7,543 results match your criteria Journal of Clinical Neuroscience[Journal]


Effectiveness of an on-body lifting aid (HAL® for care support) to reduce lower back muscle activity during repetitive lifting tasks.

J Clin Neurosci 2019 Feb 14. Epub 2019 Feb 14.

Department of General and Trauma Surgery, BG University Hospital, Bochum, Germany.

The Hybrid Assistive Limb Lumbar Type (HAL) is an active exoskeleton that provides motion according to the wearer's voluntary drive. It was developed to support back muscles during repetitive lifting tasks. The purpose of this paper was to determine if the myoelectric activity of the back muscles is reduced or altered when using the HAL and to investigate a possible influence of its use on the cardiovascular system. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.038DOI Listing
February 2019

Allicin attenuates early brain injury after experimental subarachnoid hemorrhage in rats.

J Clin Neurosci 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurosurgery, Jinling Hospital, School of Medicine, Southern Medical University (Guangzhou), 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China; Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. Electronic address:

Early Brain Injury, rather than Cerebral Vasospasm, has been demonstrated to be more important for patients with Subarachnoid hemorrhage. It is considered that allicin can make sense in a wide range of pharmacological areas and can be taken as a therapeutic method in many pathologic situations. We have explored the potential effect of allicin and possible mechanisms in Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.024DOI Listing
February 2019

Letter to the editor regarding the manuscript "Efficacy, tolerability, and blood concentration of zonisamide in daily clinical practice".

J Clin Neurosci 2019 Feb 14. Epub 2019 Feb 14.

Division of Nephrology, Hypertension and Kidney Transplantation, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1016/j.jocn.2019.01.035DOI Listing
February 2019

Effect of dosage reduction on peripheral blood lymphocyte count in patients with multiple sclerosis receiving long-term fingolimod therapy.

Authors:
Kazuya Takahashi

J Clin Neurosci 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurology, Hokuriku Brain and Neuromuscular Disease Center, National Hospital Organization Iou Hospital, Kanazawa, Japan. Electronic address:

Of the 19 cases of fingolimod-associated progressive multifocal leukoencephalopathy (PML) reported worldwide by the end of 2017, 4 cases were from Japan. This may indicate that fingolimod sensitivity is higher in the Japanese population than in the western population because the fingolimod dosage used for the prevention of multiple sclerosis (MS) is the same in both populations. Therefore, the laboratory data of nine patients with MS receiving fingolimod treatment for more than 2 years were retrospectively collected. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.034DOI Listing
February 2019

Prostatic nerve subtypes independently predict biochemical recurrence in prostate cancer.

J Clin Neurosci 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, Division of Urology, University of Melbourne, Royal Melbourne Hospital, Australia; Urology Unit, Department of Surgery, Peninsula Health, Australia; Australian Prostate Cancer Research Centre Epworth, Richmond, Australia.

Objective: To describe nerve subtypes involved by perineural invasion (PNI) in prostate cancer and their relationship with clinicopathological parameters and recurrence risk.

Methods: 141 prostatectomy specimens from men with localized prostate cancer and known perineural invasion were analyzed. Index tumor blocks were stained for perineural invasion and sympathetic/parasympathetic markers. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.052DOI Listing
February 2019

Superselective methohexital challenge prior to intracranial endovascular embolization.

J Clin Neurosci 2019 Feb 13. Epub 2019 Feb 13.

Stanford University, Department of Neurology, 300 Pasteur Drive, Stanford 94305, CA, United States.

Pharmacologic provocative testing (PT) and intraoperative neurophysiologic monitoring (IONM) both mitigate and predict risks associated with endovascular embolization procedures. We present a series of patients undergoing endovascular intracranial embolization predominantly for AVMs both under general anesthesia and awake with the use of IONM. We reviewed our database to identify all patients undergoing endovascular procedures between January 1, 2014 and January 1, 2016. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.051DOI Listing
February 2019

CyberKnife radiosurgery for acoustic neuromas: Tumor control and clinical outcomes.

