3,793 results match your criteria Journal of Chemotherapy[Journal]


Cefpodoxime proxetil as a therapeutic option in switching therapy for infective endocarditis in children: case reports and literature review.

J Chemother 2019 Apr 22:1-5. Epub 2019 Apr 22.

a University Hospital for Infectious Diseases, 'Dr. Fran Mihaljević ', Zagreb , Croatia.

Infective endocarditis (IE) is uncommon in children, affecting predominantly subjects with congenital heart disease (CHD) and patients with indwelling central lines. The principles of antibiotic treatment in paediatric population are similar to those in adults. Prolonged intravenous administration of bactericidal rather than bacteriostatic agents is preferred. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1603797DOI Listing

Quorum sensing pathways in Gram-positive and -negative bacteria: potential of their interruption in abating drug resistance.

J Chemother 2019 Apr 22:1-27. Epub 2019 Apr 22.

a Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University , Jazan , Saudi Arabia.

Quorum sensing (QS) is an inter-cell communication between bacterial populations through release of tiny diffusible compounds as signalling agents, called auto-inducers, abetting bacteria to track population density. QS allows bacterial population to perform collectively in coordination to wide phenotypes like alterations in expression of virulence genes to achieve advancement over their competitors, drug resistance and biofilm formation. Several classes of autoinducers have been described that are involved in bacterial virulence. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1599175DOI Listing

In vitro study of antimicrobial activity on Klebsiella Pneumoniae biofilms in endotracheal tubes.

J Chemother 2019 Apr 16:1-7. Epub 2019 Apr 16.

a Intensive Care Unit, Hospital Universitario y Politécnico La Fe , Valencia , Spain.

Effective treatment approaches for biofilms in endotracheal tubes (ETTs) are lacking. In this study, we evaluated the in vitro effects of five antimicrobials against biofilms formed by Klebsiella pneumoniae in ETTs. K. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1601801DOI Listing
April 2019
1 Read

Effect of short-term carbapenem restriction on the incidence of non-pseudomonal multi-drug resistant Gram-negative bacilli in an intensive care unit.

J Chemother 2019 Apr 14:1-6. Epub 2019 Apr 14.

d Intensive Care Unit , King Saud Medical City , Riyadh , Saudi Arabia.

We conducted a two-phase retrospective study to investigate the impact of a short-term carbapenem restriction on the incidence of non-pseudomonal multidrug-resistant (MDR) Gram-negative bacilli in our intensive care unit (ICU). The first phase of the study (before carbapenem restriction) was conducted between May and July 2016, and the second phase (implementation of carbapenem restriction) between September and November 2016. The incidence of all non-pseudomonal MDR Gram-negative bacilli (extended-spectrum β-lactamase-producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae and MDR Acinetobacter baumannii) decreased significantly after carbapenem restriction. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1601802DOI Listing

GLI inhibitors overcome Erlotinib resistance in human pancreatic cancer cells by modulating E-cadherin.

J Chemother 2019 Apr 14:1-9. Epub 2019 Apr 14.

a Cellular and Molecular Research Center , Yasuj University of Medical Sciences , Yasuj , Iran.

Inhibition of hedgehog (Hh) signalling pathway, including its end effector GLI1, can reverse epithelial-to-mesenchymal transition (EMT) which plays an important role in drug resistance of pancreatic cancer cells to Erlotinib (ETB). This study investigated the effect of GLI inhibitors Forskolin (FSK), GANT-61 (GNT), and Arsenic trioxide (ATX) on suppressing the resistance of pancreatic cancer cells to ETB. The effect of GLI inhibitors was evaluated by measuring mRNA expression levels of EMT factors using quantitative RT-PCR. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2019.1
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http://dx.doi.org/10.1080/1120009X.2019.1584422DOI Listing
April 2019
1 Read

Actual body weight-based vancomycin dosing in neonates.

J Chemother 2019 Apr 14:1-6. Epub 2019 Apr 14.

b Department of Pharmacology , General University Hospital, 1st Faculty of Medicine Charles University in Prague , Czech Republic , Prague , Czech Republic.

This study aimed to explore vancomycin pharmacokinetics and its covariates in critically ill neonates and to propose an easy applicable dosing nomogram for initial treatment. Individual vancomycin pharmacokinetic parameters were calculated based on therapeutic drug monitoring data using a one-compartmental model. A linear regression model was used for examination of covariates. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2019.1
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http://dx.doi.org/10.1080/1120009X.2019.1599574DOI Listing
April 2019
4 Reads

Efficacy of tenofovir and entecavir in patients who relapsed after pegylated interferon therapy.

