144 results match your criteria Journal of Circadian Rhythms [Journal]


Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation - a Systematic Review, Network Meta-analysis, and New Primary Data.

J Circadian Rhythms 2019 Jan 14;17. Epub 2019 Jan 14.

Institute for Laboratory Animal Science, Hannover Medical School, Hannover, DE.

Disruption of the monoaminergic system, e.g. by sleep deprivation (SD), seems to promote certain diseases. Read More

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http://dx.doi.org/10.5334/jcr.174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337052PMC
January 2019

A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms.

J Circadian Rhythms 2018 Oct 9;16:12. Epub 2018 Oct 9.

Janssen Research and Development, A Division of Janssen Pharmaceutica NV, BE.

Background: Microdialysis can be used to measure amino acids in the extracellular space in vivo, based on the principle of diffusion. Variations in experimental set-up result in variations in baseline levels of the compounds measured. Variations may also be due to circadian rhythms. Read More

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https://www.jcircadianrhythms.com/article/10.5334/jcr.172/
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http://dx.doi.org/10.5334/jcr.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196574PMC
October 2018
14 Reads

Intracerebral Adenosine During Sleep Deprivation: A Meta-Analysis and New Experimental Data.

J Circadian Rhythms 2018 Oct 9;16:11. Epub 2018 Oct 9.

The Netherlands Brain Institute, NL.

The neuroregulator adenosine is involved in sleep-wake control. Basal forebrain (BF) adenosine levels increase during sleep deprivation. Only a few studies have addressed the effect of sleep deprivation on extracellular adenosine concentrations in other brain regions. Read More

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http://dx.doi.org/10.5334/jcr.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196573PMC
October 2018
14 Reads

Overexpression of Prokineticin 2 in Transgenic Mice Leads to Reduced Circadian Behavioral Rhythmicity and Altered Molecular Rhythms in the Suprachiasmatic Clock.

J Circadian Rhythms 2018 Nov 6;16:13. Epub 2018 Nov 6.

Department of Pharmacology, University of California, Irvine, CA 92697, US.

In mammals, the master pacemaker driving circadian rhythms is thought to reside in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus. A clear view of molecular clock mechanisms within the SCN neurons has been elucidated. In contrast, much less is known about the output mechanism by which the SCN circadian pacemaker sends timing information for eventual control of physiological and behavioral rhythms. Read More

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http://www.jcircadianrhythms.com/articles/10.5334/jcr.170/
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http://dx.doi.org/10.5334/jcr.170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234414PMC
November 2018
17 Reads

Using the Analytic Network Process Method for Prioritizing and Weighing Shift Work Disorders Among the Personnel of Hospitals of Kerman University of Medical Sciences.

J Circadian Rhythms 2018 Oct 4;16:10. Epub 2018 Oct 4.

Department of Occupational Health, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR.

Introduction: Increasing population, the need for services, and industrialization of societies have led to a growing demand for shift work. Shiftwork causes several disorders, and determining the weight of each disorders is important for their prevention and treatment. Therefore, the purpose of the present study was to use Analytic Network Process (ANP) to prioritize and weigh shift work disorders among the personnel of hospitals of Kerman University of Medical Sciences. Read More

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http://dx.doi.org/10.5334/jcr.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183324PMC
October 2018
1 Read

Non-Image Forming Effects of Light on Brainwaves, Autonomic Nervous Activity, Fatigue, and Performance.

J Circadian Rhythms 2018 Sep 12;16. Epub 2018 Sep 12.

Department of Medical Physics and Biomedical Engineering and Research Center for Biomedical Technologies and Robotics (RCBTR), Tehran University of Medical Sciences, IR.

Fatigue and sleepiness are one of the main causes of human errors and accidents in the workplace. The empirical evidence has approved that, in addition to stimulating the visual system, light elicits brain responses, which affect physiological and neurobehavioral human functions, known as the non-image forming (NIF) effects of light. As recent evidences have shown the positive effects of red or low correlated color temperature white light on alertness and performance, we investigated whether exposure to 2564 K light could improve subjective and objective measures of alertness and performance compared with 7343 K, 3730 K, and dim light (DL) conditions during the daytime. Read More

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http://dx.doi.org/10.5334/jcr.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137608PMC
September 2018
1 Read

Circadian Effects on Performance and Effort in Collegiate Swimmers.

J Circadian Rhythms 2018 Aug 3;16. Epub 2018 Aug 3.

Department of Biology, Colgate University, NY, US.

