14,646 results match your criteria Journal of Cellular Physiology[Journal]


Investigating the expression and promoter methylation of RET gene in patients with medullary thyroid cancer with unmutated RET.

J Cell Physiol 2019 Mar 14. Epub 2019 Mar 14.

Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: Thyroid cancer is one of the most common endocrine malignancies. Mutations in the rearranged during transfection (RET) gene, especially in exon 10, 11, and 16, as well as epigenetic modifications, constitute the major underlying molecular events leading to medullary thyroid cancer (MTC). There are few studies on the mutations and epigenetic changes of RET gene in Iranian patients with MTC. Read More

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http://dx.doi.org/10.1002/jcp.28295DOI Listing

Role of microRNA-145 in protection against myocardial ischemia/reperfusion injury in mice by regulating expression of GZMK with the treatment of sevoflurane.

J Cell Physiol 2019 Mar 14. Epub 2019 Mar 14.

Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.

This study aims to investigate the role of microRNA-145 (miR-145) in protection against myocardial ischemia/reperfusion (I/R) injury in mice by regulating expression of granzyme K (GZMK) with the treatment of sevoflurane. The mice model of myocardial I/R injury was established by left coronary artery ligation. The expression of miR-145 and GZMK in myocardial tissues of mice was detected by Reverse transcription quantitative polymerase chain reaction and western blot analysis. Read More

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http://dx.doi.org/10.1002/jcp.28323DOI Listing

Transient upregulation of TASK-1 expression in the hypoglossal nucleus during chronic intermittent hypoxia is reduced by serotonin 2A receptor antagonist.

J Cell Physiol 2019 Mar 12. Epub 2019 Mar 12.

Institute of Respiratory Disease, The First Hospital of China Medical University, Shenyang, Liaoning, China.

Hypoglossal motoneurons innervate genioglossus muscle, the contraction of which is critical in the maintenance of upper airway patency in patients with obstructive sleep apnea. As a potassium channel distributed in hypoglossal motoneurons, TWIK-related acid-sensitive K+ channel-1 (TASK-1) could be inhibited by 5-HT. This study aimed to investigate if TASK-1 expression in hypoglossal nucleus could be influenced by chronic intermittent hypoxia (CIH) and 5-HT receptors antagonist. Read More

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http://dx.doi.org/10.1002/jcp.28419DOI Listing

Flip-flops of natural killer cells in autoimmune diseases versus cancers: Immunologic axis.

J Cell Physiol 2019 Mar 12. Epub 2019 Mar 12.

Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Natural killer (NK) cells play an essential role in the immune response to infections, inflammations, and malignancies. Recent studies suggest that NK cell surface receptors and cytokines are the key points of the disease development and protection. We hypothesized that the interactions between NK cell receptors and targeted cells construct an eventual niche, and this niche has an eventual profile in various autoimmune diseases and cancers. Read More

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http://dx.doi.org/10.1002/jcp.28421DOI Listing

Downregulation of circDYNC1H1 exhibits inhibitor effect on cell proliferation and migration in hepatocellular carcinoma through miR-140-5p.

J Cell Physiol 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Circular RNAs have been found to be aberrantly expressed in tumors and their significance in tumorigenesis has been focused on. The role of circDYNC1H1 in hepatocellular carcinoma (HCC) pathogenesis and its relationship with miR-140-5p were explored. The expression of circDYNC1H1, miR-140-5p, and SULT2B1 in HCC tissues and cells was measured, and Pearson's analysis was used to analyze their expression correlation. Read More

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http://doi.wiley.com/10.1002/jcp.28403
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http://dx.doi.org/10.1002/jcp.28403DOI Listing
March 2019
2 Reads

RA promotes proliferation of primordial germ cell-like cells differentiated from porcine skin-derived stem cells.

J Cell Physiol 2019 Mar 11. Epub 2019 Mar 11.

College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, China.

Previous studies have shown that primordial germ cell-like cells (PGCLCs) can be obtained from human, porcine and mouse skin-derived stem cells (SDSCs). In this paper, we found retinoic acid (RA), the active derivative of vitamin A, accelerated the growth of porcine primordial germ cells (pPGCs) and porcine PGCLCs (pPGCLCs) which were derived from porcine SDSCs (pSDSCs). Moreover, flow cytometry results revealed that the proliferation promoting effect of RA was attenuated by U0126, a specific inhibitor of extracellular signal-regulated kinase (ERK). Read More

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http://doi.wiley.com/10.1002/jcp.28454
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http://dx.doi.org/10.1002/jcp.28454DOI Listing
March 2019
1 Read
3.839 Impact Factor

Melatonin-mediated regulation of autophagy: Making sense of double-edged sword in cancer.

