4,190 results match your criteria Journal of Cellular and Molecular Medicine [Journal]


Machine-learning based radiogenomics analysis of MRI features and metagenes in glioblastoma multiforme patients with different survival time.

J Cell Mol Med 2019 Apr 18. Epub 2019 Apr 18.

Department of Interventional Radiology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.

Background: This study aimed to examine multi-dimensional MRI features' predictability on survival outcome and associations with differentially expressed Genes (RNA Sequencing) in groups of glioblastoma multiforme (GBM) patients.

Methods: Radiomics features were extracted from segmented lesions of T2-FLAIR MRI data of 137 GBM patients. Radiomics features include intensity, shape and textural features in seven classes were included in the analysis. Read More

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http://dx.doi.org/10.1111/jcmm.14328DOI Listing

LncRNA KCNQ1OT1 enhanced the methotrexate resistance of colorectal cancer cells by regulating miR-760/PPP1R1B via the cAMP signalling pathway.

Authors:
Di Xian Yu Zhao

J Cell Mol Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Emergency Surgery, Sichuan Academy of Medical Sciences & Sichaun Provincial People's Hospital, Chengdu, Sichuan, China.

We aimed to explore the mechanism of the KCNQ1OT1/miR-760/PPP1R1B axis acting to regulate methotrexate (MTX) resistance of colorectal cancer (CRC). Differentially expressed mRNAs and lncRNAs in MTX-sensitive CRC cell lines and MTX-resistant cell lines were determined through microarray analysis. Application of bioinformatics analysis was aimed to uncover the relationships among the lncRNAs/miRNAs/mRNAs, and to demonstrate the effects of cAMP signalling pathway in MTX-resistant CRC. Read More

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http://dx.doi.org/10.1111/jcmm.14071DOI Listing

Salidroside ameliorates Adriamycin nephropathy in mice by inhibiting β-catenin activity.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, China.

Salidroside is a major phenylethanoid glycoside in Rhodiola rosea L., a traditional Chinese medicine, with multiple biological activities. It has been shown that salidroside possesses protective effects for alleviating diabetic renal dysfunction, contrast-induced-nephropathy and other kidney diseases. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14340
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http://dx.doi.org/10.1111/jcmm.14340DOI Listing
April 2019
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Role of Jagged1/STAT3 signalling in platinum-resistant ovarian cancer.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynaecology, Renmin Hospital of Wuhan University, Wuhan, P.R. China.

Jagged1, the essential ligand of the Notch signalling pathway, is highly expressed in metastatic prostate cancer, and its high expression in breast cancer is linked to poor survival rates. However, the mechanism of Jagged1's involvement in platinum-resistant ovarian cancer has not been thoroughly elucidated to date. The purpose of the present study was to investigate the roles of Jagged1 in the platinum resistance of ovarian cancer and its possible mechanisms. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14286
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http://dx.doi.org/10.1111/jcmm.14286DOI Listing
April 2019
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Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Nephrology, The Key Laboratory of Kidney Disease and Blood Purification of Hunan Province, Second Xiangya Hospital at Central South University, Changsha, China.

Renal interstitial fibrosis is a common pathological feature in progressive kidney diseases currently lacking effective treatment. Nicotinamide (NAM), a member of water-soluble vitamin B family, was recently suggested to have a therapeutic potential for acute kidney injury (AKI) in mice and humans. The effect of NAM on chronic kidney pathologies, including renal fibrosis, is unknown. Read More

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http://doi.wiley.com/10.1111/jcmm.14285
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April 2019
2 Reads

Xanthatin inhibits STAT3 and NF-κB signalling by covalently binding to JAK and IKK kinases.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China.

