3,779 results match your criteria Journal of Chemotherapy[Journal]


Combination of Coral UTI Screen system, gram-stain and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for diagnosis of urinary tract infections directly from urine samples.

J Chemother 2019 Feb 20:1-7. Epub 2019 Feb 20.

a UGC Microbiology , Reina Sofía University Hospital , Córdoba , Spain.

This study proposes an algorithm for microbiological diagnosis of urinary tract infections based on screening by luminometry and Gram-stain, followed by identification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Positive urine samples detected with the luminometry screening Coral UTI Screen system underwent Gram staining and identification of the causative organism was performed by MALDI-TOF Microflex LT mass spectrometer (Bruker Daltonics, Germany). Subsequently, the results were compared with those of conventional culture identification using WIDER MIC/id system (Francisco Soria Melguizo SA, Spain). Read More

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http://dx.doi.org/10.1080/1120009X.2019.1573284DOI Listing
February 2019

Dynamics and management of oral anticoagulant treatment in chronic hepatitis C patients undergoing therapy with direct antiviral agents.

J Chemother 2019 Feb 20:1-4. Epub 2019 Feb 20.

a Department of Internal Medicine , University of Campania 'L. Vanvitelli ', Caserta CE, Italy.

Current regimens of direct-acting antiviral agents (DAA) are effective and safe for chronic hepatitis C (CHC). However, DAA often interfere with concomitant medications. We treated seven CHC patients with DAA who were on chronic anticoagulant treatment with warfarin, and describe the dynamics of prothrombin time, providing novel data, useful for the clinician. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1571661DOI Listing
February 2019

Antibiotic and Anticoagulation Therapy in Lemierre's Syndrome: Case Report and Review.

J Chemother 2019 Feb;31(1):42-48

a Department of Sensory Organs , University ''Sapienza'' of Rome , Rome, Italy.

Lemierre's syndrome is a rare and fatal disease and is also known as the forgotten disease to describe the rarity of this syndrome in the antibiotic era. However, in the last 20 years, the incidence of this disease has been increasing. Authors report a case of Lemierre's syndrome with extensive venous thrombosis involving right internal jugular veins with extension to the sigmoid and lateral sinus and also review the literature on the use of anticoagulant therapy in Lemierre's syndrome. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1554992DOI Listing
February 2019

Long-Term Evaluation of Combination Treatment of Single Agent HD-MTX Chemotherapy up to Three Cycles and Moderate Dose Whole Brain Irradiation for Primary CNS Lymphoma.

J Chemother 2019 Feb;31(1):35-41

b Department of Radiation Medicine , Hokkaido University Faculty of Medicine , Sapporo , Japan.

High-dose methotrexate (HD-MTX)-based chemotherapy in combination with whole brain radiotherapy (WBRT) has been a common therapy for primary central nervous system lymphoma (PCNSL). The aim of this study was to evaluate the survival benefit of a minimized cycle of HD-MTX monotherapy prior to WBRT. A maximum of three cycles of HD-MTX was combined with a WBRT dose of 30 Gy and an additional localized boost was administered where remnant was observed. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1546984DOI Listing
February 2019

Elastin-Like Polypeptide Delivers a Notch Inhibitory Peptide to Inhibit Tumor Growth in Combination with Paclitaxel.

J Chemother 2019 Feb;31(1):23-29

a Department of Biochemistry , University of Mississippi Medical Center , Jackson , Mississippi , USA .

This research describes a thermally responsive elastin-like polypeptide (ELP) for the delivery of dnMAML peptides that inhibit the Notch pathway. Exploiting passive targeting and a thermally active tumor-targeting technique available through the use of ELP, the dnMAML peptide was efficiently delivered to tumor tissue. Furthermore, this ELP-dnMAML was modified with the addition of a cell penetrating peptide (SynB1) for improved infiltration of ELP-dnMAML into the tumor cells. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1537554DOI Listing
February 2019

Calcium Channel Blockers Possibly Delay the Elimination of Plasma Methotrexate in Patients Receiving High-Dose Methotrexate Therapy.

J Chemother 2019 Feb;31(1):30-34

a Department of Pharmacy , Osaka City University Hospital , Osaka , Japan.

Delayed elimination of plasma methotrexate (MTX), which leads to elevated toxicity, is often observed in patients receiving high-dose methotrexate (HD-MTX) therapy, despite of the preventive measures. In this study, we investigated the factors that delay elimination of plasma MTX in patients on HD-MTX therapy. Fifteen patients who received HD-MTX therapy (21 cycles) were classified into two groups: delayed elimination of plasma MTX (38. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1544194DOI Listing
February 2019

Invasive fungal infection in crtically ill patients: hurdles and next challenges.

