840 results match your criteria Journal of Cardiovascular Translational Research [Journal]


Correction to: Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design.

J Cardiovasc Transl Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

The authors of this study protocol would like to amend it and clarify that medication adherence was assessed using the 4-item validated Morisky, Green, Levine scale [Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-019-09870-9DOI Listing
February 2019

A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept.

J Cardiovasc Transl Res 2019 Feb 12. Epub 2019 Feb 12.

Cardiovascular Engineering Laboratory, UCL Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.

Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation in the GGTA-1 gene (GTKO) and fixed in 0. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-019-09868-3
Publisher Site
http://dx.doi.org/10.1007/s12265-019-09868-3DOI Listing
February 2019
3 Reads

Association of Genetic Polymorphisms in the Beta-1 Adrenergic Receptor with Recovery of Left Ventricular Ejection Fraction in Patients with Heart Failure.

J Cardiovasc Transl Res 2019 Feb 12. Epub 2019 Feb 12.

Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, USA.

Two common genetic polymorphisms in the beta-1 adrenergic receptor (ADRB1 Ser49Gly [rs1801252] and Arg389Gly [rs1801253]) significantly affect receptor function in vitro. The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure. Patients with heart failure and baseline LVEF ≤ 40% were genotyped (n = 98), and retrospective chart review assessed the primary outcome of LVEF recovery to ≥ 40%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-019-09866-5DOI Listing
February 2019

Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea.

J Cardiovasc Transl Res 2019 Jan 24. Epub 2019 Jan 24.

Cardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.

Dyspnea is a major symptom of heart failure (HF). Here, we have studied the lung remodeling and airway resistance in HF mice. We demonstrated that aortic banding-induced HF caused a dramatic decrease of lung compliance and an increase of lung airway resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-019-9864-yDOI Listing
January 2019

Beyond Reperfusion: Acute Ventricular Unloading and Cardioprotection During Myocardial Infarction.

J Cardiovasc Transl Res 2019 Jan 22. Epub 2019 Jan 22.

Huntington Medical Research Institutes, Pasadena, CA, USA.

Heart failure is a major cause of morbidity and mortality around the world, and myocardial infarction is its leading cause. Myocardial infarction destroys viable myocardium, and this dead tissue is replaced by a non-contractile scar that results in impaired cardiac function and a significantly increased likelihood of the patient developing heart failure. Limiting infarct scar size has been the target of pre-clinical and clinical investigations for decades. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-019-9863-zDOI Listing
January 2019

Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model.

J Cardiovasc Transl Res 2019 Jan 7. Epub 2019 Jan 7.

Department of Cardiology, Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an amiodarone group. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9861-6
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9861-6DOI Listing
January 2019
11 Reads

Exosomes in Cardiovascular Diseases and Treatment: Experimental and Clinical Aspects.

J Cardiovasc Transl Res 2019 Jan 7. Epub 2019 Jan 7.

Cardiac Regeneration and Ageing Laboratory, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, 200444, China.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9860-7
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9860-7DOI Listing
January 2019
5 Reads

Cardiac Progenitor Cell-Derived Extracellular Vesicles: a Rising Star for Cardiac Repair and Regeneration.

J Cardiovasc Transl Res 2019 Jan 4. Epub 2019 Jan 4.

Cardiac Regeneration and Ageing Laboratory, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9862-5
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9862-5DOI Listing
January 2019
3 Reads

Upregulation of Circulating Cardiomyocyte-Enriched miR-1 and miR-133 Associate with the Risk of Coronary Artery Disease in Type 2 Diabetes Patients and Serve as Potential Biomarkers.

J Cardiovasc Transl Res 2019 Jan 4. Epub 2019 Jan 4.

Department of Molecular Medicine/Al-Jawhara Centre for Molecular Medicine, Genetics and Inherited Disorders, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.

Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated their association with the risk of CAD risk and their potential as biomarkers. The two miRNAs were upregulated in patients with T2D and CAD compared with controls, associated with CAD risk and remained significant after adjustment for multiple confounders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9857-2DOI Listing
January 2019
1 Read

lncRNA HOTAIR Protects Myocardial Infarction Rat by Sponging miR-519d-3p.

J Cardiovasc Transl Res 2019 Jan 3. Epub 2019 Jan 3.

