17,552 results match your criteria Journal of Comparative Neurology[Journal]


Cholecystokinin Immunoreactive Neurons in the Basolateral Amygdala of the Rhesus Monkey (Macaca mulatta).

J Comp Neurol 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia.

Several distinct subpopulations of interneurons (INs) in the amygdalar basolateral nuclear complex (BNC) of the rat can be recognized on the basis of their expression of calcium-binding proteins and neuropeptides, including parvalbumin (PV), somatostatin (SOM), calretinin (CR), and cholecystokinin (CCK). In the rat BNC CCK is expressed in two separate IN subpopulations, termed large (CCK ) and small (CCK ). These subpopulations exhibit distinct connections indicative of discrete functional roles in the circuitry of the BNC. Read More

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http://dx.doi.org/10.1002/cne.24700DOI Listing

Central connections of the trigeminal motor command system in the weakly electric Elephantnose fish (Gnathonemus petersii).

J Comp Neurol 2019 Apr 13. Epub 2019 Apr 13.

Department of Neuroethology/Sensory Ecology, Institute for Zoology, University of Bonn, Bonn, Germany.

The highly mobile chin appendage of Gnathonemus petersii, the Schnauzenorgan, is used to actively probe the environment and is known to be a fovea of the electrosensory system. It receives an important innervation from both the trigeminal sensory and motor systems. However, little is known about the pre-motor control pathways that coordinate the movements of the Schnauzenorgan, or about central pathways originating from the trigeminal motor nucleus. Read More

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http://dx.doi.org/10.1002/cne.24701DOI Listing

Pretectal projections to the oculomotor cerebellum in hummingbirds (Calypte anna), zebra finches (Taeniopygia guttata), and pigeons (Columba livia).

J Comp Neurol 2019 Apr 5. Epub 2019 Apr 5.

Neuroscience and Mental Health Institute and Department of Psychology, University of Alberta, Edmonton, Alberta, Canada.

In birds, optic flow is processed by a retinal-recipient nucleus in the pretectum, the nucleus lentiformis mesencephali (LM), which then projects to the cerebellum, a key site for sensorimotor integration. Previous studies have shown that the LM is hypertrophied in hummingbirds, and that LM cell response properties differ between hummingbirds and other birds. Given these differences in anatomy and physiology, we ask here if there are also species differences in the connectivity of the LM. Read More

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http://dx.doi.org/10.1002/cne.24697DOI Listing

Afferent neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats.

J Comp Neurol 2019 Apr 5. Epub 2019 Apr 5.

Department of Endocrinology and Metabolism & Laboratory of Endocrinology, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

The hypothalamic neuropeptide Y (NPY) circuitry is a key regulator of feeding behavior. NPY also acts in the mesolimbic dopaminergic circuitry, where it can increase motivational aspects of feeding behavior through effects on dopamine output in the nucleus accumbens (NAc) and on neurotransmission in the ventral tegmental area (VTA). Endogenous NPY in the NAc originates from local interneurons and afferent projections from the hypothalamic arcuate nucleus (Arc). Read More

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http://dx.doi.org/10.1002/cne.24698DOI Listing
April 2019
1 Read

The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration.

J Comp Neurol 2019 Apr 4. Epub 2019 Apr 4.

School of Medicine, University of St Andrews, St Andrews, UK.

Dyslexia is a common neurodevelopmental disorder caused by a significant genetic component. The KIAA0319 gene is one of the most robust dyslexia susceptibility factors but its function remains poorly understood. Initial RNA-interference studies in rats suggested a role in neuronal migration whereas subsequent work with double knock-out mouse models for both Kiaa0319 and its paralogue Kiaa0319-like reported effects in the auditory system but not in neuronal migration. Read More

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http://dx.doi.org/10.1002/cne.24696DOI Listing

Domain-specific distribution of gap junctions defines cellular coupling to establish a vascular relay in the retina.

J Comp Neurol 2019 Apr 5. Epub 2019 Apr 5.

Burke Neurological Institute, Department of Ophthalmology, Weill Cornell Medicine, White Plains, New York.

In the retina, diverse functions of neuronal gap junctions (GJs) have been established. However, the distribution and function of vascular GJs are less clear. Here in the mouse retina whole mounts, we combined structural immunohistochemical analysis and a functional assessment of cellular coupling with a GJ-permeable tracer Neurobiotin to determine distribution patterns of three major vascular connexins. Read More

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http://dx.doi.org/10.1002/cne.24699DOI Listing

Characterization of the relaxin family peptide receptor 3 system in the mouse bed nucleus of the stria terminalis.