J Chemother 2019 Apr 9:1-5. Epub 2019 Apr 9.

a Department of Infectious Diseases and Clinical Microbiology , Tepecik Training and Research Hospital , İzmir , Turkey.

Hepatitis B virus (HBV) infections and sequelae present significant health problems worldwide. Two groups of medications are available for chronic HBV infection treatment: (1) interferons (IFNs) and (2) nucleos(t)ide analogues. This study aimed to evaluate entecavir (ETV) and tenofovir disoproxil fumarate (TDF) efficacies in chronic HBV patients, who achieved virological response during Peg-IFN treatment but did not sustain this response and relapsed a year after treatment end. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1597420DOI Listing
April 2019
1 Read

Epidemiology and antifungal susceptibility patterns of candidemia from a tertiary centre in Western Australia.

J Chemother 2019 Apr 7:1-4. Epub 2019 Apr 7.

a Department of Microbiology, PathWest Laboratory Medicine WA , Fiona Stanley Hospital , Murdoch , Australia.

Candidemia is a common invasive fungal infection with a high mortality rate. We performed a retrospective audit of candidemia at a tertiary centre in Western Australia, 2005-2014. There were 167 episodes of candidemia due to 173 isolates of Candida. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1595895DOI Listing
April 2019
1 Read

A retrospective study of tunnelled haemodialysis central line-associated bloodstream infections.

J Chemother 2019 Apr 1:1-5. Epub 2019 Apr 1.

c Departments of Microbiology and Infectious Diseases , PathWest Laboratory Medicine and Fiona Stanley Hospital , Perth , Western Australia , Australia.

Infection is a serious complication of tunnelled haemodialysis catheters. We aimed to describe the epidemiology of tunnelled haemodialysis central line-associated bloodstream infections (CLABSI) in an Australian centre. We performed a retrospective audit of tunnelled haemodialysis CLABSI from June 2010 to June 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2019.1
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http://dx.doi.org/10.1080/1120009X.2019.1595894DOI Listing
April 2019
10 Reads

High prevalence of imipenem-resistant and metallo-beta-lactamase-producing Pseudomonas aeruginosa in the Burns Hospital in Tunisia: detection of a novel class 1 integron.

J Chemother 2019 Mar 8:1-7. Epub 2019 Mar 8.

a Laboratoire des Microorganismes et Biomolécules Actives, Faculté des Sciences de Tunis , Université de Tunis El Manar , Tunis , Tunisia.

Pseudomonas aeruginosa is one of the most important causes of nosocomial infections, and its eradication is very difficult due to its multidrug resistance. The objective of the present study was to characterize the metallo-beta-lactamases (MBLs), integrons, OprD modifications and virulence factors of P. aeruginosa strains isolated from burn patients and to analyze their genetic relatedness by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Read More

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http://dx.doi.org/10.1080/1120009X.2019.1582168DOI Listing
March 2019
1 Read

Distribution of main Gram-positive pathogens causing bloodstream infections in United States and European hospitals during the SENTRY Antimicrobial Surveillance Program (2010-2016): concomitant analysis of oritavancin in vitro activity.

J Chemother 2018 Sep;30(5):280-289

a JMI Laboratories , North Liberty , Iowa , USA.

This study updates the distribution and trends of Gram-positive organisms causing bloodstream infections (BSIs) in the United States (US) and Europe during 2010-2016. In vitro activities of oritavancin and comparators were also evaluated. Staphylococcus aureus, Enterococcus spp. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1516272DOI Listing
September 2018
7 Reads

Assessment of drug-drug interactions between voriconazole and glucocorticoids.

J Chemother 2018 Sep;30(5):296-303

a Pharmaceutical College , Tianjin Medical University , Tianjin , China.

Voriconazole is used to treat fungal infections in patients receiving glucocorticoid therapy in clinic. The objective of this study was to characterize the potential drug-drug interactions (DDIs) between voriconazole and glucocorticoids using physiologically based pharmacokinetic (PBPK) models. Voriconazole and glucocorticoids PBPK models were constructed by using physicochemical data and pharmacokinetic parameters in healthy subjects, and verified by comparing the predicted pharmacokinetic parameters with corresponding data acquired from published literatures. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1506693DOI Listing
September 2018
1 Read

Impact of infectious diseases consultation as a part of an antifungal stewardship programme on candidemia outcome in an Italian tertiary-care, University hospital.

