1,649 results match your criteria Journal of Bone and Mineral Metabolism [Journal]


Ryo Okazaki, MD, PhD : October 6, 1960 to August 5, 2018.

Authors:
Toshio Matsumoto

J Bone Miner Metab 2019 Feb 13. Epub 2019 Feb 13.

Fujii Memorial Institute of Medical Sciences, University of Tokushima, Tokushima, Japan.

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http://dx.doi.org/10.1007/s00774-019-00992-3DOI Listing
February 2019

Modulation of bone turnover by Cissus quadrangularis after ovariectomy in rats.

J Bone Miner Metab 2019 Feb 12. Epub 2019 Feb 12.

Department of Health and Biomedical Sciences, University of Texas Rio Grande Valley, 1201, W University Dr., Edinburg, TX, 78539, USA.

In women, age-related bone loss is associated with increased risk of bone fracture. Existing therapies are associated with severe side effects; thus, there is a need to find alternative medicines with less or optimal side effects. Cissus quadrangularis (CQ), an Ayurvedic medicine used to enhance fracture healing, was tested for its bone protective properties and studied to discern the mechanism by which it is beneficial to bone. Read More

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http://dx.doi.org/10.1007/s00774-018-0983-3DOI Listing
February 2019

A simple questionnaire for the prediction of vitamin D deficiency in Japanese adults (Vitaimn D Deficiency questionnaire for Japanese: VDDQ-J).

J Bone Miner Metab 2019 Feb 5. Epub 2019 Feb 5.

Department of Faculty of Nutrition, Kobe Gakuin University, 518, Ikawadanicho-Arise, Nishi-ku, Kobe, Hyogo, 651-2180, Japan.

Vitamin D deficiency (VDD) is associated with an increased risk of various diseases. Serum 25-hydroxyvitamin D [25(OH)D] concentration is the best marker for vitamin D status and its concentration < 20 ng/mL indicates VDD. However, its measurement is not easily applicable for the evaluation of vitamin D status in the general population because of its cost. Read More

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http://dx.doi.org/10.1007/s00774-018-0984-2DOI Listing
February 2019

ALPL mutations in adults with rheumatologic disorders and low serum alkaline phosphatase activity.

J Bone Miner Metab 2019 Feb 4. Epub 2019 Feb 4.

Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.

Tissue-nonspecific alkaline phosphatase (ALP), encoded by ALPL, is important for bone homeostasis and interacts with collagen type I. In the present study, we sequenced ALPL and a panel of collagen type I-related genes in 24 adults (age 22-80 years; 20 female) with persistently low serum ALP (< 40 U/L) and a range of rheumatologic symptoms. We found heterozygous pathogenic or likely pathogenic variants in ALPL in 14 (58%) of these individuals. Read More

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http://dx.doi.org/10.1007/s00774-019-00991-4DOI Listing
February 2019

Incidence of osteonecrosis of the jaw in Japanese osteoporosis patients taking minodronic acid.

J Bone Miner Metab 2019 Feb 4. Epub 2019 Feb 4.

Department of Internal Medicine, Research Institute and Practice for Involutional Diseases, 1610-1 Meisei, Misato, Azumino, Nagano, 399-8101, Japan.

Osteonecrosis of the jaw (ONJ) associated with bisphosphonate therapy is a rare but severe side effect in osteoporosis patients. Recently, the number of osteoporosis patients with ONJ has dramatically increased in Japan. This has contributed to an increase in the number of patients avoiding extractions. Read More

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http://dx.doi.org/10.1007/s00774-019-00990-5DOI Listing
February 2019
2 Reads

Novel bisphosphonate compound FYB-931 preferentially inhibits aortic calcification in vitamin D3-treated rats.

J Bone Miner Metab 2019 Feb 2. Epub 2019 Feb 2.

Research Laboratories 2, Fuji Yakuhin Co., Ltd., 636-1 Iidashinden, Nishi-ku, Saitama, Saitama, 331-0068, Japan.

In patients with chronic kidney disease (CKD) or those undergoing hemodialysis, pathological calcific deposition known as ectopic calcification occurs in soft tissue, resulting in a life-threatening disorder. A potent and effective inhibitor of ectopic calcification is eagerly expected. In the current study, the effects of FYB-931, a novel bisphosphonate compound synthesized for the prevention of ectopic calcification, were compared with those of etidronate using both in vitro and in vivo models. Read More

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http://dx.doi.org/10.1007/s00774-019-00987-0DOI Listing
February 2019

Preventative effects of metformin on glucocorticoid-induced osteoporosis in rats.

