5,420 results match your criteria Journal of Clinical Periodontology [Journal]


Association between central obesity and tooth loss in the non-obese people: results from the continuous national health and nutrition examination survey (NHANES) 1999-2012.

J Clin Periodontol 2019 Feb 21. Epub 2019 Feb 21.

Division of Applied Health and Clinical Translation, School of Dentistry, University of Leeds, UK.

Objectives: This study is to investigate the association between central obesity and tooth loss in non-obese population.

Material And Methods: This national cross-sectional study included 19436 participants, aged 19-74 years with body mass index(BMI) 18.5-29. Read More

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http://dx.doi.org/10.1111/jcpe.13091DOI Listing
February 2019

Influence of autoclavation on the efficacy of extracted tooth roots used for vertical alveolar ridge augmentation.

J Clin Periodontol 2019 Feb 21. Epub 2019 Feb 21.

Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany.

Objectives: To assess the influence of autoclavation on the efficacy of extracted tooth roots (TR) used for vertical alveolar ridge augmentation and two-stage osseointegration.

Material & Methods: Maxillary premolars were randomly assigned to either autoclavation (TR-A) or were left untreated (TR-C) and used as block grafts for vertical alveolar ridge augmentation in both lower quadrants (n=4 beagle dogs). At 12 weeks, titanium implants were inserted and left to heal for 3 weeks. Read More

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http://dx.doi.org/10.1111/jcpe.13090DOI Listing
February 2019

Clinical effects of the adjunctive use of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse in the management of peri-implant diseases: a randomized clinical trial.

J Clin Periodontol 2019 Feb 18. Epub 2019 Feb 18.

ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain.

Aim: To evaluate the efficacy of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth-rinse, as an adjunct to professionally and patient-administered mechanical plaque removal, in the treatment of peri-implant mucositis (PiM). Read More

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http://dx.doi.org/10.1111/jcpe.13088DOI Listing
February 2019

Periodontal health: a national cross-sectional study of knowledge, attitudes and practices for the public oral health strategy in China.

J Clin Periodontol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Aim: To assess the status of periodontal health knowledge, attitudes and practices (KAP) among Chinese adults.

Materials And Methods: A cross-sectional study was conducted in a nationally representative sample of adults (N=50991) aged 20 years or older from ten provinces, autonomous regions, and municipalities. Percentages of Chinese adults with correct periodontal knowledge, positive periodontal attitudes and practices were estimated. Read More

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http://dx.doi.org/10.1111/jcpe.13082DOI Listing
February 2019
1 Read

secreted Frizzled-Related Protein 5 Serum Levels in Human Periodontitis - a nested case-control study.

J Clin Periodontol 2019 Feb 14. Epub 2019 Feb 14.

Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Aim: Recombinant secreted frizzled-related protein 5 (sFRP5) improved periodontal status in mice. Thus, this study aimed to investigate this finding in human periodontitis using an epidemiological approach.

Materials And Methods: sFRP5 and wnt5a concentrations were determined in human serum from the Food Chain Plus cohort using ELISAs. Read More

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http://dx.doi.org/10.1111/jcpe.13087DOI Listing
February 2019

Effect of mHealth in improving oral hygiene: a systematic review with meta-analysis.

J Clin Periodontol 2019 Feb 13. Epub 2019 Feb 13.

Department of Periodontology, Federal University Rio Grande do Sul, Porto Alegre, Brazil.

Aim: To evaluate the effectiveness of mobile applications and text messages, compared with conventional oral hygiene instructions, for improving oral health knowledge and/or reducing gingival inflammation, when delivered to adolescents, adults and mothers of young children.

Methods: Randomized clinical trials evaluating the use of mobile applications or text messages related to oral hygiene and/or oral health education were screened. A search was performed in the Medline-PubMed, Scopus and Embase databases and the gray literature. Read More

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http://dx.doi.org/10.1111/jcpe.13083DOI Listing
February 2019

The Guardians of the Periodontium - Sequential and Differential Expression of Antimicrobial Peptides during Gingival Inflammation. Results from in vivo and in vitro studies.

J Clin Periodontol 2019 Feb 13. Epub 2019 Feb 13.

Department of Periodontology, Operative and Preventive Dentistry, University Hospital Bonn, Bonn, Germany.

Aim: To evaluate the sequential and differential expression of antimicrobial peptides (AMPs), human beta-defensins (hBD-2, hBD-3), CC-chemokine ligand 20 (CCL20), S100A7/psoriasin (S100A7), and calgranulin A/B (S100A8, S100A9), during the development of an experimentally induced gingivitis in humans.

