1,416 results match your criteria Journal of Clinical Apheresis [Journal]


Adverse events during apheresis: A 10-year experience at a tertiary academic medical center.

J Clin Apher 2019 Apr 5. Epub 2019 Apr 5.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Background: Apheresis can be associated with adverse events (AEs). Available studies published on apheresis-associated AEs lack uniformity of data. Unfortunately, there is no common database in the United States (US) to report apheresis-associated AEs. Read More

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http://dx.doi.org/10.1002/jca.21706DOI Listing
April 2019
1.579 Impact Factor

Efficacy of three filgrastim-intended copies for hematopoietic stem cell mobilization in healthy adult and pediatric donors in Mexico.

J Clin Apher 2019 Apr 4. Epub 2019 Apr 4.

Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Hematology Department, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Introduction: The use of filgrastim biosimilars for healthy adult and pediatric donor mobilization in hematopoietic stem cell transplantation has been met with increased safety and efficacy concerns in contrast to generic small molecule drugs. In Mexico, several filgrastim-intended copies (FIC) have been available and marketed since 2001, while no clinical comparability studies to evaluate their use in this setting have been published and thus are not considered to be true biosimilars. In this study, we report our experience using three different FIC products currently available (Filatil, Dextrifyl, and Biofilgran). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jca.21707
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http://dx.doi.org/10.1002/jca.21707DOI Listing
April 2019
6 Reads

Risk of hypotensive reactions is increased when using partial saline replacement for therapeutic plasma exchange.

J Clin Apher 2019 Mar 19. Epub 2019 Mar 19.

Medical Sciences Institute, BloodCenter of Wisconsin, part of Versiti, Milwaukee, Wisconsin.

Background: Partial normal saline replacement during plasma exchange procedures is a common practice to reduce procedure costs but may increase the risk of adverse events, such as hypotension and citrate reactions. The goal of this study was to compare adverse event rates for the patients that used albumin or albumin/saline as replacement.

Study Design And Methods: A retrospective chart review was done of plasma exchange procedures that used all albumin or 80% albumin to 20% normal saline (80/20) as replacement. Read More

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http://dx.doi.org/10.1002/jca.21703DOI Listing

Implantable ports for therapeutic apheresis: A cautionary tale.

J Clin Apher 2019 Mar 13. Epub 2019 Mar 13.

Therapeutic Services, Vitalant, Las Vegas, Nevada.

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http://dx.doi.org/10.1002/jca.21702DOI Listing

In vitro PUVA treatment triggers calreticulin exposition and HMGB1 release by dying T lymphocytes in GVHD: New insights in extracorporeal photopheresis.

J Clin Apher 2019 Mar 12. Epub 2019 Mar 12.

Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Grenoble, France.

Background: Extracorporeal photopheresis (ECP) is an effective therapy for graft vs host disease (GVHD), based on infusion of UVA-irradiated and 8 methoxy-psoralen (PUVA)-treated leukocytes. Reinfusion of these apoptosing cells affects the functionality of pathogenic T cells through poorly understood immunomodulatory mechanisms. Apoptosis is usually a silent, tolerance-associated process, but can also be immunogenic, depending on death-inducers and environmental context. Read More

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http://doi.wiley.com/10.1002/jca.21698
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http://dx.doi.org/10.1002/jca.21698DOI Listing
March 2019
4 Reads

The establishment of in-house neurology driven therapeutic plasma exchange infrastructure in a resource-limited public hospital in Malaysia: Adopting and integrating evidenced-based health care technology through time.

J Clin Apher 2019 Mar 4. Epub 2019 Mar 4.

Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.

There has been an increase in the use of therapeutic plasma exchange (TPE) in immune-mediated neurological disorders in recent years. However, accessibility and availability of TPE remains low and costly, especially for a country with limited healthcare funding like Malaysia. With expanding clinical indications in neurological disorders, and increasingly expensive conventional immunomodulatory treatment such as intravenous immunoglobulin and monoclonal antibodies, TPE remains an effective part of first or second-line treatment. Read More

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http://doi.wiley.com/10.1002/jca.21696
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http://dx.doi.org/10.1002/jca.21696DOI Listing
March 2019
15 Reads

Performance prediction algorithm for autologous PBSC collection in adults and pediatric patients using large volume leukapheresis.

J Clin Apher 2019 Mar 4. Epub 2019 Mar 4.

Department of Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb, Croatia.

Background And Objectives: The number of CD34+ cells collected in apheresis procedures depends mainly on the collection efficiency of the device and the blood volume processed. Large volume leukapheresis (LVL) can improve CD34+ cell yield and has previously been investigated using the COBE Spectra device (Terumo BCT, USA).

