11,829 results match your criteria Journal of Cellular Biochemistry [Journal]


Knockdown of Sal-like 4 expression by siRNA induces apoptosis in colorectal cancer.

J Cell Biochem 2019 Feb 16. Epub 2019 Feb 16.

Department of Biotechnology, Molecular and Medicine Research Center, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Colorectal cancer (CRC) is known as the third most common malignancies among men and women and is also the second leading cause of cancer-related deaths worldwide. It has been indicated that a variety of risk factors are involved in the pathogenesis of CRC. Spalt-like transcription factor 4 (SALL4) is known as a transcription factor that plays an important role in the proliferation of cancerous cells. Read More

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http://dx.doi.org/10.1002/jcb.28433DOI Listing
February 2019

The skewed frequency of B-cell subpopulation CD19 CD24 CD38 cells in peripheral blood mononuclear cells is correlated with the elevated serum sCD40L in patients with active systemic lupus erythematosus.

J Cell Biochem 2019 Feb 16. Epub 2019 Feb 16.

Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

CD19 CD24 CD38 cells play an essential role in maintaining immune homeostasis. CD40 signaling is involved in regulating the induction and function of CD19 CD24 CD38 cells. Changes in B-cell subpopulations and CD19 CD24 CD38 cells have been observed in systemic lupus erythematosus (SLE) patients. Read More

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http://dx.doi.org/10.1002/jcb.28427DOI Listing
February 2019

PPAR-γ: Its ligand and its regulation by microRNAs.

J Cell Biochem 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily. PPARs are categorized into three subtypes, PPARα, β/δ, and γ, encoded by different genes, expressed in diverse tissues and participate in various biological functions and can be activated by their metabolic derivatives in the body or dietary fatty acids. The PPAR-γ also takes parts in the regulation of energy balance, lipoprotein metabolism, insulin sensitivity, oxidative stress, and inflammatory signaling. Read More

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http://dx.doi.org/10.1002/jcb.28419DOI Listing
February 2019

Hepatoprotective effects of phosphatidylserine liposomes on carbon tetrachloride-induced hepatotoxicity in rats.

J Cell Biochem 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

It has been proposed carbon tetrachloride (CCl ) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has shown antioxidant activity in numerous studies. Therefore, this study was aimed to investigate the effects of PS liposomes treatment against the CCl -induced hepatotoxicity in a rat model. Read More

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http://dx.doi.org/10.1002/jcb.28464DOI Listing
February 2019

In vitro and histological investigation of antitumor effect of some triazole compounds in colon cancer cell line.

J Cell Biochem 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemistry, Faculty of Science, Firat University, Elazig, Turkey.

1,2,4-Triazoles are used as antifungal, antibacterial, antimicrobial, and antioxidant against some oxidative radical species. Recently, many 1,2,4-triazoles continue to be synthesized. In this study, the effect of the 1,2,4-triazole derivatives on human colon cancer (HT29) was investigated in vitro and in vivo in rats. Read More

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http://dx.doi.org/10.1002/jcb.28460DOI Listing
February 2019

Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis.

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

Department of Respiratory Medicine, Shenzhen Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Guangdong, Shenzhen, China.

Pulmonary fibrosis is a lethal inflammatory disease. In this study, we aimed to explore the potential-related circular RNAs (circRNAs) and genes that are associated with pulmonary fibrosis. Pulmonary fibrosis rat models were constructed and the fibrosis deposition was detected using hematoxylin and eosin and Masson staining. Read More

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http://dx.doi.org/10.1002/jcb.28380DOI Listing
February 2019

Upregulation of long noncoding RNA SNHG20 promotes cell growth and metastasis in esophageal squamous cell carcinoma via modulating ATM-JAK-PD-L1 pathway.

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

Department of Thoracic Surgery, Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu, China.

