1,399 results match your criteria Journal of Clinical Apheresis [Journal]


Therapeutic effect of double plasma molecular adsorption system and sequential half-dose plasma exchange in patients with HBV-related acute-on-chronic liver failure.

J Clin Apher 2019 Feb 13. Epub 2019 Feb 13.

Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.

Objective: The artificial liver support system (ALSS) is used frequently as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). This study aims to compare the therapeutic efficacy of double plasma molecular adsorption system (DPMAS) with sequential half-dose plasma exchange (PE) (DPMAS+PE) and full-dose PE in patients with HBV-ACLF.

Methods: A total of 131 hospitalized patients who were diagnosed with HBV-ACLF and underwent DPMAS+PE or PE were retrospectively analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21690DOI Listing
February 2019

HIV-associated thrombotic thrombocytopaenic purpura: A retrospective cohort study during the anti-retroviral therapy era.

J Clin Apher 2019 Feb 13. Epub 2019 Feb 13.

Division of General Medicine, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, Western Cape, South Africa.

Background: HIV-associated thrombotic thrombocytopaenic purpura (TTP) is thought to represent the majority of current TTP diagnoses in South Africa (SA).

Aim: The primary aim was to describe the clinical features and compare the time to remission of TTP in those patients with and without HIV.

Design: A retrospective cohort study conducted at Tygerberg Hospital in Cape Town, SA for the period January 1, 2010 to January 31, 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21692DOI Listing
February 2019
1.579 Impact Factor

Immunoadsorption or plasma exchange in steroid-refractory multiple sclerosis and neuromyelitis optica.

J Clin Apher 2019 Jan 30. Epub 2019 Jan 30.

Department of Nephrology and Rheumatology, Georg-August-University Göttingen, Germany.

Background: Plasma exchange (PE) and immunoadsorption (IA) are alternative treatments of steroid-refractory relapses of multiple sclerosis (MS) or neuromyelitis optica (NMO).

Methods: Adverse events and neurological follow-ups in 127 MS- (62 PE, 65 IA) and 13 NMO- (11 PE, 2 IA) patients were retrospectively analyzed. Response was defined by improvements in either expanded disability status scale (EDSS) by at least 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21686DOI Listing
January 2019

Factors predicting peripheral blood progenitor cell mobilization in healthy donors in the era of related alternative donors: Experience from a single center.

J Clin Apher 2019 Jan 29. Epub 2019 Jan 29.

Hematology and Hemotherapy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Poor mobilization results are unexpected after G-CSF-induced peripheral blood stem cell collection in healthy donors. However, 2%-5% of the donors are poor mobilizers. Factors predicting CD34+-cell yield after mobilization in related alternative donors are still poorly known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21685DOI Listing
January 2019

Solving the calcium gluconate shortage in real-time: Mistakes made and lessons learned.

J Clin Apher 2019 Jan 23. Epub 2019 Jan 23.

Division of Laboratory Medicine, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.

Purpose: During a national shortage of calcium gluconate, we switched to calcium chloride for routine supplementation for peripheral blood stem cell (PBSC) collections. Subsequently, we analyzed the postprocedure ionized calcium level, as we aimed for an equivalent result compared to before the shortage.

Methods: Pharmacy representatives helped us to find an "equivalent" substitute for calcium gluconate at 46. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21684DOI Listing
January 2019
5 Reads

Therapeutic thrombocytapheresis for extreme thrombocytosis after chemotherapy in essential thrombocytosis.

J Clin Apher 2019 Jan 9. Epub 2019 Jan 9.

Apheresis Unit, Department of Hemotherapy and Hemostasis, Hematology and Oncology Institute, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Essential thrombocytosis (ET) is a chronic myeloproliferative neoplasm characterized by the presence of thrombocytosis and it can be complicated by thrombotic and/or hemorrhagic events. Treatment options include low-dose aspirin and cytoreductive agents such as hydroxyurea. In cases of extreme thrombocytosis, therapeutic thrombocytapheresis can be a useful procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21683DOI Listing
January 2019
5 Reads

Discoloration of plasma associated with Atovaquone in therapeutic plasma exchange.