J Chemother 2019 Feb 14:1-10. Epub 2019 Feb 14.

g Intensive Care Unit , Hospital Universitario Dr. Peset , Valencia , Spain.

A narrative review from a multidisciplinary task force of experts in critical care medicine and clinical mycology was carried out. The multi drug-resistant species Candida auris has emerged simultaneously on several continents, causing hospital outbreaks, especially in critically ill patients. Although there are not enough data to support the routine use of continuous antibiotic prophylaxis in patients subjected to extracorporeal membrane oxygenator, a clear increase of invasive fungal infection (IFI) has been described with the use of this device. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1557799DOI Listing
February 2019
3 Reads

Severe toxicity in adult patients with lung cancer under treatment with pemetrexed: a prospective cohort study.

J Chemother 2019 Feb 10:1-10. Epub 2019 Feb 10.

a Clinical Pharmacology Section, Internal Medicine Department , Hospital Italiano de Buenos Aires, Buenos Aires , Argentina.

Pemetrexed is an antimetabolite approved for treatment of non-small cell lung cancer. Harbouring interindividual variability in both the pharmacokinetic and pharmacogenetic profiles may lead to life-threatening toxicities. A prospective cohort study of adult patients initiating treatment with pemetrexed in combination with platinum between 2013 and 2015 were follow up. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1572287DOI Listing
February 2019
1 Read

Short-term adverse effects of anticancer drugs in patients with type 2 diabetes.

J Chemother 2019 Feb 10:1-10. Epub 2019 Feb 10.

a Department of Clinical and Experimental Medicine , Endocrinology Section, University of Catania Medical School , Garibaldi-Nesima Hospital , Catania , Italy.

The short-term adverse effects of anticancer drugs (AD) in patients with type 2 diabetes (T2D) are poorly studied and their management still represents an important challenge for clinicians. We carried out a retrospective single-center study in 168 patients with T2D and cancer, evaluating both the short-term effects of first-line AD on glycemic control and chronic diabetes complications. Average glycated hemoglobin significantly increased after AD compared to values before treatment (7. Read More

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http://dx.doi.org/10.1080/1120009X.2019.1572297DOI Listing
February 2019

Antimicrobial treatment of Kocuria kristinae invasive infections: Systematic review.

J Chemother 2019 Jan 28:1-11. Epub 2019 Jan 28.

a Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia.

Objective of this systematic review was to establish whether and what invasive infections in humans were caused by Kocuria kristinae, and to evaluate outcomes of administered antibiotic treatment. MEDLINE, EBSCO, SCOPUS, SCINDEKS and GOOGLE SCHOLAR were systematically searched for primary case reports or case series describing invasive infections with K. kristinae. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1542551DOI Listing
January 2019

Broad spectrum antibiotics in newborns increase multi-drug resistant infections.

J Chemother 2019 Jan 24:1-5. Epub 2019 Jan 24.

a Neonatal Intensive Care Unit . Puerta del Mar University Hospital , Cádiz . Spain.

Our objective was to determine if broad spectrum antibiotics (BSA) are associated with multi-resistant bacterial (MRB) infections in neonatal patients. We conducted a case-control study with two groups of patients: those with and without a MRB infection. We included 43 cases and 43 controls. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1556832DOI Listing
January 2019

In-vitro activities of imipenem-colistin, imipenem-tigecycline, and tigecycline-colistin combinations against carbapenem-resistant Enterobacteriaceae.

J Chemother 2018 Oct - Dec;30(6-8):342-347

d Department of Molecular Biology and Genetics , Istanbul Technical University , Turkey.

The aim of the study is to determine in-vitro effects of imipenem-tigecycline, imipenem-colistin and tigecycline-colistin against carbapenem-resistant Enterobacteriaceae (CRE) isolates. A total of 25 CRE isolates were included to the study. The minimum inhibition concentrations of imipenem, colistin-sulphate and tigecycline were determined with broth dilution method. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1516270DOI Listing
January 2019

Common microbial causes of significant bacteriuria and their antibiotic resistance pattern in the Isfahan Province of Iran.

J Chemother 2018 Oct - Dec;30(6-8):348-353

c Department of Pathology , Medical School, Isfahan University of Medical Sciences , Isfahan , Iran.

