8,311 results match your criteria Journal of Controlled Release[Journal]


Anti-atherogenic effects of CD36-targeted epigallocatechin gallate-loaded nanoparticles.

J Control Release 2019 Apr 15. Epub 2019 Apr 15.

Department of Nutritional Sciences, Texas Tech University, Lubbock, TX 79409, USA. Electronic address:

Intimal macrophages play a critical role in atherosclerotic lesion initiation and progression by taking up oxidized low-density lipoprotein (oxLDL) and promoting inflammatory process. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine (KOdiA-PC), a major type of oxidized phosphatidylcholines (PC) found on oxLDL, has a high binding affinity to the macrophage scavenger receptor CD36 and participates in CD36-mediated recognition and uptake of oxLDL by intimal macrophages. We successfully synthesized epigallocatechin gallate (EGCG)-loaded nanoparticles (Enano), which were composed of EGCG, PC, (+) alpha-tocopherol acetate, and surfactant. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193021
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http://dx.doi.org/10.1016/j.jconrel.2019.04.018DOI Listing
April 2019
1 Read

MPL nano-liposomal vaccine containing P5 HER2/neu-derived peptide pulsed PADRE as an effective vaccine in a mice TUBO model of breast cancer.

J Control Release 2019 Apr 15. Epub 2019 Apr 15.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Liposomal peptide-based vaccines can potentially suppress cancer cells proliferation in the host. To enhance the effectiveness of vaccination against cancer, additional strategies should also be employed. One strategy to promote peptide-based vaccine efficacy and induce powerful immune responses, is simultaneous activation of CD4 and CD8 T cells. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.019DOI Listing

Imitation of nature: Bionic design in the study of particle adjuvants.

Authors:
Jie Wu Guanghui Ma

J Control Release 2019 Apr 13. Epub 2019 Apr 13.

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; PLA Key Laboratory of Biopharmaceutical Production and Formulation Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China; Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing 211816, PR China. Electronic address:

Vaccine adjuvants play an increasingly important role in the development of modern vaccines. Among of them, particle adjuvants have received wide attention due to their unique properties. In order to develop effective particle adjuvants, mimicking natural pathogens is one of the important strategies. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.004DOI Listing

Lipid nanoparticles for delivery of messenger RNA to the back of the eye.

J Control Release 2019 Apr 12. Epub 2019 Apr 12.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, Oregon, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, USA. Electronic address:

Retinal gene therapy has had unprecedented success in generating treatments that can halt vision loss. However, immunogenic response and long-term toxicity with the use of viral vectors remain a concern. Non-viral vectors are relatively non-immunogenic, scalable platforms that have limited success with DNA delivery to the eye. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.015DOI Listing

Editorial.

Authors:

J Control Release 2019 Apr 12. Epub 2019 Apr 12.

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http://dx.doi.org/10.1016/j.jconrel.2019.04.017DOI Listing

In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration.

J Control Release 2019 Apr 11. Epub 2019 Apr 11.

INSERM, Centre d'Etude des Pathologies Respiratoires, U1100, F-37032 Tours, France; Université de Tours, F-37032 Tours, France. Electronic address:

Due to growing antibiotic resistance, pneumonia caused by Pseudomonas aeruginosa is a major threat to human health and is driving the development of novel anti-infectious agents. Preventively or curatively administered pathogen-specific therapeutic antibodies (Abs) have several advantages, including a low level of toxicity and a unique pharmacological profile. At present, most Abs against respiratory infections are administered parenterally; this may not be optimal for therapeutics that have to reach the lungs to be effective. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.005DOI Listing

Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physico-chemical characterization and in vitro evaluation in 2D/3D in vitro models.

J Control Release 2019 Apr 11. Epub 2019 Apr 11.

Functional Polymer Materials, Department of Chemistry and Pharmacy and Bavarian Polymer Institute, Würzburg University, Röntgenring 11, 97070 Würzburg, Germany. Electronic address:

Curcumin (CUR) is a natural extract from the plant Curcuma longa and part of turmeric, a spice and herbal remedy in traditional medicine. Thousands of papers claim a plethora of health benefits by CUR, but a growing number of reports and contributions caution that many experimental data may be artifacts or outright deny any suitability of CUR due to its problematic physicochemical properties. Two major issues often encountered with CUR are its extraordinarily low solubility in water and its limited chemical stability. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.014DOI Listing

Prevention of paclitaxel-induced neuropathy by formulation approach.

