5,378 results match your criteria Journal of Clinical Periodontology [Journal]


An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis.

J Clin Periodontol 2018 Dec 17. Epub 2018 Dec 17.

Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, Massachusetts, USA.

Background: Historically, inflammatory periodontal diseases (gingivitis and periodontitis) have been recognized as being primarily of bacterial origin. Bacteria are necessary for disease development, but the presence of specific bacteria does not guarantee progression to periodontitis. Periodontitis is a multifactorial disease; specific bacteria are associated with disease, but may not be the target of treatment. Read More

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http://dx.doi.org/10.1111/jcpe.13046DOI Listing
December 2018

In Memoriam, Steven Offenbacher (1950-2018).

J Clin Periodontol 2018 Dec 7. Epub 2018 Dec 7.

University of Athens, Periodontology, Thivon 2, Goudi, Athens, Greece.

I first met Steven Offenbacher in the fall of 1977 when he interviewed for the postdoctoral training program in periodontology at Harvard. He was bright, witty and inquisitive and clearly a terrific applicant to the program. Over the next three years Steven trained at Harvard in periodontics and at Forsyth in pharmacology, graduating in 1980. Read More

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http://dx.doi.org/10.1111/jcpe.13043DOI Listing
December 2018

Genetic and environmental contributions to the association between mood disorder and periodontal disease: a cross-sectional study amongst female twins in the UK.

J Clin Periodontol 2018 Dec 8. Epub 2018 Dec 8.

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.

Aim: This study aimed to investigate the factors associated with periodontal traits considering genetic and environmental background in predominantly older female twins.

Methods: This was a cross-sectional study using self-reported questionnaires for periodontal traits in TwinsUK. Age-adjusted and age-stratified multivariate analyses were conducted for all twins. Read More

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http://dx.doi.org/10.1111/jcpe.13045DOI Listing
December 2018

Impact of Diabetes on Clinical Periodontal Outcomes Following Non-Surgical Periodontal Therapy.

J Clin Periodontol 2018 Dec 8. Epub 2018 Dec 8.

Department of Periodontics and Dental Hygiene, University of Texas Health Science Center at Houston, Houston, TX.

Aim: This systematic review aimed to evaluate the impact of diabetes mellitus on clinical outcomes of non-surgical periodontal therapy.

Materials And Methods: Searches were conducted in electronic databases to screen studies published from January 1960 to August 2018. The included studies had at least two groups of patients: chronic periodontitis only (P) or both diabetes and chronic periodontitis (DMP). Read More

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http://dx.doi.org/10.1111/jcpe.13044DOI Listing
December 2018

Dysregulation of human miRNAs and increased prevalence of HHV miRNAs in obese periodontitis subjects.

J Clin Periodontol 2018 Nov 30. Epub 2018 Nov 30.

Department of Periodontics, University of Illinois at Chicago, Chicago, IL, USA.

Aim: To evaluate human and herpesvirus-encoded microRNA (miRNA) expression in healthy and diseased gingiva of obese and non-obese subjects and compare the impact of localized and systemic inflammation on human miRNA profiles.

Material And Methods: Healthy and inflamed gingival biopsies were collected from obese and non-obese subjects. Human and herpesvirus miRNA expression was quantified using quantitative PCR. Read More

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http://dx.doi.org/10.1111/jcpe.13040DOI Listing
November 2018
2 Reads

Is there an association between depression and periodontitis? A birth cohort study.

J Clin Periodontol 2018 Nov 30. Epub 2018 Nov 30.

Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.

Aim: To investigate the association between depression and periodontitis among adults enrolled in the 1982 Pelotas Birth Cohort, Brazil.

Materials And Methods: Major depressive episode and severity of depressive symptoms obtained in 2012 were considered the exposure of this study. In 2013, periodontitis, the outcome of interest, was clinically assessed and two different case definitions were used: the CDC/AAP and a combination of CAL and BOP simultaneously. Read More

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http://dx.doi.org/10.1111/jcpe.13039DOI Listing
November 2018
2 Reads

Time between recall visits and residual probing depths predict long-term stability in patients enrolled in supportive periodontal therapy.

J Clin Periodontol 2018 Nov 30. Epub 2018 Nov 30.

Department of Periodontology, School of Dental Medicine, University of Bern, Switzerland.

Aim: To relate the time between recall visits and residual periodontal probing depths (PPD) to periodontal stability in patients enrolled in supportive periodontal therapy (SPT).

Materials And Methods: Retrospective data on residual PPDs from 11'842 SPT visits were evaluated in SPT patients at the Medi School of Dental Hygiene (MSDH), Bern, Switzerland 1985-2011. A residual PPD-based algorithm was developed to compute SPT-intervals with no expected change of residual PPD. Read More

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http://dx.doi.org/10.1111/jcpe.13041DOI Listing
November 2018

Prediction models for the incidence and progression of periodontitis: A systematic review.

J Clin Periodontol 2018 Dec 25;45(12):1408-1420. Epub 2018 Nov 25.

