5,442 results match your criteria Journal of Clinical Periodontology [Journal]


HIV Status Does Not Worsen Oral Health Outcomes.

J Clin Periodontol 2019 Apr 21. Epub 2019 Apr 21.

Department of Oral Biology, School of Dental Medicine, University of Pittsburgh.

Last January 31 , Journal of Clinical Periodontology just made available the report titled "A Retrospective Analysis of Dental Implant Survival in HIV Patients", which concluded that "implants placed in HIV-positive patients had similar survival rates as HIV-negative patients." These data support our hypothesis that infection by HIV does not lead to worse oral health outcomes, including worse periodontitis. We looked 6,092 individuals and selected all HIV-positive subjects (N=73) and matched them by age, sex, ethnicity, and smoking habits with 261 HIV-negative control subjects. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13116
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http://dx.doi.org/10.1111/jcpe.13116DOI Listing
April 2019
1 Read

Interaction between beta-3 adrenergic receptor genotype and environmental factors on periodontal progression.

J Clin Periodontol 2019 Apr 19. Epub 2019 Apr 19.

Department of Community, Oral Health Development, Kyushu Dental University, 2-6-1 Manazuru, Kokura-kita, Kitakyushu, Fukuoka, 803-8580, Japan.

Objectives: The purpose of this longitudinal study was to evaluate the relationship between beta-3 adrenergic receptor polymorphism and environmental factors such as smoking on periodontal disease by considering effect modification.

Material And Methods: A total of 294 subjects who participated in all follow-up surveys over the 6-year study period were analyzed. After dividing subjects into tertiles according to the number of years exposed to smoking, we conducted Poisson regression analysis to compare the incidence rate ratio (IRR) for periodontal disease events during the 6-year study period with beta-3 adrenergic receptor genotype (1: Arg allele carriers, 2: Arg allele non-carriers) for each tertile adjusted for other four variables. Read More

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http://dx.doi.org/10.1111/jcpe.13115DOI Listing

Periodontitis as the risk factor of chronic kidney disease: Mediation analysis.

J Clin Periodontol 2019 Apr 16. Epub 2019 Apr 16.

Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Aim: To determine sequences and magnitude of causality among periodontitis, diabetes and chronic kidney disease (CKD) by mediation analysis.

Methods: Ten-year-data were retrieved from the Electric Generation Authority of Thailand (EGAT) study. A cohort of 2,635 subjects was identified with no CKD at baseline. Read More

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http://dx.doi.org/10.1111/jcpe.13114DOI Listing

Dental treatment procedures for periodontal disease and the subsequent risk of ischemic stroke: a retrospective population-based cohort study.

J Clin Periodontol 2019 Apr 16. Epub 2019 Apr 16.

Dental Technology Centre, Changhua Christian Hospital, Changhua, Taiwan.

Aim: To investigate the association between specific dental therapy for periodontal disease and the risk of ischemic stroke.

Materials And Methods: We conducted a population-based cohort study that used data from the Taiwan National Health Insurance Research Database 2005 for the period of 2000-2013. Our observations focused on patients with the diagnoses of gingivitis or periodontitis with and without specific treatment and subsequent incidence of ischemic stroke. Read More

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http://dx.doi.org/10.1111/jcpe.13113DOI Listing

Oxidative stress-related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta-analysis.

J Clin Periodontol 2019 Apr 16. Epub 2019 Apr 16.

Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China.

Aim: Oxidative stress (OS) biomarkers have been detected in saliva and gingival crevicular fluid (GCF) during chronic periodontitis (CP) progression; however, the relationship between OS biomarkers and CP progression remains elusive. The purpose of this meta-analysis is to investigate the relationship between local OS biomarkers and CP.

Methods: This review was conducted through a systematic search from 3 databases. Read More

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http://dx.doi.org/10.1111/jcpe.13112DOI Listing
April 2019
1 Read

PICF proteome before and after adjunctive EMD treatment of peri-implantitis.

J Clin Periodontol 2019 Apr 15. Epub 2019 Apr 15.

Umeå University, Department of Molecular Periodontology, Umeå, Sweden.

Aim: The aim of this study was to explore which peri-implant crevicular fluid (PICF) protein pattern is associated with the active peri-implantitis process.

Materials And Methods: PICF from 25 peri-implantitis sites were subjected to proteomic analysis using liquid chromatography-tandem mass spectrometry before and at 3, 6 and 12 months after treatment, to identify associations between PICF protein pattern and implant loss, bleeding on probing, pocket depth, and enamel matrix derivative (EMD) treatment.