J Bone Miner Metab 2019 Jan 31. Epub 2019 Jan 31.

Department of Nephrology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, People's Republic of China.

This study evaluated the preventative effects of metformin (Met) on glucocorticoid (GC)-induced osteoporosis in a rat model, compared with alendronate (Aln). Twenty-eight 3-month-old female Sprague-Dawley rats were randomly assigned into four groups: normal control (Ctr), methylprednisolone (MP, 13 mg/kg/day, sc, 5 days per week), MP plus Aln orally (1 mg/kg/day), and MP plus Met orally (200 mg/kg/day). After 9 weeks, serum bone metabolic biochemistry, bone densitometry and histomorphometry were performed. Read More

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http://dx.doi.org/10.1007/s00774-019-00989-yDOI Listing
January 2019
1 Read

Accumulation of microdamage in subchondral bone at the femoral head in patients with end-stage osteoarthritis of the hip.

J Bone Miner Metab 2019 Jan 30. Epub 2019 Jan 30.

Department of Orthopaedic Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

In end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear. In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femoral heads were evaluated in 10 women who underwent total hip arthroplasty for OA and in nine cadaveric controls (CNT). Read More

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http://dx.doi.org/10.1007/s00774-019-00988-zDOI Listing
January 2019
1 Read

Psoas cross-sectional area as a predictor of mortality and a diagnostic tool for sarcopenia in hip fracture patients.

J Bone Miner Metab 2019 Jan 8. Epub 2019 Jan 8.

Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-ku, Seoul, 06973, Republic of Korea.

This study aimed to determine: (1) the association between psoas cross-sectional area (PCA) and mortality in hip fracture patients, and (2) the usefulness of PCA as a diagnostic tool for sarcopenia. A total of 373 female and 121 male hip fracture patients aged 50 years or more who had surgical repair of their hip fracture between 2011 and 2017 were analyzed. PCA was measured at L4-L5 disc level using CT. Read More

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http://link.springer.com/10.1007/s00774-019-00986-1
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http://dx.doi.org/10.1007/s00774-019-00986-1DOI Listing
January 2019
2 Reads

Differences in prevalence and associated factors between mild and severe vertebral fractures in Japanese men and women: the third survey of the ROAD study.

J Bone Miner Metab 2019 Jan 3. Epub 2019 Jan 3.

Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical and Research Center, The University of Tokyo Hospital, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.

Vertebral fracture (VF) is a common osteoporotic fracture, while its epidemiology varies according to regions and ethnicities, little is known about it in Japan. Using whole-spine radiographs from a population-based cohort study, the Research on Osteoarthritis/Osteoporosis Against Disability study 3rd survey performed in 2012-2013, we estimated the sex- and age-specific prevalence of VF in the Japanese. Genant's semiquantitative method (SQ) was used to define VF; SQ ≥ 1 as VF, SQ = 1 as mild VF, SQ≥ 2 as severe VF. Read More

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http://link.springer.com/10.1007/s00774-018-0981-5
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http://dx.doi.org/10.1007/s00774-018-0981-5DOI Listing
January 2019
5 Reads

Pigment epithelium-derived factor (PEDF) reduced expression and synthesis of SOST/sclerostin in bone explant cultures: implication of PEDF-osteocyte gene regulation in vivo.

J Bone Miner Metab 2019 Jan 3. Epub 2019 Jan 3.

Department of Orthopaedics and Rehabilitation H089, Penn State College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.

Mutations in Serpinf1 gene which encodes pigment epithelium-derived factor (PEDF) lead to osteogenesis imperfecta type VI whose hallmark is defective matrix mineralization. We reported previously that PEDF reduced expression and synthesis of Sost/Sclerostin as well as other osteocytes genes encoding proteins that regulate matrix mineralization [1]. To determine whether PEDF had an effect on osteocyte gene expression in bone, we used bone explant cultures. Read More

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http://dx.doi.org/10.1007/s00774-018-0982-4DOI Listing
January 2019
2.460 Impact Factor

Metabolic characteristics of subjects with spine-femur bone mineral density discordances: the Korean National Health and Nutrition Examination Survey (KNHANES 2008-2011).