J Clin Neurosci 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States. Electronic address:

Fractionated CyberKnife radiosurgery (CKRS) treatment for acoustic neuromas may reduce the risk of long-term radiation toxicity to nearby critical structures compared to that of single-fraction radiosurgery. However, tumor control rates and clinical outcomes after CKRS for acoustic neuromas are not well described. We retrospectively reviewed all acoustic neuroma patients treated with CKRS (2004-2011) in a prospectively maintained clinical and radiographic database. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.046DOI Listing
February 2019

Medical and endovascular treatments of symptomatic intracranial stenosis. A Bayesian network meta-analysis.

J Clin Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurology, "G. Jazzolino" Hospital, Vibo Valentia, Italy.

Intracranial stenosis is a well-established stroke risk factor with an increase of stroke recurrence or TIA up to 12.6% at 1 year. Treatments are different: medical and endovascular. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.040DOI Listing
February 2019

Occipital artery to upper posterior circulation bypass through the presigmoid approach in revascularization of the posterior circulation: An anatomical study.

J Clin Neurosci 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurosurgery, Affiliated Hospital of Logistics University of Chinese People's Armed Police Forces, Tianjin 30052, China. Electronic address:

We describe a novel extracranial (EC)-to-intracranial (IC) bypass technique between the occipital artery and upper posterior circulation (UPC) for revascularization of the posterior circulation through the presigmoid approach. Five formalin-fixed human heads were examined to demonstrate the detailed anatomy of the occipital artery and UPC and illustrate the step-by-step bypass procedure. The occipital artery, a branch of the external carotid artery, can be anastomosed to the P2/P3 segment of the posterior cerebral artery and S1/S2 segments of the superior cerebellar artery as an alternative to EC bypass donor segments for treatment of affection requiring revascularization. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.020DOI Listing
February 2019

Subtraction of arterial spin-labeling magnetic resonance perfusion images acquired at dual post-labeling delay: Potential for evaluating cerebral hyperperfusion syndrome following carotid endarterectomy.

J Clin Neurosci 2019 Feb 6. Epub 2019 Feb 6.

Department of Cerebrovascular Disease, Kyushu Rosai Hospital, Japan.

Arterial spin-labeling magnetic resonance perfusion imaging is a promising tool for the diagnosis of cerebral hyperperfusion syndrome after carotid endarterectomy. However, arterial spin-labeling with a single post-labeling delay has been reported to show a higher incidence of increased arterial spin-labeling signals in the bilateral hemisphere, probably due to a shortening of the arterial transit time or an arterial transit artifact caused by intravascular stagnant magnetically-labeled spin. To overcome these shortcomings, we used two post-labeling delay settings (1. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.044DOI Listing
February 2019

A novel rescue therapy for cerebral vasospasm: Cisternal Nimodipine application via stereotactic catheter ventriculocisternostomy.

J Clin Neurosci 2019 Feb 5. Epub 2019 Feb 5.

Department of Stereotactic and Functional Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany.

Delayed Cerebral Infarction (DCI) due to Cerebral Vasospasm (CVS) is an important contributor to poor outcome after aneurysmal subarachnoid haemorrhage (aSAH). Despite established risk factors CVS and DCI are unpredictable at the individual patient level. Efficient treatments are lacking. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.039DOI Listing
February 2019
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Optimization and evaluation of an in vitro model of PEG-mediated fusion of nerve cell bodies.

J Clin Neurosci 2019 Feb 5. Epub 2019 Feb 5.

Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. Electronic address:

Polyethylene glycol (PEG) is a cell membrane fusogen (de StGroth et al., 1980; Hoehn et al., 1978 [2]; Pontecorvo et al. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.037DOI Listing
February 2019
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Transpedicular lag screw placement in traumatic cervical spondylolisthesis: Case report and systematic review of the literature.

