4,086 results match your criteria Journal of Cellular and Molecular Medicine [Journal]


β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, P.R. China.

We previously reported that nucleotide-binding oligomerization domain-containing protein (NOD) 2 was involved in the inflammatory responses to cerebral ischaemia/reperfusion (I/R) insult. However, the mechanism by which NOD2 participates in brain ischaemic injury and the regulation of NOD2 in the process are still obscure. Increased β-arrestin 2 (ARRB2) expression was observed in microglia following cerebral I/R in wild-type mice besides the up-regulation of NOD2 and TRAF6. Read More

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http://dx.doi.org/10.1111/jcmm.14223DOI Listing
February 2019

Acid-sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

Acidic microenvironment is commonly observed in ischaemic tissue. In the kidney, extracellular pH dropped from 7.4 to 6. Read More

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http://dx.doi.org/10.1111/jcmm.14238DOI Listing
February 2019

Establishment and molecular characterization of decitabine-resistant K562 cells.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Hematology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China.

The clinical activity of decitabine (5-aza-2-deoxycytidine, DAC), a hypomethylating agent, has been demonstrated in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients. However, secondary resistance to this agent often occurs during treatment and leads to treatment failure. It is important to clarify the mechanisms underlying the resistance for improving the efficacy. Read More

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http://dx.doi.org/10.1111/jcmm.14221DOI Listing
February 2019

MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Imaging, Binzhou Medical University, Yantai, China.

Membrane-associated RING-CH-1 (MARCH1) is a membrane-anchored E3 ubiquitin ligase that is involved in a variety of cellular processes. MARCH1 was aberrantly expressed as a tumour promoter in ovarian cancer, but the signalling about the molecular mechanism has not yet been fully illuminated. Here, we first determined that MARCH1 was obviously highly expressed in human hepatocellular carcinoma samples and cells. Read More

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http://dx.doi.org/10.1111/jcmm.14235DOI Listing
February 2019

A novel role of HuR in -Epigallocatechin-3-gallate (EGCG) induces tumour cells apoptosis.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.

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http://dx.doi.org/10.1111/jcmm.14249DOI Listing
February 2019

Inhibition of P53/miR-34a improves diabetic endothelial dysfunction via activation of SIRT1.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Toxicology and Nutrition, School of Public Health, Shandong University, Jinan, Shandong, China.

Endothelial dysfunction contributes to diabetic macrovascular complications, resulting in high mortality. Recent findings demonstrate a pathogenic role of P53 in endothelial dysfunction, encouraging the investigation of the effect of P53 inhibition on diabetic endothelial dysfunction. Thus, high glucose (HG)-treated endothelial cells (ECs) were subjected to pifithrin-α (PFT-α)-a specific inhibitor of P53, or P53-small interfering RNA (siRNA), both of which attenuated the HG-induced endothelial inflammation and oxidative stress. Read More

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http://dx.doi.org/10.1111/jcmm.14253DOI Listing
February 2019

Down-regulated lncRNA SLC25A5-AS1 facilitates cell growth and inhibits apoptosis via miR-19a-3p/PTEN/PI3K/AKT signalling pathway in gastric cancer.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, China.

Mounting evidence has illustrated the vital roles of long non-coding RNAs (lncRNAs in gastric cancer (GC). Nevertheless, the majority of their roles and mechanisms in GC are still largely unknown. In this study, we investigate the roles of lncRNA SLC25A5-AS1 on tumourigenesis and explore its potential mechanisms in GC. Read More

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http://dx.doi.org/10.1111/jcmm.14200DOI Listing
February 2019

IL-35Ig-expressing dendritic cells induce tolerance via Arginase 1.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Experimental Medicine, University of Perugia, Perugia, Italy.