Materials And Methods: This was a retrospective analysis of LVL performance in patients undergoing continuous mononuclear cell collection (CMNC) using the new Spectra Optia apheresis system (Terumo BCT, USA) at the University Hospital Center, Zagreb, from March 2016 to September 2016. Read More

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http://dx.doi.org/10.1002/jca.21693DOI Listing
March 2019
9 Reads

An automated mini buffy coat preparation method for use in mini extracorporeal photopheresis treatment of graft-vs-host-disease in a low body weight pediatric patient.

J Clin Apher 2019 Mar 4. Epub 2019 Mar 4.

Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia.

A mini extracorporeal photopheresis (mini-ECP) "off line" technique has been developed for use in the treatment of small children and patients with apheresis contraindications. Until now various methods have been used for buffy coat separation from whole blood. In this report we describe a protocol for mini buffy coat preparation using the automated Sepax laboratory separator for "off line" ECP treatment in a low body weight child with graft-vs-host-disease. Read More

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http://doi.wiley.com/10.1002/jca.21700
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http://dx.doi.org/10.1002/jca.21700DOI Listing
March 2019
7 Reads

Tissue plasminogen activator vs heparin for locking central venous catheters between apheresis procedures.

J Clin Apher 2019 Mar 4. Epub 2019 Mar 4.

Department of Pathology, University of Iowa, Iowa City, Iowa.

Background: Central venous catheters (CVCs) for apheresis procedures require regular locking/flushes to maintain adequate flow rates. Literature comparing locking solutions for apheresis, where the time interval between procedures can be longer than for hemodialysis (many days to weeks), is lacking. In this study, catheter malfunction rates using recombinant tissue plasminogen activator (rt-PA) vs heparin for locking CVC between apheresis procedures were compared. Read More

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http://doi.wiley.com/10.1002/jca.21697
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http://dx.doi.org/10.1002/jca.21697DOI Listing
March 2019
5 Reads

Comparison and cost analysis of three protocols for mobilization and apheresis of haematopoietic progenitor cells.

J Clin Apher 2019 Feb 28. Epub 2019 Feb 28.

Department of Hematology, Hospital General Universitario de Alicante (institution where the work was performed), Alicante, Spain.

Introduction: Autologous bone marrow transplantation is a component of the malignant hemopathy therapy. The preferred mobilization and collection method is apheresis. The aim of this study is to compare three protocols analyzing the effect of plerixafor, higher dose of G-CSF and large volume leukapheresis (LVL). Read More

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http://dx.doi.org/10.1002/jca.21699DOI Listing
February 2019
1.579 Impact Factor

Real-world study: Escalating targeted lipid-lowering treatment with PCSK9-inhibitors and lipoprotein apheresis.

J Clin Apher 2019 Feb 28. Epub 2019 Feb 28.

Apheresis Research Institute, Cologne, Germany.

Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition with monoclonal antibodies has complemented the armamentarium of lipid-lowering therapy (LLT) before the final step of commencing chronic lipoprotein apheresis (LA). Data are scarce on patients who, after escalation of LLT with PCSK9 antibodies, have commenced chronic LA or PCSK9 antibody treatment during ongoing long-term LA.

Patients And Methods: In this study, a cohort of 110 patients with established atherosclerotic cardiovascular disease (ASCVD) due to hypercholesterolemia or concomitant lipoprotein(a)-hyperlipoproteinemia, who received PCSK9 antibodies for the first time during routine care, were consecutively identified. Read More

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http://dx.doi.org/10.1002/jca.21695DOI Listing
February 2019
3 Reads

Excellent response to therapeutic plasma exchange in myasthenia gravis patients irrespective of antibody status.

J Clin Apher 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

Introduction: The primary objective of this study was to assess response to plasma exchange (PLEX) in myasthenia gravis (MG) patients with and without autoantibodies (Ab) to acetylcholine receptor (AChR) or muscle-specific kinase (MuSK). Analysis was also done to determine if correlation existed between sex, early or late onset MG, thymoma, or thymectomy and response to PLEX.

Materials And Methods: Data was analyzed on 58 consecutive MG patients treated with PLEX. Read More

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http://dx.doi.org/10.1002/jca.21694DOI Listing
February 2019
2 Reads

Role of therapeutic plasma exchange in snake bite associated thrombotic microangiopathy-A case report with review of literature.

J Clin Apher 2019 Feb 19. Epub 2019 Feb 19.

Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Post snake bite renal failure due to thrombotic microangiopathy (TMA) is often overlooked and not considered as a separate entity while managing the patient. This case report highlights the efficacy of Therapeutic Plasma Exchange in managing the post envenomation TMA. Anti-snake venom was administered following severe hematotoxic envenomation, but later on developed acute kidney injury and hence hemodialysis was done for 2 days without much improvement. Read More

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http://dx.doi.org/10.1002/jca.21691DOI Listing
February 2019
1 Read

Neutropenic fever and stem cell mobilization.

J Clin Apher 2019 Feb 19. Epub 2019 Feb 19.

Faculty of Medicine, Department of Hematology, Stem Cell Transplantation Unit, Ankara University, Ankara, Turkey.

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http://doi.wiley.com/10.1002/jca.21688
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http://dx.doi.org/10.1002/jca.21688DOI Listing
February 2019
2 Reads

A case off TTP temporally associated with cocaine use: Implications for treatment of suspected DITMA.

J Clin Apher 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, West Virginia University Hospital, Morgantown, West Virginia.

Thrombotic microangiopathies are rare diseases associated with significant morbidity and mortality. The treatment of thrombotic thrombocytopenic purpura (TTP) and drug-induced thrombotic microangiopathy (DITMA) remains a diagnostic dilemma as they present similarly but respond differently to standard treatment with plasma exchange. TTP is a deficiency of a disintegrin and metalloprotease with thrombospondin type 1 motif 13 resulting in von Willebrand factor aggregates. Read More

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http://doi.wiley.com/10.1002/jca.21687
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http://dx.doi.org/10.1002/jca.21687DOI Listing
February 2019
6 Reads

A proposal for sectorial organizing and quality standards in therapeutic apheresis: The therapeutic apheresis unit (TAU) standards.

J Clin Apher 2019 Feb 18. Epub 2019 Feb 18.

Transfusion Medicine and Stem Cell Unit, San Camillo Forlanini Hospital, Rome, Italy.

Therapeutic apheresis (TA) includes a wide range of therapeutic procedures based on the separation of blood components and the collection of cells with therapeutic activity or the removal of unwanted plasma or cellular components involved in the etiology of various hematologic, renal, neurological, and medical diseases. The complexity of these interventions requires an organizing model to assure a proper clinical environment, technology, quality requirements, and personnel as well as an active system for outcome monitoring for safety and efficacy. Finally, a structured organizing model may favor the efficiency of the TA unit and economic affordability. Read More

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http://dx.doi.org/10.1002/jca.21689DOI Listing
February 2019

Therapeutic effect of double plasma molecular adsorption system and sequential half-dose plasma exchange in patients with HBV-related acute-on-chronic liver failure.

J Clin Apher 2019 Feb 13. Epub 2019 Feb 13.

Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.

Objective: The artificial liver support system (ALSS) is used frequently as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). This study aims to compare the therapeutic efficacy of double plasma molecular adsorption system (DPMAS) with sequential half-dose plasma exchange (PE) (DPMAS+PE) and full-dose PE in patients with HBV-ACLF.

Methods: A total of 131 hospitalized patients who were diagnosed with HBV-ACLF and underwent DPMAS+PE or PE were retrospectively analyzed. Read More

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http://dx.doi.org/10.1002/jca.21690DOI Listing
February 2019
4 Reads

HIV-associated thrombotic thrombocytopaenic purpura: A retrospective cohort study during the anti-retroviral therapy era.

J Clin Apher 2019 Feb 13. Epub 2019 Feb 13.

Division of General Medicine, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, Western Cape, South Africa.

Background: HIV-associated thrombotic thrombocytopaenic purpura (TTP) is thought to represent the majority of current TTP diagnoses in South Africa (SA).

Aim: The primary aim was to describe the clinical features and compare the time to remission of TTP in those patients with and without HIV.

Design: A retrospective cohort study conducted at Tygerberg Hospital in Cape Town, SA for the period January 1, 2010 to January 31, 2015. Read More

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http://dx.doi.org/10.1002/jca.21692DOI Listing
February 2019
4 Reads
1.579 Impact Factor

Immunoadsorption or plasma exchange in steroid-refractory multiple sclerosis and neuromyelitis optica.

J Clin Apher 2019 Jan 30. Epub 2019 Jan 30.

Department of Nephrology and Rheumatology, Georg-August-University Göttingen, Germany.

Background: Plasma exchange (PE) and immunoadsorption (IA) are alternative treatments of steroid-refractory relapses of multiple sclerosis (MS) or neuromyelitis optica (NMO).

Methods: Adverse events and neurological follow-ups in 127 MS- (62 PE, 65 IA) and 13 NMO- (11 PE, 2 IA) patients were retrospectively analyzed. Response was defined by improvements in either expanded disability status scale (EDSS) by at least 1. Read More

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http://dx.doi.org/10.1002/jca.21686DOI Listing
January 2019

Factors predicting peripheral blood progenitor cell mobilization in healthy donors in the era of related alternative donors: Experience from a single center.