Urinary tract infections (UTIs) are considered the most common community-acquired infections worldwide, which have possible complications along with significant economic impact on national healthcare systems. The aim of this study was to identify the most common causes of significant bacteriuria and to assess their antimicrobial resistance pattern in the Isfahan province of Iran. In this cross-sectional study, 11,678 urine samples of the patients referred to Mahdieh Medical Diagnostic Centre Charity were examined over a period of 10 months (from September 2015 to June 2016). Read More

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http://dx.doi.org/10.1080/1120009X.2018.1525120DOI Listing
January 2019
1 Read

Comparative in vitro antimicrobial activities of CSA-142 and CSA-192, second-generation ceragenins, with CSA-13 against various microorganisms.

J Chemother 2018 Oct - Dec;30(6-8):332-337

b Department of Chemistry and Biochemistry , Brigham Young University , Provo , UT , USA.

Ceragenins, a novel family of antibiotics, are cationic derivatives of cholic acid and display broad-spectrum antimicrobial activities. Multiple ceragenins have been synthesized and studied, and most published data are with ceragenin CSA-13. This study aimed to investigate the in vitro antimicrobial properties of second-generation ceragenins, CSA-142 and CSA-192, and compare them to CSA-13. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1534567DOI Listing
January 2019
1 Read

Relationship between antibiotic resistance, efflux pumps, and biofilm formation in extended-spectrum β-lactamase producing Klebsiella pneumoniae.

J Chemother 2018 Oct - Dec;30(6-8):354-363

d Microbiology Laboratory , Education and Research Hospital , Samsun , Turkey.

Klebsiella pneumoniae is an important pathogen both in community and hospital environment. In this study, we aimed to determine the antibiotic susceptibilities, expression levels of AcrA, ketM, kdeA, kpnEF, and kexD genes related to efflux pump and biofilm formation in 100 extended-spectrum β-lactamase producing Klebsiella pneumoniae. The relative expression levels of AcrA, ketM, kdeA, kpnEF, and kexD were determined by quantitative real-time PCR and biofilm formation was screened by microtiter plate assay. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1521773DOI Listing
January 2019

Concentration-dependent enrichment of resistant Enterococcus faecium exposed to linezolid in an in vitro dynamic model.

J Chemother 2018 Oct - Dec;30(6-8):364-370

a Department of Pharmacokinetics and Pharmacodynamics , Gause Institute of New Antibiotics , Moscow , Russia.

To explore the relationship between pharmacokinetic variables and enterococcal resistance to linezolid, a vancomycin-resistant strain whose mutant prevention concentration (MPC) exceeded the MIC by two fold was selected among six clinical isolates of Enterococcus faecium. The selected strain was exposed to simulated pharmacokinetics of twice-daily linezolid for five days. Mutants resistant to 2 × MIC of the antibiotic were enriched at ratios of the 24-h area under the concentration-time curve (AUC) to the MIC of 15 and 30 h but not at 60 and 120 h. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1533267DOI Listing
January 2019

Fatigue with epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients: A meta-analysis of randomized controlled trials.

Authors:
Jing Li Wenxia Sun

J Chemother 2018 Oct - Dec;30(6-8):323-331

b Chengdu Univeisity, Sichuan Industrial Institute of Antibiotics , Longtan Industrial Park , Chengdu , Sichuan , People's Republic of China.

We conducted this systematic review to fully investigate the fatigue of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in cancer patients. The approved and clinical used EGFR-TKIs were selected for the present meta-analysis. The relevant studies of the randomized controlled trials (RCTs) in cancer patients treated with EGFR-TKIs were retrieved and the systematic evaluation was conducted. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1516269DOI Listing
January 2019

Stability of 90 mg/mL cefuroxime sodium solution for administration by continuous infusion.

J Chemother 2018 Oct - Dec;30(6-8):371-374

a Department of Clinical Pharmacy , University Hospital of Liège , Liège , Belgium.

Continuous infusions of β-lactam antibiotics increase pharmacokinetic/pharmacodynamic target attainment. However, this way of administration brings about some practical issues such as stability. This study aims to determine the stability of a 90 mg/mL cefuroxime sodium solution. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1535950DOI Listing
January 2019
1 Read

Treatment outcomes of adult Burkitt lymphoma: results with a modified LMB protocol in Brazil and feasibility of outpatient administration.

J Chemother 2018 Oct - Dec;30(6-8):375-379

a Department of Hematology , Institute of Cancer of São Paulo (ICESP), University of São Paulo , São Paulo , Brazil.

