5,652 results match your criteria Journal of Child Neurology[Journal]


A Proof-of-Principle, Case-Control Study to Compensate for Potential Carbohydrates in Liquid Antiseizure Drugs in Children on the Ketogenic Diet.

J Child Neurol 2019 Feb 20:883073819831179. Epub 2019 Feb 20.

1 Departments of Pediatrics and Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA.

Introduction:: Since its creation, patients on ketogenic diet are told to avoid liquid medications due to theoretical concerns of "hidden" carbohydrates. However, switching from liquid to tablet formulations can be problematic, especially for infants and young children. We theorized that increasing the daily ketogenic ratio might compensate for liquid antiseizure drug carbohydrates. Read More

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http://dx.doi.org/10.1177/0883073819831179DOI Listing
February 2019

Levels of Melatonin in Continuous Spikes and Waves During Sleep.

J Child Neurol 2019 Feb 14:883073819828580. Epub 2019 Feb 14.

1 Department of Pediatric Neurology, School of Medicine, Celal Bayar University, Manisa, Turkey.

Levels of melatonin have been reported before in children with epilepsy, but such has not been reported to date in those with continuous spikes and waves during sleep. The aim of the present study was to assess serum melatonin levels and melatonin circadian rhythm in patients with continuous spikes and waves during sleep and epilepsy. Serum melatonin was measured in 39 children stratified into 3 groups. Read More

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http://dx.doi.org/10.1177/0883073819828580DOI Listing
February 2019

Stormorken Syndrome: A Rare Cause of Myopathy With Tubular Aggregates and Dystrophic Features.

J Child Neurol 2019 Feb 14:883073819829389. Epub 2019 Feb 14.

1 Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Stormorken syndrome is a rare genetic disorder (MIM 185070) first reported in 1983 with thrombocytopenia, muscle weakness, asplenia, and miosis caused by a mutation of the stromal interaction molecule 1 ( STIM1) gene. The muscle weakness is caused by a myopathy with tubular aggregate formation. We report a family in which both child and mother presented with proximal muscle weakness and thrombocytopenia. Read More

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http://dx.doi.org/10.1177/0883073819829389DOI Listing
February 2019

Combined Conventional and Amplitude-Integrated EEG Monitoring in Neonates: A Prospective Study.

J Child Neurol 2019 Feb 14:883073819829256. Epub 2019 Feb 14.

1 Division of Neurology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.

Background/objective:: Seizure monitoring via amplitude-integrated EEG is standard of care in many neonatal intensive care units; however, conventional EEG is the gold standard for seizure detection. We compared the diagnostic yield of amplitude-integrated EEG interpreted at the bedside, amplitude-integrated EEG interpreted by an expert, and conventional EEG.

Methods:: Neonates requiring seizure monitoring received amplitude-integrated EEG and conventional EEG in parallel. Read More

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http://dx.doi.org/10.1177/0883073819829256DOI Listing
February 2019
2 Reads

Lysosomal Leukodystrophies Lysosomal Storage Diseases Associated With White Matter Abnormalities.

J Child Neurol 2019 Feb 13:883073819828587. Epub 2019 Feb 13.

1 University of Florida, Departments of Pediatrics, Division of Genetics and Metabolism, Neuroscience and Molecular Genetics & Microbiology, Gainesville, FL, USA.

The leukodystrophies are a group of genetic metabolic diseases characterized by an abnormal development or progressive degeneration of the myelin sheath. The myelin is a complex sheath composed of several macromolecules covering axons as an insulator. Each of the leukodystrophies is caused by mutations in genes encoding enzymes that are involved in myelin production and maintenance. Read More

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http://dx.doi.org/10.1177/0883073819828587DOI Listing
February 2019
1 Read

Comparing Single-Photon Emission Computed Tomography (SPECT), Electroencephalography (EEG), and Magneto-encephalography (MEG) Seizure Localizations in Pediatric Cases of Laser Ablation.

J Child Neurol 2019 Feb 12:883073818822353. Epub 2019 Feb 12.

3 University of Texas Dell Medical School, Austin, TX, USA.

Intractable epilepsy may have a more severe effect on children in comparison to adults because the motor, sensorial, and cognitive functions of children are still undergoing development. For this same reason, however, children maintain a greater potential for recovery from intractable epilepsy because of the remaining cerebral plasticity. Thus, after 2 unsuccessful antiepileptic medications, surgical intervention is recommended. Read More

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http://dx.doi.org/10.1177/0883073818822353DOI Listing
February 2019

Adjunctive Perampanel Oral Suspension in Pediatric Patients From ≥2 to <12 Years of Age With Epilepsy: Pharmacokinetics, Safety, Tolerability, and Efficacy.

J Child Neurol 2019 Feb 10:883073819827407. Epub 2019 Feb 10.

