152,743 results match your criteria Journal of Couple & Relationship Therapy [Journal]


The formation of the Thickveins (Tkv) gradient in Drosophila wing discs: A theoretical study.

Authors:
Zhan Chen

J Theor Biol 2019 Apr 15. Epub 2019 Apr 15.

Department of Mathematical Sciences, Georgia Southern University, Statesboro, GA, United States.

The development of wing imaginal disc (wing disc) is commonly adopted for the studies of patterning and growth which are two fundamental problems in developmental biology. Decapentaplegic (Dpp) signaling regulates several aspects of wing development, such as the anterior (A)-posterior (P) patterning, cellular growth rate, and cell adhesion. The distribution and activity of Dpp signaling are controlled in part by the expression level of its major type I receptor, Thickveins (Tkv). Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.015DOI Listing

Efficient electrocatalytic hydrogenation with a palladium membrane reactor.

J Am Chem Soc 2019 Apr 17. Epub 2019 Apr 17.

We report here the advantages of using a palladium membrane reactor to drive hydrogenation chemistry with electricity while bypassing the formation of gaseous H. This technique uses a palladium membrane to physically separate the electrochemical and hydrogenation chemistry. As a result, hydrogenation can be performed electrochemically with protons but in any organic solvent. Read More

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http://dx.doi.org/10.1021/jacs.9b01442DOI Listing

Experiences of Patients With a Diabetes Self-Care App Developed Based on the Information-Motivation-Behavioral Skills Model: Before-and-After Study.

JMIR Diabetes 2019 Apr 18;4(2):e11590. Epub 2019 Apr 18.

College of Nursing, Seoul National University, Seoul, Republic of Korea.

Background: Mobile phones have been actively used in various ways for diabetes self-care. Mobile phone apps can manage lifestyle factors such as diet, exercise, and medication without time or place restrictions. A systematic review has found these apps to be effective in reducing blood glucose. Read More

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http://dx.doi.org/10.2196/11590DOI Listing

Toxicology in the Super-Resolution Era.

Authors:
Richard Cole

Curr Protoc Toxicol 2019 Apr 18:e77. Epub 2019 Apr 18.

Wadsworth Center, New York State Department of Health, Albany, New York.

Light microscopy has played a central role in science for the past couple of hundred years and will continue to do so. Multiple super-resolution microscopy techniques have been in the headlines for smashing what for more than 100+ years was believed to be the limits of optical microscopy. This resolution improvement enables the visualization of molecular structures and processes on the nano scale. Read More

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http://dx.doi.org/10.1002/cptx.77DOI Listing

The Influence of Proinflammatory Cytokines on Voriconazole Trough Concentration in Patients With Different Forms of Hematologic Disorders.

J Clin Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Even though multiple factors are involved in the high fluctuation of voriconazole (VCZ) plasma concentration, little is known regarding the influence of proinflammatory cytokines on VCZ concentration. The aim of this study was to investigate the influence of proinflammatory cytokines, namely, interleukin (IL)-1β, IL-6, IL-18, interferon-γ, tumor necrosis factor-α, and transforming growth factor (TGF)-β1 on VCZ trough concentration (VCZ-C ) in Chinese patients with different forms of hematologic disorders. A total of 250 plasma samples from 113 patients were analyzed for VCZ-C and proinflammatory cytokines using a validated liquid chromatography-tandem mass spectrometry and enzyme-linked immunosorbent assay methods, respectively. Read More

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http://dx.doi.org/10.1002/jcph.1422DOI Listing

Beyond checkboxes: A qualitative assessment of physicians' experiences providing care in a patient-centred medical home.

J Eval Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Department of Family Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.

Rationale, Aims, And Objectives: The patient-centred medical home (PCMH) is an innovative approach to health care reform. Despite a well-established process for recognizing PCMH practices, fidelity to, and/or adaptation of, the PCMH model can limit health care and population health improvements. This study explored the connection between fidelity/adaptation to the PCMH model with implementation successes and challenges through the experiences of family and internal medicine PCMH physicians. Read More

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http://dx.doi.org/10.1111/jep.13136DOI Listing

Demethylation and desulfonation of textile industry dye, Thiazole Yellow G by LAG.

Biotechnol Rep (Amst) 2019 Sep 28;23:e00327. Epub 2019 Mar 28.

Department of Earth Resources and Environmental Engineering, Hanyang University, Seoul, 04763, South Korea.

Filamentous fungi perform tremendously in adsorption of dyes from polluted environment. In this study, LAG decolorized thiazole yellow G dye within 5 days. Scale up studies done revealed that maximum decolorization (98%) was achieved at a concentration (10 mg L), temperature (35 °C) and pH 6. Read More

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http://dx.doi.org/10.1016/j.btre.2019.e00327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451163PMC
September 2019

Solar electricity and fuel production with perylene monoimide dye-sensitised TiO in water.

