17,525 results match your criteria Journal of Comparative Neurology[Journal]


Morphological characteristics of p75 neurotrophin receptor-positive cells define a new type of glial cell in the rat dorsal root ganglia.

J Comp Neurol 2019 Feb 18. Epub 2019 Feb 18.

Department of Anatomy and Cell Science, Kansai Medical University, Hirakata City, Osaka, Japan.

In the dorsal root ganglia (DRG), two types of glial cells (Schwann cells and satellite glial cells) have been identified based on cell morphology and expression of specific markers. In the present study, we observed unknown glial cells that were positive for p75 neurotrophin receptor (p75NTR), and therefore were immunohistochemically and ultrastructurally characterized for the first time. These cells exhibited stronger immunoreactivity against an anti-p75NTR antibody than the DRG neurons (hereafter referred to as p75NTR++ cells). Read More

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http://dx.doi.org/10.1002/cne.24667DOI Listing
February 2019

Evolutionarily conserved and divergent functions for cell adhesion molecules in neural circuit assembly.

Authors:
Byunghyuk Kim

J Comp Neurol 2019 Feb 18. Epub 2019 Feb 18.

Department of Life Science, Dongguk University-Seoul, Goyang, Republic of Korea.

The developing nervous system generates remarkably precise synaptic connections between neurons and their postsynaptic target cells. Numerous neural cell adhesion proteins have been identified to mediate cell recognition between synaptic partners in several model organisms. Here, I review the role of protein interactions of cell adhesion molecules in neural circuit assembly and address how these interactions are utilized to form different neural circuitries in different species. Read More

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http://dx.doi.org/10.1002/cne.24666DOI Listing
February 2019

Cell type-specific distribution of GABA receptor subtypes in the mouse dorsal striatum.

J Comp Neurol 2019 Feb 18. Epub 2019 Feb 18.

University of Zurich, Institute of Pharmacology and Toxicology, Zurich, Switzerland.

The striatum is the main input nucleus of the basal ganglia, mediating motor and cognitive functions. Striatal projection neurons are GABAergic medium spiny neurons (MSN), expressing either the dopamine receptor type 1 (D -R MSN) and forming the direct, movement-promoting pathway, or dopamine receptor type 2 (D -R MSN), forming the indirect movement-suppressing pathway. Locally, activity and synchronization of MSN are modulated by several subtypes of GABAergic and cholinergic interneurons. Read More

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http://dx.doi.org/10.1002/cne.24665DOI Listing
February 2019

Differential Expression of Neurexin Genes in the Mouse Brain.

J Comp Neurol 2019 Feb 13. Epub 2019 Feb 13.

Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, LRB-706 Worcester, MA, USA.

Synapses, highly specialized membrane junctions between neurons, connect presynaptic neurotransmitter release sites and postsynaptic ligand-gated channels. Neurexins (Nrxns), a family of the presynaptic adhesion molecules, have been characterized as major regulators of synapse development and function. Via their extracellular domains, Nrxns bind to different postsynaptic proteins, generating highly diverse functional readouts through their postsynaptic binding partners. Read More

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http://dx.doi.org/10.1002/cne.24664DOI Listing
February 2019
2 Reads

Cortical Evolution Conference, 2018.

J Comp Neurol 2019 Feb 10. Epub 2019 Feb 10.

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http://dx.doi.org/10.1002/cne.24663DOI Listing
February 2019

A seasonal comparison of the neuromuscular junction morphology of Buffo Marinus.

J Comp Neurol 2019 Feb 9. Epub 2019 Feb 9.

School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, QLD, Australia.

At mammalian neuromuscular junctions (NMJs), prolonged inactivity leads to muscle denervation and atrophy. By contrast, amphibian NMJs do not show such degeneration even though they can remain in a state of drought-imposed dormancy (hibernation) for many years. We have previously reported that during the dry season, toad (Bufo marinus) NMJs display decreased sensitivity to extracellular calcium dependent neurotransmitter release, which leads to minimal neuromuscular transmission. Read More

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http://dx.doi.org/10.1002/cne.24661DOI Listing
February 2019

Divergent projections of single pontocerebellar axons to multiple cerebellar lobules in the mouse.

J Comp Neurol 2019 Feb 9. Epub 2019 Feb 9.