12 Formerly: Eisai Neurology Business Group, Eisai Inc., Woodcliff Lake, NJ, USA.

Study 232, an open-label pilot study with an extension phase, evaluated the pharmacokinetics and preliminary safety/tolerability and efficacy of adjunctive perampanel oral suspension (≤0.18 mg/kg/d) in epilepsy patients aged ≥2 to <12 years. Patients were grouped into cohorts 1 (aged ≥7 to <12 years) and 2 (aged ≥2 to <7 years). Read More

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http://dx.doi.org/10.1177/0883073819827407DOI Listing
February 2019
2 Reads

A Novel Treatment Strategy for Severe Guillain-Barré Syndrome: Zipper Method.

J Child Neurol 2019 Jan 29:883073819826225. Epub 2019 Jan 29.

4 Pediatric Intensive Care Unit, Hacettepe University İhsan Doğramacı Children's Hospital, Ankara, Turkey.

Objective:: Intravenous immunoglobulin and plasma exchange are proven treatments for Guillain-Barré syndrome. Despite these treatments, the prognosis for severe Guillain-Barré syndrome is still not satisfactory. This article seeks for a logical timing for plasma exchange-intravenous immunoglobulin synergy, which may improve outcome in severe Guillain-Barré syndrome requiring mechanical ventilation. Read More

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http://dx.doi.org/10.1177/0883073819826225DOI Listing
January 2019
7 Reads

Pregabalin as Adjunctive Treatment for Focal Onset Seizures in Pediatric Patients: A Randomized Controlled Trial.

J Child Neurol 2019 Jan 27:883073818821035. Epub 2019 Jan 27.

7 First Department of Pediatrics, Semmelweis University, Budapest, Hungary.

Efficacy and safety of pregabalin as adjunctive treatment for children (aged 4-16 years) with partial-onset seizures, hereafter termed focal onset seizures for this study, was evaluated. This double-blind, randomized, placebo-controlled, international study had 3 phases: 8-week baseline, 12-week double-blind treatment (2-week dose escalation; 10-week fixed dose), and 1-week taper. Selection criteria included experiencing focal onset seizures and receiving a stable regimen of 1 to 3 antiepileptic drugs. Read More

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http://dx.doi.org/10.1177/0883073818821035DOI Listing
January 2019
2 Reads

Atypical Clinical Presentations of Pediatric Acute Immune-Mediated Polyneuropathy.

J Child Neurol 2019 Jan 23:883073818825213. Epub 2019 Jan 23.

2 Institute of Child Neurology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in children. During the acute phase, the disorder can be life-threatening by involving the respiratory muscles and the autonomic nervous system. Nevertheless, the prognosis is good, and most children achieve full recovery. Read More

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http://journals.sagepub.com/doi/10.1177/0883073818825213
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http://dx.doi.org/10.1177/0883073818825213DOI Listing
January 2019
5 Reads

Pharmacologic Treatments for Sleep Disorders in Children: A Systematic Review.

J Child Neurol 2019 Jan 23:883073818821030. Epub 2019 Jan 23.

1 Department of Medical Informatics and Clinical Epidemiology, Pacific Northwest Evidence-based Practice Center, Oregon Health & Science University, Portland, OR, USA.

Sleep problems are common in children, especially those with neurodevelopmental disorders, and can lead to consequences in behavior, functioning, and quality of life. We systematically reviewed the efficacy and harms of pharmacologic treatments for sleep disorders in children and adolescents. We searched MEDLINE, Cochrane library databases, and PsycINFO through June 2018. Read More

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http://dx.doi.org/10.1177/0883073818821030DOI Listing
January 2019
8 Reads

Comparing the Acute Presentation of Sport-Related Concussion in the Pediatric and Adult Populations.

J Child Neurol 2019 Jan 22:883073818825031. Epub 2019 Jan 22.

1 The Sports Neurology Clinic, Brighton, MI, USA.

Despite growing research on concussion, there is minimal evidence comparing the acute presentation of concussion between pediatric and adult patients. This cross-sectional study compares injury characteristics, symptoms, and neurologic examination in sport-related concussion based on age. Patients presenting to an outpatient sports neurology clinic for initial assessment of concussion within 7 days of injury were divided into 2 groups, 18 and older (n = 28) and 17 and younger (n = 107). Read More

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http://dx.doi.org/10.1177/0883073818825031DOI Listing
January 2019
3 Reads

Trouble Falling Asleep After Concussion Is Associated With Higher Symptom Burden Among Children and Adolescents.

J Child Neurol 2019 Jan 22:883073818824000. Epub 2019 Jan 22.