J Cell Physiol 2019 Mar 11. Epub 2019 Mar 11.

Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Much research has been conducted to discover novel techniques to reverse the process of tumorigenesis and, cure already stablished malignancies. One well-stablished approach has been the use of organic compounds and naturally found agents such as melatonin whose anticancer effects have been shown in multiple studies, signaling a unique opportunity regarding cancer prevention and treatment. Various agents use a variety of methods to exert their anticancer effects. Read More

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http://doi.wiley.com/10.1002/jcp.28435
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http://dx.doi.org/10.1002/jcp.28435DOI Listing
March 2019
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Hypermethylated and downregulated MEIS2 are involved in stemness properties and oxaliplatin-based chemotherapy resistance of colorectal cancer.

J Cell Physiol 2019 Mar 11. Epub 2019 Mar 11.

Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, China.

The resistance against oxaliplatin (L-OHP) based regimens remains a major obstacle for its efficient usage in treating metastatic colorectal cancer (mCRC). In this study, we performed weighted gene coexpression network analysis (WGCNA) to systematically screen the relevant hub genes for L-OHP resistance using the raw microarray data of 30 consecutive mCRC samples from our earlier study (GSE69657). The results were further confirmed through datasets from Gene Expression Omnibus (GEO). Read More

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http://dx.doi.org/10.1002/jcp.28451DOI Listing
March 2019
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microRNA-203 promotes proliferation, differentiation, and migration of osteoblasts by upregulation of Msh homeobox 2.

J Cell Physiol 2019 Mar 10. Epub 2019 Mar 10.

Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Despite the improvements in fracture healing, about 10% of patients undergo abnormal healing. As a tumor suppressor, upregulation of microRNA (miR)-203 has been observed in osteogenic differentiation. Herein, we aimed to explore the functional role of miR-203 in osteoblasts as well as the underlying mechanisms. Read More

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http://dx.doi.org/10.1002/jcp.28387DOI Listing

Scavenger receptor Class B type I as a potential risk stratification biomarker and therapeutic target in cardiovascular disease.

J Cell Physiol 2019 Mar 10. Epub 2019 Mar 10.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Cardiovascular disease (CVD) is the leading cause of mortality globally. There are few useful markers available for CVD risk stratification that has proven clinical utility. Scavenger receptor B type I (SR-BI) is a cell surface protein that plays a major role in cholesterol homeostasis through its interaction with high-density lipoprotein-cholesterol (HDL-C) esters (CE). Read More

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http://doi.wiley.com/10.1002/jcp.28393
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http://dx.doi.org/10.1002/jcp.28393DOI Listing
March 2019
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Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model.

J Cell Physiol 2019 Mar 10. Epub 2019 Mar 10.

Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implants, Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

Apoptosis of chondrocytes are the main initiator of osteoarthritis (OA) and can be explained by oxidative stress and endoplasmic reticulum (ER) stress, thus the pharmacological interventions aimed at inhibiting of these pathways may be a promising approach for the management of OA. Quercetin is a member of the flavonoid family and has antioxidant and anti-inflammatory properties in degenerative diseases. However, its effects and potential mechanisms on the pathological process of OA are not very clear. Read More

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http://doi.wiley.com/10.1002/jcp.28452
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http://dx.doi.org/10.1002/jcp.28452DOI Listing
March 2019
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Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways.

J Cell Physiol 2019 Mar 10. Epub 2019 Mar 10.

Department of Trauma Orthopedic and Hand Surgery, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Prosthesis loosening is a highly troublesome clinical problem following total joint arthroplasty. Wear-particle-induced osteoclastogenesis has been shown to be the primary cause of periprosthetic osteolysis that eventually leads to aseptic prosthesis loosening. Therefore, inhibiting osteoclastogenesis is a promising strategy to control periprosthetic osteolysis. Read More

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http://dx.doi.org/10.1002/jcp.28384DOI Listing

Novel trastuzumab-DM1 conjugate: Synthesis and bio-evaluation.

J Cell Physiol 2019 Mar 10. Epub 2019 Mar 10.

Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

Antibody-drug conjugates are now of considerable interest and are recommended for the treatment of cancers. Linkers are having a crucial role in potency and efficacy of these drugs. Herein, for the first time, we have used a water-soluble poly-ethylene glycol based linker (succinimidyl-[(N-maleimido propionamido)-diethyleneglycol] [SM(PEG)2]) for lysine amide coupling of DM1 drug to trastuzumab considering evaluation of the effect of using a hydrophilic linker on physicochemical and biological properties of the resulting conjugate in comparison to the conjugate containing succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC) linker, which has a relative hydrophobic nature. Read More

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http://dx.doi.org/10.1002/jcp.28453DOI Listing

Conditioned media from adipocytes promote proliferation, migration, and invasion in melanoma and colorectal cancer cells.

J Cell Physiol 2019 Mar 9. Epub 2019 Mar 9.

Department of Korean Pathology, College of Korean Medicine, Kyung Hee University, Kyungheedae-ro, Dongdaemun-gu, Seoul, Republic of Korea.

Epidemiological evidence suggests that obesity can significantly increase the risk of various cancers, although the mechanisms underlying this link are completely unknown. Here, we analyzed the effect of adipocytes on melanoma and colon cancer cells proliferation, migration, and invasion. The potential effects of conditioned media (CM) obtained from differentiated mouse 3T3-L1 cells and human adipose tissue-derived mesenchymal stem cells (hAMSC) on the proliferation, migration, and invasion of B16BL6 melanoma and colon 26-L5 cancer cells were investigated. Read More

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http://dx.doi.org/10.1002/jcp.28456DOI Listing

Reduced lung cancer burden by selective immunomodulators elicits improvements in muscle proteolysis and strength in cachectic mice.

J Cell Physiol 2019 Mar 9. Epub 2019 Mar 9.

Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer, Health and Experimental Sciences Department (CEXS), MIM-Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra, Barcelona, Spain.

Identification of to what extent tumor burden influences muscle mass independently of specific treatments for cancer-cachexia remains to be elucidated. We hypothesized that reduced tumor burden by selective treatment of tumor with immunomodulators may exert beneficial effects on muscle wasting and function in mice. Body and muscle weight, grip strength, physical activity, muscle morphometry, apoptotic nuclei, troponin-I systemic levels, interleukin-6, proteolytic markers, and tyrosine release, and apoptosis markers were determined in diaphragm and gastrocnemius muscles of lung cancer (LP07 adenocarcinoma cells) mice (BALB/c) treated with monoclonal antibodies (mAbs), against immune check-points and pathways (CD-137, cytotoxic T-lymphocyte associated protein-4, programed cell death-1, and CD-19; N = 10/group). Read More

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http://dx.doi.org/10.1002/jcp.28437DOI Listing
March 2019
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Comparison of osteogenic differentiation potential of induced pluripotent stem cells on 2D and 3D polyvinylidene fluoride scaffolds.

J Cell Physiol 2019 Mar 9. Epub 2019 Mar 9.

Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

In recent decades, tissue engineering has been the most contributor for introducing 2D and 3D biocompatible osteoinductive scaffolds as bone implants. Polyvinylidene fluoride (PVDF), due to the unique mechanical strength and piezoelectric properties, can be a good choice for making a bone bioimplant. In the present study, PVDF nanofibers and film were fabricated as 3D and 2D scaffolds, and then, osteogenic differentiation potential of the human induced pluripotent stem cells (iPSCs) was investigated when grown on the scaffolds by evaluating the common osteogenic markers in comparison with tissue culture plate. Read More

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http://dx.doi.org/10.1002/jcp.28415DOI Listing
March 2019
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Crocin inhibits the migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells via miR-320/KLF5/HIF-1α signaling.

J Cell Physiol 2019 Mar 9. Epub 2019 Mar 9.

Department of Gastroenterology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.

The biological activities of crocin, one of the main bioactive compounds of saffron, include anti-inflammatory, antioxidant, antidepressant, and anticancer effects. Crocin has been shown to trigger the apoptosis of gastric cancer cells, but its effect on the metastasis of gastric cancer cells remains unclear. Krüppel-like factor 5 (KLF5) and hypoxia-inducible factor-1α (HIF-1α) are important transcription factors in the development of gastric cancer. Read More

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http://dx.doi.org/10.1002/jcp.28418DOI Listing

Prognostic significance of X-linked inhibitor of apoptosis protein in solid tumors: A systematic review and meta-analysis.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Department of Clinical Laboratory, Jilin University China-Japan Union Hospital, Changchun, Jilin, China.