J Clin Apher 2018 Dec 30. Epub 2018 Dec 30.

Department of Pathology and Laboratory Medicine, Blood Bank, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21682DOI Listing
December 2018
1 Read

Impact of the hematocrit value of the blood prime unit on patient hematocrit values after therapeutic plasma exchange in children weighing 10 kg or less.

J Clin Apher 2018 Dec 28. Epub 2018 Dec 28.

Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin.

We report the impact of measuring the hematocrit (HCT) of blood prime units (BPUs) on postprocedure patient HCT values in a small child with transverse myelitis undergoing therapeutic plasma exchange (TPE). Initially, the BPU HCT values were not measured, according to our apheresis policy of using our blood center's estimated HCT value. This approach resulted in unexpected increasing elevations of our patient's post-TPE HCT after the first two TPE procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21681DOI Listing
December 2018

Efficacy of three consecutive therapeutic plasma exchanges in major ABO-incompatible hematopoietic stem cell transplantation.

J Clin Apher 2018 Dec 20. Epub 2018 Dec 20.

Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Introduction: We retrospectively analyzed data of recipients who underwent three consecutive therapeutic plasma exchanges (TPEs) before major ABO-incompatible (ABOi) hematopoietic stem cell transplantation (HSCT) in our hospital from 2012 to 2017 and evaluated the efficacy of TPE for successful ABOi HSCT.

Materials And Methods: We investigated the efficacy of TPE in 29 recipients with major ABOi HSCT based on the following: (1) requirement of red blood cell (RBC) transfusion during 100 days, (2) erythrocyte engraftment by reticulocyte count at 3 months, and (3) erythropoiesis recovery by bone marrow examination at 1 month and 3 months after ABOi HSCT.

Results: IgM and IgG donor-specific isoagglutinins (DSIs) of 31 cases of TPE were significantly decreased after three consecutive TPEs (IgM median, 1:32 to 1:2, P < . Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21680
Publisher Site
http://dx.doi.org/10.1002/jca.21680DOI Listing
December 2018
1 Read

Mononuclear cell collection for extracorporeal photopheresis by using the "off-line" system: A comparative study between COBE Spectra and Spectra Optia devices.

J Clin Apher 2018 Dec 14. Epub 2018 Dec 14.

Hemathology and Hemotherapy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Extracorporeal photopheresis (ECP) is an efficient and established therapy to treat acute and chronic graft vs host disease (GVHD). Using an "off-line" method, the first step (mononuclear cell [MNC] collection) is decisive, as long as a high MNC yield and purity in the collected product is desirable. Two "off-line" devices were compared: the COBE Spectra and the Spectra Optia (Terumo BCT), using both continuous and intermittent protocols. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jca.21679
Publisher Site
http://dx.doi.org/10.1002/jca.21679DOI Listing
December 2018
2 Reads

New subcutaneous PowerFlow port results in cost and time-savings in a busy outpatient apheresis clinic.

J Clin Apher 2018 Dec 12. Epub 2018 Dec 12.

Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama.

Many vascular access options, such as subcutaneous ports, are currently on the market for use in both medication infusion and for procedures, such as therapeutic plasma exchange and extracorporeal photopheresis. We compared the cost and time necessary to complete apheresis procedures using either Angiodynamic's Vortex or Bard's PowerFlow subcutaneous ports by reviewing our experience on two patients undergoing long-term apheresis treatments with at least 10 procedures with each type of port. We analyzed the cost of needles and thrombolytic therapy, staff time, overall procedure length, and the total time the patient was in the apheresis unit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21678DOI Listing
December 2018
1 Read

Literature review of apheresis procedures performed perioperatively in cardiac surgery for ASFA category indications.

J Clin Apher 2018 Dec 8. Epub 2018 Dec 8.

Department of Clinical Hematology - Blood Bank and Hemostasis, Onassis Cardiac Surgery Center, Kallithea, Greece.

