14,857 results match your criteria Journal of Cellular Physiology [Journal]


Apical cell protrusions cause vertical deformation of the soft cancer nucleus.

J Cell Physiol 2019 Apr 21. Epub 2019 Apr 21.

Department of Chemical Engineering, University of Florida, Gainesville, Florida.

Breast cancer nuclei have highly irregular shapes, which are diagnostic and prognostic markers of breast cancer progression. The mechanisms by which irregular cancer nuclear shapes develop are not well understood. Here we report the existence of vertical, apical cell protrusions in cultured MDA-MB-231 breast cancer cells. Read More

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http://dx.doi.org/10.1002/jcp.28672DOI Listing

The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Endometriosis is a frequent and chronic illness in young women which could be defined by the existence of endometrial stroma and glands outside of the normal site of the lining of the uterus. It has painful symptoms. The advanced stage of endometriosis may lead to gynecological malignancies, such as ovarian cancer, and other complications, including infertility. Read More

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http://dx.doi.org/10.1002/jcp.28666DOI Listing

Low-dose aspirin reduces hypoxia-induced sFlt1 release via the JNK/AP-1 pathway in human trophoblast and endothelial cells.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Pre-eclampsia (PE) is a serious hypertensive disorder of pregnancy that remains a leading cause of perinatal and maternal morbidity and mortality worldwide. Placental ischemia/hypoxia and the secretion of soluble fms-like tyrosine kinase 1 (sFlt1) into maternal circulation are involved in the pathogenesis of PE. Although low-dose aspirin (LDA) has beneficial effects on the prevention of PE, the exact mechanisms of action of LDA, particularly on placental dysfunction, and sFlt1 release, have not been well investigated. Read More

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http://dx.doi.org/10.1002/jcp.28533DOI Listing

New potentials for 3-hydroxy-3-methyl-glutaryl-coenzymeA reductase inhibitors: Possible applications in retarding diabetic complications.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.

The prevalence of diabetes mellitus is increasing all over the world and it is apparent that treatment of diabetic complications has the same importance as primary diabetes treatment and glycemic control. Diabetic complications occur as a result of prolonged hyperglycemia and its consequences, such as advanced glycation end products and reactive oxygen species. Impairment of lipid profile is also contributed to worsening diabetic complications. Read More

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http://dx.doi.org/10.1002/jcp.28682DOI Listing

9za plays cytotoxic and proapoptotic roles and induces cytoprotective autophagy through the PDK1/Akt/mTOR axis in non-small-cell lung cancer.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Non-small-cell lung cancer (NSCLC) is an aggressive subtype of pulmonary carcinomas with high mortality. However, chemotherapy drug resistance and high recurrence rates hinder the curative effect of platinum-based first-line chemotherapy, which makes it urgent to develop new antitumor drugs for NSCLC. 9za, a new candidate drug synthesized by our research group, has been verified with potent antilung cancer activity in preliminary experiments. Read More

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http://dx.doi.org/10.1002/jcp.28679DOI Listing
April 2019
2 Reads

N-myc downstream-regulated gene 2 controls astrocyte morphology via Rho-GTPase signaling.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Anesthesia and Operation Center, The First Medical Center to Chinese PLA General Hospital, Beijing, China.

Astrocyte undergoes morphology changes that are closely associated with the signaling communications at synapses. N-myc downstream-regulated gene 2 (NDRG2) is specifically expressed in astrocytes and is associated with several important astrocyte functions, but its potential role(s) relating to astrocyte morphological changes remain unknown. Here, primary astrocytes were prepared from neonatal Ndrg2 and Ndrg2 pups, and the drug Y27632 was used to induce stellation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28689
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http://dx.doi.org/10.1002/jcp.28689DOI Listing
April 2019
1 Read

Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Cellular and Molecular Neurobiology Unit, Indian Institute of Technology, Jodhpur, Rajasthan, India.