Increasing evidence have proved that long noncoding RNAs (lncRNAs) play significant roles in tumorigenesis and development of various cancers. However, the effect of small nucleolar RNA host gene 20 (SNHG20) on the progression of esophageal squamous cell carcinoma (ESCC) remains to be discovered. Herein, we aim to find out the function and the possible mechanism of SNHG20 in ESCC progression. Read More

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http://dx.doi.org/10.1002/jcb.28444DOI Listing
February 2019

Contribution of autophagy-related gene 5 variants to acquired aplastic anemia in Han-Chinese population.

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, P. R. China.

Immune-mediated quantitative and qualitative defects of hematopoietic stem/progenitor cells (HSPCs) play a vital role in the pathophysiology of acquired aplastic anemia (AA). Autophagy is closely related to T cell pathophysiology and the destiny of HSPCs, in which autophagy-related gene 5 (ATG5) is indispensably involved. We hypothesized that genetic variants of ATG5 might contribute to AA. Read More

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http://dx.doi.org/10.1002/jcb.28418DOI Listing
February 2019

Antidiabetic properties of aqueous and methanol extracts from the trunk bark of Ceiba pentandra in type 2 diabetic rat.

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon.

The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the combination of a high-fat diet (HFD) and a single dose of streptozotocin (40 mg/kg, intraperitoneal) at the seventh day of experimentation. Read More

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http://dx.doi.org/10.1002/jcb.28437DOI Listing
February 2019
3.263 Impact Factor

AMPA receptor expression in mouse testis and spermatogonial GC-1 cells: A study on its regulation by excitatory amino acids.

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

Department of Environmental, Biological, and Pharmaceutical Sciences & Technologies, University of Campania "L. Vanvitelli", Caserta, Italy.

Excitatory amino acids (EAAs) are found present in the nervous and reproductive systems of animals. Numerous studies have demonstrated a regulatory role for Glutamate (Glu), d-aspartate ( d-Asp) and N-methyl- d-aspartate (NMDA) in the control of spermatogenesis. EAAs are able to stimulate the Glutamate receptors, including the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR). Read More

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http://dx.doi.org/10.1002/jcb.28382DOI Listing
February 2019

PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-β1-induced EMT.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Cancer Hospital Affiliated of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.

Recent studies have demonstrated pleiotropic roles of pyruvate kinase isoenzyme type M2 (PKM2) in tumor progression. However, the precise mechanisms underlying the effects of PKM2 on esophageal squamous cell carcinoma (ESCC) metastasis and transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) remain to be established. In this study, we observed upregulation of PKM2 in ESCC tissues that was markedly associated with lymph node metastasis and poor prognosis. Read More

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http://dx.doi.org/10.1002/jcb.28434DOI Listing
February 2019

MSK2 promotes proliferation and tumor formation in squamous cervical cancer via PAX8/RB-E2F1/cyclin A2 axis.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, Heze Municipal Hospital, Heze, Shandong, China.

Patients with cervical cancer have abnormal cell proliferation and invasion after many years of latency. However, the precise mechanisms remain unclear. Mitogen- and stress-activated kinase 2 (MSK2) is a serine/threonine kinase which displays a phenotype that promotes tumor growth and metastasis in many different types of tumors. Read More

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http://dx.doi.org/10.1002/jcb.28421DOI Listing
February 2019

Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.

Metastasis is a key component of cancer progression and is strongly associated with poor prognosis. Perineural invasion is thought to be related to pain, tumor recurrence, and other conditions. However, the exact molecular mechanism is unclear. Read More

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http://dx.doi.org/10.1002/jcb.28457DOI Listing
February 2019

miR-939-5p decreases the enrichment of RNA polymerase II in the promoter region of CD2AP involved in nephrotic syndrome.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Pediatrics, the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.

The expression changes of CD2-associated protein (CD2AP) can lead to kidney diseases with proteinuria, including nephrotic syndrome (NS). A recent study reported that miRNAs may be important transcriptional regulators. In this study, we found increased expression of miR-939-5p and decreased expression of CD2AP in the peripheral blood of patients with NS. Read More

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http://dx.doi.org/10.1002/jcb.28413DOI Listing
February 2019
3.263 Impact Factor

Physiological functions of Wilms' tumor 1-associating protein and its role in tumourigenesis.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, P. R. China.

