244 results match your criteria Journal of Carcinogenesis [Journal]


Molecular pathways of oral cancer that predict prognosis and survival: A systematic review.

J Carcinog 2018 31;17. Epub 2018 Dec 31.

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.

Several genes and pathways associated with oral squamous cell carcinoma (OSCC) are significant in terms of early detection and prognosis. The objective of this literature review is to evaluate the current research on molecular pathways and genes involved in oral cancer. Articles on the genes involved in oral cancer pathways were evaluated to identify potential biomarkers that can predict survival. Read More

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http://dx.doi.org/10.4103/jcar.JCar_17_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334533PMC
December 2018

A novel cancer syndrome caused by -deficiency in the golden Syrian hamster.

J Carcinog 2018 10;17. Epub 2018 Oct 10.

Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA.

Background: The golden Syrian hamster is an emerging model organism. To optimize its use, our group has made the first genetically engineered hamsters. One of the first genes that we investigated is which encodes for the KCNQ1 potassium channel and also has been implicated as a tumor suppressor gene. Read More

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http://www.carcinogenesis.com/text.asp?2018/17/1/6/243094
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http://dx.doi.org/10.4103/jcar.JCar_5_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187935PMC
October 2018
15 Reads

Role of aberrant glycosylation enzymes in oral cancer progression.

J Carcinog 2018 25;17. Epub 2018 Sep 25.

Department of Cancer Biology, Molecular Oncology Laboratory, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.

Background: Carcinogenesis, a multistep process involves sequential changes during neoplastic transformation. The various hallmarks of cancer aid in cell survival, proliferation, and dissemination. Aberrant glycosylation, a recently defined hallmark of cancer, is influenced by glycosylation enzymes during carcinogenesis. Read More

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http://dx.doi.org/10.4103/jcar.JCar_7_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166416PMC
September 2018
2 Reads

A case-control study on the association of abdominal obesity and hypercholesterolemia with the risk of colorectal cancer.

J Carcinog 2018 25;17. Epub 2018 Sep 25.

Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.

Background: Obesity has frequently been associated with the dyslipidemic state and with the risk of various chronic diseases.

Objective: The objective of this study was to determine the relationship between obesity and blood lipids with a risk of colorectal cancer (CRC).

Methodology: Histologically confirmed CRC patients from five local hospitals were matched with cancer-free controls for age, gender, and ethnicity ( = 140: 280). Read More

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http://dx.doi.org/10.4103/jcar.JCar_2_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166417PMC
September 2018
12 Reads

Genetic inhibition of autophagy in a transgenic mouse model of anal cancer.

J Carcinog 2018 23;17. Epub 2018 Jul 23.

Department of Surgery, University of Wisconsin, WI, USA.

Background: The dynamic role of autophagy in cancer development is a topic of considerable research and debate. Previously published studies have shown that anal cancer development can be promoted or prevented with the pharmacologic inhibition or induction, respectively, of autophagy in a human papillomavirus (HPV) mouse model. However, these results are confounded by the fact that the drugs utilized are known to affect other pathways besides autophagy. Read More

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http://dx.doi.org/10.4103/jcar.JCar_4_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071480PMC
July 2018
14 Reads

Oncogenic and tumor suppressive roles of special AT-rich sequence-binding protein.

J Carcinog 2018 5;17. Epub 2018 Apr 5.

Department of Environmental Medicine, New York University School of Medicine, NY, USA.

In recent years, research efforts have been centered on the functional roles of special AT-rich sequence-binding protein (SATB2) in cancer development. Existing studies differ in the types of tumor tissues and cell lines used, resulting in mixed results, which hinder the clear understanding of whether SATB2 acts as a tumor suppressor or promoter. Literature search for this review consisted of a basic search on PubMed using keywords "SATB2" and "special AT-rich sequence-binding protein 2. Read More

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http://www.carcinogenesis.com/text.asp?2018/17/1/2/229418
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http://dx.doi.org/10.4103/jcar.JCar_8_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071479PMC
April 2018
19 Reads

Evidence-based approaches to reduce cancer health disparities: Discover, develop, deliver, and disseminate.

J Carcinog 2018 28;17. Epub 2018 Feb 28.

Texas Center for Health Disparities, University of North Texas Health Science Center, Fort Worth 76107, Texas, USA.