J Comp Neurol 2019 Apr 4. Epub 2019 Apr 4.

Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.

The bed nucleus of the stria terminalis (BNST) is a critical node involved in stress and reward-related behaviors. Relaxin family peptide receptor 3 (RXFP3) signaling in the BNST has been implicated in stress-induced alcohol seeking behavior. However, the neurochemical phenotype and connectivity of BNST RXFP3-expressing (RXFP3+) cells have yet to be elucidated. Read More

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http://dx.doi.org/10.1002/cne.24695DOI Listing

Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits.

J Comp Neurol 2019 Apr 3. Epub 2019 Apr 3.

Departmento de Fisiología. CIMUS, Universidad de Santiago de Compostela, 15782. Santiago de Compostela, Spain.

The cold- and menthol-activated ion channel TRPM8 is the principal detector of environmental cold in mammalian sensory nerve endings. Although it is mainly expressed in a subpopulation of peripheral sensory neurons, it has also been identified in non-neuronal tissues. Here we show, by in situ hybridization and by the analysis of transgenic reporter expression in two different reporter mouse strains, that TRPM8 is also expressed in the central nervous system. Read More

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http://dx.doi.org/10.1002/cne.24694DOI Listing
April 2019
2 Reads

The sensory thalamus and visual midbrain in mouse lemurs.

J Comp Neurol 2019 Mar 30. Epub 2019 Mar 30.

Department of Psychology, Vanderbilt University, Nashville, Tennessee.

Mouse lemurs are the smallest of extant primates and are thought to resemble early primates in many ways. We provide histological descriptions of the major sensory nuclei of the dorsal thalamus and the superior colliculus (SC) of mouse lemurs (Microcebus murinus). The dorsal lateral geniculate nucleus has the six layers typical of strepsirrhine primates, with matching pairs of magnocellular, parvocellular, and koniocellular layers, one of each pair for each eye. Read More

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http://dx.doi.org/10.1002/cne.24693DOI Listing

Developmental organization of central neurons in the adult Drosophila ventral nervous system.

J Comp Neurol 2019 Mar 28. Epub 2019 Mar 28.

Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia.

We have used MARCM to reveal the adult morphology of the post embryonically produced neurons in the thoracic neuromeres of the Drosophila VNS. The work builds on previous studies of the origins of the adult VNS neurons to describe the clonal organization of the adult VNS. We present data for 58 of 66 postembryonic thoracic lineages, excluding the motor neuron producing lineages (15 and 24) which have been described elsewhere. Read More

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http://dx.doi.org/10.1002/cne.24690DOI Listing

Molecular architecture of the zebra finch arcopallium.

J Comp Neurol 2019 Mar 28. Epub 2019 Mar 28.

Department of Behavioral Neuroscience, OHSU, Portland, OR 97221.

The arcopallium, a key avian forebrain region, receives inputs from numerous brain areas and is a major source of descending sensory and motor projections. While there is evidence of arcopallial subdivisions, the internal organization or the arcopallium is not well understood. The arcopallium is also considered the avian homologue of mammalian deep cortical layers and/or amygdalar subdivisions, but one-to-one correspondences are controversial. Read More

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http://dx.doi.org/10.1002/cne.24688DOI Listing

Central and peripheral innervation patterns of defined axial motor units in larval zebrafish.

J Comp Neurol 2019 Mar 28. Epub 2019 Mar 28.

Interdepartmental Neuroscience Postbaccalaureate Research Education Program, Northwestern University, Evanston, Illinois.

Spinal motor neurons and the peripheral muscle fibers they innervate form discrete motor units that execute movements of varying force and speed. Subsets of spinal motor neurons also exhibit axon collaterals that influence motor output centrally. Here, we have used in vivo imaging to anatomically characterize the central and peripheral innervation patterns of axial motor units in larval zebrafish. Read More

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http://dx.doi.org/10.1002/cne.24689DOI Listing

The entire trajectories of single pontocerebellar axons and their lobular and longitudinal terminal distribution patterns in multiple aldolase C-positive compartments of the rat cerebellar cortex.

J Comp Neurol 2019 Mar 18. Epub 2019 Mar 18.

Department of Systems Neurophysiology, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.

The mammalian cerebellar cortex is compartmentalized, both anatomically and histochemically, into multiple parasagittal bands. To characterize the multiple zonal patterns of pontocerebellar mossy fiber projection, single neurons in the basilar pontine nucleus (BPN) were labeled by injecting biotinylated dextran amine into the BPN, and the entire axonal trajectory of single labeled neurons (n = 25) was reconstructed in relation to aldolase C compartments of Purkinje cells in rats. Single pontocerebellar axons, after passing through the contralateral middle cerebellar peduncle, ran transversely in the deep cerebellar white matter toward and often across the midline, and on their ways, gave rise to 2-10 primary collaterals at almost right angles in specific lobules only contralaterally or bilaterally with contralateral predominance. Read More

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http://dx.doi.org/10.1002/cne.24685DOI Listing

Differential expression and subcellular localization of Copines in mouse retina.