Material And Methods: In twenty healthy volunteers, gingival inflammation was induced by abstention from oral hygiene at 6 teeth. Bleeding on probing (BOP) and plaque index (PI) were assessed, and gingival biopsies and gingival crevicular fluid (GCF) were collected at 8 different time-points (t0-t35). Read More

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http://dx.doi.org/10.1111/jcpe.13084DOI Listing
February 2019

Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: preliminary findings of 3 months.

J Clin Periodontol 2019 Feb 14. Epub 2019 Feb 14.

Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Aim: To assess the effect of periodontal therapy (PT) on cardiovascular blood biomarkers.

Materials And Methods: This single-blind, parallel design, randomized controlled trial included patients with stable coronary artery disease and periodontitis. The test group (TG) received non-surgical PT, whereas the control group (CG) received one session of plaque removal. Read More

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http://doi.wiley.com/10.1111/jcpe.13085
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http://dx.doi.org/10.1111/jcpe.13085DOI Listing
February 2019
4 Reads

Treatment of intrabony periodontal defects using rhFGF-2 in combination with deproteinized bovine bone mineral or rhFGF-2 alone: A 6-month randomized controlled trial.

J Clin Periodontol 2019 Feb 13. Epub 2019 Feb 13.

Department of Periodontology, Tokyo Dental College, Tokyo, Japan.

Aim: To evaluate the use of recombinant human fibroblast growth factor (rhFGF)-2 in combination with deproteinized bovine bone mineral (DBBM) compared with rhFGF-2 alone, in the treatment of intrabony periodontal defects.

Materials And Methods: Patients with periodontitis who had received initial periodontal therapy and had intrabony defects of > 3 mm were enrolled. Sites were randomly assigned to receive 0. Read More

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http://dx.doi.org/10.1111/jcpe.13086DOI Listing
February 2019

Interdental Cleaning and Periodontal Pocketing among Finnish Adults.

J Clin Periodontol 2019 Feb 8. Epub 2019 Feb 8.

Department of Oral Public Health, Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.

Aim: To investigate the relationship between frequency of interdental cleaning and 11-year change in teeth with periodontal pocketing in Finnish adults.

Methods: Data from 1667 dentate adults, aged 30 to 82 years, who participated in the Health 2000 survey and were re-examined in 2004 and/or 2011 were analysed. Participants reported their frequency of interdental cleaning (either dental floss or interdental brush) at baseline. Read More

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http://dx.doi.org/10.1111/jcpe.13081DOI Listing
February 2019
1 Read

Antibiotic Prophylaxis at Dental Implant Placement: Which is the Best Protocol? A Systematic Review and Network Meta-Analysis.

J Clin Periodontol 2019 Feb 7. Epub 2019 Feb 7.

Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy.

Aim: This systematic review of randomized controlled trials (RCTs) aims to answer to the following question: "In patients undergoing dental implant placement, which is the best antibiotic prophylaxis protocol to prevent early failures?".

Materials And Methods: The MEDLINE, SCOPUS, CENTRAL and Web of Knowledge electronic databases were searched in duplicate for RCTs up to July 2017. Additional relevant literature was identified through 1) hand-searching on both relevant journals and on reference lists, and 2) searching in databases for grey literature. Read More

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http://dx.doi.org/10.1111/jcpe.13080DOI Listing
February 2019

Chronic periodontitis and reduced respiratory function.

J Clin Periodontol 2019 Feb 3. Epub 2019 Feb 3.

Centre for Public Health, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, Northern Ireland.

Objective: To investigate whether there was an association between chronic periodontitis and reduced respiratory function.

Methods: A group of dentate 58-72 year-old men in Northern Ireland had a comprehensive periodontal examination. Parallel to the periodontal examination, participants completed questionnaires gathering information on their medical history, social circumstances, demographic background and tobacco use. Read More

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http://dx.doi.org/10.1111/jcpe.13076DOI Listing
February 2019
2 Reads

Comparison between two bone substitutes for alveolar ridge preservation after tooth extraction: Cone beam computed tomography results of a non-inferiority randomized controlled trial.

J Clin Periodontol 2019 Feb 1. Epub 2019 Feb 1.

Discipline of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Aim: To test the non-inferiority of demineralized bovine bone mineral (DBBM) compared to DBBM with 10% collagen (DBBM-C) for maintenance of bone volume after tooth extraction in the anterior maxilla.