The Texas Center for Health Disparities (TCHD) at the University of North Texas Health Science Center is a National Institute on Minority Health and Health Disparities-funded, specialized center of excellence for health disparities. TCHD organized its 12 annual conference focusing on "Evidence-Based Approaches to Reduce Cancer Health Disparities: Discover, Develop, Deliver, and Disseminate." At this conference, experts in health care, biomedical sciences, and public health gathered to discuss the current status and strategies for reducing cancer health disparities. Read More

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http://dx.doi.org/10.4103/jcar.JCar_13_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883827PMC
February 2018
4 Reads

The impact of gender, race, socioeconomic status, and treatment on outcomes in esophageal cancer: A population-based analysis.

J Carcinog 2017 18;16. Epub 2017 Sep 18.

Department of Medicine, Division of Hematology/Oncology, University of California, Irvine, CA, USA.

Background: African Americans and Hispanics are reported to have higher mortality from esophageal cancer (EC) than Caucasians. In this study, we analyzed the independent effects of race, gender, treatment, and socioeconomic status (SES) on overall survival (OS).

Methods: Data for all EC cases between 2004 and 2010 with follow-up through 2012 were obtained from the California Cancer Registry. Read More

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http://dx.doi.org/10.4103/jcar.JCar_4_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615860PMC
September 2017
4 Reads

Role of matrix metalloproteinase 13 gene expression in the evaluation of radiation response in oral squamous cell carcinoma.

J Carcinog 2017 19;16. Epub 2017 Jun 19.

Division of Developmental Toxicology, CSIR Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India.

Background: Matrix Metalloproteinase 13 (MMP13) is a member of collagenase family and it is involved in the degradation of extracellular matrix and basement membrane protein. It is thought to be associated with tumor invasion and metastasis. Elevated MMP13 expression has been found in carcinoma of the breast, urinary bladder, head and neck and others. Read More

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http://dx.doi.org/10.4103/jcar.JCar_5_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490341PMC
June 2017
40 Reads

Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis.

J Carcinog 2017 29;16. Epub 2017 May 29.

Department of Internal Medicine, Division of Oncology, University of Texas Health Science Center, McGovern Medical School, Houston, Texas, USA.

Since the 1970s, the epidemic of hepatocellular carcinoma (HCC) has spread beyond the Eastern Asian predominance and has been increasing in Northern hemisphere, especially in the United States (US) and Western Europe. It occurs more commonly in males in the fourth and fifth decades of life. Among all cancers, HCC is one of the fastest growing causes of death in the US and poses a significant economic burden on healthcare. Read More

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http://dx.doi.org/10.4103/jcar.JCar_9_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490340PMC
May 2017
18 Reads

The well-accepted notion that gene amplification contributes to increased expression still remains, after all these years, a reasonable but unproven assumption.

J Carcinog 2016 20;15. Epub 2016 May 20.

Department of Pathology, Guizhou Medical University Hospital, Guizhou, Guiyang 550004, P.R. China.

"Gene amplification causes overexpression" is a longstanding and well-accepted concept in cancer genetics. However, raking the whole literature, we find only statistical analyses showing a positive correlation between gene copy number and expression level, but do not find convincing experimental corroboration for this notion, for most of the amplified oncogenes in cancers. Since an association does not need to be an actual causal relation, in our opinion, this widespread notion still remains a reasonable but unproven assumption awaiting experimental verification. Read More

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http://dx.doi.org/10.4103/1477-3163.182809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895059PMC
June 2016
25 Reads

Antiangiogenic mechanisms and factors in breast cancer treatment.

J Carcinog 2016 12;15. Epub 2016 Feb 12.

Department of Molecular and Medical Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA; Institute for Cancer Research, Texas Center for Health Disparities, University of North Texas Health Science Center, Fort Worth, TX, USA.

Breast cancer is known to metastasize in its latter stages of existence. The different angiogenic mechanisms and factors that allow for its progression are reviewed in this article. Understanding these mechanisms and factors will allow researchers to design drugs to inhibit angiogenic behaviors and control the rate of tumor growth. Read More

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http://dx.doi.org/10.4103/1477-3163.176223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785777PMC
March 2016
4 Reads

Diagnostic utility of serum and pleural fluid carcinoembryonic antigen, and cytokeratin 19 fragments in patients with effusion from nonsmall cell lung cancer.

J Carcinog 2015 27;14. Epub 2015 Nov 27.

Department of Medicine, ASCOMS and Hospital, Jammu, Jammu and Kashmir, India.

Aims: To assess the diagnostic value of CEA and CYFRA 21-1 (cytokeratin 19 fragments) in serum and pleural fluid in non small cell lung cancer with malignant pleural effusion (MPE).

Settings And Design: Two subsets of patients were recruited with lymphocytic exudative effusion, one subset constituted diagnosed patients of NSCLC with malignant pleural effusion and the other subset of constituted with Tubercular pleural effusion.