J Chemother 2018 Sep;30(5):304-309

f First Division of Infectious Diseases , Cotugno Hospital, Azienda Ospedaliera dei Colli , Napoli , Italy.

Candidemia is a major cause of in-hospital mortality. Antifungal stewardship programme (AFSP) providing infectious diseases consultation (IDC) might improve the outcome. We evaluate the impact on candidemia mortality of IDC as part of AFSP restricting the use of all antifungals with exception of fluconazole. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1507086DOI Listing
September 2018
1 Read

Scalp infection by Candida Albicans in an immunocompetent patient: a description of a rare case.

J Chemother 2018 Sep;30(5):316-317

a Department of Internal Medicine and Medical Specialties , "Sapienza" University of Rome I School , Italy.

Candida is a large genus of yeast, consisting of about 150 species, among which C.albicans is the most prevalent fungal species of the human microbiota. C. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1518200DOI Listing
September 2018
4 Reads

The use of oral fosfomycin-trometamol in patients with catheter-associated urinary tract infections (CAUTI): new indications for an old antibiotic?

J Chemother 2018 Sep;30(5):290-295

j Department of Health Sciences , University of Florence , Florence , Italy.

We present the results of a multicenter retrospective study of 35 difficult-to-treat patients with urinary tract infections associated with indwelling urinary catheters (CAUTIs). All patients received oral administration of 3 g fosfomycin trometamol once a day for two days and then with a dose of 3 g every 48 h for two weeks. The most commonly isolated strains were: Escherichia coli (65. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1500110DOI Listing
September 2018
3 Reads

Comparison of pharmaceutical quality of eight generic ganciclovir injections in China and Cymevene.

J Chemother 2018 Sep;30(5):310-315

a Department of Pharmaceutics, School of Pharmacy , Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education , Shanghai , PR China.

To assess the pharmaceutical quality of eight commercially available generic products of ganciclovir injection produced in China with original brand product (Cymevene, Roche, Switzerland). Tests were performed according to China Pharmacopoeia 2015 and Import Drug Registration Standard introduced by CFDA. Items including characteristics of the packing and reconstituted solution, pH, visible particles, content of active and related substances, sterility and bacterial endotoxin were all carried out based on the standard laboratory operating rules and requirements. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1516271DOI Listing
September 2018

A case report of a TDM-guided optimization of mitotane for a safe and effective long-term treatment.

J Chemother 2019 Apr 4;31(2):105-108. Epub 2019 Mar 4.

a Department of Clinical and Experimental Medicine , University of Pisa , Pisa , Italy.

A 43-years old woman was diagnosed an adrenocortical carcinoma (AC) that was excised, whereas two lung metastases were un-operable. Mitotane 6 g/day was started as standard therapy but it was responsible for severe central nervous system (CNS) and gastrointestinal toxicities associated with a 10 kg body weight loss. A therapeutic drug monitoring (TDM) protocol demonstrated that mitotane plasma concentrations (>30 mg/L) exceeded the therapeutic range (14-20 mg/L) and increased even when drug daily dose was reduced by 50%. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1552502DOI Listing
April 2019
3 Reads

Combination of Coral UTI Screen system, gram-stain and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for diagnosis of urinary tract infections directly from urine samples.

J Chemother 2019 Apr 20;31(2):74-80. Epub 2019 Feb 20.

a UGC Microbiology , Reina Sofía University Hospital , Córdoba , Spain.

This study proposes an algorithm for microbiological diagnosis of urinary tract infections based on screening by luminometry and Gram-stain, followed by identification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Positive urine samples detected with the luminometry screening Coral UTI Screen system underwent Gram staining and identification of the causative organism was performed by MALDI-TOF Microflex LT mass spectrometer (Bruker Daltonics, Germany). Subsequently, the results were compared with those of conventional culture identification using WIDER MIC/id system (Francisco Soria Melguizo SA, Spain). Read More

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http://dx.doi.org/10.1080/1120009X.2019.1573284DOI Listing
April 2019
1 Read

Dynamics and management of oral anticoagulant treatment in chronic hepatitis C patients undergoing therapy with direct antiviral agents.

J Chemother 2019 Apr 20;31(2):86-89. Epub 2019 Feb 20.

a Department of Internal Medicine , University of Campania 'L. Vanvitelli ', Caserta CE, Italy.

Current regimens of direct-acting antiviral agents (DAA) are effective and safe for chronic hepatitis C (CHC). However, DAA often interfere with concomitant medications. We treated seven CHC patients with DAA who were on chronic anticoagulant treatment with warfarin, and describe the dynamics of prothrombin time, providing novel data, useful for the clinician. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1571661DOI Listing
April 2019
3 Reads

Antibiotic and Anticoagulation Therapy in Lemierre's Syndrome: Case Report and Review.