Results: Clustering of subjects based on their 3 to 12 months PICF proteomic profiles by principal component analysis defined two major clusters. Read More

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http://dx.doi.org/10.1111/jcpe.13108DOI Listing

Infrabony defects 20 years after open flap debridement and guided tissue regeneration.

J Clin Periodontol 2019 Apr 13. Epub 2019 Apr 13.

Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University, Frankfurt/Main, Theodor-Stern-Kai 7, 60596, Frankfurt/Main, Germany.

Aim: Evaluation of 20-year results after open flap debridement (OFD) and guided tissue regeneration (GTR) of infrabony defects in a randomized controlled trial.

Materials And Methods: In originally 16 periodontitis patients (baseline examination) periodontal surgery was performed in 44 infrabony defects. Polylactide acetyltributyl citrate barriers were randomly assigned to 23 out of these 44 defects (parallel). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13110
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http://dx.doi.org/10.1111/jcpe.13110DOI Listing
April 2019
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Prevalence and risk indicators of peri-implantitis in a sample of University-based dental patients in Italy: a cross-sectional study.

J Clin Periodontol 2019 Apr 12. Epub 2019 Apr 12.

Department of Periodontology, Università Vita e Salute, San Raffaele, Milano, Italy.

Aim: Reports regarding prevalence of peri-implant diseases show widely varying prevalence rates, which can be explained partially by variable diagnostic criteria adopted. Furthermore, several different factors have been associated with peri-implant diseases. Hence, the aim of this cross-sectional study is to i) determine the prevalence, extent and severity of peri-implant diseases in patients enrolled in a University Dental Clinic and ii) to evaluate the association between peri-implantitis and patient/implant-related factors. Read More

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http://dx.doi.org/10.1111/jcpe.13111DOI Listing

Long-term Stability of Root Coverage Procedures for Single Gingival Recessions: A Systematic Review and Meta-analysis.

J Clin Periodontol 2019 Apr 12. Epub 2019 Apr 12.

Department of Periodontology, Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.

Aim: To evaluate the long-term (≥ 2 years) stability of root coverage procedures for single gingival recessions.

Materials And Methods: A complete literature search was performed up to July 2018. Randomized controlled trials (RCTs) following ≥ 2 years were selected. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13106
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http://dx.doi.org/10.1111/jcpe.13106DOI Listing
April 2019
3 Reads

Letter to the editor: Oral hygiene phase revisited. How different study designs have affected results in intervention studies.

J Clin Periodontol 2019 Apr 11. Epub 2019 Apr 11.

Section for Oral Epidemiology and Public Health, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.

Every periodontal researcher have been taught, and every textbook in periodontics have advocated, that a phase in which the patient is meticulously motivated and instructed in proper oral hygiene - the oral hygiene phase - must be included in any periodontal intervention. However, how is this oral hygiene phase actually portrayed in periodontal intervention studies, and how much space have this important phase received in the planning and carry-through of intervention studies? The purpose of this letter to the editor was to review current literature in the period 1975/01/01 - 2017/12/31 on periodontal, mechanical intervention studies in order to see what focus the oral hygiene phase had received in these articles. The result showed that the oral hygiene phase is variable in length and content, variable in claimed result, insufficiently described, and invariably amalgamated with the scaling and root planing which is the intervention or part of an intervention. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13109
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http://dx.doi.org/10.1111/jcpe.13109DOI Listing
April 2019
4 Reads

Five year stability of clinical attachment after regenerative treatment of infrabony defects compared to controls.

J Clin Periodontol 2019 Apr 11. Epub 2019 Apr 11.

Dept. of Periodontology, Center for Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60596, Frankfurt am Main.

Aim: To evaluate the stability of attachment achieved in infrabony defects by regenerative treatment over 60±12 months compared to control teeth.

Methods: Patients treated regeneratively in at least one infrabony defect between 2004 and 2010 were screened for this retrospective cohort study. Complete examinations available for baseline, 12 and 60±12 months after surgery, and a respective control tooth without treatment, provided eligibility for analysis. Read More

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http://dx.doi.org/10.1111/jcpe.13105DOI Listing

The influence of an anti-inflammatory diet on gingivitis. A randomized controlled trial.

J Clin Periodontol 2019 Apr 2. Epub 2019 Apr 2.

Department of Restorative, Preventive and Pediatric Dentistry, University of Berne, Berne, Switzerland.

Aim: Aim of this study was to investigate the influence of an anti-inflammatory diet on different parameters in patients with gingivitis.