Australian Research Centre for Population Oral Health, the University of Adelaide, Adelaide, South Australia, Australia.

Aims: To comprehensively review, identify and critically assess the performance of models predicting the incidence and progression of periodontitis.

Methods: Electronic searches of the MEDLINE via PubMed, EMBASE, DOSS, Web of Science, Scopus and ProQuest databases, and hand searching of reference lists and citations were conducted. No date or language restrictions were used. Read More

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http://doi.wiley.com/10.1111/jcpe.13037
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http://dx.doi.org/10.1111/jcpe.13037DOI Listing
December 2018
12 Reads

Healing kinetics of oral soft tissue wounds treated with recombinant epidermal growth factor: Translation from a canine model.

J Clin Periodontol 2018 Oct 29. Epub 2018 Oct 29.

Department of Periodontology and Dental Research Institute, Translational Research Laboratory for Tissue Engineering (TTE), School of Dentistry, Seoul National University, Seoul, Korea.

Objective: To test whether or not topically administered recombinant human epidermal growth factor (rhEGF) accelerates the early healing phase of oral soft tissue wounds.

Methods: One day following the creation of palatal defects (n = 6/animal), 14 dogs were allocated to one of the following five groups: spontaneous healing (SH), vehicle ointment (V), vehicle ointment + rhEGF at concentrations of 1 μg/g (EGF1), 10 μg/g (EGF10) or 50 μg/g (EGF50). Topical administration of ointments was repeated twice per day until sacrifice at days 8 and 16. Read More

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http://doi.wiley.com/10.1111/jcpe.13035
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http://dx.doi.org/10.1111/jcpe.13035DOI Listing
October 2018
19 Reads

Soft tissue substitutes to increase gingival thickness: Histologic and volumetric analyses in dogs.

J Clin Periodontol 2018 Oct 29. Epub 2018 Oct 29.

Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.

Objectives: To evaluate the histologic and volumetric changes of gingival tissues following grafting with collagen-based matrices at labial aspect of teeth in canines.

Materials And Methods: Gingival augmentation was performed in the mandibular incisor area using two types of xenogeneic cross-linked collagen matrices (CCMs), bovine CCM for BCCM group and porcine CCM for PCCM group, whereas the contralateral sides remained untreated (B-control group and P-control group). Descriptive histology, histometric and volumetric analyses were performed after 12 weeks. Read More

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http://doi.wiley.com/10.1111/jcpe.13034
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http://dx.doi.org/10.1111/jcpe.13034DOI Listing
October 2018
5 Reads

Nupharidine enhances Aggregatibacter actinomycetemcomitans clearance by priming neutrophils and augmenting their effector functions.

J Clin Periodontol 2018 Oct 29. Epub 2018 Oct 29.

Department of Periodontology, The Hebrew University-Hadassah Medical Center, Jerusalem, Israel.

Objectives: Nupharidine (6,6'-Dihydroxythiobinupharidine), purified from the aquatic plant Nuphar lutea leaves (Water lily) prompts antimicrobial activity of immune cells. The aim of the study was to test the effect of Nupharidine on neutrophil function against Aggregatibacter actinomycetemcomitans, JP2 clone (Aa-JP2).

Methods: Neutrophils derived from the human cell line HL60 and human peripheral blood derived from aggressive periodontitis and periodontally healthy subjects were incubated with Nupharidine or vehicle and inoculated with JP2. Read More

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http://doi.wiley.com/10.1111/jcpe.13036
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http://dx.doi.org/10.1111/jcpe.13036DOI Listing
October 2018
5 Reads

Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct.

J Clin Periodontol 2018 Oct 26. Epub 2018 Oct 26.

Periodontology Unit, Faculty of Medicine and Odontology, Medical-Surgical Dentistry (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.

Aim: To investigate the association between periodontitis (PD) and lacunar infarct (LI) as well as to analyse whether PD could be a predictor of poor functional prognosis in patients with LI.

Material And Methods: Full-mouth periodontal examination was done in 120 cases (patients with LI) and 157 healthy controls. Demographic, clinical, medical and neurological information were collected from all of them. Read More

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http://dx.doi.org/10.1111/jcpe.13032DOI Listing
October 2018
3 Reads

Periodontal disease and incident venous thromboembolism: The Atherosclerosis Risk in Communities study.

J Clin Periodontol 2018 Oct 26. Epub 2018 Oct 26.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota.

Aim: Periodontal disease is a cardiovascular disease (CVD) risk factor but few studies have considered the relationship between periodontal disease and venous thromboembolism (VTE). We hypothesized that periodontal disease is independently associated with increased risk of incident VTE.

Materials And Methods: We used data from 8,092 participants of the Atherosclerosis Risk in Communities (ARIC) study to examine periodontal disease in 1996-1998 and incident VTE through 2011. Read More

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http://doi.wiley.com/10.1111/jcpe.13029
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http://dx.doi.org/10.1111/jcpe.13029DOI Listing
October 2018
2 Reads

Dietary therapy and non-surgical periodontal treatment in obese patients with chronic periodontitis.