While Burkitt lymphoma (BL) is an aggressive subtype of non-Hodgkin lymphoma more prevalent in tropical areas, few studies on BL have been conducted in Latin America. Here, we evaluate the clinical presentation and outcomes of an adapted LMB regimen for adults with sporadic BL. We retrospectively evaluated hospital records from University of São Paulo (USP) between 1999 and 2017. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1535771DOI Listing
January 2019
2 Reads

Acute kidney injury: an unusual complication of posaconazole use.

J Chemother 2018 Oct - Dec;30(6-8):380-383

b The National Aspergillosis Centre, 2nd Floor Education and Research Centre , Manchester University NHS Foundation Trust , Manchester , UK.

Triazole antifungals are useful in the treatment of Aspergillus disease and these drugs have side effects which clinicians should be aware of. Posaconazole is an orally administered second-generation triazole antifungal agent which inhibits lanosterol 14-alpha-demethylase, an enzyme that converts lanosterol to ergosterol, a vital component of the fungal cell membrane. Posaconazole has a favorable side effect profile, is safe and well tolerated when compared to the earlier generation of triazole antifungals. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1522472DOI Listing
January 2019
1 Read

Virulence of MRSA USA300 is enhanced by sub-inhibitory concentration of two different classes of antibiotics.

J Chemother 2018 Oct - Dec;30(6-8):384-388

a Department of Public Health and Infectious Diseases , Sapienza University , Rome , Italy.

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 is responsible of many kinds of infections of skin and soft-tissue. Antibiotic resistance, biofilm formation and the ability to adhere and invade are virulence factors that contribute to MRSA pathogenesis. In some cases, decreased bioavailability of antibiotics in systemic circulation could result; in these conditions sub-therapeutic levels of the antibiotics may be established, exposing bacteria to sub-inhibitory concentrations. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1533085DOI Listing
January 2019
1 Read

First report of polymyxin B activity in Klebsiella pneumoniae biofilm.

J Chemother 2019 Jan 19:1-5. Epub 2019 Jan 19.

a Laboratório de Microbiologia Médica, Universidade Federal de São João del-Rei (UFSJ) , Campus Centro Oeste Dona Lindu , Divinópolis , Minas Gerais , Brazil.

Considering the clinical importance of biofilm in medical devices and chronic infections, this study aimed to investigate the action of polymyxin B on Klebsiella pneumoniae (K. pneumoniae) biofilm. The experiments were performed using a biofilm formation assay and the interaction of polysorbate 80 was explored. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1558751DOI Listing
January 2019
4 Reads

Microbiota and cancer: an update.

J Chemother 2019 Jan 16:1-5. Epub 2019 Jan 16.

b First Department of Pedicatrics, Hematology and Oncology , University of Athens , Athens , Greece.

The number of microbes in the human intestine is approximately 1 × 10, while the number of eukaryotic cells in the human body is around 1 × 10. As a result of co-evolution of the host mucosal immune system and the microbiota, both have developed multiple mechanisms to maintain homeostasis. Nevertheless, when these mechanisms are disturbed by pathogenic bacteria, which invade this fragile environment, the immune system responds to the microbiota and may support tumour growth in the intestine. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1541046DOI Listing
January 2019
9 Reads

Carbapenem-Resistant Klebsiella Pneumoniae in Iran: a Systematic Review and Meta-Analysis.

J Chemother 2019 Feb 30;31(1):1-8. Epub 2018 Dec 30.

e Department of Microbiology , School of Medicine, Ardabil University of Medical Sciences , Ardabil , Iran.

The global emergence and dissemination of carbapenem-resistant (CR)-Klebsiella pneumoniae is an important healthcare concern owing to the limited therapeutic options that are available. The aim of the present study was to evaluate the prevalence of CR K. pneumoniae in different parts of Iran. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1533266DOI Listing
February 2019
1 Read
1.073 Impact Factor

Efficacy and safety of nivolumab in patients with non-small cell lung cancer: a retrospective study in clinical practice.

J Chemother 2018 Dec 30:1-5. Epub 2018 Dec 30.

c Oncologie multidisciplinaire et innovations thérapeutiques , AP-HM , Marseille , France.

Nivolumab, a fully human immunoglobulin monoclonal antibody inhibiting the programmed cell death protein-1 receptor, demonstrated robust efficacy and a manageable safety profile across multiple tumor types in clinical trials. The aim of the present study was to investigate the efficacy and safety of nivolumab for pretreated patients with non-small cell lung cancers in clinical practice. In this observational monocentric retrospective study, 98 patients were enrolled between February 2015 and February 2016. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1551753DOI Listing
December 2018

An Observational Study of the Efficacy and Safety of Voriconazole in a Real-Life Clinical Setting.