Aberrant activation of the signal transducer and activator of transcription 3 (STAT3) and the nuclear factor-κB (NF-κB) signalling pathways is associated with the development of cancer and inflammatory diseases. JAKs and IKKs are the key regulators in the STAT3 and NF-κB signalling respectively. Therefore, the two families of kinases have been the major targets for developing drugs to regulate the two signalling pathways. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14322
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http://dx.doi.org/10.1111/jcmm.14322DOI Listing
April 2019
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miRNA-210-3p regulates trophoblast proliferation and invasiveness through fibroblast growth factor 1 in selective intrauterine growth restriction.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Fetal Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Selective intrauterine growth restriction (sIUGR), which affects approximately 10%-15% of monochorionic (MC) twin pregnancies, is highly associated with intrauterine foetal death and neurological impairment in both twins. Data suggest that unequal sharing of the single placenta is the main contributor to birth weight discordance. While MC twins and their placenta derive from a single zygote and harbour almost identical genetic material, the underlying mechanisms of phenotypic discrepancies in MC twins remain unclear. Read More

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http://dx.doi.org/10.1111/jcmm.14335DOI Listing
April 2019
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Augmenter of liver regeneration protects the kidney from ischaemia-reperfusion injury in ferroptosis.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.

Acute kidney injury (AKI) is a common and severe clinical condition with high morbidity and mortality. Ischaemia-reperfusion (I/R) injury remains the major cause of AKI in the clinic. Ferroptosis is a recently discovered form of programmed cell death (PCD) that is characterized by iron-dependent accumulation of reactive oxygen species (ROS). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14302
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April 2019
3 Reads

AMP-activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Institute of Digestive Diseases, The First Affiliated Hospital, Nanchang, China.

Adenine monophosphate-activated protein kinase (AMPK) is a fuel sensing enzyme that is activated in shortage of energy and inhibited in its surplus. Cancer is a metabolic disease characteristic of aerobic glycolysis, namely Warburg effect, and possesses heterogeneity featured by spatiotemporal hypoxia and normoxia, where AMPK is deeply implicated. The present study delineates the regulation of mitochondrial functions by AMPK in cancer cells. Read More

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http://dx.doi.org/10.1111/jcmm.14279DOI Listing
April 2019
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Alpha lipoic acid inhibits oxidative stress-induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injury.

J Cell Mol Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Anesthesiology, the Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.

Alpha lipoic acid (ALA) is a powerful antioxidant which has been widely used in the treatment of different system diseases, such as cardiovascular and cerebrovascular diseases. But, there are few studies that refer to protective effects and potential mechanisms on traumatic brain injury (TBI). This study was carried out to investigate the neuroprotective effect following TBI and illuminate the underlying mechanism. Read More

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http://dx.doi.org/10.1111/jcmm.14296DOI Listing

Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis.

J Cell Mol Med 2019 Apr 14. Epub 2019 Apr 14.

Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. of China.

Increasing evidence indicates that osteoarthritis (OA) is a musculoskeletal disease affecting the whole joint, including both cartilage and subchondral bone. Reactive oxygen species (ROS) have been demonstrated to be one of the important destructive factors during early-stage OA development. The objective of this study was to investigate isorhamnetin (Iso) treatment on osteoclast formation and chondrocyte protection to attenuate OA by modulating ROS. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14333
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http://dx.doi.org/10.1111/jcmm.14333DOI Listing
April 2019
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The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.

J Cell Mol Med 2019 Apr 14. Epub 2019 Apr 14.

Department of Pathology and Forensic Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.

Transforming growth factor beta (TGFβ) plays a crucial role in tissue fibrosis. A number of studies have shown that TGFβ3 significantly attenuated tissue fibrosis. However, the mechanism involved in this effect is poorly understood. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14313
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http://dx.doi.org/10.1111/jcmm.14313DOI Listing
April 2019
4 Reads

NF-κB p65 promotes ovarian cancer cell proliferation and migration via regulating mortalin.

J Cell Mol Med 2019 Apr 14. Epub 2019 Apr 14.

Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.

Previous studies show that mortalin, a HSP70 family member, contributes to the development and progression of ovarian cancer. However, details of the transcriptional regulation of mortalin remain unknown. We aimed to determine whether NF-κB p65 participates in the regulation of mortalin expression in ovarian cancer cells and to elucidate the underlying mechanism. Read More

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http://dx.doi.org/10.1111/jcmm.14325DOI Listing
April 2019
1 Read

Anti-human CD9 antibody Fab fragment impairs the internalization of extracellular vesicles and the nuclear transfer of their cargo proteins.

J Cell Mol Med 2019 Apr 13. Epub 2019 Apr 13.