Background: Perioperative therapeutic plasma exchange in patients with cardiovascular diseases poses several challenges, including alterations in intravascular volume, serum electrolytes, the coagulation cascade, and drug pharmacokinetics.

Methods: This review article summarizes different indications of plasma exchange for patients requiring cardiac surgery based on reported case reports and case series.

Results: The most common reported indication is plasma exchange for the management of allosensitized cardiac transplant candidate patients in combination with immunosuppressive regimens, which increases the likelihood of obtaining a cross-match-negative allograft, improving post-transplant clinical outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21676DOI Listing
December 2018
2 Reads

Treatment-resistant PLA2R-negative membranous nephropathy responsive to low-density lipoprotein apheresis.

J Clin Apher 2018 Dec 10. Epub 2018 Dec 10.

Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA.

Idiopathic membranous nephropathy is the most common cause of nephrotic syndrome in nondiabetic adults. The antibody most often implicated is the M-type phospholipase A2 receptor (PLA2R) antibody, found in >70% of primary membranous nephropathy cases. First-line therapy is immunosuppressive in nature, but for patients who are treatment-resistant there is a significant risk of end-stage renal disease and mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21677DOI Listing
December 2018
2 Reads

Thrombotic thrombocytopenic purpura: A 5-year tertiary care centre experience.

J Clin Apher 2019 Feb 8;34(1):44-50. Epub 2018 Dec 8.

Department of Molecular Medicine and Haematology, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: Thrombotic thrombocytopenic purpura (TTP) is associated with high mortality if not managed timeously with therapeutic plasma exchange (TPE). TTP secondary to human immunodeficiency virus (HIV) infection is unique to sub-Saharan Africa. The management and outcome of TTP in the era of improved access to therapy has not been described. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jca.21673
Publisher Site
http://dx.doi.org/10.1002/jca.21673DOI Listing
February 2019
3 Reads

Combined heparin/acid citrate dextrose solution A anticoagulation in the Optia continuous mononuclear cell protocol for pediatric lymphocyte apheresis.

J Clin Apher 2018 Nov 29. Epub 2018 Nov 29.

New York Blood Center, New York, New York.

Collecting a sufficient number of T-cells is a critical first step in the production of chimeric antigen receptor (CAR)-T cells. Herein, we report a successful implementation of anticoagulation with combined heparin and acid citrate dextrose solution A (ACD-A) for the continuous mononuclear cell (CMNC) protocol on the Spectra Optia in a 20-month-old, 7.5 kg patient with refractory acute lymphoblastic leukemia for manufacture of tisagenlecleucel, a CAR-T cell therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21675DOI Listing
November 2018
1.579 Impact Factor

Low titer A plasma in three AB patients for therapeutic plasma exchange.

J Clin Apher 2019 Feb 23;34(1):7-12. Epub 2018 Nov 23.

Institute for Transfusion Medicine, Pittsburgh, Pennsylvania.

Background: Currently, low titer A plasma is used on a routine basis in bleeding trauma patients of unknown AB type. Three AB non-bleeding apheresis patients are presented here who safely received a combination of AB and low titer A plasma during therapeutic plasma exchange (TPE). One control AB patient received AB plasma only. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21656DOI Listing
February 2019
26 Reads

The use of cytapheresis in the treatment of infectious diseases.

Authors:

J Clin Apher 2018 Dec;33(6):685-686

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21668DOI Listing
December 2018

Impact of good and poor mobilizers on hematopoietic progenitor cell collection efficiency and product quality.

J Clin Apher 2019 Feb 14;34(1):39-43. Epub 2018 Nov 14.

Division of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida.

Background: Mobilization regimen choice is a significant contributing factor for successful hematopoietic progenitor cell (HPC) collection by leukocytapheresis and reaching the target CD34+ cell dose. How mobilization regimen affects collection efficiency and the quality of products collected using the Spectra Optia apheresis instrument is not fully known.

Methods: We evaluated the impact of granulocyte-colony stimulating factor (GCSF) and GCSF/plerixafor mobilization regimens on CE and product composition. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21672
Publisher Site
http://dx.doi.org/10.1002/jca.21672DOI Listing
February 2019
8 Reads

A case review of a patient experience of photopheresis using a peripherally inserted central catheter.