Department of Systems Neurophysiology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

The basilar pontine nucleus (PN) is the key relay point for the cerebrocerebellar link. However, the projection pattern of pontocerebellar mossy fiber axons, which is essential in determining the functional organization of the cerebellar cortex, has not been fully clarified. We reconstructed the entire trajectory of 25 single pontocerebellar mossy fiber axons labeled by localized injection of biotinylated dextran amine into various locations in the PN and mapped all their terminals in an unfolded scheme of the cerebellum in 10 mice. Read More

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http://dx.doi.org/10.1002/cne.24662DOI Listing
February 2019

Concentric ring topology of mammalian cortical sectors and relevance for patterning studies.

J Comp Neurol 2019 Feb 9. Epub 2019 Feb 9.

Department of Human Anatomy and IMIB-Arrixaca Institute, School of Medicine, University of Murcia.

Models aiming to explain causally the evolutionary or ontogenetic emergence of the pallial isocortex and its regional/areal heterogeneity in mammals use simple or complex assumptions about the pallial structure present in basal mammals and non-mammals. The question arises: how complex is the pattern that needs to be accounted for in causal models? This topic is also paramount for comparative purposes, since some topological relationships may be explained as being ancestral, rather than newly emerged. The mouse pallium is apt to be reexamined in this context, due to the breadth of available molecular markers and correlative experimental patterning results. Read More

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http://dx.doi.org/10.1002/cne.24650DOI Listing
February 2019
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Expression of cholecystokinin by neurons in mouse spinal dorsal horn.

J Comp Neurol 2019 Feb 8. Epub 2019 Feb 8.

Institute of Neuroscience and Psychology, West Medical Building, University of Glasgow, Glasgow, G12 8QQ, UK.

Excitatory interneurons account for the majority of dorsal horn neurons, and are required for perception of normal and pathological pain. We have identified largely non-overlapping populations in laminae I-III, based on expression of substance P, gastrin-releasing peptide, neurokinin B and neurotensin. Cholecystokinin (CCK) is expressed by many dorsal horn neurons, particularly in the deeper laminae. Read More

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http://dx.doi.org/10.1002/cne.24657DOI Listing
February 2019

Brain Mapping of the Gonadotropin-Inhibitory Hormone-Related Peptide 2 with a Novel Antibody Suggests a Connection with Emotional Reactivity in the Japanese Quail (Coturnix japonica, Temminck & Schlegel, 1849).

J Comp Neurol 2019 Feb 7. Epub 2019 Feb 7.

INRA, UMR85 Physiologie de la Reproduction et des Comportements ; CNRS, UMR7247, Université de Tours, Nouzilly, France.

Gonadotropin-inhibitory hormone (GnIH) is a neuropeptide first discovered in the quail brain that is involved in the control of reproductive physiology and behaviors, and stress response. GnIH gene encodes a second peptide, GnIH-related peptide-2 (RP2), the distribution and function of which remain unknown. We therefore studied GnIH-RP2 distribution by immunohistochemistry using a novel antibody capable of discriminating between GnIH and GnIH-RP2. Read More

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http://dx.doi.org/10.1002/cne.24659DOI Listing
February 2019

Development of hair cell phenotype and calyx nerve terminals in the neonatal mouse utricle.

J Comp Neurol 2019 Feb 6. Epub 2019 Feb 6.

Department of Otolaryngology-Head and Neck Surgery and the Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA.

The vestibular organs of reptiles, birds, and mammals possess type I and type II sensory hair cells, which have distinct morphologies, physiology, and innervation. Little is known about how vestibular hair cells adopt a type I or type II identity or acquire proper innervation. One distinguishing marker is the transcription factor Sox2, which is expressed in all developing hair cells but persists only in type II hair cells in maturity. Read More

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http://dx.doi.org/10.1002/cne.24658DOI Listing
February 2019
1 Read

Moth pheromone-selective projection neurons with cell bodies in the antennal lobe lateral cluster exhibit diverse morphological and neurophysiological characteristics.

J Comp Neurol 2019 Feb 5. Epub 2019 Feb 5.

School of Biological Sciences, University of Utah, Salt Lake City, Utah.

Olfactory projection neurons convey information from the insect antennal lobe (AL) to higher brain centers. Previous reports have demonstrated that pheromone-responsive projection neurons with cell bodies in the moth medial cell cluster (mcPNs) predominantly have dendritic arborizations in the sexually dimorphic macroglomerular complex (MGC) and send an axon from the AL to the calyces of the mushroom body (CA) as well as the lateral horn (LH) of the protocerebrum via the medial AL tract. These neurons typically exhibit a narrow odor tuning range related to the restriction of their dendritic arbors within a single glomerulus (uniglomerular). Read More

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http://dx.doi.org/10.1002/cne.24611DOI Listing
February 2019
1 Read

Functional connectivity changes in core resting state networks are associated with cognitive performance in systemic lupus erythematosus.