Department of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 West Huanghe Road in Huaiyin District, Huaian, 223300, Jiangsu, China.

Myocardial infarction (MI) is a cardiovascular disease with high morbidity and mortality. In this study, we focused on exploring the roles and underlying regulatory mechanisms of Hox transcript antisense intergenic RNA (HOTAIR) and miR-519d-3p in myocardial infarction. To comprehensively understand the role of microRNA in MI rat, we construct MI rat model by permanent ligation of the left anterior descending (LAD) coronary artery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9839-4DOI Listing
January 2019
1 Read

A Novel Wireless Left Atrial Pressure Monitoring System for Patients with Heart Failure, First Ex-Vivo and Animal Experience.

J Cardiovasc Transl Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Cardiology, Shaare Zedek Medical Center, Jerusalem, Israel.

The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9856-3DOI Listing
January 2019
1 Read

Amyloid Cardiomyopathy in the Rare Transthyretin Tyr78Phe Mutation.

J Cardiovasc Transl Res 2019 Jan 2. Epub 2019 Jan 2.

Cardiovascular Unit, Department of Internal Medicine, University of Genova and San Martino Hospital, Viale Benedetto XV, 6, 16132, Genoa, Italy.

Tyr78Phe is a rare pathogenic transthyretin (TTR) mutation. Few previous reports described a late-onset hereditary transthyretin-related amyloidosis (ATTR-m) form with a variable phenotype, mainly dominated by neurological manifestations. We describe the case of a 69-year-old male with massive but asymptomatic cardiac infiltration and only subclinical neurological involvement, and review the literature to depict characteristics of the Tyr78Phe TTR mutation. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9859-0
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9859-0DOI Listing
January 2019
8 Reads

Exercise Improves the Function of Endothelial Cells by MicroRNA.

J Cardiovasc Transl Res 2019 Jan 2. Epub 2019 Jan 2.

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, 200444, China.

Vascular diseases induced by diabetes and obesity (e.g., atherosclerosis) are associated with insulin resistance (IR), which leads to endothelial cell dysfunction due to metabolic disorder and oxidative stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9855-4DOI Listing
January 2019

Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model.

J Cardiovasc Transl Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Biomedical Engineering, Texas A&M University, Mailstop 3120, College Station, TX, 77843-3120, USA.

While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure model. High esmolol dose, targeting a 50% reduction in CO from healthy baseline, resulted in a failure state with mean CO 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9854-5DOI Listing
January 2019

MicroRNA-29b-3p Targets SPARC Gene to Protect Cardiocytes against Autophagy and Apoptosis in Hypoxic-Induced H9c2 Cells.

J Cardiovasc Transl Res 2018 Dec 17. Epub 2018 Dec 17.

Second Department of Cardiology, Xinxiang Central Hospital, Xinxiang, Henan, China.

MicroRNAs participate in the regulation of abnormal cardiomyocyte apoptosis and autophagy, which leads to heart failure (HF). Lower miR-29b-3p levels were found in HF patients in this study. However, the role of miR-29b-3p in the molecular pathogenesis of HF remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9858-1DOI Listing
December 2018

Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans.

J Cardiovasc Transl Res 2018 Dec 17. Epub 2018 Dec 17.

University of Oklahoma Health Sciences Center, 800 Stanton L Young Blvd Suite, Oklahoma City, OK, 5400, USA.

Low-level transcutaneous vagus nerve stimulation at the tragus (LLTS) is anti-adrenergic. We aimed to evaluate the acute effects of LLTS on left ventricular (LV) function and autonomic tone. Patients with diastolic dysfunction and preserved LV ejection fraction were enrolled in a prospective, randomized, double-blind, 2 × 2 cross-over study. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9853-6
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9853-6DOI Listing
December 2018
3 Reads

Release of Mitochondrial and Nuclear DNA During On-Pump Heart Surgery: Kinetics and Relation to Extracellular Vesicles.

J Cardiovasc Transl Res 2018 Dec 12. Epub 2018 Dec 12.

Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Science, University of Oslo, Postbox 1103, Blindern, 0317, Oslo, Norway.