Although individual athletic performance generally tends to peak in the evening, individuals who exhibit a strong diurnal preference perform better closer to their circadian peak. Time-of-day performance effects are influenced by circadian phenotype (diurnal preference and chronotype-sleep-wake patterns), homeostatic energy reserves and, potentially, genotype, yet little is known about how these factors influence physiological effort. Here, we investigate the effects of time of day, diurnal preference, chronotype, and (a circadian clock gene) genotype on both effort and performance in a population of Division I collegiate swimmers (n = 27). Read More

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http://www.jcircadianrhythms.com/articles/10.5334/jcr.165/
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http://dx.doi.org/10.5334/jcr.165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083775PMC
August 2018
7 Reads

Circadian Rhythms, Exercise, and Cardiovascular Health.

J Circadian Rhythms 2018 Jul 12;16. Epub 2018 Jul 12.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, US.

Human circadian rhythmicity is driven by a circadian clock comprised of two distinct components: the central clock, located in the suprachiasmatic nucleus (SCN) within the hypothalamus, and the peripheral clocks, located in almost all tissues and organ systems in the body. Entrainment, or alignment, of circadian rhythmicity is dependent upon time of day and can occur through environmental influences such as light cues and physical activity exerted on skeletal muscle. Entrainment of the circadian clock through exercise has been reported to improve health by reducing risk of conditions such as cardiovascular disease (CVD), but further research is still needed. Read More

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http://dx.doi.org/10.5334/jcr.164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083774PMC
July 2018
1 Read

P19 Cells as a Model for Studying the Circadian Clock in Stem Cells before and after Cell Differentiation.

J Circadian Rhythms 2018 May 18;16. Epub 2018 May 18.

Medical Core Facility and Research Platforms, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh 11426, SA.

In mammals, circadian rhythmicity is sustained via a transcriptional/translational feedback loop referred to as the canonical molecular circadian clock. Circadian rhythm is absent in undifferentiated embryonic stem cells; it begins only after differentiation. We used pluripotent P19 embryonal carcinoma stem cells to check the biological clock before and after differentiation into neurons using retinoic acid. Read More

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http://dx.doi.org/10.5334/jcr.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083773PMC
May 2018
6 Reads

Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats.

J Circadian Rhythms 2018 May 10;16. Epub 2018 May 10.

Faculty of Pharmaceutical Sciences, Josai International Universit, 1 Gumyo, Togane, Chiba 283-8555, JP.

The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar-Hannover rats were administered imipramine acutely or chronically in the morning or in the evening. Read More

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http://dx.doi.org/10.5334/jcr.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083812PMC
May 2018
1 Read

Are Type 2 Diabetes Mellitus and Depression Part of a Common Clock Genes Network?

J Circadian Rhythms 2018 Apr 18;16. Epub 2018 Apr 18.

Somnogen Canada Inc, College Street, Toronto, ON, CA.

In recent years, there has been an increased prevalence of type 2 diabetes mellitus (T2DM) and depression across the world. This growing public health problem has produced an increasing socioeconomic burden to the populations of all affected countries. Despite an awareness by public health officials and medical researchers of the costs associated with these diseases, there still remain many aspects of how they develop that are not understood. Read More

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http://dx.doi.org/10.5334/jcr.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083772PMC
April 2018
5 Reads

Relationship Between the Cortisol-Estradiol Phase Difference and Affect in Women.

J Circadian Rhythms 2018 Feb 21;16. Epub 2018 Feb 21.

Grand Valley State University, US.

Affective disorders impact women's health, with a lifetime prevalence of over twelve per cent. They have been correlated with reproductive cycle factors, under the regulation of hormonal circadian rhythms. In affective disorders, circadian rhythms may become desynchronized. Read More

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http://dx.doi.org/10.5334/jcr.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853846PMC
February 2018
8 Reads

Seasonal Variation in Bright Daylight Exposure, Mood and Behavior among a Group of Office Workers in Sweden.

J Circadian Rhythms 2018 Feb 21;16. Epub 2018 Feb 21.

Fukuoka Women's University, JP.

The purpose of the study was to investigate seasonal variation in mood and behavior among a group of office workers in Sweden (56°N). Thirty subjects participated in this longitudinal study. The subjects kept a weekly log that included questionnaires for ratings of psychological wellbeing and daily sleep-activity diaries where they also noted time spent outdoors. Read More

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http://dx.doi.org/10.5334/jcr.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853818PMC
February 2018
1 Read

Comparison of Melatonin Profile and Alertness of Firefighters with Different Work Schedules.

J Circadian Rhythms 2018 Feb 21;16. Epub 2018 Feb 21.

Department of Occupational Health, School of Health, Urmia University of Medical Sciences, Urmia, IR.