X-linked inhibitor of apoptosis protein (XIAP) is aberrantly expressed in solid tumors. Considering conflicting data, we conducted this meta-analysis to investigate its prognostic role. Electronic databases were searched to collect studies about associations between XIAP expressions and survival outcomes. Read More

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http://dx.doi.org/10.1002/jcp.28443DOI Listing

ELP2 negatively regulates osteoblastic differentiation impaired by tumor necrosis factor α in MC3T3-E1 cells through STAT3 activation.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Department of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People's Republic of China.

Tumor necrosis factor-α (TNF-α) is a pluripotent signaling molecule. The biological effect of TNF-α includes slowing down osteogenic differentiation, which can lead to bone dysplasia in long-term inflammatory microenvironments. Signal transducer and activator of transcription 3 (STAT3)-interacting protein 1 (StIP1, also known as elongator complex protein 2, ELP2) play a role in inhibiting TNF-α-induced osteoblast differentiation. Read More

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http://dx.doi.org/10.1002/jcp.28440DOI Listing
March 2019
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Signaling roadmap to epithelial-mesenchymal transition in pterygium, TWIST1 centralized.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Pterygium as a complex disease shares common features with other malignant cells in its onset recurrence and especially epithelial-mesenchymal transition (EMT) transition. Although using different approaches including conjunctival autografts, amniotic membrane, radiotherapy, mitomycin C (MMC) has shown promising insights in the inhibition of pterygium recurrence, it needs to be investigated in more details in molecular pathways to present adjuvant target therapy. In this study, we aimed to evaluate the expression of and then illustrate the role of signaling pathways on EMT in pterygium. Read More

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http://dx.doi.org/10.1002/jcp.28447DOI Listing
March 2019
2 Reads

The impact of curcumin and its modified formulations on Alzheimer's disease.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.

Alzheimer's disease (AD) is a major health problem worldwide, with no effective treatment approach. Curcumin is the main ingredient of turmeric traditionally used in Asian medicine. Several experimental studies have indicated the protective effect of curcumin and its novel formulations in AD. Read More

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http://dx.doi.org/10.1002/jcp.28411DOI Listing
March 2019
2 Reads
3.839 Impact Factor

Ski-related novel protein suppresses the development of diabetic nephropathy by modulating transforming growth factor-β signaling and microRNA-21 expression.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Department of Pathophysiology, Guizhou Medical University, Guiyang, China.

Unveiling the mechanisms that drive the pathological phenotypes of diabetic nephropathy (DN) could help develop new effective therapeutics for this ailment. Transforming growth factor-β1 (TGF-β1)/Smad3 signaling is aberrantly induced in DN, leading to elevated microRNA-21 (miR-21) expression and tissue fibrosis. Ski-related novel protein (SnoN) negatively regulates the TGF-β pathway, but the relationship between SnoN and miR-21 has not been described in the context of DN. Read More

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http://doi.wiley.com/10.1002/jcp.28425
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http://dx.doi.org/10.1002/jcp.28425DOI Listing
March 2019
4 Reads

Genome-wide analysis reveals miR-3184-5p and miR-181c-3p as a critical regulator for adipocytes-associated breast cancer.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru, India.

Obesity is considered as an independent risk factor for breast cancer (BCa) and plays a major role in the breast tumor microenvironment. The etiology and mechanisms by which obesity contributes to BCa development is not yet understood. Herein, we show that in vitro coculture of BCa cells with mature adipocytes (MA-BCa) increased proliferation, migration, and invasive phenotype of BCa cells. Read More

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http://dx.doi.org/10.1002/jcp.28428DOI Listing

Theaflavin 3,3'-digallate reverses the downregulation of connexin 43 and autophagy induced by high glucose via AMPK activation in cardiomyocytes.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Theaflavin 3,3'-digallate (TF3), is reported to protect cardiomyocytes from lipotoxicity and reperfusion injury. However, the role of TF3 in the protection of high-glucose injury is still poorly understood. This study investigated the protective effects of TF3 on gap junctions and autophagy in neonatal cardiomyocytes (NRCMs). Read More

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http://dx.doi.org/10.1002/jcp.28432DOI Listing

Herbal medicine as an auspicious therapeutic approach for the eradication of Helicobacter pylori infection: A concise review.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Social Determinants of Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Helicobacter pylori (H. pylori) causes gastric mucosa inflammation and gastric cancer mostly via several virulence factors. Induction of proinflammatory pathways plays a crucial role in chronic inflammation, gastric carcinoma, and H. Read More

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http://dx.doi.org/10.1002/jcp.28363DOI Listing
March 2019
2 Reads

Extracellular vesicles in bone and tooth: A state-of-art paradigm in skeletal regeneration.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

State Key Laboratory of Oral Diseases, Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.