Materials And Methods: Thirty patients were randomly allocated to an experimental and a control group stratified by their plaque values. The experimental group had to change to a diet low in processed carbohydrates and animal proteins, and rich in omega-3 fatty acids, vitamin C, vitamin D, antioxidants, plant nitrates and fibres for 4 weeks. Read More

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http://dx.doi.org/10.1111/jcpe.13094DOI Listing
April 2019
1 Read

Development and validation of a predictive model for periodontitis using NHANES 2011-2012 data.

J Clin Periodontol 2019 Mar 19. Epub 2019 Mar 19.

Center for Clinical and Translational Research, Forsyth Institute, Cambridge, Massachusetts.

Aim: To develop and validate a predictive model for moderate-to-severe periodontitis in the adult USA population, with data from the 2011-2012 National Health and Nutrition Examination Survey (NHANES) cycle.

Material And Methods: A subset of 3017 subjects aged >30 years, with >14 teeth present and having received a periodontal examination in addition to data collected on cardio-metabolic risk measures (smoking habit, body mass index [BMI], blood pressure, total cholesterol and glycated haemoglobin [HbA1c]) were used for model development by multivariable logistic regression.

Results: The prevalence of moderate and severe periodontitis using CDC/AAP classification was 37. Read More

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http://dx.doi.org/10.1111/jcpe.13098DOI Listing
March 2019
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Implementation of the New Classification of Periodontal Diseases: Decision Making Algorithms for Clinical Practice and Education.

J Clin Periodontol 2019 Mar 18. Epub 2019 Mar 18.

European Research Group on Periodontology, Genova, Italy.

Background: Implementation of the new classification of periodontal diseases requires careful navigation of the new case definitions and organization of the diagnostic process along rationale and easily applicable algorithms. The aim of this report is to describe the rationale for one such approach designed for clinical practice and education.

Methods: The authors developed empiric decision-making algorithms based on the new classification to effectively discriminate between the key periodontal diagnoses of periodontal health, gingivitis and periodontitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13104
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http://dx.doi.org/10.1111/jcpe.13104DOI Listing
March 2019
12 Reads

Esthetic Assessment after Root Coverage of Multiple Adjacent Recessions with Coronally Advanced Flap with Adjunctive Collagen Matrix or Connective Tissue Graft: Randomized Clinical Trial.

J Clin Periodontol 2019 Mar 14. Epub 2019 Mar 14.

European Research Group on Periodontology (ERGOPerio), Genova, Italy.

Background: Few studies have looked at professional assessment or patient perception of esthetics after root coverage procedures. The addition of connective tissue grafts (CTG) seems to improve esthetic outcomes. The objective of this a priori analysis was to compare esthetics after addition of CTG or a collagen matrix (CMX) to coronally advanced flap (CAF). Read More

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http://dx.doi.org/10.1111/jcpe.13103DOI Listing
March 2019
2 Reads

"Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis".

J Clin Periodontol 2019 Mar 10. Epub 2019 Mar 10.

Department of Surgery and Integrated Clinic - Division of Periodontics, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.

Aim: This study evaluated the effects of 5-fluorouracil (5-FU) and cisplatin (CIS) in healthy periodontal tissues and in the early stages of experimental periodontitis (EP) in rats.

Methods: One hundred and eighty male rats were divided into three groups, which were submitted to the following systemic treatments: PSS - physiological saline solution (PSS); CIS - cisplatin and 5FU - 5-fluorouracil. Each group was subdivided into two subgroups: without (NEP) and with (EP) induction of experimental periodontitis. Read More

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http://dx.doi.org/10.1111/jcpe.13101DOI Listing

Industry sponsorship bias in clinical trials in implant dentistry: Systematic review and meta-regression.

J Clin Periodontol 2019 Mar 4. Epub 2019 Mar 4.

Graduate Program in Dentistry, Meridional Faculty/IMED, Passo Fundo, Brazil.

Aim: Industry sponsorship might distort the conduct and findings of studies in a large range of medical disciplines. The objective of this study was to assess whether industry sponsorship bias is present in randomized controlled trials (RCTs) on dental implants.

Material And Methods: Two databases were searched (MEDLINE; Web of Science) to identify RCTs published between 1996 and 2016 assessing different implant systems, components or techniques, such as implant-abutment connections, geometries, surfaces, loading protocols or regions of placement. Read More

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http://dx.doi.org/10.1111/jcpe.13100DOI Listing
March 2019
3 Reads

Association of non-surgical periodontal therapy on patients' oral health related quality-of-life - a multi-center cohort study.

J Clin Periodontol 2019 Mar 2. Epub 2019 Mar 2.

Department of Operative Dentistry and Periodontology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Aim: The aim of this multi-center cohort study was to investigate the association of non-surgical periodontal therapy (NST) on the oral health-related quality of life (OHRQoL) in general and related to severity of periodontal disease and treatment modalities.