J Clin Neurosci 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. Electronic address:

Traumatic spondylolisthesis of C2-C3 is an unstable fracture. Posterior fixation techniques can be employed with intraoperative navigation, however this tool is not available to all spine surgeons. Furthermore, the evidence for posterior surgical stabilization of C2, while adhering to motion preservation principles is currently unknown. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.036DOI Listing
February 2019

Platelet-to-neutrophil ratio is a prognostic marker for 90-days outcome in acute ischemic stroke.

J Clin Neurosci 2019 Feb 5. Epub 2019 Feb 5.

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

To investigate the prognostic value of platelet-to-neutrophil ratio (PNR) in acute ischemic stroke (AIS) patients. In this study, a total of 400 AIS patients were included. Demographic, clinical, laboratory data were collected on admission, and PNR was calculated according to platelet and neutrophil counts on admission. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.028DOI Listing
February 2019
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Outcome and prognostic factors for atypical meningiomas after first recurrence.

J Clin Neurosci 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Tiantan Xili 6, Dongcheng District, Beijing 100050, PR China. Electronic address:

Atypical meningioma (AM) tends to be tumor with high rates of recurrence and mortality. In this retrospective study, 131 recurrent AM patients underwent AM surgery in Beijing Tiantan Hospital between January 2008 and December 2015. Of the 131 cases collected, 61 were male (46. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.032DOI Listing
February 2019
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Reply to 'Moyamoya vasculopathy with anti-SCL-70 antibodies: A case report and review of the literature'.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Goethe University, Division of Rheumatology, University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.jocn.2019.01.043DOI Listing
February 2019

The clinical characteristics and cognitive features of mild cognitive impairment in Parkinson's disease and the analysis of relevant factors.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Department of Neurology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Neuroscience Institute, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, PR China. Electronic address:

The purpose of this work is to investigate the clinical characteristics, cognitive impairment features, and subgroup types of Parkinson's disease (PD) subjects with mild cognitive impairment (PD-MCI) in the Chinese population and to analyze relevant risk factors for PD-MCI. A total of 234 non-dementia PD subjects were collected. Standardized neuropsychological assessments of overall cognitive level and four cognitive domains (memory, executive function, attention and visuospatial function) were performed using MDS Task Force diagnostic criteria for PD-MCI. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.021DOI Listing
February 2019
2 Reads

Posterior cervical fusion utilizing cages placed bilaterally in the facets for the treatment of the upper cervical adjacent segment disease in the elderly.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Clinical Faculty, Department of Neurosurgery at UCSF Medical Center, Saint Francis Memorial Hospital, San Francisco, CA, United States.

This is a retrospective review of 24 elderly patients with upper cervical adjacent segment disease (ASD) after anterior cervical discectomy and fusion (ACDF), treated with posterior cervical fusion (PCF) and stabilized with cages placed bilaterally in the facets. Eight out of 24 patients had PCF with laminectomy (PCLF). Length of stay for PCF alone cohort was 30 ± 11 h, operative time was 44 ± 11 min and estimated blood loss was 46 ± 26 cc. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.018DOI Listing
February 2019
1 Read

Basilar artery perforator aneurysms: Report of 9 cases and review of the literature.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Neuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Germany; Medical Faculty, University Duisburg-Essen, Germany.

Basilar perforator artery aneurysms (BAPA's) are an under-recognised cause of sub-arachnoid haemorrhage (SAH). We present our single centre experience of BAPA's and review of the literature. We performed a retrospective review of our prospectively maintained database to identify all BAPA's that presented acute SAH between February 2009 and February 2018. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.026DOI Listing
February 2019
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Neuromodulation of autism spectrum disorders using vagal nerve stimulation.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Cornwall Partnership NHS Foundation Trust, Threemilestone Industrial Estate, Truro TR4 9LD, UK; Exeter Medical School, Knowledge Spa, Royal Cornwall Hospital, Truro TR1 3HD, UK. Electronic address:

