3,377 results match your criteria Journal of Critical Care[Journal]


Adherence to fluid resuscitation guidelines and outcomes in patients with septic shock: Reassessing the "one-size-fits-all" approach.

J Crit Care 2019 Feb 5;51:94-98. Epub 2019 Feb 5.

Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Objective: The Surviving Sepsis Campaign and Centers for Medicare and Medicaid Services (CMS) Severe Sepsis and Septic Shock Management Bundle (SEP-1) recommend rapid crystalloid infusion (≥30 mL/kg) for patients with sepsis-induced hypoperfusion or septic shock. We aimed to assess compliance with this recommendation, factors associated with non-compliance, and how compliance relates to mortality.

Design: Retrospective, observational study. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.006DOI Listing
February 2019

Worldwide variation in Pseudomonas associated ventilator associated pneumonia. A meta-regression.

Authors:
James C Hurley

J Crit Care 2019 Feb 6;51:88-93. Epub 2019 Feb 6.

Department of Rural Health, Melbourne Medical School, University of Melbourne, Internal Medicine Service, Ballarat Health Services, Victoria, Australia. Electronic address:

Purpose: The objective here is to define the extent and possible reasons for geographic variation in Pseudomonas aeruginosa associated with Ventilator Associated Pneumonia (VAP).

Methods: A random effects meta-regression model of Pseudomonas associated VAP incidence within the published literature was undertaken incorporating group level factors such trauma admission, year of publication and use of bronchoscopic sampling towards VAP diagnosis.

Results: Pseudomonas associated VAP incidence was reported in 162 studies from seven worldwide regions published over 30 years. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.001DOI Listing
February 2019
2 Reads

ICU readmission of patients with cancer: Incidence, risk factors and mortality.

J Crit Care 2019 Feb 7;51:84-87. Epub 2019 Feb 7.

Department of Medicine, Section of Pulmonary and Critical Care, King Hussein Cancer Center, Jordan. Electronic address:

Purpose: Few studies evaluated ICU readmission in cancer patients. This study aimed to describe the incidence and risk factors for ICU readmission in cancer patients and the association with mortality.

Materials And Methods: A retrospective cohort study at a comprehensive cancer center, which included cancer patients who were discharged after their initial ICU admission over a 5-year period. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.008DOI Listing
February 2019
2 Reads
2.191 Impact Factor

A decision-aid tool for ICU admission triage is associated with a reduction in potentially inappropriate intensive care unit admissions.

J Crit Care 2019 Feb 4;51:77-83. Epub 2019 Feb 4.

Medical Sciences PhD program, Faculdade de Medicina FMUSP, Universidade de São Paulo, Sao Paulo, Brazil; Teaching and Research on Palliative Care Program, Hospital Sirio-Libanes, Sao Paulo, Brazil.

Purpose: Intensive care unit (ICU) admission triage occurs frequently and often involves highly subjective decisions that may lead to potentially inappropriate ICU admissions. In this study, we evaluated the effect of implementing a decision-aid tool for ICU triage on ICU admission decisions.

Methods: This was a prospective, before-after study. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.002DOI Listing
February 2019

The effect of direct hemoperfusion with polymyxin B immobilized cartridge on meropenem in critically ill patients requiring renal support.

J Crit Care 2019 Feb 5;51:71-76. Epub 2019 Feb 5.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:

Purpose: To evaluate the effect of direct hemoperfusion with polymyxin B immobilized cartridge (DHP-PMX) on meropenem pharmacokinetics in critically ill patients with sepsis requiring continuous venovenous hemofiltration (CVVH).

Material And Methods: After intravenous infusion of 1 g meropenem over 3 h repeated every 8 h for at least 3 doses, 2 serial blood and ultrafiltration fluid samples were collected: one over a dose interval of meropenem with DHP-PMX therapy; and the other on the following day over a dose interval of meropenem with no DHP-PMX therapy. Meropenem concentrations were measured by high performance liquid chromatography. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.007DOI Listing
February 2019
1 Read

Epidemiology and clinical outcomes of invasive mould infections in Indian intensive care units (FISF study).

J Crit Care 2019 Feb 5;51:64-70. Epub 2019 Feb 5.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background And Aim: Due to limited data on invasive mould infections (IMIs) in the intensive care units (ICUs) of developing countries, we ascertain epidemiology and management of IMIs at 11 ICUs across India.