Materials And Methods: Sixty-six patients were randomly treated with DBBM or DBBM-C, both of which were covered with a collagen matrix for ridge preservation in the anterior maxilla. Cone beam computed tomographic analysis was performed immediately and 4 months after treatment. Read More

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http://dx.doi.org/10.1111/jcpe.13079DOI Listing
February 2019

The amount of keratinized mucosa may not influence peri-implant health in compliant patients: a retrospective 5-year analysis.

J Clin Periodontol 2019 Feb 2. Epub 2019 Feb 2.

Clinic of Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich, Zurich, Switzerland.

Aim: (i) to investigate the influence of the keratinized mucosa (KM) on peri-implant health or disease, and (ii) to identify a threshold value for the width of KM for peri-implant health.

Materials & Methods: The total dataset was subsampled, i.e. Read More

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http://dx.doi.org/10.1111/jcpe.13078DOI Listing
February 2019

A retrospective analysis of dental implant survival in HIV patients.

J Clin Periodontol 2019 Jan 31. Epub 2019 Jan 31.

Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, Texas.

Aim: This 5 years retrospective cohort survival study compared failure rates of dental implants placed in HIV (+) and HIV (-) patients relative to several risk factors.

Materials And Methods: Between 2006 and 2015, 484 implants placed in HIV (+) patients and 805 implants placed in HIV (-) patients were assessed for survival. The effects of HIV were estimated using propensity weighting. Read More

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http://doi.wiley.com/10.1111/jcpe.13077
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http://dx.doi.org/10.1111/jcpe.13077DOI Listing
January 2019
4 Reads

Self-regenerative capacity of intraoral bone defects.

J Clin Periodontol 2019 Jan 30. Epub 2019 Jan 30.

Department of Periodontology, School of Dental Medicine, University of Bern, Switzerland.

Objective: To provide an overview on the self-regenerative capacity of various types of intraoral bone defects.

Materials And Methods: This paper has narratively reviewed the most important aspects of bone biology and the healing outcomes related to the self-regenerative capacity (i.e. Read More

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http://dx.doi.org/10.1111/jcpe.13075DOI Listing
January 2019
1 Read

Efficacy of lateral bone augmentation performed simultaneously with dental implant placement. A systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 23. Epub 2019 Jan 23.

Section of Graduate Periodontology, University Complutense, Madrid, Spain.

Objectives: To analyze the evidence regarding the efficacy of lateral bone augmentation procedures in terms of defect resolution in cases of horizontal ridge deficiencies after implant placement.

Materials And Methods: Included studies met the following inclusion criteria: randomized controlled trials (RCTs) or controlled clinical trials (CCT's), re-entry procedure to assess defect resolution, minimum of 10 patients (5 per group). Meta-analyses were performed whenever possible, including subgroup analysis based on membranes and grafting materials. Read More

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http://dx.doi.org/10.1111/jcpe.13050DOI Listing
January 2019
6 Reads

Barrier membranes: more than the barrier effect?

J Clin Periodontol 2019 Jan 22. Epub 2019 Jan 22.

Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Box 412, SE-405 30, Gothenburg, Sweden.

Aim: To review the knowledge on the mechanisms controlling membrane-host interactions in guided bone regeneration (GBR) and investigate the possible role of GBR membranes as bioactive compartments in addition to their established role as barriers.

Material & Methods: A narrative review was utilized based on in vitro, in vivo and available clinical studies on the cellular and molecular mechanisms underlying GBR and the possible bioactive role of membranes.

Results: Emerging data demonstrate that the membrane contributes bioactively to the regeneration of underlying defects. Read More

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http://dx.doi.org/10.1111/jcpe.13068DOI Listing
January 2019

Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 22. Epub 2019 Jan 22.

Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Objectives: The present systematic review aimed at evaluating the efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects.

Methods: Studies reporting on outcomes of reconstructive surgery at peri-implantitis-related bone defects at 12 months were identified through an electronic search. Following data extraction, two different sets of meta-analyses were performed. Read More

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http://dx.doi.org/10.1111/jcpe.13070DOI Listing
January 2019

Effectiveness of vertical ridge augmentation interventions. A systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 22. Epub 2019 Jan 22.

ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense, Madrid, Spain.

Aim: The primary aim of this systematic review was to evaluate the effect of various techniques used for vertical ridge augmentation on clinical vertical bone gain.

Material And Methods: A protocol was developed to answer the following focused question: "In patients with vertical alveolar ridge deficiencies, how effective are different augmentation procedures for clinical alveolar ridge gain?" Randomized and controlled clinical trials and prospective and retrospective case series were included, and meta-analyses were performed to evaluate vertical bone gain based on the type of procedure and to compare bone gains in controlled studies.

