12,116 results match your criteria Journal of Cellular Biochemistry [Journal]


miR-188-5p emerges as an oncomiRNA to promote gastric cancer cell proliferation and migration via upregulation of SALL4.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.

MicroRNAs (miRNAs) play pivotal roles in modulating key biological processes in gastric cancer (GC). As a newly identified miRNA, the function and potential mechanism of miR-188-5p in GC has not been thoroughly elucidated. Here, quantitative real-time polymerase chain reaction detection showed abnormally higher expression of miR-188-5p in GC cells and tissues. Read More

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http://dx.doi.org/10.1002/jcb.28764DOI Listing

Sapylin inhibits lung cancer cell proliferation and promotes apoptosis by attenuating PI3K/AKT signaling.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Department of Respiratory Medicine, Dongying People's Hospital, Dongying, Shandong, China.

Sapylin (OK-432) revealed biological properties in cancers. In this study, the effect of sapylin on lung cancer cell A549 was investigated. A549 cell lines were treated with sapylin (0. Read More

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http://dx.doi.org/10.1002/jcb.28729DOI Listing

SP1 regulates KLF4 via SP1 binding motif governed by DNA methylation during odontoblastic differentiation of human dental pulp cells.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Objective: DNA methylation is a critical epigenetic modulation in regulating gene expression in cell differentiation process, however, its detailed molecular mechanism during odontoblastic differentiation remains elusive. We aimed to study the global effect of DNA methylation on odontoblastic differentiation and how DNA methylation affects the transactivation of transcription factor (TF) on its target gene.

Methods: DNA methyltransferase (DNMTs) inhibition assay and following odontoblastic differentiation assay were performed to evaluate the effect of DNA methylation inhibition on odontoblastic differentiation. Read More

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http://dx.doi.org/10.1002/jcb.28730DOI Listing

Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.

The present study aimed to evaluate the potential therapeutic effect of pantoprazole, a proton-pump inhibitor, on precancerous lesion (PCL) in rats. diethylnitrosamine and 2-acetylaminofluorene were used to induce PCL in rats, in vivo. The rats were treated with three doses of pantoprazole (100, 50, and 25  mg/kg; three times weekly) during the last 4 weeks of the total 10 weeks of the experiment. Read More

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http://dx.doi.org/10.1002/jcb.28757DOI Listing

Integrative analysis of transcriptome-wide association study data and messenger RNA expression profiles identified candidate genes and pathways for inflammatory bowel disease.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.

Inflammatory bowel disease (IBD) is a complex disease, resulting from abnormal immune response to intestinal tract microbiota in genetically susceptible individuals. Crohn's disease and ulcerative colitis (UC) are the two major types of IBD. Transcriptome-wide association study (TWAS) of IBD was first performed using a large-scale genome-wide association study summary data sets of IBD. Read More

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http://dx.doi.org/10.1002/jcb.28744DOI Listing
April 2019
1 Read

Organochlorine and organophosphorus pesticides and bladder cancer: A case-control study.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Background: Exposure to pesticides is associated with an increase in the incidence of cancer. We aimed to investigate the association of serum organochlorine pesticides (OCPs) and organophosphorus pesticides (OPs) levels and GSTM1/GSTT1 gene polymorphism with bladder cancer (BC).

Methods: This study was performed on 57 patients with BC and 30 controls (C). Read More

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http://dx.doi.org/10.1002/jcb.28746DOI Listing

Methyl helicterate inhibits hepatic stellate cell activation through downregulating the ERK1/2 signaling pathway.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Life Sciences Institute and Pharmaceutical College, Guangxi Medical University, Nanning, China.

The present study was to investigate the inhibitory effect of methyl helicterate (MH) on hepatic stellate cells (HSC-T6), primarily elucidating the underlying mechanism of MH against liver fibrosis. HSC-T6 cells were activated by platelet-derived growth factor (PDGF) stimulation, and then the effects of MH on cell viability, cytomembrane integrity, colony, migration, apoptosis, and cell cycle were detected. Moreover, the regulative mechanism of MH on HSCs was investigated by detecting the activation of the extracellular signal-regulated kinase (ERK1/2) signaling pathway. Read More

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http://dx.doi.org/10.1002/jcb.28756DOI Listing

Hypoxia inducible factor-1 promotes liver fibrosis in nonalcoholic fatty liver disease by activating PTEN/p65 signaling pathway.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Department of Endocrinology and Metabolism, Qingdao Haici Hospital, Qingdao, Shandong, China.

