856 results match your criteria Journal of Cardiovascular Translational Research [Journal]


Plasma Complement Protein C3a Level Was Associated with Abdominal Aortic Calcification in Patients on Hemodialysis.

J Cardiovasc Transl Res 2019 Apr 15. Epub 2019 Apr 15.

Renal Division, Department of internal Medicine, Peking University First Hospital, Beijing, 100034, China.

The complement system plays an important role in cardiovascular disease in patients on hemodialysis. Vascular calcification is also one of the major causes of cardiovascular disease. We want to investigate the relationship between complement activation and vascular calcification in dialyzed patients. Read More

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http://dx.doi.org/10.1007/s12265-019-09885-2DOI Listing

Protection of Myocardial Ischemia-Reperfusion by Therapeutic Hypercapnia: a Mechanism Involving Improvements in Mitochondrial Biogenesis and Function.

J Cardiovasc Transl Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Anesthesiology, The Heilongjiang Province Key Lab of Research on Anesthesiology and Critical Care Medicine, Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Previous studies proposed that acidic reperfusion may be a protective strategy for myocardial ischemia-reperfusion therapy with potential of clinical transformation. In this study, we investigated whether therapeutic hypercapnia could mimic acidosis postconditioning in isolated hearts with a 30-min left coronary artery ligation-reperfusion model in rats. Therapeutic hypercapnia (inhalation 20% CO for 10 min) is cardioprotective with a strict therapeutic time window and acidity: it reduced the infarct ratio and serum myocardial enzyme and increased the myocardial ATP content. Read More

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http://dx.doi.org/10.1007/s12265-019-09886-1DOI Listing
April 2019
1 Read

TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion.

J Cardiovasc Transl Res 2019 Apr 8. Epub 2019 Apr 8.

Department of Anaesthesiology, Intensive Care Medicine, and Pain Therapy, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

We have shown previously that during myocardial ischemia/reperfusion (MI/R), toll-like receptor 2 (TLR2) signaling regulates connexin 43 (Cx43) subcellular localization and function and dampens arrhythmia formation. We aimed to identify sites capable of TLR2-dependent redox modification within Cx43. Post-ischemic TLR2 or wild-type (WT) mouse hearts were analyzed by OxICAT. Read More

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http://dx.doi.org/10.1007/s12265-019-09887-0DOI Listing

New Mechanistic Insight and Approaches for the Field of Acute Mechanical Circulatory Support.

Authors:
Navin K Kapur

J Cardiovasc Transl Res 2019 Apr 8. Epub 2019 Apr 8.

The Cardiovascular Center for Research and Innovation, The Molecular Cardiology Research Institute, and the Surgical and Interventional Research Laboratories, Tufts Medical Center, 800 Washington Street, Box # 80, Boston, MA, 02111, USA.

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http://dx.doi.org/10.1007/s12265-019-09884-3DOI Listing

A Promising Treatment of Distal Entry Tears Located in Branched Area of Abdominal Aorta With Coil-Stent Tear Occlusion Device: an Animal Experiment.

J Cardiovasc Transl Res 2019 Mar 26. Epub 2019 Mar 26.

Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.

This study aims to evaluate the effect of coil-stent tear occlusion device in treating entry tears located in branched area of abdominal aorta. An abdominal aortic dissection animal model was constructed by mesh suturing method. The animal models were treated by the occlusion device and were evaluated by computed tomography angiography (CTA) 1 month later. Read More

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http://dx.doi.org/10.1007/s12265-019-09869-2DOI Listing
March 2019
1 Read

Long Noncoding RNA-CERNA1 Stabilized Atherosclerotic Plaques in apolipoprotein E Mice.

J Cardiovasc Transl Res 2019 Mar 19. Epub 2019 Mar 19.

Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, People's Republic of China.

Atherosclerosis is predicted to be the primary cause of death in the world by 2020. Changes in atherosclerotic plaque composition will lead to acute coronary syndromes. Although the studies on the molecular mechanisms of long noncoding RNA (lncRNA) are in-depth in molecular and cell levels, the in vivo research which studied the knowledge about lncRNAs in the regulation of plaque composition is still sparse. Read More

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http://dx.doi.org/10.1007/s12265-019-09883-4DOI Listing
March 2019
1 Read

Kdm6A Protects Against Hypoxia-Induced Cardiomyocyte Apoptosis via H3K27me3 Demethylation of Ncx Gene.