J Chemother 2019 Feb 22;31(1):49-57. Epub 2018 Dec 22.

a Department of Pharmacy , University Clinical Hospital Santiago de Compostela (SERGAS) , Santiago de Compostela , Spain.

An observational retrospective study in patients treated with voriconazole was made to evaluate outcomes, safety, drug interactions and characteristics of the treatment. A total of 96 patients were included. In 78. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1524085DOI Listing
February 2019
1 Read

Epidemiology and Microbiology of Skin and Soft Tissue Infections: Preliminary Results of a National Registry.

J Chemother 2019 Feb 3;31(1):9-14. Epub 2018 Dec 3.

y UOC Medicina Interna , Ospedale Umberto I , Enna , Italy.

Skin and soft tissue infections (SSTIs) represent a wide range of clinical conditions characterized by a considerable variety of clinical presentations and severity. Their aetiology can also vary, with numerous possible causative pathogens. While other authors previously published analyses on several types of SSTI and on restricted types of patients, we conducted a large nationwide surveillance programme on behalf of the Italian Society of Infectious and Tropical Diseases to assess the clinical and microbiological characteristics of the whole SSTI spectrum, from mild to severe life-threatening infections, in both inpatients and outpatients. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1536320DOI Listing
February 2019
4 Reads
1.073 Impact Factor

Transurethral Resection of the Prostate: are We Following the Guidelines? - Outcomes from the Global Prevalence of Infections in Urology (GPIU) Study.

J Chemother 2019 Feb 3;31(1):15-22. Epub 2018 Dec 3.

k Department of Urology, Paediatric Urology and Andrology , Justus-Liebig-University , Gießen , Germany.

Transurethral resection of the prostate (TURP) is one of the most common urological procedures. With the increasing rate of multiresistant infections including urosepsis, it is essential for all surgeons to adhere to the relevant international guidelines to prevent infectious complications. The aim of this prospective, multinational, multicentre study was to evaluate compliance with recommended infection control measures regarding TURP procedures. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1542552DOI Listing
February 2019
15 Reads

A phase II study: dose-dense carboplatin and paclitaxel as neoadjuvant chemotherapy in locally advanced cervical cancer.

J Chemother 2018 Jul;30(4):247-252

a Gynecologic Oncology Unit, Department of Biomedical Science and Human Oncology , University of Bari , Bari , Italy.

This study evaluates the efficacy and toxicity of dose-dense weekly paclitaxel and carboplatin as neoadjuvant chemotherapy in locally advanced cervical cancer (LACC). We collected 23 cases of LACC treated with weekly paclitaxel and carboplatin for nine cycles: 20 patients had complete or partial response to chemotherapy and were submitted to surgery, 3 with poor response received chemoradiation therapy. Pathologic examination showed complete response in four patients, myometrial invasion <50% in nine and >50% in seven patients, parametrial involvement in two, vaginal metastasis in one and lymphovascular space invasion, with positive margins, in another case. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1489601DOI Listing
July 2018
13 Reads

Prediction of the effect of voriconazole on the pharmacokinetics of non-steroidal anti-inflammatory drugs.

J Chemother 2018 Jul;30(4):240-246

c Department of Pharmacology , Tianjin Medical University , Tianjin , China.

To evaluate the impact of voriconazole on the pharmacokinetics of Non-steroidal anti-inflammatory drugs (NSAIDs). Pharmacokinetic and physiochemical properties of voriconazole and NSAIDs are applied to build physiologically based pharmacokinetic (PBPK) models using Gastroplus. The PBPK models of voriconazole and NSAIDs are verified by published studies, respectively. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1500197DOI Listing
July 2018
2 Reads

In vitro activity of ceftaroline and ceftobiprole against methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin isolated in paediatric patients.

J Chemother 2018 Oct - Dec;30(6-8):338-341. Epub 2018 Oct 30.

a Clinical Pathology Laboratory and Microbiology Unit , IRCCS Istituto Giannina Gaslini, Children's Hospital , Genova , Italy.

Minimal inhibitory concentrations (MIC, mg/l) of ceftaroline and ceftobiprole were evaluated over 70 methicillin-resistant Staphylococcus aureus (MRSA) strains with vancomycin MIC ≥1 isolated in a paediatric hospital. The proportion of non-wild-type strains (MIC > epidemiological cut off) was 18% for ceftobiprole and 64% for ceftaroline. Only 1. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1522473DOI Listing
October 2018
11 Reads

Pulmonary adverse events related to idelalisib therapy: A single centre experience.