J Clin Periodontol 2018 Dec 25;45(12):1448-1457. Epub 2018 Nov 25.

Service of Endocrinology and Nutrition, University Hospital Doctor Peset-FISABIO, Valencia, Spain.

Aim: The effect of dietary weight loss intervention on periodontal therapy is unknown. Therefore, we aimed to evaluate whether weight loss improves the response of obese subjects to non-surgical periodontal treatment.

Materials And Methods: This interventional study in obese patients was conducted at the University Hospital Dr. Read More

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http://dx.doi.org/10.1111/jcpe.13030DOI Listing
December 2018

Clinical evaluation of Miller class I and II recessions treatment with the use of modified coronally advanced tunnel technique with either collagen matrix or subepithelial connective tissue graft: A randomized clinical study.

J Clin Periodontol 2018 Oct 26. Epub 2018 Oct 26.

Dental Practice, Białystok, Poland.

Aim: To compare outcomes of modified coronally advanced tunnel technique (MCAT) combined with either collagen matrix (CM) or subepithelial connective tissue graft (SCTG) in the treatment of Miller class I and II multiple gingival recessions in the mandible.

Materials And Methods: The study encompassed 91 recessions in 29 patients for whom MCAT was combined with CM on one side of the mandible and SCTG on the contralateral one. The following clinical parameters were measured: gingival recession height (GR) and width (RW), probing depth (PD), clinical attachment level (CAL), width of keratinized tissue (KT), gingival thickness (GT), mean (MRC) and complete root coverage (CRC) and Root Coverage Esthetic Score (RES). Read More

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http://doi.wiley.com/10.1111/jcpe.13031
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http://dx.doi.org/10.1111/jcpe.13031DOI Listing
October 2018
7 Reads

Chronic periodontitis impairs polymorphonuclear leucocyte-endothelium cell interactions and oxidative stress in humans.

J Clin Periodontol 2018 Dec 20;45(12):1429-1439. Epub 2018 Nov 20.

Service of Endocrinology and Nutrition, University Hospital Doctor Peset-FISABIO, Valencia, Spain.

Aim: To evaluate the relationship between oxidative stress parameters in polymorphonuclear leucocytes (PMNs) and PMN-endothelial cell interactions in patients with chronic periodontitis (CP) according to different degrees of severity of the disease.

Materials And Methods: For this cross-sectional study, 182 subjects were divided into four groups according to degree of CP: without CP (n = 37), mild CP (n = 59), moderate CP (n = 51), and severe CP (n = 35). We determined anthropometric and biochemical variables, periodontal parameters, inflammatory markers, oxidative stress parameters (superoxide and mitochondrial membrane potential), and PMN-endothelium cell interactions (rolling flux, velocity, and adhesion). Read More

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http://doi.wiley.com/10.1111/jcpe.13027
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http://dx.doi.org/10.1111/jcpe.13027DOI Listing
December 2018
2 Reads

Meta-analysis of randomized clinical trials comparing clinical and patient-reported outcomes between extra-short (≤6 mm) and longer (≥10 mm) implants.

J Clin Periodontol 2018 Oct 25. Epub 2018 Oct 25.

Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan.

Aim: To compare the clinical outcomes of ≤6 mm extra-short implants (test group) versus ≥10 mm long implants (control group), with and without bone augmentation procedures.

Materials And Methods: A systemic literature search of randomized clinical trials was performed using the PubMed (MEDLINE) and EMBASE databases. A quantitative meta-analysis was conducted to compare all the outcome variables. Read More

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http://doi.wiley.com/10.1111/jcpe.13026
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http://dx.doi.org/10.1111/jcpe.13026DOI Listing
October 2018
3 Reads
4.010 Impact Factor

How do visual-spatial and psychomotor abilities influence clinical performance in periodontal plastic surgery?

J Clin Periodontol 2018 Oct 25. Epub 2018 Oct 25.

Prince Philip Dental Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR.

Aim: We want to evaluate the relationship of self-assessed experience and proficiency, manual dexterity and visual-spatial ability with surgical performance.

Material And Methods: A total of 26 professionals were included in the study which consisted of four parts: (a) self-assessment by a questionnaire regarding proficiency and experience, (b) evaluation of visual-spatial ability, (c) testing of manual dexterity assessed by validated psychomotor tests and (d) evaluation of surgical performance by Objective Structured Assessment of Technical Skills (OSATS).

Results: Self-assessed proficiency and experience levels did not correlate with objectively evaluated surgical performances (OSATS). Read More

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http://doi.wiley.com/10.1111/jcpe.13028
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http://dx.doi.org/10.1111/jcpe.13028DOI Listing
October 2018
8 Reads

The severity of human peri-implantitis lesions correlates with the level of submucosal microbial dysbiosis.

J Clin Periodontol 2018 Dec 19;45(12):1498-1509. Epub 2018 Nov 19.

Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.

Aim: To cross-sectionally analyse the submucosal microbiome of peri-implantitis (PI) lesions at different severity levels.

Materials And Methods: Microbial signatures of 45 submucosal plaque samples from untreated PI lesions obtained from 30 non-smoking, systemically healthy subjects were assessed by 16s sequencing. Linear mixed models were used to identify taxa with differential abundance by probing depth, after correction for age, gender, and multiple samples per subject. Read More

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http://dx.doi.org/10.1111/jcpe.13023DOI Listing
December 2018

Association between periodontal health status and patient-reported outcomes in patients managed in a non-specialist, general dental practice.

J Clin Periodontol 2018 Dec 5;45(12):1440-1447. Epub 2018 Nov 5.

School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Aims: To explore the associations between periodontal status and patient-reported outcomes (PROs) in a large cohort of patients based in non-specialist general dental practice.

Materials And Methods: Analysis was conducted using data from 14,620 patients, in 233 non-specialist dental practices across the UK. As part of routine clinical care, data on periodontal probing depths (PPD), alveolar bone loss (ABL), bleeding on probing (BoP) as well as PROs (oral pain/discomfort, dietary restrictions and dental appearance) were recorded using an online database. Read More

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http://doi.wiley.com/10.1111/jcpe.13022
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http://dx.doi.org/10.1111/jcpe.13022DOI Listing
December 2018
3 Reads

Randomized controlled multicentre study comparing short dental implants (6 mm) versus longer dental implants (11-15 mm) in combination with sinus floor elevation procedures: 5-Year data.

J Clin Periodontol 2018 Dec 25;45(12):1465-1474. Epub 2018 Nov 25.

Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.

Aim: To compare the implant survival rate between short dental implants and standard length implants placed in combination with bone grafting at 5 years of loading.

Methods: This multicentre study enrolled 101 patients (137 implants) with a posterior maxillary bone height of 5-7 mm. Patients randomly received either short implants (6 mm; GS) or long implants (11-15 mm) with sinus grafting (GG). Read More

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http://doi.wiley.com/10.1111/jcpe.13025
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http://dx.doi.org/10.1111/jcpe.13025DOI Listing
December 2018
7 Reads

Molecular forms and fragments of salivary MMP-8 in relation to periodontitis.

J Clin Periodontol 2018 Dec 18;45(12):1421-1428. Epub 2018 Nov 18.

Department of Oral and Maxillofacial Disease, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Aim: To investigate the molecular forms of salivary matrix metalloproteinase (MMP)-8 in relation to periodontitis.

Materials And Methods: Molecular forms, degree of activation and fragmentation of neutrophilic and mesenchymal-type MMP-8 isoforms were analysed from salivary samples of 81 subjects with generalized periodontitis, 63 subjects with localized periodontitis and 79 subjects without pocket teeth, by using western-immunoblots with computer quantitation. In addition, human recombinant proMMP-8 was in vitro activated by Treponema denticola chymotrypsin-like protease (Td-CTLP), sodium hypochlorite (NaOCl, 1 mM, oxidant) or amino phenyl mercuric acetate (APMA, 1 mM). Read More

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http://doi.wiley.com/10.1111/jcpe.13024
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http://dx.doi.org/10.1111/jcpe.13024DOI Listing
December 2018
5 Reads

Long-term stability of intrabony defects treated with minimally invasive non-surgical therapy.

J Clin Periodontol 2018 Dec 5;45(12):1458-1464. Epub 2018 Nov 5.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Aim: The aim of this study was to assess the stability over time of periodontal intrabony defects treated with minimally invasive non-surgical therapy (MINST) and supportive periodontal therapy (SPT).

Methods: Clinical and radiographic analysis was carried out in 21 intrabony defects treated with MINST in 14 consecutive patients included in a prospective study and reassessed after 5 years of SPT. Baseline, 1- and 5-year radiographs were analysed, and bone levels were compared by multilevel linear regression adjusted by latent variable method. Read More

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http://dx.doi.org/10.1111/jcpe.13021DOI Listing
December 2018

More teeth in more elderly: Periodontal treatment needs in Germany 1997-2030.

J Clin Periodontol 2018 Dec 20;45(12):1400-1407. Epub 2018 Nov 20.

Institute of German Dentists (IDZ), Cologne, Germany.

Objective: With more teeth retained for longer in an ageing population, population-wide periodontal treatment needs may increase. We assessed and projected periodontal treatment needs from 1997 to 2030 in Germany.

Methods: Partial-mouth probing-pocket depths (PPDs) from repeated waves (1997, 2005, 2014) of the nationally representative German Oral Health Studies were transformed into full-mouth PPDs via decision-tree-based ensemble-modelling. Read More

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http://dx.doi.org/10.1111/jcpe.13020DOI Listing
December 2018

A 5-year prospective study on the clinical and aesthetic outcomes of alveolar ridge preservation and connective tissue graft at the buccal aspect of single implants.