Chem Sci 2019 Mar 21;10(9):2758-2766. Epub 2018 Dec 21.

Christian Doppler Laboratory for Sustainable SynGas Chemistry , Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , UK . Email:

Dye-sensitisation of TiO and other metal oxides is an established strategy to couple solar light harvesting with efficient charge separation for the production of electricity in dye-sensitised solar cells (DSCs) or fuels in dye-sensitised semiconductor photocatalysis (DSP). Perylene monoimide (PMI) dyes have emerged as promising organic dyes, but they have not previously been used in a functional assembly with TiO in aqueous solution. Here, five novel PMI dyes bearing carboxylic acid, phosphonic acid, acetylacetone, hydroxyquinoline or dipicolinic acid anchoring groups for attachment onto TiO are reported. Read More

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http://xlink.rsc.org/?DOI=C8SC05693E
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http://dx.doi.org/10.1039/c8sc05693eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419928PMC
March 2019
1 Read

Symmetry breaking and the turn-on fluorescence of small, highly strained carbon nanohoops.

Chem Sci 2019 Apr 25;10(13):3786-3790. Epub 2019 Feb 25.

Department of Chemistry & Biochemistry , Materials Science Institute , University of Oregon , Eugene , Oregon 97403 , USA . Email:

[]Cycloparaphenylenes, or "carbon nanohoops," are unique conjugated macrocycles with radially oriented π-systems similar to those in carbon nanotubes. The centrosymmetric nature and conformational rigidity of these molecules lead to unusual size-dependent photophysical characteristics. To investigate these effects further and expand the family of possible structures, a new class of related carbon nanohoops with broken symmetry is disclosed. Read More

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http://dx.doi.org/10.1039/c9sc00169gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446961PMC

Bimetallic nickel-lutetium complexes: tuning the properties and catalytic hydrogenation activity of the Ni site by varying the Lu coordination environment.

Chem Sci 2019 Mar 4;10(11):3375-3384. Epub 2019 Feb 4.

Department of Chemistry , University of Minnesota , Minneapolis , Minnesota 55455-0431 , USA . Email:

We present three heterobimetallic complexes containing an isostructural nickel center and a lutetium ion in varying coordination environments. The bidentate and nonadentate ligands were used to prepare the Lu metalloligands, Lu(PrPCHNPh) () and Lu{(PrPCHNAr)tacn} (), respectively. Reaction of Ni(COD) (where COD is 1,5-cyclooctadiene) and afforded NiLu(PrPCHNPh) (), with a Lu coordination number (CN) of 4 and a Ni-Lu distance, (Ni-Lu), of 2. Read More

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http://xlink.rsc.org/?DOI=C8SC04712J
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http://dx.doi.org/10.1039/c8sc04712jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429466PMC
March 2019
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B- and N-embedded color-tunable phosphorescent iridium complexes and B-N Lewis adducts with intriguing structural and optical changes.

Chem Sci 2019 Mar 18;10(11):3257-3263. Epub 2019 Jan 18.

School of Material Science and Engineering , Jiangsu University of Science and Technology , Zhenjiang 212003 , P. R. China . Email: ; Email:

A novel family of B- and N-embedded phosphorescent iridium complexes has been prepared. Single crystal structures indicate that the B-embedded polycyclic unit exhibits better planarity than the N-embedded polycyclic unit, which leads to different π-π-stacking and electrical characteristics. More importantly, by controlling the number of boron or nitrogen atoms embedded, solution-processed OLED devices incorporating these emitters as emitting layers can achieve a phosphorescence color variation from green to deep red (638 nm) and show low-efficiency roll-off and turn-on voltage. Read More

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http://dx.doi.org/10.1039/c8sc04252gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429608PMC

Coupling Supervised Molecular Dynamics (SuMD) with Entropy Estimations To Shine Light on the Stability of Multiple Binding Sites.

ACS Med Chem Lett 2019 Apr 15;10(4):444-449. Epub 2019 Feb 15.

Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35122 Padova, Italy.

Exploring at the molecular level, all possible ligand-protein approaching pathways and, consequently, identifying the energetically favorable binding sites is considered crucial to depict a clear picture of the whole scenario of ligand-protein binding. In fact, a ligand can recognize a protein in multiple binding sites, adopting multiple conformations in every single binding site and inducing protein modifications upon binding. In the present work, we would like to present how it is possible to couple a supervised molecular dynamics (SuMD) approach to explore, from an unbound state, the most energetically favorable recognition pathways of the ligand to its protein, with an enthalpic and entropic characterization of the most stable ligand-protein bound states, using the protein kinase CK2α as a prototype study. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466520PMC

[Characteristics analysis of early gastric cancer under white light endoscopy].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):302-306

Department of gastroenterology,Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate endoscopic features of early gastric cancer and clinical features of the patients, which may be helpful to provide reasonable suggestions for physicians to diagnose early gastric cancer during preliminary screening of white light gastroscopy.