J Cardiovasc Transl Res 2019 Mar 18. Epub 2019 Mar 18.

Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.

Molecular events involved in acute myocardial infarction (AMI) still remain unclear. A rat AMI model and cardiomyocytes cultured in vitro were used to mimic hypoxic conditions, and the profiles of histone methylation-related gene expression were explored. The demethylase Kdm6a expression was significantly upregulated in the rat AMI model and in hypoxia induction. Read More

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http://dx.doi.org/10.1007/s12265-019-09882-5DOI Listing

Intra-aortic Balloon Counterpulsation for High-Risk Percutaneous Coronary Intervention: Defining Coronary Responders.

J Cardiovasc Transl Res 2019 Mar 15. Epub 2019 Mar 15.

School of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Excellence and National Institute for Health Research Biomedical Research Centre, St. Thomas' Hospital Campus, King's College London, London, SE1 7EH, UK.

The effect of intra-aortic balloon counterpulsation (IABC) varies, and it is unknown whether this is due to a heterogeneous coronary physiological response. This study aimed to characterise the coronary and left ventricular (LV) effects of IABC and define responders in terms of their invasive physiology. Twenty-seven patients (LVEF 31 ± 9%) underwent coronary pressure and Doppler flow measurements in the target vessel and acquisition of LV pressure volume loops after IABC supported PCI, with and without IABC assistance. Read More

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http://dx.doi.org/10.1007/s12265-019-09871-8DOI Listing

Ex Vivo Pilot Study of Cardiac Magnetic Resonance Velocity Mapping for Quantification of Aortic Regurgitation in a Porcine Model in the Presence of a Transcatheter Heart Valve.

J Cardiovasc Transl Res 2019 Mar 15. Epub 2019 Mar 15.

Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Accuracy of aortic regurgitation (AR) quantification by magnetic resonance (MR) imaging in the presence of a transcatheter heart valve (THV) remains to be established. We evaluated the accuracy of cardiac MR velocity mapping for quantification of antegrade flow (AF) and retrograde flow (RF) across a THV and the optimal slice position to use in cardiac MR imaging. In a systematic and fully controlled laboratory ex vivo setting, two THVs (Edwards SAPIEN XT, Medtronic CoreValve) were tested in a porcine model (n = 1) under steady flow conditions. Read More

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http://dx.doi.org/10.1007/s12265-019-09878-1DOI Listing
March 2019
1 Read
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Right Ventricular Function After Pulmonary Artery Banding: Adaptive Processes Assessed by CMR and Conductance Catheter Measurements in Sheep.

J Cardiovasc Transl Res 2019 Mar 7. Epub 2019 Mar 7.

Department of Cardiac Surgery, University Clinic, Schillingallee 35, 10857, Rostock, Germany.

This experimental study describes the adaptive processes of the right ventricular (RV) myocardium after pulmonary artery banding (PAB) evaluated by cine cardiac magnetic resonance (CMR), phase-contrast CMR (PC-CMR), and conductance catheter. Seven sheep were subjected to CMR 3 months after PAB. Conductance catheter measurements were performed before and 3 months after PAB. Read More

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http://dx.doi.org/10.1007/s12265-019-09881-6DOI Listing
March 2019
1 Read

Identification of miR-143 as a Major Contributor for Human Stenotic Aortic Valve Disease.

J Cardiovasc Transl Res 2019 Mar 6. Epub 2019 Mar 6.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Calcification of aortic valves leads to aortic stenosis mainly in elderly individuals, but the underlying molecular mechanisms are still not understood. Here, we studied microRNA (miR, miRNA) expression and function in healthy and stenotic human aortic valves. We identified miR-21, miR-24, and miR-143 to be highly upregulated in stenotic aortic valves. Read More

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http://dx.doi.org/10.1007/s12265-019-09880-7DOI Listing
March 2019
2 Reads

Adipokine Dysregulation and Insulin Resistance with Atherosclerotic Vascular Disease: Metabolic Syndrome or Independent Sequelae?

J Cardiovasc Transl Res 2019 Mar 5. Epub 2019 Mar 5.

Department of Clinical & Translational Science, The Peekie Nash Carpenter Endowed Chair in Medicine, Creighton University School of Medicine, CRISS II Room 510, 2500 California Plaza, Omaha, NE, 68178, USA.