J Clin Apher 2019 Feb 10;34(1):73-74. Epub 2018 Nov 10.

Photopheresis, Rotherham Foundation Trust, Rotherham, United Kingdom.

Extracorporeal photopheresis (ECP) is a cell based immunomodulatory therapy in which the patient is attached intravenously to a cell separating machine. During ECP a patient's blood is collected via either a central venous access device (CVAD) or a peripherally inserted 16G arterial venous fistula needle in either one or both antecubital fossa. However, patients presenting for ECP with GVHD repeatedly present a challenge to the ECP team due to poor venous access resulting from previous therapies and skin changes. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/journal/10981101
Web Search
https://onlinelibrary.wiley.com/toc/10981101/0/0
Web Search
http://doi.wiley.com/10.1002/jca.21674
Publisher Site
http://dx.doi.org/10.1002/jca.21674DOI Listing
February 2019
14 Reads

Granulomonocytapheresis as a cell-dependent treatment option for patients with inflammatory bowel disease: Concepts and clinical features for better therapeutic outcomes.

J Clin Apher 2019 Feb 8;34(1):51-60. Epub 2018 Nov 8.

Department of Gastroenterology, Pisa University Hospital, Pisa, Italy.

Ulcerative colitis (UC) and Crohn's disease (CD) are major phenotypes of the chronic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms. The chronic nature of IBD means that patients require life-long medications, and this may lead to drug dependency, loss of response together with adverse side effects as additional morbidity factors. The efficacy of antitumour necrosis factor (TNF)-α biologics has validated the role of inflammatory cytokines notably TNF-α in the exacerbation and perpetuation of IBD. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21670
Publisher Site
http://dx.doi.org/10.1002/jca.21670DOI Listing
February 2019
9 Reads

Influence of vascular access devices upon efficiency of therapeutic plasma exchange.

J Clin Apher 2019 Feb 8;34(1):33-38. Epub 2018 Nov 8.

Service de Réanimation Neurologique, Hospices civils de Lyon, Bron Cedex, France.

Background: An efficient vascular access is mandatory for the proper conduction of therapeutic plasma exchanges (TPE). Peripheral and central venous catheters may be used, with respective advantages and limitations. In this study, vascular access devices (IV catheter, dialysis cannula, central venous catheter) and anatomic vein characteristics were evaluated. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21669
Publisher Site
http://dx.doi.org/10.1002/jca.21669DOI Listing
February 2019
10 Reads

Plasma exchange for heparin-induced thrombocytopenia in patients on extracorporeal circuits: A challenging case and a survey of the field.

J Clin Apher 2019 Feb 8;34(1):64-72. Epub 2018 Nov 8.

Department of Pathology, The University of Chicago, Chicago, Illinois.

Current management of heparin-induced thrombocytopenia (HIT) involves prompt discontinuation of all heparin products and concomitant initiation of a direct thrombin or anti-Xa inhibitor for anticoagulation. In the setting of HIT complicated by an urgent need for cardiopulmonary bypass (CPB), the safety and the efficacy of short-term heparin-based anticoagulation after therapeutic plasma exchange (TPE) have been previously demonstrated. Patients with HIT requiring TPE are frequently on extracorporeal circuits (either CPB, extracorporeal membrane oxygenation [ECMO] or external ventricular assist devices [VADs]). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21671
Publisher Site
http://dx.doi.org/10.1002/jca.21671DOI Listing
February 2019
12 Reads

ADAMTS13 kinetics after therapeutic plasma exchange and plasma infusion in patients with Upshaw-Schulman syndrome.

J Clin Apher 2019 Feb 5;34(1):13-20. Epub 2018 Nov 5.

Blood Centre, University Hospital Ostrava, Ostrava, Czech Republic.

Background: Hereditary thrombotic thrombocytopenic purpura, also called Upshaw-Schulman syndrome (USS), is a rare disease caused by genetic mutations in the ADAMTS13 gene, which severely decrease the activity of ADAMTS13, a metalloprotease that cleaves von Willebrand factor multimers (VWF). Genotypically identical patients can show great phenotypic diversity.