Obesity is a major contributor to the development of steatohepatitis and fibrosis from nonalcoholic fatty liver disease (NAFLD). Hypoxia aggravates progression of NAFLD. In mice on high-fat diet (HFD), hepatic steatosis leads to liver tissue hypoxia, evidenced by accumulation of hypoxia inducible factor-1-alpha (HIF-1α), which is a central regulator of the global response to hypoxia. Read More

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http://dx.doi.org/10.1002/jcb.28734DOI Listing

The expression of long non coding RNA genes is associated with expression with polymorphisms of HULC rs7763881 and MALAT1 rs619586 in hepatocellular carcinoma and HBV Egyptian patients.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Long noncoding RNAs (lncRNAs), highly upregulated liver cancer (HULC), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), lncRNA-AF085935, and lncRNA-uc003wbd have been implicated in hepatocellular carcinoma (HCC). Single-nucleotide polymorphism (SNP) in HULC and MALAT1 are associated with HCC susceptibility. However, association between these SNPs and lncRNA-AF085935 and lncRNA-uc003wbd expression and their potential clinical value in differentiating HCC from both hepatitis B virus (HBV)-infected Egyptian patients and the healthy specimens have not been explored yet. Read More

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http://dx.doi.org/10.1002/jcb.28726DOI Listing
April 2019
3.263 Impact Factor

Genetic variants of TSPAN12 gene in patients with retinopathy of prematurity.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Medical University, TianJin, PR China.

Genetic susceptibility to retinopathy of prematurity (ROP) has been reported. However, no virulence genes are currently known for ROP. This study aimed to assess FZD4, LRP5, TSPAN12, and NDP, which are known virulence genes involved in familial exudative vitreoretinopathy, an ailment that shares some symptoms with ROP. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28715
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http://dx.doi.org/10.1002/jcb.28715DOI Listing
April 2019
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Eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through AKT/FOXO1 signaling.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Dermatology department, Shaanxi hospital of traditional Chinese medicine, Xi'an, China.

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one (eriodictyol), a flavonoid compound, was proved to possess anti-inflammatory, antioxidative, and antiarthritis activities. However, the effects of eriodictyol on the rheumatoid proliferation, apoptosis, and inflammatory response of arthritis fibroblast-like synoviocytes (RA-FLS) remain unclear. Thus, the objective of this study was to examine the effects of eriodictyol on RA-FLS survival, apoptosis, and inflammatory response, and further explore the potential underlying mechanisms. Read More

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http://dx.doi.org/10.1002/jcb.28724DOI Listing

Low-intensity pulsed ultrasound promotes bone morphogenic protein 9-induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho-associated kinase 1 in human periodontal ligament fibroblasts.

J Cell Biochem 2019 Apr 21. Epub 2019 Apr 21.

Department of Oral Biochemistry, Field of Developmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Periodontal ligament fibroblasts (PDLFs) have osteogenic capacity, producing bone matrix proteins. Application of bone morphogenic proteins (BMPs) to PDLFs is a promising approach for periodontal regeneration. However, in chronic bone metabolic disorders, such as periodontitis, proper control of accompanying inflammation is essential for optimizing the effects of BMPs on PDLFs. Read More

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http://dx.doi.org/10.1002/jcb.28727DOI Listing

The interplay between microbiota-dependent metabolite trimethylamine N-oxide, Transforming growth factor β/SMAD signaling and inflammasome activation in chronic kidney disease patients: A new mechanistic perspective.

J Cell Biochem 2019 Apr 19. Epub 2019 Apr 19.

Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: Chronic kidney disease (CKD) signifies a frequently life-threatening condition influencing kidney structure and function. Despite its irrefutable importance, its exact pathogenesis is not completely clarified. However, CKD is known to be associated with accumulated uremic toxins/metabolites, interstitial fibrosis, and systemic inflammation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28707
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http://dx.doi.org/10.1002/jcb.28707DOI Listing
April 2019
1 Read

miR-143 inhibits proliferation and metastasis of nasopharyngeal carcinoma cells via targeting FMNL1 based on clinical and radiologic findings.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

CT/MRI Department, Xingtai People's Hospital, Hebei, China.