Introduction: A two-shift work schedule with different rotations is common among firefighters in Iranian petrochemical companies. This study compared salivary melatonin and sleepiness on the last night before turning to day shift at 19:00, 23:00, 3:00, and 7:00 among petrochemical firefighters (PFFs) working seven and four consecutive night shifts.

Methods: Sixty four PFFs working in the petrochemical industry were selected. Read More

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http://dx.doi.org/10.5334/jcr.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853812PMC
February 2018
1 Read

DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP.

J Circadian Rhythms 2017 Aug 11;15. Epub 2017 Aug 11.

Department of Medicine, Clinicum, University of Helsinki and Helsinki University Hospital, Helsinki, FI.

The expression of clock genes and are disturbed in rheumatoid arthritis, an autoimmune disease with circadian variation of symptoms. We have shown that TNF is a potent inducer of these genes. We investigated the regulation of and by TNF and elucidated their effect on other clock gene expressions. Read More

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http://dx.doi.org/10.5334/jcr.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624067PMC
August 2017
3 Reads

Daily Rhythms of Blood Parameters in Broiler Chickens Reared under Tropical Climate Conditions.

J Circadian Rhythms 2017 Aug 10;15. Epub 2017 Aug 10.

Department of Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, NG.

Several studies carried out on humans and other mammals show that the temporal organisation of haematological parameters in the blood exhibit daily rhythms; however, such studies have been rare in poultry reared under a natural photoperiod. The present study investigated the occurrence of daily rhythms in blood parameters of broiler chickens kept under tropical climatic conditions. Ten 6-7-week-old broiler chickens served as subjects of the study. Read More

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http://dx.doi.org/10.5334/jcr.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624059PMC
August 2017
1 Read

Neurophysiological Processing of an Emotional Task is Sensitive to Time-of-Day.

J Circadian Rhythms 2017 May 23;15. Epub 2017 May 23.

Department of Psychology and Neuroscience, Nova Southeastern University, Ft. Lauderdale, Florida, US.

Previous work from our laboratory has shown that a measure of attention to emotionally-charged stimuli, the late positive potential (LPP) event related potential (ERP), distinguished neutral from emotional pictures on a baseline day, but not after sleep deprivation. Here we sought to extend these findings and address the uncertainty about the effect of time-of-day on emotion processing by testing a morning group (8:00-10:00 a.m. Read More

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http://dx.doi.org/10.5334/jcr.148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624058PMC
May 2017
1 Read

Differential Expression of Circadian Genes in Leukemia and a Possible Role for Sirt1 in Restoring the Circadian Clock in Chronic Myeloid Leukemia.

J Circadian Rhythms 2017 Apr 28;15. Epub 2017 Apr 28.

Drug Discovery Unit-Core Facility Medical Platforms and Technology, King Abdullah International Medical Research Centre (KAIMRC), National Guard Health Affairs, Riyadh, SA.

Disregulation of genes making up the mammalian circadian clock has been associated with different forms of cancer. This study aimed to address how the circadian clock genes behave over the course of treatment for both the acute and chronic forms of leukemia and whether any could be used as potential biomarkers as a read-out for therapeutic efficacy. Expression profiling for both core and ancillary clock genes revealed that the majority of clock genes are down-regulated in acute myeloid leukemia patients, except for Cry2, which is up-regulated towards the end of treatment. Read More

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http://dx.doi.org/10.5334/jcr.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624060PMC
April 2017
1 Read

A Bibliometric Analysis of the Top 100 Most Cited Chronotype Research Papers.

Authors:
Ray Norbury

J Circadian Rhythms 2017 Jan 27;15. Epub 2017 Jan 27.

University of Roehampton, Psychology Department, Whitelands College, London, SW15 4JD, GB.

Bibliometric indices are a widely used measure of research impact. The aim of the current study was to identify and characterise the top one hundred most-cited research articles in the topic of chronotype research. A search of the Thomson Reuters Web of Science database returned 974 eligible articles (published between 1990 and 2016). Read More

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http://dx.doi.org/10.5334/jcr.146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356203PMC
January 2017
1 Read

Differences in Photic Entrainment of Circadian Locomotor Activity Between Lean and Obese Volcano Mice ().

J Circadian Rhythms 2017 Jan 27;15. Epub 2017 Jan 27.

Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, Qro, MX.

Obesity is a growing problem worldwide with a clear impact on health status. It is also a condition that negatively affects circadian rhythms. When the mouse is fed a regular rodent chow, some individuals develop obesity, representing an opportunity to compare the effects of spontaneous obesity upon the circadian organization in this species with that observed in other rodents with induced obesity. Read More

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http://dx.doi.org/10.5334/jcr.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356206PMC
January 2017
1 Read

Effects of Cold-Dry (Harmattan) and Hot-Dry Seasons on Daily Rhythms of Rectal and Body Surface Temperatures in Sheep and Goats in a Natural Tropical Environment.