Major neurodegenerative disorders are characterized by the formation of misfolded proteins aggregates inside or outside the neuronal cells. Previous studies suggest that aberrant proteins aggregates play a critical role in protein homeostasis imbalance and failure of protein quality control (PQC) mechanism, leading to disease conditions. However, we still do not understand the precise mechanisms of PQC failure and cellular dysfunctions associated with neurodegenerative diseases caused by the accumulation of protein aggregates. Read More

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http://dx.doi.org/10.1002/jcp.28695DOI Listing

Combinational therapy of lithium and human neural stem cells in rat spinal cord contusion model.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Brain and Cognitive Sciences, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

A large number of treatment approaches have been used for spinal cord injury improvement, a medically incurable disorder, and subsequently stem cell transplantation appears to be a promising strategy. The main objective of this study is to ascertain whether combinational therapy of human neural stem cells (hNSCs) together with lithium chloride improves cell survival, proliferation, and differentiation in a rat spinal contusion model, or not. Contusive spinal cord injury was implemented on Wistar male rats. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28680
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http://dx.doi.org/10.1002/jcp.28680DOI Listing
April 2019
1 Read

Long noncoding RNA C2dat1 protects H9c2 cells against hypoxia injury by downregulating miR-22.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Myocardial ischemia is accompanied with hypoxia injury in myocardial cells. Long noncoding RNAs (lncRNA) CAMK2D-associated transcript 1 (C2dat1) C2dat1) has been linked with several ischemic diseases. However, the investigation regarding its role in myocardial ischemia is relatively rare. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28667
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http://dx.doi.org/10.1002/jcp.28667DOI Listing
April 2019
2 Reads

Intelligent TAT-coupled anti-HER2 immunoliposomes knock downed MDR1 to produce chemosensitize phenotype of multidrug resistant carcinoma.

J Cell Physiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Gene therapy using biocompatible cationic liposomes is amongst promising approaches that decreases death from cancers. Here an invasive multidrug resistant cell model has been developed by lentiviral transfection. In parallel phospholipids have been covalently conjugated to TAT, MMP2, and Herceptin. Read More

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http://dx.doi.org/10.1002/jcp.28683DOI Listing

Nimotuzuma restrains proliferation and induces apoptosis in human osteosarcoma cells by regulation of EGFR/PI3K/AKT signal pathway.

J Cell Physiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Osteosarcoma (OS) is a conversant malignant bone tumor, commonly occurs in children and adolescents. Nimotuzuma is an epidermal growth factor receptor (EGRF) monoclonal antibody agent, which has been exploited in varied solid tumors. Nevertheless, the functions of Nimotuzuma in OS remain blurry. Read More

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http://dx.doi.org/10.1002/jcp.28693DOI Listing

Protein kinase D1 inhibition interferes with mitosis progression.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Inmunología, Genética y Metabolismo, Facultad de Farmacia y Bioquímica, Hospital de Clínicas "José de San Martín," Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires (CABA), Buenos Aires, Argentina.

Protein kinase D1 (PKD1) plays a vital role in signal transduction, cell proliferation, membrane trafficking, and cancer; however, the majority of the studies up to date had centered primarily on PKD1 functions in interphase, very little is known about its role during cell division. We previously demonstrated that during mitosis PKD1 is activated and associated with centrosomes, spindles, and midbodies. However, these observations did not address whether PKD1 was associated with mitosis regulation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28651
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http://dx.doi.org/10.1002/jcp.28651DOI Listing
April 2019
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Potential of stem cell-derived exosomes to regenerate β islets through Pdx-1 dependent mechanism in a rat model of type 1 diabetes.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Type 1 diabetes, has been recognized as an autoimmune disease. Like other immunological conditions, regulation of immune response is a key strategy to control the autoimmunity in diabetic patients. Mesenchymal stem cells have been shown to have a distinct potential in modulating the immune reactions. Read More

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http://dx.doi.org/10.1002/jcp.28631DOI Listing

A feed-forward regulatory network lncPCAT1/miR-106a-5p/E2F5 regulates the osteogenic differentiation of periodontal ligament stem cells.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, China.