Mounting evidence has reported that microRNA-143 (miR-143) is involved in the development of multiple cancers. To investigate the underlying mechanisms of miR-143 regulating proliferation and metastasis in nasopharyngeal carcinoma (NPC) cells, we evaluated the levels of miR-143 and formin-like protein 1 (FMNL1) in NPC tissues. The results of qRT-PCR and Western blot analysis showed that the expression of miR-143 was decreased, while FMNL1 was increased in NPC tissues. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28709
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http://dx.doi.org/10.1002/jcb.28709DOI Listing
April 2019
2 Reads

Astragaloside attenuates lipopolysaccharide-induced cell apoptosis in human gingiva cells via MAPK signaling pathway.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, China.

Subjects: The aim of this study was to research the antiapoptotic effect of astragaloside, the principal component of Astragalus membranaceus (Fisch) Bge, in human gingiva cells induced by lipopolysaccharide (LPS).

Methods: According to the treatment, human gingiva cells were divided into five groups, including (1) control group without drug treatment; (2) imitating group, treated with LPS (10 μg·mL ) alone; (3) low group, treated with LPS and 50 μmol·L astragaloside; (4) medium group, treated with LPS and 100 μmol·L astragaloside; and (5) high group, treated with LPS and 150 μmol·L astragaloside. Cell proliferation and apoptosis were investigated using MTT assay and flow cytometry, respectively. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28286
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http://dx.doi.org/10.1002/jcb.28286DOI Listing
April 2019
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Overexpression miR-24-3p repressed Bim expression to confer tamoxifen resistance in breast cancer.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Ultrasonic Diagnosis, the First Affiliated Hospital of China Medical University, Shenyang, China.

Endocrine therapy resistance represents a major challenge to the successful treatment of patients with breast cancer. The development of tamoxifen resistance commonly occurrs during the treatment of patients with breast cancer whereas its underlying mechanisms remain elusive. Here, we found that miR-24-3p regulated tamoxifen sensitivity in breast cancer cells. Read More

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http://dx.doi.org/10.1002/jcb.28568DOI Listing

A noncoding RNA LINC00504 interacts with c-Myc to regulate tumor metabolism in colon cancer.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

Department of General Surgery, Minhang Hospital, Fudan University, Shanghai, China.

Accumulating evidence has shown a critical role of long-non-coding RNAs (lncRNAs) during multiple tumor progression. However, the potential functions of LINC00504 in colon cancer as well as its mechanisms remain obscure. By lncRNA profiling, we identified LINC00504 as a novel oncogenic lncRNA in colon cancer. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28733
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http://dx.doi.org/10.1002/jcb.28733DOI Listing
April 2019
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Isolation and characterization of a novel scFv antibody fragments specific for Hsp70 as a tumor biomarker.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Many studies have shown that more than 50% of tumors express heat shock protein 70 kDa (Hsp70) at the plasma membrane surface while not seen in normal cells, therefore it is a promising therapeutic target in human cancers. Hence, we used phage display technology to produce a single-chain fragment variable (scFv) antibody against human Hsp70. For this, a target peptide from human Hsp70 was designed using bioinformatics studies and was chemically synthesized. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28732
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http://dx.doi.org/10.1002/jcb.28732DOI Listing
April 2019
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Annexin A3 depletion overcomes resistance to oxaliplatin in colorectal cancer via the MAPK signaling pathway.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.

Colorectal cancer (CRC) is a common disease with high mortality and morbidity. Annexin A3 (ANXA3) belongs to the structurally homologous family of Ca and phospholipid-binding proteins. This study aimed to investigate the effects and potential mechanisms of ANXA3 on oxaliplatin (Ox) resistance in CRC. Read More

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http://dx.doi.org/10.1002/jcb.28720DOI Listing

Identification of natural compound inhibitors against PfDXR: A hybrid structure-based molecular modeling approach and molecular dynamics simulation studies.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Centre for Applied Chemistry, Central University of Gujarat, Gandhinagar, Gujarat, India.