J Circadian Rhythms 2016 Nov 29;14. Epub 2016 Nov 29.

Department of Veterinary Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.

Studies on daily rhythmicity in livestock under natural conditions are limited, and there is mounting evidence that rhythm patterns differ between chronobiological studies conducted in the laboratory and studies conducted under pronounced natural seasonality. Here, we investigated the influence of cold-dry (harmattan) and hot-dry seasons on daily rhythmicity of rectal (RT) and body surface temperatures (BST) in indigenous sheep and goats under natural light-dark cycles. The RT and BST of the animals, and the ambient temperature (AT) and relative humidity (RH) inside the pen, were measured every three hours for a period of two days, twice on separate days during the hot-dry and the harmattan seasons, respectively. Read More

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http://dx.doi.org/10.5334/jcr.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356205PMC
November 2016
1 Read

Circadian and Geotactic Behaviors: Genetic Pleiotropy in .

Authors:
Dale L Clayton

J Circadian Rhythms 2016 Jun 24;14. Epub 2016 Jun 24.

Department of Biology, La Sierra University, 4500 Riverwalk Parkway, Riverside, CA.

Data presented in this paper test the hypotheses that Hirsch's positive geotaxis and negative geotaxis strains of Drosophila melanogaster (fruit fly) differ in length of the free-running circadian activity period (tau) as well as adult geotaxis. Several genes have been shown to alter geotaxis in . Two of these genes, cryptochrome and Pigment-dispersing-factor are integral to the function of biological clocks. Read More

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http://dx.doi.org/10.5334/jcr.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356207PMC
June 2016
1 Read

A PER3 Polymorphism Interacts with Sleep Duration to Influence Transient Mood States in Women.

J Circadian Rhythms 2016 Mar 10;14. Epub 2016 Mar 10.

Department of Psychology and Neuroscience, Nova Southeastern University, Ft. Lauderdale, FL USA.

Background: Expression of the clock family of genes in the suprachiasmatic nuclei (SCN) regulates the molecular control of circadian timing. Increasing evidence also implicates clock gene activity in the development of mood disorders. In particular, variation in the PER3 clock gene has been shown to influence diurnal preference and sleep homeostasis. Read More

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http://dx.doi.org/10.5334/jcr.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834748PMC
March 2016
3 Reads

Circadian Phase-Shifting Effects of Bright Light, Exercise, and Bright Light + Exercise.

J Circadian Rhythms 2016 Feb 26;14. Epub 2016 Feb 26.

Department of Exercise Science, University of South Carolina, Columbia, SC, US.

Limited research has compared the circadian phase-shifting effects of bright light and exercise and additive effects of these stimuli. The aim of this study was to compare the phase-delaying effects of late night bright light, late night exercise, and late evening bright light followed by early morning exercise. In a within-subjects, counterbalanced design, 6 young adults completed each of three 2. Read More

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http://dx.doi.org/10.5334/jcr.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834751PMC
February 2016
8 Reads

Effects of Shift Work on Cognitive Performance, Sleep Quality, and Sleepiness among Petrochemical Control Room Operators.

J Circadian Rhythms 2016 Feb 3;14. Epub 2016 Feb 3.

Department of Psychology, Buali Sina University, Hamadan, Iran.

Shift work is associated with both sleepiness and reduced performance. The aim of this study was to examine cognitive performance, sleepiness, and sleep quality among petrochemical control room shift workers. Sixty shift workers participated in this study. Read More

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http://www.jcircadianrhythms.com/articles/10.5334/jcr.134/
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http://dx.doi.org/10.5334/jcr.134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834749PMC
February 2016
13 Reads

Opening the Debate: How to Fulfill the Need for Physicians' Training in Circadian-Related Topics in a Full Medical School Curriculum.

J Circadian Rhythms 2015 Nov 5;13. Epub 2015 Nov 5.

Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Integrated Cellular Responses Laboratory, Department of Biological Sciences, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia.

Background: Circadian rhythms are daily changes in our physiology and behavior that are manifested as patterns of brain wave activity, periodic hormone production, recurring cell regeneration, and other oscillatory biological activities. Their importance to human health is becoming apparent; they are deranged by shift work and jet-lag and in disparate conditions such as insomnia, sleep syndromes, coronary heart attacks, and depression, and are endogenous factors that contribute to cancer development and progression.