J Comp Neurol 2019 Mar 13. Epub 2019 Mar 13.

Retinal Circuit Development & Genetics Unit, Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute, NIH, Bethesda, Maryland.

Combinatorial expression of Brn3 transcription factors is required for the development of cell-specific morphologies in retinal ganglion cells (RGCs). The molecular mechanisms by which Brn3s regulate RGC type specific features are largely unexplored. We previously identified several members of the Copine (Cpne) family of molecules as potential targets of Brn3 transcription factors in the retina. Read More

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http://dx.doi.org/10.1002/cne.24684DOI Listing

Regional differences in mitral cell development in mouse olfactory bulb.

J Comp Neurol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania.

Olfactory sensory neurons (OSNs) located in the dorsomedial and ventromedial regions of the olfactory epithelium (OE) are distinguished from one another based on their molecular expression patterns. This difference is reflected in the separation of the glomerular layer of the olfactory bulb (OB) into dorsomedial and ventrolateral regions. However, it is unclear whether a complementary separation is also evident in the projection neurons that innervate the OB glomeruli. Read More

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http://dx.doi.org/10.1002/cne.24683DOI Listing

New viral-genetic mapping uncovers an enrichment of corticotropin-releasing hormone-expressing neuronal inputs to the nucleus accumbens from stress-related brain regions.

J Comp Neurol 2019 Mar 12. Epub 2019 Mar 12.

Department of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.

Corticotropin-releasing hormone (CRH) is an essential, evolutionarily-conserved stress neuropeptide. In addition to hypothalamus, CRH is expressed in brain regions including amygdala and hippocampus where it plays crucial roles in modulating the function of circuits underlying emotion and cognition. CRH fibers are found in nucleus accumbens (NAc), where CRH modulates reward/motivation behaviors. Read More

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http://dx.doi.org/10.1002/cne.24676DOI Listing

Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha.

J Comp Neurol 2019 Mar 12. Epub 2019 Mar 12.

Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota.

Within the supraoptic nucleus (SON) of a 35-day-old rat, we previously demonstrated a collateral sprouting response that reinnervates the partially denervated neural lobe (NL) after unilateral lesion of the hypothalamo-neurohypophysial tract. Others have shown a decreased propensity for axonal sprouting in an aged brain; therefore, to see if the SON exhibits a decreased propensity for axonal sprouting as the animal ages, we performed a unilateral lesion in the 125-day-old rat SON. Ultrastructural analysis of axon profiles in the NL of the 125-day-old rat demonstrated an absence of axonal sprouting following injury. Read More

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http://dx.doi.org/10.1002/cne.24675DOI Listing

Proportional loss of parvalbumin-immunoreactive synaptic boutons and granule cells from the hippocampus of sea lions with temporal lobe epilepsy.

J Comp Neurol 2019 Mar 12. Epub 2019 Mar 12.

Department of Comparative Medicine, Stanford University, Stanford, California.

One in 26 people develop epilepsy and in these temporal lobe epilepsy (TLE) is common. Many patients display a pattern of neuron loss called hippocampal sclerosis. Seizures usually start in the hippocampus but underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.1002/cne.24680DOI Listing

Altered cochlear innervation in developing and mature naked and Damaraland mole rats.

J Comp Neurol 2019 Mar 12. Epub 2019 Mar 12.

Department of Otorhinolaryngology and Head/Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Compared to many other rodent species, naked mole rats (Heterocephalus glaber) have elevated auditory thresholds, poor frequency selectivity, and limited ability to localize sound. Because the cochlea is responsible for encoding and relaying auditory signals to the brain, we used immunofluorescence and quantitative image analysis to examine cochlear innervation in mature and developing naked mole rats compared to mice (Mus musculus), gerbils (Meriones unguiculatus), and Damaraland mole rats (Fukomys damarensis), another subterranean rodent. In comparison to mice and gerbils, we observed alterations in afferent and efferent innervation as well as their patterns of developmental refinement in naked and Damaraland mole rats. Read More

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http://dx.doi.org/10.1002/cne.24682DOI Listing

Targets of olivocochlear collaterals in cochlear nucleus of rat and guinea pig.

J Comp Neurol 2019 Mar 12. Epub 2019 Mar 12.