Bone and tooth, fundamental parts of the craniofacial skeleton, are anatomically and developmentally interconnected structures. Notably, pathological processes in these tissues underwent together and progressed in multilevels. Extracellular vesicles (EVs) are cell-released small organelles and transfer proteins and genetic information into cells and tissues. Read More

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http://dx.doi.org/10.1002/jcp.28303DOI Listing
March 2019
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Anticancer activities of chalcone flavokawain B from Alpinia pricei Hayata in human lung adenocarcinoma (A549) cells via induction of reactive oxygen species-mediated apoptotic and autophagic cell death.

J Cell Physiol 2019 Mar 7. Epub 2019 Mar 7.

Department of Nutrition, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung, Taiwan.

Chalcones found in fruits and vegetables have promising cancer chemopreventive properties. This study attempts to identify the anticancer efficacies of chalcone flavokawain B (FKB) in the rhizomes of Alpinia pricei Hayata by examining key molecular events in non-small-cell lung cancer (A549) cells. Our results indicated that in human A549 cells, FKB (0-15 μg/ml) decreases cell viability and colony formation, dysregulates the Bax:B-cell lymphoma 2 ratio and increases apoptotic DNA fragmentation. Read More

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http://dx.doi.org/10.1002/jcp.28375DOI Listing
March 2019
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Antiplatelet, antioxidative, and anti-inflammatory effects of hydroquinone.

J Cell Physiol 2019 Mar 6. Epub 2019 Mar 6.

School of Dentistry & Department of Dentistry, National Taiwan University Medical College and National Taiwan University Hospital, Taipei, Taiwan.

Platelets play crucial roles in thrombosis and hemostasis through platelet activation and aggregation that are crucial in cardiovascular diseases. Hydroquinone (HQ) and its derivatives are present in many dermatological creams, paints, motor fuels, air, microorganisms, and plant products like wheat bread, fruit, coffee, and red wine. The effect of HQ on humans is not clear. Read More

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http://doi.wiley.com/10.1002/jcp.28444
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http://dx.doi.org/10.1002/jcp.28444DOI Listing
March 2019
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Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts.

J Cell Physiol 2019 Mar 6. Epub 2019 Mar 6.

MOH Key Laboratory of Thrombosis and Hemostasis, Collaborative Innovation Center of Hematology-Thrombosis and Hemostasis Group, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Medical College, Soochow University, Suzhou, China.

The matrix remodeling associated 7 (MXRA7) gene had been ill-studied and its biology remained to be discovered. Inspired by our previous findings and public datasets concerning MXRA7, we hypothesized that the MXRA7 gene might be involved in bone marrow mesenchymal stem cells (BMSCs) functions related to bone formation, which was checked by utilizing in vivo or in vitro methodologies. Micro-computed tomography of MXRA7-deficient mice demonstrated retarded osteogenesis, which was reflected by shorter femurs, lower bone mass in both trabecular and cortical bones compared with wild-type (WT) mice. Read More

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http://dx.doi.org/10.1002/jcp.28438DOI Listing
March 2019
4 Reads

FTY720 alleviates coxsackievirus B3-induced myocarditis and inhibits viral replication through regulating sphingosine 1-phosphate receptors and AKT/caspase-3 pathways.

J Cell Physiol 2019 Mar 6. Epub 2019 Mar 6.

Department of Cardiology, Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Ministry of Public Health, Shanghai, China.

Fingolimod (FTY720) after phosphorylation, as the ligand of sphingosine 1-phosphate receptors (S1PRs), plays an important role in cell proliferation and differentiation. In this article, FTY720 in the treatment of coxsackievirus B3 (CVB3)-induced viral myocarditis was closely related to apoptosis and AKT/caspase-3 apoptotic pathways. We found that CVB3 inhibited myocardial apoptosis at the early stage with upregulating p-AKT level and downregulating activated caspase-3 level for replication of virus progeny, whereas it promoted apoptosis at a late stage with downregulating p-AKT and upregulating activated caspase-3 for releasing the newly synthesized virus to spread. Read More

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http://dx.doi.org/10.1002/jcp.28434DOI Listing

Renal effects of general anesthesia from old to recent studies.