The cytokine interleukin IL-35 is known to exert strong immunosuppressive functions. Indoleamine 2,3-dioxygenase 1 (IDO1) and Arginase 1 (Arg1) are metabolic enzymes that, expressed by dendritic cells (DCs), contribute to immunoregulation. Here, we explored any possible link between IL-35 and the activity of those enzymes. Read More

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http://dx.doi.org/10.1111/jcmm.14215DOI Listing
February 2019

Long non-coding RNA MALAT1 regulates angiogenesis following oxygen-glucose deprivation/reoxygenation.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Long non-coding RNAs (lncRNAs) have been identified as playing critical roles in multiple diseases. However, little is known regarding their roles and mechanisms in post-stroke angiogenesis. Our studies focused on deciphering the functional roles and the underlying mechanisms of the lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the process of angiogenesis following oxygen-glucose deprivation/reoxygenation (OGD/R). Read More

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http://doi.wiley.com/10.1111/jcmm.14204
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http://dx.doi.org/10.1111/jcmm.14204DOI Listing
February 2019
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The pathogenesis of endemic fluorosis: Research progress in the last 5 years.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.

Fluorine is one of the trace elements necessary for health. It has many physiological functions, and participates in normal metabolism. However, fluorine has paradoxical effects on the body. Read More

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http://dx.doi.org/10.1111/jcmm.14185DOI Listing
February 2019

Predicting overall survival of patients with hepatocellular carcinoma using a three-category method based on DNA methylation and machine learning.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Hepatocellular carcinoma (HCC) is closely associated with abnormal DNA methylation. In this study, we analyzed 450K methylation chip data from 377 HCC samples and 50 adjacent normal samples in the TCGA database. We screened 47,099 differentially methylated sites using Cox regression as well as SVM-RFE and FW-SVM algorithms, and constructed a model using three risk categories to predict the overall survival based on 134 methylation sites. Read More

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http://dx.doi.org/10.1111/jcmm.14231DOI Listing
February 2019

Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Diabetic nephropathy (DN) is characterized by inflammation of renal tissue. Glomerular endothelial cells (GEnCs) play an important role in inflammation and protein leakage in urine in DN patients. Chemerin and its receptor ChemR23 are inducers of inflammation. Read More

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http://dx.doi.org/10.1111/jcmm.14237DOI Listing
February 2019

Notch1 activates angiogenic regulator Netrin4 in endothelial cells.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.

Netrin4 (NTN4) is a chemotropic factor that regulates angiogenesis. We found that endothelial expression of the activated, intracellular domain of Notch1 (NICD1), significantly up-regulated NTN4 mRNA as well as intracellular NTN4 protein in both transgenic mice and cultured human umbilical vein endothelial cells (HUVECs). Notch1 activation also increased NTN4 secretion from HUVECs. Read More

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http://dx.doi.org/10.1111/jcmm.14240DOI Listing
February 2019

The role of dendritic cells regulated by HMGB1/TLR4 signalling pathway in myocardial ischaemia reperfusion injury.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Cardiovascular and Thoracic Surgery, Children's Heart Center, The Second Affiliated Hospital & Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, P.R. China.

Inflammatory response plays an important role in ischaemia reperfusion injury (IRI) through a variety of inflammatory cells. Apart from neutrophils, macrophages and lymphocytes, the role of dendritic cells (DCs) in IRI has been noticed. The study was aimed at investigating whether the high-mobility group protein box-1/toll like receptor 4 (HMGB1/TLR4) signalling pathway regulate the migration, adhesion and aggregation of DCs to the myocardium, induce DCs activation and maturation, stimulate the expression of surface costimulatory molecules and participate in myocardial IRI. Read More

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http://dx.doi.org/10.1111/jcmm.14192DOI Listing
February 2019

Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Biomedical Department, Centre Scientifique de Monaco, Monaco, Principality of Monaco.

Most cases of medulloblastoma (MB) occur in young children. While the overall survival rate can be relatively high, current treatments combining surgery, chemo- and radiotherapy are very destructive for patient development and quality of life. Moreover, aggressive forms and recurrences of MB cannot be controlled by classical therapies. Read More

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http://dx.doi.org/10.1111/jcmm.14176DOI Listing
February 2019

MicroRNA-876-5p inhibits cell proliferation, migration and invasion by targeting c-Met in osteosarcoma.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Orthopaedic Surgery, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.