The Auditory Laboratory, School of Human Sciences, University of Western Australia, Crawley, Western Australia, Australia.

Descending auditory pathways can modify afferent auditory input en route to cortex. One component of these pathways is the olivocochlear system which originates in brainstem and terminates in cochlea. Medial olivocochlear (MOC) neurons also project collaterals to cochlear nucleus and make synaptic contacts with dendrites of multipolar neurons. Read More

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http://dx.doi.org/10.1002/cne.24681DOI Listing

Mushroom bodies in crustaceans: Insect-like organization in the caridid shrimp Lebbeus groenlandicus.

J Comp Neurol 2019 Mar 12. Epub 2019 Mar 12.

Department of Neuroscience, School of Mind, Brain and Behavior, University of Arizona, Tucson, Arizona.

Paired centers in the forebrain of insects, called the mushroom bodies, have become the most investigated brain region of any invertebrate due to novel genetic strategies that relate unique morphological attributes of these centers to their functional roles in learning and memory. Mushroom bodies possessing all the morphological attributes of those in dicondylic insects have been identified in mantis shrimps, basal hoplocarid crustaceans that are sister to Eumalacostraca, the most species-rich group of Crustacea. However, unless other examples of mushroom bodies can be identified in Eumalacostraca, the possibility is that mushroom body-like centers may have undergone convergent evolution in Hoplocarida and are unique to this crustacean lineage. Read More

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http://dx.doi.org/10.1002/cne.24678DOI Listing

ROCK inhibition improves axonal regeneration in a preclinical model of amyotrophic lateral sclerosis.

J Comp Neurol 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurology, University Hospital of Cologne, Cologne, Germany.

Alteration of the RhoA/ROCK (Rho kinase) pathway has been shown to be neuroprotective in SOD1 mice, the most commonly used animal model of ALS. Since previous studies indicate that, apart from neuroprotection, ROCK inhibitor Y-27632 can also accelerate regeneration of motor axons, we here assessed the regenerative capability of axons in SOD1 mice with and without treatment with Y-27632. Regeneration of axons was examined after sciatic nerve crush in pre- and symptomatic SOD1 mice. Read More

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http://doi.wiley.com/10.1002/cne.24679
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http://dx.doi.org/10.1002/cne.24679DOI Listing
March 2019
3 Reads

Variations in the proliferative activity of the peripheral retina correlate with postnatal ocular growth in squamate reptiles.

J Comp Neurol 2019 Mar 12. Epub 2019 Mar 12.

Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

The retina is a complex, multilayered tissue responsible for the perception of visual stimuli from the environment. Contrary to mammals, the capacity for postnatal eye growth in fish and amphibians, and to a lower extent in birds, is coordinated with a progenitor population residing in the ciliary marginal zone (CMZ) at the retinal peripheral margin. However, little is known about embryonic retinogenesis and postnatal retinal growth in squamates (lizards, snakes), despite their exceptional array of ecologies and ocular morphologies. Read More

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http://dx.doi.org/10.1002/cne.24677DOI Listing

Single-neuron axonal reconstruction: The search for a wiring diagram of the brain.

J Comp Neurol 2019 Mar 12. Epub 2019 Mar 12.

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia.

Reconstruction of the axonal projection patterns of single neurons has been an important tool for understanding both the diversity of cell types in the brain and the logic of information flow between brain regions. Innovative approaches now enable the complete reconstruction of axonal projection patterns of individual neurons with vastly increased throughput. Here, we review how advances in genetic, imaging, and computational techniques have been exploited for axonal reconstruction. Read More

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http://dx.doi.org/10.1002/cne.24674DOI Listing
March 2019
4 Reads

Gad1-promotor-driven GFP expression in non-GABAergic neurons of the nucleus endopiriformis in a transgenic mouse line.

J Comp Neurol 2019 Mar 8. Epub 2019 Mar 8.

Department of Physiological Genomics, Biomedical Center, Ludwig-Maximilians-University, Munich, Germany.

Transgenic animals have become a widely used model to identify and study specific cell types in whole organs. Promotor-driven reporter gene labeling of the cells under investigation has promoted experimental efficacy to a large degree. However, rigorous assessment of transgene expression specificity in these animal models is highly recommended to validate cellular identity and to isolate potentially mislabeled cell populations. Read More

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http://dx.doi.org/10.1002/cne.24673DOI Listing

Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair.

J Comp Neurol 2019 Mar 6. Epub 2019 Mar 6.

Université de La Réunion, INSERM, UMR 1188, Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI), Saint-Denis de La Réunion, France.