J Clin Periodontol 2018 Dec 5;45(12):1475-1484. Epub 2018 Nov 5.

Faculty of Medicine and Pharmacy, Oral Health Research Group (ORHE), Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Aim: To evaluate the 5-year aesthetic outcome of single implants following alveolar ridge preservation (ARP) and connective tissue graft (CTG) at the buccal aspect.

Materials And Methods: Thirty-seven periodontally healthy non-smoking patients received flapless tooth extraction, ARP with a deproteinized bovine bone mineral with 10% collagen (DBBMC), implant placement (4-6 months later), a provisional screw-retained crown and CTG at the buccal mucosa (3 months later) and a permanent crown (3 months later). The aesthetic results were the primary outcome and the clinical results the secondary outcome of the study. Read More

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http://doi.wiley.com/10.1111/jcpe.13018
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http://dx.doi.org/10.1111/jcpe.13018DOI Listing
December 2018
4 Reads

Association between periodontitis and risk of Alzheimer's disease, mild cognitive impairment and subjective cognitive decline: A case-control study.

J Clin Periodontol 2018 Nov;45(11):1287-1298

Department of Dental Medicine, Division of Oral Diseases, Karolinska Institutet, Huddinge, Sweden.

Aims: To test the hypothesis that periodontal disease contributes to increased risk of mild cognitive impairment (MCI), subjective cognitive decline (SCD) and Alzheimer's disease (AD).

Materials And Methods: This case-control study was conducted over a 3-year period in the municipality of Huddinge, Sweden. In total, 154 cases were consecutively enrolled from the Karolinska Memory Clinic at the Karolinska University Hospital and allotted to three diagnostic groups: AD, MCI and SCD, collectively referred to as "cases. Read More

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http://dx.doi.org/10.1111/jcpe.13016DOI Listing
November 2018

The antidepressant drug, sertraline, hinders bone healing and osseointegration in rats' tibiae.

J Clin Periodontol 2018 Dec 5;45(12):1485-1497. Epub 2018 Nov 5.

Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.

Aim: Selective serotonin reuptake inhibitors (SSRIs) are one of the most common antidepressant drugs. SSRI use is associated with increased risk of bone fracture and titanium implant failure. The aim of this in vivo study was to investigate the effect of SSRIs on osseointegration and bone healing. Read More

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http://dx.doi.org/10.1111/jcpe.13015DOI Listing
December 2018
7 Reads

Prevalence and risk indicators of peri-implant diseases in Spain.

J Clin Periodontol 2018 Dec 5;45(12):1510-1520. Epub 2018 Nov 5.

ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain.

Aim: To evaluate the prevalence of peri-implant diseases in Spain, as well as the associated risk indicators.

Material And Methods: This is a cross-sectional study using a network of sentinel dentists, who randomly selected 10 patients with implants (placed, at least, 5 years before), which were clinically and radiographically evaluated. Case definitions were established for peri-implant mucositis [bleeding on probing (BOP) and no bone level ≥2 mm] and peri-implantitis (BOP plus bone level ≥2 mm). Read More

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http://doi.wiley.com/10.1111/jcpe.13017
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http://dx.doi.org/10.1111/jcpe.13017DOI Listing
December 2018
1 Read

Radiographic and histologic observations of sequential healing processes following ridge augmentation after tooth extraction in buccal-bone-deficient extraction sockets in beagle dogs.

J Clin Periodontol 2018 Nov 23;45(11):1388-1397. Epub 2018 Oct 23.

Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, South Korea.

Objectives: To evaluate dimensional ridge alterations and sequential healing processes following ridge augmentation after tooth extraction in damaged extraction sockets with buccal-bone-deficiency.

Material And Methods: Bilateral dental roots of three mandibular premolars were extracted with entire removal of the buccal-bone plate in eight beagle dogs. Unilateral sites were grafted with biomaterials (test group) and contralateral sites were healed without grafting (control group). Read More

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http://dx.doi.org/10.1111/jcpe.13014DOI Listing
November 2018
3 Reads

Melatonin as adjunctive therapy in the treatment of periodontitis associated with obesity.

J Clin Periodontol 2018 Nov 23;45(11):1336-1346. Epub 2018 Oct 23.

Etiology and Therapy of Periodontal Diseases (ETEP) Research Group, University Complutense, Madrid, Spain.

Aims: To study the effect of adjunctive systemic administration of melatonin to standard mechanical periodontal therapy in obese rats with experimental periodontitis.

Materials And Methods: In 42 Wistar rats with an initial body weight of 180 g., half (n = 21) were fed with a high-fat diet to induce obesity. Read More

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http://dx.doi.org/10.1111/jcpe.13013DOI Listing
November 2018
4 Reads

A new method of choice for organoleptic scoring: The negative-pressure technique.

J Clin Periodontol 2018 Nov 12;45(11):1319-1325. Epub 2018 Oct 12.

Section of Periodontology, Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.

Aim: To examine an organoleptic scoring method (OLS) whereby the sample is collected by negative pressure in a syringe and is subsequently smelled and rated away from the patient.