Periodontal ligament stem cells (PDLSCs) are characterized by multiple differentiation potential and potent self-renewal ability, yet much remains to be elucidated that what determines these properties. Long noncoding RNAs (lncRNAs) have been suggested to involve in multiple biological process under physiological and pathological conditions, including osteogenic differentiation. In the present study, we performed comprehensive lncRNA profiling by lncRNA microarray analysis and identified prostate cancer-associated ncRNA transcript-1 (lncPCAT1) was gradually increased in PDLSCs during consecutive osteogenic induction, and it could further positively regulate the osteogenic differentiation both in vitro and in vivo, whereas lncPCAT1 inhibition led to suppressed osteogenic differentiation. Read More

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http://dx.doi.org/10.1002/jcp.28550DOI Listing

A novel microRNA signature predicts vascular invasion in hepatocellular carcinoma.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Vascular invasion (VI) in hepatocellular carcinoma (HCC) is an important clinical parameter to predict survival. In this study, we collected microRNA (miRNA) expression data from HCC patients using The Cancer Genome Atlas database and identified a novel miRNA signature associated with VI. First, we categorized HCC patients into groups with or without VI (VI+ and VI-). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28690
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http://dx.doi.org/10.1002/jcp.28690DOI Listing
April 2019
1 Read

Prognostic utility and clinical significance of lysyl oxidase-like 2 protein expression in digestive system cancers.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Hepatobiliary Surgery, Meizhou People's Hospital, Meizhou, Guangdong, P. R. China.

Lysyl oxidase-like 2 (LOXL2) participates in the occurrence and development of digestive system cancers (DSCs). The aim of this study was to determine whether LOXL2 protein could serve as a prognostic biomarker in patients with DSCs. Relevant studies published before October 1, 2018 were identified from a comprehensive literature review in PubMed, Web of Science, and Embase. Read More

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http://dx.doi.org/10.1002/jcp.28677DOI Listing

Asprosin attenuates insulin signaling pathway through PKCδ-activated ER stress and inflammation in skeletal muscle.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

It has been reported that asprosin is a novel adipokine which is augmented in mice and humans with type 2 diabetes (T2DM). Asprosin stimulates hepatic gluconeogenesis under fasting conditions. However, the roles of asprosin in inflammation, endoplasmic reticulum (ER) stress, and insulin resistance in skeletal muscle has not been studied. Read More

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http://dx.doi.org/10.1002/jcp.28694DOI Listing

Generation of a nitric oxide signaling pathway in mesenchymal stem cells promotes endothelial lineage commitment.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

School of Health, Medicine and Applied Sciences, Central Queensland University, Rockhampton, Queensland, Australia.

Enhancing differentiation of mesenchymal stem cells (MSCs) to endothelial cells may improve their ability to vascularize tissue and promote wound healing. This study describes a novel role for nitric oxide (NO) in reprogramming MSCs towards an endothelial lineage and highlights the role of Wnt signaling and epigenetic modification by NO. Rat MSCs were transduced with lentiviral vectors expressing endothelial nitric oxide synthase (pLV-eNOS) and a mutated caveolin gene (pLV-CAV-1 ) to enhance NO generation resulting in increased in vitro capillary tubule formation and endothelial marker gene expression. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28640
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http://dx.doi.org/10.1002/jcp.28640DOI Listing
April 2019
2 Reads

High expression of miR-338 is associated with poor prognosis in acute myeloid leukemia undergoing chemotherapy.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Blood Diseases Institute, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Acute myeloid leukemia (AML) is a heterogeneous disease with unfavorable outcomes. MicroRNAs (miRNAs) are important regulators and prognostic factors involved in AML. To determine the clinical role of miR-338 in AML, a total of 164 adults with de novo AML were collected. Read More

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http://dx.doi.org/10.1002/jcp.28676DOI Listing
April 2019
1 Read

Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Public Health, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan.