College of Medicine, Touro University Nevada, Henderson, Nevada.

The intercellular communication mediated by extracellular vesicles (EVs) has gained international interest during the last decade. Interfering with the mechanisms regulating this cellular process might find application particularly in oncology where cancer cell-derived EVs play a role in tumour microenvironment transformation. Although several mechanisms were ascribed to explain the internalization of EVs, little is our knowledge about the fate of their cargos, which are crucial to mediate their function. Read More

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http://dx.doi.org/10.1111/jcmm.14334DOI Listing
April 2019
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Diversity of dermal fibroblasts as major determinant of variability in cell reprogramming.

J Cell Mol Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

Induced pluripotent stem cells (iPSCs) are adult somatic cells genetically reprogrammed to an embryonic stem cell-like state. Notwithstanding their autologous origin and their potential to differentiate towards cells of all three germ layers, iPSC reprogramming is still affected by low efficiency. As dermal fibroblast is the most used human cell for reprogramming, we hypothesize that the variability in reprogramming is, at least partially, because of the skin fibroblasts used. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14316
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April 2019
2 Reads

Long noncoding RNA LINC00511 induced by SP1 accelerates the glioma progression through targeting miR-124-3p/CCND2 axis.

J Cell Mol Med 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, P.R. China.

Mounting evidence suggests the vital roles of long noncoding RNA (lncRNAs) in the glioma. However, the role of LINC00511 in gliomagenesis is still uncovered. Here, in this study, we aim to investigate the effects of LINC00511 on the glioma cancer phenotype and its deepgoing mechanism. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14331
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http://dx.doi.org/10.1111/jcmm.14331DOI Listing
April 2019
2 Reads

Concomitant overexpression of triple antioxidant enzymes selectively increases circulating endothelial progenitor cells in mice with limb ischaemia.

J Cell Mol Med 2019 Apr 11. Epub 2019 Apr 11.

Center for Precision Medicine and Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, Missouri.

Endothelial progenitor cells (EPCs) are a group of heterogeneous cells in bone marrow (BM) and blood. Ischaemia increases reactive oxygen species (ROS) production that regulates EPC number and function. The present study was conducted to determine if ischaemia-induced ROS differentially regulated individual EPC subpopulations using a mouse model concomitantly overexpressing superoxide dismutase (SOD)1, SOD3 and glutathione peroxidase. Read More

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http://dx.doi.org/10.1111/jcmm.14287DOI Listing

The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux.

J Cell Mol Med 2019 Apr 11. Epub 2019 Apr 11.

Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong.

Impaired autophagic degradation of intracellular lipids is causally linked to the development of non-alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic autophagic flux could therefore have therapeutic potentials for this increasingly prevalent disease. Herein, we investigated the effects of polydatin, a natural precursor of resveratrol, in a murine nutritional model of NASH and a cell line model of steatosis. Read More

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http://dx.doi.org/10.1111/jcmm.14320DOI Listing

Down-regulation of miRNA-27b-3p suppresses keratinocytes apoptosis in oral lichen planus.

J Cell Mol Med 2019 Apr 11. Epub 2019 Apr 11.

Department of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Oral lichen planus (OLP) is considered a precancerous lesion with no known cure. Recent studies reported that abnormal regulation of apoptosis was involved in the pathogenesis of OLP. Next generation sequencing was used to screen the candidate microRNAs and genes in biopsies from patients with OLP and healthy mucosa. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14324
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http://dx.doi.org/10.1111/jcmm.14324DOI Listing
April 2019
2 Reads

The role of autophagy in the pathogenesis of exposure keratitis.

J Cell Mol Med 2019 Apr 11. Epub 2019 Apr 11.

Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, China.

Incomplete tear film spreading and eyelid closure can cause defective renewal of the ocular surface and air exposure-induced epithelial keratopathy (EK). In this study, we characterized the role of autophagy in mediating the ocular surface changes leading to EK. Human corneal epithelial cells (HCECs) and C57BL/6 mice were employed as EK models, respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14310
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http://dx.doi.org/10.1111/jcmm.14310DOI Listing
April 2019
5 Reads

Macrophage migration inhibitory factor promotes renal injury induced by ischemic reperfusion.