Results: Thirty-six publications were included. Read More

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http://dx.doi.org/10.1111/jcpe.13061DOI Listing
January 2019
2 Reads

Enamel matrix derivative stabilizes blood clot and improves clinical healing in deep pockets after flapless periodontal therapy: A Randomized Clinical Trial.

J Clin Periodontol 2019 Feb;46(2):231-240

Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China.

Aim: An acute phase response is induced after non-surgical periodontal treatment (SRP). The main aim of this study was to compare acute phase (24-hr) and medium-term (3-months) inflammation and clinical outcomes after SRP with or without application of enamel matrix derivative (EMD) in sites with probing pocket depth (PPD) ≥ 6 mm.

Methods: Thirty-eight periodontitis-affected subjects were randomized to SRP or SRP + EMD. Read More

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http://dx.doi.org/10.1111/jcpe.13074DOI Listing
February 2019
2 Reads

Effect of socket-shield technique on alveolar ridge soft and hard tissue in dogs.

J Clin Periodontol 2019 Feb;46(2):256-263

Department of Oral Implantology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.

Aim: To study the soft and hard tissue alterations of the alveolar ridge after socket-shield technique.

Materials And Methods: In four Beagle dogs, the following treatments (Tx) were randomly assigned to 32 extraction sockets: Tx1: blood clot; Tx2: Bio-Oss Collagen; Tx3: socket-shield technique and blood clot; Tx4: socket-shield technique and Bio-Oss Collagen. The width and height alterations of the buccal bone plate were calculated by CBCT scans. Read More

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http://doi.wiley.com/10.1111/jcpe.13073
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http://dx.doi.org/10.1111/jcpe.13073DOI Listing
February 2019
4 Reads

Relationship of periodontal disease and domains of oral health-related quality of life.

J Clin Periodontol 2019 Feb 3;46(2):170-180. Epub 2019 Feb 3.

Department of Dentistry and Oral Health, La Trobe Rural Health School, La Trobe University, Bendigo, Victoria, Australia.

Objectives: The aim of this study was to investigate the impact of periodontal disease on the domains of oral health-related quality of life (OHRQoL) of United Kingdom adults.

Methods: National representative data from the 2009 Adult Dental Health Survey, United Kingdom, were used in this study. Periodontal disease severity was measured using periodontal pocket depth and categorized into three groups: pocket depth up to 3. Read More

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http://doi.wiley.com/10.1111/jcpe.13072
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http://dx.doi.org/10.1111/jcpe.13072DOI Listing
February 2019
10 Reads

Association between periodontal disease and preterm prelabour rupture of membranes.

J Clin Periodontol 2019 Feb 3;46(2):189-196. Epub 2019 Feb 3.

Department of Obstetrics and Gynecology, Faculty of Medicine in Hradec Kralove, University Hospital in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.

Objective: Periodontal disease is a possible contributing factor to preterm delivery. The aim of this study was to compare the periodontal status of women with preterm prelabour rupture of membranes (PPROM) and women with uncomplicated singleton pregnancies.

Patients And Methods: Seventy-eight women with PPROM at gestational ages between 24 + 0 and 36 + 6 weeks and 77 healthy women with uncomplicated pregnancies, matched for gestational age at sampling without preterm birth, were included in this study. Read More

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http://dx.doi.org/10.1111/jcpe.13067DOI Listing
February 2019
2 Reads

The depth of the implant mucosal tunnel modifies the development and resolution of experimental peri-implant mucositis: A case-control study.

J Clin Periodontol 2019 Feb 7;46(2):248-255. Epub 2019 Feb 7.

Department of Periodontology, Faculty of Dentistry, Hong Kong University, Hong Kong, SAR, China.

Background: Resolution and prevention of peri-implant mucositis are a key in preventing peri-implantitis. This case-control study aims to assess the modifying effect of a deep mucosal tunnel (DMT) on the induction and resolution phases of experimental peri-implant mucositis.

Methods: Nineteen subjects with a tissue level implant were assigned to cases (DMT, depth ≥3 mm) or controls (shallow mucosal tunnel ≤1 mm, SMT). Read More

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http://dx.doi.org/10.1111/jcpe.13066DOI Listing
February 2019
3 Reads

Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signaling pathway.

J Clin Periodontol 2019 Jan 13. Epub 2019 Jan 13.

The State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Sichuan, People's Republic of China.

Aim: In this study, we investigate the mechanistic link between rheumatoid arthritis (RA) and periodontitis to identify a novel target (cathepsin K; Ctsk) for the treatment of comorbid periodontitis and RA.