J Chemother 2018 Oct 9:1-5. Epub 2018 Oct 9.

a CHU Reims, Service de Médecine Interne et Maladies Infectieuses et Tropicales , Reims , France.

Idelalisib is a potent and selective inhibitor of the PI3Kδ approved since September 2014 for the treatment of several types of B cell malignancies. Pulmonary adverse events related to idelalisib are an emerging serious adverse event. We report here a single centre cohort of 16 patients who initiated idelalisib as routine treatment. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1516184DOI Listing
October 2018
13 Reads
1.073 Impact Factor

Poor in vivo efficacy of caspofungin, micafungin and amphotericin B against wild-type Candida krusei clinical isolates does not correlate with in vitro susceptibility results.

J Chemother 2018 Jul 20;30(4):233-239. Epub 2018 Jul 20.

b Faculty of Medicine, Department of Medical Microbiology , University of Debrecen , Debrecen , Hungary.

We determined micafungin, caspofungin and amphotericin B (AMB) minimum inhibitory concentration (MICs) and killing rates in RPMI-1640 and in RPMI-1640 with 50% serum against three Candida krusei bloodstream isolates. MIC ranges in RPMI-1640 were 0.125-0. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1487150DOI Listing
July 2018
1 Read

Vinorelbine's anti-tumor actions may depend on the mitotic apoptosis, autophagy and inflammation: hypotheses with implications for chemo-immunotherapy of advanced cancers and pediatric gliomas.

J Chemother 2018 Jul 20;30(4):203-212. Epub 2018 Jul 20.

a Department of Neurosurgery , Neuroacademy Group, Memorial Hospital , Istanbul , Turkey.

Vinorelbine is a very potent chemotherapeutic agent which is used to treat a number of cancers including breast and non-small cell lung tumors. Vinorelbine mainly acts via blocking microtubules and induces a specific type of cell death called 'mitotic catastrophe/apoptosis' subsequent to mitotic slippage, which is the failure of cells to stay in a mitotic arrested state and replicating their DNA without cytokinesis. Glial tumor cells are especially sensitive to mitotic slippage. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1487149DOI Listing
July 2018
6 Reads

Clinical tools for chemotherapy toxicity prediction and survival in geriatric cancer patients.

J Chemother 2018 Jun 26:1-14. Epub 2018 Jun 26.

a Division of Medical Oncology , Sault Area Hospital , Sault Ste Marie , Ontario , Canada.

Chemotherapy is one of the main treatments for cancer and is associated in many cancers with significant benefits in overall and disease-free survival. Nevertheless, it is also associated with adverse effects that make its administration difficult in patients with comorbidities or decreased general status. Older patients belong more often to these categories because of the physiologic effects of aging in organ functions but also because of longer effects of chronic conditions in different organs. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1475442DOI Listing

Inflammatory biomarkers to guide diagnostic and therapeutic decisions in children presenting with fever without apparent source.

J Chemother 2018 Apr 5:1-11. Epub 2018 Apr 5.

b Division of Pediatric Infectious Disease, Department of Health Science , Anna Meyer Children's University Hospital, University of Florence , Florence , Italy.

A systematic review of literature from 2011 to 2016 was performed, in order to evaluate the diagnostic performance of inflammatory biomarkers in children with fever without apparent source and their usefulness in clinical decision-making. Data source was the Pubmed database. Thirteen studies were included, analysing the following biomarkers: erythrocyte sedimentation rate, white blood count, absolute neutrophil count, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) and the Lab-score (a combination of CRP, PCT and urine dipstick). Read More

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http://dx.doi.org/10.1080/1120009X.2018.1451430DOI Listing
April 2018
6 Reads

Paediatric HIV-1 infection: updated strategies of prevention mother-to-child transmission.

J Chemother 2018 Jul 29;30(4):193-202. Epub 2018 Mar 29.

a Department of Health Sciences , Meyer University Hospital, University of Florence , Florence , Italy.

Introduction: HIV-1 epidemiology is changing and prevention of mother-to-child transmission (PMTCT) strategies have been continuously optimized over time. However, the correct management of infected women during pregnancy is crucial for PMTCT and cases of vertical transmission continue to occur.

Objective: To review the most recent evidence regarding the prevention of MTCT in resource-rich and resource-limited settings, focalizing on new possible approaches. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1451030DOI Listing
July 2018
4 Reads

Impact of tigecycline versus imipenem-cilastatin on fibrinogen levels following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): a randomized-controlled study.