Materials And Methods: CYFRA 21-1 and CEA levels were measured using Electrochemilumiscence Immunoassay (ECLIA). Read More

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http://dx.doi.org/10.4103/1477-3163.170662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736054PMC
February 2016
15 Reads
1 Citation

Role of genomics in eliminating health disparities.

J Carcinog 2015 11;14. Epub 2015 Sep 11.

Texas Center for Health Disparities, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.

The Texas Center for Health Disparities, a National Institute on Minority Health and Health Disparities Center of Excellence, presents an annual conference to discuss prevention, awareness education, and ongoing research about health disparities both in Texas and among the national population. The 2014 Annual Texas Conference on Health Disparities brought together experts in research, patient care, and community outreach on the "Role of Genomics in Eliminating Health Disparities." Rapid advances in genomics and pharmacogenomics are leading the field of medicine to use genetics and genetic risk to build personalized or individualized medicine strategies. Read More

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http://dx.doi.org/10.4103/1477-3163.165158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590179PMC
October 2015
5 Reads

Single nucleotide polymorphisms in CRTC1 and BARX1 are associated with esophageal adenocarcinoma.

J Carcinog 2015 21;14. Epub 2015 May 21.

Department of Pathology, Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The Netherlands.

Objective: Recently, single nucleotide polymorphisms (SNPs) associated with esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) were identified; rs10419226 (CRTC1), rs11789015 (BARX1), rs2687201 (FOXP1), rs2178146 (FOXF1), rs3111601 (FOXF1), and rs9936833 (FOXF1). These findings indicate that genetic susceptibility could play a role in the initiation of EAC in BE patients. The aim of this study was to validate the association between these previously identified SNPs and the risk of EAC in an independent and large case-control study. Read More

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http://dx.doi.org/10.4103/1477-3163.157441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453126PMC
June 2015
18 Reads

Molecular pathways to therapeutics: Paradigms and challenges in oncology meeting report: Carcinogenesis 2015.

J Carcinog 2015 21;14. Epub 2015 May 21.

Co-Investigator, Sarin Lab, ACTREC, Tata Memorial Centre, Navi Mumbai, Maharashtra, India.

The search for the most effective therapy with minimum side effects has always been the goal of oncologists and efforts to develop such therapies through understanding disease mechanisms has been the focus of many basic scientists in cancer research, leading to a common interest of convergence. The 5(th) International Conference organized by the Carcinogenesis Foundation, USA and Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, India, was held between February 11(th) and 13(th) 2015, at ACTREC. During these proceedings, the scientific community engaged in oncology research discussed novel ideas emerging from the laboratory and their translation into improved clinical outcomes. Read More

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http://www.carcinogenesis.com/text.asp?2015/14/1/4/157434
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http://dx.doi.org/10.4103/1477-3163.157434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453174PMC
June 2015
10 Reads

Pancreatic cystic neoplasms: Review of current knowledge, diagnostic challenges, and management options.

J Carcinog 2015 14;14. Epub 2015 Mar 14.

Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Pancreatic cystic lesions are being detected with increasing frequency, largely due to advances in cross-sectional imaging. The most common neoplasms include serous cystadenomas, mucinous cystic neoplasms, intraductal papillary mucinous neoplasms, solid pseudopapillary neoplasms, and cystic pancreatic endocrine neoplasms. Computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS) are currently used as imaging modalities. Read More

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http://dx.doi.org/10.4103/1477-3163.153285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374202PMC
March 2015
5 Reads

Cancer review: Cholangiocarcinoma.

J Carcinog 2015 23;14. Epub 2015 Feb 23.

Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Cholangiocarcinoma (CCA) is the most common biliary tract malignancy. CCA is classified as intrahepatic, perihilar or distal extrahepatic; the individual subtypes differ in their biologic behavior, clinical presentation, and management. Throughout the last decades, CCA incidence rates had significantly increased. Read More

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http://dx.doi.org/10.4103/1477-3163.151940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360553PMC
March 2015
4 Reads

Gastric cancer review.

J Carcinog 2014 19;13:14. Epub 2014 Dec 19.

Department of Hematology and Oncology Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.

Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Despite an overall decline in incidence over the last several decades, gastric cancer remains the fourth most common type of cancer and is the second leading cause of cancer-related death worldwide. This review aims to discuss the global distribution of the disease and the trend of decreasing incidence of disease, delineate the different pathologic subtypes and their immunohistochemical (IHC) staining patterns and molecular signatures and mutations, explore the role of the pathogen H. Read More

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http://www.carcinogenesis.com/text.asp?2014/13/1/14/146506
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http://dx.doi.org/10.4103/1477-3163.146506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278094PMC
January 2015
13 Reads

The advent of precision therapy in gastrointestinal malignancies: Targeting the human epidermal growth factor receptor family in colorectal and esophagogastric cancer.