J Cell Mol Med 2019 Apr 9. Epub 2019 Apr 9.

Department of Medicine and Therapeutics, Department of Anatomical and Cellular Pathology, Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong, Hong Kong, China.

Macrophage migration inhibitory factor (MIF) is pleiotropic cytokine that has multiple effects in many inflammatory and immune diseases. This study reveals a potential role of MIF in acute kidney injury (AKI) in patients and in kidney ischemic reperfusion injury (IRI) mouse model in MIF wild-type (WT) and MIF knockout (KO) mice. Clinically, plasma and urinary MIF levels were largely elevated at the onset of AKI, declined to normal levels when AKI was resolved and correlated tightly with serum creatinine independent of disease causes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14234
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April 2019
4 Reads

Induced pluripotent stem cell-conditional medium inhibits H9C2 cardiomyocytes apoptosis via autophagy flux and Wnt/β-catenin pathway.

J Cell Mol Med 2019 Apr 7. Epub 2019 Apr 7.

Center of Scientific Research, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Induced pluripotent stem cell-derived conditioned medium (iPS-CM) could improve cell viability in many types of cells and may be a better alternative for the treatment of myocardial infarction. This study aimed to examine the influence of iPS-CM on anti-apoptosis and the proliferation of H9C2 cardiomyocytes and investigate the underlying mechanisms. H9C2 cardiomyocytes were exposed to 200 μmol/L hydrogen peroxide (H O ) for 24 hours with or without pre-treatment with iPS-CM. Read More

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http://dx.doi.org/10.1111/jcmm.14327DOI Listing
April 2019
2 Reads

Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages.

J Cell Mol Med 2019 Apr 7. Epub 2019 Apr 7.

Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.

Disordered intestinal metabolism is highly correlated with atherosclerotic diseases. Resveratrol protects against atherosclerotic diseases. Accordingly, this study aims to discover novel intestinal proatherosclerotic metabolites and potential therapeutic targets related to the anti-atherosclerotic effects of resveratrol. Read More

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http://dx.doi.org/10.1111/jcmm.14323DOI Listing
April 2019
2 Reads

EYA4 serves as a prognostic biomarker in hepatocellular carcinoma and suppresses tumour angiogenesis and metastasis.

J Cell Mol Med 2019 Apr 7. Epub 2019 Apr 7.

The Third Department of Hepatic Surgery, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China.

Eye absent homolog 4 (EYA4) has been demonstrated to be down-regulated in hepatocellular carcinoma (HCC), but its biological function and the mechanism in HCC angiogenesis and metastasis remain largely unknown. Herein, we showed that EYA4 expression was frequently low in HCC tissue samples compared with matched adjacent non-tumourous tissues. In the analysis of 302 HCC specimens, we revealed that decreased expression of EYA4 correlated with tumour differentiation status. Read More

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http://dx.doi.org/10.1111/jcmm.14309DOI Listing
April 2019
1 Read

RBM10 inhibits cell proliferation of lung adenocarcinoma via RAP1/AKT/CREB signalling pathway.

J Cell Mol Med 2019 Apr 6. Epub 2019 Apr 6.

Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.

Initial functional studies have demonstrated that RNA-binding motif protein 10 (RBM10) can promote apoptosis and suppress cell proliferation; however, the results of several studies suggest a tumour-promoting role for RBM10. Herein, we assessed the involvement of RBM10 in lung adenocarcinoma cell proliferation and explored the potential molecular mechanism. We found that, both in vitro and in vivo, RBM10 overexpression suppresses lung adenocarcinoma cell proliferation, while its knockdown enhances cell proliferation. Read More

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http://dx.doi.org/10.1111/jcmm.14263DOI Listing
April 2019
1 Read

PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.

J Cell Mol Med 2019 Apr 6. Epub 2019 Apr 6.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Diabetic nephropathy (DN) is a chronic inflammatory disease triggered by disordered metabolism. Recent studies suggested that protein tyrosine phosphatase non-receptor type 2 (PTPN2) could ameliorate metabolic disorders and suppress inflammatory responses. This study investigated PTPN2's role in modulating DN and the possible cellular mechanisms involved. Read More

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http://dx.doi.org/10.1111/jcmm.14304DOI Listing
April 2019
1 Read

Silencing long non-coding RNA MEG3 accelerates tibia fraction healing by regulating the Wnt/β-catenin signalling pathway.