Chemoresistance is one of the major obstacles in chemotherapy-based hepatocellular carcinoma (HCC) intervention. Aluminum (Al) is an environmental pollutant that plays a vital role in carcinogenesis, tumorigenesis, and metastasis. However, the effect of Al on chemoresistance remains unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28625
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http://dx.doi.org/10.1002/jcp.28625DOI Listing
April 2019
2 Reads

Bacterial l-asparaginases for cancer therapy: Current knowledge and future perspectives.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

l-Asparaginases hydrolyzing plasma l-asparagine and l-glutamine has attracted tremendous attention in recent years owing to remarkable anticancer properties. This enzyme is efficiently used for acute lymphoblastic leukemia (ALL) and lymphosarcoma and emerged against ALL in children, neoplasia, and some other malignancies. Cancer cells reduce the expression of l-asparaginase leading to their elimination. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28563
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http://dx.doi.org/10.1002/jcp.28563DOI Listing
April 2019
2 Reads

Overexpression of microRNA-186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Strabismus & Pediatric Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, People's Republic of China.

Retinoblastoma (RB) represents an aggressive malignancy in the eye during the period of infancy and childhood. We delineated the ability of microRNA-186 (miR-186) to influence viability, invasion, migration, angiogenesis, and apoptosis of RB via the Hedgehog signaling pathway by targeting AAA domain-containing protein 2 (ATAD2). The microarray-based analysis was adopted to identify differentially expressed genes (DEGs) related to RB. Read More

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http://dx.doi.org/10.1002/jcp.28545DOI Listing
April 2019
3.839 Impact Factor

NK cells: An attractive candidate for cancer therapy.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Stem Cell Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.

Natural killer (NK) cells have significant capability in tumor immune-surveillance. The ability of lyse transformed cells immediately in an antigen-independent manner make them an attractive candidate for cancer cell therapy. Despite employment of NK cells in cancer immunotherapy, clinical trials are faced with serious limitations such as trouble with the penetration of NK cells in tumor sites, limited in vivo persistence, and tumor microenvironment interference. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28657
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http://dx.doi.org/10.1002/jcp.28657DOI Listing
April 2019
1 Read

Overexpression of microRNA-190 inhibits migration, invasion, epithelial-mesenchymal transition, and angiogenesis through suppression of protein kinase B-extracellular signal-regulated kinase signaling pathway via binding to stanniocalicin 2 in breast cancer.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Oncology, Liaocheng People's Hospital, Liaocheng, P.R. China.

Breast cancer (BC) is known as the most deadly cancer among females, worldwide. Despite the research advances in this regard, effective diagnosis and treatment still have a long way to go. In this study, our stance was to investigate the regulatory mechanism of miR-190 on epithelial-mesenchymal transition (EMT) and angiogenesis via mediation of protein kinase B (AKT)-extracellular signal-regulated kinase (ERK) signaling pathway by targeting stanniocalicin 2 (STC2) in BC. Read More

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http://dx.doi.org/10.1002/jcp.28409DOI Listing

Administration of dexamethasone disrupts endometrial receptivity by alteration of expression of miRNA 223, 200a, LIF, Muc1, SGK1, and ENaC via the ERK1/2-mTOR pathway.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Genetic, Facualty of Medcine, Tabriz University of Medical Sciences, Tabriz, Iran.

Successful implantation of embryos requires endometrial receptivity. Glucocorticoids are one of the factors influencing the implantation window. In this study, 40 female BALB/c mice were used to study the impacts of dexamethasone administration on endometrial receptivity markers during implantation window. Read More

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http://dx.doi.org/10.1002/jcp.28562DOI Listing
April 2019
1 Read

Long noncoding RNA PTPRG-AS1 acts as a microRNA-194-3p sponge to regulate radiosensitivity and metastasis of nasopharyngeal carcinoma cells via PRC1.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Protein regulator of cytokinesis 1 (PRC1) has been reported in correlation with various malignancies. Functionality of PRC1 in nasopharyngeal carcinoma (NPC) was investigated, in perspective of long noncoding RNA (lncRNA) regulatory circuitry. Aberrant expressed messenger RNA and lncRNA were screened out from the Gene Expression Omnibus microarray database. Read More

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http://dx.doi.org/10.1002/jcp.28547DOI Listing

Downregulation of lysyl oxidase-like 4 LOXL4 by miR-135a-5p promotes lung cancer progression in vitro and in vivo.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuchang District, Wuhan, China.