J Carcinog 2014 27;13:13. Epub 2014 Nov 27.

Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada ; Department of Medical Oncology and Hematology, Cancer Care Manitoba, Winnipeg, MB R3E 0V9, Canada.

Until recently, systemic therapy for gastrointestinal malignancies was restricted to relatively noncancer-specific cytotoxic chemotherapy. Over the last 15 years targeted therapies have become available, most notably bevacizumab in the case of advanced colorectal cancer. Unfortunately, there are no predictive biomarkers to guide the use of this agent. Read More

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http://dx.doi.org/10.4103/1477-3163.145609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258725PMC
December 2014
5 Reads

Reducing inequities in colorectal cancer screening in North America.

J Carcinog 2014 14;13:12. Epub 2014 Nov 14.

Department of Community Health Sciences, University of Manitoba, Canada ; Department of Internal Medicine, University of Manitoba, Canada ; Department of Haematology and Medical Oncology, Cancer Care Manitoba, Canada.

Colorectal cancer (CRC) is an important cause of mortality and morbidity in North America. Screening using a fecal occult blood test, flexible sigmoidoscopy, or colonoscopy reduces CRC mortality through the detection and treatment of precancerous polyps and early stage CRC. Although CRC screening participation has increased in recent years, large inequities still exist. Read More

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http://dx.doi.org/10.4103/1477-3163.144576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253036PMC
December 2014
4 Reads

Esophageal cancer: Recent advances in screening, targeted therapy, and management.

J Carcinog 2014 30;13:11. Epub 2014 Oct 30.

Department of General Surgery, Weill Cornell Medical College of Cornell University, Houston Methodist Hospital, 6550 Fannin Street, Suite 1661, Houston, TX 77030, USA.

The incidence of esophageal cancer remains on the rise worldwide and despite aggressive research in the field of gastrointestinal oncology, the survival remains poor. Much remains to be defined in esophageal cancer, including the development of an effective screening tool, identifying a good tumor marker for surveillance purposes, ways to target esophageal cancer stem cells as well as circulating tumor cells, and developing minimally invasive protocols to treat early-stage disease. The goal of this chapter is to highlight some of the recent advances and ongoing research in the field of esophageal cancer. Read More

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http://dx.doi.org/10.4103/1477-3163.143720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229783PMC
November 2014
8 Reads

Expression of epidermal growth factor receptor, p53, Bcl2, vascular endothelial growth factor, cyclooxygenase-2, cyclin D1, human epidermal receptor-2 and Ki-67: Association with clinicopathological profiles and outcomes in gallbladder carcinoma.

J Carcinog 2014 25;13:10. Epub 2014 Aug 25.

Department of Laboratory Services, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Background: The present study observed the expression levels of epidermal growth factor receptor (EGFR), p53, Bcl2, vascular endothelial growth factor (VEGF), cyclooxygenase-2 (cox-2), cyclin D1, human epidermal receptor-2 (HER-2) and Ki-67 in gallbladder carcinoma (GBC) and their association with clinicopathological profiles and disease outcomes.

Materials And Methods: Fifty consecutive samples of cholecystectomy/biopsies from GB bed (archived formalin fixed paraffin embedded tissue blocks of different stages of GBC) were included, and patient details related to their demographic profile, investigations, tumor profile, treatment, and follow-up were recorded. Immunohistochemistry was performed to study the expression levels. Read More

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http://dx.doi.org/10.4103/1477-3163.139450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163917PMC
September 2014
9 Reads
3 Citations

Doenjang prepared with mixed starter cultures attenuates azoxymethane and dextran sulfate sodium-induced colitis-associated colon carcinogenesis in mice.

J Carcinog 2014 29;13. Epub 2014 Jul 29.

Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Korea.

Backgrounds: Doenjang is traditional Korean fermented soybean paste and widely known for its various health benefits including anticancer effect. In this study, we manufactured doenjang with the grain-type meju using probiotic mixed starter cultures of Aspegillus oryzae, Bacillus subtilis-SKm, and Lactococcus lactis-GAm to improve the qualities and beneficial properties of doenjang.

Materials And Methods: The inhibitory effects of the doenjang prepared with the grain-type meju using mixed starter cultures were investigated in azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced colon carcinogenesis mice model. Read More

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http://dx.doi.org/10.4103/1477-3163.137699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141357PMC
September 2014
20 Reads

Circulating tumor cells in breast cancer.