J Cell Mol Med 2019 Apr 6. Epub 2019 Apr 6.

Department of Orthopaedics, Luhe People's Hospital of Nanjing, Nanjing, P.R. China.

As fracture healing is related to gene expression, fracture healing is prospected to be implicated in long non-coding RNAs (lncRNAs). This study focuses on the effects of epigenetic silencing of long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) on fracture healing by regulating the Wnt/β-catenin signalling pathway. Genes expressed in fracture were screened using bioinformatics and the subcellular location of MEG3 was determined using FISH. Read More

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http://dx.doi.org/10.1111/jcmm.14229DOI Listing

Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway.

J Cell Mol Med 2018 Dec 26. Epub 2018 Dec 26.

Laboratory of Vascular Biology, Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China.

Rutaecarpine attenuates hypertensive cardiac hypertrophy in the rats with abdominal artery constriction (AAC); however, its mechanism of action remains largely unknown. Our previous study indicated that NADPH oxidase 4 (Nox4) promotes angiotensin II (Ang II)-induced cardiac hypertrophy through the pathway between reactive oxygen species (ROS) and a disintegrin and metalloproteinase-17 (ADAM17) in primary cardiomyocytes. This research aimed to determine whether the Nox4-ROS-ADAM17 pathway is involved in the protective action of rutaecarpine against hypertensive cardiac hypertrophy. Read More

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http://dx.doi.org/10.1111/jcmm.14308DOI Listing
December 2018
1 Read

Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways.

J Cell Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin, PR China.

Aucubin (AU) is the main active ingredient of Aucuba japonica which has showed many positive effects such as anti-inflammation and liver protection. Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. In this research, we explored the effects of AU on the tyloxapol-induced NAFLD in mice and apolipoprotein C-III (apoC-III) induced-3T3L1 cells. Read More

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http://dx.doi.org/10.1111/jcmm.14293DOI Listing
April 2019
4 Reads

The role of post-translational modifications in cardiac hypertrophy.

J Cell Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, China.

Pathological cardiac hypertrophy involves excessive protein synthesis, increased cardiac myocyte size and ultimately the development of heart failure. Thus, pathological cardiac hypertrophy is a major risk factor for many cardiovascular diseases and death in humans. Extensive research in the last decade has revealed that post-translational modifications (PTMs), including phosphorylation, ubiquitination, SUMOylation, O-GlcNAcylation, methylation and acetylation, play important roles in pathological cardiac hypertrophy pathways. Read More

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http://dx.doi.org/10.1111/jcmm.14330DOI Listing
April 2019
1 Read

The role of insulin in transdifferentiated hepatocyte proliferation and function in serum-free medium.

J Cell Mol Med 2019 Apr 4. Epub 2019 Apr 4.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, P. R. China.

Transdifferentiated hepatocytes are potential seeding cells for bioartificial liver (BAL) treatment, and it is important to obtain a sufficient number of functional hepatocytes in serum-free medium (SFM). Although insulin plays an essential role in promoting cell proliferation and metabolism, the functions of insulin in transdifferentiated cells remain poorly understood. Here, we found that 1. Read More

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http://dx.doi.org/10.1111/jcmm.14303DOI Listing
April 2019
6 Reads

DNA methylation-reprogrammed oxytocin receptor underlies insensitivity to oxytocin in pre-eclamptic placental vasculature.

J Cell Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Institute for Fetology and Department of Obstetrics and Gynecology, First Hospital of Soochow University, Suzhou, China.

Pre-eclampsia is associated with inadequate placental blood flow and placental ischaemia. Placental vascular tone is essential for maintaining adequate placental blood flow. Oxytocin is increased in placental system at late pregnancy and onset of labour, and presented strongly concentration-dependent contractions in placental vascular, suggesting that oxytocin could be involved in regulating placental vascular tone and circulation. Read More

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http://dx.doi.org/10.1111/jcmm.14299DOI Listing
April 2019
2 Reads

Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma.