J Cell Physiol 2019 Mar 6. Epub 2019 Mar 6.

Department of Internal Medicine, School of Medicine Sina Hospital Tehran University of Medical Sciences, Tehran, Iran.

Various types of anesthesia are being utilized to maintain physiologically secured surgical conditions. Nearly all categories of general anesthesia are characterized by various perioperative and postoperative complications. These shortcomings are important aspects that need to be considered by the anesthesiologist and surgeon before administration of these compounds. Read More

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http://dx.doi.org/10.1002/jcp.28407DOI Listing

Long noncoding RNAs biomarker-based cancer assessment.

J Cell Physiol 2019 Mar 5. Epub 2019 Mar 5.

Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Cancer diagnosis have mainly relied on the incorporation of molecular biomarkers as part of routine diagnostic tool. The molecular alteration ranges from those involving DNA, RNA, noncoding RNAs (microRNAs and long noncoding RNAs [lncRNAs]) and proteins. lncRNAs are recently discovered noncoding endogenous RNAs that critically regulates the development, invasion, and metastasis of cancer cells. Read More

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http://dx.doi.org/10.1002/jcp.28417DOI Listing
March 2019
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Identification of esophageal cancer pathway deviation and construction of a diagnosis model using three kernel genes.

J Cell Physiol 2019 Mar 5. Epub 2019 Mar 5.

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

The purpose of this study is to better understand the role of interleukin 35 (IL35) in esophageal carcinoma by comparing the mRNA level in Barrett's esophageal mucosa and in matched normal squamous mucosa and to understand how the diagnosis model works with two other genes: hepatocyte nuclear factor 1B (HNF1B) and cAMP responsive element binding protein 3-like 1 (CREB3L1). By comparing carcinoma tissue and normal tissue samples, we extracted all the differentially expressed mRNAs. The bioinformatics analysis resulted in the discovery of three prominent genes. Read More

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http://dx.doi.org/10.1002/jcp.28442DOI Listing

Combination therapy with dacarbazine and statins improved the survival rate in mice with metastatic melanoma.

J Cell Physiol 2019 Mar 4. Epub 2019 Mar 4.

Division of Pharmacotherapy, Kindai University Faculty of Pharmacy, Kowakae, Higoshi-Osaka, Osaka, Japan.

Malignant melanoma is a highly aggressive skin cancer, and the overall median survival in patients with metastatic melanoma is only 6-9 months. Although molecular targeted therapies have recently been developed and have improved the overall survival, melanoma patients may show no response and acquisition of resistance to these drugs. Thus, other molecular approaches are essential for the treatment of metastatic melanoma. Read More

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http://dx.doi.org/10.1002/jcp.28430DOI Listing

miR-144-3p facilitates nasopharyngeal carcinoma via crosstalk with PTEN.

J Cell Physiol 2019 Mar 4. Epub 2019 Mar 4.

Department of Otorhinolaryngology Head and Neck Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China.

Aims: This study aims to investigate the role of miR-144-3p and phosphatase and tensin homolog (PTEN) in nasopharyngeal carcinoma (NPC), along with their crosstalk with the phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) pathway.

Methods: Quantitative reverse transcription polymerase chain reaction and western blot were used to measure the gene expression at the transcriptional and translational levels. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and colony formation assay were used to examine cell proliferation via standard protocol. Read More

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http://dx.doi.org/10.1002/jcp.28424DOI Listing

Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running.

J Cell Physiol 2019 Mar 4. Epub 2019 Mar 4.

Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.

To identify the effects of running on articular cartilage and subchondral bone remodeling, C57BL/6 mice were randomly divided into three groups: control, moderate-, and strenuous running. Magnetic resonance imaging showed bone marrow lesions in the knee subchondral bone in the strenuous-running group in contrast with the other two groups. The microcomputed tomography analysis showed promoted bone formation in the subchondral bone in mice subjected to strenuous running. Read More

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http://dx.doi.org/10.1002/jcp.28427DOI Listing

Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA-5581-3p/human cardiolipin synthase 1.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Department of Gastroenterology, The First Affiliated to Chinese PLA General Hospital, Beijing, China.