Adipokine dysregulation and insulin resistance are two hallmark sequelae attributed to the current clinical definition of metabolic syndrome (MetS) that are also linked to atherosclerotic vascular disease. Here, we critically discuss the underlying pathophysiological mechanisms and the interplay between the two sequelae. Adipokine dysregulation is involved with decreased nitric oxide, vascular inflammation, and insulin resistance in itself to promote atherosclerosis. Read More

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http://link.springer.com/10.1007/s12265-019-09879-0
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http://dx.doi.org/10.1007/s12265-019-09879-0DOI Listing
March 2019
7 Reads

Changes in Titin and Collagen Modulate Effects of Aerobic and Resistance Exercise on Diabetic Cardiac Function.

J Cardiovasc Transl Res 2019 Feb 28. Epub 2019 Feb 28.

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Diastolic dysfunction is a common complication that occurs early in diabetes mellitus. Titin and collagen are two important regulators of myocardial passive tension, which contributes to diabetic myocardial diastolic dysfunction. Exercise therapy significantly improves the impaired diabetic cardiac function, but its benefits appear to depend on the type of exercise used. Read More

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http://dx.doi.org/10.1007/s12265-019-09875-4DOI Listing
February 2019
2 Reads

Loss of Regulatory Immune Function in Coronary Artery Disease Patients from the Indian Population.

J Cardiovasc Transl Res 2019 Feb 27. Epub 2019 Feb 27.

Molecular Immunology Unit, Thrombosis Research Institute, Bangalore, India.

The pathogenic roles of inflammatory T cells and monocytes subsets have not been explored in different manifestations of coronary artery disease. We studied the frequency of these cells, their response to autoantigens, regulatory cell functional assay, foam cell formation and macrophage differentiation in 181 patients (stable angina, ST-elevated myocardial infarction (STEMI), NSTEMI, and unstable angina), and 34 controls and in samples collected during recurrent cardiac events and from patients showing clinical improvement. The proportion of Th17 cells and monocytes gradually increased in patients with stable angina at one end of the spectrum followed by NSTEMI, STEMI, and unstable angina at other end. Read More

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http://dx.doi.org/10.1007/s12265-019-09872-7DOI Listing
February 2019
2 Reads

Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with MYL2-R58Q-Mediated Apical Hypertrophic Cardiomyopathy Show Hypertrophy, Myofibrillar Disarray, and Calcium Perturbations.

J Cardiovasc Transl Res 2019 Feb 22. Epub 2019 Feb 22.

Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN, 55905, USA.

Hypertrophic cardiomyopathy (HCM), characterized by unexplained left ventricular hypertrophy, is one of the most common heritable cardiovascular diseases. The myosin regulatory light chain (MYL2) mutation R58Q has been associated with severe cardiac hypertrophy and sudden cardiac death (SCD). Herein, we provide the first patient-specific, induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of MYL2-R58Q. Read More

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http://dx.doi.org/10.1007/s12265-019-09873-6DOI Listing
February 2019
1 Read

KC21 Peptide Inhibits Angiogenesis and Attenuates Hypoxia-Induced Retinopathy.

J Cardiovasc Transl Res 2019 Feb 21. Epub 2019 Feb 21.

Departments of Medical Research, Mackay Memorial Hospital, Taipei, 10449, Taiwan.

Desmogleins (Dsg2) are the major components of desmosomes. Dsg2 has five extracellular tandem cadherin domains (EC1-EC5) for cell-cell interaction. We had previously confirmed the Dsg2 antibody and its epitope (named KC21) derived from EC2 domain suppressing epithelial-mesenchymal transition and invasion in human cancer cell lines. Read More

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http://dx.doi.org/10.1007/s12265-019-09865-6DOI Listing
February 2019
1 Read

Correction to: Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design.

J Cardiovasc Transl Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

The authors of this study protocol would like to amend it and clarify that medication adherence was assessed using the 4-item validated Morisky, Green, Levine scale [Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. Read More

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http://dx.doi.org/10.1007/s12265-019-09870-9DOI Listing
February 2019

A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept.

J Cardiovasc Transl Res 2019 Feb 12. Epub 2019 Feb 12.

Cardiovascular Engineering Laboratory, UCL Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.

Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation in the GGTA-1 gene (GTKO) and fixed in 0. Read More

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http://link.springer.com/10.1007/s12265-019-09868-3
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http://dx.doi.org/10.1007/s12265-019-09868-3DOI Listing
February 2019
3 Reads

Association of Genetic Polymorphisms in the Beta-1 Adrenergic Receptor with Recovery of Left Ventricular Ejection Fraction in Patients with Heart Failure.