J Cell Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China.

The long noncoding RNAs (lncRNAs) have been increasingly appreciated as key players underlying tumourigenesis and hold great potentials as prognostic biomarkers and therapeutic targets. However, their roles in head neck squamous cell carcinoma (HNSCC) have remained incompletely known. Here, we sought to reveal the oncogenic roles and clinical significance of a tumour-associated lncRNA, zinc finger E-box binding homeobox 2 antisense RNA 1 (ZEB2-AS1), in HNSCC. Read More

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http://dx.doi.org/10.1111/jcmm.14318DOI Listing
April 2019
1 Read

SDF-1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception.

J Cell Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Institute of Anatomy, University of Bern, Bern, Switzerland.

The precise mechanisms of SDF-1 (CXCL12) in angiogenesis are not fully elucidated. Recently, we showed that Notch inhibition induces extensive intussusceptive angiogenesis by recruitment of mononuclear cells and it was associated with increased levels of SDF-1 and CXCR4. In the current study, we demonstrated SDF-1 expression in liver sinusoidal vessels of Notch1 knockout mice with regenerative hyperplasia by means of intussusception, but we did not detect any SDF-1 expression in wild-type mice with normal liver vessel structure. Read More

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http://dx.doi.org/10.1111/jcmm.14269DOI Listing

Augmented CD133 expression in distal margin correlates with poor prognosis in colorectal cancer.

J Cell Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Cancer Research Program 4, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India.

Pathological assessment of excised tumour and surgical margins in colorectal cancer (CRC) play crucial role in prognosis after surgery. Molecular assessment of margins could be more sensitive and informative than conventional histopathological analysis. Considering this view, we evaluated the distal surgical margins for expression of cancer stem cell (CSC) markers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14284
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http://dx.doi.org/10.1111/jcmm.14284DOI Listing
April 2019
3 Reads

Identification of cell and disease specific microRNAs in glomerular pathologies.

J Cell Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Department of Medicine/Nephrology, Friedrich-Alexander University Erlangen, Erlangen, Germany.

MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression in physiological processes as well as in diseases. Currently miRs are already used to find novel mechanisms involved in diseases and in the future, they might serve as diagnostic markers. To identify miRs that play a role in glomerular diseases urinary miR-screenings are a frequently used tool. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14270
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http://dx.doi.org/10.1111/jcmm.14270DOI Listing
April 2019
3 Reads

miR-193a/b-3p relieves hepatic fibrosis and restrains proliferation and activation of hepatic stellate cells.

J Cell Mol Med 2019 Apr 3. Epub 2019 Apr 3.

Department of Immunology, Mudanjiang Medical College, Mudanjiang, Heilongjiang, People's Republic of China.

MicroRNAs (miRNAs) have been confirmed to participate in liver fibrosis progression and activation of hepatic stellate cells (HSCs). In this study, the role of miR-193a/b-3p in concanavalin A (ConA)-induced liver fibrosis in mice was evaluated. According to the results, the expression of miR-193a/b-3p was down-regulated in liver tissues after exposure to ConA. Read More

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http://dx.doi.org/10.1111/jcmm.14210DOI Listing
April 2019
1 Read

Nerve sprouting and neurogenic inflammation characterize the neurogenic detrusor overactive bladder of patients no longer responsive to drug therapies.

J Cell Mol Med 2019 Apr 3. Epub 2019 Apr 3.

Department of Experimental and Clinical Medicine, Histology and Embryology Research Unit, University of Florence, Florence, Italy.

Urothelium and Lamina Propria (LP) are considered an integrate sensory system which is able to control the detrusor activity. Complete supra-sacral spinal cord lesions cause Neurogenic Detrusor Overactivity (NDO) whose main symptoms are urgency and incontinence. NDO therapy at first consists in anti-muscarinic drugs; secondly, in intra-vesical injection of botulinum toxin. Read More

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http://dx.doi.org/10.1111/jcmm.14294DOI Listing
April 2019
2 Reads

Therapeutic efficacy of anti-MMP9 antibody in combination with nab-paclitaxel-based chemotherapy in pre-clinical models of pancreatic cancer.