Methods: Consecutive patients with proven or probable/putative IMIs were enrolled during the study period. Subjects were categorized into classical (neutropenia, malignancy, transplant recipients on immunosuppression) and non-classical (chronic obstructive pulmonary disease, diabetes, liver disease and glucocorticoids) risk groups. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.005DOI Listing
February 2019
1 Read

Depression and anxiety in relatives of out-of-hospital cardiac arrest patients: Results of a prospective observational study.

J Crit Care 2019 Jan 28;51:57-63. Epub 2019 Jan 28.

Department of Medical Communication, University Hospital Basel, Klingelbergstrasse 23, CH-4031, Switzerland; Medical Intensive Care Unit, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland; Department of Psychosomatic Medicine, University Hospital Basel and University of Basel, Hebelstrasse 2, CH-4031 Basel, Switzerland. Electronic address:

Purpose: Relatives of patients admitted to the intensive care unit (ICU) with out-of-hospital cardiac arrest (OHCA) may suffer from adverse psychological outcomes. We assessed prevalence and risk factors for depression and anxiety in such relatives 90 days after ICU admission.

Materials And Methods: This study included consecutive relatives of OHCA patients admitted to the ICU of University Hospital in Basel, Switzerland. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.026DOI Listing
January 2019
1 Read

Physical impairment and perceived general health preceding critical illness is predictive of survival.

J Crit Care 2019 Jan 29;51:51-56. Epub 2019 Jan 29.

Gelre Hospitals Apeldoorn, Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands; Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Purpose: We hypothesized that item response based assessment of physical reserve preceding ICU admission is a predictor of survival.

Methods: We evaluated physical functioning using the Academic Medical Center Linear Disability Score (ALDS) and quality of life using the first question (SF-1) and the physical component score (PCS-12) from the Short-form 12 (SF-12) before admission by patients or by close proxies within 72 h after ICU admission during 1 year.

Results: We developed four logistic regression models to predict 1 year mortality using the predictors age, gender, ALDS, SF-1, PCS-12. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.027DOI Listing
January 2019

Measuring antibiotics in exhaled air in critically ill, non-ventilated patients: A feasibility and proof of concept study.

J Crit Care 2019 Jan 28;51:46-50. Epub 2019 Jan 28.

Ghent University Hospital, Dept. of Critical Care Medicine, C. Heymanslaan 10, 9000 Ghent, Belgium. Electronic address:

Purpose: Measurement of antibiotic concentrations is increasingly used to optimize antibiotic therapy. Plasma samples are typically used for this, but other matrices such as exhaled air could be an alternative.

Materials And Methods: We studied 11 spontaneously breathing intensive care unit patients receiving either piperacillin/tazobactam or meropenem. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.025DOI Listing
January 2019

Atrial natriuretic peptide for treatment of acute kidney injury (AKI) - Initiate an optimal dose early.

J Crit Care 2018 Dec 26. Epub 2018 Dec 26.

Department of Critical Care Medicine, Faculty of Medicine and Dentistry, School of Public Health, University of Alberta, 2-124E Clinical Sciences Building, 8440-112 ST NW, Edmonton T6G2B7, Canada.

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http://dx.doi.org/10.1016/j.jcrc.2018.12.013DOI Listing
December 2018
1 Read

Selecting and evaluating decision-making strategies in the intensive care unit: A systematic review.

J Crit Care 2019 Jan 30;51:39-45. Epub 2019 Jan 30.

Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, The Netherlands. Electronic address:

Purpose: Many patients in the Intensive Care Unit (ICU) die after a decision to withhold or withdraw treatment. To ensure that for each patient the appropriate decision is taken, a careful decision-making process is required. This review identifies strategies that can be used to optimize the decision-making process for continuing versus limiting life sustaining treatment of ICU patients. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.029DOI Listing
January 2019

The nitric oxide pathway antagonists in septic shock: Meta-analysis of controlled clinical trials.

J Crit Care 2019 Jan 22;51:34-38. Epub 2019 Jan 22.

University of Texas Medical Branch, Anesthesiology Department, Galveston 77555, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.01.013DOI Listing
January 2019
1 Read

Is central venous pressure really associated with acute kidney injury and mortality after cardiovascular surgery with cardiopulmonary bypass?