J Cardiovasc Transl Res 2019 Feb 12. Epub 2019 Feb 12.

Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, USA.

Two common genetic polymorphisms in the beta-1 adrenergic receptor (ADRB1 Ser49Gly [rs1801252] and Arg389Gly [rs1801253]) significantly affect receptor function in vitro. The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure. Patients with heart failure and baseline LVEF ≤ 40% were genotyped (n = 98), and retrospective chart review assessed the primary outcome of LVEF recovery to ≥ 40%. Read More

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http://dx.doi.org/10.1007/s12265-019-09866-5DOI Listing
February 2019

Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea.

J Cardiovasc Transl Res 2019 Jan 24. Epub 2019 Jan 24.

Cardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.

Dyspnea is a major symptom of heart failure (HF). Here, we have studied the lung remodeling and airway resistance in HF mice. We demonstrated that aortic banding-induced HF caused a dramatic decrease of lung compliance and an increase of lung airway resistance. Read More

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http://dx.doi.org/10.1007/s12265-019-9864-yDOI Listing
January 2019
3 Reads

Beyond Reperfusion: Acute Ventricular Unloading and Cardioprotection During Myocardial Infarction.

J Cardiovasc Transl Res 2019 Jan 22. Epub 2019 Jan 22.

Huntington Medical Research Institutes, Pasadena, CA, USA.

Heart failure is a major cause of morbidity and mortality around the world, and myocardial infarction is its leading cause. Myocardial infarction destroys viable myocardium, and this dead tissue is replaced by a non-contractile scar that results in impaired cardiac function and a significantly increased likelihood of the patient developing heart failure. Limiting infarct scar size has been the target of pre-clinical and clinical investigations for decades. Read More

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http://dx.doi.org/10.1007/s12265-019-9863-zDOI Listing
January 2019
8 Reads

Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model.

J Cardiovasc Transl Res 2019 Jan 7. Epub 2019 Jan 7.

Department of Cardiology, Heart Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an amiodarone group. Read More

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http://link.springer.com/10.1007/s12265-018-9861-6
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http://dx.doi.org/10.1007/s12265-018-9861-6DOI Listing
January 2019
21 Reads

Exosomes in Cardiovascular Diseases and Treatment: Experimental and Clinical Aspects.

J Cardiovasc Transl Res 2019 Feb 7;12(1):1-2. Epub 2019 Jan 7.

Cardiac Regeneration and Ageing Laboratory, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, 200444, China.

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http://link.springer.com/10.1007/s12265-018-9860-7
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http://dx.doi.org/10.1007/s12265-018-9860-7DOI Listing
February 2019
11 Reads

Cardiac Progenitor Cell-Derived Extracellular Vesicles: a Rising Star for Cardiac Repair and Regeneration.

J Cardiovasc Transl Res 2019 Feb 4;12(1):3-4. Epub 2019 Jan 4.

Cardiac Regeneration and Ageing Laboratory, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.

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http://link.springer.com/10.1007/s12265-018-9862-5
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http://dx.doi.org/10.1007/s12265-018-9862-5DOI Listing
February 2019
9 Reads

Upregulation of Circulating Cardiomyocyte-Enriched miR-1 and miR-133 Associate with the Risk of Coronary Artery Disease in Type 2 Diabetes Patients and Serve as Potential Biomarkers.

J Cardiovasc Transl Res 2019 Jan 4. Epub 2019 Jan 4.

Department of Molecular Medicine/Al-Jawhara Centre for Molecular Medicine, Genetics and Inherited Disorders, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.

Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without and with coronary artery disease (CAD) and healthy controls, investigated their association with the risk of CAD risk and their potential as biomarkers. The two miRNAs were upregulated in patients with T2D and CAD compared with controls, associated with CAD risk and remained significant after adjustment for multiple confounders. Read More

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http://dx.doi.org/10.1007/s12265-018-9857-2DOI Listing
January 2019
2 Reads

lncRNA HOTAIR Protects Myocardial Infarction Rat by Sponging miR-519d-3p.

J Cardiovasc Transl Res 2019 Jan 3. Epub 2019 Jan 3.

Department of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 West Huanghe Road in Huaiyin District, Huaian, 223300, Jiangsu, China.