3 The Micheli Center for Sports Injury Prevention, Waltham, MA, USA.

Our objective was to identify factors associated with trouble falling asleep postconcussion. Patients seen for care after sport-related concussion were assessed ≤10 days postinjury and were between 6 and 19 years of age. Outcomes included symptoms (Post-Concussion Symptom Scale), postural steadiness, missed school, and medical history. Read More

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http://dx.doi.org/10.1177/0883073818824000DOI Listing
January 2019
1 Read

Identifying Factors Associated With Severe Intellectual Disabilities in Teenagers With Cerebral Palsy Using a Predictive Learning Model.

J Child Neurol 2019 Jan 22:883073818822358. Epub 2019 Jan 22.

1 Department of Pediatric Orthopaedic Surgery, Lenval University Pediatric Hospital of Nice, Nice, France.

Background:: Intellectual disability and impaired adaptive functioning are common in children with cerebral palsy, but there is a lack of studies assessing these issues in teenagers with cerebral palsy. Therefore, the aim of this study was to develop and test a predictive machine learning model to identify factors associated with intellectual disability in teenagers with cerebral palsy.

Methods:: This was a multicenter controlled cohort study of 91 teenagers with cerebral palsy (53 males, 38 females; mean age ± SD = 17 ± 1 y; range: 12-18 y). Read More

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http://dx.doi.org/10.1177/0883073818822358DOI Listing
January 2019
2 Reads
1.666 Impact Factor

GABA Transaminase Deficiency With Survival Into Adulthood.

J Child Neurol 2019 Mar 15;34(4):216-220. Epub 2019 Jan 15.

3 Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

γ-Aminobutyric acid (GABA)-transaminase deficiency is an ultra-rare disorder of GABA metabolism that was described for decades as an early-onset epileptic encephalopathy plus movement disorder and hypersomnolence with mortality in early childhood. We report 2 affected siblings in adolescence and adulthood, both with profound developmental impairment, intractable epilepsy, movement disorder, and behavioral fluctuations. This considerably expands the phenotype and longevity of this inherited neurotransmitter disease. Read More

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http://dx.doi.org/10.1177/0883073818823359DOI Listing
March 2019
2 Reads

Pattern of Brain Injury Predicts Long-Term Epilepsy Following Neonatal Encephalopathy.

J Child Neurol 2019 Jan 15:883073818822361. Epub 2019 Jan 15.

1 Department of Pediatrics, Neurology, University of British Columbia and BC Children's Hospital, Vancouver, British Columbia, Canada.

Objective:: To determine if patterns of hypoxic-ischemic brain injury on magnetic resonance imaging (MRI) in term newborns predict subsequent childhood epilepsy. Methods: This retrospective cohort study includes term newborns with encephalopathy (n = 181) born between 2004-2012 and admitted to British Columbia Children's Hospital. MRI was performed between 3 and 5 days of age. Read More

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http://dx.doi.org/10.1177/0883073818822361DOI Listing
January 2019
2 Reads
1.666 Impact Factor

Parents' Experiences of Information and Decision Making in the Care of Their Child With Severe Spinal Muscular Atrophy: A Population Survey.

J Child Neurol 2019 Jan 15:883073818822900. Epub 2019 Jan 15.

2 Ersta Sköndal Bräcke University College, Department of Health Care Sciences, Palliative Research Centre, Stockholm, Sweden.

Objective:: This study aims to assess the experiences and wishes of parents of children with severe spinal muscular atrophy regarding information and decision-making throughout the course of the illness.

Study Design:: A full population survey, conducted in 2015, among parents of children with severe spinal muscular atrophy who were born in Denmark between January 1, 2003, and December 31, 2013. We used a study-specific questionnaire with items about experiences and wishes concerning the provision of information about diagnosis, treatment, and end-of-life care. Read More

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http://dx.doi.org/10.1177/0883073818822900DOI Listing
January 2019
1 Read

The Full Outline of UnResponsiveness (FOUR) Score and Its Use in Outcome Prediction: A Scoping Review of the Pediatric Literature.

J Child Neurol 2019 Jan 10:883073818822359. Epub 2019 Jan 10.

3 Clinician Investigator Program, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

The Full Outline of UnResponsiveness (FOUR) score is a neurologic assessment score. Its benefit over pre-existing scores is its evaluation of brainstem reflexes and respiratory pattern. Our goal was to perform a scoping systematic review of the literature on the application of the FOUR score within pediatric patients. Read More

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http://journals.sagepub.com/doi/10.1177/0883073818822359
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http://dx.doi.org/10.1177/0883073818822359DOI Listing
January 2019
9 Reads

Severe Herpes Zoster Following Varicella Vaccination in Immunocompetent Young Children.

J Child Neurol 2019 Jan 10:883073818821498. Epub 2019 Jan 10.