In the present contribution, multicomplex-based pharmacophore studies were carried out on the structural proteome of Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Among the constructed models, a representative model with complementary features, accountable for the inhibition was used as a primary filter for the screening of database molecules. Auxiliary evaluations of the screened molecules were performed via drug-likeness and molecular docking studies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28714
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http://dx.doi.org/10.1002/jcb.28714DOI Listing
April 2019
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The effects of parathyroid hormone-related peptide on cardiac angiogenesis, apoptosis, and function in mice with myocardial infarction.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

It is known that parathyroid hormone-related peptide (PTHrP) contains a nuclear localization sequence (NLS, 87-107), which, together with its C-terminus (107-139), has been shown to positively regulate vascular smooth muscle cell (VSMCs) proliferation and vascular neointima formation, and inhibit cellular apoptosis. The role of PTHrP in ischemic cardiac diseases remains unclear. In this study, we attempted to determine whether PTHrP 87 to 139 can play a role in promoting cardiac function via enhancing angiogenesis after myocardial infarction (MI) occurred. Read More

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http://dx.doi.org/10.1002/jcb.28735DOI Listing

Silencing of microRNA-27a facilitates autophagy and apoptosis of melanoma cells through the activation of the SYK-dependent mTOR signaling pathway.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, P.R. China.

Melanoma is considered as an aggressive neoplastic transformation and featured with high metastatic potential. Although some studies have provided targets for novel therapeutic interventions, clinical development of targeted drugs for melanoma still remains obscure. Therefore, this study aims to identify the role of microRNA-27a (miR-27a) in autophagy and apoptosis of melanoma cells in regulating spleen tyrosine kinase (SYK)-mediated the mammalian target of rapamycin (mTOR) signaling pathway. Read More

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http://dx.doi.org/10.1002/jcb.28600DOI Listing

Radiosynthesis, radiochemical, and biological characterization of Lu-labeled diethylenetriamine penta-acetic acid.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences, Islamabad, Pakistan.

Diethylenetriamine penta-acetic acid (DTPA), when complexed with a gamma (γ)-emitter radioisotope like Tc, is used for renal function diagnosis and many other diagnostic applications. The main aim of this study was to develop a novel and versatile single-step methodology for the synthesis of a new Lu-labeled radiopharmaceutical with high radiochemical yield, which can be used for diagnostic purposes and therapeutic purposes also. The single and well-defined Lu-DTPA complex was radiochemically characterized by paper chromatography, thin-layer chromatography, high-performance liquid chromatography, and electrophoresis techniques. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28712
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http://dx.doi.org/10.1002/jcb.28712DOI Listing
April 2019
1 Read
3.263 Impact Factor

GLP-1 induces alpha cell proliferation and overrides leptin suppression induced by negative energy balance in vagotomized rats.

J Cell Biochem 2019 Apr 17. Epub 2019 Apr 17.

Endocrine, Cardiovascular & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.

Glucagon-like peptide-1 (GLP-1) influences energy balance by exerting effects on food intake and glucose metabolism, through mechanisms that are partially dependent on the vagal pathway. The aim of this study was to characterize the effects of chronic GLP-1 stimulation on energy homeostasis and glucose metabolism in the absence of vagal innervation Truncal vagotomized (VGX) and sham operated rats (SHAM) received an intraperitoneal GLP-1 infusion (3.5 pmol/kg/min) trough mini-osmotic pumps. Read More

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http://dx.doi.org/10.1002/jcb.28719DOI Listing
April 2019
1 Read

Upregulation of hsa_circ_0136666 contributes to breast cancer progression by sponging miR-1299 and targeting CDK6.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Department of Oncology, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, 62 South Huaihai Rode, Huai'an, China.

Circular RNAs (circRNAs) can participate in multiple cancers, including breast cancer. Increasing circRNAs are recognized in various cancers because of the high-throughput sequencing. However, the potential physiological effect of hsa_circ_0136666 in breast cancer progression is unknown. Read More

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http://dx.doi.org/10.1002/jcb.28536DOI Listing

Investigating the diagnostic performance of HOTTIP, PVT1, and UCA1 long noncoding RNAs as a predictive panel for the screening of colorectal cancer patients with lymph node metastasis.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, hahid Beheshti University of Medical Sciences, Tehran, Iran.