Myocardial infarction (MI) is a cardiovascular disease with high morbidity and mortality. In this study, we focused on exploring the roles and underlying regulatory mechanisms of Hox transcript antisense intergenic RNA (HOTAIR) and miR-519d-3p in myocardial infarction. To comprehensively understand the role of microRNA in MI rat, we construct MI rat model by permanent ligation of the left anterior descending (LAD) coronary artery. Read More

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http://dx.doi.org/10.1007/s12265-018-9839-4DOI Listing
January 2019
3 Reads

A Novel Wireless Left Atrial Pressure Monitoring System for Patients with Heart Failure, First Ex-Vivo and Animal Experience.

J Cardiovasc Transl Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Cardiology, Shaare Zedek Medical Center, Jerusalem, Israel.

The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. Read More

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http://dx.doi.org/10.1007/s12265-018-9856-3DOI Listing
January 2019
2 Reads

Amyloid Cardiomyopathy in the Rare Transthyretin Tyr78Phe Mutation.

J Cardiovasc Transl Res 2019 Jan 2. Epub 2019 Jan 2.

Cardiovascular Unit, Department of Internal Medicine, University of Genova and San Martino Hospital, Viale Benedetto XV, 6, 16132, Genoa, Italy.

Tyr78Phe is a rare pathogenic transthyretin (TTR) mutation. Few previous reports described a late-onset hereditary transthyretin-related amyloidosis (ATTR-m) form with a variable phenotype, mainly dominated by neurological manifestations. We describe the case of a 69-year-old male with massive but asymptomatic cardiac infiltration and only subclinical neurological involvement, and review the literature to depict characteristics of the Tyr78Phe TTR mutation. Read More

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http://link.springer.com/10.1007/s12265-018-9859-0
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http://dx.doi.org/10.1007/s12265-018-9859-0DOI Listing
January 2019
16 Reads

Exercise Improves the Function of Endothelial Cells by MicroRNA.

J Cardiovasc Transl Res 2019 Jan 2. Epub 2019 Jan 2.

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, 200444, China.

Vascular diseases induced by diabetes and obesity (e.g., atherosclerosis) are associated with insulin resistance (IR), which leads to endothelial cell dysfunction due to metabolic disorder and oxidative stress. Read More

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http://dx.doi.org/10.1007/s12265-018-9855-4DOI Listing
January 2019
1 Read

Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model.

J Cardiovasc Transl Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Biomedical Engineering, Texas A&M University, Mailstop 3120, College Station, TX, 77843-3120, USA.

While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist device was tested in six sheep using an acute heart failure model. High esmolol dose, targeting a 50% reduction in CO from healthy baseline, resulted in a failure state with mean CO 1. Read More

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http://dx.doi.org/10.1007/s12265-018-9854-5DOI Listing
January 2019
2 Reads

MicroRNA-29b-3p Targets SPARC Gene to Protect Cardiocytes against Autophagy and Apoptosis in Hypoxic-Induced H9c2 Cells.

J Cardiovasc Transl Res 2018 Dec 17. Epub 2018 Dec 17.

Second Department of Cardiology, Xinxiang Central Hospital, Xinxiang, Henan, China.

MicroRNAs participate in the regulation of abnormal cardiomyocyte apoptosis and autophagy, which leads to heart failure (HF). Lower miR-29b-3p levels were found in HF patients in this study. However, the role of miR-29b-3p in the molecular pathogenesis of HF remains unclear. Read More

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http://dx.doi.org/10.1007/s12265-018-9858-1DOI Listing
December 2018
1 Read

Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans.

J Cardiovasc Transl Res 2018 Dec 17. Epub 2018 Dec 17.

University of Oklahoma Health Sciences Center, 800 Stanton L Young Blvd Suite, Oklahoma City, OK, 5400, USA.

Low-level transcutaneous vagus nerve stimulation at the tragus (LLTS) is anti-adrenergic. We aimed to evaluate the acute effects of LLTS on left ventricular (LV) function and autonomic tone. Patients with diastolic dysfunction and preserved LV ejection fraction were enrolled in a prospective, randomized, double-blind, 2 × 2 cross-over study. Read More

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http://link.springer.com/10.1007/s12265-018-9853-6
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http://dx.doi.org/10.1007/s12265-018-9853-6DOI Listing
December 2018
7 Reads

Release of Mitochondrial and Nuclear DNA During On-Pump Heart Surgery: Kinetics and Relation to Extracellular Vesicles.

J Cardiovasc Transl Res 2018 Dec 12. Epub 2018 Dec 12.

Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Science, University of Oslo, Postbox 1103, Blindern, 0317, Oslo, Norway.

During heart surgery with cardiopulmonary bypass (CPB), the release of mitochondrial (mtDNA) and nuclear DNA (nDNA) and their association to extracellular vesicles were investigated. In patients undergoing elective coronary artery bypass grafting (CABG, n = 12), blood was sampled before, during, and after surgery from peripheral artery, pulmonary artery, and the coronary sinus. Plasma was separated in three fractions: microvesicles, exosomes, and supernatant. Read More

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http://dx.doi.org/10.1007/s12265-018-9848-3DOI Listing
December 2018
7 Reads

Identification and Functional Characterization of an ISL1 Mutation Predisposing to Dilated Cardiomyopathy.

J Cardiovasc Transl Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, Cardiovascular Research Laboratory, and Center for Complex Arrhythmias of Minhang District, The Fifth People's Hospital of Shanghai, Fudan University, No. 801 Heqing Road, Shanghai, 200240, China.

Dilated cardiomyopathy (DCM) is the most prevalent cause of non-ischemic cardiac failure and the commonest indication for cardiac transplantation. Compelling evidence highlights the pivotal roles of genetic defects in the occurrence of DCM. Nevertheless, the genetic determinants underpinning DCM remain largely obscure. Read More

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http://dx.doi.org/10.1007/s12265-018-9851-8DOI Listing
December 2018
2 Reads

Advance for Cardiovascular Health in China.

J Cardiovasc Transl Res 2018 Dec 7. Epub 2018 Dec 7.

Institute of Cardiovascular Sciences, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.

As the most populous country worldwide, China has ≈ 290 million patients with cardiovascular diseases (CVDs), representing the leading cause of death in Chinese population. The morbidity and mortality of CVDs are continuously rising. Here, we will first summarize the recent advance in the management of CVDs such as coronary arterial disease, arrhythmia, and heart failure in China. Read More

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http://dx.doi.org/10.1007/s12265-018-9852-7DOI Listing
December 2018
1 Read

Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design.

J Cardiovasc Transl Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

Improvements in ischemic heart disease (IHD) management have been unbalanced between sexes, with coronary microvascular dysfunction considered the likely underlying reason. The Endocrine Vascular disease Approach (EVA) is an observational study ( Clinicaltrial.gov NCT02737982) aiming to assess sex and gender interactions between coronary circulation, sexual hormones, and platelet function. Read More

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http://link.springer.com/10.1007/s12265-018-9846-5
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http://dx.doi.org/10.1007/s12265-018-9846-5DOI Listing
December 2018
13 Reads

Serum Extracellular Vesicles Retard H9C2 Cell Senescence by Suppressing miR-34a Expression.

J Cardiovasc Transl Res 2019 Feb 29;12(1):45-50. Epub 2018 Nov 29.

Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, 389 Xin Cun Road, Shanghai, 200065, China.

Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced cardiomyocytes senescence remains elusive. In this study, we found that human serum EVs inhibited DOX-induced senescence in H9C2 cells, which was abolished by miR-34a mimic. Read More

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http://dx.doi.org/10.1007/s12265-018-9847-4DOI Listing
February 2019
2 Reads

Comparative Quantification of Arterial Lipid by Intravascular Photoacoustic-Ultrasound Imaging and Near-Infrared Spectroscopy-Intravascular Ultrasound.

J Cardiovasc Transl Res 2018 Nov 28. Epub 2018 Nov 28.

Department of Cellular & Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, MS 385, Indianapolis, IN, 46202, USA.

Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo and ex vivo IVPA-US imaging of the iliac arteries of Ossabaw swine with metabolic syndrome (MetS) and lean swine to investigate sensitivity for early-stage atherosclerosis. We repeated imaging ex vivo with NIRS-IVUS for comparison to IVPA-US and histology. Read More

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http://link.springer.com/10.1007/s12265-018-9849-2
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http://dx.doi.org/10.1007/s12265-018-9849-2DOI Listing
November 2018
8 Reads

Splanchnic Circulation and Intraabdominal Metabolism in Two Porcine Models of Low Cardiac Output.

J Cardiovasc Transl Res 2018 Nov 19. Epub 2018 Nov 19.

Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University Hospital, SE-70185, Örebro, Sweden.