J Carcinog 2014 30;13. Epub 2014 Jun 30.

Department of Medicine, Hematology Oncology Division, Miller School of Medicine, Miami, FL, USA ; Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.

Circulating tumor cell (CTC) measurement in peripheral blood of patients with breast cancer offers prognostic information. In this review, we will try to identify evidence that could be used for prognosis, predictive power to draw this tool to clinical utility. We reviewed 81 manuscripts, and categorized those in discovery datasets, prognostic factors in metastatic breast cancer, identification of clinical utility in early breast cancer and in novel approaches. Read More

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http://dx.doi.org/10.4103/1477-3163.135578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141360PMC
September 2014
10 Reads

Inhibitory potential of methanolic extracts of Aristolochia tagala and Curcuma caesia on hepatocellular carcinoma induced by diethylnitrosamine in BALB/c mice.

J Carcinog 2014 30;13. Epub 2014 May 30.

Cancer and Radiation Countermeasures Unit, Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, India.

Context: Aristolochia tagala (AT) and Curcuma caesia (CC) have been used traditionally by local herbal practitioners for cancer treatment and as chief ingredients of many polyherbal formulations for various types of ailments. However, there is void in scientific study to evaluate their anti-cancer property.

Aims: The aim of this study was to evaluate the anti-carcinogenic properties of the crude methanolic extracts of roots of AT and rhizomes of CC in BALB/c mice exposed to a hepatocarcinogen, diethylnitrosamine (DEN). Read More

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http://dx.doi.org/10.4103/1477-3163.133520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141361PMC
September 2014
4 Reads

Systems oncology: A new paradigm in cancer research.

Authors:
Gopala Kovvali

J Carcinog 2014 11;13. Epub 2014 Mar 11.

Editor-in-Chief, Journal of Carcinogenesis, Adjunct Professor, Graduate School of Biomedical Sciences, UNTHSC, Fort Worth, TX, USA.

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http://dx.doi.org/10.4103/1477-3163.128641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007382PMC
May 2014
4 Reads

Novel agents in the management of castration resistant prostate cancer.

J Carcinog 2014 5;13. Epub 2014 Mar 5.

Department of Solid Tumor Oncology, Cleveland Clinic, Taussig Cancer Institute and Glickman Urological and Kidney Institute, Cleveland, Ohio 44195, USA ; Department of Urology, Cleveland Clinic, Taussig Cancer Institute and Glickman Urological and Kidney Institute, Cleveland, Ohio 44195, USA.

Prostate cancer (PCa) is a leading cause of cancer mortality in men and despite high cure rates with surgery and/or radiation, 30-40% of patients will eventually develop advanced disease. Androgen deprivation is the first line therapy for standard of care for men with advanced disease. Eventually however all men will progress to castration-resistant prostate cancer (CRPC). Read More

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http://dx.doi.org/10.4103/1477-3163.128185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007389PMC
June 2014
4 Reads
7 Citations

Targeted therapy in gastrointestinal malignancies.

J Carcinog 2014 20;13. Epub 2014 Feb 20.

Department of Medicine, Division of Medical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.

Increased understanding of cancer pathogenesis has identified several pathways that serve as potential targets for novel targeted agents in development. The selection of targeted cancer therapy based on biomarkers has instigated a new era of personalized medicine and changed the way we practice oncology. Many targeted agents are approved for treatment of gastrointestinal malignancies most targeting tumor angiogenesis, and many more are in different phases of development. Read More

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http://dx.doi.org/10.4103/1477-3163.127639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986534PMC
June 2014
4 Reads

Targeted therapy for renal cell carcinoma: The next lap.

J Carcinog 2014 20;13. Epub 2014 Feb 20.

Department of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Republic of Singapore ; Institute of Bioengineering and Nanotechnology, Singapore 138669, Republic of Singapore.

Advances in rationally targeted therapeutics over the last decade have transformed the clinical care of advanced kidney cancer. While oncologists consolidate the gains of the wave of new agents, comprising a panoply of anti-vascular endothelial growth factor multi-targeted tyrosine kinase inhibitors and inhibitors of the mammalian target of rapamycin (mTOR), there is an increasing sense that a plateau has been reached in the short term. It is sobering that all currently approved targeted therapies have not yielded durable remissions and remain palliative in intent. Read More

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http://dx.doi.org/10.4103/1477-3163.127638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986548PMC
June 2014
5 Reads

Antisense oligonucleotides directed against insulin-like growth factor-II messenger ribonucleic acids delay the progress of rat hepatocarcinogenesis.