J Control Release 2019 Apr 11. Epub 2019 Apr 11.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States of America. Electronic address:

Chemotherapy-induced peripheral neuropathy (CIPN) is a major adverse effect of paclitaxel. Several liposome-based products have been approved and demonstrated superior efficacy and safety profiles for other drugs. The first objective of this work was to evaluate the effect of liposome formulation of paclitaxel (L-PTX) on neurotoxicity in-vitro and in-vivo in comparison to the standard Taxol® formulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193021
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http://dx.doi.org/10.1016/j.jconrel.2019.04.013DOI Listing
April 2019
1 Read

Thermoreversible mucoadhesive polymer-drug dispersion for sustained local delivery of budesonide to treat inflammatory disorders of the GI tract.

J Control Release 2019 Apr 11;303:12-23. Epub 2019 Apr 11.

Laboratório de Nanotecnologia Farmacêutica e Sistemas de Liberação de Fármacos, FarmaTec, Faculdade de Farmácia, Universidade Federal de Goiás - UFG, Goiânia, Goiás, Brazil. Electronic address:

Mucoadhesive drug formulations have been studied and used as alternatives to conventional formulations in order to achieve prolonged retention at the intended site. In addition to providing a controlled drug release, several drugs and disease conditions might benefit from mucoadhesive formulations, contributing to better therapeutic outcomes. Here, we describe the development and the in vitro/in vivo characterization of a mucoadhesive in situ gellifying formulation using PF127, a thermo reversible polymer, entrapping budesonide (BUD), a potent corticosteroid used for the treatment of a wide range of inflammatory diseases, including those affecting mucosas, such as in the GI tract. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.011DOI Listing

Exocytosis - a putative road-block in nanoparticle and nanocomplex mediated gene delivery.

J Control Release 2019 Apr 10. Epub 2019 Apr 10.

CSIR - Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India. Electronic address:

Gene and drug delivery mediated by nanostructures has seen tremendous growth over the last decade. However, the efficiency of these delivery approaches needs to be improved for better effects. Amongst various factors, cellular retention is expected to play a critical role. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.012DOI Listing

Retraction notice to "Polyethylenimine Nanoparticles as Efficient Transfecting Agents for Mammalian Cells" [Journal of Controlled Release 110/2 (2005) 457-468].

J Control Release 2019 04;300:200

Nucleic Acids Research Laboratory and Division of Allergy and Infectious Diseases, Institute of Genomics and Integrative Biology, Mall Road, Delhi University Campus, Delhi - 110 007, India.

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193011
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http://dx.doi.org/10.1016/j.jconrel.2019.02.029DOI Listing
April 2019
3 Reads

Collective progress in drug delivery.

Authors:
Kinam Park

J Control Release 2019 Apr;300:197-199

Purdue University, Biomedical Engineering and Pharmaceutics, West Lafayette, IN 47907, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.03.023DOI Listing

Combining activatable nanodelivery with immunotherapy in a murine breast cancer model.

J Control Release 2019 Apr 9. Epub 2019 Apr 9.

Stanford University, Department of Radiology, 3165 Porter Drive, Palo Alto, CA 94304, USA. Electronic address:

A successful chemotherapy-immunotherapy solid-tumor protocol should accomplish the following goals: debulk large tumors, release tumor antigen for cross-presentation and cross-priming, release cancer-suppressive cytokines and enhance anti-tumor immune cell populations. Thermally-activated drug delivery particles have the potential to synergize with immunotherapeutics to accomplish these goals; activation can release chemotherapy within bulky solid tumors and can enhance response when combined with immunotherapy. We set out to determine whether a single protocol, combining locally-activated chemotherapy and agonist immunotherapy, could accomplish these goals and yield a potentially translational therapy. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.008DOI Listing
April 2019
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Widespread gene transfer to malignant gliomas with In vitro-to-In vivo correlation.