Methods: An experimental model of periodontitis with arthritis was established in DBA/1 mice. We then tested the effect of BML-244, a specific inhibitor of Ctsk, by quantifying several inflammatory markers of TLR9 signaling both in vivo and in vitro. Read More

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http://doi.wiley.com/10.1111/jcpe.13060
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http://dx.doi.org/10.1111/jcpe.13060DOI Listing
January 2019
4 Reads
4.010 Impact Factor

New insights in the link between malocclusion and periodontal disease.

J Clin Periodontol 2019 Feb;46(2):144-159

Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University Medicine Greifswald, Greifswald, Germany.

Aim: We aimed to investigate associations between malocclusions and periodontal disease by comparing it to that of smoking in subjects recruited from the population-based cross-sectional study "Study of Health in Pomerania."

Materials And Methods: Sagittal intermaxillary relationship, variables of malocclusion and socio-demographic parameters of 1,202 dentate subjects, 20-39 years of age, were selected. Probing depth (PD) and attachment loss (AL) were assessed at four sites by tooth in a half-mouth design. Read More

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http://doi.wiley.com/10.1111/jcpe.13062
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http://dx.doi.org/10.1111/jcpe.13062DOI Listing
February 2019
4 Reads

Traumatic occlusion aggravates bone loss during periodontitis and activates Hippo-YAP pathway.

J Clin Periodontol 2019 Jan 10. Epub 2019 Jan 10.

The State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Sichuan, People's Republic of China.

Aim: This study aimed at exploring changes in YAP expression and their effect on periodontitis combined with traumatic occlusion (TO).

Materials And Methods: BALB/cJ mice were used to establish a periodontitis model by local administration of Porphyromonas gingivalis (P.g, ATCC 33277), and a TO model by occlusal elevation (OE) using composite resin bonding on the bilateral maxillary molar. Read More

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http://doi.wiley.com/10.1111/jcpe.13065
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http://dx.doi.org/10.1111/jcpe.13065DOI Listing
January 2019
6 Reads
4.010 Impact Factor

Biologic modelling of periodontal disease progression.

J Clin Periodontol 2019 Feb;46(2):160-169

Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, Kentucky.

Aim: To investigate the synergistic role of biologic markers from saliva, serum and plaque in modelling periodontitis disease progression.

Material And Methods: This longitudinal study evaluated characteristics of disease progression in 114 patients with generalized moderate to severe periodontitis. The primary outcome was detection of sites with progressing attachment loss sites over 6 months in patients who received scaling and root planing or oral hygiene only. Read More

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http://doi.wiley.com/10.1111/jcpe.13064
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http://dx.doi.org/10.1111/jcpe.13064DOI Listing
February 2019
9 Reads

Incorporating antibiotics into platelet-rich fibrin: A novel antibiotics slow-release biological device.

J Clin Periodontol 2019 Feb;46(2):241-247

Department of Periodontology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: The aim of the present in vitro study was to explore the possibility of using platelet-rich fibrin (PRF) as a local sustained released device for antibiotics.

Materials And Methods: Platelet-rich fibrin was prepared with the addition of antibiotics (5 mg/ml metronidazole; 150 mg/ml clindamycin; 1 mU/ml penicillin) or saline prior to centrifugation, while collagen sponges served as control. PRFs anti-bacterial properties were examined in an anti-biogram assay with Staphylococcus aureus or Fusobacterium nucleatum at different time intervals after PRF preparation. Read More

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http://dx.doi.org/10.1111/jcpe.13063DOI Listing
February 2019
1 Read

The effectiveness of immediate implant placement for single tooth replacement compared to delayed implant placement: a systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 9. Epub 2019 Jan 9.

Ghent University, Faculty of Medicine and Health Sciences, Dental School, Department of Periodontology and Oral Implantology, C. Heymanslaan 10, B-9000, Ghent, Belgium.

Aim: To compare immediate (IIP) to delayed single implant placement (DIP, ≥ 3 months post-extraction) in terms of implant survival (primary outcome), surgical, clinical, aesthetic, radiographic and patient-reported outcomes (secondary outcomes).

Materials And Methods: Two reviewers independently performed an electronic search in Pubmed, Web of Science, Embase and Cochrane and a hand search to identify eligible studies up to May 2018. Only Randomized Controlled Trials (RCTs) and Non-Randomized Controlled Studies (NRSs) comparing IIP to DIP with at least one year of follow-up were selected for a qualitative analysis and meta-analysis. Read More

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http://dx.doi.org/10.1111/jcpe.13054DOI Listing
January 2019

Mesenchymal Stem Cells and Biologic Factors leading to Bone Formation.

J Clin Periodontol 2019 Jan 9. Epub 2019 Jan 9.