Aberrant microRNAs are widely identified in multiple cancers, including lung cancer. miR-135a-5p can function as a significant tumor regulator in diverse cancers via impacting multiple genes in oncogenic pathways. Nevertheless, the biological role of miR-135a-5p in lung cancer is poorly known. Read More

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http://dx.doi.org/10.1002/jcp.28508DOI Listing

The effects of training on hormonal concentrations in young soccer players.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Dipartimento di Scienze e Tecnologie Biologiche e Ambientali (Di.S.Te.B.A.), Università del Salento, Lecce, Italy.

To test the hypothesis that football training would be accompanied by physiological adaptations and hormonal changes, we analyzed the effects of a whole football season on physical fitness and hormonal concentrations in youth football players. Male football players (n = 29, age 16.51 ± 0. Read More

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http://dx.doi.org/10.1002/jcp.28673DOI Listing

Biomechanical properties of red blood cells infected by Plasmodium berghei ANKA.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

Malaria is a pathogenic disease in mammal species and typically causes destruction of red blood cells (RBCs). The malaria-infected RBCs undergoes alterations in morphology and its rheological properties, and the altered rheological properties of RBCs have a significant impact on disease pathophysiology. In this study, we investigated detailed topological and biomechanical properties of RBCs infected with malaria Plasmodium berghei ANKA using atomic force microscopy. Read More

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http://dx.doi.org/10.1002/jcp.28654DOI Listing
April 2019
1 Read

Exosome-based intercellular communication in female reproductive microenvironments.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Different strategies are applied for cellular cross-talk and organization in multicellular organisms. Exosomes are a homogenous population of biological nanoparticles (30-100 nm), originated from multivesicular bodies. The exosomes (Exos) could regulate and affect both cellular physiology and pathophysiology in various organs, such as the female reproductive tract, by altering gene pathways and/or epigenetic programming. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28668
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http://dx.doi.org/10.1002/jcp.28668DOI Listing
April 2019
1 Read

PPARγ promotes diabetes-associated centrosome amplification via increasing the expression of SKA1 directly at the transcriptional level.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Biology, School of Life Sciences, Shanxi University, Taiyuan, Shanxi, PR China.

We have recently published that type 2 diabetes can induce cell centrosome amplification due to the action of high glucose, palmitic acid, and insulin, and ROCK1 and 14-3-3σ are signal mediators. In this study, we further investigated the molecular mechanisms of the centrosome amplification in colon cancer HCT116 cells. Treatment of the cells with high glucose, palmitic acid, and insulin increased the expression of peroxisome proliferator-activated receptor γ (PPARγ) as well as the spindle and kinetochore associated protein 1 (SKA1), knockdown of each of which resulted in the inhibition of the treatment-triggered centrosome amplification. Read More

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http://dx.doi.org/10.1002/jcp.28674DOI Listing

Loss of G3BP1 suppresses proliferation, migration, and invasion of esophageal cancer cells via Wnt/β-catenin and PI3K/AKT signaling pathways.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Life Science and Bioengineering, Beijing University of Technology, Beijing, P. R. China.

Accumulating evidence suggests that Ras GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is very crucial to regulate tumorigenesis and metastasis. Recently, many research works have suggested that G3BP1 is overexpressed in many human cancers including esophageal cancer. Nevertheless, the functional roles of G3BP1 in esophageal cancer are still unknown. Read More

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http://dx.doi.org/10.1002/jcp.28648DOI Listing

UHRF1 is regulated by miR-124-3p and promotes cell proliferation in intrahepatic cholangiocarcinoma.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Ministry of Education, Shanghai, China.