Materials And Methods: Data of 476 patients visiting a specialized halitosis clinic in Leuven (Belgium) were reviewed retrospectively. Organoleptic (with the classic and with the negative-pressure method) and instrumental (with the Halimeter® and OralChroma ) ratings of breath odour were retrieved from patient files together with the final diagnosis. Read More

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http://doi.wiley.com/10.1111/jcpe.13012
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http://dx.doi.org/10.1111/jcpe.13012DOI Listing
November 2018
9 Reads

Oral health-related quality of life and standard of treatment in aggressive periodontitis patients more than 5 years after therapy.

J Clin Periodontol 2018 Nov 21;45(11):1347-1355. Epub 2018 Oct 21.

Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental and Maxillofacial Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Objectives: To assess OHRQoL in patients with aggressive periodontitis (AgP) after periodontal treatment using the Oral Health Impact Profile-49 (OHIP-49) and compare to patients' dental status.

Material And Methods: More than 5 years after therapy, 71 patients were examined and answered the OHIP-questionnaire. The dental and periodontal status were assessed according to the SSO (Swiss Dental Society) criteria. Read More

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http://dx.doi.org/10.1111/jcpe.13011DOI Listing
November 2018
1 Read

Tooth loss in periodontally compromised patients: Results 20 years after active periodontal therapy.

J Clin Periodontol 2018 Nov 23;45(11):1356-1364. Epub 2018 Oct 23.

Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental and Maxillofacial Diseases, University Hospital Heidelberg, Heidelberg, Germany.

Aim: To assess tooth loss in periodontally compromised patients 20 years after active periodontal therapy (APT) and to detect potential influencing factors for tooth loss on patient level.

Material And Methods: From a total of 100 patients, who were re-evaluated ten years after APT, 70 could be re-examined 20 years ± 12 months after APT. Tooth loss during 20 years was detected and based on regression analyses the impact of patient-levelled factors was estimated. Read More

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http://doi.wiley.com/10.1111/jcpe.13010
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http://dx.doi.org/10.1111/jcpe.13010DOI Listing
November 2018
5 Reads

Third molars and periodontal damage of second molars in the general population.

J Clin Periodontol 2018 Nov 22;45(11):1365-1374. Epub 2018 Oct 22.

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

Aim: The aim of this study was to clarify the association between impacted or erupted third molars and periodontal pathology, assessed by probing depth (PD) and clinical attachment levels (CAL), in adjacent second molars.

Materials And Methods: Data from the population-based Study of Health in Pomerania (SHIP) was used. This is the first project with whole-body magnetic resonance imaging (WB-MRI) application in a general population setting with dental issues. Read More

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http://doi.wiley.com/10.1111/jcpe.13008
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http://dx.doi.org/10.1111/jcpe.13008DOI Listing
November 2018
12 Reads

The effects of periodontal treatment on diabetic patients: The DIAPERIO randomized controlled trial.

J Clin Periodontol 2018 Oct 14;45(10):1150-1163. Epub 2018 Sep 14.

The Department of Oral Rehabilitation, Faculty of Dentistry, Toulouse University Hospital (CHU de Toulouse), Paul Sabatier University, Toulouse, France.

Aim: To assess whether periodontal treatment can lead to clinical, glycaemic control and quality of life improvements in metabolically unbalanced diabetic patients (type 1 or type 2) diagnosed with periodontitis.

Methods: In this open-labelled randomized controlled trial, diabetic subjects (n = 91) were given "immediate" or "delayed" periodontal treatment (full-mouth non-surgical scaling and root planing, systemic antibiotics, and oral health instructions). The main outcome was the effect on glycated haemoglobin (HbA ) and fructosamine levels. Read More

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http://dx.doi.org/10.1111/jcpe.13003DOI Listing
October 2018
4 Reads

Association between periodontal condition and the development of type 2 diabetes mellitus-Results from a 15-year follow-up study.

J Clin Periodontol 2018 Nov 21;45(11):1276-1286. Epub 2018 Oct 21.

Research Unit of Oral Health Sciences, University of Oulu, Oulu, Finland.

Aim: To study whether periodontal condition is associated with the development of type 2 diabetes mellitus (T2DM).

Materials And Methods: A population-based follow-up study was conducted among persons born in 1935 and living in the city of Oulu, Finland (n = 395). The baseline examinations were done during 1990-1992, and the follow-up examinations were done during 2007-2008. Read More

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http://dx.doi.org/10.1111/jcpe.13005DOI Listing
November 2018
2 Reads

Periodontitis and platelet count: A new potential link with cardiovascular and other systemic inflammatory diseases.

J Clin Periodontol 2018 Nov;45(11):1299-1310

Institute of Dentistry and Maxillofacial Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy.