Discussion: As evidence of the circadian connection to human health has grown, so has the number of Americans experiencing disruption of circadian rhythms due to the demands of an industrialized society. Read More

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http://dx.doi.org/10.5334/jcr.ahDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835682PMC
November 2015
8 Reads

Sleep and Food Choice in a Dutch Student Population.

J Circadian Rhythms 2015 Jul 13;13. Epub 2015 Jul 13.

Dept. of Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience (NIN), an institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA, Amsterdam, the Netherlands; Dept. of Endocrinology and Metabolism, Academic Medical Center (AMC), University of Amsterdam (UvA), Meibergdreef 9, 1105AZ, Amsterdam, the Netherlands.

Background: The increased risk of obesity among short sleepers is most likely explained by increased energy intake. However, food intake could not only be altered quantitavely but also qualitatively. Therefore, we performed a correlational analysis on self-reported food intake and sleep in 51 students from Maastricht and surroundings. Read More

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http://dx.doi.org/10.5334/jcr.agDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831296PMC
July 2015
4 Reads

Intermittent Food Absence Motivates Reallocation of Locomotion and Feeding in Spotted Munia (Lonchura punctulata).

J Circadian Rhythms 2015 Jun 8;13. Epub 2015 Jun 8.

DST IRHPA Center for Excellence in Biological Rhythm Research, Department of Zoology, University of Lucknow, India.

Background: Daily feeding and locomotion are interrelated behaviours. The time spent in feeding and rate of food intake depends on food availability. In low food condition, the birds would show intense movement (locomotion) for a longer time throughout the day however during abundant food supply they may chose higher activity and food intake in the morning and evening only. Read More

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http://dx.doi.org/10.5334/jcr.afDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831298PMC
June 2015
4 Reads

Diurnal Preference Predicts Phase Differences in Expression of Human Peripheral Circadian Clock Genes.

J Circadian Rhythms 2015 Jun 5;13. Epub 2015 Jun 5.

Department of Biology, Colgate University, NY USA.

Background: Circadian rhythms play an integral role in human behavior, physiology and health. Individual differences in daily rhythms (chronotypes) can affect individual sleep-wake cycles, activity patterns and behavioral choices. Diurnal preference, the tendency towards morningness or eveningness among individuals, has been associated with interpersonal variation in circadian clock-related output measures, including body temperature, melatonin levels and clock gene mRNA in blood, oral mucosa, and dermal fibroblast cell cultures. Read More

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http://dx.doi.org/10.5334/jcr.aeDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832819PMC
June 2015
17 Reads

A Functional Data Analysis Approach for Circadian Patterns of Activity of Teenage Girls.

J Circadian Rhythms 2015 Apr 8;13. Epub 2015 Apr 8.

Health Behavior Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.

Background: Longitudinal or time-dependent activity data are useful to characterize the circadian activity patterns and to identify physical activity differences among multiple samples. Statistical methods designed to analyze multiple activity sample data are desired, and related software is needed to perform data analysis.

Methods: This paper introduces a functional data analysis (fda) approach to perform a functional analysis of variance (fANOVA) for longitudinal circadian activity count data and to investigate the association of covariates such as weight or body mass index (BMI) on physical activity. Read More

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http://dx.doi.org/10.5334/jcr.acDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831276PMC
April 2015
13 Reads

Rhythmic Trafficking of TRPV2 in the Suprachiasmatic Nucleus is Regulated by Prokineticin 2 Signaling.

J Circadian Rhythms 2015 Apr 1;13. Epub 2015 Apr 1.

Department of Pharmacology, University of California, Irvine.

The mammalian circadian clock is composed of single-cell oscillators. Neurochemical and electrical signaling among these oscillators is important for the normal expression of circadian rhythms. Prokineticin 2 (PK2), encoding a cysteine-rich secreted protein, has been shown to be a critical signaling molecule for the regulation of circadian rhythms. Read More

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http://www.jcircadianrhythms.com/articles/10.5334/jcr.ad/
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http://dx.doi.org/10.5334/jcr.adDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832818PMC
April 2015
9 Reads

Circadian Pattern of Melatonin MT1 and MT2 Receptor Localization in the Rat Suprachiasmatic Nucleus.

J Circadian Rhythms 2015 Mar 10;13. Epub 2015 Mar 10.

Department of Biomedical Sciences, Creighton University, United States.

The suprachiasmatic nucleus (SCN) is the master circadian pacemaker. The pineal hormone melatonin is involved in the regulation of circadian phase. As a part of the circadian system, its synthesis and secretion is under SCN control. Read More

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http://www.jcircadianrhythms.com/articles/10.5334/jcr.ab/
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http://dx.doi.org/10.5334/jcr.abDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831275PMC
March 2015
5 Reads

Daily blood feeding rhythms of laboratory-reared North American Culex pipiens.