J Control Release 2019 Apr 9;303:1-11. Epub 2019 Apr 9.

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States of America; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, United States of America; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, United States of America. Electronic address:

Gene therapy of malignant gliomas has shown a lack of clinical success to date due in part to inability of conventional gene vectors to achieve widespread gene transfer throughout highly disseminated tumor areas within the brain. Here, we demonstrate that newly engineered polymer-based DNA-loaded nanoparticles (DNA-NP) possessing small particle diameters (~50 nm) and non-adhesive surface polyethylene glycol (PEG) coatings efficiently penetrate brain tumor tissue as well as healthy brain parenchyma. Specifically, this brain-penetrating nanoparticle (BPN), following intracranial administration via convection enhanced delivery (CED), provides widespread transgene expression in heathy rodent striatum and an aggressive brain tumor tissue established orthotopically in rats. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.010DOI Listing

Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55.

J Control Release 2019 Apr 8;302:181-189. Epub 2019 Apr 8.

Translational Bio-Nanosciences Laboratory, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:

Complement activation plays an important role in pharmacokinetic and performance of intravenously administered nanomedicines. Significant efforts have been directed toward engineering of nanosurfaces with low complement activation, but due to promiscuity of complement factors and redundancy of pathways, it is still a major challenge. Cell membrane-anchored Decay Accelerating Factor (DAF, a. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.009DOI Listing

Bioink-guided spatio-temporal gene delivery for tissue engineering.

Authors:
Kinam Park

J Control Release 2019 Apr 8;301:190. Epub 2019 Apr 8.

Purdue University, Biomedical Engineering and Pharmaceutics, West Lafayette, IN 47907, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.04.007DOI Listing

Expanding therapeutic utility of carfilzomib for breast cancer therapy by novel albumin-coated nanocrystal formulation.

J Control Release 2019 Apr 4;302:148-159. Epub 2019 Apr 4.

College of Pharmacy and Research, Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea. Electronic address:

Carfilzomib (CFZ) is the second-in-class proteasome inhibitor with much improved efficacy and safety profiles over bortezomib in multiple myeloma patients. In expanding the utility of CFZ to solid cancer therapy, the poor aqueous solubility and in vivo instability of CFZ are considered major drawbacks. We investigated whether a nanocrystal (NC) formulation can address these issues and enhance anticancer efficacy of CFZ against breast cancer. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.006DOI Listing
April 2019
1 Read

Multifunctional hyaluronate - Nanoparticle hybrid systems for diagnostic, therapeutic and theranostic applications.

J Control Release 2019 Apr 4. Epub 2019 Apr 4.

PHI Biomed Co., 175 Yeoksam-ro, Gangnam-gu, Seoul 06247, South Korea; Department of Materials Science and Engineering, POSTECH, 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, South Korea. Electronic address:

Diagnostic and therapeutic nanoparticles have been actively investigated for the last few decades as new platforms for biomedical applications. Despite their great versatility and potency, nanoparticles have generally required further modification with biocompatible materials such as biopolymers and synthetic polymers for in vivo administration to improve their biological functions, stability, and biocompatibility. Among a variety of natural and synthetic biomaterials, hyaluronate (HA) has been considered a promising biomolecule with which to construct nanohybrid systems, as it can enable long-term and efficient delivery of nanoparticles to target sites as well as physiological stabilization of nanoparticles by forming hydrophilic shells. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.003DOI Listing

Intra-articular delivery of synovium-resident mesenchymal stem cells via BMP-7-loaded fibrous PLGA scaffolds for cartilage repair.

J Control Release 2019 Apr 4;302:169-180. Epub 2019 Apr 4.

Paik Institute for Clinical Research, Inje University College of Medicine, 75, Bokji-ro, Busanjin-gu, Busan 47392, Republic of Korea. Electronic address:

Delivery of synovium-resident mesenchymal stem cells (synMSCs) to cartilage defect site might provide a novel therapeutic modality for treatment of articular cartilage diseases. However, low isolation efficiency of synMSCs limits their therapeutic application. Niche-preserving non-enzymatic isolation of synMSCs was firstly attempted by employing micro-organ culture system based on recapitulating tissue-specific homeostasis ex vivo. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.002DOI Listing
April 2019
1 Read
7.705 Impact Factor

Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging.