Hepatocellular carcinoma (HCC) is one of the most common malignancies with extremely high rates of occurrence and death. Long noncoding RNAs (lncRNAs) have been increasingly revealed to participate in tumorigenesis and development of multiple human cancers, including HCC. LINC00961 is a novel lncRNA which has been uncovered as a tumor suppressor in lung cancer and glioma. Read More

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http://dx.doi.org/10.1002/jcp.28383DOI Listing
March 2019
2 Reads

High cholesterol inhibits tendon-related gene expressions in tendon-derived stem cells through reactive oxygen species-activated nuclear factor-κB signaling.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Clinical studies have indicated that increased serum cholesterol levels raised the risk of tendinopathy in hypercholesterolemia, but the effect of cholesterol on tendon-derived stem cells (TDSCs) and its underlying mechanism have not been studied. The purpose of this study is to investigate the association between cholesterol and tendinopathy in vitro and in vivo, and its underlying molecular mechanism as well. In TDSCs, the effect of cholesterol was assessed by quantitative polymerase chain reaction, western blot analysis, and immunofluorescence staining. Read More

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http://dx.doi.org/10.1002/jcp.28433DOI Listing
March 2019
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Metabolic effects of antidiabetic drugs on adipocytes and adipokine expression.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Several classes of antidiabetic agents have been developed that achieve their hypoglycemic outcomes via various molecular mechanisms. Adipose tissue is a major metabolic and energy-storing tissue and plays an important role in many metabolic pathways, including insulin signaling and insulin sensitivity. Adipose tissue monitors and regulates whole body homeostasis via production and release of potent proteins, such as adipokine and adiponectin, into the circulation. Read More

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http://dx.doi.org/10.1002/jcp.28420DOI Listing
March 2019
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HMGA2 and Bach-1 cooperate to promote breast cancer cell malignancy.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

During breast cancer progression, tumor cells acquire multiple malignant features. The transcription factors and cell cycle regulators high mobility group A2 (HMGA2) and BTB and CNC homology 1 (Bach-1) are overexpressed in several cancers, but the mechanistic understanding of how HMGA2 and Bach-1 promote cancer development has been limited. We found that HMGA2 and Bach-1 are overexpressed in breast cancer tissues and their expression correlates positively in tumors but not in normal tissues. Read More

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http://dx.doi.org/10.1002/jcp.28397DOI Listing

Long-chain noncoding RNA GAS5 mediates oxidative stress in cardiac microvascular endothelial cells injury.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.

This study is performed to figure out the role of long-chain noncoding RNA growth-arrest specific transcript 5 (GAS5) in homocysteine (HCY)-induced cardiac microvascular endothelial cells (CMECs) injury. CMECs were cultured and the model of CMECs injury was established by coincubation with HCY. To construct stable overexpression of GAS5 cells, the expression of GAS5, microRNA-33a-5p (miR-33a-5p) and ATP-binding cassette transporter A1 (ABCA1), and biological characteristics of cells were determined. Read More

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http://dx.doi.org/10.1002/jcp.28388DOI Listing

Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen, China.

Vitamin D is a fat-soluble vitamin and plays an important role in calcium absorption and bone development, whose lack can cause a variety of diseases, including cancer. Human epidemiological studies suggested that vitamin D3 deficiency might increase glioma incidence, but molecular mechanism is less understood. In this study, we show that 1,25-dihydroxyvitamin D3 (the active form of vitamin D3) induces senescence of glioma cells and increases the expression of senescence markers, INK4A and cyclin-dependent kinase inhibitor 1A (CDKN1A). Read More

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http://dx.doi.org/10.1002/jcp.28431DOI Listing

Altered gene expression of hydrogen sulfide-producing enzymes in the liver and muscles tissues of hyperthyroid rats.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Thyroid hormones have a role in the regulation of hydrogen sulfide (H S) biosynthesis. In this study, we determined the effects of hyperthyroidism on H S levels in various tissues and messenger RNA (mRNA) expression of cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST) in the liver and muscles of the rat. Sixteen male Wistar rats were divided into the hyperthyroid and the control groups. Read More

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http://dx.doi.org/10.1002/jcp.28426DOI Listing
March 2019
3.839 Impact Factor

Angiotensin-converting enzyme inhibitors attenuated advanced glycation end products-induced renal tubular hypertrophy via enhancing nitric oxide signaling.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan, Taiwan, ROC.

Advanced glycation end products (AGE) and angiotensin II were closely correlated with the progression of diabetic nephopathy (DN). Nitric oxide (NO) is a protective mediator of renal tubular hypertrophy in DN. Here, we examined the molecular mechanisms of angiotensin-converting enzyme inhibitor (ACEI) and NO signaling responsible for diminishing AGE-induced renal tubular hypertrophy. Read More

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http://dx.doi.org/10.1002/jcp.28369DOI Listing

Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.