Materials And Methods: One hundred seventy-two patients with periodontal disease from 18 dental practices were measured before and 6-8 weeks after NST using a standardized and validated OHRQoL instrument (Oral Health Impact Profile - G14, OHIP-G14). Another questionnaire was filled out by the dentists to evaluate the influence of treatment modalities and disease severity. Read More

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http://dx.doi.org/10.1111/jcpe.13093DOI Listing
March 2019
2 Reads

Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial.

J Clin Periodontol 2019 Mar 2. Epub 2019 Mar 2.

Department of Periodontology, University Hospital Münster, Münster, Germany.

Aim: The aim was to identify benefit thresholds for clinical variables. We hypothesize, if variables fall below or exceed these threshold levels, systemic amoxicillin/metronidazole may contribute to reducing progression of periodontitis.

Material & Methods: This is an explorative per-protocol collective analysis (n = 345) conducted on the placebo-controlled, multi-centre ABPARO trial (ClinicalTrials. Read More

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http://dx.doi.org/10.1111/jcpe.13096DOI Listing

Prevalence and predictive factors of dentin hypersensitivity in Brazilian adolescents.

J Clin Periodontol 2019 Mar 2. Epub 2019 Mar 2.

Associate Professor of the Dental Postgraduation Program at Federal University of Piauí (UFPI), Department of Restorative Dentistry, Teresina, PI, Brazil.

Aim: To measure the prevalence of dentin hypersensitivity (DH) in adolescents.

Methods: The diagnosis was based on self-report and was confirmed by tactile and evaporative tests. The association between DH and predictor factors was determined using a multivariate model. Read More

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http://dx.doi.org/10.1111/jcpe.13097DOI Listing
March 2019
1 Read

The adjunctive effect of a titanium brush in implant surface decontamination at peri-implantits surgical regenerative interventions: a randomized controlled clinical trial.

J Clin Periodontol 2019 Mar 2. Epub 2019 Mar 2.

Universitat International de Catalunya.

Aim: To evaluate an additional mechanical approach, a titanium brush, in the implant-surface decontamination performed during the regenerative surgical therapy of peri-implantitis.

Material And Methods: A randomized double-blinded clinical trial, with a 1-year follow-up, was carried out. After a hygienic phase, peri-implantitis affected implants were randomly assigned to a control or to a test group. Read More

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http://doi.wiley.com/10.1111/jcpe.13095
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http://dx.doi.org/10.1111/jcpe.13095DOI Listing
March 2019
5 Reads

Decreased salivary concentration of CD9 and CD81 exosome-related tetraspanins may be associated with the periodontal clinical status.

J Clin Periodontol 2019 Mar 2. Epub 2019 Mar 2.

Laboratory of Immunodetection and Bioanalysis, Faculty of Dentistry, University of Antioquia, Medellín, Colombia.

Aim: This cross-sectional case-control study was designed to determine the association of the salivary concentration of CD9/CD81 exosome-related tetraspanins with the periodontal clinical status.

Materials And Methods: Saliva samples from 104 periodontitis patients and 45 healthy controls were collected. Periodontal status was assessed based on full-mouth clinico-radiographical data, and salivary concentration of the analytes was calculated by ELISA. Read More

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http://dx.doi.org/10.1111/jcpe.13099DOI Listing

Effectiveness and clinical performance of early implant placement for the replacement of single teeth in anterior areas: A systematic review.

J Clin Periodontol 2019 Mar 1. Epub 2019 Mar 1.

Department of Periodontology, School of Dental Medicine, University of Bern (Switzerland).

Aim: To assess the effectiveness and clinical performance of early implant placement, 4-8 (Type 2) or 12-16 weeks (Type 3) after extraction, in single anterior sites.

Methods: Studies reporting on Type 2 and 3 implant placement were identified. Findings were summarized in evidence tables. Read More

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http://doi.wiley.com/10.1111/jcpe.13092
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http://dx.doi.org/10.1111/jcpe.13092DOI Listing
March 2019
13 Reads

Association between central obesity and tooth loss in the non-obese people: Results from the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2012.

J Clin Periodontol 2019 Feb 21. Epub 2019 Feb 21.

Division of Applied Health and Clinical Translation, School of Dentistry, University of Leeds, Leeds, UK.

Objectives: This study was to investigate the association between central obesity and tooth loss in non-obese population.

Material And Methods: This national cross-sectional study included 19436 participants, aged 19-74 years with body mass index(BMI) 18.5-29. Read More

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http://dx.doi.org/10.1111/jcpe.13091DOI Listing
February 2019

Influence of autoclavation on the efficacy of extracted tooth roots used for vertical alveolar ridge augmentation.