Adiponectin and its receptors (adipor) have been initially characterized for their role in lipid and glucose metabolism. More recently, adiponectin signaling was shown to display anti-inflammatory effects and to participate in brain homeostasis and neuroprotection. In this study, we investigated adipor gene expression and its regulation under inflammatory conditions in two complementary models: mouse and zebrafish. Read More

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http://dx.doi.org/10.1002/cne.24669DOI Listing
March 2019
1 Read
3.225 Impact Factor

Effect of bilateral carotid occlusion on cerebral hemodynamics and perivascular innervation: An experimental rat model.

J Comp Neurol 2019 Mar 6. Epub 2019 Mar 6.

Department of Anatomy, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

We aimed to investigate the effect of chronic cerebral hypoperfusion on cerebral hemodynamics and perivascular nerve density in a rat model. Bilateral common carotid artery (CCA) ligation (n = 24) or sham-operation (n = 24) was performed with a 1-week interval. A subgroup (ligated n = 6; sham-operated n = 3) underwent magnetic resonance imaging (MRI) before the procedures and 2 and 4 weeks after the second procedure. Read More

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http://dx.doi.org/10.1002/cne.24672DOI Listing
March 2019
1 Read

The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform.

J Comp Neurol 2019 Feb 27. Epub 2019 Feb 27.

Novo Nordisk Research Center Seattle, Inc., Seattle, Washington.

Central activation of fibroblast growth factor (FGF) receptors regulates peripheral glucose homeostasis and reduces food intake in preclinical models of obesity and diabetes. The current work was undertaken to advance our understanding of the receptor expression, as sites of ligand action by FGF19, FGF21, and FGF1 in the mammalian brain remains unresolved. Recent advances in automated RNAscope in situ hybridization and droplet digital PCR (ddPCR) technology allowed us to interrogate central FGFR/beta klotho (Klb) system at the cellular level in the mouse, with relevant comparisons to nonhuman primate and human brain. Read More

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http://doi.wiley.com/10.1002/cne.24668
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http://dx.doi.org/10.1002/cne.24668DOI Listing
February 2019
24 Reads
3.225 Impact Factor

Morphological characteristics of p75 neurotrophin receptor-positive cells define a new type of glial cell in the rat dorsal root ganglia.

J Comp Neurol 2019 Feb 18. Epub 2019 Feb 18.

Department of Anatomy and Cell Science, Kansai Medical University, Hirakata, Osaka, Japan.

In the dorsal root ganglia (DRG), two types of glial cells (Schwann cells and satellite glial cells) have been identified based on cell morphology and expression of specific markers. In the present study, we observed unknown glial cells that were positive for p75 neurotrophin receptor (p75NTR), and therefore were immunohistochemically and ultrastructurally characterized for the first time. These cells exhibited stronger immunoreactivity against an anti-p75NTR antibody than the DRG neurons (hereafter referred to as p75NTR++ cells). Read More

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http://dx.doi.org/10.1002/cne.24667DOI Listing
February 2019

Evolutionarily conserved and divergent functions for cell adhesion molecules in neural circuit assembly.

Authors:
Byunghyuk Kim

J Comp Neurol 2019 Feb 18. Epub 2019 Feb 18.

Department of Life Science, Dongguk University Seoul, Goyang, Republic of Korea.

The developing nervous system generates remarkably precise synaptic connections between neurons and their postsynaptic target cells. Numerous neural cell adhesion proteins have been identified to mediate cell recognition between synaptic partners in several model organisms. Here, I review the role of protein interactions of cell adhesion molecules in neural circuit assembly and address how these interactions are utilized to form different neural circuitries in different species. Read More

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http://dx.doi.org/10.1002/cne.24666DOI Listing
February 2019

Cell type-specific distribution of GABA receptor subtypes in the mouse dorsal striatum.

J Comp Neurol 2019 Feb 18. Epub 2019 Feb 18.

Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

The striatum is the main input nucleus of the basal ganglia, mediating motor and cognitive functions. Striatal projection neurons are GABAergic medium spiny neurons (MSN), expressing either the dopamine receptor type 1 (D -R MSN) and forming the direct, movement-promoting pathway, or dopamine receptor type 2 (D -R MSN), forming the indirect movement-suppressing pathway. Locally, activity and synchronization of MSN are modulated by several subtypes of GABAergic and cholinergic interneurons. Read More

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http://dx.doi.org/10.1002/cne.24665DOI Listing
February 2019
1 Read

Differential expression of neurexin genes in the mouse brain.

J Comp Neurol 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts.