The Wilms' tumor-associated gene WT1 encodes a tumor suppressor gene, which is implicated in renal differentiation and development of adult urogenital system. Wilms' tumor 1-associating protein (WTAP) is initially identified as a nuclear protein that specifically interacts with WT1 in both in vitro and in vivo assays. WTAP is ubiquitously expressed in different tissues and various growth periods, and its expression is involved in cell cycle, RNA splicing and stabilization, N6-methyladenosine RNA modification, cell proliferation, and apoptosis as well as embryonic development. Read More

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http://dx.doi.org/10.1002/jcb.28402DOI Listing
February 2019
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Integrated analysis of competing endogenous RNA networks revealing five prognostic biomarkers associated with colorectal cancer.

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Department of Biotherapy, Beijing Hospital, National Center of Gerontology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Colorectal cancer (CRC) is a common malignant tumor with high morbidity and mortality around the world. The aim of this study was to determine the genes significantly associated with the overall survival (OS) of CRC patients and predict their function in the competing endogenous RNA (ceRNA) regulation networks. We constructed the lncRNA-miRNA-mRNA networks according to the differentially expressed RNAs from the The Cancer Genome Atlas data sets of 561 CRC patients. Read More

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http://dx.doi.org/10.1002/jcb.28403DOI Listing
February 2019

Identifying novel biomarkers in hepatocellular carcinoma by weighted gene co-expression network analysis.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.

Hepatocellular carcinoma (HCC) is a highly malignant tumor found in the bile duct epithelial cells, and the second most common tumor of the liver. However, the pivotal roles of most molecules of tumorigenesis in HCC are still unclear. Hence, it is essential to detect the tumorigenic mechanism and develop novel prognostic biomarkers for clinical application. Read More

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http://dx.doi.org/10.1002/jcb.28420DOI Listing
February 2019

The effects of adipose-derived stem cells on CD133-expressing bladder cancer cells.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Tissue Engineering, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine. They are also considered as a preferred cell source for urinary tract reconstruction. However, as MSCs exhibit affinity to tumor microenvironment, possible activation of tumor-initiating cells remains a major concern in the application of stem cell-based therapies for patients with a bladder cancer history. Read More

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http://doi.wiley.com/10.1002/jcb.28436
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http://dx.doi.org/10.1002/jcb.28436DOI Listing
February 2019
3 Reads

Electrospun triple-layered PLLA/gelatin. PRGF/PLLA scaffold induces fibroblast migration.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Tissue engineering and Applied Cell Sciences, School Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The function of fibroblast cells in wounded areas results in reconstruction of the extra cellular matrix and consequently resolution of granulation tissue. It is suggested that the use of platelet-rich plasma can accelerate the healing process in nonhealing or slow-healing wounds. In this study, a simple and novel method has been used to fabricate an electrospun three-layered scaffold containing plasma rich in growth factor with the aim of increasing the proliferation and migration of fibroblast cells in vitro. Read More

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http://dx.doi.org/10.1002/jcb.28422DOI Listing
February 2019
1 Read

Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales.

Retinoid X receptors (RXRs) belong to the nuclear receptor superfamily, and upon ligand activation, these receptors control gene transcription via either homodimerization with themselves or heterodimerization with the partner-nuclear receptor. The protective effects of RXRs and RXR agonists have been reported in several neurodegenerative diseases, including in the retina. This study was aimed to prioritize compounds from natural and synthetic origin retinoids as potential RXR agonists by molecular docking and molecular dynamic simulation strategies. Read More

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http://dx.doi.org/10.1002/jcb.28455DOI Listing
February 2019