Like other noncoding RNAs (ncRNAs), dysregulation of long ncRNAs (lncRNAs) has been associated with various clinicopathological features of colorectal cancer (CRC) patients such as lymph node metastasis (LNM). Recently, three aberrant expressed oncogenic lncRNA (onco-lncRNAs), including HOXA transcript at the distal tip (HOTTIP), plasmacytoma variant translocation 1 (PVT1), and urothelial carcinoma associated 1 (UCA1) have been reported in LNM. Herein, we compared the diagnostic performance of these lncRNAs as individual biomarkers and as a discriminating panel between LNM CRC patients, nonmetastatic lymph nodes (NLN) and normal healthy subjects. Read More

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http://dx.doi.org/10.1002/jcb.28739DOI Listing
April 2019
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lncRNA TINCR participates in ALA-PDT-induced apoptosis and autophagy in cutaneous squamous cell carcinoma.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, People's Hospital of Henan Province, Zhengzhou, Henan, China.

This study aims to investigate whether terminal differentiation-induced ncRNA (TINCR) has an effect on apoptosis and autophagy induced by ALA-PDT in cutaneous squamous cell carcinoma (CSCC). A431 cells were treated with 5-aminolevulinic acid (ALA) solution at different concentrations and for different duration time. A431 cell viability was detected by Cell Counting Kit-8 (CCK-8) assay, relative TINCR messenger RNA expression was detected by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1002/jcb.28662DOI Listing

Long noncoding RNA HOXA-AS2 regulates the expression of SCN3A by sponging miR-106a in breast cancer.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Shanghai Research Center of Biliary Tract Disease, Shanghai, China.

Breast cancer is the most commonly diagnosed cancer that affects women worldwide. This study aimed to investigate the competing endogenous RNAs (ceRNAs) mechanism in breast cancer. Microarray data were downloaded from the University of California Santa Cruz (UCSC) Xena database. Read More

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http://dx.doi.org/10.1002/jcb.28706DOI Listing

microRNA-193b protects against myocardial ischemia-reperfusion injury in mouse by targeting mastermind-like 1.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Department of Cardiovascular Medicine, Linyi Central Hospital, Linyi, Shandong, China.

The current study aimed to explore the functions and roles of microRNA-193b (miR-193b) in the myocardium with ischemia-reperfusion (I/R) injury and a potential therapeutic method for myocardial I/R injury. The mice were subjected to myocardial I/R with or without miR-193b pretreatment. The infarct size and myocardial enzymes were detected. Read More

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http://dx.doi.org/10.1002/jcb.28684DOI Listing

Identification of Nrf2/STAT3 axis in induction of apoptosis through sub-G cell cycle arrest mechanism in HT-29 colon cancer cells.

J Cell Biochem 2019 Apr 16. Epub 2019 Apr 16.

Department of Molecular Medicine, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.

We investigated the role of stattic as an adjuvant molecule to increase the cytotoxicity of 5-fluorouracil (5-FU) through specific inhibition of molecular targets, signal transducer and activator of transcription 3 (STAT3) and nuclear factor erythroid 2-related factor 2 (Nrf2) in HT-29 colon cancer cells. Cytotoxicity and apoptotic effects were investigated by methylthiazolyldiphenyl-​tetrazolium bromide assay and flow cytometry analysis, respectively. Real-time polymerase chain reaction was applied to assess the messenger RNA (mRNA) level of STAT3, Nrf2, and apoptotic genes including Bax, Bcl-xl, and Bcl-2. Read More

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http://dx.doi.org/10.1002/jcb.28678DOI Listing
April 2019
3.263 Impact Factor

Impact of bedaquiline and capreomycin on the gene expression patterns of multidrug-resistant Mycobacterium tuberculosis H37Rv strain and understanding the molecular mechanism of antibiotic resistance.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Bio-Sciences, Medical and Biological Computing Laboratory, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

The emergence of multidrug resistance (MDR), extensively drug-resistant, and total drug-resistant Mycobacterium tuberculosis (Mtb) strains have hampered the treatment of tuberculosis (TB). Capreomycin and Bedaquiline are currently used for MDR-TB treatment. To understand the impact of these antibiotics on Mtb genes, we have curated the gene expression data where the Mtb cultures were exposed to the Bedaquiline and Capreomycin. Read More

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http://dx.doi.org/10.1002/jcb.28711DOI Listing
April 2019
3.263 Impact Factor

Identification of association between rs1057317 polymorphism in TLR4 3'-untranslated region and the susceptibility to osteoporosis.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Orthopedics Department, Taizhou First People's Hospital, Taizhou, Zhejiang, China.