Methods: A total of 271 patients who received endoscopic submucosal dissection or surgical operation to confirm early gastric cancer in Peking University Third Hospital from Apr. 2009 to Jun. Read More

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LRSAM1 variants and founder effect in French families with ataxic form of Charcot-Marie-Tooth type 2.

Eur J Hum Genet 2019 Apr 17. Epub 2019 Apr 17.

AP-HP, G-H Pitié-Salpêtrière, Centre de Référence des Maladies neuromusculaires, Paris Nord/Est/Ile de france, Paris, France.

Currently only 25-30% of patients with axonal forms of Charcot-Marie-Tooth disease (CMT) receive a genetic diagnosis. We aimed to identify the causative gene of CMT type 2 in 8 non-related French families with a distinct clinical phenotype. We collected clinical, electrophysiological, and laboratory findings and performed genetic analyses in four different French laboratories. Read More

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http://dx.doi.org/10.1038/s41431-019-0403-8DOI Listing

Terahertz electromagnetically-induced transparency of self-complementary meta-molecules on Croatian checkerboard.

Sci Rep 2019 Apr 17;9(1):6205. Epub 2019 Apr 17.

Department of Physics, Shanghai Normal University, Shanghai, 200234, China.

A terahertz (THz) electromagnetically-induced transparency (EIT) phenomenon is observed from two types of self-complementary meta-molecules (MMs) based on rectangular shaped electric split-ring resonators (eSRR) on Croatian checkerboard. Each MM contains a couple of identical size eSRRs and a couple of structural inversed eSRRs twisted π/2 in checkerboard pattern. In the first type of MM (type-I), the gap is in the middle line of eSRR. Read More

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http://dx.doi.org/10.1038/s41598-019-42038-8DOI Listing

Patterns of support to adolescents related to disability, family situation, harassment and economy.

Child Care Health Dev 2019 Apr 17. Epub 2019 Apr 17.

CHILD Research Group, Department of Nursing Science, School of Health and Welfare, Jönköping University, Jönköping, Sweden.

Introduction: Adolescents need support from family, friends and teachers to increase their involvement in everyday life. Their environment and their own characteristics also influence their ability to participate in an everyday supportive environment.

Aim: The aim of the study was to investigate patterns of support from parents, teachers and very important persons such as peers to the ability of adolescents to participate in everyday life, as well as the importance of interpersonal relations as experienced by the adolescents. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cch.12675
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http://dx.doi.org/10.1111/cch.12675DOI Listing
April 2019
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The 2017 human monkeypox outbreak in Nigeria-Report of outbreak experience and response in the Niger Delta University Teaching Hospital, Bayelsa State, Nigeria.

PLoS One 2019 17;14(4):e0214229. Epub 2019 Apr 17.

Nigerian Centre for Disease Control, Abuja, Nigeria.

Background: In September 2017, Nigeria experienced a large outbreak of human monkeypox (HMPX). In this study, we report the outbreak experience and response in the Niger Delta University Teaching Hospital (NDUTH), Bayelsa state, where the index case and majority of suspected cases were reported.

Methods: In a cross-sectional study between September 25th and 31st December 2017, we reviewed the clinical and laboratory characteristics of all suspected and confirmed cases of HMPX seen at the NDUTH and appraised the plans, activities and challenges of the hospital in response to the outbreak based on documented observations of the hospital's infection control committee (IPC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214229PLOS

Screen-time is associated with inattention problems in preschoolers: Results from the CHILD birth cohort study.

PLoS One 2019 17;14(4):e0213995. Epub 2019 Apr 17.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Background: Pre-school children spend an average of two-hours daily using screens. We examined associations between screen-time on pre-school behavior using data from the Canadian Healthy Infant Longitudinal Development (CHILD) study.

Methods: CHILD participant parents completed the Child Behavior Checklist (CBCL) at five-years of age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213995PLOS

Prevalence and determinants of poor quality of sleep among adolescents in rural Puducherry, South India.

Int J Adolesc Med Health 2019 Apr 17. Epub 2019 Apr 17.

Department of Preventive and Social Medicine, Jawaharlal Institute of Post Graduate Medical Education, Pondicherry, India.

