antibiotic therapy. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.04.013DOI Listing
April 2019
1 Read

Development and daily use of a numeric rating score to assess sleep quality in ICU patients.

J Crit Care 2019 Apr 6;52:68-74. Epub 2019 Apr 6.

Radboud University Medical Center, Department of Intensive Care Medicine, The Netherlands.

Purpose: Insufficient sleep burdens critically ill patients, optimizing sleep may enhance patient's outcomes. Current assessment methods may unnecessary burden patients. Therefore, a single numeric rating score was validated for sleep assessment. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.04.009DOI Listing
April 2019
2 Reads

Differences in prevalence of ICU protocols between neurologic and non-neurologic patient populations.

J Crit Care 2019 Mar 27;52:63-67. Epub 2019 Mar 27.

Harvard University School of Medicine, Department of Emergency Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, United States.

Purpose: To compare the differences in the presence of protocols aimed at addressing complications for neurologically injured patients vs. non-neurologic injured patients in a large sample of ICUs across the United States.

Materials And Methods: Prospective observational multi-center cohort study. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.03.002DOI Listing

Ischemia-related vascular complications of percutaneously initiated venoarterial extracorporeal membrane oxygenation: Indication setting, risk factors, manifestation and outcome.

J Crit Care 2019 Apr 3;52:58-62. Epub 2019 Apr 3.

Department of Anesthesiology, University Medical Center Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany. Electronic address:

Purpose: Venoarterial (VA) ECMO is widely accepted as salvage therapy for cardio-respiratory or cardiac failure. Vascular complications from cannulation are common and potentially life-threatening. Here, we retrospectively analyzed vascular complications following VA ECMO therapy. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.04.002DOI Listing
April 2019
1 Read

Describing drug and fluid therapy in the paediatric intensive care unit: A pilot study.

J Crit Care 2019 Apr 2;52:53-57. Epub 2019 Apr 2.

Department of Critical Care Medicine, Hospital for Sick Children, Toronto, ON, Canada; Child Health Evaluative Sciences, The Research Institute, Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

Purpose: Care in the paediatric intensive care unit (PICU) involves many clinical activities. The objectives of this study were to evaluate the feasibility of a novel observation method, the reliability of data abstraction, and to report the initial findings from application of this approach.

Materials And Methods: Bedside activities of patients and clinical staff were recorded by direct observational study using video recording and audio annotation. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.04.004DOI Listing
April 2019
3 Reads

Kinetic analysis of cardiac compressions during cardiopulmonary resuscitation.

J Crit Care 2019 Apr 3;52:48-52. Epub 2019 Apr 3.

Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Electronic address:

Purpose: Little is known about the dynamics of cardiac compression during cardiopulmonary resuscitation (CPR). The purpose of this study was to investigate the dynamics of chest compressions by analyzing movement of the right ventricular free wall excursion during CPR.

Materials And Methods: Patients older than 18 years with non-traumatic cardiac arrest who received CPR were enrolled. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.04.003DOI Listing
April 2019
2.191 Impact Factor

The effect of emergency department crowding on lung-protective ventilation utilization for critically ill patients.

J Crit Care 2019 Mar 23;52:40-47. Epub 2019 Mar 23.

Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

Objective: To measure effects of ED crowding on lung-protective ventilation (LPV) utilization in critically ill ED patients.

Methods: This is a retrospective cohort study of adult mechanically ventilated ED patients admitted to the medical intensive care unit (MICU), over a 3.5-year period at a single academic tertiary care hospital. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.03.008DOI Listing
March 2019
1 Read

Bolus therapy with 3% hypertonic saline or 0.9% saline in emergency department patients with suspected sepsis: A pilot randomised controlled trial.

J Crit Care 2019 Mar 28;52:33-39. Epub 2019 Mar 28.

Centre for Clinical Research in Emergency Medicine, Harry Perkins Institute of Medical Research, Perth, Australia; Emergency Medicine, University of Western Australia, Perth, Australia; Emergency Department, Fiona Stanley Hospital, Perth, Australia.

Objective And Design: Hypertonic saline administered during fluid resuscitation may mitigate endothelial glycocalyx (EG) shedding and inflammation. The objective of this pilot randomised controlled trial was to measure the effect of hypertonic saline, compared to isotonic saline, on biomarkers of EG shedding and inflammation in emergency department patients with suspected sepsis.