J Chemother 2018 Jul 22;30(4):224-232. Epub 2018 Mar 22.

d King Faisal Oncology Center , King Faisal Specialist Hospital & Research Centre , Riyadh , Saudi Arabia.

The aim of this prospective, randomized study was to compare the effects of tigecycline and imipenem-cilastatin on fibrinogen levels in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Patients were empirically randomized to receive tigecycline or imipenem-cilastatin. Fibrinogen levels were measured in both patient groups on days 1, 3, 5 and 8 of antibiotic therapy and 3 days after antibiotic therapy completion. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1452333DOI Listing
July 2018
7 Reads

Susceptibility of Escherichia coli to nitroxoline, an option for uncomplicated urinary tract infections - the first report from Croatia.

J Chemother 2018 May 20;30(3):189-191. Epub 2018 Mar 20.

b School of Medicine , University of Zagreb , Zagreb , Croatia.

Nitroxoline (NTX), 5-nitro-8-hydroxyquinoline is an oral antibiotic with mechanism of bacteriostatic activity that is based on chelation of divalent cations required for bacterial RNA polymerase. Susceptibility to NTX of 100 Escherichia coli urine isolates was determined at the Department of Clinical and Molecular Microbiology, University Hospital Centre Zagreb during September and October 2017. Antimicrobial susceptibility was tested by disc diffusion and the results were interpreted according to the European Committee for Antimicrobial Susceptibility Testing (EUCAST) standards. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1452585DOI Listing
May 2018
11 Reads

Early abdominal aortic graft infection due to Propionibacterium acnes: a case report and review of the literature.

J Chemother 2018 May 20;30(3):185-188. Epub 2018 Mar 20.

a Department of Medicine, Infectious Diseases Unit , University Hospital of Perugia , Perugia , Italy.

Propionibacterium acnes is a member of the human microbiota that has been recently associated with late-onset infections of indwelling devices, especially shoulder prosthesis. Aortic graft infection are rare events with significant morbidity and mortality. Here, we describe the case of an abdominal aortic graft infection due to P. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1451453DOI Listing
May 2018
5 Reads

Comparative in vitro activity of ceftaroline and comparator agents against nosocomial Gram-negative and Gram-positive clinically significant bacterial isolates from patients in a teaching hospital in Kuwait.

J Chemother 2018 Jul 21;30(4):213-223. Epub 2018 Feb 21.

a Faculty of Medicine, Department of Microbiology , Kuwait University , Jabriya , Kuwait.

The objective was to test the in vitro activities of ceftaroline and comparator agents against clinical isolates of Gram-negative and Gram-positive bacteria. Isolates were identified with VITEK II. Susceptibility testing was with E test. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2018.1
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http://dx.doi.org/10.1080/1120009X.2018.1438768DOI Listing
July 2018
8 Reads

Impact of cephalosporin restriction on incidence of infections with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in an endemic setting.

J Chemother 2018 May 12;30(3):150-156. Epub 2018 Feb 12.

a Department of Infectious Diseases , University Medical Centre Ljubljana , Ljubljana , Slovenia.

Decreasing cephalosporin use was described as an effective intervention in decreasing the incidence of infections caused by Klebsiella pneumoniae harbouring extended-spectrum beta-lactamase (ESBLKP). Due to sustained increased levels of infections caused by ESBLKP, a multifaceted antibiotic stewardship intervention aimed to decrease cephalosporin use was carried out at a large medical unit of a teaching hospital. All cephalosporins except the first-generation were restricted and could only be prescribed after authorization by an infectious disease physician. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1434917DOI Listing
May 2018
4 Reads

Efficacy and safety of tigecycline monotherapy versus combination therapy for the treatment of hospital-acquired pneumonia (HAP): a meta-analysis of cohort studies.

J Chemother 2018 May 6;30(3):172-178. Epub 2018 Feb 6.

a Department of Pharmacy , Xuan Wu Hospital Capital Medical University , Beijing , China.

The broad spectrum antibiotic tigecycline shows promising efficacy against many multiple drug resistant (MDR) pathogens. However, its clinical efficacy in the treatment of hospital-acquired pneumonia (HAP) is unclear. Several studies have reported on the treatment failures of tigecycline monotherapy, suggesting that it may not be sufficient to control severe infections. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1425279DOI Listing
May 2018
3 Reads

The calm before the storm: clinical observations of Middle East respiratory syndrome (MERS) patients.