Recently, aberrant expression of miR-876-5p has been reported to participate in the progression of several human cancers. However, the expression and function of miR-876-5p in osteosarcoma (OS) are still unknown. Here, we found that the expression of miR-876-5p was significantly down-regulated in OS tissues compared to para-cancerous tissues. Read More

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http://dx.doi.org/10.1111/jcmm.14217DOI Listing
February 2019

Mesenteric adipose tissue B lymphocytes promote local and hepatic inflammation in non-alcoholic fatty liver disease mice.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Gastroenterology, Peking University People's Hospital, Beijing, P.R. China.

Mesenteric adipose tissue (MAT) inflammation is associated with non-alcoholic fatty liver disease (NAFLD), and immune cells play pivotal roles in the inflammation of adipose tissue. Here, we investigated the roles of MAT B lymphocytes in NAFLD. Mice fed with high-fat diet (HFD) and normal diet (ND) were killed in time gradients (4, 8 and 12 weeks). Read More

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http://dx.doi.org/10.1111/jcmm.14232DOI Listing
February 2019

The latest progress on miR-374 and its functional implications in physiological and pathological processes.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Non-coding RNAs (ncRNAs) have been emerging players in cell development, differentiation, proliferation and apoptosis. Based on their differences in length and structure, they are subdivided into several categories including long non-coding RNAs (lncRNAs >200nt), stable non-coding RNAs (60-300nt), microRNAs (miRs or miRNAs, 18-24nt), circular RNAs, piwi-interacting RNAs (26-31nt) and small interfering RNAs (about 21nt). Therein, miRNAs not only directly regulate gene expression through pairing of nucleotide bases between the miRNA sequence and a specific mRNA that leads to the translational repression or degradation of the target mRNA, but also indirectly affect the function of downstream genes through interactions with lncRNAs and circRNAs. Read More

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http://dx.doi.org/10.1111/jcmm.14219DOI Listing
February 2019

Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Central Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Peripheral nerve injury results in limited nerve regeneration and severe functional impairment. Mesenchymal stem cells (MSCs) are a remarkable tool for peripheral nerve regeneration. The involvement of human umbilical cord MSC-derived extracellular vesicles (hUCMSC-EVs) in peripheral nerve regeneration, however, remains unknown. Read More

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http://dx.doi.org/10.1111/jcmm.14190DOI Listing
February 2019

Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post-menopausal women with severe pelvic organ prolapse.

J Cell Mol Med 2019 Feb 17. Epub 2019 Feb 17.

Department of Physiology, University of Toronto, Toronto, ON, Canada.

This study investigates the effect of local oestrogen therapy (LET) on the expression of proteins participating in collagen/elastin biogenesis and immune markers in vaginal tissues of post-menopausal women with severe pelvic organ prolapse (POP). Vaginal biopsies were collected from the anterior vaginal wall of informed and consented 52 post-menopausal women with severe POP undergoing total hysterectomy. Twenty-nine of the 52 women were treated with LET (in the form of vaginal oestrogen cream or tablet), while the remaining 23 untreated patients served as the controls. Read More

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http://dx.doi.org/10.1111/jcmm.14199DOI Listing
February 2019
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Ligustilide attenuates nitric oxide-induced apoptosis in rat chondrocytes and cartilage degradation via inhibiting JNK and p38 MAPK pathways.

J Cell Mol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Orthopedics, Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

Ligustilide (LIG) is the main lipophilic component of the Umbelliferae family of pharmaceutical plants, including Radix angelicae sinensis and Ligusticum chuanxiong. LIG shows various pharmacological properties associated with anti-inflammation and anti-apoptosis in several kinds of cell lines. However, the therapeutic effects of LIG on chondrocyte apoptosis remain unknown. Read More

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http://dx.doi.org/10.1111/jcmm.14226DOI Listing
February 2019
2 Reads

LEF1-AS1, long non-coding RNA, inhibits proliferation in myeloid malignancy.