J Control Release 2019 Apr 3;302:140-147. Epub 2019 Apr 3.

King's College London, Institute of Pharmaceutical Science, London SE1 9NH, UK.

This study aimed to characterise three nasal drug delivery devices to evaluate their propensity to deliver human insulin solutions to the nasal cavity for redistribution to the central nervous system. Brain delivery was evaluated using functional magnetic resonance imaging to measure regional cerebral blood flow. Intranasal insulin administration has been hypothesised to exploit nose-to-brain pathways and deliver drug directly to the brain tissue whilst limiting systemic exposure. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.032DOI Listing

Amelioration of the nigrostriatal pathway facilitated by ultrasound-mediated neurotrophic delivery in early Parkinson's disease.

J Control Release 2019 Apr 3. Epub 2019 Apr 3.

Departments of Biomedical Engineering, Columbia University, New York, NY 10032, USA; Departments of Radiology, Columbia University, New York, NY 10032, USA; the Columbia Translational Neuroscience Initiative, Columbia University, New York, NY 10032, USA. Electronic address:

The blood-brain barrier (BBB) prevents most drugs from gaining access to the brain parenchyma, which is a recognized impediment to the treatment of neurodegenerative disorders like Parkinson's disease (PD). Focused ultrasound (FUS), in conjunction with systemically administered microbubbles, opens the BBB locally, reversibly and non-invasively. Herein, we show that neither FUS applied over both the striatum and the ventral midbrain, without neurotrophic factors, nor intravenous administration of neurotrophic factors (either through protein or gene delivery) without FUS, ameliorates the damage to the nigrostriatal dopaminergic pathway in the sub-acute MPTP mouse model of early-stage PD. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.030DOI Listing
April 2019
1 Read
7.705 Impact Factor

A review of magnet systems for targeted drug delivery.

J Control Release 2019 Apr 1;302:90-104. Epub 2019 Apr 1.

Institute for Special Environmental Biophysics, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, PR China; Shenzhen Research Institute of Northwestern Polytechnical University, Shenzhen 518057, Guangzhou, PR China. Electronic address:

Magnetic drug targeting is a method by which magnetic drug carriers in the body are manipulated by external magnetic fields to reach the target area. This method is potentially promising in applications for treatment of diseases like cancers, nervous system diseases, sudden sensorineural hearing loss, and so on, due to the advantages in that it can improve efficacy, reduce drug dosage and side effects. Therefore, it has received extensive attention in recent years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193019
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http://dx.doi.org/10.1016/j.jconrel.2019.03.031DOI Listing
April 2019
4 Reads
7.705 Impact Factor

Self-facilitated ROS-responsive nanoassembly of heterotypic dimer for synergistic chemo-photodynamic therapy.

J Control Release 2019 Apr 1;302:79-89. Epub 2019 Apr 1.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China. Electronic address:

There is an urgent need to develop efficient combination drug delivery approaches to address the low efficiency of clinical cancer monotherapy. However, how to achieve high-efficient synchronous co-delivery and synergistic therapy remains a big challenge. Herein, we report a self-facilitated nanoassembly of a heterotypic chemo-photodynamic dimer for multimodal cancer therapy. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.001DOI Listing
April 2019
7.705 Impact Factor

A low inflammatory, Langerhans cell-targeted microprojection patch to deliver ovalbumin to the epidermis of mouse skin.

J Control Release 2019 Mar 30. Epub 2019 Mar 30.

The Delivery of Drugs and Genes Group (D(2)G(2)), Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, QL 4072, Australia. Electronic address:

In a low inflammatory skin environment, Langerhans cells (LCs) - but not dermal dendritic cells (dDCs) - contribute to the pivotal process of tolerance induction. Thus LCs are a target for specific-tolerance therapies. LCs reside just below the stratum corneum, within the skin's viable epidermis. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.027DOI Listing
March 2019
8 Reads

Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary arterial hypertension.

J Control Release 2019 Mar 30;302:126-139. Epub 2019 Mar 30.