J Circadian Rhythms 2014 Jan 22;12(1). Epub 2014 Jan 22.

Department of Entomology, North Carolina State University, Raleigh, NC 27607, USA.

Background: Blood feeding by free-living insect vectors of disease is rhythmic and can be used to predict when infectious bites will occur. These daily rhythms can also be targeted by control measures, as in insecticide-treated nets. Culex pipiens form pipiens and C. Read More

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http://dx.doi.org/10.1186/1740-3391-12-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904402PMC
January 2014
4 Reads

Daily cycling of nitric oxide synthase (NOS) in the hippocampus of pigeons (C. livia).

J Circadian Rhythms 2013 Nov 1;11(1):12. Epub 2013 Nov 1.

Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Rua Monteiro Lobato, 255, Campinas, São Paulo 13083-970, Brazil.

Background: Nitric oxide synthase (NOS) is essential for the synthesis of nitric oxide (NO), a non-conventional neurotransmitter with an important role in synaptic plasticity underlying processes of hippocampus-dependent memory and in the regulation of biological clocks and circadian rhythms. Many studies have shown that both the NOS cytosolic protein content and its enzymatic activity present a circadian variation in different regions of the rodent brain, including the hippocampus. The present study investigated the daily variation of NOS enzymatic activity and the cytosolic content of nNOS in the hippocampus of pigeons. Read More

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http://dx.doi.org/10.1186/1740-3391-11-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177212PMC
November 2013
5 Reads

Synaptophysin is involved in resetting of the mammalian circadian clock.

J Circadian Rhythms 2013 Oct 1;11(1):11. Epub 2013 Oct 1.

Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg, Switzerland.

Background: Mammals can adapt to changing light/dark conditions by advancing or delaying their circadian clock phase. Light pulses evoke changes in gene expression and neuronal activity in the suprachiasmatic nuclei (SCN), the central pacemaker of the circadian system. Alterations in neuronal activity are partially mediated by changes in synaptic vesicle (SV) fusion at the presynaptic membrane, which modulates release of neurotransmitters. Read More

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http://dx.doi.org/10.1186/1740-3391-11-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851196PMC
October 2013
8 Reads

An out-of-lab trial: a case example for the effect of intensive exercise on rhythms of human clock gene expression.

J Circadian Rhythms 2013 Sep 3;11(1):10. Epub 2013 Sep 3.

The Research Institute for Time Studies, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8511, Japan.

Background: Although out-of-lab investigation of the human circadian clock at the clock gene expression level remains difficult, a recent method using hair follicle cells might be useful. While exercise may function as an entrainment cue for circadian rhythms, it remains unclear whether exercise affects human circadian clock gene expression.

Methods: Efforts to observe apparent effects of exercise on clock gene expression require that several specific conditions be met: intense exercise should be habitually performed at a relatively uncommon time of day over an extended period; and any relative phase shift thereby observed should be validated by comparison of exercise and no-exercise periods. Read More

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http://dx.doi.org/10.1186/1740-3391-11-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846773PMC
September 2013
5 Reads

Circadian behavior of mice deficient in PER1/PML or PER2/PML.

J Circadian Rhythms 2013 Aug 28;11(1). Epub 2013 Aug 28.

Department of Biochemistry and Molecular Biology, Medical School, University of Texas Health Science Center-Houston, Houston, TX, 77030, USA.

Background: Our recent studies demonstrate that the murine homolog of the human tumor suppressor promyelocytic leukemia (PML) regulates circadian behavior of mice. To further gather insight into PML's contribution to circadian behavior, we generated two strains of mice deficient in one of the two period (Per) genes and the PML gene, with Per1-/-/Pml-/- and Per2-/-/Pml-/- genotypes.

Results: Here we report the circadian behavior of these mice based on wheel-running behavioral analysis. Read More

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http://dx.doi.org/10.1186/1740-3391-11-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765970PMC
August 2013
4 Reads

Diurnal and nutritional adjustments of intracellular Ca2+ release channels and Ca2+ ATPases associated with restricted feeding schedules in the rat liver.

J Circadian Rhythms 2013 Aug 20;11(1). Epub 2013 Aug 20.

Departamento de Neurobiología Molecular y Celular, Instituto de Neurobiología, UNAM-Juriquilla, Boulevard Juriquilla #3001, Apdo, Postal 1-1141, Querétaro, QRO 76230, México.