J Crit Care 2019 Jan 30. Epub 2019 Jan 30.

Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

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http://dx.doi.org/10.1016/j.jcrc.2019.01.024DOI Listing
January 2019
1 Read

Automated and cost-efficient early detection of hemolysis in patients with extracorporeal life support: Use of the hemolysis-index of routine clinical chemistry platforms.

J Crit Care 2019 Jan 30;51:29-33. Epub 2019 Jan 30.

Department of Clinical Chemistry, St. Antonius Hospital, Nieuwegein, Utrecht, The Netherlands.

Purpose: Patients with extracorporeal life support (ECLS) are at risk for hemolysis-related complications. Therefore, monitoring of free hemoglobin (fHb) levels is indicated. Conventional methods for fHb are laborious and not always available. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.028DOI Listing
January 2019

Successful treatment of abdominal compartment syndrome with chemotherapy in a patient with a newly diagnosed Burkitt lymphoma.

J Crit Care 2019 Jan 22;51:26-28. Epub 2019 Jan 22.

Department of Anesthesiology and Operative Intensive Care Medicine, Medical Center Cologne Merheim, University of Witten/Herdecke, Germany. Electronic address:

Mortality of patients treated on the intensive care unit suffering from cancer is high, especially when admitted with an unknown malignancy. Still, anti-tumor therapy in critically ill patients requiring mechanical ventilation is a clinical challenge. Over the last years, successful chemotherapy has been reported, even in critically ill patients with infections and organ failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183165
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http://dx.doi.org/10.1016/j.jcrc.2019.01.021DOI Listing
January 2019
3 Reads

Letter in reply.

J Crit Care 2019 Jan 22. Epub 2019 Jan 22.

Medical Intensive Care Unit, University Hospital Basel, University of Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jcrc.2019.01.018DOI Listing
January 2019
1 Read

Inhaled nitric oxide prevents systemic and pulmonary vasoconstriction due to hemoglobin-based oxygen carrier infusion: A case report.

J Crit Care 2019 Jan 29. Epub 2019 Jan 29.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:

Hemoglobin-based oxygen carriers (HBOCs) are used in extreme circumstances to increase hemoglobin concentration and improve oxygen delivery when allogenic red blood cell transfusions are contraindicated or not immediately available. However, HBOC-induced severe pulmonary and systemic vasoconstriction due to peripheral nitric oxide (NO) scavenging has stalled its implementation in clinical practice. We present a case of an 87 year-old patient with acute life-threatening anemia who received HBOC while breathing NO gas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183020
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http://dx.doi.org/10.1016/j.jcrc.2018.04.008DOI Listing
January 2019
4 Reads

Inhaled nitric oxide for safer use of hemoglobin-based oxygen carrier infusion (HBOC): A new indication?

Authors:
Didier Payen

J Crit Care 2019 Jan 22. Epub 2019 Jan 22.

UMR INSERM 1160, Université Paris 7 Denis-Diderot, Paris Cité Sorbonne, France. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.01.019DOI Listing
January 2019

Letter to the Editor: Comparing high flow nasal therapy and standard oxygen during breaks off non-invasive ventilation.

J Crit Care 2019 Jan 22. Epub 2019 Jan 22.

Department of Intensive Care Unit, Hospital General University Morales Meseguer, Murcia, Spain.

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http://dx.doi.org/10.1016/j.jcrc.2019.01.016DOI Listing
January 2019

Interactive video games for rehabilitation in the intensive care unit: A pilot study.

J Crit Care 2019 Jan 22;51:24-25. Epub 2019 Jan 22.

Department of intensive care, Catharina Hospital, Michelangelolaan 2, 5623 EJ Eindhoven, the Netherlands.

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http://dx.doi.org/10.1016/j.jcrc.2019.01.022DOI Listing
January 2019

The relationship between self-report and performance-based measures of physical function following an ICU stay.

J Crit Care 2019 Jan 21;51:19-23. Epub 2019 Jan 21.

Department of Internal Medicine, University of Kentucky, Lexington, KY, USA.

Purpose: To examine relationships between self-report and performance-based measures of physical function in ICU patients randomized to standardized rehabilitation therapy (SRT) or usual care (UC).