Effect of cell source and osteoblast differentiation on gene expression profiles of mesenchymal stem cells derived from bone marrow or adipose tissue.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Mesenchymal stem cells (MSCs) have been used in therapies for bone tissue healing. The aim of this study was to investigate the effect of cell source and osteoblast differentiation on gene expression profiles of MSCs from bone marrow (BM-MSCs) or adipose tissue (AT-MSCs) to contribute for selecting a suitable cell population to be used in cell-based strategies for bone regeneration. BM-MSCs and AT-MSCs were cultured in growth medium to keep MSCs characteristics or in osteogenic medium to induce osteoblast differentiation (BM-OBs and AT-OBs). Read More

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http://dx.doi.org/10.1002/jcb.28463DOI Listing
February 2019

Gain of native conformation of Aurora A S155R mutant by small molecules.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, Himachal Pradesh, India.

Aurora A is a mitotic serine/threonine kinase protein that is a proposed target of the first-line anticancer drug design. It has been found to be overexpressed in many human cancer cells, including hematological, breast, and colorectal. Here, we focus on a particular somatic mutant S155R of Aurora kinase A protein, whose activity decreases because of loss of interaction with a TPX2 protein that results in ectopic expression of the Aurora kinase A protein, which contributes chromosome instability, centrosome amplification, and oncogenic transformation. Read More

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http://dx.doi.org/10.1002/jcb.28387DOI Listing
February 2019

Osteogenesis inducers promote distinct biological responses in aortic and mitral valve interstitial cells.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Chemical Engineering, Texas Tech University, Lubbock, Texas.

Both aortic and mitral valves calcify in pathological conditions; however, the prevalence of aortic valve calcification is high whereas mitral valve leaflet calcification is somewhat rare. Patterns of valvular calcification may differ due to valvular architecture, but little is known to that effect. In this study, we investigated the intrinsic osteogenic differentiation potential of aortic versus mitral valve interstitial cells provided minimal differentiation conditions. Read More

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http://dx.doi.org/10.1002/jcb.28392DOI Listing
February 2019

Downregulation of miroRNA-141 mediates acquired resistance to trastuzumab and is associated with poor outcome in breast cancer by upregulating the expression of ERBB4.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Breast Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, P. R. China.

Background: microRNAs are involved in the control of cell growth and apoptosis; they also play an essential role in resistance towards trastuzumab, in breast cancer. The objective of this study was to identify differentially expressed microRNA(s) and explore its therapeutic role in treatment of the disease.

Methods: Real-time polymerase chain reaction (RT-PCR) was performed to identify the virtual microRNA (miRNA) involved in breast cancer cells resistant to trastuzumab. Read More

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http://dx.doi.org/10.1002/jcb.28416DOI Listing
February 2019
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Role of Akirin1 in the regulation of skeletal muscle fiber-type switch.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Molecular Oncology, MVR Cancer Center and Research Institute, Kozhikode, India.

Akirin1 is a highly conserved ubiquitously expressed nuclear protein. Owing to its strong nuclear localization signal and protein-protein interaction properties, Akirin1 has been speculated to regulate transcription of target genes as a cofactor. Previous studies have reported Akirin1 as a downstream target of myostatin, a potent negative regulator of myogenesis. Read More

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http://dx.doi.org/10.1002/jcb.28406DOI Listing
February 2019

Artemisinin inhibits angiogenesis by regulating p38 MAPK/CREB/TSP-1 signaling pathway in osteosarcoma.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Orthopedics, Shanghai Songjiang Central Hospital, Shanghai, China.

Osteosarcoma is the most common bone tumor and characterizes a high metastatic potential. In osteosarcoma, angiogenesis is reported to be closely associated with tumor metastasis. Understanding the underlying mechanisms and accordingly developing therapeutic strategies are urgently desired. Read More

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http://dx.doi.org/10.1002/jcb.28424DOI Listing
February 2019

Molecular interaction of investigational ligands with human brain acetylcholinesterase.