School of Dentistry, University of Queensland, Brisbane, Queensland, Australia.

Background: Physiological bone formation and bone regeneration occurring during bone repair can be considered distinct but similar processes. Mesenchymal stem cells and associated biologic factors are crucial to both bone formation and bone regeneration.

Aim: To perform a narrative review of the current literature regarding the role of mesenchymal stem cells and biologic factors in bone formation with the aim of discussing the clinical relevance of in vitro and in vivo animal studies. Read More

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http://dx.doi.org/10.1111/jcpe.13053DOI Listing
January 2019
1 Read

Efficacy of lateral bone augmentation prior to implant placement: A systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 9. Epub 2019 Jan 9.

Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.

Aim: The aim of the current systematic review was to critically appraise evidence from randomized and prospective non-randomized comparative clinical trials about the efficacy of lateral bone augmentation prior to implant placement and their outcome regarding bone-width gain.

Material And Methods: Eight databases were searched until May 2018 for randomized and prospective non-randomized comparative trials on lateral bone augmentation prior to implant placement. After elimination of duplicate studies, data extraction and risk-of-bias assessment according to the Cochrane guidelines, random-effects meta-analyses of Mean Differences (MD) or Relative Risks (RR) and their 95% CIs were performed, followed by subgroup, meta-regression, and sensitivity analyses. Read More

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http://dx.doi.org/10.1111/jcpe.13052DOI Listing
January 2019

Long-term effectiveness of maxillary sinus floor augmentation A systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 9. Epub 2019 Jan 9.

Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Aim: To assess the long-term effectiveness (≥5 years) of maxillary sinus floor augmentation (MSFA) procedures applying the lateral window technique and to determine possible differences in outcome between simultaneous and delayed implant placement, partially and fully edentulous patients, and grafting procedures.

Materials And Methods: MEDLINE (1950-May 2018), EMBASE (1966-May 2018) and Cochrane Central Register of Controlled Trials (1800-May 2018) were searched. Inclusion criteria were prospective studies with follow-up ≥5 years and a residual bone height ≤6 mm. Read More

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http://dx.doi.org/10.1111/jcpe.13055DOI Listing
January 2019

The critical interplay between bone resorbing and bone forming cells.

J Clin Periodontol 2019 Jan 9. Epub 2019 Jan 9.

Department of Odontology, Division of Molecular Periodontology, Umeå University, SE-901 85, Umeå, Sweden.

Aim: In this article, the interplay between bone resorbing and bone forming cells is reviewed.

Method: This review examines the literature comprehensively on the interaction between bone resorption and bone formation RESULTS: Coupling between bone resorption and bone formation refers to the process within basic multicellular units, in which osteoclastic bone resorption is met by the differentiation of osteoblasts and their bone-forming activity. There are many possible signalling molecules that contribute to coupling at the asynchronously working remodelling sites throughout our skeleton. Read More

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http://dx.doi.org/10.1111/jcpe.13051DOI Listing
January 2019

Effect of Alveolar Ridge Preservation Interventions Following Tooth Extraction: A Systematic Review and Meta-Analysis.

J Clin Periodontol 2019 Jan 9. Epub 2019 Jan 9.

Department of Periodontology, Universidad Complutense de Madrid (Spain).

Purpose: The aim of this systematic review was to critically analyze the available evidence on the effect of different modalities of alveolar ridge preservation (ARP) as compared to tooth extraction alone in function of relevant clinical, radiographic and patient-centered outcomes.

Material And Methods: A comprehensive search aimed at identifying pertinent literature for the purpose of this review was conducted by two independent examiners. Only randomized clinical trials (RCTs) that met the eligibility criteria were selected. Read More

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http://doi.wiley.com/10.1111/jcpe.13057
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http://dx.doi.org/10.1111/jcpe.13057DOI Listing
January 2019
2 Reads

Bone grafts: which is the ideal biomaterial?

J Clin Periodontol 2019 Jan 9. Epub 2019 Jan 9.

Industrie Biomediche Insubri SA, Via Cantonale 67, 6805, Mezzovico-Vira, Switzerland.

Bovine xenograft materials, followed by synthetic biomaterials, which unfortunately still lack documented predictability and clinical performance, dominate the market for the cranio-maxillofacial area. In Europe, new stringent regulations are expected to further limit the allograft market in the future AIM: Within this narrative review, we discuss possible future biomaterials for bone replacement.

Scientific Rationale For Study: Although the bone graft (BG) literature is overflooded, only a handful of new BG substitutes are clinically available. Read More

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http://dx.doi.org/10.1111/jcpe.13058DOI Listing
January 2019
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The use of bioactive factors to enhance bone regeneration. A narrative review.