J Carcinog 2014 7;13. Epub 2014 Feb 7.

Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.

Background: Hepatocellular carcinoma (HCC) is a multistep complex process, caused by many of genetic alteration. Insulin-like growth factors and their receptor have been widely implicated to HCC. Insulin-like growth factor-II (IGF-II) is a mitogenic polypeptide, found in various fetal and neonatal tissues of humans and rats and expresses in HCC. Read More

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http://www.carcinogenesis.com/text.asp?2014/13/1/2/126761
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http://dx.doi.org/10.4103/1477-3163.126761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986617PMC
April 2014
7 Reads

BRAF and beyond: Tailoring strategies for the individual melanoma patient.

J Carcinog 2014 7;13. Epub 2014 Feb 7.

Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.

Until recently, options for therapy in metastatic melanoma were limited. The understanding of immune check-point blockade and the discovery of molecular pathways involving driver mutations like BRAF has transformed the therapeutic landscape in this disease. Ipilimumab was the first drug shown to improve survival while vemurafenib demonstrated rapid responses never seen before in melanoma. Read More

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http://dx.doi.org/10.4103/1477-3163.126759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986540PMC
June 2014
5 Reads

Targeted therapies in development for non-small cell lung cancer.

J Carcinog 2013 31;12:22. Epub 2013 Dec 31.

Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

The iterative discovery in various malignancies during the past decades that a number of aberrant tumorigenic processes and signal transduction pathways are mediated by "druggable" protein kinases has led to a revolutionary change in drug development. In non-small cell lung cancer (NSCLC), the ErbB family of receptors (e.g. Read More

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http://dx.doi.org/10.4103/1477-3163.123972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927069PMC
June 2014
4 Reads

p53 and regulation of tumor metabolism.

J Carcinog 2013 Nov 6;12:21. Epub 2013 Nov 6.

Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.

The tumor suppressor p53 plays a pre-eminent role in protecting against cancer, through its ability to sense various stresses and in turn invoke anti-proliferative and repair responses. Emerging evidence suggest that p53 is both a central sentinel for metabolic stresses and a master regulator of metabolic fluxes. This newly identified function of p53, along with the ability of p53 to induce senescence, appears to be crucial for the prevention of oncogenic transformation. Read More

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http://dx.doi.org/10.4103/1477-3163.122760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869960PMC
November 2013
5 Reads

O-6-methylguanine-deoxyribonucleic acid methyltransferase methylation enhances response to temozolomide treatment in esophageal cancer.

J Carcinog 2013 28;12:20. Epub 2013 Oct 28.

Department of Medicine, The University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL, USA.

Background: World-wide, esophageal cancer is a growing epidemic and patients frequently present with advanced disease that is surgically inoperable. Hence, chemotherapy is the predominate treatment. Cytotoxic platinum compounds are mostly used, but their efficacy is only moderate. Read More

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http://dx.doi.org/10.4103/1477-3163.120632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853796PMC
December 2013
16 Reads

Obesity, metabolism and the microenvironment: Links to cancer.

J Carcinog 2013 Oct 9;12:19. Epub 2013 Oct 9.

Department of Nutrition, Nutrition Obesity Research Center, and Lineberger Comprehensive Cancer Center, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Drive, CB #7461, Chapel Hill, NC, 27599, USA.

Historically, cancer research has focused on identifying mutations or amplification of genes within the tumor, which informed the development of targeted therapies against affected pathways. This work often considers tumor cells in isolation; however, it is becoming increasingly apparent that the microenvironment surrounding tumor cells strongly influences tumor onset and progression. This is the so-called "seed and soil" hypothesis wherein the seed (cancer cell) is fed and molded by the metabolites, growth factors, modifications of the extracellular matrix or angiogenic factors provided by the soil (or stroma). Read More

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http://dx.doi.org/10.4103/1477-3163.119606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816318PMC
October 2013
18 Reads

Intersection of Smoking, Human immunodeficiency virus/acquired immunodeficiency syndrome and Cancer: Proceedings of the 8(th) Annual Texas Conference on Health Disparities.

J Carcinog 2013 Oct 5;12:18. Epub 2013 Oct 5.

Texas Center for Health Disparities and The Institute for Cancer Research, UNT Health Science Center, Fort Worth, Texas, USA.