J Clin Periodontol 2019 Feb 21. Epub 2019 Feb 21.

Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany.

Objectives: To assess the influence of autoclavation on the efficacy of extracted tooth roots (TR) used for vertical alveolar ridge augmentation and two-stage osseointegration.

Material And Methods: Maxillary premolars were randomly assigned to either autoclavation (TR-A) or were left untreated (TR-C) and used as block grafts for vertical alveolar ridge augmentation in both lower quadrants (n = 4 beagle dogs). At 12 weeks, titanium implants were inserted and left to heal for 3 weeks. Read More

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http://dx.doi.org/10.1111/jcpe.13090DOI Listing
February 2019

Clinical effects of the adjunctive use of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse in the management of peri-implant diseases: A randomized clinical trial.

J Clin Periodontol 2019 Mar;46(3):342-353

ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain.

Aim: To evaluate the efficacy of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse, as an adjunct to professionally and patient-administered mechanical plaque removal, in the treatment of peri-implant mucositis (PiM). Read More

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http://dx.doi.org/10.1111/jcpe.13088DOI Listing
March 2019
8 Reads

Periodontal health: A national cross-sectional study of knowledge, attitudes and practices for the public oral health strategy in China.

J Clin Periodontol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Aim: To assess the status of periodontal health knowledge, attitudes and practices (KAP) among Chinese adults.

Materials And Methods: A cross-sectional study was conducted in a nationally representative sample of adults (N = 50,991) aged 20 years or older from ten provinces, autonomous regions, and municipalities. Percentages of Chinese adults with correct periodontal knowledge, positive periodontal attitudes, and practices were estimated. Read More

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http://dx.doi.org/10.1111/jcpe.13082DOI Listing
February 2019
3 Reads

secreted Frizzled-Related Protein 5 Serum Levels in Human Periodontitis - a nested case-control study.

J Clin Periodontol 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Aim: Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach.

Materials And Methods: sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. Read More

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http://dx.doi.org/10.1111/jcpe.13087DOI Listing
February 2019

Effect of mHealth in improving oral hygiene: A systematic review with meta-analysis.

J Clin Periodontol 2019 Mar;46(3):297-309

Department of Periodontology, Federal University Rio Grande do Sul, Porto Alegre, Brazil.

Aim: To evaluate the effectiveness of mobile applications and text messages, compared with conventional oral hygiene instructions, for improving oral health knowledge and/or reducing gingival inflammation, when delivered to adolescents, adults and mothers of young children.

Methods: Randomized clinical trials evaluating the use of mobile applications or text messages related to oral hygiene and/or oral health education were screened. A search was performed in the Medline-PubMed, Scopus and Embase databases and the grey literature. Read More

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http://dx.doi.org/10.1111/jcpe.13083DOI Listing

The guardians of the periodontium-sequential and differential expression of antimicrobial peptides during gingival inflammation. Results from in vivo and in vitro studies.

J Clin Periodontol 2019 Mar 6;46(3):276-285. Epub 2019 Mar 6.

Department of Periodontology, Operative and Preventive Dentistry, University Hospital Bonn, Bonn, Germany.

Aim: To evaluate the sequential and differential expression of a variety of antimicrobial peptides (AMPs) during the development of an experimentally induced gingivitis in humans.

Material And Methods: In twenty healthy volunteers, gingival inflammation was induced by abstention from oral hygiene at 6 teeth. Bleeding on probing (BOP) and plaque index (PI) were assessed, and gingival biopsies and gingival crevicular fluid (GCF) were collected at 8 different time points (t0-t35). Read More

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http://dx.doi.org/10.1111/jcpe.13084DOI Listing

Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months.

J Clin Periodontol 2019 Mar 6;46(3):321-331. Epub 2019 Mar 6.

Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Aim: To assess the effect of periodontal therapy (PT) on cardiovascular blood biomarkers.

Materials And Methods: This single-blind, parallel-design, randomized controlled trial included patients with stable coronary artery disease and periodontitis. The test group (TG) received non-surgical PT, whereas the control group (CG) received one session of plaque removal. Read More

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http://doi.wiley.com/10.1111/jcpe.13085
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http://dx.doi.org/10.1111/jcpe.13085DOI Listing
March 2019
7 Reads

Treatment of intrabony periodontal defects using rhFGF-2 in combination with deproteinized bovine bone mineral or rhFGF-2 alone: A 6-month randomized controlled trial.

J Clin Periodontol 2019 Mar;46(3):332-341

Department of Periodontology, Tokyo Dental College, Tokyo, Japan.