Department of Pharmaceutical Sciences, St. John Fisher College, Rochester, NY, USA. Electronic address:

Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for sustained pulmonary delivery of sildenafil citrate. Spray dried hydrogel microparticles containing biodegradable sodium carboxymethyl cellulose, sodium alginate, and sodium hyaluronate polymers at variable concentrations were prepared. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.029DOI Listing
March 2019
2 Reads

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.

J Control Release 2019 Mar 30;302:116-125. Epub 2019 Mar 30.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01604, USA. Electronic address:

Lipid-conjugated small-interfering RNAs (siRNAs) exhibit accumulation and gene silencing in extrahepatic tissues, providing an opportunity to expand therapeutic siRNA utility beyond the liver. Chemically engineering lipids may further improve siRNA delivery and efficacy, but the relationship between lipid structure/configuration and siRNA pharmacodynamics is unclear. Here, we synthesized a panel of mono-, di-, and tri-meric fatty acid-conjugated siRNAs to systematically evaluate the impact of fatty acid structure and valency on siRNA clearance, distribution, and efficacy. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.028DOI Listing
March 2019
2 Reads

Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques.

J Control Release 2019 Mar 29;302:105-115. Epub 2019 Mar 29.

Department of Molecular Imaging, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan; Laboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan. Electronic address:

The development of atherosclerotic plaques is a critical step that can result in an arterial embolism. Therefore, detection of these vulnerable plaques is of clinical significance for the diagnosis of atherosclerosis. However, there are few imaging systems able to detect such plaques easily. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.025DOI Listing
March 2019
1 Read

Evaluating accessibility of intravenously administered nanoparticles at the lesion site in rat and pig contusion models of spinal cord injury.

J Control Release 2019 Mar 28;302:160-168. Epub 2019 Mar 28.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address:

In spinal cord injury (SCI), timely therapeutic intervention is critical to inhibit the post-injury rapidly progressing degeneration of spinal cord. Towards that objective, we determined the accessibility of intravenously administered biodegradable nanoparticles (NPs) as a drug delivery system to the lesion site in rat and pig contusion models of SCI. Poly (d,l-lactide co-glycolide, PLGA)-based NPs loaded with a near-infrared dye as a marker for NPs were used. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.026DOI Listing

Modulation of pericytes by a fusion protein comprising of a PDGFRβ-antagonistic affibody and TNFα induces tumor vessel normalization and improves chemotherapy.

J Control Release 2019 Mar 28;302:63-78. Epub 2019 Mar 28.

Key Lab of Transplant Engineering and Immunology, MOH, Regenerative Medical Research Center, China. Electronic address:

The delivery of anticancer drugs is hampered by tumor vessels with abnormal structure and function, which requires that vessel normalization be mediated by pharmaceutics. The current strategies for vessel normalization focus on direct modulation of endothelial cells (ECs), which frequently affect vessels in normal tissues. Modulating EC-supporting cells, such as pericytes (PCs), is a new direction. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.018DOI Listing
March 2019
1 Read

Corrigendum to 'Thermosensitive nanocomposite gel for intra-tumoral two-photon photodynamic therapy' [Journal of Controlled Release 298 (2019) 99-109].

J Control Release 2019 Mar 28;302. Epub 2019 Mar 28.

Department of Chemistry, Anhui University, Hefei, PR China; Department of Chemistry, University College London, UK; Department of Chemical Engineering, University College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.03.024DOI Listing
March 2019
7.705 Impact Factor

A pharmaceutical answer to nonadherence: Once weekly oral memantine for Alzheimer's disease.

J Control Release 2019 Mar 27. Epub 2019 Mar 27.

Lyndra, Inc., 65 Grove St, Watertown, MA 02471, United States of America; Brigham and Women's Division of Cardiovascular Medicine, 75 Francis St, Boston, MA 02115, United States of America. Electronic address:

Adherence to medication regimens is a major barrier to effective treatment in many disease areas, notably in dementia which causes cognitive impairment that reduces patients' awareness of non-adherence and their ability to manage medication. The development of oral dosage forms that can be infrequently dosed, and therefore improve adherence rate and facilitate direct observed therapy, has been a goal for decades. We describe the first demonstration of an oral formulation that achieves >7-day gastric retention and sustained pharmacokinetics in the challenging dog model. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.022DOI Listing

Fluorous-phase iron oxide nanoparticles as enhancers of acoustic droplet vaporization of perfluorocarbons with supra-physiologic boiling point.