J Chemother 2019 Feb;31(1):42-48

a Department of Sensory Organs , University ''Sapienza'' of Rome , Rome, Italy.

Lemierre's syndrome is a rare and fatal disease and is also known as the forgotten disease to describe the rarity of this syndrome in the antibiotic era. However, in the last 20 years, the incidence of this disease has been increasing. Authors report a case of Lemierre's syndrome with extensive venous thrombosis involving right internal jugular veins with extension to the sigmoid and lateral sinus and also review the literature on the use of anticoagulant therapy in Lemierre's syndrome. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1554992DOI Listing
February 2019
1 Read

Long-Term Evaluation of Combination Treatment of Single Agent HD-MTX Chemotherapy up to Three Cycles and Moderate Dose Whole Brain Irradiation for Primary CNS Lymphoma.

J Chemother 2019 Feb;31(1):35-41

b Department of Radiation Medicine , Hokkaido University Faculty of Medicine , Sapporo , Japan.

High-dose methotrexate (HD-MTX)-based chemotherapy in combination with whole brain radiotherapy (WBRT) has been a common therapy for primary central nervous system lymphoma (PCNSL). The aim of this study was to evaluate the survival benefit of a minimized cycle of HD-MTX monotherapy prior to WBRT. A maximum of three cycles of HD-MTX was combined with a WBRT dose of 30 Gy and an additional localized boost was administered where remnant was observed. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1546984DOI Listing
February 2019
5 Reads

Elastin-Like Polypeptide Delivers a Notch Inhibitory Peptide to Inhibit Tumor Growth in Combination with Paclitaxel.

J Chemother 2019 Feb;31(1):23-29

a Department of Biochemistry , University of Mississippi Medical Center , Jackson , Mississippi , USA .

This research describes a thermally responsive elastin-like polypeptide (ELP) for the delivery of dnMAML peptides that inhibit the Notch pathway. Exploiting passive targeting and a thermally active tumor-targeting technique available through the use of ELP, the dnMAML peptide was efficiently delivered to tumor tissue. Furthermore, this ELP-dnMAML was modified with the addition of a cell penetrating peptide (SynB1) for improved infiltration of ELP-dnMAML into the tumor cells. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1537554DOI Listing
February 2019

Calcium Channel Blockers Possibly Delay the Elimination of Plasma Methotrexate in Patients Receiving High-Dose Methotrexate Therapy.

J Chemother 2019 Feb;31(1):30-34

a Department of Pharmacy , Osaka City University Hospital , Osaka , Japan.

Delayed elimination of plasma methotrexate (MTX), which leads to elevated toxicity, is often observed in patients receiving high-dose methotrexate (HD-MTX) therapy, despite of the preventive measures. In this study, we investigated the factors that delay elimination of plasma MTX in patients on HD-MTX therapy. Fifteen patients who received HD-MTX therapy (21 cycles) were classified into two groups: delayed elimination of plasma MTX (38. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1544194DOI Listing
February 2019
1 Read

Invasive fungal infection in crtically ill patients: hurdles and next challenges.

J Chemother 2019 Apr 14;31(2):64-73. Epub 2019 Feb 14.

g Intensive Care Unit , Hospital Universitario Dr. Peset , Valencia , Spain.

A narrative review from a multidisciplinary task force of experts in critical care medicine and clinical mycology was carried out. The multi drug-resistant species Candida auris has emerged simultaneously on several continents, causing hospital outbreaks, especially in critically ill patients. Although there are not enough data to support the routine use of continuous antibiotic prophylaxis in patients subjected to extracorporeal membrane oxygenator, a clear increase of invasive fungal infection (IFI) has been described with the use of this device. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1557799DOI Listing
April 2019
7 Reads

Severe toxicity in adult patients with lung cancer under treatment with pemetrexed: a prospective cohort study.

J Chemother 2019 Apr 10;31(2):95-104. Epub 2019 Feb 10.

a Clinical Pharmacology Section, Internal Medicine Department , Hospital Italiano de Buenos Aires, Buenos Aires , Argentina.

Pemetrexed is an antimetabolite approved for treatment of non-small cell lung cancer. Harbouring interindividual variability in both the pharmacokinetic and pharmacogenetic profiles may lead to life-threatening toxicities. A prospective cohort study of adult patients initiating treatment with pemetrexed in combination with platinum between 2013 and 2015 were follow up. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1572287DOI Listing
April 2019
2 Reads

Short-term adverse effects of anticancer drugs in patients with type 2 diabetes.