Methods: Physical function was assessed in 257 ICU patients using self-report (physical functioning scale of the SF-36 (SF-36 PFS)) and the functional performance inventory-short form (FPI-SF) as well as performance-based measures (Short Physical Performance Battery (SPPB)) and muscular strength (MS). Assessments were at hospital discharge, 2, 4, and 6 months. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.020DOI Listing
January 2019

Usefulness of qSOFA and SIRS scores for detection of incipient sepsis in general ward patients: A prospective cohort study.

J Crit Care 2019 Jan 18;51:13-18. Epub 2019 Jan 18.

Medical Intensive Care Unit, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing 100730, China. Electronic address:

Purpose: To prospectively assess the diagnostic value of quick Sequential Organ Failure Assessment (qSOFA) and systemic inflammatory response syndrome (SIRS) scores for sepsis in ward patients with infections.

Materials And Methods: Consecutive patients admitted with infection or developing infection during hospital stay were included. All variables for calculating qSOFA, SIRS, and SOFA scores were collected, and the maximum scores were determined until hospital discharge, death, or day 28, whichever occurred earlier. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.012DOI Listing
January 2019
1 Read

Variability in intensive care unit length of stay after liver transplant: Determinants and potential opportunities for improvement.

J Crit Care 2019 Apr 9;50:296-302. Epub 2019 Jan 9.

Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

Purpose: Recovery after liver transplant (LT) requires extensive resources, including prolonged intensive care unit stays. The objective of this study was to use an assessment tool to determine if LT recipients remain in ICU beyond designated indications.

Methods: Records from 100 consecutive LTs performed in a single institution were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.003DOI Listing

Implementation of a structured communication tool improves family satisfaction and expectations in the intensive care unit.

J Crit Care 2019 Jan 14;51:6-12. Epub 2019 Jan 14.

Minerva Center for the Interdisciplinary Study of End of Life, Tel-Aviv University, Israel.

Background: Intensive care unit (ICU) physicians should provide relatives of critically ill patients with appropriate and clear information, regarding prognosis, treatment options and expectations.

Objectives: To assess whether a structured communication tool improves satisfaction with care and engenders realistic expectations among relatives of critically ill patients.

Study Design: A controlled, pre-post intervention design was implemented in the General and Medical ICUs in the Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.011DOI Listing
January 2019

Interventions for the management and prevention of sarcopenia in the critically ill: A systematic review.

J Crit Care 2019 Apr 14;50:287-295. Epub 2019 Jan 14.

University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Institute of Applied Health Research, University of Birmingham, Birmingham, UK.. Electronic address:

Purpose: In the critically ill, sarcopenia is associated with a variety of adverse outcomes however there is no consensus regarding its management. This study aimed to systematically review the evidence for interventions for the management and prevention of sarcopenia in critically ill patients.

Materials And Methods: Bibliographic databases were searched according to pre-specified criteria (PROSPERO-CRD42018086271). Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.008DOI Listing

Impact of chronic right ventricular pressure overload in short-term outcomes of acute pulmonary embolism: A retrospective analysis.

J Crit Care 2019 Jan 11;51:1-5. Epub 2019 Jan 11.

Department of Emergency Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States. Electronic address:

Purpose: Evaluate the association between chronic right ventricle (RV) dysfunction by transthoracic echocardiogram (TTE) and outcomes in patients with acute pulmonary embolism (PE).

Methods: This was a retrospective analysis of TTE findings in acute PEs. TTEs were used to classify the presence of chronic right ventricular pressure overload (RPVO), defined as RV hypertrophy or RV systolic pressure (RVSP) >50 mmHg, acute RVPO, defined as RV dysfunction not meeting the chronic RVPO definition, or no RV dysfunction. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.007DOI Listing
January 2019
1 Read

Constipation, diarrhea, and prophylactic laxative bowel regimens in the critically ill: A systematic review and meta-analysis.

J Crit Care 2019 Jan 10. Epub 2019 Jan 10.

The University of Melbourne, Melbourne Medical School, Department of Medicine and Radiology, Royal Melbourne Hospital, Parkville, VIC 3050, Australia; Intensive Care Unit, The Royal Melbourne Hospital, Parkville, Victoria, Australia. Electronic address:

Introduction: Prophylactic laxative bowel regimens may prevent constipation in enterally-fed critically ill patients. However, their use may also increase diarrhea. We performed a systematic review to: 1. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.004DOI Listing
January 2019
1 Read

Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials.