J Comp Neurol 2019 Feb 1. Epub 2019 Feb 1.

Division of Clinical Radiology, Department of Clinical Sciences, Lund University, Lund, Sweden.

To investigate core resting state networks in SLE patients with and without neuropsychiatric symptoms by examining functional connectivity changes correlating with results of cognitive testing. Structural MRI and resting state-fMRI (rs-fMRI) were performed in 61 female SLE patients (mean age: 36.8 years, range 18. Read More

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http://dx.doi.org/10.1002/cne.24656DOI Listing
February 2019
3 Reads

Spinal cord injury transiently alters Meissner's corpuscle density in the digit pads of macaque monkeys.

J Comp Neurol 2019 Feb 1. Epub 2019 Feb 1.

Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Meissner's corpuscles (MCs) are cutaneous mechanoreceptors found in glabrous skin and are exquisitely sensitive to light touch. Along with other receptors, they provide continuous sensory feedback that informs the execution of fine manual behaviors. Following cervical spinal deafferentation injuries, hand use can be initially severely impaired, but substantial recovery occurs over many weeks, even when ~95% of the original input is permanently lost. Read More

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http://dx.doi.org/10.1002/cne.24655DOI Listing
February 2019

The expression of tyrosine hydroxylase and DARPP-32 in the house crow (Corvus splendens) brain.

J Comp Neurol 2019 Jan 29. Epub 2019 Jan 29.

Division of Systems Neuroscience, National Brain Research Centre, Gurugram, Haryana, India.

Birds of the family Corvidae which includes diverse species such as crows, rooks, ravens, magpies, jays, and jackdaws are known for their amazing abilities at problem-solving. Since the catecholaminergic system, especially the neurotransmitter dopamine, plays a role in cognition, we decided to study the distribution of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catecholamines in the brain of house crows (Corvus splendens). We also studied the expression of DARPP-32 (dopamine and cAMP-regulated phosphoprotein), which is expressed in dopaminoceptive neurons. Read More

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http://dx.doi.org/10.1002/cne.24649DOI Listing
January 2019
1 Read

Brain atlas of the African mole-rat Fukomys anselli.

J Comp Neurol 2019 Jan 29. Epub 2019 Jan 29.

Department of General Zoology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.

African mole-rats are subterranean rodents that spend their whole life in underground burrow systems. They show a range of morphological and physiological adaptations to their ecotope, for instance severely reduced eyes and specialized somatosensory, olfactory and auditory systems. These adaptations are also reflected in the accessory sensory pathways in the brain that process the input coming from the sensory organs. Read More

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http://doi.wiley.com/10.1002/cne.24647
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http://dx.doi.org/10.1002/cne.24647DOI Listing
January 2019
2 Reads

Shared and differential features of Robo3 expression pattern in amniotes.

J Comp Neurol 2019 Jan 29. Epub 2019 Jan 29.

Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.

In Bilaterians, commissural neurons project their axons across the midline of the nervous system to target neurons on the opposite side. In mammals, midline crossing at the level of the hindbrain and spinal cord requires the Robo3 receptor which is transiently expressed by all commissural neurons. Unlike other Robo receptors, mammalian Robo3 receptors do not bind Slit ligands and promote midline crossing. Read More

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http://dx.doi.org/10.1002/cne.24648DOI Listing
January 2019
1 Read

A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains.

J Comp Neurol 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurobiology, University of Chicago, Chicago, Illinois.

In the mouse, two telencephalic signaling centers orchestrate embryonic patterning of the cerebral cortex. From the rostral patterning center in the telencephalon, the Fibroblast Growth Factor, FGF8, disperses as a morphogen to establish the rostral to caudal axis of the neocortical area map. FGF8 coordinates with Wnt3a from the cortical hem to regulate graded expression of transcription factors that position neocortical areas, and control hippocampal development. Read More

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http://dx.doi.org/10.1002/cne.24643DOI Listing
January 2019

Evaluation of medial division of the medial geniculate (MGM) and posterior intralaminar nucleus (PIN) inputs to the rat auditory cortex, amygdala, and striatum.

J Comp Neurol 2019 Jan 28. Epub 2019 Jan 28.

Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

The medial division of the medial geniculate (MGM) and the posterior intralaminar nucleus (PIN) are association nuclei of the auditory thalamus. We made tracer injections in these nuclei to evaluate/compare their presynaptic terminal and postsynaptic target features in auditory cortex, amygdala and striatum, at the light and electron microscopic levels. Cortical labeling was concentrated in Layer 1 but in other layers distribution was location-dependent. Read More

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http://dx.doi.org/10.1002/cne.24644DOI Listing
January 2019
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Pattern of nitrergic cells and fibers organization in the central nervous system of the Australian lungfish, Neoceratodus forsteri (Sarcopterygii: Dipnoi).

J Comp Neurol 2019 Jan 28. Epub 2019 Jan 28.

Department of Cell Biology, Faculty of Biology, University Complutense of Madrid, Madrid, Spain.

The Australian lungfish Neoceratodus forsteri is the only extant species of the order Ceratodontiformes, which retained most of the primitive features of ancient lobe finned-fishes. Lungfishes are the closest living relatives of land vertebrates and their study is important for deducing the neural traits that were conserved, modified, or lost with the transition from fishes to land vertebrates. We have investigated the nitrergic system with neural nitric oxide synthase (NOS) immunohistochemistry and NADPH-diaphorase (NADPH-d) histochemistry, which yielded almost identical results except for the primary olfactory projections and the terminal and preoptic nerve fibers labeled only for NADPH-d. Read More

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http://dx.doi.org/10.1002/cne.24645DOI Listing
January 2019

Developmental changes in interkinetic nuclear migration dynamics with respect to cell-cycle progression in the mouse cerebral cortex ventricular zone.

J Comp Neurol 2019 Jan 25. Epub 2019 Jan 25.

Univ Lyon, Université Claude Bernard Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, France.

We have examined the relationship between interkinetic nuclear migration (INM) and cell-cycle progression of apical progenitors in the ventricular zone (VZ) at different stages of mouse cerebral corticogenesis. We report stage-specific changes in INM due to a significant alteration of the nuclear apical movement dynamics with respect to cell-cycle phases. While at early stages, the apical nuclear movement corresponds to the G2 phase, cell-cycle phase specific immunostaining and real-time imaging of PCNA expressing apical progenitors revealed that at midcorticogenesis, the nuclear apical movement is initiated well before the entry into G2, during S phase. Read More

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http://dx.doi.org/10.1002/cne.24641DOI Listing
January 2019
2 Reads

Prehensile kinematics of the marmoset monkey: Implications for the evolution of visually-guided behaviors.

J Comp Neurol 2019 Jan 24. Epub 2019 Jan 24.

Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia.

Throughout the primate lineage, there is a wide diversity of prehensile capacity that is thought to stem from individual species foraging patterns. While many studies have explored primates with precise hand grips, such as higher apes, few have considered primates that lack opposition movements. The New World marmoset monkey occupies an intriguing niche, displaying adept control of their hand movements yet their absence of opposable digits results in relatively imprecise grasping actions when compared with those observed in Old World monkeys, apes, and humans. Read More

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http://dx.doi.org/10.1002/cne.24639DOI Listing
January 2019

The effect of Zika virus infection in the ferret.

J Comp Neurol 2019 Jan 24. Epub 2019 Jan 24.

Program in Neuroscience, USUHS, Bethesda, Maryland.

Although initial observations of infections with the Zika virus describe a mild illness, more recent reports show that infections by Zika result in neurotropism. In 2015, substantial congenital malformations were observed, with numerous infants born with microcephaly in Brazil. To study the underlying mechanism and effects of the disease, it is critical to find suitable animal models. Read More

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http://doi.wiley.com/10.1002/cne.24640
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http://dx.doi.org/10.1002/cne.24640DOI Listing
January 2019
2 Reads

Are we listening to everything the PARK genes are telling us?

J Comp Neurol 2019 Jan 24. Epub 2019 Jan 24.

Department of Neuroscience, Friedman Brain Institute and the Graduate School of Biomedical Sciences Icahn School of Medicine at Mount Sinai, New York, New York.

The cardinal motor symptoms that define Parkinson's disease (PD) clinically have been recognized for over 200 years. That these symptoms arise following the loss of dopamine neurons in the substantia nigra has been known for the last 50. These long-established facts have fueled a broadly held expectation that degenerating dopaminergic neurons alone hold the key to understanding and curing PD. Read More

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http://dx.doi.org/10.1002/cne.24642DOI Listing
January 2019
1 Read

Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri.