Aim: To evaluate the use of recombinant human fibroblast growth factor (rhFGF)-2 in combination with deproteinized bovine bone mineral (DBBM) compared with rhFGF-2 alone, in the treatment of intrabony periodontal defects.

Materials And Methods: Patients with periodontitis who had received initial periodontal therapy and had intrabony defects of ≥ 3 mm in depth were enrolled. Sites were randomly assigned to receive a commercial formulation of 0. Read More

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http://dx.doi.org/10.1111/jcpe.13086DOI Listing
March 2019
1 Read

Interdental cleaning and periodontal pocketing among finnish adults.

J Clin Periodontol 2019 Mar 6;46(3):310-320. Epub 2019 Mar 6.

Department of Oral Public Health, Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.

Aim: To investigate the relationship between frequency of interdental cleaning and 11-year change in teeth with periodontal pocketing in Finnish adults.

Methods: Data from 1667 dentate adults, aged 30 to 82 years, who participated in the Health 2000 survey and were re-examined in 2004 and/or 2011 were analysed. Participants reported their frequency of interdental cleaning (either dental floss or interdental brush) at baseline. Read More

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http://dx.doi.org/10.1111/jcpe.13081DOI Listing
March 2019
1 Read

Antibiotic prophylaxis at dental implant placement: Which is the best protocol? A systematic review and network meta-analysis.

J Clin Periodontol 2019 Mar;46(3):382-395

Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy.

Aim: This systematic review of randomized controlled trials (RCTs) aims to answer to the following question: "In patients undergoing dental implant placement, which is the best antibiotic prophylaxis protocol to prevent early failures?"

Materials And Methods: The MEDLINE, SCOPUS, CENTRAL and Web of Knowledge electronic databases were searched in duplicate for RCTs up to July 2017. Additional relevant literature was identified through (i) handsearching on both relevant journals and reference lists, and (ii) searching in databases for grey literature. A network meta-analysis (NMA) was conducted, and the probability that each protocol is the "Best" was estimated. Read More

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http://dx.doi.org/10.1111/jcpe.13080DOI Listing

Chronic periodontitis and reduced respiratory function.

J Clin Periodontol 2019 Mar 27;46(3):266-275. Epub 2019 Feb 27.

Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.

Objective: To investigate whether there was an association between chronic periodontitis (CP) and reduced respiratory function.

Methods: A group of dentate 58- to 72-year-old men in Northern Ireland had a comprehensive periodontal examination. Parallel to the periodontal examination, participants completed questionnaires gathering information on their medical history, social circumstances, demographic background and tobacco use. Read More

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http://dx.doi.org/10.1111/jcpe.13076DOI Listing
March 2019
2 Reads

Comparison between two bone substitutes for alveolar ridge preservation after tooth extraction: Cone-beam computed tomography results of a non-inferiority randomized controlled trial.

J Clin Periodontol 2019 Mar 3;46(3):373-381. Epub 2019 Mar 3.

Discipline of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Aim: To test the non-inferiority of demineralized bovine bone mineral (DBBM) compared to DBBM with 10% collagen (DBBM-C) for maintenance of bone volume after tooth extraction in the anterior maxilla.

Materials And Methods: Sixty-six patients were randomly treated with DBBM or DBBM-C, both of which were covered with a collagen matrix for ridge preservation in the anterior maxilla. Cone-beam computed tomographic analysis was performed immediately and 4 months after treatment. Read More

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http://dx.doi.org/10.1111/jcpe.13079DOI Listing
March 2019
1 Read

The amount of keratinized mucosa may not influence peri-implant health in compliant patients: A retrospective 5-year analysis.

J Clin Periodontol 2019 Mar 7;46(3):354-362. Epub 2019 Mar 7.

Clinic of Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich, Zurich, Switzerland.

Aim: (a) To investigate the influence of the keratinized mucosa (KM) on peri-implant health or disease and (b) to identify a threshold value for the width of KM for peri-implant health.

Materials And Methods: The total dataset was subsampled, that is one implant was randomly chosen per patient. In 87 patients, data were extracted at baseline (prosthesis insertion) and 5 years including the width of mid-buccal KM, bleeding on probing, probing depth, plaque index and marginal bone level (MB). Read More

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A retrospective analysis of dental implant survival in HIV patients.

J Clin Periodontol 2019 Mar 18;46(3):363-372. Epub 2019 Feb 18.

Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, Texas.

Aim: This 5 years retrospective cohort survival study compared failure rates of dental implants placed in HIV (+) and HIV (-) patients relative to several risk factors.