Objectives: Comparison of selected laboratory parameters and ADAMTS13 pharmacokinetics among patients with USS was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21664DOI Listing
February 2019
3 Reads

Favorable impact of extracorporeal photopheresis in acute and chronic graft versus host disease: Prospective single-center study.

J Clin Apher 2018 Dec 5;33(6):654-660. Epub 2018 Nov 5.

Hematology Department and BMT Unit, George Papanicolaou Hospital, Thessaloniki, Greece.

Background: Graft vs host disease (GVHD) is the most severe complication of allogeneic hematopoietic cell transplantation. Conventional immunosuppressive therapy increases morbidity and mortality without improving survival. Extracorporeal photopheresis (ECP) has been introduced as an alternative treatment in steroid-dependent and steroid-refractory disease. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21660
Publisher Site
http://dx.doi.org/10.1002/jca.21660DOI Listing
December 2018
9 Reads
1.580 Impact Factor

Indwelling ports for prophylactic RBC exchanges in sickle cell patients: Comparison of bard and vortex ports.

J Clin Apher 2018 Dec 2;33(6):666-670. Epub 2018 Nov 2.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Introduction: Red blood cell exchange (RCE) procedures are commonly used for stroke prevention in sickle cell disease (SCD) patients. We compared two different dual lumen ports used for RCE because differences between the port and catheter design may lead to functional variance.

Methods: We reviewed the RCE parameters of SCD patients following implantable port placement encountered at a single institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21663DOI Listing
December 2018

Patient consultation about a trial of therapeutic plasma exchange for complex regional pain syndrome.

J Clin Apher 2018 Dec 2;33(6):661-665. Epub 2018 Nov 2.

Clinical Ethics, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom.

Background: Complex regional pain syndrome (CRPS) is a severe post-traumatic chronic pain condition affecting distal limbs, for which few effective treatments exist. Complex regional pain syndrome is listed in the 2016 American Society for Apheresis guidelines as an indication for plasma exchange treatment, but patient perspectives are lacking.

Study Design And Methods: We convened a "patient and public consultation exercise. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21662
Publisher Site
http://dx.doi.org/10.1002/jca.21662DOI Listing
December 2018
8 Reads

Single-needle: an effective alternative to dual-needle peripheral access in therapeutic plasma exchange.

J Clin Apher 2019 Feb 2;34(1):21-25. Epub 2018 Nov 2.

Division of Transfusion Medicine and Hemostasis, Department of Pathology, UT Southwestern Medical Center, Dallas, Texas.

Apheresis treatments, which involve the removal of a component of blood, generally require one access and one return line to continuously draw and return blood into the extracorporeal circuit. At our center, we prefer to use peripheral venous access to avoid central line-related complications, especially infection. Motivated by patient-centered care, the single-needle (SN) option for therapeutic plasma exchange (TPE) offered on the Spectra Optia (Terumo BCT, Lakewood, CO) was evaluated. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21665
Publisher Site
http://dx.doi.org/10.1002/jca.21665DOI Listing
February 2019
4 Reads

Red blood cell exchange in treatment of severe cerebral P. falciparum malaria: A case report.

J Clin Apher 2019 Feb 2;34(1):61-63. Epub 2018 Nov 2.

Division of Nephrology, Medical Director of Therapeutic Apheresis service, Loma Linda University Medical Center, Loma Linda, California.

Introduction: Red blood cells exchange transfusion has been demonstrated to be helpful in treatment of sever P. falciparum malaria. However, no large scale randomized controlled trials have been completed to date and the CDC does not recommend RBC exchange transfusions as standard of care. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21667
Publisher Site
http://dx.doi.org/10.1002/jca.21667DOI Listing
February 2019
5 Reads

Hemostasis testing and therapeutic plasma exchange: Results of a practice survey.

J Clin Apher 2019 Feb 30;34(1):26-32. Epub 2018 Oct 30.