Authors:
Shazi Shakil

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Alzheimer's disease, a neurodegenerative disorder continues to be an area of investigation by the international researchers' fraternity. Despite all the ongoing efforts, the effective set of promising cholinesterase inhibitors available in the market for patients' use is limited. Furthermore, the currently available drugs could provide only a palliative type of treatment instead of providing a complete cure or foolproof prevention. Read More

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http://dx.doi.org/10.1002/jcb.28461DOI Listing
February 2019
1 Read

miR-210 inhibits cell migration and invasion by targeting the brain-derived neurotrophic factor in glioblastoma.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.

Recently, there is increasing evidence that microRNAs are related to the development, diagnosis, treatment, and prognosis of glioblastoma. microRNA-210 (miR-210) had been identified in many human cancers, but the specific function of miR-210 remains unclear in glioblastoma. The present study mainly focused on exploring its biological role and potential molecular mechanisms in glioblastoma. Read More

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http://dx.doi.org/10.1002/jcb.28414DOI Listing
February 2019
3.263 Impact Factor

Cell-specific elevation of Runx2 promotes hepatic infiltration of macrophages by upregulating MCP-1 in high-fat diet-induced mice NAFLD.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: We have demonstrated runt-related transcription factor 2 (Runx2) plays important role in atherosclerosis. It has been indicated that atherosclerosis shares the similar histopathology with nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), on macrophages infiltration. However, the function of Runx2 in NAFLD is completely unknown. Read More

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http://doi.wiley.com/10.1002/jcb.28456
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http://dx.doi.org/10.1002/jcb.28456DOI Listing
February 2019
1 Read

Interleukin-17A-mediated alleviation of cortical astrocyte ischemic injuries affected the neurological outcome of mice with ischemic stroke.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurobiology and Center of Stroke, Beijing Institute for Brain Disorders, School of Basic Medical Science, Capital Medical University, Beijing, China.

We previously reported that astrocytes are the main sources of interleukin (IL)-17A production that could aggravate neuronal injuries in ischemic stroke. However, the effects of IL-17A on ischemic astrocytes themselves and the underlying molecular mechanism are still unclear. In this study, we found that recombinant mouse (rm) IL-17A could significantly (P < 0. Read More

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http://dx.doi.org/10.1002/jcb.28429DOI Listing
February 2019

Elevated expression of the V-ATPase D2 subunit triggers increased energy metabolite levels in Kras -driven cancer cells.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Biological Sciences, College of Life Sciences, North China University of Science and Technology, Tangshan, Hebei, China.

Mutations of the Ras oncogene are frequently detected in human cancers. Among Ras-mediated tumorigenesis, Kras-driven cancers are the most dominant mutation types. Here, we investigated molecular markers related to the Kras mutation, which is involved in energy metabolism in Kras mutant-driven cancer. Read More

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http://dx.doi.org/10.1002/jcb.28448DOI Listing
February 2019

Improved chondrogenic response of mesenchymal stem cells to a polyethersulfone/polyaniline blended nanofibrous scaffold.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Owing to the fact that the cartilage tissue is not able to repair itself, the treatment of the joint damages is very difficult by current methods. Induction of tissue repair requires suitable cell and extracellular matrix. Providing these two parts can only be done using tissue engineering. Read More

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http://dx.doi.org/10.1002/jcb.28412DOI Listing
February 2019

Evaluation of prognostic usefulness of long noncoding RNA GAS5 and FAL1 in papillary thyroid carcinoma.

J Cell Biochem 2019 Feb 11. Epub 2019 Feb 11.

Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran.

Genetic studies on cancers have revealed that lncRNA-GAS5 and lncRNA-FAL1 are overexpressed in some cancerous cells. The aim of the present investigation was to evaluate the roles of lncRNA-GAS5 and lncRNA-FAL1 gene expression changes in the diagnosis and prognosis of patients with papillary thyroid carcinoma (PTC). In a case-control investigation, we recruited a total of 140 formalin-fixed paraffin-embedded tissues of PTC, including 70 cancerous and noncancerous tissues. Read More

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http://dx.doi.org/10.1002/jcb.28425DOI Listing
February 2019

Long noncoding RNA HOXD-AS1 induces epithelial-mesenchymal transition in breast cancer by acting as a competing endogenous RNA of miR-421.