Materials And Methods: Between 2006 and 2015, 484 implants placed in HIV (+) patients and 805 implants placed in HIV (-) patients were assessed for survival. The effects of HIV were estimated using propensity weighting. Read More

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http://doi.wiley.com/10.1111/jcpe.13077
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http://dx.doi.org/10.1111/jcpe.13077DOI Listing
March 2019
25 Reads

Self-regenerative capacity of intraoral bone defects.

J Clin Periodontol 2019 Jan 30. Epub 2019 Jan 30.

Department of Periodontology, School of Dental Medicine, University of Bern, Switzerland.

Objective: To provide an overview on the self-regenerative capacity of various types of intraoral bone defects.

Materials And Methods: This paper has narratively reviewed the most important aspects of bone biology and the healing outcomes related to the self-regenerative capacity (i.e. Read More

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http://dx.doi.org/10.1111/jcpe.13075DOI Listing
January 2019
2 Reads

Efficacy of lateral bone augmentation performed simultaneously with dental implant placement. A systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 23. Epub 2019 Jan 23.

Section of Graduate Periodontology, University Complutense, Madrid, Spain.

Objectives: To analyze the evidence regarding the efficacy of lateral bone augmentation procedures in terms of defect resolution in cases of horizontal ridge deficiencies after implant placement.

Materials And Methods: Included studies met the following inclusion criteria: randomized controlled trials (RCTs) or controlled clinical trials (CCT's), re-entry procedure to assess defect resolution, minimum of 10 patients (5 per group). Meta-analyses were performed whenever possible, including subgroup analysis based on membranes and grafting materials. Read More

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http://dx.doi.org/10.1111/jcpe.13050DOI Listing
January 2019
6 Reads

Barrier membranes: more than the barrier effect?

J Clin Periodontol 2019 Jan 22. Epub 2019 Jan 22.

Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Box 412, SE-405 30, Gothenburg, Sweden.

Aim: To review the knowledge on the mechanisms controlling membrane-host interactions in guided bone regeneration (GBR) and investigate the possible role of GBR membranes as bioactive compartments in addition to their established role as barriers.

Material & Methods: A narrative review was utilized based on in vitro, in vivo and available clinical studies on the cellular and molecular mechanisms underlying GBR and the possible bioactive role of membranes.

Results: Emerging data demonstrate that the membrane contributes bioactively to the regeneration of underlying defects. Read More

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http://dx.doi.org/10.1111/jcpe.13068DOI Listing
January 2019

Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 22. Epub 2019 Jan 22.

Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Objectives: The present systematic review aimed at evaluating the efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects.

Methods: Studies reporting on outcomes of reconstructive surgery at peri-implantitis-related bone defects at 12 months were identified through an electronic search. Following data extraction, two different sets of meta-analyses were performed. Read More

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http://dx.doi.org/10.1111/jcpe.13070DOI Listing
January 2019
1 Read

Effectiveness of vertical ridge augmentation interventions. A systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 22. Epub 2019 Jan 22.

ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain.

Aim: The primary aim of this systematic review was to evaluate the effect of various techniques used for vertical ridge augmentation on clinical vertical bone gain.

Material And Methods: A protocol was developed to answer the following focused question: "In patients with vertical alveolar ridge deficiencies, how effective are different augmentation procedures for clinical alveolar ridge gain?" Randomized and controlled clinical trials and prospective and retrospective case series were included, and meta-analyses were performed to evaluate vertical bone gain based on the type of procedure and to compare bone gains in controlled studies.

Results: Thirty-six publications were included. Read More

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http://dx.doi.org/10.1111/jcpe.13061DOI Listing
January 2019
7 Reads

Enamel matrix derivative stabilizes blood clot and improves clinical healing in deep pockets after flapless periodontal therapy: A Randomized Clinical Trial.

J Clin Periodontol 2019 Feb;46(2):231-240

Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China.

Aim: An acute phase response is induced after non-surgical periodontal treatment (SRP). The main aim of this study was to compare acute phase (24-hr) and medium-term (3-months) inflammation and clinical outcomes after SRP with or without application of enamel matrix derivative (EMD) in sites with probing pocket depth (PPD) ≥ 6 mm.

Methods: Thirty-eight periodontitis-affected subjects were randomized to SRP or SRP + EMD. Read More

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http://dx.doi.org/10.1111/jcpe.13074DOI Listing
February 2019
4 Reads

Effect of socket-shield technique on alveolar ridge soft and hard tissue in dogs.

J Clin Periodontol 2019 Feb;46(2):256-263

Department of Oral Implantology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.

Aim: To study the soft and hard tissue alterations of the alveolar ridge after socket-shield technique.