J Cell Mol Med 2019 Feb 15. Epub 2019 Feb 15.

Hematology and Hemotherapy Center, Hemocentro-Unicamp, São Paulo, Brazil.

LEF1 antisense RNA 1 (LEF1-AS1) is an antisense long non-coding RNA encoded in the lymphoid enhancer-binding factor 1 (LEF1) locus. LEF1-AS1 is a conserved transcript dysregulated in hematopoiesis. This study aimed to functionally characterize the role of this transcript in myeloid malignancy and explore a possible regulatory effect of LEF1-AS1 upon LEF1. Read More

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http://dx.doi.org/10.1111/jcmm.14152DOI Listing
February 2019
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Matrine attenuates high-fat diet-induced in vivo and ox-LDL-induced in vitro vascular injury by regulating the PKCα/eNOS and PI3K/Akt/eNOS pathways.

J Cell Mol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.

Lipid metabolism disorders lead to vascular endothelial injury. Matrine is an alkaloid that has been used to improve obesity and diabetes and for the treatment of hepatitis B. However, its effect on lipid metabolism disorders and vascular injury is unclear. Read More

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http://dx.doi.org/10.1111/jcmm.14180DOI Listing
February 2019
2 Reads

CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF-κB signalling pathway.

J Cell Mol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Metastasis is one of the primary causes for high mortality in patients with squamous cell carcinoma of the head and neck (SCCHN). Our previous study showed that chemokine (C-C motif) ligand 18 (CCL18), derived from tumour-associated macrophages (TAMs), regulates SCCHN metastasis by promoting epithelial-mesenchymal transition (EMT) and preserving stemness. However, the underlying mechanism needs to be further investigation. Read More

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http://dx.doi.org/10.1111/jcmm.14168DOI Listing
February 2019

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.

J Cell Mol Med 2019 Feb 14. Epub 2019 Feb 14.

Department of General Surgery, The Second People's Hospital of Guangdong Province, Southern Medical University, Guangzhou, Guangdong, P.R.China.

In this study, microarray data analysis, real-time quantitative PCR and immunohistochemistry were used to detect the expression levels of SSRP1 in colorectal cancer (CRC) tissue and in corresponding normal tissue. The association between structure-specific recognition protein 1 (SSRP1) expression and patient prognosis was examined by Kaplan-Meier analysis. SSRP1 was knocked down and overexpressed in CRC cell lines, and its effects on proliferation, cell cycling, migration, invasion, cellular energy metabolism, apoptosis, chemotherapeutic drug sensitivity and cell phenotype-related molecules were assessed. Read More

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http://doi.wiley.com/10.1111/jcmm.14134
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http://dx.doi.org/10.1111/jcmm.14134DOI Listing
February 2019
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Mutant hFGF23(A12D) stimulates osteoblast differentiation through FGFR3.

J Cell Mol Med 2019 Feb 13. Epub 2019 Feb 13.

Laboratory of Oral Biomedical Science and Translational Medicine, School and Hospital of Stomatology, Tongji University, Shanghai, China.

Fibroblast growth factor (FGF) 23 is a member of the FGF family involved in bone development by interacting with FGFRs. In a previous study, we discovered a mutant human FGF (hFGF) 23 (A12D) in the mandibular prognathism (MP) pedigree. However, the exact role of hFGF23(A12D) during bone formation remains unclear. Read More

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http://dx.doi.org/10.1111/jcmm.14201DOI Listing
February 2019

EIF5A regulates proliferation and chemoresistance in pancreatic cancer through the sHH signalling pathway.