J Chemother 2019 Feb 10:1-10. Epub 2019 Feb 10.

a Department of Clinical and Experimental Medicine , Endocrinology Section, University of Catania Medical School , Garibaldi-Nesima Hospital , Catania , Italy.

The short-term adverse effects of anticancer drugs (AD) in patients with type 2 diabetes (T2D) are poorly studied and their management still represents an important challenge for clinicians. We carried out a retrospective single-center study in 168 patients with T2D and cancer, evaluating both the short-term effects of first-line AD on glycemic control and chronic diabetes complications. Average glycated hemoglobin significantly increased after AD compared to values before treatment (7. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1572297DOI Listing
February 2019

Antimicrobial treatment of Kocuria kristinae invasive infections: Systematic review.

J Chemother 2019 Jan 28:1-11. Epub 2019 Jan 28.

a Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia.

Objective of this systematic review was to establish whether and what invasive infections in humans were caused by Kocuria kristinae, and to evaluate outcomes of administered antibiotic treatment. MEDLINE, EBSCO, SCOPUS, SCINDEKS and GOOGLE SCHOLAR were systematically searched for primary case reports or case series describing invasive infections with K. kristinae. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1542551DOI Listing
January 2019
6 Reads

Broad spectrum antibiotics in newborns increase multi-drug resistant infections.

J Chemother 2019 Apr 24;31(2):81-85. Epub 2019 Jan 24.

a Neonatal Intensive Care Unit . Puerta del Mar University Hospital , Cádiz . Spain.

Our objective was to determine if broad spectrum antibiotics (BSA) are associated with multi-resistant bacterial (MRB) infections in neonatal patients. We conducted a case-control study with two groups of patients: those with and without a MRB infection. We included 43 cases and 43 controls. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1556832DOI Listing
April 2019
1 Read

In-vitro activities of imipenem-colistin, imipenem-tigecycline, and tigecycline-colistin combinations against carbapenem-resistant Enterobacteriaceae.

J Chemother 2018 Oct - Dec;30(6-8):342-347

d Department of Molecular Biology and Genetics , Istanbul Technical University , Turkey.

The aim of the study is to determine in-vitro effects of imipenem-tigecycline, imipenem-colistin and tigecycline-colistin against carbapenem-resistant Enterobacteriaceae (CRE) isolates. A total of 25 CRE isolates were included to the study. The minimum inhibition concentrations of imipenem, colistin-sulphate and tigecycline were determined with broth dilution method. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1516270DOI Listing
January 2019
3 Reads

Common microbial causes of significant bacteriuria and their antibiotic resistance pattern in the Isfahan Province of Iran.

J Chemother 2018 Oct - Dec;30(6-8):348-353

c Department of Pathology , Medical School, Isfahan University of Medical Sciences , Isfahan , Iran.

Urinary tract infections (UTIs) are considered the most common community-acquired infections worldwide, which have possible complications along with significant economic impact on national healthcare systems. The aim of this study was to identify the most common causes of significant bacteriuria and to assess their antimicrobial resistance pattern in the Isfahan province of Iran. In this cross-sectional study, 11,678 urine samples of the patients referred to Mahdieh Medical Diagnostic Centre Charity were examined over a period of 10 months (from September 2015 to June 2016). Read More

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http://dx.doi.org/10.1080/1120009X.2018.1525120DOI Listing
January 2019
1 Read

Comparative in vitro antimicrobial activities of CSA-142 and CSA-192, second-generation ceragenins, with CSA-13 against various microorganisms.

J Chemother 2018 Oct - Dec;30(6-8):332-337

b Department of Chemistry and Biochemistry , Brigham Young University , Provo , UT , USA.

Ceragenins, a novel family of antibiotics, are cationic derivatives of cholic acid and display broad-spectrum antimicrobial activities. Multiple ceragenins have been synthesized and studied, and most published data are with ceragenin CSA-13. This study aimed to investigate the in vitro antimicrobial properties of second-generation ceragenins, CSA-142 and CSA-192, and compare them to CSA-13. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1534567DOI Listing
January 2019
1 Read

Relationship between antibiotic resistance, efflux pumps, and biofilm formation in extended-spectrum β-lactamase producing Klebsiella pneumoniae.

J Chemother 2018 Oct - Dec;30(6-8):354-363

d Microbiology Laboratory , Education and Research Hospital , Samsun , Turkey.