The impact of acute cardiac dysfunction on the gastrointestinal tract was investigated in anesthetized and instrumented pigs by sequential reductions of cardiac output (CO). Using a cardiac tamponade (n = 6) or partial inferior caval vein balloon inflation (n = 6), CO was controllably reduced for 1 h each to 75% (CO), 50% (CO), and 35% (CO) of the baseline value. Cardiac output in controls (n = 6) was not manipulated and maintained. Read More

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http://link.springer.com/10.1007/s12265-018-9845-6
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http://dx.doi.org/10.1007/s12265-018-9845-6DOI Listing
November 2018
20 Reads

Cardiac Progenitor Cell-Derived Extracellular Vesicles Reduce Infarct Size and Associate with Increased Cardiovascular Cell Proliferation.

J Cardiovasc Transl Res 2019 Feb 19;12(1):5-17. Epub 2018 Nov 19.

Laboratory of Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Centre, Leiden, The Netherlands.

Cell transplantation studies have shown that injection of progenitor cells can improve cardiac function after myocardial infarction (MI). Transplantation of human cardiac progenitor cells (hCPCs) results in an increased ejection fraction, but survival and integration are low. Therefore, paracrine factors including extracellular vesicles (EVs) are likely to contribute to the beneficial effects. Read More

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http://dx.doi.org/10.1007/s12265-018-9842-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394631PMC
February 2019
15 Reads

Identification of Radiofrequency Ablation Catheter Parameters That May Induce Intracardiac Steam Pops: Direct Visualization of Elicitation in Reanimated Swine Hearts.

J Cardiovasc Transl Res 2018 Nov 14. Epub 2018 Nov 14.

Department of Surgery and the Institute for Engineering in Medicine, University of Minnesota, 420 Delaware St. SE, B172 Mayo, MMC 195, Minneapolis, MN, 55455, USA.

Radiofrequency, a common ablation modality, is used clinically to terminate cardiac arrhythmias. With excessive heating, complications sometimes occur when the applied energy generates steam pops, which cause release of energy in the form of tissue and/or air emboli. In this study, we investigated numerous parameters potentially associated with intracardiac steam pops including (1) wattage, (2) catheter tip temperature, (3) catheter irrigation, (4) anatomic site, and (5) repeat ablations at a given site. Read More

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http://link.springer.com/10.1007/s12265-018-9844-7
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http://dx.doi.org/10.1007/s12265-018-9844-7DOI Listing
November 2018
17 Reads

Serum Uric Acid Is Independently Associated with Coronary Calcification in an Asymptomatic Population.

J Cardiovasc Transl Res 2018 Nov 9. Epub 2018 Nov 9.

Heart and Vascular Center, Semmelweis University, Városmajor Street 68, Budapest, H-1122, Hungary.

Detecting early-stage atherosclerosis is an important step towards cardiovascular disease prevention. Coronary artery calcium (CAC) score is a sensitive and non-invasive tool for detecting coronary atherosclerosis. Higher serum uric acid (SUA) levels are known to be associated with cardiovascular diseases. Read More

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http://link.springer.com/10.1007/s12265-018-9843-8
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http://dx.doi.org/10.1007/s12265-018-9843-8DOI Listing
November 2018
10 Reads

Immunomodulation by Exosomes in Myocardial Infarction.

J Cardiovasc Transl Res 2019 Feb 29;12(1):28-36. Epub 2018 Oct 29.

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.

Exosomes are important carriers of biological information that facilitate intercellular communication and participate in the pathophysiology of different cardiovascular diseases. Myocardial infarction is among the leading causes of death worldwide. Upon myocardial infarction, massive cardiomyocyte death triggers a strong inflammatory response which is a vital process of cardiac injury, repair, and remodeling. Read More

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http://dx.doi.org/10.1007/s12265-018-9836-7DOI Listing
February 2019
1 Read

Bioresorbable Scaffold-Based Controlled Drug Delivery for Restenosis.

J Cardiovasc Transl Res 2018 Oct 26. Epub 2018 Oct 26.

Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Ave., Bldg 22, Rm 4176, Silver Spring, MD, 20993, USA.

Bioresorbable scaffolds have emerged as a potential alternative to non-erodible metal implants to alleviate the long-term risk of permanent device vascular implant-related adverse events. Bioresorbable scaffolds provide a temporary mechanical support function until the vessel reaches complete healing, and the implant progressively disappears and vasomotion resumes. A polymer matrix with embedded drugs coated onto the scaffold surface degrades slowly, reducing the size from the exterior toward the interior, and this allows controlled drug release to a local vascular segment. Read More

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http://link.springer.com/10.1007/s12265-018-9841-x
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http://dx.doi.org/10.1007/s12265-018-9841-xDOI Listing
October 2018
16 Reads

Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury.