Background Adolescence is a critical stage of life which is characterized by rapid biological, social and emotional development. India has the highest adolescent population, however, there is paucity of literature reporting the sleep quality among adolescents. Objective To determine the sleep quality and its associated factors among adolescents residing in selected villages of rural Puducherry. Read More

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http://www.degruyter.com/view/j/ijamh.ahead-of-print/ijamh-2
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http://dx.doi.org/10.1515/ijamh-2018-0101DOI Listing
April 2019
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Broader autism phenotype and couple interactions in parents of children with autism.

Autism 2019 Apr 17:1362361319841312. Epub 2019 Apr 17.

University of Wisconsin-Madison, USA.

The broader autism phenotype refers to sub-clinical autism spectrum disorder characteristics involving socially and emotionally aloof and rigid personality traits and social communication difficulties. Relatives of individuals with autism spectrum disorder, including parents, evidence an increased rate of broader autism phenotype. The goal of this study was to evaluate the association between actor (one's own) and partner (their partner's) broader autism phenotype and the self-reported, observed, and physiological (i. Read More

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http://dx.doi.org/10.1177/1362361319841312DOI Listing
April 2019
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Vaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV.

Curr Opin HIV AIDS 2019 Apr 15. Epub 2019 Apr 15.

Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai.

Purpose Of Review: In humans, only one independent immunologic correlate of reduced risk of HIV infection has been identified: a robust antibody (Ab) response to the V1V2 domain of the gp120 envelope (Env) protein. In recent years, the presence and level of V1V2-specific Abs has also been correlated with protection from SIV and SHIV infections. Here, we review the multitude of studies showing the in-vivo protective effects of V1V2 Abs and review their immunologic characteristics and antiviral functions. Read More

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http://dx.doi.org/10.1097/COH.0000000000000551DOI Listing

Racial and Ethnic Disparities in Desire for Reversal of Sterilization Among U.S. Women.

J Womens Health (Larchmt) 2019 Apr 17. Epub 2019 Apr 17.

1 Department of Sociology, Portland State University, Portland, Oregon.

Racial and ethnic disparities in rates of female sterilization, a prominent method of contraception, have been consistently observed for decades. Such disparities are also evident in subsequent desire for reversal of the procedure. Additional work is needed to better understand these patterns, particularly given the historical context of coercive sterilization patterns in minority and low-income women. Read More

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https://www.liebertpub.com/doi/10.1089/jwh.2018.7157
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http://dx.doi.org/10.1089/jwh.2018.7157DOI Listing
April 2019
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Dyadic associations between perceived social support and cancer patient and caregiver health: An Actor-Partner Interdependence modeling approach.

Psychooncology 2019 Apr 16. Epub 2019 Apr 16.

Smith Center for Healing and the Arts, Washington, D.C.

Objective: Social support may have a positive impact on health outcomes for patients and caregivers, but the extent to which social support and health outcomes are interrelated for both is unknown. We examine the dyadic interrelationships between social support and health among cancer patients and their caregivers.

Methods: Lung and colorectal cancer (CRC) patient and caregiver dyadic data were obtained from the Cancer Care Outcomes Research and Surveillance Consortium. Read More

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http://dx.doi.org/10.1002/pon.5096DOI Listing

Characteristics of melanoma in white and nonwhite children, adolescents, and young adults: Analysis of a pediatric melanoma institutional registry, 1995-2018.

Pediatr Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Stanford University Medical Center, Pigmented Lesion and Melanoma Program, Stanford University Medical Center and Cancer Institute, Lucile Packard Children's Hospital, Stanford, California.

Objectives: To characterize clinical differences among nonwhite/multiethnic vs white children, adolescents, and young adults with melanoma or atypical melanocytic neoplasms, including atypical Spitz tumors.

Patients And Methods: A cohort of 55 patients (< 25 years of age) prospectively followed from 1995 to 2018 in the Stanford Pigmented Lesion and Melanoma Program was analyzed for differences in clinical presentation, including skin phototype, race/ethnicity, age, sex, tumor/melanoma characteristics, and outcome.

Results: Seventeen patients (9 males and 8 females) were classified as nonwhite (predominantly skin phototype IV) and of Hispanic, Asian, or Black/African American ethnicity, and 38 patients (21 males and 17 females) were classified as white (predominantly phototypes I/II). Read More

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http://dx.doi.org/10.1111/pde.13836DOI Listing

Household food insecurity and socio-demographic determinants in young adults: findings from a Portuguese population-based sample.

Int J Public Health 2019 Apr 16. Epub 2019 Apr 16.

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, nº 135, 4050-600, Porto, Portugal.

Objectives: This study evaluated the prevalence and the socio-demographic determinants of food insecurity among young adults at a time of economic crisis recovery.