During heart surgery with cardiopulmonary bypass (CPB), the release of mitochondrial (mtDNA) and nuclear DNA (nDNA) and their association to extracellular vesicles were investigated. In patients undergoing elective coronary artery bypass grafting (CABG, n = 12), blood was sampled before, during, and after surgery from peripheral artery, pulmonary artery, and the coronary sinus. Plasma was separated in three fractions: microvesicles, exosomes, and supernatant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9848-3DOI Listing
December 2018
1 Read

Identification and Functional Characterization of an ISL1 Mutation Predisposing to Dilated Cardiomyopathy.

J Cardiovasc Transl Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, Cardiovascular Research Laboratory, and Center for Complex Arrhythmias of Minhang District, The Fifth People's Hospital of Shanghai, Fudan University, No. 801 Heqing Road, Shanghai, 200240, China.

Dilated cardiomyopathy (DCM) is the most prevalent cause of non-ischemic cardiac failure and the commonest indication for cardiac transplantation. Compelling evidence highlights the pivotal roles of genetic defects in the occurrence of DCM. Nevertheless, the genetic determinants underpinning DCM remain largely obscure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9851-8DOI Listing
December 2018
1 Read

Advance for Cardiovascular Health in China.

J Cardiovasc Transl Res 2018 Dec 7. Epub 2018 Dec 7.

Institute of Cardiovascular Sciences, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.

As the most populous country worldwide, China has ≈ 290 million patients with cardiovascular diseases (CVDs), representing the leading cause of death in Chinese population. The morbidity and mortality of CVDs are continuously rising. Here, we will first summarize the recent advance in the management of CVDs such as coronary arterial disease, arrhythmia, and heart failure in China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9852-7DOI Listing
December 2018

Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design.

J Cardiovasc Transl Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

Improvements in ischemic heart disease (IHD) management have been unbalanced between sexes, with coronary microvascular dysfunction considered the likely underlying reason. The Endocrine Vascular disease Approach (EVA) is an observational study ( Clinicaltrial.gov NCT02737982) aiming to assess sex and gender interactions between coronary circulation, sexual hormones, and platelet function. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9846-5
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9846-5DOI Listing
December 2018
9 Reads

Serum Extracellular Vesicles Retard H9C2 Cell Senescence by Suppressing miR-34a Expression.

J Cardiovasc Transl Res 2018 Nov 29. Epub 2018 Nov 29.

Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, 389 Xin Cun Road, Shanghai, 200065, China.

Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced cardiomyocytes senescence remains elusive. In this study, we found that human serum EVs inhibited DOX-induced senescence in H9C2 cells, which was abolished by miR-34a mimic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9847-4DOI Listing
November 2018
1 Read

Comparative Quantification of Arterial Lipid by Intravascular Photoacoustic-Ultrasound Imaging and Near-Infrared Spectroscopy-Intravascular Ultrasound.

J Cardiovasc Transl Res 2018 Nov 28. Epub 2018 Nov 28.

Department of Cellular & Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, MS 385, Indianapolis, IN, 46202, USA.

Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo and ex vivo IVPA-US imaging of the iliac arteries of Ossabaw swine with metabolic syndrome (MetS) and lean swine to investigate sensitivity for early-stage atherosclerosis. We repeated imaging ex vivo with NIRS-IVUS for comparison to IVPA-US and histology. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9849-2
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9849-2DOI Listing
November 2018
7 Reads

Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output.

J Cardiovasc Transl Res 2018 Nov 19. Epub 2018 Nov 19.

Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University Hospital, SE-70185, Örebro, Sweden.

The impact of acute cardiac dysfunction on the gastrointestinal tract was investigated in anesthetized and instrumented pigs by sequential reductions of cardiac output (CO). Using a cardiac tamponade (n = 6) or partial inferior caval vein balloon inflation (n = 6), CO was controllably reduced for 1 h each to 75% (CO), 50% (CO), and 35% (CO) of the baseline value. Cardiac output in controls (n = 6) was not manipulated and maintained. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9845-6
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9845-6DOI Listing
November 2018
11 Reads

Cardiac Progenitor Cell-Derived Extracellular Vesicles Reduce Infarct Size and Associate with Increased Cardiovascular Cell Proliferation.

J Cardiovasc Transl Res 2018 Nov 19. Epub 2018 Nov 19.

Laboratory of Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands.