Influential theories propose an important role for the autonomic nervous system in social behaviour and emotion regulation. Difficulties with these capabilities occur in autism spectrum disorders (ASD). Vagus nerve stimulation (VNS) is a neuromodulation technique that stimulates autonomic pathways by means of an electrode implanted around the left vagus nerve in the neck. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.042DOI Listing
February 2019
1 Read

Resection of a cerebellar hemangioblastoma via a minimally invasive tubular approach.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Hemangioblastomas are rare benign, highly vascularized tumors occurring in the cerebellum and the spinal cord. They often develop tumor-associated cysts multiple times the size of the solid part of the tumor. Patients with von Hippel-Lindau (VHL) disease typically exhibit multiple tumors with the need of repeated surgeries during their lifetime. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.045DOI Listing
February 2019

Pseudoaneurysm presenting around polytetrafluoroethylene fiber following microvascular decompression: A case report and literature review.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Department of Neurosurgery, Sapporo Medical University, Japan.

We report the first case of pseudoaneurysm associated with polytetrafluoroethylene fiber used in microvascular decompression (MVD). A 62-year-old female who had undergone MVD for hemifacial spasm 30 years ago presented with a 4-month history of progressive facial palsy. Computed tomography angiography revealed a large thrombosed aneurysm originating from the right posterior inferior cerebellar artery and having a mass effect upon the pons. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.041DOI Listing
February 2019

Asymptomatic moderate carotid artery stenosis with intraplaque hemorrhage: Progression of degree of stenosis and new ischemic stroke.

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan.

Carotid intraplaque hemorrhage (IPH) plays a critical role in the progression of carotid atherosclerotic disease. IPH was associated with high intensity signal (HIS) in the plaque on Maximum intensity projection (MIP) images from routine three dimensional magnetic resonance imaging (3D-TOF MRA). The aim of this study was to evaluate the relationships among HIS, new ipsilateral ischemic stroke and a progression rate in carotid plaques with moderate stenosis. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.033DOI Listing
February 2019
1 Read

Peripheral BDNF/TrkB protein expression is decreased in Parkinson's disease but not in Essential tremor.

J Clin Neurosci 2019 Feb 2. Epub 2019 Feb 2.

Department of Neurology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, 29 Xinglong Alley, 213003 Changzhou, China.

BDNF-to-TrkB signaling pathways plays an important role in the long-term maintenance of the nigrostriatal system and that its deficiency may contribute to the onset and progression of Parkinson's disease (PD). To our knowledge this is the first study to investigate the expression of the brain-derived neurotrophic factor (BDNF) and phosphorylation status of TrkB in peripheral blood lymphocytes of 28 PD and 28 Essential tremor (ET) patients and 28 healthy controls using western blot analysis. Compared with controls, no significant difference of BDNF and total and phosphorylated TrkB levels were observed in ET, whereas BDNF and phosphorylated TrkB levels were significantly decreased in the PD groups (p < 0. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.017DOI Listing
February 2019
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Surgical technique for the protection of the cervical sympathetic trunk in anterolateral oblique corpectomy: A new cadaveric demonstration.

J Clin Neurosci 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurosurgery, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey.

The cervical oblique corpectomy (OC) approach has the advantages of no grafting or instrumentation necessities and theoretically maintains natural neck motions. However, the risk of cervical sympathetic trunk (CST) injury and Horner's syndrome is one of the main difficulties of this demanding surgical approach. The upper necks of 3 adult human cadavers (6 sides) were dissected under a Zeiss surgical microscope. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.019DOI Listing
February 2019
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The different clinical value of susceptibility vessel sign in acute ischemic stroke patients under different interventional therapy: A systematic review and meta-analysis.

J Clin Neurosci 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, The First Affiliated Hospital of ChongQing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing, China. Electronic address:

Acute ischemic stroke (AIS) subtype, one of the most important factors for selecting therapeutic strategies, is difficult to be accurately diagnosed at admission sometimes. The magnetic susceptibility effect of deoxygenated hemoglobin in red thrombi appeared as hypointense signals in magnetic resonance imaging (MRI) scans. The prognostic value of susceptibility vessel sign (SVS) for stroke subtype, recanalization and outcomes in AIS patients will be comprehensively determined in the present study. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.002DOI Listing
January 2019
1 Read

Determining a cut-off residual tumor volume threshold for patients with newly diagnosed glioblastoma treated with temozolomide chemoradiotherapy: A multicenter cohort study.