4 Division of Child Neurology, Children's Hospital, University of Iowa, Iowa City, IA, USA.

Varicella vaccination is now virtually universal in North America, as well as in some European and Asian countries. Since varicella vaccine is a live attenuated virus, the virus replicates in the skin after administration and can travel via sensory nerves or viremia to become latent in the dorsal root ganglia. In some immunized children, virus reactivates within a few months to a few years to cause the dermatomal exanthem known as herpes zoster (shingles). Read More

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http://dx.doi.org/10.1177/0883073818821498DOI Listing
January 2019
6 Reads

Genetic Testing Practices of Genetic Counselors, Geneticists, and Pediatric Neurologists With Regard to Childhood-Onset Neurogenetic Conditions.

J Child Neurol 2019 Jan 4:883073818821036. Epub 2019 Jan 4.

2 Genetic Counseling Program, University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.

Identifying genetic diagnoses for neurologic conditions with a considerable hereditary component, such as autism spectrum disorder, intellectual disability, and epilepsy, is critical to providing proper medical management for patients and their families. However, many patients with these conditions are not tested appropriately or receive no genetic testing at all. The current study was designed to characterize the genetic testing practices of the providers most likely to evaluate or order genetic testing for these patients: pediatric neurologists, geneticists, and genetic counselors. Read More

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http://dx.doi.org/10.1177/0883073818821036DOI Listing
January 2019
1 Read

Long-term Sequelae of Pediatric Bickerstaff Brainstem Encephalitis Includes Autonomic and Sleep Dysregulation.

J Child Neurol 2019 Jan 3:883073818820488. Epub 2019 Jan 3.

1 Division of Child Neurology, Department of Neurology, Stanford University, Palo Alto, CA, USA.

Bickerstaff brainstem encephalitis is a rare, immune-mediated disorder of the brainstem and peripheral nervous system. Published knowledge of pediatric Bickerstaff brainstem encephalitis focuses on the acute phase of the disease process. This study evaluated long-term neurologic and immune sequelae of Bickerstaff brainstem encephalitis in children. Read More

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http://dx.doi.org/10.1177/0883073818820488DOI Listing
January 2019
3 Reads

An Objective Method for Evaluating Next-Generation Sequencing Panels.

J Child Neurol 2018 Dec 20:883073818815036. Epub 2018 Dec 20.

1 Department of Pediatrics, Section of Neurology, University of Colorado Denver, Aurora, CO, USA.

Purpose:: Next-generation sequencing panels are particularly useful in identifying genetic diagnoses in patients with nonspecific clinical findings by allowing for analysis of many genes at once. The purpose of this study was to develop a simple, objective system to evaluate the quality of available next-generation sequencing panels.

Methods:: A list of potentially important features of next-generation sequencing panels generated from the literature was evaluated for accessibility and objectivity and distilled to a "core" set of quality features. Read More

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http://dx.doi.org/10.1177/0883073818815036DOI Listing
December 2018
1 Read

Headaches in Loyes-Dietz Syndrome.

Authors:
Debopam Samanta

J Child Neurol 2018 Dec 19:883073818815039. Epub 2018 Dec 19.

1 Department of Pediatrics, Neurology Section, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Loeys-Dietz syndrome is a rare connective tissue disorder characterized by cardiovascular, craniofacial, skeletal, and neurocognitive abnormalities. Recurrent headaches may constitute the neurological presentation of Loyes-Dietz syndrome in the absence of an intracranial aneurysm, subarachnoid hemorrhage, or dissection. The etiology of headaches occurring in Loeys-Dietz syndrome can be diverse but underrecognized and underreported. Read More

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http://dx.doi.org/10.1177/0883073818815039DOI Listing
December 2018
7 Reads

Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis.

J Child Neurol 2018 Dec 17:883073818815041. Epub 2018 Dec 17.

19 Pediatric Multiple Sclerosis Center at New York University Langone Medical Center, New York, NY, USA.

Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric multiple sclerosis (n = 467) were not delayed in walking or using 2-word phrases compared to healthy controls (n = 428) (2. Read More

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http://dx.doi.org/10.1177/0883073818815041DOI Listing
December 2018
8 Reads
1.666 Impact Factor

Bereaved Parents More Satisfied With the Care Given to Their Child With Severe Spinal Muscular Atrophy Than Nonbereaved.

J Child Neurol 2019 Feb 5;34(2):104-112. Epub 2018 Dec 5.

1 Ersta Sköndal Bräcke University College, Department of Health Care Sciences, Palliative Research Centre, Stockholm, Sweden.

Background And Aims:: Children with severe spinal muscular atrophy have complex care needs due to progressive muscle weakness, eventually leading to respiratory failure. To design a care system adapted to families' needs, more knowledge about parents' experience of care and its coordination between settings is required. This study explores (1) whether parents felt that health professionals took every opportunity to help the child feel as good as possible, (2) parents' satisfaction with various care settings, and (3) parents' satisfaction with coordination between settings. Read More

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http://dx.doi.org/10.1177/0883073818811544DOI Listing
February 2019
7 Reads

HaNDL Syndrome: Case Report and Literature Review.