J Comp Neurol 2019 Jan 21. Epub 2019 Jan 21.

Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, Italy.

Orexin A (OXA) and neuropeptide Y (NPY) are two hypothalamic neuropeptides involved in the regulation of feeding behavior and food intake in all vertebrates. Accumulating evidences document that they undergo age-related modifications, with consequences on metabolism, sleep/wake disorders and progression of neurodegenerations. The present study addressed the age related changes in expression and distribution of orexin A (its precursor is also known as hypocretin-HCRT) and NPY, and their regulation by food intake in the short-lived vertebrate model Nothobranchius furzeri. Read More

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http://dx.doi.org/10.1002/cne.24638DOI Listing
January 2019
2 Reads

Expression of tachykinin3 and related reproductive markers in the brain of the African cichlid fish Astatotilapia burtoni.

J Comp Neurol 2019 Jan 15. Epub 2019 Jan 15.

Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana.

Neurokinin B, encoded by the tachykinin3 gene, plays a crucial role in regulating reproduction in mammals via KNDy neurons and interaction with GnRH. Previous work in teleost fishes has focused on hypothalamic tac3 expression for its role in reproduction, but detailed studies on extra-hypothalamic tac3 expression are limited. Here, we identified two tac3 genes in the social African cichlid fish Astatotilapia burtoni, only one of which produces a functional protein containing the signature tachykinin motif. Read More

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http://doi.wiley.com/10.1002/cne.24622
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http://dx.doi.org/10.1002/cne.24622DOI Listing
January 2019
4 Reads

Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex.

J Comp Neurol 2019 Jan 12. Epub 2019 Jan 12.

Department of Anatomy, Keio University School of Medicine, Tokyo, Japan.

During development of the mammalian cerebral neocortex, postmitotic excitatory neurons migrate toward the outermost region of the neocortex. We previously reported that this outermost region is composed of densely packed relatively immature neurons; we named this region, which is observed during the late stage of mouse neocortical development, the "primitive cortical zone (PCZ)." Here, we report that postmigratory immature neurons spend about 1-1. Read More

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http://dx.doi.org/10.1002/cne.24634DOI Listing
January 2019
1 Read

Automatic navigation system for the mouse brain.

J Comp Neurol 2019 Jan 12. Epub 2019 Jan 12.

MBF Bioscience, Williston, VT, USA.

Identification and delineation of brain regions in histologic mouse brain sections is especially pivotal for many neurogenomics, transcriptomics, proteomics and connectomics studies, yet this process is prone to observer error and bias. Here we present a novel brain navigation system, named NeuroInfo, whose general principle is similar to that of a global positioning system (GPS) in a car. NeuroInfo automatically navigates an investigator through the complex microscopic anatomy of histologic sections of mouse brains (thereafter: "experimental mouse brain sections"). Read More

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http://doi.wiley.com/10.1002/cne.24635
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http://dx.doi.org/10.1002/cne.24635DOI Listing
January 2019
3 Reads

Neural System and Receptor Diversity in the Ctenophore Beroe abyssicola.

J Comp Neurol 2019 Jan 11. Epub 2019 Jan 11.

Whitney Laboratory for Marine Biosciences, University of Florida, St. Augustine, FL, USA.

Although, neuro-sensory systems might have evolved independently in ctenophores, very little is known about their organization and functions. Most ctenophores are pelagic and deep-water species and cannot be bred in the laboratory. Thus, it is not surprising that neuroanatomical data are available for only one genus within the group - Pleurobrachia. Read More

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http://dx.doi.org/10.1002/cne.24633DOI Listing
January 2019
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Cortical and thalamic connectivity of posterior parietal visual cortical areas PPc and PPr of the domestic ferret (Mustela putorius furo).

J Comp Neurol 2019 Jan 11. Epub 2019 Jan 11.

School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

The present study describes the ipsilateral and contralateral cortico-cortical and cortico-thalamic connectivity of the parietal visual areas, posterior parietal caudal cortical area (PPc) and posterior parietal rostral cortical area (PPr), in the ferret using standard anatomical tract-tracing methods. The two divisions of posterior parietal cortex of the ferret are strongly interconnected, however area PPc shows stronger connectivity with the occipital and suprasylvian visual cortex, while area PPr shows stronger connectivity with the somatomotor cortex, reflecting the functional specificity of these two areas. This pattern of connectivity is mirrored in the contralateral callosal connections. Read More

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http://dx.doi.org/10.1002/cne.24630DOI Listing
January 2019
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Cortical and thalamic connectivity of temporal visual cortical areas 20a and 20b of the domestic ferret (Mustela putorius furo).