J Clin Neurosci 2019 Jan 31. Epub 2019 Jan 31.

Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, Hong Kong, China.

Standard-of-care treatment of glioblastomas involves maximal safe resection and adjuvant temozolomide chemo-radiotherapy. Although extent of resection (EOR) is a well-known surgical predictor for overall survival most lesions cannot be completely resected. We hypothesize that in the event of incomplete resection, residual tumor volume (RTV) may be a more significant predictor than EOR. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.022DOI Listing
January 2019
1 Read

Technical considerations for generating somatosensation via cortical stimulation in a closed-loop sensory/motor brain-computer interface system in humans.

J Clin Neurosci 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurosurgery, University of Southern California, Los Angeles, CA, USA; Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Somatosensory feedback is the next step in brain computer interface (BCI). Here, we compare three cortical stimulating array modalities for generating somatosensory percepts in BCI. We compared human subjects with either a 64-channel "mini"-electrocorticography grid (mECoG; 1. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.027DOI Listing
January 2019

Implant failure of pedicle screws in long-segment posterior cervical fusion is likely to occur at C7 and is avoidable by concomitant C6 or T1 buttress pedicle screws.

J Clin Neurosci 2019 Jan 30. Epub 2019 Jan 30.

Department of Orthopedic Surgery, University of Tsukuba, Tsukuba, Japan.

The aim of this study was to investigate the incidence and characteristics of implant failure in posterior cervical long-segment fusion surgery. We retrospectively reviewed 51 cases of posterior cervical long-segment fusion surgery that used pedicle screws, lateral mass screws, or laminar screws. The cranial end of the fusion was C2 or C3, and the caudal end of the fusion was C7 or T1. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.029DOI Listing
January 2019

Therapeutic effect of repetitive transcranial magnetic stimulation on non-lesional focal refractory epilepsy.

J Clin Neurosci 2019 Jan 30. Epub 2019 Jan 30.

Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

The effects of repetitive transcranial magnetic stimulation (rTMS) on epilepsy remain unclear. This study was performed to investigate the effects of low-frequency rTMS on non-lesional focal epilepsy. This was a prospective open-label longitudinal study with four patients with multi-drug-resistant non-lesional focal epilepsy and no control group. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.025DOI Listing
January 2019
1 Read

Long term delay in onset of prevertebral hematoma following anterior cervical discectomy and fusion: A case report.

J Clin Neurosci 2019 Jan 28. Epub 2019 Jan 28.

Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States. Electronic address:

Post-operative hematoma following anterior cervical discectomy and fusion (ACDF) is an uncommon but feared complication. Typically, these complications present in the immediate post-operative period. We present a case of a 51 year-old woman who underwent a C4-5 ACDF for left sided radicular pain. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.12.031DOI Listing
January 2019

Low levels of vitamin D and the relationship between vitamin D and Th2 axis-related cytokines in neuromyelitis optica spectrum disorders.

J Clin Neurosci 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Objective: The impact of vitamin D have been studied in neuroinflammation disorders, and as the newly discovered Th2-related cytokines, IL-25, IL-31 and IL-33 may also play important roles in the lesions of neuromyelitis optica spectrum disorders (NMOSD). This study sought to investigate the clinical profiles of vitamin D and Th2 axis-related cytokines and their relationships in patients with NMOSD.

Methods: Eighty-four NMOSD patients and 84 healthy controls (HC) were evaluated for serum levels of the total vitamin D [25(OH)D], 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] by means of high performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS). Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.024DOI Listing
January 2019

Fusion rate following three- and four-level ACDF using allograft and segmental instrumentation: A radiographic study.