Methods: Patients received either 5 mL/kg of 3% saline (hypertonic group, n = 34) or 10 mL/kg of 0. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.03.009DOI Listing

Utility of pleural effusion drainage in the ICU: An updated systematic review and META-analysis.

J Crit Care 2019 Mar 19;52:22-32. Epub 2019 Mar 19.

Division of Anesthesia and Intensive Care Medicine, Department of Medicine, University of Udine, P.le S. Maria della Misericordia 15, 33100 Udine, Italy.

Purpose: The effects on the respiratory or hemodynamic function of drainage of pleural effusion on critically ill patients are not completely understood. First outcome was to evaluate the PiO/FiO (P/F) ratio before and after pleural drainage.

Secondary Outcomes: evaluation of A-a gradient, End-Expiratory lung volume (EELV), heart rate (HR), mean arterial pressure (mAP), left ventricular end-diastolic volume (LVEDV), stroke volume (SV), cardiac output (CO), ejection fraction (EF), and E/A waves ratio (E/A). Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.03.007DOI Listing
March 2019
2 Reads

The impact of errors on healthcare professionals in the critical care setting.

J Crit Care 2019 Mar 14;52:16-21. Epub 2019 Mar 14.

Division of Pulmonary and Critical Care Medicine, Warren Alpert Medical School at Brown University, Providence, RI, United States of America. Electronic address:

Purpose: Medical errors occur at high rates in intensive care units (ICUs) and have great consequences. The impact of errors on healthcare professionals is rarely discussed. We hypothesized that issues regarding blame and guilt following errors in the ICU exist and may be dependent on type of practitioner, level of experience, and error type. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.03.001DOI Listing

Response to Letter to the Editor (Mangioni et al).

J Crit Care 2019 Mar 20. Epub 2019 Mar 20.

Department of Critical Care Medicine, Queen's University, Kingston, Ontario, Canada; Kingston Health Sciences Center, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jcrc.2019.03.004DOI Listing

Transcriptome profiling and fast microbiology in sepsis diagnosis: A potential synergy we cannot neglect.

J Crit Care 2019 Mar 20. Epub 2019 Mar 20.

Department of Pathophysiology and Transplantation, School of Medicine and Surgery, University of Milan, Milan, Italy; Infectious Diseases Unit, Departement of Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.03.005DOI Listing

Prospective study: Diaphragmatic thickness as a predictor index for weaning from mechanical ventilation.

J Crit Care 2019 Mar 15;52:10-15. Epub 2019 Mar 15.

Faculty of Medicine, Tanta University, Department of Diagnostic Radiology, Tanta University Hospital, Tanta, Egypt.

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http://dx.doi.org/10.1016/j.jcrc.2019.03.006DOI Listing
March 2019
2 Reads

Systemic response of coated-platelet and peripheral blood inflammatory cell indices after aneurysmal subarachnoid hemorrhage and long-term clinical outcome.

J Crit Care 2019 Mar 14;52:1-9. Epub 2019 Mar 14.

Departments of Neurology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Purpose: Post-hemorrhage period after aneurysmal subarachnoid hemorrhage (aSAH) has several systemic manifestations including prothrombotic and pro-inflammatory states. Inter-relationship between these states using established/routine laboratory biomarkers and its long-term effect on clinical outcome is not well-defined.

Materials And Methods: Retrospective analysis of prospective cohort of 44 aSAH patients. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.03.003DOI Listing
March 2019
1 Read

Lung nitroxidative stress in mechanically-ventilated septic patients: A pilot study.

J Crit Care 2019 Feb 20;51:204-212. Epub 2019 Feb 20.

Center for Free Radical and Biomedical Research (CEINBIO), Facultad de Medicina, Universidad de la República, Montevideo, Uruguay; Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Electronic address:

Purpose: During sepsis and mechanical ventilation oxidative stress is generated by endothelial and inflammatory lung cells. Our main objective was to study pulmonary NO (nitric oxide) production and nitroxidative stress in mechanically-ventilated septic patients.