J Clin Apher 2019 Jan 29. Epub 2019 Jan 29.

Hematology and Hemotherapy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Poor mobilization results are unexpected after G-CSF-induced peripheral blood stem cell collection in healthy donors. However, 2%-5% of the donors are poor mobilizers. Factors predicting CD34+-cell yield after mobilization in related alternative donors are still poorly known. Read More

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http://dx.doi.org/10.1002/jca.21685DOI Listing
January 2019
1 Read

Solving the calcium gluconate shortage in real-time: Mistakes made and lessons learned.

J Clin Apher 2019 Jan 23. Epub 2019 Jan 23.

Division of Laboratory Medicine, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.

Purpose: During a national shortage of calcium gluconate, we switched to calcium chloride for routine supplementation for peripheral blood stem cell (PBSC) collections. Subsequently, we analyzed the postprocedure ionized calcium level, as we aimed for an equivalent result compared to before the shortage.

Methods: Pharmacy representatives helped us to find an "equivalent" substitute for calcium gluconate at 46. Read More

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http://dx.doi.org/10.1002/jca.21684DOI Listing
January 2019
6 Reads

Therapeutic thrombocytapheresis for extreme thrombocytosis after chemotherapy in essential thrombocytosis.

J Clin Apher 2019 Jan 9. Epub 2019 Jan 9.

Apheresis Unit, Department of Hemotherapy and Hemostasis, Hematology and Oncology Institute, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Essential thrombocytosis (ET) is a chronic myeloproliferative neoplasm characterized by the presence of thrombocytosis and it can be complicated by thrombotic and/or hemorrhagic events. Treatment options include low-dose aspirin and cytoreductive agents such as hydroxyurea. In cases of extreme thrombocytosis, therapeutic thrombocytapheresis can be a useful procedure. Read More

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http://dx.doi.org/10.1002/jca.21683DOI Listing
January 2019
15 Reads

Discoloration of plasma associated with Atovaquone in therapeutic plasma exchange.

J Clin Apher 2018 Dec 30. Epub 2018 Dec 30.

Department of Pathology and Laboratory Medicine, Blood Bank, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/jca.21682DOI Listing
December 2018
3 Reads

Impact of the hematocrit value of the blood prime unit on patient hematocrit values after therapeutic plasma exchange in children weighing 10 kg or less.

J Clin Apher 2018 Dec 28. Epub 2018 Dec 28.

Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin.

We report the impact of measuring the hematocrit (HCT) of blood prime units (BPUs) on postprocedure patient HCT values in a small child with transverse myelitis undergoing therapeutic plasma exchange (TPE). Initially, the BPU HCT values were not measured, according to our apheresis policy of using our blood center's estimated HCT value. This approach resulted in unexpected increasing elevations of our patient's post-TPE HCT after the first two TPE procedures. Read More

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http://dx.doi.org/10.1002/jca.21681DOI Listing
December 2018
1 Read

Efficacy of three consecutive therapeutic plasma exchanges in major ABO-incompatible hematopoietic stem cell transplantation.

J Clin Apher 2018 Dec 20. Epub 2018 Dec 20.

Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Introduction: We retrospectively analyzed data of recipients who underwent three consecutive therapeutic plasma exchanges (TPEs) before major ABO-incompatible (ABOi) hematopoietic stem cell transplantation (HSCT) in our hospital from 2012 to 2017 and evaluated the efficacy of TPE for successful ABOi HSCT.

Materials And Methods: We investigated the efficacy of TPE in 29 recipients with major ABOi HSCT based on the following: (1) requirement of red blood cell (RBC) transfusion during 100 days, (2) erythrocyte engraftment by reticulocyte count at 3 months, and (3) erythropoiesis recovery by bone marrow examination at 1 month and 3 months after ABOi HSCT.

Results: IgM and IgG donor-specific isoagglutinins (DSIs) of 31 cases of TPE were significantly decreased after three consecutive TPEs (IgM median, 1:32 to 1:2, P < . Read More

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http://doi.wiley.com/10.1002/jca.21680
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http://dx.doi.org/10.1002/jca.21680DOI Listing
December 2018
2 Reads

Mononuclear cell collection for extracorporeal photopheresis by using the "off-line" system: A comparative study between COBE Spectra and Spectra Optia devices.

J Clin Apher 2018 Dec 14. Epub 2018 Dec 14.