J Cell Mol Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Background: Pancreatic cancer (PC) has a very poor prognosis and comparatively short survival. Eukaryotic translation initiation factor 5A (EIF5A) promotes cancer metastasis. Here, we exploited the biological role of EIF5A in PC chemoresistance. Read More

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http://doi.wiley.com/10.1111/jcmm.14167
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http://dx.doi.org/10.1111/jcmm.14167DOI Listing
February 2019
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PECAM-1 modulates liver damage induced by synergistic effects of TNF-α and irradiation.

J Cell Mol Med 2019 Feb 14. Epub 2019 Feb 14.

Clinic for Gastroenterology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.

The mechanisms of radiation-induced liver damage are poorly understood. We investigated if tumour necrosis factor (TNF)-α acts synergistically with irradiation, and how its activity is influenced by platelet endothelial cell adhesion molecule-1 (PECAM-1). We studied murine models of selective single-dose (25 Gy) liver irradiation with and without TNF-α application (2 μg/mouse; i. Read More

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http://dx.doi.org/10.1111/jcmm.14224DOI Listing
February 2019

miR-181c-5p mediates simulated microgravity-induced impaired osteoblast proliferation by promoting cell cycle arrested in the G phase.

J Cell Mol Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Orthopedics, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Impaired osteoblast proliferation plays fundamental roles in microgravity-induced bone loss, and cell cycle imbalance may result in abnormal osteoblast proliferation. However, whether microgravity exerts an influence on the cell cycle in osteoblasts or what mechanisms may underlie such an effect remains to be fully elucidated. Herein, we confirmed that simulated microgravity inhibits osteoblast proliferation. Read More

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http://dx.doi.org/10.1111/jcmm.14220DOI Listing
February 2019
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Identification of dysregulation of atrial proteins in rats with chronic obstructive apnea using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry.

J Cell Mol Med 2019 Feb 12. Epub 2019 Feb 12.

Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, New York.

Obstructive sleep apnea (OSA) affects an estimated 20% of adults worldwide and has been associated with electrical and structural abnormalities of the atria, although the molecular mechanisms are not well understood. Here, we used two-dimensional polyacrylamide gel electrophoresis (2D PAGE) coupled with nanoliquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) to investigate the proteins that are dysregulated in the atria from severe and moderate apnea when compared to control. We found enzymes involved in the glycolysis, beta-oxidation, electron transport chain and Krebs cycle to be down-regulated. Read More

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http://dx.doi.org/10.1111/jcmm.14131DOI Listing
February 2019
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Role of mitochondrial calcium uniporter-mediated Ca and iron accumulation in traumatic brain injury.

J Cell Mol Med 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu Province, China.

Previous studies have suggested that the cellular Ca and iron homeostasis, which can be regulated by mitochondrial calcium uniporter (MCU), is associated with oxidative stress, apoptosis and many neurological diseases. However, little is known about the role of MCU-mediated Ca and iron accumulation in traumatic brain injury (TBI). Under physiological conditions, MCU can be inhibited by ruthenium red (RR) and activated by spermine (Sper). Read More

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http://dx.doi.org/10.1111/jcmm.14206DOI Listing
February 2019

Endoplasmic reticulum stress-dependent autophagy inhibits glycated high-density lipoprotein-induced macrophage apoptosis by inhibiting CHOP pathway.

J Cell Mol Med 2019 Feb 12. Epub 2019 Feb 12.

Key Laboratory of Atherosclerosis in Universities of Shandong and Institute of Atherosclerosis, Taishan Medical University, Taian, China.

This study was designed to explore the inductive effect of glycated high-density lipoprotein (gly-HDL) on endoplasmic reticulum (ER) stress-C/EBP homologous protein (CHOP)-mediated macrophage apoptosis and its relationship with autophagy. Our results showed that gly-HDL caused macrophage apoptosis with concomitant activation of ER stress pathway, including nuclear translocation of activating transcription factor 6, phosphorylation of protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2α, and CHOP up-regulation, which were inhibited by 4-phenylbutyric acid (PBA, an ER stress inhibitor) and the gene silencing of PERK and CHOP. Similar data were obtained from macrophages treated by HDL isolated from diabetic patients. Read More

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http://doi.wiley.com/10.1111/jcmm.14203
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http://dx.doi.org/10.1111/jcmm.14203DOI Listing
February 2019
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HnRNPL inhibits the osteogenic differentiation of PDLCs stimulated by SrCl through repressing Setd2.