Methods: We study 69 mechanically ventilated patients, 36 with sepsis and 33 without sepsis within the first 48 h of ICU admission compared with 33 mechanically ventilated patients without sepsis (MV) plus eight operating room patients without lung disease served as control healthy group (ORCG). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183141
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http://dx.doi.org/10.1016/j.jcrc.2019.02.017DOI Listing
February 2019
3 Reads

Modification of sequential organ failure assessment score using acute kidney injury classification.

J Crit Care 2019 Feb 26;51:198-203. Epub 2019 Feb 26.

Department of Emergency and Critical Care Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. Electronic address:

Purpose: To assess the predictive validity of a modified Sequential Organ Failure Assessment (SOFA) score, of which the renal component was replaced with Kidney Disease Improving Global Outcomes (KDIGO) classification of Acute Kidney Injury (AKI).

Materials And Methods: Using a prospective cohort study on AKI in Japan, we replaced the renal component of SOFA score with AKI stages according to the KDIGO criteria except that initiation of renal replacement therapy was assigned four points. We assessed the predictive validity of KDIGO-based SOFA score for hospital and ICU mortality by comparing the areas under the receiver operating characteristic curve (AUC) derived from logistic regression models with that of the original SOFA score. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.026DOI Listing
February 2019
1 Read

Ability to predict team members' behaviors in ICU teams is associated with routine ABCDE implementation.

J Crit Care 2019 Mar 1;51:192-197. Epub 2019 Mar 1.

Department of Systems, Population, and Leadership, University of Michigan School of Nursing, Ann Arbor, MI, United States of America.

Purpose: Poor coordination may impede delivery of the Awakening, Breathing Coordination, Delirium monitoring/management and Early exercise/mobility (ABCDE) bundle. Developing a shared mental model (SMM), where all team members are on the same page, may support coordination.

Materials And Methods: We administered a survey at the 2016 MHA Keystone Center ICU workshop. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.028DOI Listing
March 2019
2 Reads

Sodium bicarbonate therapy for critically ill patients with metabolic acidosis: A scoping and a systematic review.

J Crit Care 2019 Feb 26;51:184-191. Epub 2019 Feb 26.

Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia; School of Medicine, The University of Melbourne, Parkville, Melbourne, VIC, Australia.

Purpose: We aimed to assess the biochemical and physiological effects, clinical efficacy, and safety, of intravenous NaHCO3 therapy in critically ill patients with acute metabolic acidosis.

Methods: We conducted a scoping review concerning the biochemical and physiological effects of NaHCO3 (PART A), and a systematic review regarding clinical efficacy (PART B). We searched MEDLINE in Part A and MEDLINE, EMBASE, Cochrane, the National Institute of Health Clinical Trials Register, and the WHOICTRP for randomised controlled trials in Part B. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183152
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http://dx.doi.org/10.1016/j.jcrc.2019.02.027DOI Listing
February 2019
5 Reads

Association between strained ICU capacity and healthcare costs in Canada: A population-based cohort study.

J Crit Care 2019 Feb 26;51:175-183. Epub 2019 Feb 26.

School of Public Health, University of Alberta, Edmonton, Alberta, Canada; Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; Critical Care Strategic Clinical Network, Alberta Health Services, Edmonton, Alberta, Canada. Electronic address:

Background: Intensive care is resource intensive, with costs representing a substantial quantity of total hospitalization costs. Strained ICU capacity compromises care quality and adversely impacts outcomes; however, the association between strain and healthcare costs has not been explored.

Materials And Methods: Population-based cohort study performed in 17 adult ICUs in Alberta, Canada. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.025DOI Listing
February 2019
1 Read

Usefulness of a quantitative analysis of the cerebrospinal fluid volume proportion in brain computed tomography for predicting neurological prognosis in cardiac arrest survivors who undergo target temperature management.

J Crit Care 2019 Feb 20;51:170-174. Epub 2019 Feb 20.

Clinical Trial Center, Chungnam National University Hospital, 282, Munhwa-ro, Jung-gu, Daejeon, Republic of Korea.

Purpose: Brain swelling post-cardiac arrest may affect cerebrospinal fluid volume. We aimed to investigate the prognostic performance of the proportion of cerebrospinal fluid volume (pCSFV) using brain computed tomography (CT) in cardiac arrest survivors.