Hemathology and Hemotherapy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Extracorporeal photopheresis (ECP) is an efficient and established therapy to treat acute and chronic graft vs host disease (GVHD). Using an "off-line" method, the first step (mononuclear cell [MNC] collection) is decisive, as long as a high MNC yield and purity in the collected product is desirable. Two "off-line" devices were compared: the COBE Spectra and the Spectra Optia (Terumo BCT), using both continuous and intermittent protocols. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jca.21679
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http://dx.doi.org/10.1002/jca.21679DOI Listing
December 2018
5 Reads

New subcutaneous PowerFlow port results in cost and time-savings in a busy outpatient apheresis clinic.

J Clin Apher 2018 Dec 12. Epub 2018 Dec 12.

Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama.

Many vascular access options, such as subcutaneous ports, are currently on the market for use in both medication infusion and for procedures, such as therapeutic plasma exchange and extracorporeal photopheresis. We compared the cost and time necessary to complete apheresis procedures using either Angiodynamic's Vortex or Bard's PowerFlow subcutaneous ports by reviewing our experience on two patients undergoing long-term apheresis treatments with at least 10 procedures with each type of port. We analyzed the cost of needles and thrombolytic therapy, staff time, overall procedure length, and the total time the patient was in the apheresis unit. Read More

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http://dx.doi.org/10.1002/jca.21678DOI Listing
December 2018
4 Reads

Literature review of apheresis procedures performed perioperatively in cardiac surgery for ASFA category indications.

J Clin Apher 2018 Dec 8. Epub 2018 Dec 8.

Department of Clinical Hematology - Blood Bank and Hemostasis, Onassis Cardiac Surgery Center, Kallithea, Greece.

Background: Perioperative therapeutic plasma exchange in patients with cardiovascular diseases poses several challenges, including alterations in intravascular volume, serum electrolytes, the coagulation cascade, and drug pharmacokinetics.

Methods: This review article summarizes different indications of plasma exchange for patients requiring cardiac surgery based on reported case reports and case series.

Results: The most common reported indication is plasma exchange for the management of allosensitized cardiac transplant candidate patients in combination with immunosuppressive regimens, which increases the likelihood of obtaining a cross-match-negative allograft, improving post-transplant clinical outcome. Read More

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http://dx.doi.org/10.1002/jca.21676DOI Listing
December 2018
5 Reads

Treatment-resistant PLA2R-negative membranous nephropathy responsive to low-density lipoprotein apheresis.

J Clin Apher 2018 Dec 10. Epub 2018 Dec 10.

Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA.

Idiopathic membranous nephropathy is the most common cause of nephrotic syndrome in nondiabetic adults. The antibody most often implicated is the M-type phospholipase A2 receptor (PLA2R) antibody, found in >70% of primary membranous nephropathy cases. First-line therapy is immunosuppressive in nature, but for patients who are treatment-resistant there is a significant risk of end-stage renal disease and mortality. Read More

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http://dx.doi.org/10.1002/jca.21677DOI Listing
December 2018
3 Reads

Thrombotic thrombocytopenic purpura: A 5-year tertiary care centre experience.

J Clin Apher 2019 Feb 8;34(1):44-50. Epub 2018 Dec 8.

Department of Molecular Medicine and Haematology, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: Thrombotic thrombocytopenic purpura (TTP) is associated with high mortality if not managed timeously with therapeutic plasma exchange (TPE). TTP secondary to human immunodeficiency virus (HIV) infection is unique to sub-Saharan Africa. The management and outcome of TTP in the era of improved access to therapy has not been described. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jca.21673
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http://dx.doi.org/10.1002/jca.21673DOI Listing
February 2019
5 Reads

Combined heparin/acid citrate dextrose solution A anticoagulation in the Optia continuous mononuclear cell protocol for pediatric lymphocyte apheresis.

J Clin Apher 2018 Nov 29. Epub 2018 Nov 29.

New York Blood Center, New York, New York.

Collecting a sufficient number of T-cells is a critical first step in the production of chimeric antigen receptor (CAR)-T cells. Herein, we report a successful implementation of anticoagulation with combined heparin and acid citrate dextrose solution A (ACD-A) for the continuous mononuclear cell (CMNC) protocol on the Spectra Optia in a 20-month-old, 7.5 kg patient with refractory acute lymphoblastic leukemia for manufacture of tisagenlecleucel, a CAR-T cell therapy. Read More

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http://dx.doi.org/10.1002/jca.21675DOI Listing
November 2018
2 Reads
1.579 Impact Factor

Low titer A plasma in three AB patients for therapeutic plasma exchange.

J Clin Apher 2019 Feb 23;34(1):7-12. Epub 2018 Nov 23.

Institute for Transfusion Medicine, Pittsburgh, Pennsylvania.