J Comp Neurol 2019 Jan 11. Epub 2019 Jan 11.

School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

The present study describes the ipsilateral and contralateral corticocortical and corticothalamic connectivity of the temporal visual areas 20a and 20b in the ferret using standard anatomical tract-tracing methods. The two temporal visual areas are strongly interconnected, but area 20a is primarily connected to the occipital visual areas, whereas area 20b maintains more widespread connections with the occipital, parietal and suprasylvian visual areas and the secondary auditory cortex. The callosal connectivity, although homotopic, consists mainly of very weak anterograde labeling which was more widespread in area 20a than area 20b. Read More

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http://doi.wiley.com/10.1002/cne.24632
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http://dx.doi.org/10.1002/cne.24632DOI Listing
January 2019
2 Reads

Cortical and thalamic connectivity of occipital visual cortical areas 17, 18, 19, and 21 of the domestic ferret (Mustela putorius furo).

J Comp Neurol 2019 Jan 11. Epub 2019 Jan 11.

School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

The present study describes the ipsilateral and contralateral corticocortical and corticothalamic connectivity of the occipital visual areas 17, 18, 19, and 21 in the ferret using standard anatomical tract-tracing methods. In line with previous studies of mammalian visual cortex connectivity, substantially more anterograde and retrograde label was present in the hemisphere ipsilateral to the injection site compared to the contralateral hemisphere. Ipsilateral reciprocal connectivity was the strongest within the occipital visual areas, while weaker connectivity strength was observed in the temporal, suprasylvian, and parietal visual areas. Read More

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http://dx.doi.org/10.1002/cne.24631DOI Listing
January 2019
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Selective Cre-mediated gene deletion identifies connexin 43 as the main connexin channel supporting olfactory ensheathing cell networks.

J Comp Neurol 2019 Jan 9. Epub 2019 Jan 9.

CONICET, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Neurociencia de Sistemas, Buenos Aires, Argentina.

Many functions of glial cells depend on the formation of selective glial networks mediated by gap junctions formed by members of the connexin family. Olfactory ensheathing cells (OECs) are specialized glia associated with olfactory sensory neuron axons. Like other glia, they form selective networks, however, the connexins that support OEC connectivity in vivo have not been identified. Read More

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http://dx.doi.org/10.1002/cne.24628DOI Listing
January 2019
3 Reads

Schwann cell guidance of nerve growth between synaptic sites explains changes in the pattern of muscle innervation and remodeling of synaptic sites following peripheral nerve injuries.

J Comp Neurol 2019 Jan 8. Epub 2019 Jan 8.

Department of Biology, Texas A&M University, College Station, Texas.

Terminal Schwann cells (SCs) are nonmyelinating glia that are a prominent component of the neuromuscular junction (NMJ) where motor neurons form synapses onto muscle fibers. These cells play important roles not only in development and maintenance of the neuromuscular synapse but also restoring synaptic function after nerve damage. In response to muscle denervation, terminal SCs undergo dramatic changes in their gene expression patterns as well as in their morphology, such as extending elaborate processes into inter-junctional space. Read More

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http://dx.doi.org/10.1002/cne.24625DOI Listing
January 2019
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Melatonin receptor expression in vocal, auditory, and neuroendocrine centers of a highly vocal fish, the plainfin midshipman (Porichthys notatus).

J Comp Neurol 2019 Jan 8. Epub 2019 Jan 8.

Department of Neurobiology and Behavior, Cornell University, Ithaca, New York.

Melatonin plays a central role in entraining activity to the day-night cycle in vertebrates. Here, we investigate neuroanatomical substrates of melatonin-dependent vocal-acoustic behavior in the nocturnal and highly vocal teleost fish, the plainfin midshipman (Porichthys notatus). Using in situ hybridization (ISH) and quantitative real-time PCR (qPCR), we assess the mRNA distribution and transcript abundance of melatonin receptor subtype 1B (mel1b), shown to be important for vocalization in midshipman fish and songbirds. Read More

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http://doi.wiley.com/10.1002/cne.24629
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http://dx.doi.org/10.1002/cne.24629DOI Listing
January 2019
5 Reads

Extrastriate connectivity of the mouse dorsal lateral geniculate thalamic nucleus.

J Comp Neurol 2019 Jan 8. Epub 2019 Jan 8.