Cell transplantation studies have shown that injection of progenitor cells can improve cardiac function after myocardial infarction (MI). Transplantation of human cardiac progenitor cells (hCPCs) results in an increased ejection fraction, but survival and integration are low. Therefore, paracrine factors including extracellular vesicles (EVs) are likely to contribute to the beneficial effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9842-9DOI Listing
November 2018
12 Reads

Identification of Radiofrequency Ablation Catheter Parameters That May Induce Intracardiac Steam Pops: Direct Visualization of Elicitation in Reanimated Swine Hearts.

J Cardiovasc Transl Res 2018 Nov 14. Epub 2018 Nov 14.

Department of Surgery and the Institute for Engineering in Medicine, University of Minnesota, 420 Delaware St. SE, B172 Mayo, MMC 195, Minneapolis, MN, 55455, USA.

Radiofrequency, a common ablation modality, is used clinically to terminate cardiac arrhythmias. With excessive heating, complications sometimes occur when the applied energy generates steam pops, which cause release of energy in the form of tissue and/or air emboli. In this study, we investigated numerous parameters potentially associated with intracardiac steam pops including (1) wattage, (2) catheter tip temperature, (3) catheter irrigation, (4) anatomic site, and (5) repeat ablations at a given site. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9844-7
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9844-7DOI Listing
November 2018
10 Reads

Serum Uric Acid Is Independently Associated with Coronary Calcification in an Asymptomatic Population.

J Cardiovasc Transl Res 2018 Nov 9. Epub 2018 Nov 9.

Heart and Vascular Center, Semmelweis University, Városmajor Street 68, Budapest, H-1122, Hungary.

Detecting early-stage atherosclerosis is an important step towards cardiovascular disease prevention. Coronary artery calcium (CAC) score is a sensitive and non-invasive tool for detecting coronary atherosclerosis. Higher serum uric acid (SUA) levels are known to be associated with cardiovascular diseases. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9843-8
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9843-8DOI Listing
November 2018
6 Reads

Immunomodulation by Exosomes in Myocardial Infarction.

J Cardiovasc Transl Res 2018 Oct 29. Epub 2018 Oct 29.

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.

Exosomes are important carriers of biological information that facilitate intercellular communication and participate in the pathophysiology of different cardiovascular diseases. Myocardial infarction is among the leading causes of death worldwide. Upon myocardial infarction, massive cardiomyocyte death triggers a strong inflammatory response which is a vital process of cardiac injury, repair, and remodeling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9836-7DOI Listing
October 2018

Bioresorbable Scaffold-Based Controlled Drug Delivery for Restenosis.

J Cardiovasc Transl Res 2018 Oct 26. Epub 2018 Oct 26.

Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Ave., Bldg 22, Rm 4176, Silver Spring, MD, 20993, USA.

Bioresorbable scaffolds have emerged as a potential alternative to non-erodible metal implants to alleviate the long-term risk of permanent device vascular implant-related adverse events. Bioresorbable scaffolds provide a temporary mechanical support function until the vessel reaches complete healing, and the implant progressively disappears and vasomotion resumes. A polymer matrix with embedded drugs coated onto the scaffold surface degrades slowly, reducing the size from the exterior toward the interior, and this allows controlled drug release to a local vascular segment. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9841-x
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9841-xDOI Listing
October 2018
11 Reads

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury.

J Cardiovasc Transl Res 2018 Dec 26;11(6):503-516. Epub 2018 Oct 26.

Department of Cardiothoracic Surgery and Anesthesia, Uppsala University Hospital, SE-751 85, Uppsala, Sweden.

Surgery on the arch or descending aorta is associated with significant risk of neurological complications. As a consequence of intubation and sedation, early neurologic injury may remain unnoticed. Biomarkers to aid in the initial diagnostics could prove of great value as immediate intervention is critical. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9835-8
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9835-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294830PMC
December 2018
11 Reads

Long-Term Weight Gain Associated With High Omentin Levels at Hospital Discharge Improves Prognosis of Patients Following Acute Heart Failure.

J Cardiovasc Transl Res 2018 Oct 23. Epub 2018 Oct 23.

Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.

A obesity paradox has been described following heart failure (HF). The aim of this study was to analyze the association between food intake-involved adipokines and long-term weight changes. Leptin, adiponectin, and omentin were analyzed in 92 acute HF (AHF) patients at discharge, classified on the basis of weight gains or losses > 6%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9840-yDOI Listing
October 2018
3 Reads

Stem Cell Homing: a Potential Therapeutic Strategy Unproven for Treatment of Myocardial Injury.