Ubiquitin-like with PHD and ring finger domains 1 (UHRF1) is abnormally overexpressed in multiple cancers and closely correlated with tumor-promoting effects, such as high proliferation. However, how UHRF1 functions in intrahepatic cholangiocarcinoma (ICC) has not yet been determined. Herein, we found that UHRF1 is overexpressed in ICC tissues. Read More

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http://dx.doi.org/10.1002/jcp.28586DOI Listing
April 2019
1 Read

Endoplasmic reticulum stress, a novel significant mechanism responsible for DEHP-induced increased distance between seminiferous tubule of mouse testis.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Institute of Biomedical Sciences, Shandong Normal University, Jinan, Shandong, China.

Di(2-ethylhexyl) phthalate (DEHP), a widely existed endocrine disruptor, has been concerned for many years owing to its toxicity in male reproductive development. In this study, we investigated the reproductive effects and the mechanism of mouse testis after in uterus exposure to the plasticizer DEHP. We found that the UPR signaling pathway could be fully activated after DEHP treatment. Read More

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http://dx.doi.org/10.1002/jcp.28580DOI Listing
April 2019
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Identification of the potential key genes for adipogenesis from human mesenchymal stem cells by RNA-Seq.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Jiangxi Provincial Key Laboratory of Systems Biomedicine, Jiujiang University, Jiujiang, China.

Adipogenesis, a physiological process initiated with the committed preadipocytes expressing adipocyte-specific genes and terminated in mature, differentiated and functional adipocytes, mainly involved with energy homeostasis. Abnormal distribution-changes and dysfunctions in adipogenesis may lead to complex physiopathological disorders. However, it remains unclear for the key players working for the whole complex differentiating process of adipogenesis. Read More

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http://dx.doi.org/10.1002/jcp.28621DOI Listing
April 2019
2 Reads

Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMP-2 and MMP-9 via H19/miR-29b-3p and AKT/mTOR/autophagy signaling pathways.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

In this study, we aimed to investigate the molecular pathway(s) underlying the effect of metformin (MET) on the expression of matrix metalloproteinase (MMP)-2 and MMP-9. Real-time polymerase chain reaction, Western blot analysis, and gelatin zymography were used to assay the effects of MET on MMP and AMPK signaling pathways. In addition, HTOG cells were treated with miR-29b-3p/a scramble control, H19/a negative control, or MET/PBS to explore possible signaling pathway(s) underlying the inhibitory effect of MET on MMP-2/MMP-9. Read More

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http://dx.doi.org/10.1002/jcp.28594DOI Listing
April 2019
1 Read

Hypoxic regulation of angiotensin-converting enzyme 2 and Mas receptor in human CD34 cells.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Pharmaceutical Sciences, College of Health Professions, North Dakota State University, Fargo, North Dakota.

CD34 hematopoietic stem/progenitor cells (HSPCs) are vasculogenic and hypoxia is a strong stimulus for the vasoreparative functions of these cells. Angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7)/Mas receptor (MasR) pathway stimulates vasoprotective functions of CD34 cells. This study tested if ACE2 and MasR are involved in the hypoxic stimulation of CD34 cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28643
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http://dx.doi.org/10.1002/jcp.28643DOI Listing
April 2019
1 Read

Silica-coated magnetic nanoparticles labeled endothelial progenitor cells alleviate ischemic myocardial injury and improve long-term cardiac function with magnetic field guidance in rats with myocardial infarction.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Department of Cardiology, Hubei Key Laboratory of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Wuhan, China.