Klebsiella pneumoniae is an important pathogen both in community and hospital environment. In this study, we aimed to determine the antibiotic susceptibilities, expression levels of AcrA, ketM, kdeA, kpnEF, and kexD genes related to efflux pump and biofilm formation in 100 extended-spectrum β-lactamase producing Klebsiella pneumoniae. The relative expression levels of AcrA, ketM, kdeA, kpnEF, and kexD were determined by quantitative real-time PCR and biofilm formation was screened by microtiter plate assay. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1521773DOI Listing
January 2019
3 Reads

Concentration-dependent enrichment of resistant Enterococcus faecium exposed to linezolid in an in vitro dynamic model.

J Chemother 2018 Oct - Dec;30(6-8):364-370

a Department of Pharmacokinetics and Pharmacodynamics , Gause Institute of New Antibiotics , Moscow , Russia.

To explore the relationship between pharmacokinetic variables and enterococcal resistance to linezolid, a vancomycin-resistant strain whose mutant prevention concentration (MPC) exceeded the MIC by two fold was selected among six clinical isolates of Enterococcus faecium. The selected strain was exposed to simulated pharmacokinetics of twice-daily linezolid for five days. Mutants resistant to 2 × MIC of the antibiotic were enriched at ratios of the 24-h area under the concentration-time curve (AUC) to the MIC of 15 and 30 h but not at 60 and 120 h. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1533267DOI Listing
January 2019
1 Read

Fatigue with epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients: A meta-analysis of randomized controlled trials.

Authors:
Jing Li Wenxia Sun

J Chemother 2018 Oct - Dec;30(6-8):323-331

b Chengdu Univeisity, Sichuan Industrial Institute of Antibiotics , Longtan Industrial Park , Chengdu , Sichuan , People's Republic of China.

We conducted this systematic review to fully investigate the fatigue of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in cancer patients. The approved and clinical used EGFR-TKIs were selected for the present meta-analysis. The relevant studies of the randomized controlled trials (RCTs) in cancer patients treated with EGFR-TKIs were retrieved and the systematic evaluation was conducted. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1516269DOI Listing
January 2019
2 Reads

Stability of 90 mg/mL cefuroxime sodium solution for administration by continuous infusion.

J Chemother 2018 Oct - Dec;30(6-8):371-374

a Department of Clinical Pharmacy , University Hospital of Liège , Liège , Belgium.

Continuous infusions of β-lactam antibiotics increase pharmacokinetic/pharmacodynamic target attainment. However, this way of administration brings about some practical issues such as stability. This study aims to determine the stability of a 90 mg/mL cefuroxime sodium solution. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1535950DOI Listing
January 2019
2 Reads

Treatment outcomes of adult Burkitt lymphoma: results with a modified LMB protocol in Brazil and feasibility of outpatient administration.

J Chemother 2018 Oct - Dec;30(6-8):375-379

a Department of Hematology , Institute of Cancer of São Paulo (ICESP), University of São Paulo , São Paulo , Brazil.

While Burkitt lymphoma (BL) is an aggressive subtype of non-Hodgkin lymphoma more prevalent in tropical areas, few studies on BL have been conducted in Latin America. Here, we evaluate the clinical presentation and outcomes of an adapted LMB regimen for adults with sporadic BL. We retrospectively evaluated hospital records from University of São Paulo (USP) between 1999 and 2017. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1535771DOI Listing
January 2019
3 Reads

Acute kidney injury: an unusual complication of posaconazole use.

J Chemother 2018 Oct - Dec;30(6-8):380-383

b The National Aspergillosis Centre, 2nd Floor Education and Research Centre , Manchester University NHS Foundation Trust , Manchester , UK.

Triazole antifungals are useful in the treatment of Aspergillus disease and these drugs have side effects which clinicians should be aware of. Posaconazole is an orally administered second-generation triazole antifungal agent which inhibits lanosterol 14-alpha-demethylase, an enzyme that converts lanosterol to ergosterol, a vital component of the fungal cell membrane. Posaconazole has a favorable side effect profile, is safe and well tolerated when compared to the earlier generation of triazole antifungals. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1522472DOI Listing
January 2019
2 Reads

Virulence of MRSA USA300 is enhanced by sub-inhibitory concentration of two different classes of antibiotics.

J Chemother 2018 Oct - Dec;30(6-8):384-388

a Department of Public Health and Infectious Diseases , Sapienza University , Rome , Italy.