Aim: As an infection-driven inflammatory disease, periodontitis could lead to a reactive increase in platelet count. This mechanism could partially mediate the well-documented association between periodontitis and atherosclerotic cardiovascular disease. The aim of this cross-sectional study was to test the presence of an association between periodontitis and platelet count in a representative sample of the South Korea population. Read More

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http://doi.wiley.com/10.1111/jcpe.13004
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http://dx.doi.org/10.1111/jcpe.13004DOI Listing
November 2018
8 Reads

A randomized controlled study comparing guided bone regeneration with connective tissue graft to re-establish convexity at the buccal aspect of single implants: A one-year CBCT analysis.

J Clin Periodontol 2018 Nov;45(11):1375-1387

Vrije Universiteit Brussel (VUB), Faculty of Medicine and Pharmacy, Oral Health Research Group (ORHE), Brussels, Belgium.

Aim: To compare guided bone regeneration (GBR) with connective tissue graft (CTG) to re-establish convexity at the buccal aspect of single implants.

Materials And Methods: Patients with a single tooth gap in the anterior maxilla and horizontal alveolar defect were enrolled in a single-blind randomized controlled trial. Sites had to demonstrate buccopalatal bone dimension of at least 6 mm prior to surgery to ensure complete embedding of an implant without the need for bone augmentation. Read More

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http://dx.doi.org/10.1111/jcpe.13006DOI Listing
November 2018
1 Read

Controlled cellular redox, repressive hemin utilization and adaptive stress responses are crucial to metronidazole tolerance of Porphyromonas gingivalis persisters.

J Clin Periodontol 2018 Oct 1;45(10):1211-1221. Epub 2018 Oct 1.

Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.

Background: Antimicrobial-tolerant microbial persisters critically account for various infections and inflammation. This study identified the characteristics of Porphyromonas gingivalis persisters, and explored their underlying survival mechanisms through proteomic profiling.

Methods: Porphyromonas gingivalis cultured with different concentrations of hemin was treated with 100 μg/ml of metronidazole (MTZ). Read More

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http://doi.wiley.com/10.1111/jcpe.13002
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http://dx.doi.org/10.1111/jcpe.13002DOI Listing
October 2018
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Development and validation of the periodontal aesthetic perception scale in patients with periodontal problems.

J Clin Periodontol 2018 Oct 1;45(10):1247-1254. Epub 2018 Oct 1.

Department of Educational Measurement and Evaluation, Faculty of Education, Gaziosmanpasa University, Tokat, Turkey.

Aim: The aim of this study was to develop and validate a periodontal aesthetic-specific tool to assess aesthetic conditions perceived by patients with periodontal problems.

Materials And Methods: Hundred patients were interviewed that described the nonaesthetic gingival appearance. An item pool with 22 items was generated. Read More

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http://dx.doi.org/10.1111/jcpe.13000DOI Listing
October 2018
2 Reads

Evaluation of peri-implant marginal tissues around tissue-level and bone-level implants in patients with a history of chronic periodontitis.

J Clin Periodontol 2018 Oct;45(10):1255-1265

Division of Periodontics, Piracicaba Dental School/State University of Campinas, Piracicaba, São Paulo, Brazil.

Objective: To evaluate clinical and radiographic characteristics in peri-implant marginal tissues in patients with a history of chronic periodontitis, rehabilitated using tissue-level or bone-level implants.

Material And Methods: Using a split-mouth design, 20 patients with a history of chronic periodontitis were selected and received two different implants, tissue-level group (n = 20) and the bone-level group (n = 20). Peri-implant probing depth, relative peri-implant mucosal margin position, relative peri-implant clinical attachment level, peri-implant plaque index and peri-implant bleeding on probing were evaluated at prosthesis installation, 1, 3, 6, 12 and 24 months after implant loading. Read More

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http://dx.doi.org/10.1111/jcpe.12999DOI Listing
October 2018
2 Reads

Self-reported oral health predicts tooth loss after five and ten years in a population-based study.

J Clin Periodontol 2018 Oct 6;45(10):1164-1172. Epub 2018 Sep 6.

Dental School, University of Greifswald, Greifswald, Germany.

Aim: To assess the suitability of self-reported oral health status to predict 5- and 10-year tooth loss without involvement of any clinical measures.

Materials And Methods: Within the population Study of Health in Pomerania (SHIP), 2,776 subjects with 5-year follow-up data and 2,016 subjects with 10-year follow-up examination data were studied. Self-rated oral health was assessed at baseline and related to 5- and 10-year tooth loss. Read More

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http://dx.doi.org/10.1111/jcpe.12997DOI Listing
October 2018

Biologically guided flap stability: the role of flap thickness including periosteum retention on the performance of the coronally advanced flap-A double-blind randomized clinical trial.

J Clin Periodontol 2018 Oct 14;45(10):1238-1246. Epub 2018 Sep 14.

Department of Periodontology, Università Vita-Salute San Raffaele, Milan, Italy.

Aim: To evaluate the possible benefit on wound healing and flap stability of periosteum inclusion, comparing a "split-full-split" thickness flap elevation versus a "split" thickness approach performed during CAF for the treatment of isolated-type gingival recessions in the upper jaw.