USC Stevens Neuroimaging and Informatics Institute, Center for Integrative Connectomics, Keck School of Medicine of University of Southern California, Los Angeles, California.

The mammalian visual system is one of the most well-studied brain systems. Visual information from the retina is relayed to the dorsal lateral geniculate nucleus of the thalamus (LGd). The LGd then projects topographically to primary visual cortex (VISp) to mediate visual perception. Read More

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http://dx.doi.org/10.1002/cne.24627DOI Listing
January 2019
1 Read

Differential innervation within a transverse plane of spinal gray matter by sensorimotor cortices, with special reference to the somatosensory cortices.

J Comp Neurol 2019 Jan 8. Epub 2019 Jan 8.

Department of Physiology, Teikyo University School of Medicine, Tokyo, Japan.

The corticospinal (CS) neurons projecting to the cervical cord distribute not only in motor-related cortical areas, but also in somatosensory areas, including the primary somatosensory cortex (S1). The exact functions of these widely distributed CS neurons are largely unknown, however. In this study, we injected mice with adeno-associated virus encoding membrane-binding fluorescent proteins to investigate the distribution of axons from CS neurons in different regions within a broad cortical area. Read More

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http://doi.wiley.com/10.1002/cne.24626
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http://dx.doi.org/10.1002/cne.24626DOI Listing
January 2019
1 Read

Passages 2019.

Authors:
Patrick R Hof

J Comp Neurol 2019 Jan;527(1):3-6

The Journal of Comparative Neurology, Fishberg Department of Neuroscience, Icahn school of Medicine at Mount Sinai, New York, New York.

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http://doi.wiley.com/10.1002/cne.24587
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http://dx.doi.org/10.1002/cne.24587DOI Listing
January 2019
3 Reads

Introduction to retinal special issue I.

J Comp Neurol 2019 Jan;527(1):7-8

Department of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, Rhode Island.

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http://dx.doi.org/10.1002/cne.24599DOI Listing
January 2019
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Obituary: Anita Hendrickson, PhD.

J Comp Neurol 2019 Jan;527(1):11-12

Department of Ophthalmology, University of Washington, Seattle.

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http://dx.doi.org/10.1002/cne.24607DOI Listing
January 2019

Dedication of Retinal Special Issue to: Harvey J. Karten, M.D.

J Comp Neurol 2019 Jan;527(1):9-10

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http://dx.doi.org/10.1002/cne.24601DOI Listing
January 2019
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The brain of the tree pangolin (Manis tricuspis). V. The diencephalon and hypothalamus.

J Comp Neurol 2018 Dec 27. Epub 2018 Dec 27.

School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Republic of South Africa.

The diencephalon (dorsal thalamus, ventral thalamus, and epithalamus) and the hypothalamus, play central roles in the processing of the majority of neural information within the central nervous system. Given the interactions of the diencephalon and hypothalamus with virtually all portions of the central nervous system, the comparative analysis of these regions lend key insights into potential neural, evolutionary, and behavioral specializations in different species. Here, we continue our analysis of the brain of the tree pangolin by providing a comprehensive description of the organization of the diencephalon and hypothalamus using a range of standard and immunohistochemical staining methods. Read More

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http://dx.doi.org/10.1002/cne.24619DOI Listing
December 2018
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Fluoxetine delays the cognitive function decline and synaptic changes in a transgenic mouse model of early Alzheimer's disease.

J Comp Neurol 2018 Dec 27. Epub 2018 Dec 27.

Department of Histology and Embryology, Chongqing Medical University, Chongqing, China.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline. Previous studies have reported that the syndrome of AD begins with subtle alterations in hippocampal synapses prior to frank neuronal degeneration. It has recently been reported that fluoxetine (FLX) shows positive effects on AD patients who have depression and anxiety. Read More

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http://dx.doi.org/10.1002/cne.24616DOI Listing
December 2018
3 Reads
3.225 Impact Factor

Novel insights into the glia limitans of the olfactory nervous system.

J Comp Neurol 2018 Dec 27. Epub 2018 Dec 27.

Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia.

Olfactory ensheathing cells (OECs) are often described as being present in both the peripheral and the central nervous systems (PNS and CNS). Furthermore, the olfactory nervous system glia limitans (the glial layer defining the PNS-CNS border) is considered unique as it consists of intermingling OECs and astrocytes. In contrast, the glia limitans of the rest of the nervous system consists solely of astrocytes which create a distinct barrier to Schwann cells (peripheral glia). Read More

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http://doi.wiley.com/10.1002/cne.24618
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http://dx.doi.org/10.1002/cne.24618DOI Listing
December 2018
16 Reads
3.225 Impact Factor

The brain of the tree pangolin (Manis tricuspis). IV. The hippocampal formation.