J Cardiovasc Transl Res 2018 10 15;11(5):403-411. Epub 2018 Oct 15.

Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, Jiangsu, People's Republic of China.

Despite advances in the prevention and therapeutic modalities of ischemic heart disease, morbidity and mortality post-infarction heart failure remain big challenges in modern society. Stem cell therapy is emerging as a promising therapeutic strategy. Stem cell homing, the ability of stem cells to find their destination, is receiving more attention. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9823-z
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9823-zDOI Listing
October 2018
7 Reads

Does No-Touch Technique Better than Conventional or Intermediate Saphenous Vein Harvest Techniques for Coronary Artery Bypass Graft Surgery: a Systematic Review and Meta-analysis.

J Cardiovasc Transl Res 2018 Dec 12;11(6):483-494. Epub 2018 Oct 12.

Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Saphenous vein (SV) is a common graft being used in coronary artery bypass grafting (CABG). Conventional (CON), intermediate (I), and no-touch (NT) are the most common harvesting techniques of SV for CABG. The aim of this study is to systematically review the NT versus CON and I techniques in harvesting SV for CABG. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9832-y
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9832-yDOI Listing
December 2018
3 Reads

A Simple Modified Framingham Scoring System to Predict Obstructive Coronary Artery Disease.

J Cardiovasc Transl Res 2018 Dec 12;11(6):495-502. Epub 2018 Oct 12.

Department of Cardiology, Provincial Key Laboratory of Coronary Heart Disease, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China.

Development of simple non-invasive risk prediction model would help in early prediction of coronary artery disease (CAD) reducing the burden on public health. This paper demonstrates a risk prediction scoring system to predict obstructive coronary artery disease (OCAD) in CAD patients. A total of 13,082 patients, referred for coronary angiography (CAG) in TRUST trial, were included in the development of a multivariable diagnostic prediction model. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9837-6
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9837-6DOI Listing
December 2018
2 Reads

Interleukin-1 Receptor-Like 1 (IL1R1) Levels Are Not Increased in Healthy Centenarians.

J Cardiovasc Transl Res 2018 Oct 9. Epub 2018 Oct 9.

Servicio de Cardiología, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón. CIBERCV, Calle Doctor Esquerdo, 46, 28007, Madrid, Spain.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9838-5
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9838-5DOI Listing
October 2018
2 Reads

Effect of Long-Term Exercise Training on lncRNAs Expression in the Vascular Injury of Insulin Resistance.

J Cardiovasc Transl Res 2018 Dec 9;11(6):459-469. Epub 2018 Oct 9.

Cardiac Rehabilitation Center of Rehabilitation Department, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan, People's Republic of China.

LncRNA microarray analysis was applied to investigate the exercise effect on the global differential expressions of lncRNA and mRNA in aorta endothelium in insulin resistance. Twenty-four male C57BL/6 J mice were randomly divided into three groups: control group (n = 8), high-fat diet group (n = 8), and high-fat diet plus exercise training group (n = 8). An lncRNA microarray analysis was applied to investigate the global differential expressions of lncRNA and mRNA in aorta endothelium among three groups and the results were further verified by qPCR. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9830-0
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9830-0DOI Listing
December 2018
1 Read

Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention.

J Cardiovasc Transl Res 2018 Dec 1;11(6):517-523. Epub 2018 Oct 1.

Department of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.

The prognostic role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with stable coronary artery disease (CAD) is still unclear. We enrolled 500 patients undergoing elective percutaneous coronary intervention (PCI). Blood samples were drawn prior to PCI for NLR and PLR calculation. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9829-6
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9829-6DOI Listing
December 2018
2 Reads

Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes for Angiogenesis.

J Cardiovasc Transl Res 2018 10 1;11(5):429-437. Epub 2018 Oct 1.

Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.

We demonstrated the effects of exosomes secreted by cardiac mesenchymal stem cells (C-MSC-Exo) in protecting acute ischemic myocardium from reperfusion injury. To investigate the effect of exosomes from C-MSC on angiogenesis, we injected C-MSC-Exo or PBS intramuscularly into ischemic hind limb. Blood perfusion of limb was evaluated by laser Doppler Imaging. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9824-y
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9824-yDOI Listing
October 2018
13 Reads

Concept, Evaluation, and Future Perspectives of PERKAT® RV-A Novel Right Ventricular Assist Device.