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 is responsible of many kinds of infections of skin and soft-tissue. Antibiotic resistance, biofilm formation and the ability to adhere and invade are virulence factors that contribute to MRSA pathogenesis. In some cases, decreased bioavailability of antibiotics in systemic circulation could result; in these conditions sub-therapeutic levels of the antibiotics may be established, exposing bacteria to sub-inhibitory concentrations. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1533085DOI Listing
January 2019
2 Reads

First report of polymyxin B activity in Klebsiella pneumoniae biofilm.

J Chemother 2019 Jan 19:1-5. Epub 2019 Jan 19.

a Laboratório de Microbiologia Médica, Universidade Federal de São João del-Rei (UFSJ) , Campus Centro Oeste Dona Lindu , Divinópolis , Minas Gerais , Brazil.

Considering the clinical importance of biofilm in medical devices and chronic infections, this study aimed to investigate the action of polymyxin B on Klebsiella pneumoniae (K. pneumoniae) biofilm. The experiments were performed using a biofilm formation assay and the interaction of polysorbate 80 was explored. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1558751DOI Listing
January 2019
11 Reads

Microbiota and cancer: an update.

J Chemother 2019 Apr 16;31(2):59-63. Epub 2019 Jan 16.

b First Department of Pedicatrics, Hematology and Oncology , University of Athens , Athens , Greece.

The number of microbes in the human intestine is approximately 1 × 10, while the number of eukaryotic cells in the human body is around 1 × 10. As a result of co-evolution of the host mucosal immune system and the microbiota, both have developed multiple mechanisms to maintain homeostasis. Nevertheless, when these mechanisms are disturbed by pathogenic bacteria, which invade this fragile environment, the immune system responds to the microbiota and may support tumour growth in the intestine. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1541046DOI Listing
April 2019
16 Reads

Carbapenem-Resistant Klebsiella Pneumoniae in Iran: a Systematic Review and Meta-Analysis.

J Chemother 2019 Feb 30;31(1):1-8. Epub 2018 Dec 30.

e Department of Microbiology , School of Medicine, Ardabil University of Medical Sciences , Ardabil , Iran.

The global emergence and dissemination of carbapenem-resistant (CR)-Klebsiella pneumoniae is an important healthcare concern owing to the limited therapeutic options that are available. The aim of the present study was to evaluate the prevalence of CR K. pneumoniae in different parts of Iran. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1533266DOI Listing
February 2019
2 Reads
1.073 Impact Factor

Efficacy and safety of nivolumab in patients with non-small cell lung cancer: a retrospective study in clinical practice.

J Chemother 2019 Apr 30;31(2):90-94. Epub 2018 Dec 30.

c Oncologie multidisciplinaire et innovations thérapeutiques , AP-HM , Marseille , France.

Nivolumab, a fully human immunoglobulin monoclonal antibody inhibiting the programmed cell death protein-1 receptor, demonstrated robust efficacy and a manageable safety profile across multiple tumor types in clinical trials. The aim of the present study was to investigate the efficacy and safety of nivolumab for pretreated patients with non-small cell lung cancers in clinical practice. In this observational monocentric retrospective study, 98 patients were enrolled between February 2015 and February 2016. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1551753DOI Listing
April 2019
2 Reads

An Observational Study of the Efficacy and Safety of Voriconazole in a Real-Life Clinical Setting.

J Chemother 2019 Feb 22;31(1):49-57. Epub 2018 Dec 22.

a Department of Pharmacy , University Clinical Hospital Santiago de Compostela (SERGAS) , Santiago de Compostela , Spain.

An observational retrospective study in patients treated with voriconazole was made to evaluate outcomes, safety, drug interactions and characteristics of the treatment. A total of 96 patients were included. In 78. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1524085DOI Listing
February 2019
2 Reads

Epidemiology and Microbiology of Skin and Soft Tissue Infections: Preliminary Results of a National Registry.

J Chemother 2019 Feb 3;31(1):9-14. Epub 2018 Dec 3.

y UOC Medicina Interna , Ospedale Umberto I , Enna , Italy.

Skin and soft tissue infections (SSTIs) represent a wide range of clinical conditions characterized by a considerable variety of clinical presentations and severity. Their aetiology can also vary, with numerous possible causative pathogens. While other authors previously published analyses on several types of SSTI and on restricted types of patients, we conducted a large nationwide surveillance programme on behalf of the Italian Society of Infectious and Tropical Diseases to assess the clinical and microbiological characteristics of the whole SSTI spectrum, from mild to severe life-threatening infections, in both inpatients and outpatients. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1536320DOI Listing
February 2019
8 Reads
1.073 Impact Factor

Transurethral Resection of the Prostate: are We Following the Guidelines? - Outcomes from the Global Prevalence of Infections in Urology (GPIU) Study.