Department of Coagulation, Quest Diagnostics Nichols Institute, Virginia.

Introduction: Performing therapeutic plasma exchange (TPE) with albumin replacement decreases coagulation factor and platelet levels. No defined guidelines exist regarding laboratory testing to assess hemostasis in patients undergoing TPE.

Materials And Methods: A survey to evaluate hemostasis testing with TPE was distributed using online survey software. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21666DOI Listing
February 2019
1 Read

Cost-minimization analysis in the Indian subcontinent for treating Guillain Barre Syndrome patients with therapeutic plasma exchange as compared to intravenous immunoglobulin.

J Clin Apher 2018 Dec 17;33(6):631-637. Epub 2018 Oct 17.

Department of Transfusion Medicine, PGIMER, Chandigarh, India.

Background: Therapeutic Plasma Exchange (TPE) and Intravenous Immunoglobulin both are first-line treatments for Guillain Barre Syndrome; however, there is a significant difference in cost. We undertook this study to assess the cost minimization for treating Guillain Barre Syndrome patients.

Methods: A prospective randomized controlled trial was undertaken, in which 40 Guillain Barre Syndrome (GBS) patients with a GBS disability score of grade four and five were enrolled. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21646
Publisher Site
http://dx.doi.org/10.1002/jca.21646DOI Listing
December 2018
9 Reads

Choosing Wisely for apheresis.

J Clin Apher 2018 Oct;33(5):576-579

University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington.

The Choosing Wisely campaign has stimulated clinicians to think about the appropriateness of various tests and procedures, compelling physicians to make smarter, safer and more effective choices for high quality patient care and to reduce healthcare cost. The American Society for Apheresis (ASFA) strives to advance apheresis medicine through education, evidence-based practice, research and advocacy. To complement these shared missions, ASFA created a working group, consisting of representatives from the various ASFA committees, to produce recommendations for apheresis medicine that reflect the Choosing Wisely guiding principles. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21643
Publisher Site
http://dx.doi.org/10.1002/jca.21643DOI Listing
October 2018
10 Reads

Therapeutic white blood cell and platelet depletions using the spectra OPTIA system continuous mononuclear cell protocol.

J Clin Apher 2018 Oct;33(5):580-585

Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.

The Spectra Optia apheresis system has only recently been approved by the Food and Drug Administration (FDA) for therapeutic white blood cell (WBC) depletions and is not yet approved for platelet depletions. Prior to FDA-approval of the WBC depletion protocol, when our available COBE Spectra apheresis systems were out of service, we successfully performed WBC depletion using a modified Spectra Optia apheresis system Continuous Mononuclear Cell (CMNC) protocol. Using this modified Spectra Optia CMNC protocol, we created institutional protocols for WBC and platelet depletions. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21644
Publisher Site
http://dx.doi.org/10.1002/jca.21644DOI Listing
October 2018
9 Reads

Weathering the storm: A case of thyroid storm refractory to conventional treatment benefiting from therapeutic plasma exchange.

J Clin Apher 2018 Dec 15;33(6):678-681. Epub 2018 Oct 15.

Department of Pathology, Division of Transfusion Medicine, University of Texas Medical Branch, Galveston, Texas.

Thyroid storm is a severe manifestation of thyrotoxicosis characterized by systemic organ dysfunction secondary to a hypermetabolic state. Although antithyroid drugs, steroids, beta-blockers, antipyretics, and cholestyramine are the standard of care, some patients inadequately respond to these conventional therapies. Therapeutic plasma exchange has been previously utilized as a treatment modality in patients with a poor response to routine therapies or with contraindications to them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21658DOI Listing
December 2018
1 Read

Efficacy of therapeutic plasma exchange on angiotensin II type-1 receptor antibodies on two kidney transplant recipients.

J Clin Apher 2018 Dec 15;33(6):673-677. Epub 2018 Oct 15.

Division of Transfusion Medicine, Department of Pathology, University of Michigan, Ann Arbor, Michigan.