Material And Methods: Forty patients were randomized, 20 were treated with "split-full-split" (test group) and 20 with a "split" approach (control group). Analysed parameters at 1 year were CRC, percentage of recession coverage (RC), keratinized tissue (KT) gain and patient-related outcome measurements. Read More

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http://dx.doi.org/10.1111/jcpe.12998DOI Listing
October 2018
8 Reads

Longitudinal evaluation of periodontitis and development of cognitive decline among older adults.

J Clin Periodontol 2018 Oct 22;45(10):1142-1149. Epub 2018 Aug 22.

Blekinge Institute of Technology, Karlskrona, Sweden.

Aim: To determine whether having periodontitis is associated with cognitive decline among older adults.

Material And Methods: A prospective population study of older adults, Swedish National Study on Ageing and Care, (SNAC) provided repeated registrations of cognitive functions. Cognitive decline was defined as ≥3-points deterioration from a predetermined level at baseline, using the Mini-Mental State Examination (MMSE). Read More

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http://dx.doi.org/10.1111/jcpe.12992DOI Listing
October 2018
11 Reads

The effect of periodontal therapy on oxidative stress biomarkers: A systematic review.

J Clin Periodontol 2018 Oct 28;45(10):1222-1237. Epub 2018 Aug 28.

Department of Periodontology, Federal University Rio Grande do Sul, Porto Alegre, Brazil.

Aim: To systematically review the literature about the effect of periodontal treatment on oxidative stress (OxS) biomarkers.

Material And Methods: Three databases (PubMed, EMBASE, and Scopus) were searched up to February 2018. Clinical trials with a follow-up of at least 6 weeks after mechanical periodontal treatment were included. Read More

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http://dx.doi.org/10.1111/jcpe.12993DOI Listing
October 2018
1 Read

Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study.

J Clin Periodontol 2018 Nov 21;45(11):1326-1335. Epub 2018 Oct 21.

Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.

Aim: To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX).

Material And Methods: Diabetic and nondiabetic subjects with severe periodontitis received SRP + MTZ (400 mg/thrice a day [TID]) + AMX (500 mg/TID) for 14 days. Subgingival biofilm samples were analyzed by checkerboard DNA-DNA hybridization for 40 bacterial species. Read More

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http://dx.doi.org/10.1111/jcpe.12994DOI Listing
November 2018
1 Read

Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial.

J Clin Periodontol 2018 Oct 24;45(10):1198-1210. Epub 2018 Sep 24.

Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirao Preto, SP, Brazil.

Aim: This randomized placebo-controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019-containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis. Read More

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http://dx.doi.org/10.1111/jcpe.12995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221043PMC
October 2018

A Chinese family with periodontal Ehlers-Danlos syndrome associated with missense mutation in the C1R gene.

J Clin Periodontol 2018 Nov;45(11):1311-1318

Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Aim: We report a rare case of the periodontal Ehlers-Danlos syndrome (pEDS) associated with severe periodontitis and tooth loss in a Chinese family.

Material And Methods: The proband complained of gingival bleeding and mobility, which were also reported in his mother, and maternal uncle and his maternal grandmother and great-grandfather in the past. All family members underwent oral, physical, dermatological, and genetic examinations. Read More

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http://dx.doi.org/10.1111/jcpe.12988DOI Listing
November 2018
8 Reads

Effect of two periodontal treatment modalities in patients with uncontrolled type 2 diabetes mellitus: A randomized clinical trial.

J Clin Periodontol 2018 Sep 16;45(9):1098-1106. Epub 2018 Aug 16.

Department of Periodontology, Dentistry Faculty, Universidad de los Andes, Santiago, Chile.

Aim: To evaluate the impact of two non-surgical periodontal treatment modalities on metabolic and periodontal clinical parameters in subjects with type 2 diabetes mellitus (T2DM) and poor glycaemic control and chronic periodontitis.

Material And Methods: A randomized controlled clinical trial was conducted. Ninety-three T2DM subjects with glycosylated haemoglobin (HbA1c) > 7% were randomly assigned to one of two groups receiving scaling with root planing in multiple sessions quadrant-by-quadrant (Q by Q) or within 24 hr (one stage). Read More

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http://dx.doi.org/10.1111/jcpe.12991DOI Listing
September 2018

Clinical associations between acetylcholine levels and cholinesterase activity in saliva and gingival crevicular fluid and periodontal diseases.

J Clin Periodontol 2018 Oct 17;45(10):1173-1183. Epub 2018 Sep 17.

Oral Sciences Research Group, University of Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Aim: The oral mucosa possesses a non-neuronal cholinergic system. This study aimed to determine clinical evidence for a role of cholinergic mechanisms in the pathogenesis of periodontal diseases.

Materials And Methods: Fifty healthy participants, 52 patients with gingivitis and 49 with periodontitis were recruited. Read More

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http://dx.doi.org/10.1111/jcpe.12989DOI Listing
October 2018
12 Reads