In the present study, we investigated the role of PKR-like endoplasmic reticular kinase (PERK), an endoplasmic reticulum (ER) stress kinase, in endothelin 1 (ET-1)- and thrombin-induced pulmonary fibrosis (PF), and the preventive effects of curcumin (CUR). Using the human embryonic WI-38 lung fibroblast cell line, ET-1 and thrombin induced the expression of ER stress-related proteins (CCAAT-enhancer-binding protein homologous protein, PERK, and binding immunoglobulin protein), a profibrogenic factor (cellular communication network factor 2 [CCN2]), and differentiation markers including α-smooth muscle actin (α-SMA), collagen I (Col I), and Col IV. Knockdown of PERK expression via small interfering RNA (siRNA) significantly reduced the increases in CCN2, α-SMA, Col I, and Col IV proteins in WI-38 cells according to western blot analysis and immunohistochemistry (IHC). Read More

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http://dx.doi.org/10.1002/jcp.28256DOI Listing

Characterization of metabolic profiles and lipopolysaccharide effects on porcine vascular wall mesenchymal stem cells.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy.

The link between metabolic remodeling and stem cell fate is still unclear. To explore this topic, the metabolic profile of porcine vascular wall mesenchymal stem cells (pVW-MSCs) was investigated. At the first and second cell passages, pVW-MSCs exploit both glycolysis and cellular respiration to synthesize adenosine triphosphate (ATP), but in the subsequent (third to eighth) passages they do not show any mitochondrial ATP turnover. Read More

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http://dx.doi.org/10.1002/jcp.28429DOI Listing

Junctophilins emerge as novel therapeutic targets.

J Cell Physiol 2019 Mar 1. Epub 2019 Mar 1.

Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China.

Junctophilins (JPs) emerge to play key role in human pathophysiology. This family includes four subtypes (JP1-4), which are differentially detected in excitable cells. Previous work demonstrated the knockout of JPs that seriously damage physiological functions in skeletal muscle, cardiac, and neurons. Read More

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http://dx.doi.org/10.1002/jcp.28405DOI Listing
March 2019
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Inhibition of miR-148b ameliorates myocardial ischemia/reperfusion injury via regulation of Wnt/β-catenin signaling pathway.

J Cell Physiol 2019 Feb 28. Epub 2019 Feb 28.

Department of Emergency, Shandong Provincial Western Hospital, Jinan, Shandong, China.

Our work aims to elucidate the effect how microRNA-148b (miR-148b) participated in myocardial ischemia/reperfusion (I/R) injury via regulation of Wnt/β-catenin signaling pathway. The in vivo myocardial I/R models of SD rats and in vitro hypoxia/reoxygenation (H/R) models of H9C2 cells were established. The heart function and infarction area of rats and lactic dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), and superoxide dismutase (SOD) levels were evaluated. Read More

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http://dx.doi.org/10.1002/jcp.28401DOI Listing
February 2019

PVT1 (rs13281615) and miR-146a (rs2910164) polymorphisms affect the prognosis of colon cancer by regulating COX2 expression and cell apoptosis.

J Cell Physiol 2019 Feb 28. Epub 2019 Feb 28.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

In this study, we aimed to investigate the potential correlation between rs13281615/rs2910164 polymorphisms and the prognosis of colon cancer (CC). Taqman was utilized to genotype the rs13281615/rs2910164 polymorphisms in recruited subjects. Kaplan-Meier survival curves were calculated to study the prognostic values of different genotypes of rs13281615/rs2910164 polymorphisms. Read More

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http://dx.doi.org/10.1002/jcp.28377DOI Listing
February 2019

TRIM72 contributes to cardiac fibrosis via regulating STAT3/Notch-1 signaling.

J Cell Physiol 2019 Feb 28. Epub 2019 Feb 28.

Department of Cardiovascular Surgery, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen, China.

Cardiac fibrosis is a pathophysiological process characterized by excessive deposition of extracellular matrix. We developed a cardiac hypertrophy model using transverse aortic constriction (TAC) to uncover mechanisms relevant to excessive deposition of extracellular matrix in mouse myocardial cells. TAC caused upregulation of Tripartite motif protein 72 (TRIM72), a tripartite motif-containing protein that is critical for proliferation and migration. Read More

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http://dx.doi.org/10.1002/jcp.28400DOI Listing
February 2019
1 Read