J Cell Mol Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgery, Indiana University School of Medicine, South Bend, Indiana.

Matrix metalloproteinase 9 (MMP9) is involved in the proteolysis of extracellular proteins and plays a critical role in pancreatic ductal adenocarcinoma (PDAC) progression, invasion and metastasis. The therapeutic potential of an anti-MMP9 antibody (αMMP9) was evaluated in combination with nab-paclitaxel (NPT)-based standard cytotoxic therapy in pre-clinical models of PDAC. Tumour progression and survival studies were performed in NOD/SCID mice. Read More

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http://dx.doi.org/10.1111/jcmm.14242DOI Listing
April 2019
1 Read

Mitochondrial implications in human pregnancies with intrauterine growth restriction and associated cardiac remodelling.

J Cell Mol Med 2019 Apr 2. Epub 2019 Apr 2.

Muscle Research and Mitochondrial Function Laboratory, Faculty of Medicine and Health Sciences, Internal Medicine Service-Hospital Clínic of Barcelona, Cellex-IDIBAPS, University of Barcelona, Barcelona, Spain.

Intrauterine growth restriction (IUGR) is an obstetric complication characterised by placental insufficiency and secondary cardiovascular remodelling that can lead to cardiomyopathy in adulthood. Despite its aetiology and potential therapeutics are poorly understood, bioenergetic deficits have been demonstrated in adverse foetal and cardiac development. We aimed to evaluate the role of mitochondria in human pregnancies with IUGR. Read More

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http://dx.doi.org/10.1111/jcmm.14282DOI Listing
April 2019
3 Reads

p62 aggregates mediated Caspase 8 activation is responsible for progression of ovarian cancer.

J Cell Mol Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, P.R. China.

Increasing evidence suggests that p62/SQSTM1 functions as a signalling centre in cancer. However, the role of p62 in tumour development depends on the interacting factors it recruits and its precise regulatory mechanism remains unclear. In this study, we investigated the pro-death signalling recruitment of p62 with the goal of improving anti-tumour drug effects in ovarian cancer treatment. Read More

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http://dx.doi.org/10.1111/jcmm.14288DOI Listing
April 2019
2 Reads

The mechanical effects of CRT promoting autophagy via mitochondrial calcium uniporter down-regulation and mitochondrial dynamics alteration.

J Cell Mol Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, PR China.

The mechanism of cardiac resynchronization therapy (CRT) remains unclear. In this study, mitochondria calcium uniporter (MCU), dynamin-related protein-1 (DNM1L/Drp1) and their relationship with autophagy in heart failure (HF) and CRT are investigated. Thirteen male beagle's dogs were divided into three groups (sham, HF, CRT). Read More

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http://dx.doi.org/10.1111/jcmm.14227DOI Listing

PI3-kinase/Akt pathway-regulated membrane transportation of acid-sensing ion channel 1a/Calcium ion influx/endoplasmic reticulum stress activation on PDGF-induced HSC Activation.

J Cell Mol Med 2019 Apr 2. Epub 2019 Apr 2.

School of Pharmacy, Anhui Medical University, Hefei, China.

Acid-sensing ion channel 1a (ASIC1a) allows Na and Ca flow into cells. It is expressed during inflammation, in tumour and ischaemic tissue, in the central nervous system and non-neuronal injury environments. Endoplasmic reticulum stress (ERS) is caused by the accumulation of misfolded proteins that interferes with intracellular calcium homoeostasis. Read More

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http://dx.doi.org/10.1111/jcmm.14275DOI Listing
April 2019
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iPSCs: A powerful tool for skeletal muscle tissue engineering.

J Cell Mol Med 2019 Apr 1. Epub 2019 Apr 1.

Grupo de Investigación, Traslacional con células iPS, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), Madrid, Spain.

Both volumetric muscle loss (VML) and muscle degenerative diseases lead to an important decrease in skeletal muscle mass, condition that nowadays lacks an optimal treatment. This issue has driven towards an increasing interest in new strategies in tissue engineering, an emerging field that can offer very promising approaches. In addition, the discovery of induced pluripotent stem cells (iPSCs) has completely revolutionized the actual view of personalized medicine, and their utilization in skeletal muscle tissue engineering could, undoubtedly, add myriad benefits. Read More

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http://dx.doi.org/10.1111/jcmm.14292DOI Listing
April 2019
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Loss of zinc-finger protein 143 contributes to tumour progression by interleukin-8-CXCR axis in colon cancer.