The Texas Center for Health Disparities, a National Institute on Minority Health and Health Disparities Center of Excellence, presents an annual conference to discuss prevention, awareness education and ongoing research about health disparities both in Texas and among the national population. The 2013 Texas Conference on Health Disparities brought together experts, in research, patient care and community outreach, on the "Intersection of Smoking, Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and Cancer". Smoking, HIV/AIDS and cancer are three individual areas of public health concern, each with its own set of disparities and risk factors based on race, ethnicity, gender, geography and socio-economic status. Read More

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http://dx.doi.org/10.4103/1477-3163.119388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814655PMC
October 2013
6 Reads

Dealing with hunger: Metabolic stress responses in tumors.

J Carcinog 2013 Sep 30;12:17. Epub 2013 Sep 30.

Department of Cancer Biology, Beckman Research Institute of City of Hope Cancer Center, Duarte, CA 91010, USA.

Increased nutrient uptake and usage is a hallmark of many human malignancies. During the course of tumorigenesis, cancer cells often outstrip their local nutrient supply leading to periods of nutrient deprivation. Interestingly, cancer cells often develop strategies to adapt and survive these challenging conditions. Read More

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http://dx.doi.org/10.4103/1477-3163.119111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816312PMC
September 2013
3 Reads

Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor.

J Carcinog 2013 Aug 8;12:16. Epub 2013 Aug 8.

Department of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA.

The liver kinase B1 (LKB1) tumour suppressor functions as a master regulator of growth, metabolism and survival in cells, which is frequently mutated in sporadic human non-small cell lung and cervical cancers. LKB1 functions as a key upstream activator of the AMP-activated protein kinase (AMPK), a central metabolic switch found in all eukaryotes that govern glucose and lipid metabolism and autophagy in response to alterations in nutrients and intracellular energy levels. The LKB1/AMPK signalling pathway suppresses mammalian target of rapamycin complex 1 (mTORC1), an essential regulator of cell growth in all eukaryotes that is deregulated in a majority of human cancers. Read More

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http://dx.doi.org/10.4103/1477-3163.116323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779404PMC
August 2013
4 Reads

Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach.

J Carcinog 2013 26;12:15. Epub 2013 Jul 26.

Office of the Associate Director for Regulatory Activities, Jefferson, AR 72079, USA.

It is well established that transcriptional silencing of critical tumor-suppressor genes by DNA methylation is a fundamental component in the initiation of breast cancer. However, the involvement of microRNAs (miRNAs) in restoring abnormal DNA methylation patterns in breast cancer is not well understood. Therefore, we investigated whether miRNA-29b, due to its complimentarity to the 3'- untranslated region of DNA methyltransferase 3A (DNMT3A) and DNMT3B, could restore normal DNA methylation patterns in human breast cancers and breast cancer cell lines. Read More

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http://dx.doi.org/10.4103/1477-3163.115720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746452PMC
August 2013
8 Reads

Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator.

Authors:
Fabian V Filipp

J Carcinog 2013 24;12:14. Epub 2013 Jul 24.

Systems Biology and Cancer Metabolism, Program for Quantitative and Systems Biology, University of California Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Pyruvate kinase activity is controlled by a tightly woven regulatory network. The oncofetal isoform of pyruvate kinase (PKM2) is a master regulator of cancer metabolism. PKM2 engages in parallel, feed-forward, positive and negative feedback control contributing to cancer progression. Read More

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http://dx.doi.org/10.4103/1477-3163.115423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746496PMC
August 2013
6 Reads

Mapping cancer cell metabolism with(13)C flux analysis: Recent progress and future challenges.

J Carcinog 2013 24;12:13. Epub 2013 Jul 24.

Department of Chemical and Biomolecular Engineering, PMB 351604, 2301 Vanderbilt Place, Vanderbilt University, Nashville, TN 37235-1604, USA.

The reprogramming of energy metabolism is emerging as an important molecular hallmark of cancer cells. Recent discoveries linking specific metabolic alterations to cancer development have strengthened the idea that altered metabolism is more than a side effect of malignant transformation, but may in fact be a functional driver of tumor growth and progression in some cancers. As a result, dysregulated metabolic pathways have become attractive targets for cancer therapeutics. Read More

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http://dx.doi.org/10.4103/1477-3163.115422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746411PMC
August 2013
4 Reads

Epidermal growth factor receptor mutation in lung adenocarcinoma in India: A single center study.

J Carcinog 2013 12;12:12. Epub 2013 Jul 12.