Methods: A cross-sectional study including 954 young adults (26 years old) from the EPITeen cohort (Porto, Portugal) was conducted. Food security status was evaluated using the US Household Food Security Survey Module: Six-Item Short Form. Read More

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http://dx.doi.org/10.1007/s00038-019-01243-yDOI Listing

Changes in patterns of retention in HIV care and antiretroviral treatment in Tanzania between 2008 and 2016: an analysis of routinely collected national programme data.

J Glob Health 2019 Jun;9(1):010424

Strategic Information Unit, National AIDS Control Programme, Dodoma Tanzania.

Background: Tanzania is a high HIV burden country in Sub-Saharan Africa with 1.5 million people infected. Unless monitored and responded to, low levels of retention in care may lead to poor HIV associated clinical outcomes and an increased likelihood of onward viral transmission. Read More

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http://dx.doi.org/10.7189/jogh.09.010424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445500PMC

Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH.

J Biol Chem 2019 Apr 16. Epub 2019 Apr 16.

Cell & Tissue Biology, University of California, San Francisco, United States.

Tau, a member of the MAP2/tau family of microtubule-associated proteins, stabilizes and organizes axonal microtubules in healthy neurons. In neurodegenerative tauopathies, tau dissociates from microtubules and forms neurotoxic extracellular aggregates. MAP2/tau family proteins are characterized by three to five conserved, intrinsically disordered repeat regions that mediate electrostatic interactions with the microtubule surface. Read More

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http://dx.doi.org/10.1074/jbc.RA118.007004DOI Listing

Starvation-induced autophagy is upregulated via ROS-mediated ClC-3 chloride channel activation in the nasopharyngeal carcinoma cell line CNE-2Z.

Biochem J 2019 Apr 16. Epub 2019 Apr 16.

Department of Physiology, Jinan University, Jinan University, 601 Huangpu Avenue West, Guangzhou, 510632, China.

Nutrient deficiency develops frequently in nasopharyngeal carcinoma cell (CNE-2Z) due to the characteristics of aggregation and uncontrolled proliferation. Therefore, starvation can induce autophagy in these cells. Chloride channel3 (ClC-3), a member of the chloride channel family, is involved in various biological processes. Read More

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http://dx.doi.org/10.1042/BCJ20180979DOI Listing

Antenatal care and skilled birth attendance in Bangladesh are influenced by female education and family affordability: BDHS 2014.

Public Health 2019 Apr 13;170:113-121. Epub 2019 Apr 13.

Department of Statistics Data Science and Epidemiology, Swinburne University of Technology, Australia. Electronic address:

Objectives: Antenatal care (ANC) during pregnancy and skilled birth attendance (SBA) during delivery are important policy concerns to reduce maternal deaths. Bangladesh is one of the developing countries which has made remarkable progress in both services during the last couple of decades by improving the SBA service rate from 16% in 2004 to 42.1% in 2014. Read More

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http://dx.doi.org/10.1016/j.puhe.2019.02.027DOI Listing

BR2 and CyLoP1 enhance in-vivo SN38 delivery using pegylated PAMAM dendrimers.

Int J Pharm 2019 Apr 13. Epub 2019 Apr 13.

Nanotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

The usage of 7-Ethyl-10-hydroxy-camptothecin (SN38) as the most biologically active member of camptothecin family is restricted because of its poor solubility in pharmaceutical solvents. Polyamidoamine (PAMAM) dendrimers, can be used as suitable drug delivery carrier for poorly water soluble molecules. In this study, we prepared two cell penetrating peptides (BR2 and CyLoP1) conjugated formulations of PEGylated PAMAM containing SN38. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193029
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http://dx.doi.org/10.1016/j.ijpharm.2019.04.037DOI Listing
April 2019
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Next generation sequencing in recurrent pregnancy loss-approaches and outcomes.

Eur J Med Genet 2019 Apr 13. Epub 2019 Apr 13.

Department of Pathology and Laboratory Medicine, University of British Columbia and, Child and Family Research Institute, 950 West 28th, Vancouver BC, Canada. Electronic address:

Next generation sequencing (NGS) has revolutionized the diagnosis of postnatal genetic diseases, but so far has been used less frequently to study reproductive disorders. Here we provide an overview of approaches and outcomes of genome sequencing for identifying causes of recurrent pregnancy loss (RPL). This includes exome sequencing to look for pathogenic sequence changes in the whole exome or in a preselected list of genes considered important for early embryonic development and pregnancy maintenance, as well as low coverage whole genome sequencing useful for identifying cryptic balanced chromosome rearrangements and copy number variants (CNVs) in couples with RPL and miscarriages. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.04.001DOI Listing

Epigenetic therapies in heart failure.