J Cell Mol Med 2019 Apr 1. Epub 2019 Apr 1.

Translational Research Branch, Div. of Translational Science, Goyang, Gyeonggi, South Korea.

Several studies have shown that expression of zinc-finger protein 143 (ZNF143) is closely related to tumour progression including colon cancer. However, it remains unclear how ZNF143 expression is related to tumour progression within the tumour microenvironment. Here, we investigated whether ZNF143 expression affects the tumour microenvironment and tumour progression by screening molecules secreted by colon cancer cells stably expressing short-hairpin RNAs against ZNF143 or control RNAs. Read More

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http://dx.doi.org/10.1111/jcmm.14290DOI Listing
April 2019
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IRF3 and IRF7 mediate neovascularization via inflammatory cytokines.

J Cell Mol Med 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Objective: To elucidate the role of interferon regulatory factor (IRF)3 and IRF7 in neovascularization.

Methods: Unilateral hind limb ischaemia was induced in Irf3 , Irf7 and C57BL/6 mice by ligation of the left common femoral artery. Post-ischaemic blood flow recovery in the paw was measured with laser Doppler perfusion imaging. Read More

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http://dx.doi.org/10.1111/jcmm.14247DOI Listing
April 2019
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BZW2 gene knockdown induces cell growth inhibition, G1 arrest and apoptosis in muscle-invasive bladder cancers: A microarray pathway analysis.

J Cell Mol Med 2019 Apr 1. Epub 2019 Apr 1.

Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Bladder cancer is among the most common cancers all over the world. The function of basic leucine zipper and W2 domains 2 (BZW2) in tumour progression has been reported. However, the biological function of BZW2 in muscle-invasive bladder cancers (MIBCs) remains to be determined. Read More

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http://dx.doi.org/10.1111/jcmm.14266DOI Listing
April 2019
2 Reads

Angiotensin II-induced redox-sensitive SGLT1 and 2 expression promotes high glucose-induced endothelial cell senescence.

J Cell Mol Med 2019 Mar 30. Epub 2019 Mar 30.

UMR CNRS 7213, Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie, Université de Strasbourg, Illkirch, France.

High glucose (HG)-induced endothelial senescence and dysfunction contribute to the increased cardiovascular risk in diabetes. Empagliflozin, a selective sodium glucose co-transporter2 (SGLT2) inhibitor, reduced the risk of cardiovascular mortality in type 2 diabetic patients but the protective mechanism remains unclear. This study examines the role of SGLT2 in HG-induced endothelial senescence and dysfunction. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14233
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http://dx.doi.org/10.1111/jcmm.14233DOI Listing
March 2019
4 Reads

Targeting the ROS/PI3K/AKT/HIF-1α/HK2 axis of breast cancer cells: Combined administration of Polydatin and 2-Deoxy-d-glucose.

J Cell Mol Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.

It is well established that cancer cells depend upon aerobic glycolysis to provide the energy they need to survive and proliferate. However, anti-glycolytic agents have yielded few positive results in human patients, in part due to dose-limiting side effects. Here, we discovered the unexpected anti-cancer efficacy of Polydatin (PD) combined with 2-deoxy-D-glucose (2-DG), which is a compound that inhibits glycolysis. Read More

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http://dx.doi.org/10.1111/jcmm.14276DOI Listing

Vascular progenitor cell senescence in patients with Marfan syndrome.

J Cell Mol Med 2019 Mar 28. Epub 2019 Mar 28.

School of Medicine, South China University of Technology, Guangzhou, China.

Vascular progenitor cells (VPCs) present in the adventitia of the vessel wall play a critical role in the regulation of vascular repair following injury. This study aimed to assess the function of VPCs isolated from patients with Marfan syndrome (MFS). VPCs were isolated from control and MFS donors and characterized. Read More

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http://dx.doi.org/10.1111/jcmm.14301DOI Listing