Background: Angiotensin II type-1 receptor antibody (AT1RAb) has been reported to cause antibody mediated rejection (AMR) in kidney transplant recipients possibly by contraction of renal arteries. We here report 2 kidney transplant recipients with elevated AT1RAbs and negative HLA donor specific antibodies (DSA) and anti-major histocompatibility complex class I chain-related gene A (MICA) Abs who received therapeutic plasma exchange (TPE) treatment followed by IVIG. CASE 1: Thirty-eight-year-old patient received second kidney transplant for end stage renal disease (ESRD) with chronic rejection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21657DOI Listing
December 2018

Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action.

J Clin Apher 2018 Dec 15;33(6):638-644. Epub 2018 Oct 15.

Department of Women and Children's Health, King's College London, London, United Kingdom.

Introduction: Intrahepatic cholestasis of pregnancy is characterised by pruritus and elevated serum bile acids. The pruritus can be severe, and pharmacological options achieve inconsistent symptomatic improvement. Raised bile acids are linearly associated with adverse fetal outcomes, with existing management of limited benefit. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21654
Publisher Site
http://dx.doi.org/10.1002/jca.21654DOI Listing
December 2018
3 Reads

Clinical presentation in thrombotic thrombocytopenic purpura: Real-world data from two Mexican institutions.

J Clin Apher 2018 Dec 15;33(6):645-653. Epub 2018 Oct 15.

Hematology Service, Department of Internal Medicine, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Background: Thrombotic thrombocytopenic purpura (TTP) is a hematologic disease that can be fatal if not treated early. We aimed to describe the clinical characteristics of Mexican patients with idiopathic TTP.

Study Design And Methods: We conducted a retrospective study, including all adult patients diagnosed with idiopathic TTP from 2011 to 2017 in two Mexican centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21659DOI Listing
December 2018
6 Reads

Reducing allogeneic blood exposure in low blood volume extracorporeal photopheresis patients through use of a modified blood prime.

J Clin Apher 2018 Dec 15;33(6):682-684. Epub 2018 Oct 15.

Department of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, Arizona.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21661DOI Listing
December 2018

Changes in serum afamin and vitamin E levels after selective LDL apheresis.

J Clin Apher 2018 Oct 3;33(5):569-575. Epub 2018 Sep 3.

Department of Internal Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary.

Background: Afamin is a plasma vitamin E-binding glycoprotein partially associated with ApoA1-containing high-density lipoprotein (HDL) subfractions. In a previous study, the serum vitamin E decreased after low-density lipoprotein (LDL) apheresis, while vitamin E/cholesterol ratio increased. We aimed to study the effect of LDL apheresis on serum afamin level. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jca.21636
Publisher Site
http://dx.doi.org/10.1002/jca.21636DOI Listing
October 2018
12 Reads

Visualization of bacterial contamination in an apheresis platelet unit.

J Clin Apher 2018 Dec 22;33(6):671-672. Epub 2018 Sep 22.

Department of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21649DOI Listing
December 2018
16 Reads

Hemostasis management and therapeutic plasma exchange: Results of a practice survey.

J Clin Apher 2018 Oct 12;33(5):604-610. Epub 2018 Sep 12.

Bloodworks, Seattle, Western Australia.

Background: Patients undergoing therapeutic plasma exchange (TPE) may present with risks for hemorrhage or thrombosis. Use of replacement fluids devoid of coagulation factors will decrease factor levels and platelet levels. There are no established guidelines for hemostasis management in these situations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21653DOI Listing
October 2018
9 Reads

Prediction of immunoglobulin M reduction via therapeutic dose of simple plasma exchange and double filtration plasmapheresis using membrane separation in patients with hyperviscosity syndrome caused by Waldenstrom macroglobulinemia.

J Clin Apher 2018 Oct 6;33(5):611-615. Epub 2018 Sep 6.

Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, Tokyo, Japan.

Background: Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target molecule immunoglobulin M (IgM), especially in the modality using membrane separation.

Objectives: This study was conducted to establish a model to predict the IgM reduction rate by the dose of simple PE and DFPP using membrane separation in patients with HVS and to compare the consumption of albumin between PE and DFPP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21655DOI Listing
October 2018
14 Reads

The impact of motivational interviewing on self-perceived burden in patients receiving therapeutic plasma exchange.