J Chemother 2018 May 1;30(3):179-182. Epub 2018 Feb 1.

c Hospital Medicine , Johns Hopkins Aramco Healthcare , Dhahran , Saudi Arabia.

Background: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection emerged in 2012. The majority of cases occurred in the Kingdom of Saudi Arabia and the disease carries a high case fatality rate.

Methods: We present three MERS-CoV cases and highlight the salient clinical features and laboratory, and radiographic characteristics. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1429236DOI Listing
May 2018
3 Reads

The current role of glycopeptides in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in not neutropenic adults: the viewpoint of a group of Italian experts.

J Chemother 2018 May 30;30(3):157-171. Epub 2018 Jan 30.

c Università degli Studi di Bologna/Ospedale Sant'Orsola-Malpighi, Bologna, Italy - Dipartimento di Scienze Mediche e Chirurgiche, Settore Malattie Infettive.

Staphylococcus aureus is still an important problem in clinical and therapeutic area, worldwide. In Italy, in recent years, methicillin resistance remained stable, yet considerably high, the percentage of strains of MRSA being around 40%. It was deemed interesting and timely to carry out a consensus conference using the RAND/UCLA method to collect the opinion of a group of experts in infectious diseases on the role of glycopeptides in the management of MRSA infections within several clinical scenarios and namely in pneumonia, bacteremia and endocarditis, joint replacement infections, skin and soft tissue infections, diabetic foot, abdominal infections and central nervous system infections. Read More

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http://dx.doi.org/10.1080/1120009X.2017.1420610DOI Listing
May 2018
18 Reads

Treatment of a Klebsiella pneumoniae KPC cellulitis and gut decolonization with ceftazidime/avibactam in a migrant from Libya.

J Chemother 2018 May 16;30(3):183-184. Epub 2018 Jan 16.

a First division of Infectious Diseases , Cotugno Hospital, AORN dei Colli , Naples , Italy.

KPC-producing Klebsiella pneumoniae (KPC-Kp) is nowadays a global concern. Ceftazidime/avibactam is the most promising novel antibiotic combination available at the moment. We describe the case of a migrant with no risk factors for an infection due to multidrug resistant bacteria. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1424504DOI Listing
May 2018
5 Reads

Analysis of the spectrum and antibiotic resistance of uropathogens in outpatients at a tertiary hospital.

J Chemother 2018 May 5;30(3):145-149. Epub 2018 Jan 5.

a Department of Pharmacy, Southwest Hospital , Third Military Medical University , Chongqing , China.

The objective of this study was to analyse the distribution and antimicrobial resistance of bacterial uropathogens isolated from outpatients at Henan Provincial People's Hospital. A total of 1419 samples from 823 newly diagnosed and 596 recurrent UTI outpatients culture positive. Escherichia coli was the most common uropathogen. Read More

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http://dx.doi.org/10.1080/1120009X.2017.1418646DOI Listing
May 2018
7 Reads

Hepatic veno-occlusive disease during isavuconazole administration.

J Chemother 2018 02 26;30(1):63-64. Epub 2017 Dec 26.

d Infectious Diseases Unit , Istituto Giannina Gaslini , Genoa , Italy.

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http://dx.doi.org/10.1080/1120009X.2017.1418619DOI Listing
February 2018
6 Reads

Actual role of older oral antibiotics in the treatment of resistant Urinary Tract Infections (UTIs).

J Chemother 2017 Dec;29(sup1)

c Department of Health Sciences, Clinical Pharmacology and Oncology Section , University of Florence , Florence , Italy.

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http://dx.doi.org/10.1080/1120009X.2017.1380394DOI Listing
December 2017
9 Reads

Multi-drug-resistant Gram-negative bacteria causing urinary tract infections: a review.

J Chemother 2017 Dec;29(sup1):2-9

a Department of Diagnostics and Public Health , University of Verona , Verona , Italy.

Urinary tract infections (UTIs) are among the most frequent infectious diseases affecting humans, and represent an important public health problem with a substantial economic burden. Due to the high empiric use of antibiotics for the treatment of UTI, antibacterial resistance of Enterobacteriaceae, specifically the main uropathogens Escherichia coli and Klebsiella pneumoniae, has significantly increased worldwide. In this article the worldwide epidemiology of resistant Gram-negative bacteria causing UTIs, with a special focus on extended spectrum beta lactamase (ESBL) positive pathogens, as well as new threats such as multi-drug-resistant (MDR) clones (e. Read More

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http://dx.doi.org/10.1080/1120009X.2017.1380395DOI Listing
December 2017
5 Reads