Materials And Methods: This retrospective multicentre study included adult comatose cardiac arrest survivors who underwent brain CT scan prior to target temperature management (TTM) from 2015 to 2016. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.024DOI Listing
February 2019
1 Read

Acute respiratory distress syndrome in leptospirosis.

J Crit Care 2019 Feb 18;51:165-169. Epub 2019 Feb 18.

Intensive Care Unit, Félix Guyon Hospital, University Teaching Hospital of La Réunion, CS11021, 97400 Saint Denis, Reunion Island, France.

Purpose: Acute Respiratory Distress Syndrome is a major complication of leptospirosis, leading to the majority of fatalities.

Methods: Retrospective, descriptive and single-center cohort study. The primary outcome was the Standardized Mortality Ratio (SMR) for ARDS in leptospirosis based on the quartiles of the SAPS2 score in the reference population of 1683 patients hospitalized for ARDS. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.018DOI Listing
February 2019
2 Reads

Response to comments.

J Crit Care 2019 Feb 12. Epub 2019 Feb 12.

Hospital Nossa Senhora da Conceição, Avenida Francisco Trein, 596, Porto Alegre - RS, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.02.010DOI Listing
February 2019

A practical approach to critical care ultrasound.

J Crit Care 2019 Feb 8;51:156-164. Epub 2019 Feb 8.

Department of Intensive Care, Radboud University Medical Center, PO Box 9101, 6500, HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jcrc.2019.01.002DOI Listing
February 2019

Importance of diastolic pressure in septic shock: Con - Response.

Authors:
Sheldon Magder

J Crit Care 2019 Feb 22. Epub 2019 Feb 22.

Department of Critical Care, McGill University Health Centre, 1001 Decarie Blvd, Montreal, Quebec H4A 3J1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.02.021DOI Listing
February 2019
1 Read

The perils of medico-legal advocacy in ICU conflicts at the end of life: A qualitative study of what happens when advocacy and best interests collide.

J Crit Care 2019 Feb 10;51:149-155. Epub 2019 Feb 10.

Head Division of Palliative Care, Department of Medicine, University of Ottawa, Canada.

An unexplored aspect of conflicts and conflict resolution in the ICU at EOL is the role of advocacy in both medicine and law.

Goal: Qualitative study to explore perspectives of SDM/patient lawyers on issues of advocacy at EOL to better understand conflicts and resolution processes.

Methods: Purposive sampling with criterion and snowball techniques were used to recruit 11 experienced lawyers for semi-structured interviews. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183072
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http://dx.doi.org/10.1016/j.jcrc.2019.02.013DOI Listing
February 2019
5 Reads

Admission characteristics predictive of in-hospital death from hospital-acquired sepsis: A comparison to community-acquired sepsis.

J Crit Care 2019 Feb 19;51:145-148. Epub 2019 Feb 19.

University of Florida College of Medicine-Jacksonville, Department of Emergency Medicine, Jacksonville, FL, United States of America. Electronic address:

Purpose: Healthcare associated (HA) sepsis is associated with increased resource utilization and mortality compared with community acquired (CA) sepsis. The purpose of this study was to identify independent predictors of in-hospital mortality from HA-sepsis.

Materials And Methods: Retrospective study of adult patients admitted with HA or CA-sepsis. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.023DOI Listing
February 2019
1 Read

Serum albumin as a risk factor for death in patients with prolonged sepsis: An observational study.

J Crit Care 2019 Feb 4;51:139-144. Epub 2019 Feb 4.

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address:

Purpose: The aim of this study was to evaluate an association between nutritional biomarkers and prognosis in septic patients.

Methods: We retrospectively searched the association between nutritional biomarkers including serum albumin (Alb), total protein (TP), total cholesterol (T-chol), and cholinesterase (ChE), and prognosis for septic patients treated in the ICU for >7 days. We used time-dependent Cox proportional hazard regression analysis to resolve the difference of the statistical weight of each day's data for all 14 consecutive days among individual sepsis patients. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.004DOI Listing
February 2019

Hydroxyethyl starch and fluid resuscitation: Patient-oriented outcome is the "right way". Authors' reply.