J Cardiovasc Transl Res 2018 Sep 28. Epub 2018 Sep 28.

HSK, Department of Internal Medicine I, Helios-Clinics, Wiesbaden, Germany.

Right heart failure (RHF) is a life-threatening condition. Mechanical right heart support offers an option for critically ill patients. The PERKAT® RV device is designed for percutaneous implantation in acute RHF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9834-9DOI Listing
September 2018
9 Reads

The Use of Serum MMP-9 and TIMP-1 in Acute Coronary Syndrome.

J Cardiovasc Transl Res 2018 Dec 24;11(6):526-527. Epub 2018 Sep 24.

Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki 1, Haartmaninkatu 8, 00290, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9833-xDOI Listing
December 2018
6 Reads

The Exosome: a New Player in Diabetic Cardiomyopathy.

J Cardiovasc Transl Res 2018 Sep 24. Epub 2018 Sep 24.

Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou City, 213003, China.

Diabetic cardiomyopathy (DCM) or diabetes-induced cardiac dysfunction is a direct consequence of uncontrolled metabolic syndrome and occurs worldwide. However, the underlying cellular and molecular mechanisms remain poorly understood. Recently, exosomes have attracted considerable interest for their use as efficient, targeted, and non-immunogenic delivery systems for biological molecules or pharmacotherapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9825-xDOI Listing
September 2018
1 Read

Aerobic Exercise Prevents Insulin Resistance Through the Regulation of miR-492/Resistin Axis in Aortic Endothelium.

J Cardiovasc Transl Res 2018 Dec 19;11(6):450-458. Epub 2018 Sep 19.

Department of Rehabilitation, Cardiac Rehabilitation Center, Xiangya Hospital, Central South University, Xiang-Ya Road 87, 410008, Changsha, Hunan Province, People's Republic of China.

Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we investigated the effects of the miR-492/resistin axis on improving endothelial injury in ApoE-/- mice (ApoE-deficient/knockout in C57BL/6 mice) through swimming exercises. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9828-7DOI Listing
December 2018

Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes Promotes Repair in Ischemic Myocardium.

J Cardiovasc Transl Res 2018 10 19;11(5):420-428. Epub 2018 Sep 19.

Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.

Our previous study demonstrated the beneficial effects of exosomes secreted by cardiac mesenchymal stem cells (C-MSC-Exo) in protecting acute ischemic myocardium from reperfusion injury. Here, we investigated the effect of exosomes from C-MSC on angiogenesis in ischemic myocardium. We intramyocardially injected C-MSC-Exo or PBS into the infarct border zone after induction of acute mouse myocardial infarction (MI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9822-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212335PMC
October 2018
5 Reads

New Insights into the Role of Exosomes in the Heart After Myocardial Infarction.

J Cardiovasc Transl Res 2018 Sep 2. Epub 2018 Sep 2.

Unité de Physiopathologie Clinique, Département cœur-vaisseaux, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Bugnon 7a, 1005, Lausanne, Switzerland.

Intercellular communications play a pivotal role in several cardiac pathophysiological processes. One subtype of extracellular vesicles, so-called exosomes, became known as important intercellular communication mediators in the heart. Exosomes are lipid bilayer biological nanovesicles loaded with diverse proteins, lipids, and mRNAs/microRNAs. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12265-018-9831-z
Publisher Site
http://dx.doi.org/10.1007/s12265-018-9831-zDOI Listing
September 2018
4 Reads

Noncoding RNAs in Cardiac Hypertrophy.

J Cardiovasc Transl Res 2018 Dec 31;11(6):439-449. Epub 2018 Aug 31.

Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.

Cardiac hypertrophy is classified as pathological and physiological hypertrophy. Pathological hypertrophy typically precedes the onset of heart failure, one of the largest contributors to disease burden and deaths worldwide. In contrast, physiological hypertrophy is an adaptive response and protects against adverse cardiac remodeling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9797-xDOI Listing
December 2018
14 Reads

Exosome-Derived Dystrophin from Allograft Myogenic Progenitors Improves Cardiac Function in Duchenne Muscular Dystrophic Mice.