J Clin Periodontol 2019 Jan 8. Epub 2019 Jan 8.

Centre Immuno-Biology & Regenerative Medicine & Centre for Oral Clinical Research (COCR), Institute of Dentistry, Barts & The London School of Medicine & Dentistry, Queen Mary University of London (QMUL), London, UK.

Aim: This review critically appraises the available knowledge on the pre-clinical and clinical use of bioactive factors for bone regeneration in the cranial and maxillo-facial area.

Materials And Methods: The use of growth factors, amelogenins and autologous platelet concentrates (APCs) for bone regeneration was reviewed in a systematic manner. More specifically, preclinical and clinical studies on ridge preservation, alveolar ridge augmentation, regeneration of peri-implant defects and sinus augmentation models were considered. Read More

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http://dx.doi.org/10.1111/jcpe.13048DOI Listing
January 2019
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Cell therapy for orofacial bone regeneration: a systematic review and meta-analysis.

J Clin Periodontol 2019 Jan 9. Epub 2019 Jan 9.

Department of Clinical Dentistry, Center for Clinical Dental Research, University of Bergen, Bergen, Norway.

Aim: The objective of the present review was to answer the focused question: what is the effect of cell therapy in terms of orofacial bone regeneration compared to grafting with only biomaterial scaffolds and/or autogenous bone?

Methods: Electronic databases were searched for relevant controlled clinical and pre-clinical (large-animal) studies. Separate meta-analyses of quantitative data regarding histological or radiographic new bone formation were performed.

Results: Forty-seven eligible clinical and 57 pre-clinical studies were included. Read More

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http://dx.doi.org/10.1111/jcpe.13049DOI Listing
January 2019
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Osteoimmunology: inflammatory osteolysis and regeneration of the alveolar bone.

Authors:
Reinhard Gruber

J Clin Periodontol 2019 Jan 9. Epub 2019 Jan 9.

Department of Oral Biology, Medical University of Vienna, Austria.

Aim: Osteoimmunology covers the cellular and molecular mechanisms responsible for inflammatory osteolysis that culminate in the degradation of alveolar bone. Osteoimmunology also focuses on the interplay of immune cells with bone cells during bone remodeling and regeneration. The aim of this review is to provide insights into how osteoimmunology affects alveolar bone health and disease. Read More

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http://dx.doi.org/10.1111/jcpe.13056DOI Listing
January 2019

Salivary S100 proteins screen periodontitis among Korean adults.

J Clin Periodontol 2019 Feb 28;46(2):181-188. Epub 2019 Jan 28.

Department of Preventive and Social Dentistry, Seoul National University School of Dentistry, Seoul, Korea.

Aim: This study aims to evaluate the association of salivary S100A8 and A9 proteins with periodontitis and its screening ability for periodontitis cross-sectionally.

Material And Methods: We selected 326 participants from the Yangpyeong Cohort: 218 participants with periodontitis and 108 participants without periodontitis. Stage II-IV periodontitis according to the modification of new international classification of periodontitis was considered as periodontitis. Read More

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http://dx.doi.org/10.1111/jcpe.13059DOI Listing
February 2019
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Immunization with cell-free-generated vaccine protects from Porphyromonas gingivalis-induced alveolar bone loss.

J Clin Periodontol 2019 Feb 31;46(2):197-205. Epub 2019 Jan 31.

Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida.

Introduction: Periodontal diseases (PD) are complex oral inflammatory diseases initiated by keystone bacteria such as Porphyromonas gingivalis. A vaccine for PD is desirable as clinical treatment involves protracted maintenance strategies aimed to retain dentition. Although prior immunization approaches targeting P. Read More

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http://doi.wiley.com/10.1111/jcpe.13047
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http://dx.doi.org/10.1111/jcpe.13047DOI Listing
February 2019
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An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis.

J Clin Periodontol 2019 Jan;46(1):6-11

Forsyth Institute, Cambridge, Massachusetts.

Background: Historically, inflammatory periodontal diseases (gingivitis and periodontitis) have been recognized as being primarily of bacterial origin. Bacteria are necessary for disease development, but the presence of specific bacteria does not guarantee progression to periodontitis. Periodontitis is a multifactorial disease; specific bacteria are associated with disease, but may not be the target of treatment. Read More

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http://dx.doi.org/10.1111/jcpe.13046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357965PMC
January 2019

In Memoriam, Steven Offenbacher (1950-2018).

J Clin Periodontol 2019 Jan;46(1):4-5

Department of Periodontology, University of Athens, Athens, Greece.