J Mol Cell Cardiol 2019 Apr 13. Epub 2019 Apr 13.

Gladstone Institutes, San Francisco, CA, United States of America; Division of Cardiology, Department of Medicine, University of California San Francisco School of Medicine, San Francisco, CA, United States of America; Cardiometabolic Disorders, Amgen, South San Francisco, CA, United States of America. Electronic address:

Heart failure (HF) is a dominant cause of morbidity and mortality in the developed world. Currently available pharmacotherapies for HF, which largely comprise blockade of circulating neurohormones, are limited by high rates of residual mortality and do not directly target the fundamental changes in cell state that drive adverse cardiac remodeling. In the context of HF, stress-activated cardiac signaling cascades converge on defined components of the chromatin regulatory apparatus in the nucleus, triggering broad shifts in transcription and cell state, events which fuel the vicious cycle of pathological cardiac remodeling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00222828193006
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http://dx.doi.org/10.1016/j.yjmcc.2019.04.012DOI Listing
April 2019
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Risk behaviors among Italian healthcare students: a cross-sectional study for health promotion of future healthcare workers.

Med Lav 2019 Apr 19;110(2):155-162. Epub 2019 Apr 19.

School of Medicine and Surgery, University of Milano Bicocca.

Background: Risk behaviors are frequent among young adults and they are particularly relevant when considering healthcare students.

Objectives: The study is aimed to examine the prevalence of smoking, binge drinking, physical inactivity, and excessive bodyweight in a population of healthcare students attending an Italian university.

Methods: Healthcare students filled an anonymous multiple-choice questionnaire on the occasion of the occupational health visit that preceded their hospital internship. Read More

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http://dx.doi.org/10.23749/mdl.v110i2.7573DOI Listing

Uptake and Scalability of a Peritoneal Dialysis Virtual Care Solution: Qualitative Study.

JMIR Hum Factors 2019 Apr 16;6(2):e9720. Epub 2019 Apr 16.

Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Background: Early research in the area of virtual care solutions with peritoneal dialysis (PD) patients has focused on evaluating the outcomes and impact of these solutions. There has been less attention focused on understanding the factors influencing the uptake, usability, and scalability of virtual care for chronic kidney disease (CKD) patients receiving PD at home.

Objective: In this context, a study was undertaken to (1) assess and understand the factors influencing the uptake of a virtual care solution and (2) provide recommendations for the scalability of a virtual care solution aimed at enhancing CKD patients' outcomes and experiences. Read More

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https://humanfactors.jmir.org/2019/2/e9720/
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http://dx.doi.org/10.2196/humanfactors.9720DOI Listing
April 2019
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Prevalence of depressive symptoms and its associated factors among healthy community-dwelling older adults living in Australia and the United States.

Int J Geriatr Psychiatry 2019 Apr 16. Epub 2019 Apr 16.

School of Medicine, IMPACT Strategic Research Centre, Deakin University, Geelong, Australia.

Objective: This study was conducted to estimate prevalence rates and factors associated with depressive symptoms indexed by the Centre for Epidemiological Studies - Depression (CES-D-10) score in a large sample of community-dwelling healthy older adults from Australia and the United States. Convergent and divergent validity of the CES-D-10 were also examined.

Methods: A total of 19,114 individuals aged ≥65 years were enrolled from a primary prevention clinical trial. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/gps.5119
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http://dx.doi.org/10.1002/gps.5119DOI Listing
April 2019
1 Read

Communication channels for air quality alerts in the United States.

Prev Med Rep 2019 Jun 28;14:100860. Epub 2019 Mar 28.

Asthma and Community Health Branch, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F-60, Atlanta, GA 30341, USA.

Short-term exposure to air pollution can result in acute health effects, particularly for individuals with respiratory and cardiovascular disease. Air quality alert programs that notify the public about high air pollution days are critical for susceptible populations. We assessed how U. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113355193004
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http://dx.doi.org/10.1016/j.pmedr.2019.100860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449704PMC
June 2019
1 Read

Effect of asiatic acid on epithelial-mesenchymal transition of human alveolar epithelium A549 cells induced by TGF-β1.

Oncol Lett 2019 May 12;17(5):4285-4292. Epub 2019 Mar 12.

Department of Respiration, The First Affiliated Hospital of Henan University of CM, Zhengzhou, Henan 450000, P.R. China.

Asiatic acid (AA) is a pentacyclic triterpenoid isolated from (L.) Urban that possesses significant antitumor activities. In the present study, the mechanism of AA on transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) was investigated in the lung cancer cell line A549. Read More

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http://dx.doi.org/10.3892/ol.2019.10140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447948PMC

The association between demographic and familial characteristics and psychological properties of adolescents.