J Cell Biochem 2019 Feb 7. Epub 2019 Feb 7.

Department of Ultrasonic Diagnosis, The First Affiliated Hospital of China Medical University, Shenyang City, Liaoning, People's Republic of China.

Breast cancer (BCa) is the most common malignant tumor in females. Long noncoding RNAs (lncRNAs) are deregulated in many types of human cancers, including BCa. The purpose of the present study was to examine the expression profile and biological role of HOXD cluster antisense RNA 1 (HOXD-AS1) in BCa. Read More

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http://dx.doi.org/10.1002/jcb.28353DOI Listing
February 2019

Chinese herbal medicines of supplementing Qi and nourishing Yin combined with chemotherapy for non-small cell lung cancer: A meta-analysis and systematic review.

J Cell Biochem 2019 Feb 7. Epub 2019 Feb 7.

Department of Respiratory Medicine, Nantong Third People's Hospital, Nantong, Jiangsu, China.

Background: Non-small cell lung cancer (NSCLC) is one of the malignant tumors with the highest incidence and mortality. This meta-analysis aimed to explore the efficacy of the supplementing Qi and nourishing Yin method combined with chemotherapy for the treatment of NSCLC based on qualified randomized controlled trials.

Method: PubMed, Cochrane, and Embase databases were searched by the index words to identify the eligible studies, and relevant literature sources were also searched. Read More

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http://doi.wiley.com/10.1002/jcb.28192
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http://dx.doi.org/10.1002/jcb.28192DOI Listing
February 2019
2 Reads

Substance P inhibits high urea-induced apoptosis through the AKT/GSK-3β pathway in human corneal epithelial cells.

J Cell Biochem 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

To investigate the effect of substance P (SP) on human corneal epithelial cells (HCECs) that have been stressed by a high urea environment and to determine the relationship between SP and the protein kinase B (AKT)/glycogen synthase kinase-3β (GSK-3β) signaling pathway. An in vitro model of chronic renal failure (CRF)-related dry eye was used to study HCECs that were treated with high urea concentrations. Cell proliferation was assayed using a cell counting kit-8 test. Read More

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http://dx.doi.org/10.1002/jcb.28410DOI Listing
February 2019
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Anti-colorectal cancer targets of resveratrol and biological molecular mechanism: Analyses of network pharmacology, human and experimental data.

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Department of Pharmacology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.

In this study, colorectal cancer (CRC)-diseased targets and resveratrol (Res)-associated targets were combined and constructed by the use of grouped databases for identification of the predicted targets. After production of target-functional protein interaction network of Res anti-CRC, the topological analysis was used to create the core targets of Res anti-CRC. All core targets performed the analyses of biological function and pathway enrichment to optimize the biological processes and key signaling pathways of Res anti-CRC. Read More

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http://dx.doi.org/10.1002/jcb.28404DOI Listing
February 2019
1 Read
3.263 Impact Factor

Effects of CPAP on the transcriptional signatures in patients with obstructive sleep apnea via coexpression network analysis.

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Department of Orthodontics, Guiyang Hospital of Stomatology, Guiyang, China.

A growing number of studies provide epidemiological evidence linking obstructive sleep apnea (OSA) with a number of chronic disorders. Transcriptional analyses have been conducted to analyze the gene expression data. However, the weighted gene coexpression network analysis (WGCNA) method has not been applied to determine the transcriptional consequence of continuous positive airway pressure (CPAP) therapy in patients with severe OSA. Read More

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http://dx.doi.org/10.1002/jcb.28203DOI Listing
February 2019
1 Read

C1qTNF-related protein-6 protects against doxorubicin-induced cardiac injury.

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.