J Child Neurol 2019 Mar 5;34(3):161-167. Epub 2018 Dec 5.

1 Department of Pediatric Neurology, Massachusetts General Hospital, Boston, MA, USA.

Headache and Neurologic Deficits with cerebrospinal fluid Lymphocytosis (HaNDL) syndrome is a rare stroke mimicker characterized by moderate to severe headache temporally associated with transient neurologic deficits, typically hemiparesis, hemisensory disturbance, and/or aphasia. Cerebrospinal fluid studies reveal a lymphocytosis and elevated protein. Episodes recur over a period no longer than 3 months. Read More

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http://dx.doi.org/10.1177/0883073818811546DOI Listing
March 2019
2 Reads

mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report.

J Child Neurol 2019 Mar 5;34(3):132-138. Epub 2018 Dec 5.

1 Division of Neurology, University of British Columbia, BC Children's Hospital, Vancouver, BC, Canada.

Hemimegalencephaly is a hamartomatous malformation of one hemisphere. Functional hemispherectomy, the definitive treatment, is associated with significant morbidity and mortality in early infancy. Dysregulation of the mTOR pathway can result in malformations of cortical development, and mTOR inhibitors can effectively reduce seizures in tuberous sclerosis complex. Read More

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http://dx.doi.org/10.1177/0883073818813238DOI Listing
March 2019
4 Reads

Joint Position Sense Testing in Young Children.

J Child Neurol 2018 Dec 5:883073818812348. Epub 2018 Dec 5.

3 Division of Pediatric Neurology, Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USA.

The standard physical examination evaluation for a proprioception abnormality depends upon the patient's ability to follow directions and respond to the examiner, a skill not yet developed in toddlers. This study demonstrates a new proprioception examination method that may allow for better localization of lesions and determines whether healthy toddlers would cooperate with this test. By placing stickers on children's hands, covering their eyes, and then moving their hands, the examiner can see whether the children reach for where their hands and stickers were previously located or to their new location, which serves as an indicator of proprioception ability. Read More

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http://dx.doi.org/10.1177/0883073818812348DOI Listing
December 2018
3 Reads

Thrombophilia Testing in High Pediatric Migraine Risk Children With Migraine.

J Child Neurol 2018 Nov 28:883073818811545. Epub 2018 Nov 28.

1 Pediatric Headache Clinic, Day Hospitalization Department, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

This study sought to investigate the need for thrombophilia screening in pediatric migraineurs. The cohort included 45/824 children (5.5%) aged 3-18 years with migraine who were tested for thrombophilia at a tertiary pediatric headache clinic. Read More

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http://dx.doi.org/10.1177/0883073818811545DOI Listing
November 2018
7 Reads

Biallelic Loss-of-Function Variants in AIMP1 Cause a Rare Neurodegenerative Disease.

J Child Neurol 2019 Feb 28;34(2):74-80. Epub 2018 Nov 28.

1 Departments of Neurology and Neurosurgery, Pediatrics and Human Genetics, McGill University, Montreal, Canada.

AIMP1/p43, is a noncatalytic component of the mammalian multi-tRNA synthetase complex that catalyzes the ligation of amino acids to their cognate tRNAs. AIMP1 is largely expressed in the central nervous system, where it is part of the regulatory machine of the neurofilament assembly, playing a crucial role in neuronal development and function. To date, nonsense mutations in AIMP1 have been associated with a primary neurodegenerative disorder consisting of cerebral atrophy, hypomyelination, microcephaly and epilepsy, whereas missense mutations have recently been linked to intellectual disability without neurodegeneration. Read More

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http://dx.doi.org/10.1177/0883073818811223DOI Listing
February 2019
2 Reads

Treatment-Related Costs of Childhood Epilepsy in Mainland China: A Preliminary Study in a Tertiary Pediatric Epilepsy Center.

J Child Neurol 2019 Feb 28;34(2):68-73. Epub 2018 Nov 28.

1 Department of Pediatrics, Peking University First Hospital, Beijing, China.

This study aimed to investigate the treatment-related annual cost of childhood epilepsy and its related factors in mainland China. A total of 244 cases were collected at the outpatient clinics of Peking University First Hospital Pediatrics from April 2010 to August 2013. The median annual epilepsy treatment-related costs per patient were estimated to be RMB7822 (US$1160), accounting for 43. Read More

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http://dx.doi.org/10.1177/0883073818811176DOI Listing
February 2019
1 Read

Increased Intracranial Pressure in Acute Disseminated Encephalomyelitis.

J Child Neurol 2019 Feb 27;34(2):99-103. Epub 2018 Nov 27.

2 Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.

Objective:: To assess the intracranial pressure in pediatric acute disseminated encephalomyelitis using spinal tap opening pressure on lumbar puncture, which is routinely performed as part of suspected acute disseminated encephalomyelitis workup. Compared to other cerebrospinal fluid parameters such as cell count, protein concentration, and presence of oligoclonal bands, cerebrospinal fluid opening pressure is infrequently recorded.