J Crit Care 2019 Apr 12;50:280-286. Epub 2019 Jan 12.

Pulmonary and Critical Care Departments, Hurley Medical Center, Michigan State University, Flint, MI, United States.

Purpose: Delirium commonly presents as a complication in critically ill patients. Our aim is to perform a meta-analysis investigating the role of haloperidol versus placebo in management (treatment and prophylaxis), of delirium in intensive care unit (ICU).

Materials And Methods: Our study is a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing haloperidol versus placebo for treatment and/or prophylaxis of ICU-related delirium. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.009DOI Listing
April 2019
2 Reads

Prevalence of acute kidney injury after liver transplantation in children: Comparison of the pRIFLE, AKIN, and KDIGO criteria using corrected serum creatinine.

J Crit Care 2019 Apr 14;50:275-279. Epub 2019 Jan 14.

Department of Pediatric Gastroenterology, Schneider Children's Medical Center of Israel, Petach Tikva, Affiliated With Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Purpose: To compare the application of three standardized definitions of acute kidney injury (AKI), using corrected serum creatinine values, in children immediately after liver transplantation.

Methods: Retrospective search of a tertiary pediatric hospital database yielded 77 patients (age < 18 years) who underwent liver transplantation in 2007-2017. Serum creatinine levels during the 24 h before and after surgery were corrected to daily fluid balance, and the prevalence of AKI was calculated using the Pediatric RIFLE (pRIFLE), AKI Network (AKIN), and Kidney Disease Improving Global Outcomes (KDIGO) criteria. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.010DOI Listing
April 2019
2 Reads

Association of septic shock definitions and standardized mortality ratio in a contemporary cohort of critically ill patients.

J Crit Care 2019 Apr 11;50:269-274. Epub 2019 Jan 11.

Multidisciplinary Epidemiology and Translational Research in Intensive Care- METRIC, Mayo Clinic, Rochester, MN, United States; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, United States.

Purpose: The newly proposed septic shock definition has provoked a substantial controversy in the emergency and critical care communities. We aim to compare new (SEPSIS-III) versus old (SEPSIS-II) definitions for septic shock in a contemporary cohort of critically ill patients.

Material And Methods: Retrospective cohort of consecutive patients, age ≥ 18 years admitted to intensive care units at the Mayo Clinic between January 2009 and October 2015. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.005DOI Listing
April 2019
2 Reads

Prescription patterns for routine EEG ordering in patients with intracranial hemorrhage admitted to a neurointensive care unit.

J Crit Care 2019 Apr 11;50:262-268. Epub 2019 Jan 11.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA; Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address:

Purpose: To examine clinical factors, including established electroencephalography (EEG) consensus recommendations, that may influence EEG-prescription in critically-ill intracerebral hemorrhage (ICH) patients in the neurointensive care unit.

Methods: Retrospective analysis of 330 ICH patients admitted to a neurointensive care unit at an academic medical center between 01/2013-12/2015. We compared EEG prescription patterns with current EEG consensus recommendations, and employed univariate and multivariable logistic regression modeling to determine clinical variables associated with EEG ordering. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.01.006DOI Listing
April 2019
2 Reads

Comparison of outcomes and costs between adult diabetic ketoacidosis patients admitted to the ICU and step-down unit.

J Crit Care 2019 Apr 25;50:257-261. Epub 2018 Dec 25.

Division of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; Division of Palliative Care, Department of Medicine, University of Ottawa, Ottawa, ON, Canada; Institut du Savoir Montfort, Ottawa, ON, Canada.

Purpose: There is wide variation in the utilization of Intensive Care Unit (ICU) beds for treatment and monitoring of adult patients with Diabetic Ketoacidosis (DKA). We sought to compare the outcomes and hospital costs of adult DKA patients admitted to ICUs as compared to those admitted to step-down units.

Materials And Methods: We included consecutive adult patients from two hospitals with a diagnosis of DKA. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.014DOI Listing
April 2019
1 Read

High flow nasal therapy in immunocompromised patients with acute respiratory failure: A systematic review and meta-analysis.

J Crit Care 2019 Apr 29;50:250-256. Epub 2018 Dec 29.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy.