J Cardiovasc Transl Res 2018 10 28;11(5):412-419. Epub 2018 Aug 28.

Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.

Progressive cardiomyocyte loss in Duchenne muscular dystrophy (DMD) leads to cardiac fibrosis, cardiomyopathy, and eventually heart failure. In the present study, we observed that myogenic progenitor cells (MPC) carry mRNA for the dystrophin gene. We tested whether cardiac function can be improved in DMD by allograft transplantation of MPC-derived exosomes (MPC-Exo) into the heart to restore dystrophin protein expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9826-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212302PMC
October 2018
21 Reads

Serum or Plasma Matrix Metalloproteinase (MMP)-9 Levels and Cardiovascular Diseases.

J Cardiovasc Transl Res 2018 Dec 21;11(6):524-525. Epub 2018 Aug 21.

Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9827-8DOI Listing
December 2018

Development of a Novel Human Cell-Derived Tissue-Engineered Heart Valve for Transcatheter Aortic Valve Replacement: an In Vitro and In Vivo Feasibility Study.

J Cardiovasc Transl Res 2018 Dec 13;11(6):470-482. Epub 2018 Aug 13.

Institute for Regenerative Medicine (IREM), University of Zurich, Center for Therapy Development/GMP, Zurich, Switzerland.

Transcatheter aortic valve replacement (TAVR) is being extended to younger patients. However, TAVR-compatible bioprostheses are based on xenogeneic materials with limited durability. Off-the-shelf tissue-engineered heart valves (TEHVs) with remodeling capacity may overcome the shortcomings of current TAVR devices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9821-1DOI Listing
December 2018

Mechanical Unloading by Fulminant Myocarditis: LV-IMPELLA, ECMELLA, BI-PELLA, and PROPELLA Concepts.

J Cardiovasc Transl Res 2018 Aug 6. Epub 2018 Aug 6.

Charité, University Medicine Berlin, Department of Cardiology, Campus Virchow Klinikum, Berlin, Germany.

Mechanical circulatory support (MCS) is often required to stabilize patients with acute fulminant myocarditis with cardiogenic shock. This review gives an overview of the successful use of left-sided Impella in the setting of fulminant myocarditis and cardiogenic shock as the sole means of MCS as well as in combination with right ventricular (RV) support devices including extracorporeal life support (ECLS) (ECMELLA) or an Impella RP (BI-PELLA). It further provides evidence from endomyocardial biopsies that in addition to giving adequate support, LV unloading by Impella exhibits disease-modifying effects important for myocardial recovery (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9820-2DOI Listing
August 2018
4 Reads

Mirabegron, a Clinically Approved β3 Adrenergic Receptor Agonist, Does Not Reduce Infarct Size in a Swine Model of Reperfused Myocardial Infarction.

J Cardiovasc Transl Res 2018 08 2;11(4):310-318. Epub 2018 Aug 2.

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.

The administration of the selective β3 adrenergic receptor (β3AR) agonist BRL-37344 protects from myocardial ischemia/reperfusion injury (IRI), although the lack of clinical approval limits its translatability. We tested the cardioprotective effect of mirabegron, the first-in-class β3AR agonist approved for human use. A dose-response study was conducted in 6 pigs to select the highest intravenous dose of mirabegron without significant detrimental hemodynamic effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9819-8DOI Listing
August 2018
4 Reads

Study of Serum CD147 Level in Patients with Transient Ischemic Attack and CD147 Expression in Atherosclerotic Plaque.

J Cardiovasc Transl Res 2018 08 23;11(4):285-291. Epub 2018 Jul 23.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, 100050, China.

There is growing evidence that highlighted the potential effects of CD147 in atherosclerosis, but the potential implication of CD147 in diagnosis and treatment of transient ischemic attack (TIA) and acute cerebral infarction (ACI) is still unclear. In this work, we investigated the serum level of CD147 in patients with TIA and ACI, and CD147 expression in atherosclerotic plaque. The result showed significantly increasing serum level of CD147 in patients with TIA and ACI, and increasing amount of CD147 in vulnerable plaque compared with that in migrating plaque. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12265-018-9817-xDOI Listing
August 2018
4 Reads