Methods:: A retrospective chart review of demographic, clinical, and laboratory data of children diagnosed with acute disseminated encephalomyelitis admitted to a tertiary referral hospital between 2005 and 2016. Read More

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http://dx.doi.org/10.1177/0883073818811541DOI Listing
February 2019
10 Reads

Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis.

J Child Neurol 2019 Jan 21;34(1):38-43. Epub 2018 Nov 21.

1 Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Background:: Efferent visual dysfunction in children could lead to impaired quality of life at home and school. Eye-tracking can detect subtle efferent dysfunction missed on bedside examination but has not been validated in the pediatric multiple sclerosis population.

Objective:: We sought to determine the feasibility of eye-tracking in children and associations with multiple sclerosis. Read More

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http://dx.doi.org/10.1177/0883073818807787DOI Listing
January 2019
21 Reads

Delineating the Clinical Spectrum Associated With Xq25q26.2 Duplications: Report of 2 Families and Review of the Literature.

J Child Neurol 2019 Feb 21;34(2):86-93. Epub 2018 Nov 21.

1 Department of Pathology, University of Utah, Salt Lake City, UT, USA.

To date, 13 patients with interstitial microduplications involving Xq25q26.2 have been reported. Here, we report 6 additional patients from 2 families with duplications involving Xq25q26. Read More

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http://dx.doi.org/10.1177/0883073818811454DOI Listing
February 2019
8 Reads

Clinical Use and Efficacy of Levetiracetam for Absence Epilepsies.

J Child Neurol 2019 Feb 21;34(2):94-98. Epub 2018 Nov 21.

2 Division of Pediatric Neurology, Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.

Background:: Levetiracetam is prescribed for a broad spectrum of seizure types but does not have a specific indication for absence epilepsy. We hypothesized that levetiracetam is commonly prescribed for children with absence epilepsies and evaluated the efficacy of this medication for absence epilepsy treatment in clinical practice. We also hypothesized that electroencephalographic (EEG) findings could help predict levetiracetam efficacy. Read More

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http://dx.doi.org/10.1177/0883073818811511DOI Listing
February 2019
10 Reads

Serum Interleukin-6 Level in Children With Attention-Deficit Hyperactivity Disorder (ADHD).

J Child Neurol 2019 Feb 15;34(2):61-67. Epub 2018 Nov 15.

3 Clinical Pathology, Kafr El-sheikh University Hospital, Faculty of Medicine, Kafr El-sheikh, Egypt.

Introduction:: Attention-deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder in children, but its specific etiology and pathophysiology are still incompletely understood.

Objectives:: This case-control study aimed to measure the level of serum interleukin-6 (IL-6) as a predictor of the immunologic status in children with ADHD, and to study its correlation with severity of symptoms.

Subjects And Methods:: 60 ADHD children who met the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, criteria for ADHD and 60 control children were subjected to complete history taking, clinical examination, and psychometric tests. Read More

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http://dx.doi.org/10.1177/0883073818809831DOI Listing
February 2019
9 Reads

Children Born With Congenital Zika Syndrome Display Atypical Gross Motor Development and a Higher Risk for Cerebral Palsy.

J Child Neurol 2019 Feb 13;34(2):81-85. Epub 2018 Nov 13.

3 University of Iowa Stead Family Department of Pediatrics, Iowa City, IA, USA.

Importance:: Congenital Zika syndrome virus infection is said to interfere in children's development.

Objective:: evaluate gross motor trajectories and the frequency of cerebral palsy in children with congenital Zika syndrome.

Design:: Cohort study applying the Alberta Infant Motor Scale (AIMS) and the Bayley III Scales in infants from 6 to 18 months of age. Read More

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http://dx.doi.org/10.1177/0883073818811234DOI Listing
February 2019
13 Reads

Telemedicine and Child Neurology.

J Child Neurol 2019 Jan 5;34(1):22-26. Epub 2018 Nov 5.

3 Departments of Neurology and Pediatrics, University of Washington, Seattle, WA, USA.

Over the past 2 decades, various telehealth technologies, in particular synchronous video teleconferencing between provider and patient, have been incorporated into the practice of neurology. The practice of child neurology is now starting to take advantage of these rapidly evolving resources. This review describes the evolution of tele-neurology, starting with adult tele-stroke services and expanding to the management of both adults and children with a variety of chronic neurologic disorders including epilepsy, headache, movement disorders, and neurodevelopmental disabilities. Read More

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http://dx.doi.org/10.1177/0883073818807516DOI Listing
January 2019
8 Reads

Yield of Emergent Neuroimaging in Patients With Sturge-Weber Syndrome Presenting With Acute Neurologic Symptoms.

J Child Neurol 2019 Jan 31;34(1):17-21. Epub 2018 Oct 31.