Purpose: The role of high-flow nasal therapy (HFNT) as compared to conventional oxygen therapy (COT) in immunocompromised patients admitted to intensive care unit (ICU) with acute respiratory failure (ARF) remains unclear. We conducted a systematic review and meta-analysis in order to address this issue.

Methods: We searched PubMed, Medline and Embase until November 7th, 2018. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.015DOI Listing
April 2019
1 Read

Predatory open-access publishing in critical care medicine.

J Crit Care 2019 Apr 29;50:247-249. Epub 2018 Dec 29.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.

Purpose: To evaluate the characteristics and practice of predatory journals in critical care medicine (CCM).

Methods: We checked a freely accessible online and constantly updated version of the Beall lists of potential predatory publishers/journals in the field of CCM. We checked the journals' websites to retrieve the following data such as: 1) Country and address (checked by Google maps); 2) Article processing charges (APC); 3) Indexing; 4) Editor-in-chief and the Editorial Board (EB) members; 5) Number of published articles; 6) Review time (lapse submission-acceptance); 7) English form. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.016DOI Listing

Severity of illness assessment with application of the APACHE IV predicted mortality and outcome trends analysis in an academic cardiac intensive care unit.

J Crit Care 2019 Apr 24;50:242-246. Epub 2018 Dec 24.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. Electronic address:

Purpose: To assess trends in life support interventions and performance of the automated Acute Physiology and Chronic Health Evaluation (APACHE) IV model at mortality prediction compared with Oxford Acute Severity of Illness Score (OASIS) in a contemporary cardiac intensive care unit (CICU).

Methods And Materials: Retrospective analysis of adults (age ≥ 18 years) admitted to CICU from January 1, 2007, through December 31, 2015. Temporal trends were assessed with linear regression. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377313PMC
April 2019
1 Read

Mean arterial pressure during targeted temperature management and renal function after out-of-hospital cardiac arrest.

J Crit Care 2019 Apr 18;50:234-241. Epub 2018 Dec 18.

Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark.

Purpose: This study investigates the association between mean arterial pressure (MAP) and renal function after out-of-hospital cardiac arrest (OHCA).

Materials And Methods: Post-hoc analysis of 851 comatose OHCA-patients surviving >48 h included in the targeted temperature management (TTM)-trial.

Results: Patients were stratified by mean MAP during TTM in the following groups; <70 mmHg (22%), 70-80 mmHg (43%), and > 80 mmHg (35%). Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.009DOI Listing
April 2019
1 Read

The impact of psychological distress on long-term recovery perceptions in survivors of cardiac arrest.

J Crit Care 2019 Apr 18;50:227-233. Epub 2018 Dec 18.

Department of Neurology, Columbia University Medical Center, New York, NY, United States. Electronic address:

Purpose: To determine the association of depressive and PTSD symptoms with cardiac arrest survivors' long-term recovery perceptions, after accounting for cognitive status, functional independence, and medical comorbidities.

Methods: Perceived recovery of 78 cardiac arrest survivors at 6-months post-hospital discharge was assessed through the question, "Do you feel that you have made a complete recovery from your arrest?" Psychological symptoms were measured using the Center for Epidemiological Studies-Depression scale (CES-D) and the PTSD Checklist-Specific (PCLS). Logistic regression was utilized to assess the association between psychological symptoms with positive and negative recovery perceptions, adjusting for demographics, cognitive impairment, functional dependence, and medical comorbidities. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379069PMC
April 2019
1 Read

Effects of antibiotic prophylaxis on ventilator-associated pneumonia in severe traumatic brain injury. A post hoc analysis of two trials.

J Crit Care 2019 Apr 18;50:221-226. Epub 2018 Dec 18.

CHU Rennes, Service de Réanimation Chirurgicale, Hôpital Pontchaillou, 2 rue Henri Le Guilloux, Rennes 35000, France. Electronic address:

Purpose: To investigate the role of antibiotic prophylaxis (AP) in the incidence of ventilator-associated pneumonia (VAP) in patients suffering from traumatic brain injury (TBI).

Materials And Methods: This post hoc analysis was conducted based on data from 2 multicentre double-blind studies that aimed to prevent VAP using hydrocortisone or povidone iodine. Data from TBI patients were extracted and pooled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183072
Publisher Site
http://dx.doi.org/10.1016/j.jcrc.2018.12.010DOI Listing
April 2019
6 Reads

Prognostic nomogram for acute pancreatitis patients: An analysis of publicly electronic healthcare records in intensive care unit.