J Crit Care 2019 Feb 18. Epub 2019 Feb 18.

Meridian HealthComms, Plumley Moor Road, Plumley, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.02.022DOI Listing
February 2019
1 Read

The evolution of diaphragm activity and function determined by ultrasound during spontaneous breathing trials.

J Crit Care 2019 Feb 18;51:133-138. Epub 2019 Feb 18.

Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Purpose: Rapid shallow breathing index (RSBI) is a commonly used index for predicting the outcome of spontaneous breathing trial (SBT). Ultrasound is a non-invasive technique for assessing diaphragm activity and function. This study aimed to investigate changes in diaphragm activity during SBT, and to compare diaphragm function between patients with and without SBT success. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.016DOI Listing
February 2019
2 Reads

A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit.

J Crit Care 2019 Feb 13;51:122-132. Epub 2019 Feb 13.

Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. Electronic address:

Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world.

Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult (>16 years) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.015DOI Listing
February 2019

Persistently high circulating tissue inhibitor of matrix metalloproteinase-1 levels in non-survivor brain trauma injury patients.

J Crit Care 2019 Feb 19;51:117-121. Epub 2019 Feb 19.

Atherosclerosis Research Laboratory, CIMA-University of Navarra, Avda Pío XII n°55, Pamplona 31008, Spain. Electronic address:

Purpose: Previously, higher circulating levels of matrix metalloproteinase (MMP)-9 and tissue inhibitor matrix metalloproteinases (TIMP)-1 were reported in the first hours after TBI in blood samples from patients with poor prognosis. Thus, the objectives of this study were to determine whether MMP-9 and TIMP-1 levels during the first week of a severe TBI could be used as biomarker predictive of mortality.

Methods: We included patients with severe TBI (defined as Glasgow Coma Scale lower than 9), and with Injury Severity Score in non-cranial aspects lower than 9. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.014DOI Listing
February 2019

Severe acute respiratory distress syndrome (ARDS) induced by human adenovirus B21: Report on 2 cases and literature review.

J Crit Care 2019 Feb 13;51:99-104. Epub 2019 Feb 13.

Institute for Infectious Diseases, University of Bern, Friedbuehlstrasse 51, 3010 Bern, Switzerland; Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland. Electronic address:

Severe pneumonia and ARDS caused by human adenovirus B21 infections (HAdV-B21) is a rare, but a devastating disease with rapid progression to multiorgan failure and death. However, only a few cases were reported so far. Infections appear associated with increased disease severity and higher mortality in infected critically ill patients. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.019DOI Listing
February 2019

Acute kidney injury following contrast media administration in the septic patient: A retrospective propensity-matched analysis.

J Crit Care 2019 Feb 4;51:111-116. Epub 2019 Feb 4.

Department of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States; Center for Disease Dynamics, Economics & Policy, Washington, DC, United States.

Purpose: To determine the risk for acute kidney injury (AKI) attributable to intravenous contrast media (CM) administration in septic patients.

Materials And Methods: This was a single-center retrospective propensity matched cohort analysis performed in the emergency department (ED) of an academic medical center. All visits for patients ≥18 years who met sepsis diagnostic criteria and had serum creatinine (SCr) measured both on arrival to the ED and again 48 to 72 h later were included. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.003DOI Listing
February 2019

The effect of the first-year residents orientation period on intensive care and hospital mortality, in a medical intensive care unit, within a developing country.

J Crit Care 2019 Feb 15;51:105-110. Epub 2019 Feb 15.

Division of Intensive Care Medicine, Hacettepe University School of Medicine, Ankara, Turkey.

Purpose: To determine whether the adaptation of junior residents, during their first week rotation period within the ICU, has any effect on ICU and hospital mortality rates, in a developing country.

Materials And Methods: Patients who were admitted to the ICU were included, with 1207 out of 1547 of the admitted patients being eligible. The effect of age, gender, co-morbidities, the cause of the ICU admission, the presence of hospital-acquired infections, residents rotation week, admission time (weekday vs. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.020DOI Listing
February 2019
1 Read

Hydroxyethyl starch and fluid resuscitation: Patient-oriented outcome is the "right way".

J Crit Care 2019 Feb 10. Epub 2019 Feb 10.