It has been proved that the expression of TLR4 is associated with a reduced risk of osteoporosis (OP). One single-nucleotide polymorphism located within the 3'-untranslated region (3'-UTR) of TLR4 may "generate" binding site of miR-34a and thereby associated with risk of OP. Bioinformatics analysis and luciferase reporter assay were used to specify the effect of polymorphisms on the interaction between miR-34a and TLR4 gene. Read More

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http://dx.doi.org/10.1002/jcb.28649DOI Listing
April 2019
2 Reads

Long noncoding RNA myocardial infarction associated transcript promotes the development of thoracic aortic by targeting microRNA-145 via the PI3K/Akt signaling pathway.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Vascular Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

The main aim of our study was to investigate the roles and molecular basis of long noncoding RNA myocardial infarction associated transcript (MIAT) in the development of thoracic aortic aneurysm. RT-qPCR assay was performed to measure the expressions of MIAT, microRNA-145 (miR-145), along with Bcl-2 and Bcl-xl messenger RNAs. Western blot assay was conducted to determine protein levels of Bcl-2, Bcl-xl, phosphorylated-Akt (p-Akt), and total Akt (t-Akt). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28695
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http://dx.doi.org/10.1002/jcb.28695DOI Listing
April 2019
2 Reads

BMP and mTOR signaling in heterotopic ossification: Does their crosstalk provide therapeutic opportunities?

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology and Department of Pathophysiology, School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi, China.

Heterotopic ossification (HO) refers to the pathological formation of ectopic bone in soft tissues, it occurs following severe trauma or in patients with a rare genetic disorder known as fibrodysplasia ossificans progressiva. The pathological process of HO formation is a two-step mechanism: inflammation and destruction of connective tissues, followed by bone formation. The latter is further subdivided into three stages: fibroproliferation/angiogenesis, chondrogenesis, and osteogenesis. Read More

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http://dx.doi.org/10.1002/jcb.28710DOI Listing
April 2019
3 Reads

microRNA-340-5p inhibits hypoxia/reoxygenation-induced apoptosis and oxidative stress in cardiomyocytes by regulating the Act1/NF-κB pathway.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiology, Gansu Provincial Hospital of TCM, Lanzhou, Gansu, China.

MicroRNAs (miRNAs) have been reported to play critical roles in the occurrence, progression, and treatment of many cardiovascular diseases. However, the molecular mechanism by which miRNA regulates target gene expression in ischemia-reperfusion (I/R) injury in acute myocardial infarction (AMI) is not entirely clear. MiR-340-5p was reported to be downregulated in acute ischemic stroke. Read More

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http://dx.doi.org/10.1002/jcb.28723DOI Listing
April 2019
1 Read

Human umbilical cord mesenchymal stem cells derived exosomes exert antiapoptosis effect via activating PI3K/Akt/mTOR pathway on H9C2 cells.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Cardiology, State Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Background/objectives: In recent years, as an alternative to stem cell therapy for cardiovascular diseases (CVD), exsomes have attracted wide attention among researchers. The present study aimed to investigate the role of human umbilical cord mesenchymal stem cells (UC-MSCs) derived exosomes play on H9C2 cells apoptosis and possible mechanisms.

Methods: Exosomes were isolated from normal UC-MSCs culture media and hypoxic preconditioning culture media. Read More

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http://dx.doi.org/10.1002/jcb.28705DOI Listing

Integrated analysis of a competing endogenous RNA network reveals key long noncoding RNAs as potential prognostic biomarkers for hepatocellular carcinoma.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Research Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China.

Growing evidence has revealed that long noncoding RNAs (lncRNAs) have an important impact on tumorigenesis and tumor progression via a mechanism involving competing endogenous RNAs (ceRNAs). However, their use in predicting the survival of a patient with hepatocellular carcinoma (HCC) remains unclear. The aim of this study was to develop a novel lncRNA expression-based risk score system to accurately predict the survival of patients with HCC. Read More

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http://dx.doi.org/10.1002/jcb.28655DOI Listing

microRNA-146a downregulates IL-17 and IL-35 and inhibits proliferation of human periodontal ligament stem cells.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthodontics and School of Dentistry, Chonbuk National University, Jeonju, South Korea.