J Crit Care 2019 Apr 5;50:213-220. Epub 2018 Nov 5.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. Electronic address:

Purpose: The mortality rate of severe acute pancreatitis (AP) is 20-30% even after admission to intensive care unit (ICU). Thus we aimed to develop a laboratory-based nomogram to identify AP patients at high risk for mortality.

Materials And Methods: The primary and validation cohorts were extracted from the Medical Information Mart for Intensive Care III database (MIMIC-III). Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.10.030DOI Listing
April 2019
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Epidemiology, lung mechanics and outcomes of ARDS: A comparison between pregnant and non-pregnant subjects.

J Crit Care 2019 Apr 7;50:207-212. Epub 2018 Dec 7.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address:

Purpose: We describe the epidemiology, lung mechanics and outcomes of acute respiratory distress syndrome (ARDS) complicating pregnancy. We also compare the outcomes of ARDS in pregnant and non-pregnant females.

Methods: Retrospective observational study of all women admitted with ARDS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183085
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http://dx.doi.org/10.1016/j.jcrc.2018.12.006DOI Listing
April 2019
10 Reads
2.191 Impact Factor

Noninvasive ventilation in acute hypoxemic respiratory failure: A systematic review and meta-analysis. Response to letter.

J Crit Care 2019 Apr 3;50:310. Epub 2018 Dec 3.

Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil; CEPI - Centro de Ensino Pesquisa e Inovação -Hospital Marcelino Champagnat, Curitiba, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2018.11.035DOI Listing
April 2019
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Immature granulocytes: A novel biomarker of acute respiratory distress syndrome in patients with acute pancreatitis.

J Crit Care 2019 Apr 14;50:303-308. Epub 2018 Dec 14.

Department of Clinical Laboratory, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China. Electronic address:

Purpose: To investigate the relationship between immature granulocyte percentage (IG%) and acute respiratory distress syndrome (ARDS) in patients with acute pancreatitis (AP).

Materials And Methods: A cohort of 2289 patients with AP was screened; 1933 were enrolled in this prospective multicenter study. Blood samples for IG% analysis were collected on admission and processed using a hematology analyzer. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.002DOI Listing
April 2019
3 Reads
2.191 Impact Factor

Doppler-defined pulmonary hypertension in sepsis and septic shock.

J Crit Care 2019 Apr 8;50:201-206. Epub 2018 Dec 8.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, United States.

Background: The association of pulmonary hypertension (PH) in patients with sepsis is lesser understood.

Methods: This was a retrospective study of adult patients admitted to the intensive care unit during 2007-2014 for sepsis and septic shock, with echocardiography performed <72 h. PH was defined as tricuspid regurgitation peak velocity (TRV) > 3 m/s on Doppler echocardiography. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183093
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http://dx.doi.org/10.1016/j.jcrc.2018.12.008DOI Listing
April 2019
12 Reads
2.191 Impact Factor

μImpact of a nursing-driven sedation protocol with criteria for infusion initiation in the surgical intensive care unit.

J Crit Care 2019 Apr 30;50:195-200. Epub 2018 Nov 30.

Department of Pharmacy, The Ohio State University Wexner Medical Center, 410 W. 10th Avenue, Columbus, OH 43210, USA. Electronic address:

Purpose: Analgesia and sedation protocols (ASPs) reduce duration of mechanical ventilation (MV) in the medical intensive care unit (ICU), but data in the surgical ICU (SICU) are limited. The objective of this study was to determine the impact of a nursing-driven ASP with criteria for infusion initiation in the SICU.

Materials And Methods: A single-center, retrospective study compared ventilator-free days at day 28 from start of MV (VFD28) before and after ASP implementation. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.11.029DOI Listing

Regional differences in the treatment of refractory vasodilatory shock using Angiotensin II in High Output Shock (ATHOS-3) data.

J Crit Care 2019 Apr 8;50:188-194. Epub 2018 Dec 8.

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Emory University, Atlanta, GA, United States.

Introduction: Despite international guidelines, regional differences in treatment of vasodilatory shock remain. We characterized these differences using data from Angiotensin II in High Output Shock (ATHOS-3) trial.