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http://dx.doi.org/10.1111/jcpe.13043DOI Listing
January 2019
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Genetic and environmental contributions to the association between mood disorder and periodontal disease: A cross-sectional study among female twins in the UK.

J Clin Periodontol 2019 Jan;46(1):40-50

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.

Aim: This study aimed to investigate the factors associated with periodontal traits considering genetic and environmental background in predominantly older female twins.

Methods: This was a cross-sectional study using self-reported questionnaires for periodontal traits in TwinsUK. Age-adjusted and age-stratified multivariate analyses were conducted for all twins. Read More

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http://dx.doi.org/10.1111/jcpe.13045DOI Listing
January 2019
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Impact of diabetes on clinical periodontal outcomes following non-surgical periodontal therapy.

J Clin Periodontol 2019 Feb 20;46(2):206-217. Epub 2019 Jan 20.

Department of Periodontics and Dental Hygiene, University of Texas Health Science Center at Houston, Houston, Texas.

Aim: This systematic review aimed to evaluate the impact of diabetes mellitus on clinical outcomes of non-surgical periodontal therapy.

Materials And Methods: Searches were conducted in electronic databases to screen studies published from January 1960 to August 2018. The included studies had at least two groups of patients: chronic periodontitis only (P) or both diabetes and chronic periodontitis (DMP). Read More

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http://dx.doi.org/10.1111/jcpe.13044DOI Listing
February 2019
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Dysregulation of human miRNAs and increased prevalence of HHV miRNAs in obese periodontitis subjects.

J Clin Periodontol 2019 Jan;46(1):51-61

Department of Periodontics, University of Illinois at Chicago, Chicago, Illinois.

Aim: To evaluate human and herpesvirus-encoded microRNA (miRNA) expression in healthy and diseased gingiva of obese and non-obese subjects and compare the impact of localized and systemic inflammation on human miRNA profiles.

Material And Methods: Healthy and inflamed gingival biopsies were collected from obese and non-obese subjects. Human and herpesvirus miRNA expression was quantified using quantitative PCR. Read More

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http://dx.doi.org/10.1111/jcpe.13040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340734PMC
January 2019
7 Reads

Is there an association between depression and periodontitis? A birth cohort study.

J Clin Periodontol 2019 Jan;46(1):31-39

Graduate Program in Dentistry, Federal University of Pelotas, Pelotas, Brazil.

Aim: To investigate the association between depression and periodontitis among adults enrolled in the 1982 Pelotas Birth Cohort, Brazil.

Materials And Methods: Major depressive episode (MDE) and severity of depressive symptoms obtained in 2012 were considered the exposure of this study. In 2013, periodontitis, the outcome of interest, was clinically assessed and two different case definitions were used: the CDC/AAP and a combination of clinical attachment loss (CAL) and bleeding on probing (BOP) simultaneously. Read More

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http://dx.doi.org/10.1111/jcpe.13039DOI Listing
January 2019
9 Reads

Time between recall visits and residual probing depths predict long-term stability in patients enrolled in supportive periodontal therapy.

J Clin Periodontol 2019 Feb 28;46(2):218-230. Epub 2019 Jan 28.

Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.

Aim: To relate the time between recall visits and residual periodontal probing depths (PPDs) to periodontal stability in patients enrolled in supportive periodontal therapy (SPT).

Materials And Methods: Retrospective data on residual PPDs from 11,842 SPT visits were evaluated in SPT patients at the Medi School of Dental Hygiene (MSDH), Bern, Switzerland, 1985-2011. A residual PPD-based algorithm was developed to compute SPT intervals with no expected change of residual PPD. Read More

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http://doi.wiley.com/10.1111/jcpe.13041
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http://dx.doi.org/10.1111/jcpe.13041DOI Listing
February 2019
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Prediction models for the incidence and progression of periodontitis: A systematic review.

J Clin Periodontol 2018 Dec 25;45(12):1408-1420. Epub 2018 Nov 25.

Australian Research Centre for Population Oral Health, the University of Adelaide, Adelaide, South Australia, Australia.

Aims: To comprehensively review, identify and critically assess the performance of models predicting the incidence and progression of periodontitis.

Methods: Electronic searches of the MEDLINE via PubMed, EMBASE, DOSS, Web of Science, Scopus and ProQuest databases, and hand searching of reference lists and citations were conducted. No date or language restrictions were used. Read More

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http://doi.wiley.com/10.1111/jcpe.13037
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http://dx.doi.org/10.1111/jcpe.13037DOI Listing
December 2018
18 Reads