J Cell Mol Med 2019 Feb 12. Epub 2019 Feb 12.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan University, Wuhan, People's Republic of China.

Osteoporosis has been shown to intensify bone loss caused by periodontitis and both share common risk factors. One strategy utilized to manage the disease has been via the release of Sr ions by Strontium Ranelate having a direct effect on preventing osteoclast activation and promoting osteoblast differentiation. Previously we have developed and characterized porous Sr-mesoporous bioactive glass (Sr-MBG) scaffolds and demonstrated their ability to promote periodontal regeneration when compared to MBG alone. Read More

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http://dx.doi.org/10.1111/jcmm.14166DOI Listing
February 2019
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Inhibition of PAI-1 limits chemotherapy resistance in lung cancer through suppressing myofibroblast characteristics of cancer-associated fibroblasts.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Respiratory Internal Medicine, Hiroshima University Hospital, Hiroshima, Japan.

Plasminogen activator inhibitor-1 (PAI-1) promotes pulmonary fibrosis through increasing myofibroblast (MF) characteristics, expressing alpha-smooth muscle actin (α-SMA) in fibroblasts. Fibroblasts in the tumour stroma are called cancer-associated fibroblasts (CAFs). Some CAFs have MF characteristics and substantially promote tumour progression and chemotherapy resistance. Read More

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http://dx.doi.org/10.1111/jcmm.14205DOI Listing
February 2019

Critical role of Lin28-TNFR2 signalling in cardiac stem cell activation and differentiation.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Yale Stem Center, Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Tumour necrotic factor receptor-2 (TNFR2) has been to be cardiac-protective and is expressed in cardiac progenitor cells. Our goal is to define the mechanism for TNFR2-mediated cardiac stem cell activation and differentiation. By employing a protocol of in vitro cardiac stem cell (CSC) differentiation from human inducible pluripotent stem cell (hiPSC), we show that expression of TNFR2 precedes expression of CSC markers followed by expression of mature cardiomyocyte proteins. Read More

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http://doi.wiley.com/10.1111/jcmm.14202
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http://dx.doi.org/10.1111/jcmm.14202DOI Listing
February 2019
2 Reads

Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurosurgery, Second Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou City, Zhejiang Province, China.

Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia as an independent risk factor for the development of emerging or recurrent depression among young, middle-aged and older adults. This bidirectional association between sleep disturbance and depression has created a new perspective that sleep problems are no longer an epiphenomenon of depression but a predictive prodromal symptom. Read More

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http://dx.doi.org/10.1111/jcmm.14170DOI Listing
February 2019
1 Read

MicroRNA-1258, regulated by c-Myb, inhibits growth and epithelial-to-mesenchymal transition phenotype via targeting SP1 in oral squamous cell carcinoma.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Thyroid and Breast Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

The biological function and underlying mechanism of miR-1258 has seldom been investigated in cancer progression, including in oral squamous cell carcinoma (OSCC). In the current study, we revealed that the expression level of miR-1258 was significantly down-regulated in OSCC tissues and cell lines. Restoration of miR-1258 decreased OSCC cell growth and invasion. Read More

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http://dx.doi.org/10.1111/jcmm.14189DOI Listing
February 2019

Histone deacetylase inhibitor LMK235 attenuates vascular constriction and aortic remodelling in hypertension.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Heart Research Center of Chonnam National University Hospital, Gwangju, Republic of Korea.