Department of Anaesthesia and Intensive Care, University La Sapienza, Rome, Italy.

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http://dx.doi.org/10.1016/j.jcrc.2019.02.012DOI Listing
February 2019

In-hospital resuscitation team composition: Are three heads really better than six?

J Crit Care 2019 Feb 7. Epub 2019 Feb 7.

Research Center for Emergency Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark; Department of Internal Medicine, Randers Regional Hospital, Skovlyvej 15, 8930 Randers, NØ, Denmark; Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

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http://dx.doi.org/10.1016/j.jcrc.2019.01.017DOI Listing
February 2019

Response to letter: Comparing high flow nasal therapy and standard oxygen during breaks off non-invasive ventilation.

J Crit Care 2019 Jan 31. Epub 2019 Jan 31.

Respiratory Department, St James's University Hospital, Leeds Teaching Hospital NHS Trust, Leeds, UK; Leeds Institute for Medical Research, School of Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1016/j.jcrc.2019.01.015DOI Listing
January 2019

Controversial supremacy: Are colloids better than crystalloids? Authors' reply.

J Crit Care 2019 Feb 10. Epub 2019 Feb 10.

Meridian HealthComms, Plumley Moor Road, Plumley, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.02.011DOI Listing
February 2019

Adherence to fluid resuscitation guidelines and outcomes in patients with septic shock: Reassessing the "one-size-fits-all" approach.

J Crit Care 2019 Feb 5;51:94-98. Epub 2019 Feb 5.

Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Objective: The Surviving Sepsis Campaign and Centers for Medicare and Medicaid Services (CMS) Severe Sepsis and Septic Shock Management Bundle (SEP-1) recommend rapid crystalloid infusion (≥30 mL/kg) for patients with sepsis-induced hypoperfusion or septic shock. We aimed to assess compliance with this recommendation, factors associated with non-compliance, and how compliance relates to mortality.

Design: Retrospective, observational study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183157
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http://dx.doi.org/10.1016/j.jcrc.2019.02.006DOI Listing
February 2019
12 Reads

Worldwide variation in Pseudomonas associated ventilator associated pneumonia. A meta-regression.

Authors:
James C Hurley

J Crit Care 2019 Feb 6;51:88-93. Epub 2019 Feb 6.

Department of Rural Health, Melbourne Medical School, University of Melbourne, Internal Medicine Service, Ballarat Health Services, Victoria, Australia. Electronic address:

Purpose: The objective here is to define the extent and possible reasons for geographic variation in Pseudomonas aeruginosa associated with Ventilator Associated Pneumonia (VAP).

Methods: A random effects meta-regression model of Pseudomonas associated VAP incidence within the published literature was undertaken incorporating group level factors such trauma admission, year of publication and use of bronchoscopic sampling towards VAP diagnosis.

Results: Pseudomonas associated VAP incidence was reported in 162 studies from seven worldwide regions published over 30 years. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.001DOI Listing
February 2019
7 Reads

ICU readmission of patients with cancer: Incidence, risk factors and mortality.

J Crit Care 2019 Feb 7;51:84-87. Epub 2019 Feb 7.

Department of Medicine, Section of Pulmonary and Critical Care, King Hussein Cancer Center, Jordan. Electronic address:

Purpose: Few studies evaluated ICU readmission in cancer patients. This study aimed to describe the incidence and risk factors for ICU readmission in cancer patients and the association with mortality.

Materials And Methods: A retrospective cohort study at a comprehensive cancer center, which included cancer patients who were discharged after their initial ICU admission over a 5-year period. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.008DOI Listing
February 2019
2 Reads
2.191 Impact Factor

A decision-aid tool for ICU admission triage is associated with a reduction in potentially inappropriate intensive care unit admissions.

J Crit Care 2019 Feb 4;51:77-83. Epub 2019 Feb 4.

Medical Sciences PhD program, Faculdade de Medicina FMUSP, Universidade de São Paulo, Sao Paulo, Brazil; Teaching and Research on Palliative Care Program, Hospital Sirio-Libanes, Sao Paulo, Brazil.

Purpose: Intensive care unit (ICU) admission triage occurs frequently and often involves highly subjective decisions that may lead to potentially inappropriate ICU admissions. In this study, we evaluated the effect of implementing a decision-aid tool for ICU triage on ICU admission decisions.