2 Department of Neurology, Dell Medical School, Austin, TX.

Background/aims:: Seizures, strokelike episodes, and headaches are common complications in patients with Sturge-Weber syndrome. Based on our experience, we hypothesized that patients with Sturge-Weber syndrome have frequent urgent neuroimaging studies when presenting acutely to the emergency department. In this study, we aimed to determine the incidence of acute imaging studies in this patient population and to evaluate the prevalence of findings such as acute intracranial hemorrhagic or ischemic strokes. Read More

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http://journals.sagepub.com/doi/10.1177/0883073818801635
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http://dx.doi.org/10.1177/0883073818801635DOI Listing
January 2019
14 Reads

Clinical Features of and Risk Factors for Hydrocephalus in Childhood Bacterial Meningitis.

J Child Neurol 2019 Jan 29;34(1):11-16. Epub 2018 Oct 29.

1 Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Objective:: To explore the clinical characteristics of and analyze the risk factors for hydrocephalus in children with bacterial meningitis.

Methods:: Retrospective study of a sample of children with bacterial meningitis seen on the pediatric service of Shengjing Hospital of China Medical University between January 1, 2010, and December 31, 2016.

Results:: Overall, 9. Read More

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http://dx.doi.org/10.1177/0883073818799155DOI Listing
January 2019
5 Reads
1.666 Impact Factor

Efficacy of Stiripentol and the Clinical Outcome in Dravet Syndrome.

J Child Neurol 2019 Jan 26;34(1):33-37. Epub 2018 Oct 26.

2 Division of Pediatric Neurology, Department of Pediatrics, Istanbul Medical Faculty, Istanbul, Turkey.

Dravet syndrome is a rare and progressive epileptic encephalopathy of infancy. Stiripentol reduces the seizure frequency in patients with Dravet syndrome. We evaluated the clinical characteristics of patients with Dravet syndrome and their response to stiripentol. Read More

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http://dx.doi.org/10.1177/0883073818811538DOI Listing
January 2019
9 Reads

Gait Variability, Not Walking Speed, Is Related to Cognition in Adolescents With Multiple Sclerosis.

J Child Neurol 2019 Jan 25;34(1):27-32. Epub 2018 Oct 25.

3 Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel.

Gait variability is associated with cognitive performance in people with central neurologic damage illnesses, which includes multiple sclerosis. However, presently, there have been no data available as to whether this association exists in adolescents with multiple sclerosis. Therefore, our objective was to investigate the association between gait variability and cognition in adolescents with multiple sclerosis encompassing 48 recently diagnosed adolescents with multiple sclerosis (26 girls; 22 boys), average age of 16. Read More

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http://journals.sagepub.com/doi/10.1177/0883073818808034
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http://dx.doi.org/10.1177/0883073818808034DOI Listing
January 2019
12 Reads
1.670 Impact Factor

A Review of MD STAR net's Research Contributions to Pediatric-Onset Dystrophinopathy in the United States; 2002-2017.

J Child Neurol 2019 Jan 22;34(1):44-53. Epub 2018 Oct 22.

8 Centers for Disease Control and Prevention, National Center for Birth Defects and Developmental Disabilities, DHDD, Rare Disorders and Health Outcomes team, Atlanta, GA, USA.

Population studies of rare disorders, such as Duchenne and Becker muscular dystrophies (dystrophinopathies), are challenging due to diagnostic delay and heterogeneity in disorder milestones. To address these challenges, the Centers for Disease Control and Prevention established the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STAR net) in 2002 in the United States. From 2002 to 2012, MD STAR net longitudinally tracked the prevalence, clinical, and health care outcomes of 1054 individuals born from 1982 to 2011 with pediatric-onset dystrophinopathy through medical record abstraction and survey data collection. Read More

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http://dx.doi.org/10.1177/0883073818801704DOI Listing
January 2019
2 Reads

Assessment of Efficacy of Oral Rehydration Salts in Children With Neurally Mediated Syncope of Different Hemodynamic Patterns.

J Child Neurol 2019 Jan 16;34(1):5-10. Epub 2018 Oct 16.

1 Department of Pediatric Cardiovasology, Children's Medical Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Objective:: To assess the efficacy of oral rehydration salts in children with neurally mediated syncope of different hemodynamic types.

Methods:: Children with unexplained syncope or pre-syncope who visited or were hospitalized between March 2012 and February 2015 were enrolled in the study. Checked by the head-up tilt test, 105 children (aged 4-18 years, with a mean age of 11. Read More

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http://dx.doi.org/10.1177/0883073818803035DOI Listing
January 2019
3 Reads

Novel Homozygous Deletion in STRADA Gene Associated With Polyhydramnios, Megalencephaly, and Epilepsy in 2 Siblings: Implications for Diagnosis and Treatment.