Low retention of endothelial progenitor cells (EPCs) in the infarct area has been suggested to be responsible for the poor clinical efficacy of EPC therapy for myocardial infarction (MI). This study aimed to evaluate whether magnetized EPCs guided through an external magnetic field could augment the aggregation of EPCs in an ischemia area, thereby enhancing therapeutic efficacy. EPCs from male rats were isolated and labeled with silica-coated magnetic iron oxide nanoparticles to form magnetized EPCs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28492
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http://dx.doi.org/10.1002/jcp.28492DOI Listing
April 2019
1 Read
3.839 Impact Factor

Overexpressed long noncoding RNA CPS1-IT alleviates pulmonary arterial hypertension in obstructive sleep apnea by reducing interleukin-1β expression via HIF1 transcriptional activity.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Department of Respiratory Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling of the precapillary pulmonary arteries, with excessive proliferation of vascular cells. This study was performed to examine the effects of long noncoding RNA CPS1 intronic transcript 1 (CPS1-IT) on PAH in rat models of obstructive sleep apnea (OSA) through regulating interleukin (IL)-1β expression. The OSA models were induced in rats, for determination of the CPS1-IT expression. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28571
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http://dx.doi.org/10.1002/jcp.28571DOI Listing
April 2019
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Sumoylation of PPARγ contributes to vascular endothelium insulin resistance through stabilizing the PPARγ-NcoR complex.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Key Provincial Laboratory of Basic Pharmacology, Nanchang University, Nanchang, Jiangxi, People's Republic of China.

Sumoylation of peroxisome proliferator-activated receptor γ (PPARγ) affects its stabilization, sublocalization, and transcriptional activity. However, it remains largely unknown whether PPARγ sumoylation inhibits the transactivation effect, leading to endothelium insulin resistance (IR). To test this possibility, human umbilical vascular endothelial cells (HUVECs) with a 90% confluence were randomly allocated to two batches. Read More

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http://dx.doi.org/10.1002/jcp.28567DOI Listing

Inflammatory cytokines associated with cancer growth induce mitochondria and cytoskeleton alterations in cardiomyocytes.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

Cardiac dysfunction is often observed in patients with cancer also representing a serious problem limiting chemotherapeutic intervention and even patient survival. In view of the recently established role of the immune system in the control of cancer growth, the present work has been undertaken to investigate the effects of a panel of the most important inflammatory cytokines on the integrity and function of mitochondria, as well as of the cytoskeleton, two key elements in the functioning of cardiomyocytes. Either mitochondria features or actomyosin cytoskeleton organization of in vitro-cultured cardiomyocytes treated with different inflammatory cytokines were analyzed. Read More

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http://dx.doi.org/10.1002/jcp.28647DOI Listing

Adiponectin inhibits high glucose-induced angiogenesis via inhibiting autophagy in RF/6A cells.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Department of Ophthalmology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, People's Republic of China.

Adiponectin, one of the adipose-derived hormone with metabolic activity, has been reported to conversely affect angiogenesis of endothelial cells in vitro. The previous study in animal models has demonstrated that adiponectin has a protective role in retinal vascular injury following pathological stimuli. However, clinical research regarding the relationship between plasma adiponectin level and diabetic retinopathy (DR) are inconclusive. Read More

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http://dx.doi.org/10.1002/jcp.28659DOI Listing
April 2019
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Combinatorial effects of radiofrequency hyperthermia and radiotherapy in the presence of magneto-plasmonic nanoparticles on MCF-7 breast cancer cells.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Radiation Biology Research Center, Iran University of Medical Science (IUMS), Tehran, Iran.

Here, the effects of combinatorial cancer therapy including radiotherapy (RT) and radiofrequency (RF) hyperthermia in the presence of gold-coated iron oxide nanoparticles (Au@IONPs), as a thermo-radio-sensitizer, are reported. The level of cell death and the ratio of Bax/Bcl2 genes, involved in the pathway of apoptosis, were measured to evaluate the synergistic effect of Au@IONPs-mediated RF hyperthermia and RT. MCF-7 human breast adenocarcinoma cells were treated with different concentrations of Au@IONPs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28599
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April 2019
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The lncRNA CCAT2 rs6983267 G allele is associated with decreased susceptibility to recurrent miscarriage.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Genetics might play various roles in susceptibility to recurrent miscarriage, and previous studies suggest that some gene polymorphisms might be associated with abortion and breast cancer onset. Colon cancer-associated transcript 2 (CCAT2) is a novel long noncoding RNA (lncRNA) transcript that might be correlated with susceptibility to multiple cancers, including breast cancer. However, whether lncRNA CCAT2 polymorphisms are related to susceptibility to recurrent miscarriage is unclear. Read More