Here, we report that LMK235, a class I and histone deacetylase (HDAC6)-preferential HDAC inhibitor, reduces hypertension via inhibition of vascular contraction and vessel hypertrophy. Angiotensin II-infusion mice and spontaneously hypertensive rats (SHRs) were used to test the anti-hypertensive effect of LMK235. Daily injection of LMK235 lowered angiotensin II-induced systolic blood pressure (BP). Read More

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http://dx.doi.org/10.1111/jcmm.14188DOI Listing
February 2019

Circulating RNAs as predictive markers for the progression of type 2 diabetes.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Institute for Systems Biology, Seattle, Washington.

Type 2 Diabetes Mellitus (T2DM) is the most prevalent form of diabetes in the USA, thus, the identification of biomarkers that could be used to predict the progression from prediabetes to T2DM would be greatly beneficial. Recently, circulating RNA including microRNAs (miRNAs) present in various body fluids have emerged as potential biomarkers for various health conditions, including T2DM. Whereas studies that examine the changes of miRNA spectra between healthy controls and T2DM individuals have been reported, the goal of this study is to conduct a baseline comparison of prediabetic individuals who either progress to T2DM, or remain prediabetic. Read More

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http://dx.doi.org/10.1111/jcmm.14182DOI Listing
February 2019
1 Read

Cardioprotective effect of MMP-2-inhibitor-NO-donor hybrid against ischaemia/reperfusion injury.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry, Wroclaw Medical University, Wroclaw, Poland.

Hypoxic injury of cardiovascular system is one of the most frequent complications following ischaemia. Heart injury arises from increased degradation of contractile proteins, such as myosin light chains (MLCs) and troponin I by matrix metalloproteinase 2 (MMP-2). The aim of the current research was to study the effects of 5-phenyloxyphenyl-5-aminoalkyl nitrate barbiturate (MMP-2-inhibitor-NO-donor hybrid) on hearts subjected to ischaemia/reperfusion (I/R) injury. Read More

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http://dx.doi.org/10.1111/jcmm.14191DOI Listing
February 2019

Chondroprotection of PPARα activation by WY14643 via autophagy involving Akt and ERK in LPS-treated mouse chondrocytes and osteoarthritis model.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.

Autophagy maintains cellular homoeostasis. The enhancement of autophagy in chondrocytes could prevent osteoarthritis (OA) progression in articular cartilage. Peroxisome proliferator-activated receptor α (PPARα) activation may also protect articular chondrocytes against cartilage degradation in OA. Read More

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http://dx.doi.org/10.1111/jcmm.14184DOI Listing
February 2019
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MicroRNA-488 inhibits endometrial glandular epithelial cell proliferation, migration, and invasion in endometriosis mice via Wnt by inhibiting FZD7.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Reproductive Health, Nanjing Maternity and Child Health Care Hospital, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing, P. R. China.

Endometriosis is a chronic inflammatory syndrome and nearly 6%-10% of women are affected by it during the reproductive period. Previous studies have proved that microRNAs (miRNAs) are implicated in the pathogenesis of ovarian endometriosis. In this study, we aimed to investigate that restored miR-488 would effectively inhibit the development of endometriosis. Read More

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http://dx.doi.org/10.1111/jcmm.14078DOI Listing
February 2019
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In memoriam: Francisc Schneider (1933-2017).

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Internal Medicine, UNM School of Medicine, Albuquerque, New Mexico.

This is the obituary for Francisc Schneider, who introduced clinical physiology in Romania and mentored generations of scientists. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14173
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http://dx.doi.org/10.1111/jcmm.14173DOI Listing
February 2019
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MicroRNA-205 is associated with diabetes mellitus-induced erectile dysfunction via down-regulating the androgen receptor.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Urology, China-Japan Union Hospital of Jilin University, Changchun, China.

As a major class of regulatory genes in majority metazoans, microRNAs (miRs) play an important role in various diseases including diabetes mellitus (DM). Lack of androgens has previously been associated with DM-induced erectile dysfunction (DMED). In addition, the biological functioning of androgen is mediated by androgen receptor (AR). Read More

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http://dx.doi.org/10.1111/jcmm.14212DOI Listing
February 2019
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Development of a risk scoring system for patients with papillary thyroid cancer.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.