Periodontitis is characterized by increased levels of proinflammatory factors, such as interleukin-17 (IL-17) and IL-35. In this study, the expression of microRNA-146a (miRNA-146a), IL-17, and IL-35 in the plasma of patients with periodontitis and healthy controls were detected by quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. miRNA-146a mimic was transfected into periodontal ligament stem cells (PDLSCs) isolated from periodontitis-affected teeth and healthy teeth. Read More

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http://dx.doi.org/10.1002/jcb.28659DOI Listing

Vinculin promotes gastric cancer proliferation and migration and predicts poor prognosis in patients with gastric cancer.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Gastroenterology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, Shandong, China.

Vinculin is a highly conserved protein involved in cell proliferation, migration, and adhesion. However, the effects of vinculin on gastric cancer (GC) remain unclear. Therefore, we aimed to explore the functional role of vinculin in GC, as well as its underlying mechanism. Read More

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http://dx.doi.org/10.1002/jcb.28686DOI Listing

Identification of blood microRNA alterations in patients with severe active alopecia areata.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Alopecia areata (AA) is a common inflammatory disease characterized by cellular infiltration of T cells targeting the anagen-stage hair follicle. Lack of efficacious treatment for AA may be due to little knowledge about its exact cellular mechanism. Studies have demonstrated that microRNAs (miRNAs) play an important role in the regulation of inflammatory skin diseases such as atopic dermatitis and psoriasis. Read More

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http://dx.doi.org/10.1002/jcb.28700DOI Listing
April 2019
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Inhibition of indoleamine 2,3-dioxygenase attenuates endotoxin-mediated tolerance in granulosa cells through kynurenine pathway.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Molecular Endocrinology, Functional Genomics, and Systems Biology Laboratory, Animal Biochemistry Division, National Dairy Research Institute, Karnal, Haryana, India.

Ovarian granulosa cells (GCs) have been shown to have innate immune capabilities, which modulate their native endocrine functions through toll-like receptors (TLRs). We have recently shown that GCs exposed to lipopolysaccharide (LPS; 1.0 µg/mL) transiently regulate proinflammatory cytokine expression (interleukin 1β [IL-1β], IL-6, and tumor necrosis factor α) through chromatin remodeling. Read More

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http://dx.doi.org/10.1002/jcb.28476DOI Listing

lncRNA-ATB promotes viability, migration, and angiogenesis in human microvascular endothelial cells by sponging microRNA-195.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Vascular Surgery, Jining No. 1 People's Hospital, Jining, China.

The atherosclerosis in the arterial system of the extremities is considered as the major pathogenesis of peripheral arterial disease. The present work aimed to explore the potential role of long noncoding RNA activated by tumor growth factor-β (lncRNA-ATB) on the dysfunction of endothelial cells. Human microvascular endothelial cells (HMEC-1) were transfected with lncRNA-ATB expressing vectors, and then the formation of tubes and expression of proteins associated with angiogenesis were analyzed using microscope and reverse transcription-quantitative polymerase chain reaction (RT-qPCR)/Western blot analysis. Read More

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http://dx.doi.org/10.1002/jcb.28692DOI Listing
April 2019
1 Read
3.263 Impact Factor

A new subset of small stem cells in bovine bone marrow stromal cell populations.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Laboratory for Stem Cell and Retinal Regeneration, Institute of Stem Cell Research, Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Bone marrow stromal cells (BMSCs) are a unique population of multipotent cells that exhibit pluripotent properties to a certain extent and are significantly heterogeneous in terms of the cell population. We isolate a small cell subpopulation from bovine BMSCs, bovine small stem cells (bSSCs), and herein characterize their properties. The bSSCs are smaller in size and express nuclear Oct-4 and other pluripotency markers. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28661
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http://dx.doi.org/10.1002/jcb.28661DOI Listing
April 2019
2 Reads

High expression of TCF12 contributes to gastric cancer development via being target regulated by miR-183 and activating PI3K/AKT pathway.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Breast and Thyroid Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

This study aimed to explore the role of transcription factor 12 (TCF12) in the process of gastric cancer (GC) and to elucidate its possible regulatory mechanism. The expression data of GC tissues and matched normal tissues were downloaded from The Cancer Genome Atlas (TCGA) database. Survival analysis for GC patients with different levels of TCF12 was performed by the Kaplan-Meier analysis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28664
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http://dx.doi.org/10.1002/jcb.28664DOI Listing
April 2019
2 Reads

Interleukin-1β/nuclear factor-κB signaling promotes osteosarcoma cell growth through the microRNA-181b/phosphatase and tensin homolog axis.