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http://dx.doi.org/10.1002/jcp.28661DOI Listing

siRNA-mediated silencing of PAI-1 gene acts as a promoter over the recanalization of endothelial progenitor cells in rats with venous thrombosis.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.

With the changing lifestyle, venous thrombosis (VT) is becoming increasingly prevalent and poses a burden on the health economy. Endothelial progenitor cells (EPCs) are recruited into resolving VT. We aimed to investigate the effect of plasminogen activator inhibitor 1 (PAI-1) silencing on the recanalization of VT in rat EPCs. Read More

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http://dx.doi.org/10.1002/jcp.28590DOI Listing
April 2019
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Transplantation of miR-219 overexpressed human endometrial stem cells encapsulated in fibrin hydrogel in spinal cord injury.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Oligodendrocyte (OL) loss and demyelination occur after spinal cord injury (SCI). Stimulation of remyelination through transplantation of myelinating cells may be effective in improving function. For the repair strategy to be successful, the selection of a suitable cell and maintaining cell growth when cells are injected directly to the site of injury is important. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28527
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http://dx.doi.org/10.1002/jcp.28527DOI Listing
April 2019
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Tumor metastasis suppressor functions of Ets transcription factor through integrin β3-mediated signaling pathway.

Authors:
Mintu Pal

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Biological Sciences and Technology Division, Biotechnology Group, CSIR-North East Institute of Science and Technology, Academy of Scientific & Innovative Research (AcSIR), Jorhat, Assam-India.

Prostate-derived Ets transcription factor (PDEF) is a member of the Ets transcription factor family originally identified in prostate tissue. PDEF functions like a tumor metastasis suppressor. Although the underlying mechanism is not very clear. Read More

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http://dx.doi.org/10.1002/jcp.28627DOI Listing

The role of cell adhesion in hematopoiesis and leukemogenesis.

J Cell Physiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Biochemistry, University of Vermont, Burlington, Vermont.

The cells of the bone marrow microenvironment are emerging as important contributors and regulators of normal hematopoiesis. This microenvironment is perturbed during leukemogenesis, and evidence points toward a bidirectional communication between leukemia cells and the normal cells of the bone marrow, mediated by direct cell-cell contact as well as soluble factors. These interactions are increasingly appreciated to play a role in leukemogenesis and possibly in resistance to chemotherapy. Read More

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http://dx.doi.org/10.1002/jcp.28636DOI Listing

Osteocytic connexin 43 channels affect fracture healing.

J Cell Physiol 2019 Apr 13. Epub 2019 Apr 13.

Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China.

The cross-talk between cells is very critical for moving forward fracture healing in an orderly manner. Connexin (Cx) 43-formed gap junctions and hemichannels mediate the communication between adjacent cells and cells and extracellular environment. Loss of Cx43 in osteoblasts/osteocytes results in delayed fracture healing. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28581
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April 2019
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CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation.

J Cell Physiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Biotechnology, Asia University, Taichung, Taiwan.

Carboxyl-terminus of Hsc70 interacting protein (CHIP) is a chaperone-dependent E3-ubiquitin ligase with important function in protein quality control system. In the current research endeavor, we have investigated the putative role of CHIP in lipopolysaccharides (LPS)-induced cardiomyopathies. Basically, H9c2 cardiomyoblasts were transfected with CHIP for 24 hr, and thereafter, treated with LPS for 12 hr. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28614
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http://dx.doi.org/10.1002/jcp.28614DOI Listing
April 2019
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