J Clin Neurosci 2019 Jan 25. Epub 2019 Jan 25.

Department of Neurosurgery, Rush University Medical Center, Chicago, IL, USA.

Cervical spine degenerative pathologies remain one of the most common spinal conditions treated by spine surgeons worldwide. Surgery is recommended in all patients with symptomatic cervical spinal stenosis with either moderate to severe myelopathy, degeneration, or refractory radiculopathy. As the number of levels increases the potential for complications associated with anterior surgery can be significant, especially dysphagia and pseudarthrosis. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.040DOI Listing
January 2019
2 Reads

High resolution vessel wall MR imaging in prestenotic intracranial atherosclerotic disease.

J Clin Neurosci 2019 Jan 22. Epub 2019 Jan 22.

Department of Radiology, Division of Neuroradiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA. Electronic address:

Vessel wall MR imaging (VWI) may be able to highlight vulnerable intracranial atherosclerosis with vessel wall enhancement thereby serving as a biomarker for symptomatic prestenotic intracranial atherosclerotic disease. We present a case of intracranial hemorrhage presumably due to intracranial atherosclerotic disease (ICAD) identified by VWI and silent on lumen-based imaging modalities. A 66-year-old female presented with sudden onset headache and dysarthria. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.008DOI Listing
January 2019
3 Reads

Hyperosmotic intraventricular drug delivery of DV1 in the management of intracranial metastatic breast cancer in a mouse model.

J Clin Neurosci 2019 Jan 21. Epub 2019 Jan 21.

Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pharmacology, Upstate Medical University, State University of New York (SUNY), 750 Adams Street, Syracuse, NY 13210, USA.

Advances in therapies for breast cancer with cerebral metastases has been slow, despite this being a common diagnosis, due to limited drug delivery by the blood brain barrier. Improvements in drug delivery for brain metastasis to target the metastases and bypass the blood brain barrier are necessary. In our study, we delivered an inhibitor of chemokine receptor 4 by convection enhanced delivery in a hyperosmotic solution to prevent brain metastasis in a mouse model of metastatic breast cancer. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.003DOI Listing
January 2019
1 Read
1.318 Impact Factor

Stereotactic radiosurgery and fractionated radiotherapy for spinal arteriovenous malformations - A systematic review of the literature.

J Clin Neurosci 2019 Jan 21. Epub 2019 Jan 21.

Northwestern University Feinberg School of Medicine, Department of Neurological Surgery, Chicago, IL, United States; Northwestern University Feinberg School of Medicine, Department of Radiology, Chicago, IL, United States. Electronic address:

Spinal arteriovenous malformations (AVMs) comprise a group of complex vascular lesions whose treatment with microsurgery or transarterial embolization can be challenging. Stereotactic radiosurgery is a well-established treatment for intracranial AVMs, and spinal radiosurgery and fractionated radiotherapy are common treatments for spinal tumors of both primary and metastatic origin. The use of radiosurgery and fractionated radiotherapy for the treatment of spinal arteriovenous malformations, however, has been infrequently reported. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.12.014DOI Listing
January 2019

Glutamate transporter gene polymorphisms and obsessive-compulsive disorder: A case-control association study.

J Clin Neurosci 2019 Jan 17. Epub 2019 Jan 17.

Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói, Brazil. Electronic address:

The etiology of obsessive-compulsive disorder (OCD) is largely unknown, but family, twin, neuroimaging, and pharmacological studies suggest that glutamatergic system plays a significant role on its underlying pathophysiology. We performed an association analysis of six Single Nucleotide Polymorphisms (SNPs) within SLC1A1 gene (rs12682807, rs2075627, rs3780412, rs301443, rs301430, rs301434) in a group of 199 patients and 200 healthy controls. Symptom profiles were evaluated using the Florida Obsessive-Compulsive Inventory (FOCI) and the Obsessive-Compulsive Inventory-Revised (OCI-R). Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.009DOI Listing
January 2019
2 Reads

The effect of length of follow-up on substantial clinical benefit thresholds in patients undergoing surgery for cervical degenerative myelopathy.