J Cardiovasc Transl Res 2018 12 26;11(6):503-516. Epub 2018 Oct 26.

Department of Cardiothoracic Surgery and Anesthesia, Uppsala University Hospital, SE-751 85, Uppsala, Sweden.

Surgery on the arch or descending aorta is associated with significant risk of neurological complications. As a consequence of intubation and sedation, early neurologic injury may remain unnoticed. Biomarkers to aid in the initial diagnostics could prove of great value as immediate intervention is critical. Read More

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http://link.springer.com/10.1007/s12265-018-9835-8
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http://dx.doi.org/10.1007/s12265-018-9835-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294830PMC
December 2018
19 Reads

Long-Term Weight Gain Associated With High Omentin Levels at Hospital Discharge Improves Prognosis of Patients Following Acute Heart Failure.

J Cardiovasc Transl Res 2018 Oct 23. Epub 2018 Oct 23.

Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.

A obesity paradox has been described following heart failure (HF). The aim of this study was to analyze the association between food intake-involved adipokines and long-term weight changes. Leptin, adiponectin, and omentin were analyzed in 92 acute HF (AHF) patients at discharge, classified on the basis of weight gains or losses > 6%. Read More

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http://dx.doi.org/10.1007/s12265-018-9840-yDOI Listing
October 2018
5 Reads

Stem Cell Homing: a Potential Therapeutic Strategy Unproven for Treatment of Myocardial Injury.

J Cardiovasc Transl Res 2018 10 15;11(5):403-411. Epub 2018 Oct 15.

Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, Jiangsu, People's Republic of China.

Despite advances in the prevention and therapeutic modalities of ischemic heart disease, morbidity and mortality post-infarction heart failure remain big challenges in modern society. Stem cell therapy is emerging as a promising therapeutic strategy. Stem cell homing, the ability of stem cells to find their destination, is receiving more attention. Read More

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http://link.springer.com/10.1007/s12265-018-9823-z
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http://dx.doi.org/10.1007/s12265-018-9823-zDOI Listing
October 2018
12 Reads

Does No-Touch Technique Better than Conventional or Intermediate Saphenous Vein Harvest Techniques for Coronary Artery Bypass Graft Surgery: a Systematic Review and Meta-analysis.

J Cardiovasc Transl Res 2018 12 12;11(6):483-494. Epub 2018 Oct 12.

Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Saphenous vein (SV) is a common graft being used in coronary artery bypass grafting (CABG). Conventional (CON), intermediate (I), and no-touch (NT) are the most common harvesting techniques of SV for CABG. The aim of this study is to systematically review the NT versus CON and I techniques in harvesting SV for CABG. Read More

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http://link.springer.com/10.1007/s12265-018-9832-y
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http://dx.doi.org/10.1007/s12265-018-9832-yDOI Listing
December 2018
12 Reads

A Simple Modified Framingham Scoring System to Predict Obstructive Coronary Artery Disease.

J Cardiovasc Transl Res 2018 12 12;11(6):495-502. Epub 2018 Oct 12.

Department of Cardiology, Provincial Key Laboratory of Coronary Heart Disease, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China.

Development of simple non-invasive risk prediction model would help in early prediction of coronary artery disease (CAD) reducing the burden on public health. This paper demonstrates a risk prediction scoring system to predict obstructive coronary artery disease (OCAD) in CAD patients. A total of 13,082 patients, referred for coronary angiography (CAG) in TRUST trial, were included in the development of a multivariable diagnostic prediction model. Read More

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http://link.springer.com/10.1007/s12265-018-9837-6
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http://dx.doi.org/10.1007/s12265-018-9837-6DOI Listing
December 2018
3 Reads

Interleukin-1 Receptor-Like 1 (IL1R1) Levels Are Not Increased in Healthy Centenarians.

J Cardiovasc Transl Res 2018 Oct 9. Epub 2018 Oct 9.

Servicio de Cardiología, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón. CIBERCV, Calle Doctor Esquerdo, 46, 28007, Madrid, Spain.

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http://link.springer.com/10.1007/s12265-018-9838-5
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http://dx.doi.org/10.1007/s12265-018-9838-5DOI Listing
October 2018
3 Reads