Synapses, highly specialized membrane junctions between neurons, connect presynaptic neurotransmitter release sites and postsynaptic ligand-gated channels. Neurexins (Nrxns), a family of presynaptic adhesion molecules, have been characterized as major regulators of synapse development and function. Via their extracellular domains, Nrxns bind to different postsynaptic proteins, generating highly diverse functional readouts through their postsynaptic binding partners. Read More

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http://dx.doi.org/10.1002/cne.24664DOI Listing
February 2019
2 Reads

Cortical Evolution Conference, 2018.

J Comp Neurol 2019 Jul 1;527(10):1543-1544. Epub 2019 Mar 1.

Psychiatry and Behavioral Sciences, UC Davis, Davis, California.

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http://dx.doi.org/10.1002/cne.24663DOI Listing

Seasonal comparison of the neuromuscular junction morphology of Bufo marinus.

J Comp Neurol 2019 Feb 9. Epub 2019 Feb 9.

Faculty of Medicine, School of Biomedical Sciences, The University of Queensland, Queensland, Australia.

At mammalian neuromuscular junctions (NMJs), prolonged inactivity leads to muscle denervation and atrophy. By contrast, amphibian NMJs do not show such degeneration even though they can remain in a state of drought-imposed dormancy (hibernation) for many years. We have previously reported that during the dry season, toad (Bufo marinus) NMJs display decreased sensitivity to extracellular calcium-dependent neurotransmitter release, which leads to minimal neuromuscular transmission. Read More

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http://dx.doi.org/10.1002/cne.24661DOI Listing
February 2019

Divergent projections of single pontocerebellar axons to multiple cerebellar lobules in the mouse.

J Comp Neurol 2019 Feb 9. Epub 2019 Feb 9.

Department of Systems Neurophysiology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

The basilar pontine nucleus (PN) is the key relay point for the cerebrocerebellar link. However, the projection pattern of pontocerebellar mossy fiber axons, which is essential in determining the functional organization of the cerebellar cortex, has not been fully clarified. We reconstructed the entire trajectory of 25 single pontocerebellar mossy fiber axons labeled by localized injection of biotinylated dextran amine into various locations in the PN and mapped all their terminals in an unfolded scheme of the cerebellum in 10 mice. Read More

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http://dx.doi.org/10.1002/cne.24662DOI Listing
February 2019

Concentric ring topology of mammalian cortical sectors and relevance for patterning studies.

J Comp Neurol 2019 Jul 22;527(10):1731-1752. Epub 2019 Feb 22.

Department of Human Anatomy and IMIB-Arrixaca Institute, School of Medicine, University of Murcia, Murcia, Spain.

Models aiming to explain causally the evolutionary or ontogenetic emergence of the pallial isocortex and its regional/areal heterogeneity in mammals use simple or complex assumptions about the pallial structure present in basal mammals and nonmammals. The question arises: how complex is the pattern that needs to be accounted for in causal models? This topic is also paramount for comparative purposes, since some topological relationships may be explained as being ancestral, rather than newly emerged. The mouse pallium is apt to be reexamined in this context, due to the breadth of available molecular markers and correlative experimental patterning results. Read More

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http://dx.doi.org/10.1002/cne.24650DOI Listing
July 2019
1 Read

Expression of cholecystokinin by neurons in mouse spinal dorsal horn.

J Comp Neurol 2019 Feb 8. Epub 2019 Feb 8.

Institute of Neuroscience and Psychology, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Excitatory interneurons account for the majority of dorsal horn neurons, and are required for perception of normal and pathological pain. We have identified largely non-overlapping populations in laminae I-III, based on expression of substance P, gastrin-releasing peptide, neurokinin B, and neurotensin. Cholecystokinin (CCK) is expressed by many dorsal horn neurons, particularly in the deeper laminae. Read More

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http://dx.doi.org/10.1002/cne.24657DOI Listing
February 2019

Brain mapping of the gonadotropin-inhibitory hormone-related peptide 2 with a novel antibody suggests a connection with emotional reactivity in the Japanese quail (Coturnix japonica, Temminck & Schlegel, 1849).

J Comp Neurol 2019 Feb 7. Epub 2019 Feb 7.

INRA, UMR85 Physiologie de la Reproduction et des Comportements; CNRS, UMR7247, Université de Tours, IFCE, Nouzilly, France.

Gonadotropin-inhibitory hormone (GnIH) is a neuropeptide first discovered in the quail brain that is involved in the control of reproductive physiology and behaviors, and stress response. GnIH gene encodes a second peptide, GnIH-related peptide-2 (RP2), the distribution and function of which remain unknown. We therefore studied GnIH-RP2 distribution by immunohistochemistry using a novel antibody capable of discriminating between GnIH and GnIH-RP2. Read More

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http://dx.doi.org/10.1002/cne.24659DOI Listing
February 2019
2 Reads

Development of hair cell phenotype and calyx nerve terminals in the neonatal mouse utricle.