Background: Currently, low titer A plasma is used on a routine basis in bleeding trauma patients of unknown AB type. Three AB non-bleeding apheresis patients are presented here who safely received a combination of AB and low titer A plasma during therapeutic plasma exchange (TPE). One control AB patient received AB plasma only. Read More

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http://dx.doi.org/10.1002/jca.21656DOI Listing
February 2019
30 Reads

The use of cytapheresis in the treatment of infectious diseases.

Authors:

J Clin Apher 2018 Dec;33(6):685-686

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http://dx.doi.org/10.1002/jca.21668DOI Listing
December 2018
1 Read

Impact of good and poor mobilizers on hematopoietic progenitor cell collection efficiency and product quality.

J Clin Apher 2019 Feb 14;34(1):39-43. Epub 2018 Nov 14.

Division of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida.

Background: Mobilization regimen choice is a significant contributing factor for successful hematopoietic progenitor cell (HPC) collection by leukocytapheresis and reaching the target CD34+ cell dose. How mobilization regimen affects collection efficiency and the quality of products collected using the Spectra Optia apheresis instrument is not fully known.

Methods: We evaluated the impact of granulocyte-colony stimulating factor (GCSF) and GCSF/plerixafor mobilization regimens on CE and product composition. Read More

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http://doi.wiley.com/10.1002/jca.21672
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http://dx.doi.org/10.1002/jca.21672DOI Listing
February 2019
12 Reads

A case review of a patient experience of photopheresis using a peripherally inserted central catheter.

J Clin Apher 2019 Feb 10;34(1):73-74. Epub 2018 Nov 10.

Photopheresis, Rotherham Foundation Trust, Rotherham, United Kingdom.

Extracorporeal photopheresis (ECP) is a cell based immunomodulatory therapy in which the patient is attached intravenously to a cell separating machine. During ECP a patient's blood is collected via either a central venous access device (CVAD) or a peripherally inserted 16G arterial venous fistula needle in either one or both antecubital fossa. However, patients presenting for ECP with GVHD repeatedly present a challenge to the ECP team due to poor venous access resulting from previous therapies and skin changes. Read More

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https://onlinelibrary.wiley.com/journal/10981101
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https://onlinelibrary.wiley.com/toc/10981101/0/0
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http://doi.wiley.com/10.1002/jca.21674
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http://dx.doi.org/10.1002/jca.21674DOI Listing
February 2019
22 Reads

Granulomonocytapheresis as a cell-dependent treatment option for patients with inflammatory bowel disease: Concepts and clinical features for better therapeutic outcomes.

J Clin Apher 2019 Feb 8;34(1):51-60. Epub 2018 Nov 8.

Department of Gastroenterology, Pisa University Hospital, Pisa, Italy.

Ulcerative colitis (UC) and Crohn's disease (CD) are major phenotypes of the chronic inflammatory bowel disease (IBD), which afflicts millions of individuals throughout the world with debilitating symptoms. The chronic nature of IBD means that patients require life-long medications, and this may lead to drug dependency, loss of response together with adverse side effects as additional morbidity factors. The efficacy of antitumour necrosis factor (TNF)-α biologics has validated the role of inflammatory cytokines notably TNF-α in the exacerbation and perpetuation of IBD. Read More

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http://doi.wiley.com/10.1002/jca.21670
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http://dx.doi.org/10.1002/jca.21670DOI Listing
February 2019
15 Reads

Influence of vascular access devices upon efficiency of therapeutic plasma exchange.

J Clin Apher 2019 Feb 8;34(1):33-38. Epub 2018 Nov 8.

Service de Réanimation Neurologique, Hospices civils de Lyon, Bron Cedex, France.

Background: An efficient vascular access is mandatory for the proper conduction of therapeutic plasma exchanges (TPE). Peripheral and central venous catheters may be used, with respective advantages and limitations. In this study, vascular access devices (IV catheter, dialysis cannula, central venous catheter) and anatomic vein characteristics were evaluated. Read More

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http://doi.wiley.com/10.1002/jca.21669
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http://dx.doi.org/10.1002/jca.21669DOI Listing
February 2019
14 Reads

Plasma exchange for heparin-induced thrombocytopenia in patients on extracorporeal circuits: A challenging case and a survey of the field.

J Clin Apher 2019 Feb 8;34(1):64-72. Epub 2018 Nov 8.

Department of Pathology, The University of Chicago, Chicago, Illinois.