Methods: This was a prospective, before-after study. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.002DOI Listing
February 2019

The effect of direct hemoperfusion with polymyxin B immobilized cartridge on meropenem in critically ill patients requiring renal support.

J Crit Care 2019 Feb 5;51:71-76. Epub 2019 Feb 5.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:

Purpose: To evaluate the effect of direct hemoperfusion with polymyxin B immobilized cartridge (DHP-PMX) on meropenem pharmacokinetics in critically ill patients with sepsis requiring continuous venovenous hemofiltration (CVVH).

Material And Methods: After intravenous infusion of 1 g meropenem over 3 h repeated every 8 h for at least 3 doses, 2 serial blood and ultrafiltration fluid samples were collected: one over a dose interval of meropenem with DHP-PMX therapy; and the other on the following day over a dose interval of meropenem with no DHP-PMX therapy. Meropenem concentrations were measured by high performance liquid chromatography. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.007DOI Listing
February 2019
1 Read

Epidemiology and clinical outcomes of invasive mould infections in Indian intensive care units (FISF study).

J Crit Care 2019 Feb 5;51:64-70. Epub 2019 Feb 5.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background And Aim: Due to limited data on invasive mould infections (IMIs) in the intensive care units (ICUs) of developing countries, we ascertain epidemiology and management of IMIs at 11 ICUs across India.

Methods: Consecutive patients with proven or probable/putative IMIs were enrolled during the study period. Subjects were categorized into classical (neutropenia, malignancy, transplant recipients on immunosuppression) and non-classical (chronic obstructive pulmonary disease, diabetes, liver disease and glucocorticoids) risk groups. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.005DOI Listing
February 2019
9 Reads

Depression and anxiety in relatives of out-of-hospital cardiac arrest patients: Results of a prospective observational study.

J Crit Care 2019 Jan 28;51:57-63. Epub 2019 Jan 28.

Department of Medical Communication, University Hospital Basel, Klingelbergstrasse 23, CH-4031, Switzerland; Medical Intensive Care Unit, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland; Department of Psychosomatic Medicine, University Hospital Basel and University of Basel, Hebelstrasse 2, CH-4031 Basel, Switzerland. Electronic address:

Purpose: Relatives of patients admitted to the intensive care unit (ICU) with out-of-hospital cardiac arrest (OHCA) may suffer from adverse psychological outcomes. We assessed prevalence and risk factors for depression and anxiety in such relatives 90 days after ICU admission.

Materials And Methods: This study included consecutive relatives of OHCA patients admitted to the ICU of University Hospital in Basel, Switzerland. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.026DOI Listing
January 2019
1 Read
2.191 Impact Factor

Physical impairment and perceived general health preceding critical illness is predictive of survival.

J Crit Care 2019 Jan 29;51:51-56. Epub 2019 Jan 29.

Gelre Hospitals Apeldoorn, Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands; Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Purpose: We hypothesized that item response based assessment of physical reserve preceding ICU admission is a predictor of survival.

Methods: We evaluated physical functioning using the Academic Medical Center Linear Disability Score (ALDS) and quality of life using the first question (SF-1) and the physical component score (PCS-12) from the Short-form 12 (SF-12) before admission by patients or by close proxies within 72 h after ICU admission during 1 year.

Results: We developed four logistic regression models to predict 1 year mortality using the predictors age, gender, ALDS, SF-1, PCS-12. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.027DOI Listing
January 2019

Measuring antibiotics in exhaled air in critically ill, non-ventilated patients: A feasibility and proof of concept study.

J Crit Care 2019 Jan 28;51:46-50. Epub 2019 Jan 28.

Ghent University Hospital, Dept. of Critical Care Medicine, C. Heymanslaan 10, 9000 Ghent, Belgium. Electronic address:

Purpose: Measurement of antibiotic concentrations is increasingly used to optimize antibiotic therapy. Plasma samples are typically used for this, but other matrices such as exhaled air could be an alternative.

Materials And Methods: We studied 11 spontaneously breathing intensive care unit patients receiving either piperacillin/tazobactam or meropenem. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.025DOI Listing
January 2019