J Comp Neurol 2018 Dec 27. Epub 2018 Dec 27.

School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Republic of South Africa.

Employing a range of standard and immunohistochemical stains we provide a description of the hippocampal formation in the brain of the tree pangolin. For the most part, the architecture, chemical neuroanatomy, and topological relationships of the component parts of the hippocampal formation of the tree pangolin were consistent with that observed in other mammalian species. Within the hippocampus proper fields CA1, 3, and 4 could be identified with certainty, while CA2 was tentatively identified as a small transitional zone between the CA1 and CA3 fields. Read More

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http://dx.doi.org/10.1002/cne.24620DOI Listing
December 2018
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Characterization of perinatally born glutamatergic neurons of the mouse olfactory bulb based on NeuroD6 expression reveals their resistance to sensory deprivation.

J Comp Neurol 2018 Dec 27. Epub 2018 Dec 27.

Aix Marseille Univ, CNRS UMR 7288, Developmental Biology Institute of Marseille (IBDM), Parc scientifique de Luminy, Marseille, France.

During postnatal olfactory bulb (OB) neurogenesis, predetermined stem cells residing in the ventricular-subventricular zone continuously generate progenitors that migrate in the rostral migratory stream and integrate into the OB. Although the vast majority of these postnatally generated interneurons are inhibitory, a sub-fraction represents glutamatergic neurons that integrate into the superficial glomerular layer. In the present work, we demonstrate that the bHLH transcription factor NeuroD6 is specifically and transitorily expressed in the dorsal neurogenic lineage that generates glutamatergic juxtaglomerular cells (JGCs) for the OB. Read More

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http://dx.doi.org/10.1002/cne.24621DOI Listing
December 2018

Differential investment in brain regions for a diurnal and nocturnal lifestyle in Australian Myrmecia ants.

J Comp Neurol 2018 Dec 27. Epub 2018 Dec 27.

Department of Biological Sciences, Macquarie University, Sydney, New South Wales, Australia.

Animals are active at different times of the day. Each temporal niche offers a unique light environment, which affects the quality of the available visual information. To access reliable visual signals in dim-light environments, insects have evolved several visual adaptations to enhance their optical sensitivity. Read More

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http://dx.doi.org/10.1002/cne.24617DOI Listing
December 2018
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Astrocytic changes with aging and Alzheimer's disease-type pathology in chimpanzees.

J Comp Neurol 2018 Dec 22. Epub 2018 Dec 22.

Department of Anthropology and School of Biomedical Sciences, Kent State University, Kent, Ohio.

Astrocytes are the main homeostatic cell of the central nervous system. In addition, astrocytes mediate an inflammatory response when reactive to injury or disease known as astrogliosis. Astrogliosis is marked by an increased expression of glial fibrillary acidic protein (GFAP) and cellular hypertrophy. Read More

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http://dx.doi.org/10.1002/cne.24610DOI Listing
December 2018
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Primate neocortex development and evolution: Conserved versus evolved folding.

J Comp Neurol 2018 Dec 15. Epub 2018 Dec 15.

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

The neocortex, the seat of higher cognitive functions, exhibits a key feature across mammalian species-a highly variable degree of folding. Within the neocortex, two distinct subtypes of cortical areas can be distinguished, the isocortex and the proisocortex. Here, we have compared specific spatiotemporal aspects of folding between the proisocortex and the isocortex in 13 primates, including human, chimpanzee, and various Old World and New World monkeys. Read More

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http://dx.doi.org/10.1002/cne.24606DOI Listing
December 2018
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Unraveling the functional organization of lobula complex in the mantis brain by identification of visual interneurons.

J Comp Neurol 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan.

The praying mantis shows broad repertories of visually guided behaviors such as prey recognition and defense against collision. It is likely that neurons in the lobula complex (LOX), the third visual neuropil in the optic lobe, play significant roles in these behaviors. The LOX in the mantis brain consists of five neuropils: outer lobes 1 and 2 (OLO1 and OLO2); anterior lobe (ALO); dorsal lobe (DLO); and stalk lobe (SLO), and ALO comprise ventral and dorsal subunits, ALO-V and ALO-D. Read More

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http://dx.doi.org/10.1002/cne.24603DOI Listing
December 2018