J Clin Apher 2018 Oct 3;33(5):586-590. Epub 2018 Sep 3.

Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Autoimmune disorders and neurodegenerative disorders take a physical and emotional toll on patients that undergo therapeutic plasma exchange (TPE) treatments. Previous literature has shown that these patients may feel a greater sense of self-burden. Motivational Interviewing (MI) is a technique used in various settings that has the potential to decrease feelings of self-burden. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21645DOI Listing
October 2018
1 Read

Debunking superstition: Analyzing the cloud phenomenon in apheresis-Results of a 35-month study.

J Clin Apher 2018 Oct 3;33(5):616-618. Epub 2018 Sep 3.

Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California.

Many practitioners believe in the phenomenon of being labeled either a "black cloud" or "white cloud" while on-call. A "white-cloud" physician is usually defined as one who sees fewer cases while a "black-cloud" is one who often receives more cases. To evaluate these phenomena, a 35-month prospective study was designed to evaluate the number of times apheresis staff was involved with emergent apheresis procedures at a large institution in the off hours between 10 pm and 7 am, since this is the time period when significant resources have to be mobilized to perform the procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21650DOI Listing
October 2018

Indication-specific immunomodulatory effects of extracorporeal photopheresis: A pilot study in heart transplanted patients.

J Clin Apher 2018 Oct 3;33(5):591-599. Epub 2018 Sep 3.

Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany.

Background: The clinical use of extracorporeal photopheresis (ECP) is based on its ability to induce cell-mediated immune tolerance towards foreign and self-antigens. Up-to-date, no clear consensus consists on how to use ECP after heart transplantation (HTx). In this pilot study, we evaluated the stimulatory effects of ECP on immune cells in HTx patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21647DOI Listing
October 2018

Prophylactic infusion of calcium gluconate to prevent a symptomatic fall in plasma ionized calcium during therapeutic plasma exchange: A comparison of two methods.

J Clin Apher 2018 Oct 11;33(5):600-603. Epub 2018 Aug 11.

Transfusion Medicine and Apheresis Service, UMass Memorial Medical Center, Worcester, Massachusetts.

We compared two methods of calcium gluconate infusion to maintain plasma ionized calcium ([Ca ]) during therapeutic plasma exchange (TPE) performed using the Spectra Optia Apheresis System. Method A, our legacy method, consisted of adding 5 mL of 10% calcium gluconate to each 500 mL bottle of 5% albumin replacement fluid. Method B used an accessory IV infusion of calcium gluconate (2 g in 50 mL of 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21648DOI Listing
October 2018
7 Reads

Depletion of αβ T cells for a haploidentical hematopoietic stem cell transplantation in children.

J Clin Apher 2018 Aug 3;33(4):521-528. Epub 2018 Jul 3.

College of Nursing, The Catholic University of Korea, Seoul, Korea.

A consistent and reproducible depletion technique is crucial for the successful transplantation of an ex vivo depleted graft. Our aim was to evaluate the efficacy of an ex vivo technique for depletion of αβ T cells using a biotinylated anti-TCRαβ monoclonal antibody, which was performed by one clinical nurse specialist. Between 2012 and 2017, 119 depletion procedures from 216 apheresis using the anti-TCRαβ monoclonal antibody were performed on 105 pediatric patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21634DOI Listing
August 2018
1 Read

The definition of severe systemic lupus erythematosus needs clarification in the next ASFA guidelines.

J Clin Apher 2018 Aug 3;33(4):551-552. Epub 2018 Jul 3.

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21635DOI Listing
August 2018
5 Reads

Extracorporeal photopheresis and personalized medicine in the 21st century: The future's so bright!

J Clin Apher 2018 Aug 7;33(4):461-463. Epub 2018 May 7.

Department of Pathology and Laboratory Medicine, Department of Veterans Affairs, White River Junction, Vermont.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jca.21633DOI Listing
August 2018
30 Reads