J Clin Neurosci 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurosurgery, Albany Medical College, Albany, NY, United States. Electronic address:

Patient-reported outcome measures are increasingly used to access pain, disability, physical function, and mental status to quantify effectiveness of surgical intervention in cervical myelopathy, yet each score has little meaning without established thresholds linked to clinical benefit. We set out to develop thresholds for substantial clinical benefit (SCB) in patients undergoing surgery for cervical myelopathy and to evaluate the effect of length of follow-up on SCB thresholds. Thirty-five patients undergoing spinal surgery for progressive cervical myelopathy were tracked from 2005 to 2015. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.12.013DOI Listing
January 2019
2 Reads

Fishing for Parkinson's Disease: A review of the literature.

J Clin Neurosci 2019 Jan 16. Epub 2019 Jan 16.

Department of Biochemistry, Faculty of Dentistry, Marmara University, Istanbul, Turkey. Electronic address:

Parkinson's disease (PD), the second most common neurodegenerative disorder in the world, is due to the damage or death of cells that produce dopamine in the region called the substantia nigra (SN). Model organisms are important tools in PD research. Zebrafish (Danio rerio), a small tropical freshwater fish, entered the scientific world through developmental biology studies and today has become a popular model organism for human diseases. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.015DOI Listing
January 2019

Spinal phosphaturic mesenchymal tumors: Case report and literature review.

J Clin Neurosci 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China. Electronic address:

Tumor-induced osteomalacia (TIO) is regarded as a rare paraneoplastic syndrome generally caused by phosphaturic mesenchymal tumors (PMTs). As far as we know, only 18 spinal PMTs have been described in the world's English literature. The purpose of this study is to increase familiarity with its clinical features, diagnosis, and treatment of spinal PMTs. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.010DOI Listing
January 2019
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Correlation between pre-admission blood pressure and outcome in a large telestroke cohort.

J Clin Neurosci 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA, United States. Electronic address:

Background: Telemedicine rapidly connects patients, with acute ischemic stroke symptoms, with neurovascular specialists for assessment to reduce chemical thrombolysis delivery times. Management of AIS includes maintaining target systolic blood pressures (SBP). In this retrospective study, we assess the efficacy of the telestroke (TS) system at a primary stroke center and the prognostic value of SBP throughout the transportation process. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.014DOI Listing
January 2019
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The effects of trans-cranial direct current stimulation intervention on fear: A systematic review of literature.

J Clin Neurosci 2019 Jan 16. Epub 2019 Jan 16.

Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.

Intensifying fear and fear of pain may lead to some diseases such as panic disorder, phobias, post-traumatic stress disorder (PTSD), anxiety disorders, depression, etc. A number of studies indicated positive effect of transcranial direct current stimulation (tDCS) on controlling fear and some studies did not observe any effect or even negative effect on decreasing fear. Due to lack of consensus in the findings of research, we aimed to systematically review studies, which investigated the effect of tDCS on fear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183210
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http://dx.doi.org/10.1016/j.jocn.2019.01.011DOI Listing
January 2019
5 Reads

Visualization of the supraorbital notch/foramen using magnetic resonance imaging.

J Clin Neurosci 2019 Jan 14. Epub 2019 Jan 14.

Department of Neurological Surgery, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan.

The supraorbital notch/foramen involving the segment of the supraorbital nerve (SON) and the supraorbital artery (SOA) has little been explored with magnetic resonance imaging (MRI). Therefore, we explored these structures using MRI. A total of 90 patients underwent thin-sliced contrast MRI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183055
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http://dx.doi.org/10.1016/j.jocn.2019.01.005DOI Listing
January 2019
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Fusion surgery with instrumentation following carbon ion radiotherapy for primary lumbar tumors: A case series.

J Clin Neurosci 2019 Jan 14. Epub 2019 Jan 14.