Background: Intracellular calcium is a biochemical messenger that regulates part of the metabolic adaptations in the daily fed-fast cycle. The aim of this study was to characterize the 24-h variations of the liver ryanodine and IP3 receptors (RyR and IP3R) as well as of the endoplasmic-reticulum and plasma-membrane Ca2+-ATPases (SERCA and PMCA) in daytime restricted feeding protocol.

Methods: A biochemical and immunohistochemical approach was implemented in this study: specific ligand-binding for RyR and IP3R, enzymatic activity (SERCA and PMCA), and protein levels and zonational hepatic-distribution were determined by immunoblot and immunohistochemistry respectively under conditions of fasting, feeding, and temporal food-restriction. Read More

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http://dx.doi.org/10.1186/1740-3391-11-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850936PMC
August 2013
3 Reads

Methods for serial analysis of long time series in the study of biological rhythms.

J Circadian Rhythms 2013 Jul 18;11(1). Epub 2013 Jul 18.

Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Avenue Joan XXIII 27-31, 08028, Barcelona, Spain.

When one is faced with the analysis of long time series, one often finds that the characteristics of circadian rhythms vary with time throughout the series. To cope with this situation, the whole series can be fragmented into successive sections which are analyzed one after the other, which constitutes a serial analysis. This article discusses serial analysis techniques, beginning with the characteristics that the sections must have and how they can affect the results. Read More

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http://dx.doi.org/10.1186/1740-3391-11-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723718PMC
July 2013
3 Reads

Maximum entropy spectral analysis for circadian rhythms: theory, history and practice.

Authors:
Harold B Dowse

J Circadian Rhythms 2013 Jul 11;11(1). Epub 2013 Jul 11.

Department of Mathematics and Statistics, School of Biology and Ecology, 5751 Murray Hall, University of Maine, Orono ME 04469, USA.

There is an array of numerical techniques available to estimate the period of circadian and other biological rhythms. Criteria for choosing a method include accuracy of period measurement, resolution of signal embedded in noise or of multiple periodicities, and sensitivity to the presence of weak rhythms and robustness in the presence of stochastic noise. Maximum Entropy Spectral Analysis (MESA) has proven itself excellent in all regards. Read More

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http://dx.doi.org/10.1186/1740-3391-11-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723481PMC
July 2013
5 Reads

Wavelet analysis of circadian and ultradian behavioral rhythms.

Authors:
Tanya L Leise

J Circadian Rhythms 2013 Jul 1;11(1). Epub 2013 Jul 1.

Department of Mathematics, Amherst College, Amherst, MA 01002 USA.

: We review time-frequency methods that can be useful in quantifying circadian and ultradian patterns in behavioral records. These records typically exhibit details that may not be captured through commonly used measures such as activity onset and so may require alternative approaches. For instance, activity may involve multiple bouts that vary in duration and magnitude within a day, or may exhibit day-to-day changes in period and in ultradian activity patterns. Read More

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http://dx.doi.org/10.1186/1740-3391-11-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717080PMC
July 2013
4 Reads

A tryptophan-rich breakfast and exposure to light with low color temperature at night improve sleep and salivary melatonin level in Japanese students.

J Circadian Rhythms 2013 25;11. Epub 2013 May 25.

Laboratory of Environmental Physiology, Graduate School of Integrated Arts and Sciences, Kochi University, Kochi, Japan.

Background: Epidemiological studies in Japan have documented an association between morning type and a tryptophan-rich breakfast followed by exposure to sunlight in children. The association may be mediated by enhanced melatonin synthesis, which facilitates sleep at night. However, melatonin is inhibited by artificial light levels with high color-temperature common in Japanese homes at night. Read More

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http://dx.doi.org/10.1186/1740-3391-11-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691879PMC
May 2014
11 Reads

FMR1, circadian genes and depression: suggestive associations or false discovery?

J Circadian Rhythms 2013 Mar 23;11(1). Epub 2013 Mar 23.

Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0603, USA.

Background: There are several indications that malfunctions of the circadian clock contribute to depression. To search for particular circadian gene polymorphisms associated with depression, diverse polymorphisms were genotyped in two samples covering a range of depressed volunteers and participants with normal mood.

Methods: Depression mood self-ratings and DNA were collected independently from a sample of patients presenting to a sleep disorders center (1086 of European origin) and from a separate sample consisting of 399 participants claiming delayed sleep phase symptoms and 406 partly-matched controls. Read More

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http://dx.doi.org/10.1186/1740-3391-11-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627611PMC
March 2013
6 Reads

Characterization of locomotor activity circadian rhythms in athymic nude mice.

J Circadian Rhythms 2013 Feb 1;11(1). Epub 2013 Feb 1.