J Control Release 2019 Mar 27;302:54-62. Epub 2019 Mar 27.

Department of Radiology, Translational Research in Ultrasound Theranostics (TRUST) Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

Perfluorocarbon emulsion nanodroplets containing iron oxide nanoparticles (IONPs) within their inner perfluorohexane (PFH) core were prepared to investigate potential use as an acoustically activatable ultrasound contrast agent, with the hypothesis that incorporation of IONPs into the fluorous phase of a liquid perfluorocarbon emulsion would potentiate acoustic vaporization. IONPs with an oleic acid (OA) hydrophobic coating were synthesized through chemical co-precipitation. To suspend IONP in PFH, OA was exchanged with perfluorononanoic acid (PFNA) via ligand exchange to yield fluorophilic PFNA-coated IONPs (PFNA-IONPs). Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.013DOI Listing

Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles.

J Control Release 2019 Mar 26;302:42-53. Epub 2019 Mar 26.

Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.

Synchronized bio-distribution of combination therapies has several merits such as synergistic effects and reduced side-effects. Co-delivery of a protein and small molecule drug using a single nanocarrier is challenging because they possess totally different characteristics. Herein, we report the development of sophisticated nanoparticles composed of lipids, calcium carbonate and RGD peptide ligands for the co-delivery of a protein and small molecule drug combination via a simple preparation method. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.021DOI Listing
March 2019
1 Read

Electrospun polymer micro/nanofibers as pharmaceutical repositories for healthcare.

J Control Release 2019 Mar 26;302:19-41. Epub 2019 Mar 26.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.

Electrospun polymer micro/nanofibers have been widely explored as platforms for controlled delivery of therapeutic agents. Electrospun fibers are featured by large surface area, high porosity, and tunable morphology, which can be manipulated to fabricate micro/nanofibers with appropriate physicochemical properties, degradation kinetics, and drug release profiles. Many therapeutic agents can be separately or simultaneously loaded by electrospun fibers in the application of cancer therapy, adhesion prevention, wound repair, and regeneration of bone and nerve. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.020DOI Listing
March 2019
7.705 Impact Factor

Hierarchical tumor acidity-responsive self-assembled magnetic nanotheranostics for bimodal bioimaging and photodynamic therapy.

J Control Release 2019 Mar 21;301:157-165. Epub 2019 Mar 21.

Theranostic Macromolecules Research Center and School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Republic of Korea. Electronic address:

Nanosized self-assemblies built from inorganic nanoparticles and polymer ligands have the potential to generate personalized theranostics systems for diagnostic imaging and cancer therapy. However, most of the theranostics systems suffer from poor targeting activity, insensitive diagnosis and drug leakage, leading to poor treatment results. In this study, a hierarchical tumor acidity-responsive magnetic nanobomb (termed HTAMN) was developed for photodynamic therapy and diagnostic imaging. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.019DOI Listing

Ultrasound-activated microbubbles as a novel intracellular drug delivery system for urinary tract infection.

J Control Release 2019 Mar 20;301:166-175. Epub 2019 Mar 20.

Department of Renal Medicine, Division of Medicine, University College, London, UK. Electronic address:

The development of new modalities for high-efficiency intracellular drug delivery is a priority for a number of disease areas. One such area is urinary tract infection (UTI), which is one of the most common infectious diseases globally and which imposes an immense economic and healthcare burden. Common uropathogenic bacteria have been shown to invade the urothelial wall during acute UTI, forming latent intracellular reservoirs that can evade antimicrobials and the immune response. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.017DOI Listing

cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo.

J Control Release 2019 Mar 18;301:110-118. Epub 2019 Mar 18.

Biomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China. Electronic address:

The clinical success of nanomedicines demands on the development of simple biodegradable nanocarriers that can efficiently and stably encapsulate chemotherapeutics while quickly release the payloads into target cancer cells. Herein, we report that cRGD-decorated biodegradable polytyrosine nanoparticles (cRGD-PTN) boost encapsulation and targeted delivery of doxorubicin (DOX) to colorectal cancer in vivo. The co-assembly of poly(ethylene glycol)-poly(L-tyrosine) (PEG-PTyr) and cRGD-functionalized PEG-PTyr (mol/mol, 80/20) yielded small-sized cRGD-PTN of 70 nm. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.005DOI Listing

Pharmacokinetic studies for cochlear drug delivery.

Authors:
Kinam Park

J Control Release 2019 Apr;299:165

Purdue University, Biomedical Engineering and Pharmaceutics, West Lafayette, IN 47907, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.03.007DOI Listing

Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse model of type II diabetes.

J Control Release 2019 Mar 17;301:119-128. Epub 2019 Mar 17.

School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Research Center for Functional Biomaterials Engineering and Technology, Sun Yat-sen University, Guangzhou 510275, China; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

Exendin-4 has been clinically adopted as an effective drug for treating type 2 diabetes (T2D), but its short circulation half-life in the blood requires two injections per day to maintain effective glycemic control. This significantly limits its clinical application. In this study, we developed a tannic acid/exendin-4/Fe ternary nanoparticle system to provide sustained release of exendin-4 in vivo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193016
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http://dx.doi.org/10.1016/j.jconrel.2019.03.014DOI Listing
March 2019
4 Reads

Threatening cancer with nanoparticle aided combination oncotherapy.

J Control Release 2019 Mar 16;301:76-109. Epub 2019 Mar 16.

Department of Pharmaceutics, Institute of Pharmacy, Nirma University, SG Highway, Chharodi, Ahmedabad 382481, Gujarat, India. Electronic address:

Employing combination therapy has become obligatory in cancer cases exhibiting high tumor load, chemoresistant tumor population, and advanced disease stages. Realization of this fact has now led many of the combination oncotherapies to become an integral part of anticancer regimens. Combination oncotherapy may encompass a combination of anticancer agents belonging to a similar therapeutic category or that of different therapeutic categories (e. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.015DOI Listing

Microfragmented human fat tissue is a natural scaffold for drug delivery: Potential application in cancer chemotherapy.

J Control Release 2019 Mar 16;302:2-18. Epub 2019 Mar 16.

CRC StaMeTec, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Localization of chemotherapy at the tumor site can improve therapeutic efficacy and reduce systemic toxicity. In previous studies we have shown that mesenchymal stromal cells (MSCs) isolated from bone marrow or adipose tissue can be loaded with the anti-cancer drug Paclitaxel (PTX) and kill cancer cells when localized nearby. We here investigated the capacity of human micro-fragmented adipose tissue (MFAT), used as a natural scaffold of MSCs, to deliver PTX with the idea to improve local drug concentration and to prolong the therapeutic activity. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.016DOI Listing
March 2019
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Oligodepsipeptide (nano)carriers: Computational design and analysis of enhanced drug loading.

J Control Release 2019 Mar 15;301:146-156. Epub 2019 Mar 15.

Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Teltow, Germany; Institute of Chemistry, University of Potsdam, Potsdam, Germany. Electronic address:

High drug loads of nanoparticles are essential to efficiently provide a desired dosage in the required timeframe, however, these conditions may not be reached with so far established degradable matrices. Our conceptual approach for increasing the drug load is based on strengthening the affinity between drug and matrix in combination with stabilizing drug-matrix-hybrids through strong intermolecular matrix interactions. Here, a method for designing such complex drug-matrix hybrids is introduced employing computational methods (molecular dynamics and docking) as well as experimental studies (affinity, drug loading and distribution, drug release from films and nanoparticles). Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.004DOI Listing

Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis.

J Control Release 2019 Mar 14;301:129-139. Epub 2019 Mar 14.