Current management of heparin-induced thrombocytopenia (HIT) involves prompt discontinuation of all heparin products and concomitant initiation of a direct thrombin or anti-Xa inhibitor for anticoagulation. In the setting of HIT complicated by an urgent need for cardiopulmonary bypass (CPB), the safety and the efficacy of short-term heparin-based anticoagulation after therapeutic plasma exchange (TPE) have been previously demonstrated. Patients with HIT requiring TPE are frequently on extracorporeal circuits (either CPB, extracorporeal membrane oxygenation [ECMO] or external ventricular assist devices [VADs]). Read More

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http://doi.wiley.com/10.1002/jca.21671
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http://dx.doi.org/10.1002/jca.21671DOI Listing
February 2019
20 Reads

ADAMTS13 kinetics after therapeutic plasma exchange and plasma infusion in patients with Upshaw-Schulman syndrome.

J Clin Apher 2019 Feb 5;34(1):13-20. Epub 2018 Nov 5.

Blood Centre, University Hospital Ostrava, Ostrava, Czech Republic.

Background: Hereditary thrombotic thrombocytopenic purpura, also called Upshaw-Schulman syndrome (USS), is a rare disease caused by genetic mutations in the ADAMTS13 gene, which severely decrease the activity of ADAMTS13, a metalloprotease that cleaves von Willebrand factor multimers (VWF). Genotypically identical patients can show great phenotypic diversity.

Objectives: Comparison of selected laboratory parameters and ADAMTS13 pharmacokinetics among patients with USS was performed. Read More

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http://dx.doi.org/10.1002/jca.21664DOI Listing
February 2019
5 Reads

Favorable impact of extracorporeal photopheresis in acute and chronic graft versus host disease: Prospective single-center study.

J Clin Apher 2018 Dec 5;33(6):654-660. Epub 2018 Nov 5.

Hematology Department and BMT Unit, George Papanicolaou Hospital, Thessaloniki, Greece.

Background: Graft vs host disease (GVHD) is the most severe complication of allogeneic hematopoietic cell transplantation. Conventional immunosuppressive therapy increases morbidity and mortality without improving survival. Extracorporeal photopheresis (ECP) has been introduced as an alternative treatment in steroid-dependent and steroid-refractory disease. Read More

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http://doi.wiley.com/10.1002/jca.21660
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http://dx.doi.org/10.1002/jca.21660DOI Listing
December 2018
12 Reads
1.580 Impact Factor

Indwelling ports for prophylactic RBC exchanges in sickle cell patients: Comparison of bard and vortex ports.

J Clin Apher 2018 Dec 2;33(6):666-670. Epub 2018 Nov 2.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Introduction: Red blood cell exchange (RCE) procedures are commonly used for stroke prevention in sickle cell disease (SCD) patients. We compared two different dual lumen ports used for RCE because differences between the port and catheter design may lead to functional variance.

Methods: We reviewed the RCE parameters of SCD patients following implantable port placement encountered at a single institution. Read More

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http://dx.doi.org/10.1002/jca.21663DOI Listing
December 2018
1 Read

Patient consultation about a trial of therapeutic plasma exchange for complex regional pain syndrome.

J Clin Apher 2018 Dec 2;33(6):661-665. Epub 2018 Nov 2.

Clinical Ethics, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom.

Background: Complex regional pain syndrome (CRPS) is a severe post-traumatic chronic pain condition affecting distal limbs, for which few effective treatments exist. Complex regional pain syndrome is listed in the 2016 American Society for Apheresis guidelines as an indication for plasma exchange treatment, but patient perspectives are lacking.

Study Design And Methods: We convened a "patient and public consultation exercise. Read More

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http://doi.wiley.com/10.1002/jca.21662
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http://dx.doi.org/10.1002/jca.21662DOI Listing
December 2018
10 Reads

Single-needle: an effective alternative to dual-needle peripheral access in therapeutic plasma exchange.

J Clin Apher 2019 Feb 2;34(1):21-25. Epub 2018 Nov 2.

Division of Transfusion Medicine and Hemostasis, Department of Pathology, UT Southwestern Medical Center, Dallas, Texas.

Apheresis treatments, which involve the removal of a component of blood, generally require one access and one return line to continuously draw and return blood into the extracorporeal circuit. At our center, we prefer to use peripheral venous access to avoid central line-related complications, especially infection. Motivated by patient-centered care, the single-needle (SN) option for therapeutic plasma exchange (TPE) offered on the Spectra Optia (Terumo BCT, Lakewood, CO) was evaluated. Read More

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http://doi.wiley.com/10.1002/jca.21665
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http://dx.doi.org/10.1002/jca.21665DOI Listing
February 2019
6 Reads

Red blood cell exchange in treatment of severe cerebral P. falciparum malaria: A case report.