J Chemother 2019 Feb 3;31(1):15-22. Epub 2018 Dec 3.

k Department of Urology, Paediatric Urology and Andrology , Justus-Liebig-University , Gießen , Germany.

Transurethral resection of the prostate (TURP) is one of the most common urological procedures. With the increasing rate of multiresistant infections including urosepsis, it is essential for all surgeons to adhere to the relevant international guidelines to prevent infectious complications. The aim of this prospective, multinational, multicentre study was to evaluate compliance with recommended infection control measures regarding TURP procedures. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1542552DOI Listing
February 2019
26 Reads

A phase II study: dose-dense carboplatin and paclitaxel as neoadjuvant chemotherapy in locally advanced cervical cancer.

J Chemother 2018 Jul;30(4):247-252

a Gynecologic Oncology Unit, Department of Biomedical Science and Human Oncology , University of Bari , Bari , Italy.

This study evaluates the efficacy and toxicity of dose-dense weekly paclitaxel and carboplatin as neoadjuvant chemotherapy in locally advanced cervical cancer (LACC). We collected 23 cases of LACC treated with weekly paclitaxel and carboplatin for nine cycles: 20 patients had complete or partial response to chemotherapy and were submitted to surgery, 3 with poor response received chemoradiation therapy. Pathologic examination showed complete response in four patients, myometrial invasion <50% in nine and >50% in seven patients, parametrial involvement in two, vaginal metastasis in one and lymphovascular space invasion, with positive margins, in another case. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1489601DOI Listing
July 2018
20 Reads

Prediction of the effect of voriconazole on the pharmacokinetics of non-steroidal anti-inflammatory drugs.

J Chemother 2018 Jul;30(4):240-246

c Department of Pharmacology , Tianjin Medical University , Tianjin , China.

To evaluate the impact of voriconazole on the pharmacokinetics of Non-steroidal anti-inflammatory drugs (NSAIDs). Pharmacokinetic and physiochemical properties of voriconazole and NSAIDs are applied to build physiologically based pharmacokinetic (PBPK) models using Gastroplus. The PBPK models of voriconazole and NSAIDs are verified by published studies, respectively. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1500197DOI Listing
July 2018
3 Reads

In vitro activity of ceftaroline and ceftobiprole against methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin isolated in paediatric patients.

J Chemother 2018 Oct - Dec;30(6-8):338-341. Epub 2018 Oct 30.

a Clinical Pathology Laboratory and Microbiology Unit , IRCCS Istituto Giannina Gaslini, Children's Hospital , Genova , Italy.

Minimal inhibitory concentrations (MIC, mg/l) of ceftaroline and ceftobiprole were evaluated over 70 methicillin-resistant Staphylococcus aureus (MRSA) strains with vancomycin MIC ≥1 isolated in a paediatric hospital. The proportion of non-wild-type strains (MIC > epidemiological cut off) was 18% for ceftobiprole and 64% for ceftaroline. Only 1. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1522473DOI Listing
October 2018
19 Reads

Pulmonary adverse events related to idelalisib therapy: A single centre experience.

J Chemother 2018 Sep 9;30(5):318-322. Epub 2018 Oct 9.

a CHU Reims, Service de Médecine Interne et Maladies Infectieuses et Tropicales , Reims , France.

Idelalisib is a potent and selective inhibitor of the PI3Kδ approved since September 2014 for the treatment of several types of B cell malignancies. Pulmonary adverse events related to idelalisib are an emerging serious adverse event. We report here a single centre cohort of 16 patients who initiated idelalisib as routine treatment. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1516184DOI Listing
September 2018
15 Reads
1.073 Impact Factor

Poor in vivo efficacy of caspofungin, micafungin and amphotericin B against wild-type Candida krusei clinical isolates does not correlate with in vitro susceptibility results.

J Chemother 2018 Jul 20;30(4):233-239. Epub 2018 Jul 20.

b Faculty of Medicine, Department of Medical Microbiology , University of Debrecen , Debrecen , Hungary.

We determined micafungin, caspofungin and amphotericin B (AMB) minimum inhibitory concentration (MICs) and killing rates in RPMI-1640 and in RPMI-1640 with 50% serum against three Candida krusei bloodstream isolates. MIC ranges in RPMI-1640 were 0.125-0. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1487150DOI Listing
July 2018
2 Reads