J Res Med Sci 2019 25;24:14. Epub 2019 Feb 25.

Department of Epidemiology and Biostatistics, Faculty of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: We aimed to investigate the association between demographic and familial characteristics and psychological properties of adolescents including identity style, spiritual intelligence (SI), perceived parenting style (PPS), family functioning, and mental health.

Materials And Methods: In this cross-sectional study, high school students aged 15-18 years were enrolled. Demographic characteristics of each student and their parents were recorded. Read More

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http://www.jmsjournal.net/text.asp?2019/24/1/14/252885
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http://dx.doi.org/10.4103/jrms.JRMS_444_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421974PMC
February 2019
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Navigating intimate sexual partnerships in an era of HIV: dimensions of couple relationship quality and satisfaction among adults in Eswatini and linkages to HIV risk.

SAHARA J 2019 Dec;16(1):10-24

e Johns Hopkins University Bloomberg School of Public Health, International Health , Baltimore , MD , USA.

Couple relationship functioning impacts individual health and well-being, including HIV risk, but scant research has focused on emic understandings of relationship quality in African populations. We explored relationship quality and satisfaction in Eswatini (formerly Swaziland) using data from 148 in-depth interviews (117 life-course interviews with 28 adults and 31 interviews with 29 marriage counselors and their clients) and 4 focus group discussions. Love, respect, honesty, trust, communication, sexual satisfaction, and sexual faithfulness emerged as the most salient characteristics of good relationships, with both men and women emphasising love and respect as being most important. Read More

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https://www.tandfonline.com/doi/full/10.1080/17290376.2019.1
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http://dx.doi.org/10.1080/17290376.2019.1604254DOI Listing
December 2019
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Development of a New Ex Vivo Lipolysis-Absorption Model for Nanoemulsions.

Pharmaceutics 2019 Apr 4;11(4). Epub 2019 Apr 4.

School of Health Sciences, Macao Polytechnic Institute, Macau 999078, China.

The use of lipid-based formulations (LBFs) in improving the absorption of poorly water-soluble drugs has now well established. Because the in vivo evaluation of LBFs is labor-intensive, in vitro or ex vivo approaches could provide advantages. In this study, a new ex vivo lipolysis-absorption model (LAM) composed of an intestinal digestion system and an intestinal tissue system was developed to evaluate and predict the in vivo absorption performances of LBFs. Read More

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https://www.mdpi.com/1999-4923/11/4/164
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http://dx.doi.org/10.3390/pharmaceutics11040164DOI Listing
April 2019
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Levels of Satisfaction, Workload Stress and Support Amongst Informal Caregivers of Patients Receiving or Not Receiving Long-Term Home Nursing Care in Poland: A Cross-Sectional Study.

Int J Environ Res Public Health 2019 Apr 2;16(7). Epub 2019 Apr 2.

Department of Primary Health Care, Medical University of Bialystok, 15-054 Bialystok, Poland.

The role of informal caregivers was included in the Assumptions of the Long-Term Senior Policy in Poland for 2014-2020. The document acknowledged the necessity of diagnosing the needs of informal caregivers of elderly people and to implement systemic solutions that would enable the provision of assistance for them. In response, this study aimed to describe the situation of caregivers of patients receiving versus patients not receiving Long-Term Home Nursing Care (LTHNC; i. Read More

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http://dx.doi.org/10.3390/ijerph16071189DOI Listing

Single self-assembled InAs/GaAs quantum dots in photonic nanostructures: The role of nanofabrication.

Phys Rev Appl 2018 ;9

Center for Nanoscale Science and Technology, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

Single self-assembled InAs/GaAs quantum dots are a promising solid-state quantum technology, with which vacuum Rabi splitting, single-photon-level nonlinearities, and bright, pure, and indistinguishable single-photon generation having been demonstrated. For such achievements, nanofabrication is used to create structures in which the quantum dot preferentially interacts with strongly-confined optical modes. An open question is the extent to which such nanofabrication may also have an adverse influence, through the creation of traps and surface states that could induce blinking, spectral diffusion, and dephasing. Read More

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http://dx.doi.org/10.1103/PhysRevApplied.9.064019DOI Listing
January 2018

Comparison of clinical characteristics and outcomes between homeless and non-homeless patients admitted to intensive care units: An observational propensity-matched cohort study in Korea.

J Crit Care 2019 Apr 3;52:80-85. Epub 2019 Apr 3.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea. Electronic address:

Purpose: To compare clinical characteristics and outcomes between critically ill homeless and non-homeless patients admitted to the intensive care unit (ICU) in a Korea.