Department of Engineering, Aarhus University, DK-8000 Aarhus C, Denmark; Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark. Electronic address:

In bone tissue engineering, electrospun fibrous scaffolds can provide excellent mechanical support, extracellular matrix mimicking components, such as 3D spacial fibrous environment for cell growth and controlled release of signaling molecules for osteogenesis. Here, a facile strategy comprising the incorporation of an osteogenic inductive peptide H1, derived from the cysteine knot (CT) domain of connective tissue growth factor (CTGF), in the core of Silk Fibroin (SF) was developed for osteogenic induction, synergistically with co-delivering hydroxyapatite (HA) from the shell of poly(l-lactic acid-co-ε-caprolactone) (PLCL). The core-shell nanofibrous structure was confirmed by transmission electron microscopy (TEM). Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.037DOI Listing

Combining mathematical modelling with in vitro experiments to predict in vivo drug-eluting stent performance.

J Control Release 2019 Mar 13. Epub 2019 Mar 13.

Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK.

In this study, we developed a predictive model of in vivo stent based drug release and distribution that is capable of providing useful insights into performance. In a combined mathematical modelling and experimental approach, we created two novel sirolimus-eluting stent coatings with quite distinct doses and release kinetics. Using readily measurable in vitro data, we then generated parameterised mathematical models of drug release. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.012DOI Listing

Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model.

J Control Release 2019 Mar 13;301:62-75. Epub 2019 Mar 13.

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Spain; Institute of Nanoscience and Nanotechnology (IN2UB), Barcelona, Spain. Electronic address:

Epigallocatechin-3-gallate (EGCG) is a candidate for treatment of Alzheimer's disease (AD) but its inherent instability limits bioavailability and effectiveness. We found that EGCG displayed increased stability when formulated as dual-drug loaded PEGylated PLGA nanoparticles (EGCG/AA NPs). Oral administration of EGCG/AA NPs in mice resulted in EGCG accumulation in all major organs, including the brain. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.010DOI Listing
March 2019
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Pharmaceutical jewelry: Earring patch for transdermal delivery of contraceptive hormone.

J Control Release 2019 Mar 12;301:140-145. Epub 2019 Mar 12.

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address:

Lack of adherence to medication dosing schedules is a significant cause of morbidity and mortality with large associated financial costs. This is especially true for contraceptive hormones, which provide almost perfect prevention of pregnancy when used correctly, but have significant failure rates in typical use, due largely to poor adherence. To increase medication acceptability and adherence, we introduce pharmaceutical jewelry, in which a transdermal patch is incorporated into jewelry worn on skin. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.011DOI Listing
March 2019
1 Read

Sustained release silk fibroin discs: Antibody and protein delivery for HIV prevention.

J Control Release 2019 Mar 12;301:1-12. Epub 2019 Mar 12.

Department of Biomedical Engineering, Tufts University, Medford, MA, USA. Electronic address:

With almost 2 million new HIV infections worldwide each year, the prevention of HIV infection is critical for stopping the pandemic. The only approved form of pre-exposure prophylaxis is a costly daily pill, and it is recognized that several options will be needed to provide protection to the various affected communities around the world. In particular, many at-risk people would benefit from a prevention method that is simple to use and does not require medical intervention or a strict daily regimen. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.001DOI Listing
March 2019
6 Reads

Tumor-specific macrophage targeting through recognition of retinoid X receptor beta.

J Control Release 2019 Mar 11;301:42-53. Epub 2019 Mar 11.

Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

Macrophages play important and diverse roles during cancer progression. However, cancer therapies based on macrophage modulation are lacking in tools that can recognize and deliver therapeutic payloads to macrophages in a tumor-specific manner. As a result, treatments tend to interfere with normal macrophage functions in healthy organs. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.009DOI Listing
March 2019
4 Reads

Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain.

J Control Release 2019 Mar 11;301:54-61. Epub 2019 Mar 11.

Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

New advances in intra-arterial (IA) catheters offer clinically proven local interventions in the brain. Here we tested the effect of combining local IA delivery and vascular immunotargeting. Microinjection of tumor necrosis factor alpha (TNFα) in the brain parenchyma causes cerebral overexpression of Inter-Cellular Adhesion Molecule-1 (ICAM-1) in mice. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.03.008DOI Listing

The cancer survivor's journey.

Authors:
Lora Kelly

J Control Release 2019 Mar 8. Epub 2019 Mar 8.

330 Hickory Road, Carlisle, PA 17015, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.02.013DOI Listing