J Cell Biochem 2019 Feb 14;120(2):1763-1772. Epub 2018 Sep 14.

Department of Orthopedics, The Third Xiangya Hospital of Central South University, Changsha, China.

So far, microRNA has attracted plenty of interest due to its role in tumorigenesis. Reportedly, miR-181b may be involved in the tumorigenesis of osteosarcoma (OS). In the current study, we attempted to investigate the detailed function and mechanism of miR-181b in OS carcinogenesis. Read More

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http://dx.doi.org/10.1002/jcb.27477DOI Listing
February 2019

An immunosuppressive peptide from the horsefly inhibits inflammation by repressing macrophage maturation and phagocytosis.

J Cell Biochem 2019 Apr 11. Epub 2019 Apr 11.

Division of Cancer Immunity, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, Guangdong, China.

Ectoparasites repress host immune responses while they obtain nutrition from their hosts. Understanding the immunosuppressive mechanisms between ectoparasites and their hosts will provide new strategies to develop potential immunosuppressive drugs against immune disorder diseases. Previously, we have discovered that a small peptide, immunoregulin HA, from the horsefly (Hybomitra atriperoides) may play an immunosuppressive role in rat splenocytes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28687
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http://dx.doi.org/10.1002/jcb.28687DOI Listing
April 2019
3 Reads

Fibronectin promotes cervical cancer tumorigenesis through activating FAK signaling pathway.

J Cell Biochem 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Suzhou Traditional Chinese and Western Medicine Hospital, Suzhou, China.

Cervical cancer is a cancer arising from the cervix, and it is the fourth most common cause of death in women. Overexpression of fibronectin 1 (FN1) was observed in many tumors and associated with the survival and metastasis of cancer cells. However, the mechanism by which FN1 promotes cervical cancer cell viability, migration, adhesion, and invasion, and inhibits cell apoptosis through focal adhesion kinase (FAK) signaling pathway remains to be investigated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28282
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http://dx.doi.org/10.1002/jcb.28282DOI Listing
April 2019
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Three-dimensional electrospun gelatin scaffold coseeded with embryonic stem cells and sertoli cells: A promising substrate for in vitro coculture system.

J Cell Biochem 2019 Apr 11. Epub 2019 Apr 11.

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

In this study, we present an electrospun gelatin (EG) scaffold to mimic the extracellular matrix of the testis. The EG scaffold was synthesized by electrospinning and crosslinked with glutaraldehyde vapor to decrease its water solubility and degradation rate. The scanning electron microscope micrographs showed the homogenous morphology of randomly aligned gelatin fibers. Read More

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http://dx.doi.org/10.1002/jcb.28517DOI Listing
April 2019
3 Reads
3.263 Impact Factor

Atomic insight into prion disorder: An intricate detail gained by 0.5 μs molecular dynamics simulation of preventive G127V and deleterious D178V mutation in prion protein.

J Cell Biochem 2019 Apr 11. Epub 2019 Apr 11.

Department of Genetics, Islamic Azad University, Kāzerūn, Iran.

In this study we are looking into two contradicting mutations found in prion protein (PrP) viz G127V and D178V, that are reportedly protective and pathogenic, respectively. Despite significant advances in comprehension of the role of pathogenic mutations, the role of protective mutation in amyloid fold inhibition still lacks a substantial basis. To understand the structural basis of protective mutation, molecular dynamics simulation coupled with protein-protein docking and molecular mechanics/Poisson-Boltzmann surface area analysis was used to understand the instant structural variability brought about by these mutations alone and in combination on PrP and prion-prion complex. Read More

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http://dx.doi.org/10.1002/jcb.28690DOI Listing

The carboxy-terminus of the formin FMNL1ɣ bundles actin to potentiate adenocarcinoma migration.

J Cell Biochem 2019 Apr 11. Epub 2019 Apr 11.

Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, New York.

The formin family of proteins contributes to spatiotemporal control of actin cytoskeletal rearrangements during motile cell activities. The FMNL subfamily exhibits multiple mechanisms of linear actin filament formation and organization. Here we report novel actin-modifying functions of FMNL1 in breast adenocarcinoma migration models. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28694
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http://dx.doi.org/10.1002/jcb.28694DOI Listing
April 2019
1 Read