Department of Medical Oncology, Research, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India ; Department of Research, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Background: Adenocarcinoma, a subgroup of non-small cell lung cancer, is the most frequent form occurring in the non-smokers. Mutation in tyrosine kinase domain of epidermal growth factor receptor (EGFR) has been a common feature observed in lung adenocarcinoma. The study was carried out to detect the prevalence of EGFR mutation in lung adenocarcinoma. Read More

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http://dx.doi.org/10.4103/1477-3163.114970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746453PMC
August 2013
9 Reads
9 Citations

Effects of maternal dietary exposure to cadmium during pregnancy on mammary cancer risk among female offspring.

J Carcinog 2013 29;12:11. Epub 2013 Jun 29.

Department of Oncology, Lombardi Comprehensive Cancer Center, Washington, DC 20057, USA ; Tumor Biology Graduate Program, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20057, USA.

Background: Since heavy metal cadmium is an endocrine disrupting chemical, we investigated whether maternal exposure to cadmium during the pregnancy alters mammary tumorigenesis among female offspring.

Methods: From gestation day 10 to day 19, pregnant rat dams were fed modified American Institute of Nutrition (AIN93G) diet containing 39% energy from fat (baseline diet), or the baseline diet containing moderate (75 μg/kg of feed) or high (150 μg/kg) cadmium levels. Some dams were injected with 10 μg 17β-estradiol (E2) daily between gestation days 10 and 19. Read More

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http://dx.doi.org/10.4103/1477-3163.114219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709380PMC
July 2013
15 Reads

Stage-specific analysis of plasma protein profiles in ovarian cancer: Difference in-gel electrophoresis analysis of pooled clinical samples.

J Carcinog 2013 29;12:10. Epub 2013 Jun 29.

Zoetis, Veterinary Medicine Research and Development, Melbourne, Australia.

Introduction: Ovarian cancer is the leading cause of death from gynecological cancer. Non-specific symptoms early in disease and the lack of specific biomarkers hinder early diagnosis. Multi-marker blood screening tests have shown promise for improving identification of early stage disease; however, available tests lack sensitivity, and specificity. Read More

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http://dx.doi.org/10.4103/1477-3163.114216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709370PMC
July 2013
10 Reads

Applications of metabolomics in cancer research.

J Carcinog 2013 18;12. Epub 2013 Jun 18.

School of Chemical & Biomolecular Engineering and Institute for Bioengineering & Bioscience, Georgia Institute of Technology, 311 Ferst Dr. NW, Atlanta, GA 30332-0100, USA.

The first discovery of metabolic changes in cancer occurred almost a century ago. While the genetic underpinnings of cancer have dominated its study since then, altered metabolism has recently been acknowledged as a key hallmark of cancer and metabolism-focused research has received renewed attention. The emerging field of metabolomics - which attempts to profile all metabolites within a cell or biological system - is now being used to analyze cancer metabolism on a system-wide scale, painting a broad picture of the altered pathways and their interactions with each other. Read More

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http://dx.doi.org/10.4103/1477-3163.113622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709411PMC
July 2013
4 Reads

Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression.

J Carcinog 2013 20;12. Epub 2013 May 20.

Department of Anatomy, Physiology, and Genetics, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Background: Cardiac glycosides such as digitoxin have been shown to directly cause apoptotic death of cancer cells both in vitro, and in vivo. However, the mechanism connecting cardiac glycoside action to apoptosis is not known. It has been reported that compounds resembling digitoxin are able to reduce c-MYC expression. Read More

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http://dx.doi.org/10.4103/1477-3163.112268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709410PMC
July 2013
6 Reads

Targeted agents in non-small cell lung cancer therapy: What is there on the horizon?

J Carcinog 2013 18;12. Epub 2013 Mar 18.

Department of Medicine, Section of Hematology/Oncology University of Chicago, Chicago, IL, USA.

Lung cancer is a heterogeneous group of diseases. There has been much research in lung cancer over the past decade which has advanced our ability to treat these patients with a more personalized approach. The scope of this paper is to review the literature and give a broad understanding of the current molecular targets for which we currently have therapies as well as other targets for which we may soon have therapies. Read More

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http://dx.doi.org/10.4103/1477-3163.109253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622362PMC
April 2013
5 Reads

Cell of origin of lung cancer.

J Carcinog 2013 16;12. Epub 2013 Mar 16.

Department of Surgery, Duke University Medical Center, Durham.

Lung cancer is the leading cause of cancer deaths worldwide, and current therapies are disappointing. Elucidation of the cell(s) of origin of lung cancer may lead to new therapeutics. In addition, the discovery of putative cancer-initiating cells with stem cell properties in solid tumors has emerged as an important area of cancer research that may explain the resistance of these tumors to currently available therapeutics. Read More

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http://dx.doi.org/10.4103/1477-3163.109033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622445PMC
April 2013
4 Reads