Methods: The 321 patients treated in the ATHOS-3 trial were included. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.007DOI Listing
April 2019
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The state of bereavement support in adult intensive care: A systematic review and narrative synthesis.

J Crit Care 2019 Apr 1;50:177-187. Epub 2018 Dec 1.

University of Ottawa, Faculty of Health Sciences, School of Nursing, 3245B Roger Guindon Hall, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada. Electronic address:

Purpose: Despite advances in medical science, patient death and family bereavement are commonly encountered in adult intensive care units (ICUs). This is the first review to investigate the state of ICU bereavement support globally, and the availability and effectiveness of bereavement support interventions.

Methods: A systematic review and narrative synthesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183140
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http://dx.doi.org/10.1016/j.jcrc.2018.11.026DOI Listing
April 2019
14 Reads

Risk factors for mortality and cost implications of complicated intra-abdominal infections in critically ill patients.

J Crit Care 2019 Apr 12;50:169-176. Epub 2018 Dec 12.

Dipartimento di Scienza dell'Emergenza, Anestesiologiche e della Rianimazione - UOC di Anestesia, Rianimazione, Terapia Intensiva e Tossicologia Clinica - Istituto di Anestesia e Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma - Università Cattolica del Sacro Cuore, Italy. Electronic address:

Purpose: To assess risk factors for 28-day mortality and cost implications in intensive care unit (ICU) patients with complicated intra-abdominal infections (cIAIs).

Methods: Single-center retrospective cohort study of prospectively collected data analysing ICU patients with a microbiologically confirmed complicated intra-abdominal infections.

Results: 137 complicated intra-abdominal infections were included and stratified according to the adequacy of antimicrobial therapy (initial inadequate antimicrobial therapy [IIAT], n = 44; initial adequate antimicrobial therapy [IAAT], n = 93). Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.001DOI Listing
April 2019
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Effects of antiplatelet therapy on the mortality rate of patients with sepsis: A meta-analysis.

J Crit Care 2019 Apr 5;50:162-168. Epub 2018 Dec 5.

Department of Intensive Care Unit, The First Hospital of China Medical University, Nanjing Bei Street 155, Shenyang 110001, Liaoning Province, PR China. Electronic address:

Purpose: Abnormal platelet activation plays an important role in the development of sepsis. The effect of antiplatelet drugs on the outcome of patients with sepsis remains unclear. This meta-analysis aimed to determine the effect of antiplatelet drugs on the prognosis of patients with sepsis. Read More

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http://dx.doi.org/10.1016/j.jcrc.2018.12.004DOI Listing

Ventilator-associated pneumonia: The central role of transcolonization.

J Crit Care 2019 Apr 6;50:155-161. Epub 2018 Dec 6.

Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France; Endotoxins, Structures and Host Response, Department of Microbiology, Institute for Integrative Biology of the Cell, UMR 9891 CNRS-CEA-Paris Saclay University, 98190 Gif-sur-Yvette, France. Electronic address:

Ventilator-associated pneumonia remain frequent and serious diseases since they are associated with considerable crude mortality. Pathophysiology is centered on modifications of regional bacterial flora, especially tracheobronchial tree and oropharyngeal sphere. Bacterial migration from an anatomical area to another seems to be the main explanation of these alterations which are called "transcolonization". Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183061
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http://dx.doi.org/10.1016/j.jcrc.2018.12.005DOI Listing
April 2019
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Crystalloids vs. colloids for fluid resuscitation in the Intensive Care Unit: A systematic review and meta-analysis.

J Crit Care 2019 Apr 30;50:144-154. Epub 2018 Nov 30.

Meridian HealthComms, Plumley Moor Road, Plumley, UK. Electronic address:

Purpose: Guidelines recommend crystalloids for fluid resuscitation in sepsis/shock and switching to albumin in cases where crystalloids are insufficient. We evaluated hemodynamic response to crystalloids/colloids in critically ill adults.

Materials And Methods: The primary research question was: "Are crystalloids sufficient for volume replacement in severe indications (intensive care unit [ICU]/critical illness)?" Randomized, controlled trials (RCTs) were identified using PubMed and EMBASE, and screened against predefined inclusion/exclusion criteria. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183108
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http://dx.doi.org/10.1016/j.jcrc.2018.11.031DOI Listing
April 2019
3 Reads