Materials And Methods: We retrospectively analyzed the medical charts of homeless and non-homeless patients admitted to ICU at Seoul Boramae Medical Center between January 2012 and December 2017. Patients were selected using 1: 2 propensity score matching including age, sex, and type of ICU and multivariate analyses were performed to determine risk factors for hospital and ICU mortality. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.04.005DOI Listing

Distal Outflow-related Anterior Inferior Cerebellar Artery Aneurysm in Hemangioblastoma.

World Neurosurg 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurosurgery, SanBo Brain Hospital, Capital Medical University. Electronic address:

Anterior inferior cerebellar artery (AICA) aneurysm is a rare cerebral entity and its presentation in association with a hyper-vascularized tumor is even more exceptional. In this study, we presented a patient with rare coexistent pathologies in combination of a cerebellar hypervascularized tumor with an outflow related AICA aneurysm. A one-stage procedure to remove both lesions was carried out following meticulous discussion with patient. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.023DOI Listing

An insight into the dependence of the deamination rate of human APOBEC3F on the length of single-stranded DNA, which is affected by the concentrations of APOBEC3F and single-stranded DNA.

Biochim Biophys Acta Gen Subj 2019 Apr 12. Epub 2019 Apr 12.

Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto, Japan; Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto, Japan. Electronic address:

Background: APOBEC3F (A3F), a member of the human APOBEC3 (A3) family of cytidine deaminases, acts as an anti-HIV-1 factor by deaminating deoxycytidine in the complementary DNA of the viral genome. A full understanding of the deamination behavior of A3F awaits further investigation.

Methods: The real-time NMR method and uracil-DNA glycosylase assay were used to track the activities of the C-terminal domain (CTD) of A3F at different concentrations of A3F-CTD and ssDNA. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.04.011DOI Listing

Evaluation of a rapid and automated heparin-induced thrombocytopenia immunoassay.

Int J Lab Hematol 2019 Apr 15. Epub 2019 Apr 15.

Florida Hospital Center for Thrombosis Research, Winter Park, Florida.

Introduction: Heparin-induced thrombocytopenia (HIT) is a potentially life-threatening adverse reaction of heparin. Laboratory evaluation of HIT is often not available within a reasonable time. We evaluated the HemosIL HIT-Ab (Instrumentation Laboratory), a rapid, on-demand, fully automated, latex immunoturbidimetric assay (LIA). Read More

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http://dx.doi.org/10.1111/ijlh.13029DOI Listing
April 2019
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Duration of Oxaliplatin-Containing Adjuvant Therapy for Stage III Colon Cancer: ASCO Clinical Practice Guideline.

J Clin Oncol 2019 Apr 15:JCO1900281. Epub 2019 Apr 15.

15 St Michael's Hospital, Toronto, Ontario, Canada.

Purpose: To develop recommendations for duration of adjuvant chemotherapy with a fluoropyrimidine and oxaliplatin for patients with completely resected stage III colon cancer based on the results of trials of 3 months compared with 6 months of treatment.

Methods: ASCO convened an Expert Panel and conducted a systematic review of relevant studies. The guideline recommendations were based on the review of evidence by the Expert Panel. Read More

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http://dx.doi.org/10.1200/JCO.19.00281DOI Listing

Depressive symptom contagion in the transition to parenthood: Interparental processes and the role of partner-related attachment.

J Abnorm Psychol 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychology.

How depressive symptoms unfold within a couple during the perinatal events of pregnancy, childbirth, and early parenthood is poorly understood. In this prospective study, we aim to investigate the reciprocal relation between maternal and paternal depressive symptomatology, specifically how symptoms in 1 partner relate to subsequent symptom level changes in the other partner throughout the perinatal period. Further, we aim to identify parents who are particularly vulnerable to the development of disruptive processes of negative mood states. Read More

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http://dx.doi.org/10.1037/abn0000429DOI Listing

Psychometrics of the Violence Nonlinear Dynamics Scale.

Prim Care Companion CNS Disord 2019 Apr 4;21(2). Epub 2019 Apr 4.

Family and Community Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.

Objective: The trajectory of daily partner violence generally demonstrates nonlinear dynamics, and this nonlinearity is important to patient outcomes, as it is sometimes a stronger predictor of outcomes than violence frequency or severity. However, measurement of such dynamics is difficult, requiring complete time series data of sufficient length to yield stable measures. The purpose of this study was to develop a pencil-and-paper instrument to estimate violence nonlinearity and assess its psychometrics. Read More

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http://www.psychiatrist.com/PCC/article/Pages/2019/v21n02/18
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http://dx.doi.org/10.4088/PCC.18m02404DOI Listing
April 2019
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