Materials And Methods: In four Beagle dogs, the following treatments (Tx) were randomly assigned to 32 extraction sockets: Tx1: blood clot; Tx2: Bio-Oss Collagen; Tx3: socket-shield technique and blood clot; Tx4: socket-shield technique and Bio-Oss Collagen. The width and height alterations of the buccal bone plate were calculated by CBCT scans. Read More

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http://doi.wiley.com/10.1111/jcpe.13073
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http://dx.doi.org/10.1111/jcpe.13073DOI Listing
February 2019
8 Reads

Relationship of periodontal disease and domains of oral health-related quality of life.

J Clin Periodontol 2019 Feb 3;46(2):170-180. Epub 2019 Feb 3.

Department of Dentistry and Oral Health, La Trobe Rural Health School, La Trobe University, Bendigo, Victoria, Australia.

Objectives: The aim of this study was to investigate the impact of periodontal disease on the domains of oral health-related quality of life (OHRQoL) of United Kingdom adults.

Methods: National representative data from the 2009 Adult Dental Health Survey, United Kingdom, were used in this study. Periodontal disease severity was measured using periodontal pocket depth and categorized into three groups: pocket depth up to 3. Read More

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http://doi.wiley.com/10.1111/jcpe.13072
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http://dx.doi.org/10.1111/jcpe.13072DOI Listing
February 2019
20 Reads

Association between periodontal disease and preterm prelabour rupture of membranes.

J Clin Periodontol 2019 Feb 3;46(2):189-196. Epub 2019 Feb 3.

Department of Obstetrics and Gynecology, Faculty of Medicine in Hradec Kralove, University Hospital in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.

Objective: Periodontal disease is a possible contributing factor to preterm delivery. The aim of this study was to compare the periodontal status of women with preterm prelabour rupture of membranes (PPROM) and women with uncomplicated singleton pregnancies.

Patients And Methods: Seventy-eight women with PPROM at gestational ages between 24 + 0 and 36 + 6 weeks and 77 healthy women with uncomplicated pregnancies, matched for gestational age at sampling without preterm birth, were included in this study. Read More

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http://dx.doi.org/10.1111/jcpe.13067DOI Listing
February 2019
3 Reads

The depth of the implant mucosal tunnel modifies the development and resolution of experimental peri-implant mucositis: A case-control study.

J Clin Periodontol 2019 Feb 7;46(2):248-255. Epub 2019 Feb 7.

Department of Periodontology, Faculty of Dentistry, Hong Kong University, Hong Kong, SAR, China.

Background: Resolution and prevention of peri-implant mucositis are a key in preventing peri-implantitis. This case-control study aims to assess the modifying effect of a deep mucosal tunnel (DMT) on the induction and resolution phases of experimental peri-implant mucositis.

Methods: Nineteen subjects with a tissue level implant were assigned to cases (DMT, depth ≥3 mm) or controls (shallow mucosal tunnel ≤1 mm, SMT). Read More

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http://dx.doi.org/10.1111/jcpe.13066DOI Listing
February 2019
4 Reads

Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signalling pathway.

J Clin Periodontol 2019 Mar 10;46(3):286-296. Epub 2019 Mar 10.

The State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Sichuan, China.

Aim: In this study, we investigate the mechanistic link between rheumatoid arthritis (RA) and periodontitis to identify a novel target (cathepsin K; Ctsk) for the treatment of comorbid periodontitis and RA.

Methods: An experimental model of periodontitis with arthritis was established in DBA/1 mice. We then tested the effect of BML-244, a specific inhibitor of Ctsk, by quantifying several inflammatory markers of TLR9 signalling both in vivo and in vitro. Read More

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http://doi.wiley.com/10.1111/jcpe.13060
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http://dx.doi.org/10.1111/jcpe.13060DOI Listing
March 2019
12 Reads
4.010 Impact Factor

New insights in the link between malocclusion and periodontal disease.

J Clin Periodontol 2019 Feb;46(2):144-159

Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University Medicine Greifswald, Greifswald, Germany.

Aim: We aimed to investigate associations between malocclusions and periodontal disease by comparing it to that of smoking in subjects recruited from the population-based cross-sectional study "Study of Health in Pomerania."

Materials And Methods: Sagittal intermaxillary relationship, variables of malocclusion and socio-demographic parameters of 1,202 dentate subjects, 20-39 years of age, were selected. Probing depth (PD) and attachment loss (AL) were assessed at four sites by tooth in a half-mouth design. Read More

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http://doi.wiley.com/10.1111/jcpe.13062
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http://dx.doi.org/10.1111/jcpe.13062DOI Listing
February 2019
5 Reads