J Comp Neurol 2019 Feb 6. Epub 2019 Feb 6.

Department of Otolaryngology-Head and Neck Surgery and the Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington.

The vestibular organs of reptiles, birds, and mammals possess Type I and Type II sensory hair cells, which have distinct morphologies, physiology, and innervation. Little is known about how vestibular hair cells adopt a Type I or Type II identity or acquire proper innervation. One distinguishing marker is the transcription factor Sox2, which is expressed in all developing hair cells but persists only in Type II hair cells in maturity. Read More

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http://dx.doi.org/10.1002/cne.24658DOI Listing
February 2019
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Moth pheromone-selective projection neurons with cell bodies in the antennal lobe lateral cluster exhibit diverse morphological and neurophysiological characteristics.

J Comp Neurol 2019 May 5;527(9):1443-1460. Epub 2019 Feb 5.

School of Biological Sciences, University of Utah, Salt Lake City, Utah.

Olfactory projection neurons convey information from the insect antennal lobe (AL) to higher brain centers. Previous reports have demonstrated that pheromone-responsive projection neurons with cell bodies in the moth medial cell cluster (mcPNs) predominantly have dendritic arborizations in the sexually dimorphic macroglomerular complex (MGC) and send an axon from the AL to the calyces of the mushroom body (CA) as well as the lateral horn (LH) of the protocerebrum via the medial AL tract. These neurons typically exhibit a narrow odor tuning range related to the restriction of their dendritic arbors within a single glomerulus (uniglomerular). Read More

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http://dx.doi.org/10.1002/cne.24611DOI Listing
May 2019
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Functional connectivity changes in core resting state networks are associated with cognitive performance in systemic lupus erythematosus.

J Comp Neurol 2019 Feb 1. Epub 2019 Feb 1.

Division of Clinical Radiology, Department of Clinical Sciences, Lund University, Lund, Sweden.

To investigate core resting state networks in SLE patients with and without neuropsychiatric symptoms by examining functional connectivity changes correlating with results of cognitive testing. Structural MRI and resting state-fMRI (rs-fMRI) were performed in 61 female SLE patients (mean age: 36.8 years, range 18. Read More

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http://dx.doi.org/10.1002/cne.24656DOI Listing
February 2019
4 Reads

Spinal cord injury transiently alters Meissner's corpuscle density in the digit pads of macaque monkeys.

J Comp Neurol 2019 Feb 1. Epub 2019 Feb 1.

Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California.

Meissner's corpuscles (MCs) are cutaneous mechanoreceptors found in glabrous skin and are exquisitely sensitive to light touch. Along with other receptors, they provide continuous sensory feedback that informs the execution of fine manual behaviors. Following cervical spinal deafferentation injuries, hand use can be initially severely impaired, but substantial recovery occurs over many weeks, even when ~95% of the original input is permanently lost. Read More

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http://dx.doi.org/10.1002/cne.24655DOI Listing
February 2019
14 Reads

The expression of tyrosine hydroxylase and DARPP-32 in the house crow (Corvus splendens) brain.

J Comp Neurol 2019 Jan 29. Epub 2019 Jan 29.

Division of Systems Neuroscience, National Brain Research Centre, Gurugram, Haryana, India.

Birds of the family Corvidae which includes diverse species such as crows, rooks, ravens, magpies, jays, and jackdaws are known for their amazing abilities at problem-solving. Since the catecholaminergic system, especially the neurotransmitter dopamine, plays a role in cognition, we decided to study the distribution of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines in the brain of house crows (Corvus splendens). We also studied the expression of DARPP-32 (dopamine and cAMP-regulated phosphoprotein), which is expressed in dopaminoceptive neurons. Read More

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http://dx.doi.org/10.1002/cne.24649DOI Listing
January 2019
2 Reads

Brain atlas of the African mole-rat Fukomys anselli.

J Comp Neurol 2019 Jan 29. Epub 2019 Jan 29.

Department of General Zoology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.

African mole-rats are subterranean rodents that spend their whole life in underground burrow systems. They show a range of morphological and physiological adaptations to their ecotope, for instance severely reduced eyes and specialized somatosensory, olfactory, and auditory systems. These adaptations are also reflected in the accessory sensory pathways in the brain that process the input coming from the sensory organs. Read More

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http://doi.wiley.com/10.1002/cne.24647
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http://dx.doi.org/10.1002/cne.24647DOI Listing
January 2019
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Shared and differential features of Robo3 expression pattern in amniotes.