J Clin Apher 2019 Feb 2;34(1):61-63. Epub 2018 Nov 2.

Division of Nephrology, Medical Director of Therapeutic Apheresis service, Loma Linda University Medical Center, Loma Linda, California.

Introduction: Red blood cells exchange transfusion has been demonstrated to be helpful in treatment of sever P. falciparum malaria. However, no large scale randomized controlled trials have been completed to date and the CDC does not recommend RBC exchange transfusions as standard of care. Read More

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http://doi.wiley.com/10.1002/jca.21667
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http://dx.doi.org/10.1002/jca.21667DOI Listing
February 2019
6 Reads

Hemostasis testing and therapeutic plasma exchange: Results of a practice survey.

J Clin Apher 2019 Feb 30;34(1):26-32. Epub 2018 Oct 30.

Department of Coagulation, Quest Diagnostics Nichols Institute, Virginia.

Introduction: Performing therapeutic plasma exchange (TPE) with albumin replacement decreases coagulation factor and platelet levels. No defined guidelines exist regarding laboratory testing to assess hemostasis in patients undergoing TPE.

Materials And Methods: A survey to evaluate hemostasis testing with TPE was distributed using online survey software. Read More

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http://dx.doi.org/10.1002/jca.21666DOI Listing
February 2019
7 Reads

Cost-minimization analysis in the Indian subcontinent for treating Guillain Barre Syndrome patients with therapeutic plasma exchange as compared to intravenous immunoglobulin.

J Clin Apher 2018 Dec 17;33(6):631-637. Epub 2018 Oct 17.

Department of Transfusion Medicine, PGIMER, Chandigarh, India.

Background: Therapeutic Plasma Exchange (TPE) and Intravenous Immunoglobulin both are first-line treatments for Guillain Barre Syndrome; however, there is a significant difference in cost. We undertook this study to assess the cost minimization for treating Guillain Barre Syndrome patients.

Methods: A prospective randomized controlled trial was undertaken, in which 40 Guillain Barre Syndrome (GBS) patients with a GBS disability score of grade four and five were enrolled. Read More

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http://doi.wiley.com/10.1002/jca.21646
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http://dx.doi.org/10.1002/jca.21646DOI Listing
December 2018
10 Reads

Choosing Wisely for apheresis.

J Clin Apher 2018 Oct;33(5):576-579

University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington.

The Choosing Wisely campaign has stimulated clinicians to think about the appropriateness of various tests and procedures, compelling physicians to make smarter, safer and more effective choices for high quality patient care and to reduce healthcare cost. The American Society for Apheresis (ASFA) strives to advance apheresis medicine through education, evidence-based practice, research and advocacy. To complement these shared missions, ASFA created a working group, consisting of representatives from the various ASFA committees, to produce recommendations for apheresis medicine that reflect the Choosing Wisely guiding principles. Read More

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http://doi.wiley.com/10.1002/jca.21643
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http://dx.doi.org/10.1002/jca.21643DOI Listing
October 2018
17 Reads

Therapeutic white blood cell and platelet depletions using the spectra OPTIA system continuous mononuclear cell protocol.

J Clin Apher 2018 Oct;33(5):580-585

Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.

The Spectra Optia apheresis system has only recently been approved by the Food and Drug Administration (FDA) for therapeutic white blood cell (WBC) depletions and is not yet approved for platelet depletions. Prior to FDA-approval of the WBC depletion protocol, when our available COBE Spectra apheresis systems were out of service, we successfully performed WBC depletion using a modified Spectra Optia apheresis system Continuous Mononuclear Cell (CMNC) protocol. Using this modified Spectra Optia CMNC protocol, we created institutional protocols for WBC and platelet depletions. Read More

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http://doi.wiley.com/10.1002/jca.21644
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http://dx.doi.org/10.1002/jca.21644DOI Listing
October 2018
10 Reads

Weathering the storm: A case of thyroid storm refractory to conventional treatment benefiting from therapeutic plasma exchange.

J Clin Apher 2018 Dec 15;33(6):678-681. Epub 2018 Oct 15.

Department of Pathology, Division of Transfusion Medicine, University of Texas Medical Branch, Galveston, Texas.

Thyroid storm is a severe manifestation of thyrotoxicosis characterized by systemic organ dysfunction secondary to a hypermetabolic state. Although antithyroid drugs, steroids, beta-blockers, antipyretics, and cholestyramine are the standard of care, some patients inadequately respond to these conventional therapies. Therapeutic plasma exchange has been previously utilized as a treatment modality in patients with a poor response to routine therapies or with contraindications to them. Read More

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http://dx.doi.org/10.1002/jca.21658DOI Listing
December 2018
4 Reads