Laboratorio de Cronobiología, Universidad Nacional de Quilmes, Nacional de Quilmes, R, S, Peña 180, Bernal, Buenos Aires, 1876, Argentina.

Unlabelled:

Background: The relation between circadian dysregulation and cancer incidence and progression has become a topic of major interest over the last decade. Also, circadian timing has gained attention regarding the use of chronopharmacology-based therapeutics. Given its lack of functional T lymphocytes, due to a failure in thymus development, mice carrying the Foxn1(Δ/Δ) mutation (nude mice) have been traditionally used in studies including implantation of xenogeneic tumors. Read More

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http://dx.doi.org/10.1186/1740-3391-11-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570476PMC
February 2013
4 Reads

Journal of Circadian Rhythms: 10th anniversary.

J Circadian Rhythms 2013 Jan 4;11(1). Epub 2013 Jan 4.

Circadian Rhythm Laboratory, University of South Carolina, Walterboro, SC, 29488, USA.

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http://dx.doi.org/10.1186/1740-3391-11-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558342PMC
January 2013
4 Reads

Investigation of a non-invasive method of assessing the equine circadian clock using hair follicle cells.

J Circadian Rhythms 2012 Oct 5;10(1). Epub 2012 Oct 5.

School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland.

Unlabelled:

Background: A comprehensive understanding of the equine circadian clock involves the evaluation of circadian clock gene expression. A non-invasive and effective method for detecting equine clock gene expression has yet to be established. Currently, research surrounding this area has relied on collecting tissue biopsies or blood samples that can often be costly, time consuming and uncomfortable for the animal. Read More

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http://dx.doi.org/10.1186/1740-3391-10-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514281PMC
October 2012
6 Reads

The effects of lighting conditions and food restriction paradigms on locomotor activity of common spiny mice, Acomys cahirinus.

J Circadian Rhythms 2012 Sep 9;10(1). Epub 2012 Sep 9.

Department of Biological Sciences, Plymouth State University, Plymouth, NH 03264, UK.

Background: An endogenous circadian clock controls locomotor activity in common spiny mice (Acomys cahirinus). However, little is known about the effects of constant light (LL) on this activity or about the existence of an additional food entrainable clock. A series of experiments were performed to investigate the effects of LL and DD on tau and activity levels. Read More

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https://www.jcircadianrhythms.com/article/10.1186/1740-3391-
Publisher Site
http://dx.doi.org/10.1186/1740-3391-10-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485179PMC
September 2012
4 Reads

Diurnal-and sex-related difference of metallothionein expression in mice.

J Circadian Rhythms 2012 Jul 24;10(1). Epub 2012 Jul 24.

Dept of Pharmacology and Key Lab of Basic Pharmacology of Guizhou, Zunyi Medical College, Zunyi, Guizhou 563003, China.

Background: Metallothionein (MT) is a small, cysteine-rich, metal-binding protein that plays an important role in protecting against toxicity of heavy metal and chemicals. This study was aimed to define diurnal and sex variation of MT in mice.

Methods: Adult mice were maintained in light- and temperature-controlled facilities for 2 weeks with light on at 8:00 and light off at 20:00. Read More

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http://dx.doi.org/10.1186/1740-3391-10-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585924PMC
July 2012
4 Reads

Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism.

J Circadian Rhythms 2012 May 15;10(1). Epub 2012 May 15.

Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Wakamatsu-cho 2-2, Shinjuku-ku, Tokyo, 162-8480, Japan.

Background: Recent studies on humans and rodents have suggested that the timing of food intake plays an important role in circadian regulation and metabolic health. Consumption of high-fat foods during the inactive period or at the end of the awake period results in weight gain and metabolic syndrome in rodents. However, the distinct effects of breakfast size and the breakfast/dinner size ratio on metabolic health have not yet been fully examined in mice. Read More

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http://dx.doi.org/10.1186/1740-3391-10-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434038PMC
May 2012
6 Reads

Chronotolerance study of the antiepileptic drug valproic acid in mice.

J Circadian Rhythms 2012 May 10;10. Epub 2012 May 10.

Laboratoire de Pharmacologie, Faculté de Médecine, Université de Monastir, Monastir, Tunisia.

Background: Valproic acid (VPA) is an antiepileptic drug widely used for the treatment of absence seizures and generalized tonic-clonic seizures. The present work aims to study whether VPA-induced toxicity varies according to the dosing-time in the 24 hour-scale.

Methods: The influence of dosing-time on tolerance to VPA was investigated in 120 male Swiss mice synchronized under a light-dark cycle (12:12). Read More

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http://dx.doi.org/10.1186/1740-3391-10-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431278PMC
May 2012
18 Reads