As the importance of personalized therapeutics in aggressive papillary thyroid cancer (PTC) increases, accurate risk stratification is required. To develop a novel prognostic scoring system for patients with PTC (n = 455), we used mRNA expression and clinical data from The Cancer Genome Atlas. We performed variable selection using Network-Regularized high-dimensional Cox-regression with gene network from pathway databases. Read More

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http://dx.doi.org/10.1111/jcmm.14208DOI Listing
February 2019

Genetically elevated circulating homocysteine concentrations increase the risk of diabetic kidney disease in Chinese diabetic patients.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

BioBank Center, China-Japan Friendship Hospital, Institute of Clinical Medical Science, Beijing, China.

Diabetic kidney disease (DKD) is a devastating and frequent complication of diabetes mellitus. Here, we first adopted methylenetetrahytrofolate reductase (MTHFR) gene C677T polymorphism as an instrument to infer the possible causal relevance between circulating homocysteine and DKD risk in a Chinese population and next attempted to build a risk prediction model for DKD. This is a hospital-based case-control association study. Read More

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http://dx.doi.org/10.1111/jcmm.14187DOI Listing
February 2019
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MiR-802 causes nephropathy by suppressing NF-κB-repressing factor in obese mice and human.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Wenzhou, China.

Obesity is associated with significant microvascular complications including renal injuries and may induce end-stage renal disease. Emerging studies have demonstrated microRNAs (miRNAs) are potential mediators in the pathophysiological process of nephropathy. The present study aimed to investigate the role of miR-802 in obesity-related nephropathy and potential molecular mechanisms. Read More

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http://dx.doi.org/10.1111/jcmm.14193DOI Listing
February 2019
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The Pros1/Tyro3 axis protects against periodontitis by modulating STAT/SOCS signalling.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Department of Stomatology, Changzheng Hospital, Second Military Medical University, Shanghai, P. R. China.

Periodontitis, an oral inflammatory disease caused by periodontal pathogen infection, is the most prevalent chronic inflammatory disease and a major burden on healthcare. The TAM receptor tyrosine kinases (Tyro3, Axl and Mertk) and their ligands (Gas6 and Pros1) play a pivotal role in the resolution of inflammation and have been associated with chronic inflammatory and autoimmune diseases. In this study, we evaluated the effects of exogenous Pros1 in in vitro and in vivo models of periodontitis. Read More

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http://dx.doi.org/10.1111/jcmm.14183DOI Listing
February 2019

Serum semaphorin 7A is associated with the risk of acute atherothrombotic stroke.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Cyrus Tang Medical Institute, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu, China.

Semaphorin 7A (Sema7A), a neural guidance cue, was recently identified to regulate atherosclerosis in mice. However, the clinical relevance of Sema7A with atherosclerotic diseases remains unknown. The aim of this study was to investigate the association between serum Sema7A and the risk of acute atherothrombotic stroke (AAS). Read More

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http://dx.doi.org/10.1111/jcmm.14186DOI Listing
February 2019

Novel role of the clustered miR-23b-3p and miR-27b-3p in enhanced expression of fibrosis-associated genes by targeting TGFBR3 in atrial fibroblasts.

J Cell Mol Med 2019 Feb 7. Epub 2019 Feb 7.

Guangdong Provincial Key Laboratory of Clinical Pharmacology, Guangdong Cardiovascular Institute, Guangzhou, China.

Atrial fibrillation (AF) is the most common type of arrhythmia in cardiovascular diseases. Atrial fibrosis is an important pathophysiological contributor to AF. This study aimed to investigate the role of the clustered miR-23b-3p and miR-27b-3p in atrial fibrosis. Read More

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http://dx.doi.org/10.1111/jcmm.14211DOI Listing
February 2019
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