J Comp Neurol 2019 Jan 29. Epub 2019 Jan 29.

Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.

In Bilaterians, commissural neurons project their axons across the midline of the nervous system to target neurons on the opposite side. In mammals, midline crossing at the level of the hindbrain and spinal cord requires the Robo3 receptor which is transiently expressed by all commissural neurons. Unlike other Robo receptors, mammalian Robo3 receptors do not bind Slit ligands and promote midline crossing. Read More

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http://dx.doi.org/10.1002/cne.24648DOI Listing
January 2019
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A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains.

J Comp Neurol 2019 May 6;527(9):1461-1477. Epub 2019 Feb 6.

Department of Neurobiology, University of Chicago, Chicago, Illinois.

In the mouse, two telencephalic signaling centers orchestrate embryonic patterning of the cerebral cortex. From the rostral patterning center in the telencephalon, the Fibroblast Growth Factor, FGF8, disperses as a morphogen to establish the rostral to caudal axis of the neocortical area map. FGF8 coordinates with Wnt3a from the cortical hem to regulate graded expression of transcription factors that position neocortical areas, and control hippocampal development. Read More

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http://dx.doi.org/10.1002/cne.24643DOI Listing

Evaluation of medial division of the medial geniculate (MGM) and posterior intralaminar nucleus (PIN) inputs to the rat auditory cortex, amygdala, and striatum.

J Comp Neurol 2019 May 8;527(9):1478-1494. Epub 2019 Feb 8.

Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

The medial division of the medial geniculate (MGM) and the posterior intralaminar nucleus (PIN) are association nuclei of the auditory thalamus. We made tracer injections in these nuclei to evaluate/compare their presynaptic terminal and postsynaptic target features in auditory cortex, amygdala and striatum, at the light and electron microscopic levels. Cortical labeling was concentrated in Layer 1 but in other layers distribution was location-dependent. Read More

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http://dx.doi.org/10.1002/cne.24644DOI Listing
May 2019
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Pattern of nitrergic cells and fibers organization in the central nervous system of the Australian lungfish, Neoceratodus forsteri (Sarcopterygii: Dipnoi).

J Comp Neurol 2019 Jan 28. Epub 2019 Jan 28.

Department of Cell Biology, Faculty of Biology, University Complutense of Madrid, Madrid, Spain.

The Australian lungfish Neoceratodus forsteri is the only extant species of the order Ceratodontiformes, which retained most of the primitive features of ancient lobe finned-fishes. Lungfishes are the closest living relatives of land vertebrates and their study is important for deducing the neural traits that were conserved, modified, or lost with the transition from fishes to land vertebrates. We have investigated the nitrergic system with neural nitric oxide synthase (NOS) immunohistochemistry and NADPH-diaphorase (NADPH-d) histochemistry, which yielded almost identical results except for the primary olfactory projections and the terminal and preoptic nerve fibers labeled only for NADPH-d. Read More

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http://dx.doi.org/10.1002/cne.24645DOI Listing
January 2019
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Developmental changes in interkinetic nuclear migration dynamics with respect to cell-cycle progression in the mouse cerebral cortex ventricular zone.

J Comp Neurol 2019 Jul 6;527(10):1545-1557. Epub 2019 Feb 6.

Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, France.

We have examined the relationship between interkinetic nuclear migration (INM) and cell-cycle progression of apical progenitors in the ventricular zone (VZ) at different stages of mouse cerebral corticogenesis. We report stage-specific changes in INM due to a significant alteration of the nuclear apical movement dynamics with respect to cell-cycle phases. While at early stages, the apical nuclear movement corresponds to the G2 phase, cell-cycle phase specific immunostaining and real-time imaging of PCNA expressing apical progenitors revealed that at midcorticogenesis, the nuclear apical movement is initiated well before the entry into G2, during S phase. Read More

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http://dx.doi.org/10.1002/cne.24641DOI Listing
July 2019
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Prehensile kinematics of the marmoset monkey: Implications for the evolution of visually-guided behaviors.

J Comp Neurol 2019 May 11;527(9):1495-1507. Epub 2019 Feb 11.

Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.

Throughout the primate lineage, there is a wide diversity of prehensile capacity that is thought to stem from individual species foraging patterns. While many studies have explored primates with precise hand grips, such as higher apes, few have considered primates that lack opposition movements. The New World marmoset monkey occupies an intriguing niche, displaying adept control of their hand movements yet their absence of opposable digits results in relatively imprecise grasping actions when compared with those observed in Old World monkeys, apes, and humans. Read More

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http://dx.doi.org/10.1002/cne.24639DOI Listing
May 2019
2 Reads