J Child Neurol 2018 Dec 12;33(14):925-929. Epub 2018 Oct 12.

2 Department of Neurology, Division of Child Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.

Mutations in the STE20-related kinase adaptor α ( STRADA) gene have been reported to cause an autosomal recessive neurodevelopmental disorder characterized by infantile-onset epilepsy, developmental delay, and craniofacial dysmorphisms. To date, there have been 17 reported individuals diagnosed with STRADA mutations, 16 of which are from a single Old Order Mennonite cohort and share a deletion of exons 9-13. The remaining individual is of consanguineous Indian descent and has a homozygous single-base pair duplication. Read More

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http://dx.doi.org/10.1177/0883073818802724DOI Listing
December 2018
12 Reads

Brain Lesions as a Predictor of Therapeutic Outcomes of Hand Function in Infants With Unilateral Cerebral Palsy.

J Child Neurol 2018 Dec 11;33(14):918-924. Epub 2018 Oct 11.

3 Neuropediatric Unit, Shaare Zedek Medical Center.

Aim:: The present study aimed to investigate whether the response variability of infants to modified constraint-induced movement therapy and bimanual therapy are associated with different types of brain lesions.

Method:: Infants with unilateral cerebral palsy (N = 22) ages 8-15 months (mean = 10.95, standard deviation = 2. Read More

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http://dx.doi.org/10.1177/0883073818801632DOI Listing
December 2018
1 Read

High Mobility Group Protein B1 (HMGB1) and Interleukin-1β as Prognostic Biomarkers of Epilepsy in Children.

J Child Neurol 2018 Dec 10;33(14):909-917. Epub 2018 Oct 10.

2 Department of Neurology, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu PR China.

The present study examined whether serum biomarkers can predict the prognosis of childhood epilepsy, including seizure frequency, electroencephalographic (EEG) changes, and cognitive impairment. We measured serum concentrations of high mobility group protein B1 (HMGB1), interleukin-1β (IL-1β), S100 calcium-binding protein B (S-100B), glial fibrillary acidic protein (GFAP), and α1-antichymotrypsin (AACT) in 180 children with new-onset epilepsy and 40 healthy children. Cognitive evaluations were performed 18 months after the initial seizure episodes at diagnosis (ie, baseline visit). Read More

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http://journals.sagepub.com/doi/10.1177/0883073818801654
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http://dx.doi.org/10.1177/0883073818801654DOI Listing
December 2018
5 Reads

Novel Mutations in CLN5 of Chinese Patients With Neuronal Ceroid Lipofuscinosis.

J Child Neurol 2018 Nov 28;33(13):837-850. Epub 2018 Sep 28.

2 Department of Neurology, GuangDong 999 Brain Hospital, Guangzhou 510000, Guangdong, People's Republic of China.

Neuronal ceroid lipofuscinosis is a hereditary disease, and ceroid-lipofuscinosis neuronal protein 5 (CLN5) has been proved to be associated with neuronal ceroid lipofuscinosis. Here we report 3 patients from 2 families diagnosed with CLN5 neuronal ceroid lipofuscinosis. Whole genome sequencing of DNAs from 3 patients and their families revealed 3 novel homozygous mutations, including 1 deletion CLN5. Read More

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http://dx.doi.org/10.1177/0883073818789024DOI Listing
November 2018
13 Reads

Scope and Burden of Non-Standard of Care Hematopoietic Stem Cell Transplantation in Pediatric Leukodystrophy Patients.

J Child Neurol 2018 Dec 28;33(14):882-887. Epub 2018 Sep 28.

2 Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.

Inherited leukodystrophies are a group of diseases affecting central nervous system myelin that lead to death or significant health problems. Although for most leukodystrophies there are no curative treatments, for a handful of diseases hematopoietic stem cell transplantation (HSCT; bone marrow transplant) can stop disease progression, and if initiated in a timely fashion, prevent many or all neurologic and other systems involvement. However, HSCT is a complex procedure with significant morbidity and mortality risks. Read More

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http://journals.sagepub.com/doi/10.1177/0883073818798090
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http://dx.doi.org/10.1177/0883073818798090DOI Listing
December 2018
15 Reads

Encephaloduroarteriosynangiosis for Pediatric Moyamoya Disease: A Single-Center Experience With 67 Cases in China.

J Child Neurol 2018 Dec 24;33(14):901-908. Epub 2018 Sep 24.

1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.

The purpose of this study is to investigate the surgical results and long-term outcomes of encephaloduroarteriosynangiosis for moyamoya disease in pediatric patients. We performed a retrospective analysis of 67 pediatric patients with moyamoya disease who underwent encephaloduroarteriosynangiosis in Beijing Tiantan Hospital. The case series included 36 boys and 31 girls. Read More

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http://dx.doi.org/10.1177/0883073818798515DOI Listing
December 2018
3 Reads
1.670 Impact Factor