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Carbon-ion radiotherapy (CIRT) is a useful modality for treatment of primary spinal sarcoma, but osteonecrosis after CIRT may cause pseudoarthrosis that can make subsequent reconstruction surgery difficult. The patients were a 68-year-old man (case 1), a 30-year-old woman (case 2), and a 49-year-old man (case 3) with lumbar lesions. After CIRT, cases 1 and 3 were treated with instrumented spondylectomy and case 2 underwent posterior decompression and instrumentation surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183147
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http://dx.doi.org/10.1016/j.jocn.2019.01.001DOI Listing
January 2019
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Alterations of structural connectivity in episodic cluster headache: A graph theoretical analysis.

J Clin Neurosci 2019 Jan 14. Epub 2019 Jan 14.

Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea. Electronic address:

We evaluated structural volumes and connectivity using graph theoretical analysis in patients with cluster headache. Ten patients with episodic cluster headache were recruited, who had a normal brain MRI on visual inspection. We also enrolled a control group of 20 healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.007DOI Listing
January 2019
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Influence of comorbidities on treatment of unruptured intracranial aneurysms in the elderly.

J Clin Neurosci 2019 Jan 14. Epub 2019 Jan 14.

Department of Neurosurgery, Monash Health, Melbourne, Australia; Department of Surgery, Monash University, Melbourne, Australia. Electronic address:

Current evidence does not conclusively justify conservative management of unruptured intracranial aneurysms (UIA) in the elderly (age ≥ 65 years). To rationalise intervention, the authors investigated the role of age and comorbidity burden on treatment outcomes. A retrospective chart review for consecutive cases of UIAs treated in the elderly between 2007 and 2018 was performed. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.013DOI Listing
January 2019

Timing and prevalence of revision and removal surgeries after spinal cord stimulator implantation.

J Clin Neurosci 2019 Jan 14. Epub 2019 Jan 14.

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

We performed a retrospective study to characterize the timing and prevalence of revision and removal surgeries after spinal cord stimulator (SCS) implantation in patients with chronic pain. In our analysis of 100 patients who had SCS implants, we found that 34% of patients underwent revision surgery and 53% of patients had their implant removed. Of the patients who required revision surgeries, the majority (56%) eventually opted for removal of their SCS system. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.12.028DOI Listing
January 2019

A systematic review of interventions and outcomes in lung cancer metastases to the spine.

J Clin Neurosci 2019 Jan 14. Epub 2019 Jan 14.

Department of Neurological Surgery and the Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA.

Seventy percent of cancer patients will have metastatic bone disease, most commonly in the vertebra. Prognosis of metastatic lung cancer is poor and treatment is mostly palliative. To-date, there is no systematic review on the ideal treatment for lung cancer with spinal metastases in regards to mortality. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.006DOI Listing
January 2019

Bone bonding, displacement, and absorption in cases of double-door laminoplasty with unidirectional porous hydroxyapatite spacers.

J Clin Neurosci 2019 Jan 14. Epub 2019 Jan 14.

Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

We used a newly developed, high-porosity unidirectional porous hydroxyapatite spacer (Regenos spacer, not approved by the FDA). To assess the short-term bone bonding capacity of Regenos spacer used in a double-door laminoplasty, including displacement, deformation, and absorption after implantation. Fifty patients underwent a double-door laminoplasty using Regenos spacers, with computed tomography (CT) images obtained at 2-4 weeks and 6-12 months, post-surgery, in 30 patients. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.012DOI Listing
January 2019
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Fluid and energy intake in stroke patients during acute hospitalization in a stroke unit.

J Clin Neurosci 2019 Jan 14. Epub 2019 Jan 14.

Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, University of Trieste, Trieste, Italy.

Proper hydration and nutrition have been found to be contributing factors to a better recovery in patients after stroke. A better knowledge of factors influencing fluid and energy intake may contribute to a better care of the acute stroke patient. Aim of this study was to describe hydration status, fluid intake, and energy intake of stroke patients during acute hospitalization in a stroke unit. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.016DOI Listing
January 2019
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