The clinical use of doxorubicin (DOX) is limited by its toxic effect. However, there is no specific drug that can prevent DOX-related cardiac injury. C1qTNF-related protein-6 (CTRP6) is a newly identified adiponectin paralog with many protective functions on metabolism and cardiovascular diseases. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28366
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http://dx.doi.org/10.1002/jcb.28366DOI Listing
February 2019
2 Reads

Erlotinib inhibits colon cancer metastasis through inactivation of TrkB-dependent ERK signaling pathway.

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Department of Colorectal Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

The distal metastasis is the main cause of death in patients with colon cancer. Tyrosine receptor kinase B (TrkB) and ERK signals may be the potential targets for the treatment of colon cancer metastasis. This study aims to investigate whether erlotinib inhibits distant metastasis of colon cancer by regulating TrkB and ERK signaling pathway. Read More

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http://dx.doi.org/10.1002/jcb.28400DOI Listing
February 2019
2 Reads

Enhanced expression of circ_0000267 in hepatocellular carcinoma indicates poor prognosis and facilitates cell progression by sponging miR-646.

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Department of Radiology, Hongqi Affiliated Hospital of Mudanjiang Medical University, Mudanjiang, China.

Hepatocellular carcinoma (HCC) is a highly aggressive carcinoma worldwide. Circular RNAs (circRNAs) have been proved to be involved in the pathogenesis of several carcinomas. circ_0000267 was reported to be elevated in HCC tissue samples by circRNA microarray. Read More

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http://dx.doi.org/10.1002/jcb.28411DOI Listing
February 2019

Emerging roles of microRNAs in regulating the mTOR signaling pathway during tumorigenesis.

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

The mammalian target of rapamycin (mTOR) is a large Ser/Thr protein kinase that belongs to the phosphoinositide 3-kinase (PI3K) family and mediates various physiological and pathological processes, especially cell proliferation, protein synthesis, autophagy, and cancer development. The mTOR expression is transient and tightly regulated in normal cells, but it is overactivated in cancer cells. Recently, several studies have indicated that microRNAs (miRNAs) play a critical role in the regulation of mTOR and mTOR-associated processes, some acting as inhibitors and the others as activators. Read More

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http://dx.doi.org/10.1002/jcb.28401DOI Listing
February 2019

Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker-256 tumor-bearing rats.

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Department of Physiological Sciences, State University of Londrina, Londrina, Paraná, Brazil.

Gluconeogenesis (GN) is increased in patients with cancer cachexia, but is reduced in liver perfusion of Walker-256 tumor-bearing cachectic rats (TB rats). The causes of these differences are unknown. We investigated the influence of circulating concentrations of lactate (NADH generator) and NADH on GN in perfused livers of TB rats. Read More

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http://dx.doi.org/10.1002/jcb.28384DOI Listing
February 2019
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Computational and mutational analysis of TatD DNase of Bacillus anthracis.

J Cell Biochem 2019 Feb 5. Epub 2019 Feb 5.

Laboratory of Molecular Biology and Genetic Engineering, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.

The role of TatD DNases as DNA repair enzymes or cell death (apoptotic) nucleases is well established in prokaryotes as well as eukaryotes. The current study aims to characterize the TatD nuclease from Bacillus anthracis (Ba TatD) and to explore its key histidine catalytic residues. Ba TatD was found to be a metal-dependent, nonspecific endonuclease which could efficiently cleave double-stranded DNA substrates. Read More

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http://dx.doi.org/10.1002/jcb.28408DOI Listing
February 2019

Generation of Fam83h knockout mice by CRISPR/Cas9-mediated gene engineering.

J Cell Biochem 2019 Feb 3. Epub 2019 Feb 3.

Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Family with sequence similarity 83 member H (FAM83H) protein-coding geneplay an essential role in the structural organization, calcification of developing enamel, and keratin cytoskeleton disassembly by recruiting Casein kinase 1 alpha (CSNK1A1) to keratin filaments. In this study, we have applied CRISPR Cas9 nickase (D10A) to knockout (KO) the Fam83h gene in NMRI outbred mice. We generated homozygous Fam83h KO mice ( Fam83h ) through a premature termination codon, which was validated by Sanger sequencing in F0 generation. Read More

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http://doi.wiley.com/10.1002/jcb.28381
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http://dx.doi.org/10.1002/jcb.28381DOI Listing
February 2019
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Six-transmembrane epithelial antigen of the prostate 1 is associated with tumor invasion and migration in endometrial carcinomas.

J Cell Biochem 2019 Feb 3. Epub 2019 Feb 3.

Department of Maternal and Child Health, School of Public Health, Shandong University, Jinan, China.

Six-transmembrane epithelial antigen of the prostate 1 (STEAP1), a member of the STEAP family, is a general tumor antigen. However, no information has been available to date regarding the function of STEAP1 in the progression of endometrial carcinoma. In this study, we used in vitro and in vivo strategies to prove that STEAP1 plays an important role in the progression of endometrial carcinoma. Read More

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http://dx.doi.org/10.1002/jcb.28393DOI Listing
February 2019
1 Read

Complications of nonionizing radiofrequency on divided attention.

J Cell Biochem 2019 Feb 3. Epub 2019 Feb 3.

Department of Psychology, Payame Noor University (PNU), Iran.

Exposure to electromagnetic fields is considered as a potential hazard for biological systems. The objective of our investigation is the study of probable consequences of radiofrequency electromagnetic fields from Wi-Fi router devices on the short-term memory, and attention's levels. A population consisting of 312 female college students (14 to 17 years old) was elected by cluster random sampling. Read More

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http://dx.doi.org/10.1002/jcb.28343DOI Listing
February 2019

Inhibition of apoptosis via CHIP-mediated proteasomal degradation of TAp73α.

J Cell Biochem 2019 Feb 3. Epub 2019 Feb 3.

School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.

TAp73, a homologous of tumor suppressor p53, regulates apoptosis in a p53-independent manner and its suppressive as well as stimulatory role in promoting angiogenesis has been reported. It exists in multiple isoforms which varies structurally in their N-terminus and C-terminus region and crucial interplay among them guides the decision of cell survival and death. As molecular chaperones control both stability and degradation of TAp73, selective regulation of p73 isoforms has implication upon developing new therapeutic for hypoxic tumor. Read More

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http://dx.doi.org/10.1002/jcb.28386DOI Listing
February 2019

Protective effect of Abutilon indicum against lead-induced reproductive toxicity in male Wistar rats.

J Cell Biochem 2019 Feb 3. Epub 2019 Feb 3.

Department of Biomedical Sciences, School of Biosciences and Technology, VIT, Vellore, Tamil Nadu, India.

Despite ample literature on the toxic impact of lead on the environment and health, the exact mechanism of pathogenesis/toxicity is not clearly known. Because it is well established that lead induces oxidative stress, it is assumed that exposure to antioxidants may reduce the toxic impact of lead. In this study, we evaluated the impact of coadministration of the methanolic root extract of a plant Abutilon indicum (50, 100, 200 mg kg b. Read More

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http://dx.doi.org/10.1002/jcb.28395DOI Listing
February 2019
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The enigmatic role of matrix metalloproteinases in epithelial-to-mesenchymal transition of oral squamous cell carcinoma: Implications and nutraceutical aspects.

J Cell Biochem 2019 Feb 3. Epub 2019 Feb 3.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

The most prevalent malignancy in the oral cavity is represented by oral squamous cell carcinoma, an aggressive disease mostly detected in low-income communities. This neoplasia is mostly diffused in older men particularly exposed to risk factors such as tobacco, alcohol, and a diet rich in fatty foods and poor in vegetables. In oral squamous cell carcinoma, a wide range of matrix-cleaving proteinases are involved in extracellular matrix remodeling of cancer microenvironment. Read More

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http://dx.doi.org/10.1002/jcb.26905DOI Listing
February 2019
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