J Bone Miner Metab 2019 Jan 3. Epub 2019 Jan 3.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

The diagnosis of osteoporosis is determined based on the lowest bone mineral density (BMD) T-score at the lumbar spine (LS) and hip. However, there are occasional marked discordances between the T-score of LS and femur neck (FN). We aimed to examine the prevalence and characteristics of individuals with spine-femur BMD discordance using a nationwide survey. Read More

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http://dx.doi.org/10.1007/s00774-018-0980-6DOI Listing
January 2019
2 Reads

Efficacy and safety of once-monthly risedronate in osteoporosis subjects with mild-to-moderate chronic kidney disease: a post hoc subgroup analysis of a phase III trial in Japan.

J Bone Miner Metab 2018 Dec 6. Epub 2018 Dec 6.

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.

Limited data are available on the safety and efficacy of anti-resorptive agents, particularly once-monthly bisphosphonates, for use in osteoporotic patients with chronic kidney disease (CKD). We conducted a post hoc analysis of data from a 12-month, randomized, double-blind, phase III study to evaluate the safety and efficacy of once-monthly risedronate (RIS-OM) 75 mg tablets in Japanese osteoporosis patients with mild-to-moderate CKD. Patients who received RIS-OM 75 mg were stratified by baseline estimated glomerular filtration rate (eGFR; ≥ 90, ≥ 60 to < 90, or ≥ 30 to < 60 mL/min/1. Read More

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http://dx.doi.org/10.1007/s00774-018-0977-1DOI Listing
December 2018
2 Reads

Serum level vitamin D and parathyroid hormone, and mortality, with or without chronic kidney disease.

J Bone Miner Metab 2018 Dec 7. Epub 2018 Dec 7.

Department of Preventive Medicine, Chonnam National University Medical School, 264, Seoyang-ro Hwasun-eup, Hwasun, 58128, Jeollanam-do, Korea.

Levels of vitamin D and parathyroid hormone (PTH) are closely associated with renal function. We evaluated the associations among 25-hydroxyvitamin D (25OHD) levels, PTH levels, and mortality, and whether these associations varied by renal function. We used data from the Dong-gu Study, a population-based cohort in Korean adults. Read More

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http://dx.doi.org/10.1007/s00774-018-0979-zDOI Listing
December 2018
2 Reads

Differences in the relation between bone mineral content and lean body mass according to gender and reproductive status by age ranges.

J Bone Miner Metab 2018 Dec 4. Epub 2018 Dec 4.

Unidad Académica en Investigación Epidemiológica, Centro de Investigación en Políticas, Población y Salud, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.

The present study aims: (1) to explore the influence of lean mass (LM) on bone mineral content (BMC), (2) to investigate the pubertal influences on the BMC-LM relation, and (3) to perform Z-score charts of BMC-LM relation, stratified by gender and reproductive status categorized by age ranges. A cross-sectional analysis was conducted using 4001 healthy subjects between 7 and 90 years participating in the Health Workers Cohort Study. Of these, 720 participants were ≤ 19 years, 2417 were women ≥ 20 years, and 864 were men ≥ 20 years. Read More

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http://link.springer.com/10.1007/s00774-018-0978-0
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http://dx.doi.org/10.1007/s00774-018-0978-0DOI Listing
December 2018
9 Reads

Effect of RAB31 silencing on osteosarcoma cell proliferation and migration through the Hedgehog signaling pathway.

J Bone Miner Metab 2018 Nov 23. Epub 2018 Nov 23.

Department of Hematology and Oncology, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Changchun, 130041, Jilin, People's Republic of China.

Osteosarcoma (OS) is a prevalent cancer that plagues people worldwide. Identifying prognostic markers would be useful in treating human OS. In this study, we aimed to explore the functions of Ras-related protein Rab-31 (RAB31) in OS-cell proliferation, migration, and invasion as well as its roles in the Hedgehog signaling pathway for better understanding of the mechanism. Read More

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http://dx.doi.org/10.1007/s00774-018-0961-9DOI Listing
November 2018
8 Reads
2.460 Impact Factor

Quantitation and distribution of metallic elements in sequestra of medication-related osteonecrosis of jaw (MRONJ) using inductively coupled plasma atomic emission spectroscopy and synchrotron radiation X-ray fluorescence analysis.

J Bone Miner Metab 2018 Nov 22. Epub 2018 Nov 22.

Department of Advanced Biomaterials, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.

Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of antiresorptive agents like bisphosphonates. Abnormal concentrations of various trace metallic elements contained in bone minerals have been associated with MRONJ. In this study, we focused on trace metallic elements contained in the MRONJ sequestrum; their content and distribution were compared to those in osteomyelitis and non-inflammatory bones using inductively coupled plasma atomic emission spectroscopy (ICP-AES) and synchrotron radiation X-ray fluorescence analysis (SR-XRF). Read More

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http://dx.doi.org/10.1007/s00774-018-0975-3DOI Listing
November 2018
6 Reads

Re-fracture and correlated risk factors in patients with osteoporotic vertebral fractures.

J Bone Miner Metab 2018 Nov 21. Epub 2018 Nov 21.

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.

Re-fracture risk is higher following osteoporotic fracture. However, there is no accurately reported rate of re-fracture incidence in southwest China. The purpose of this study was to describe the osteoporotic vertebral fracture (OVF) survival for re-fracture state and analyze the risk of re-fracture. Read More

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http://dx.doi.org/10.1007/s00774-018-0974-4DOI Listing
November 2018
7 Reads

Bone microstructure is significantly altered in CRPS-affected distal tibiae as detected by HR-pQCT: a retrospective cross-sectional study.

J Bone Miner Metab 2018 Nov 21. Epub 2018 Nov 21.

Department of Orthopaedic Surgery, University Medical Centre Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

In the course of complex regional pain syndrome (CRPS), local osteopenia in the subchondral/subcortical areas of the affected limb represents a central manifestation. Mechanistic aspects of CRPS-associated pathologies remain unclear, and knowledge about bone morphology in CRPS-affected areas is rare. The aim of this study was to assess trabecular and cortical bone microstructure in patients with CRPS of the distal tibiae. Read More

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http://dx.doi.org/10.1007/s00774-018-0976-2DOI Listing
November 2018
6 Reads

miR-195 contributes to human osteoarthritis via targeting PTHrP.

J Bone Miner Metab 2018 Nov 21. Epub 2018 Nov 21.

Department of Orthopedics, The Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, 382 Wuyi Road, Taiyuan, 030001, Shanxi, China.

The dysregulated expression of the osteoarthritis (OA)-related genes in cartilage, such as matrix metalloproteinase 13 (MMP-13) and type X collagen (Col X), facilitates the onset and progression of OA. Reduced parathyroid hormone-related protein (PTHrP) may also accelerate this progression. Furthermore, miRNAs, endogenous regulators of mRNAs, are thought to play key roles in the pathogenesis of OA. Read More

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http://dx.doi.org/10.1007/s00774-018-0973-5DOI Listing
November 2018
9 Reads

Screening of key candidate genes and pathways for osteocytes involved in the differential response to different types of mechanical stimulation using a bioinformatics analysis.

J Bone Miner Metab 2018 Nov 9. Epub 2018 Nov 9.

Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata, Kita-ku, Okayama, 700-8525, Japan.

This study aimed to predict the key genes and pathways that are activated when different types of mechanical loading are applied to osteocytes. mRNA expression datasets (series number of GSE62128 and GSE42874) were obtained from Gene Expression Omnibus database (GEO). High gravity-treated osteocytic MLO-Y4 cell-line samples from GSE62128 (Set1), and fluid flow-treated MLO-Y4 samples from GSE42874 (Set2) were employed. Read More

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http://link.springer.com/10.1007/s00774-018-0963-7
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http://dx.doi.org/10.1007/s00774-018-0963-7DOI Listing
November 2018
6 Reads

The effect of testosterone itself and in combination with letrozole on bone mineral density in male rats.

J Bone Miner Metab 2018 Nov 3. Epub 2018 Nov 3.

Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, P.O. Box: 71345-1744, Shiraz, Iran.

Testosterone is an essential hormone to maintain bone integrity; however, the effect of aromatase enzyme in androgen-induced bone maintenance remains somewhat unclear. The present study evaluated the effect of testosterone itself and combined with letrozole, an aromatase inhibitor, on bone mineral density of male rats. Total of 48 male rats were divided into 4 equal groups (n = 12/group); sham group, O: orchiectomy, O + T: orchiectomized rats treated with testosterone, O + T + L: orchiectomized rats treated with combination of testosterone and letrozole. Read More

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http://dx.doi.org/10.1007/s00774-018-0972-6DOI Listing
November 2018

Calcium restriction during lactation has minimal effects on post-weaning mineral metabolism and bone recovery.

J Bone Miner Metab 2018 Oct 25. Epub 2018 Oct 25.

Department of Cell and Molecular Medicine, Rush University Medical Center, Chicago, IL, USA.

Dietary calcium (Ca) restriction during lactation in the rat, which induces intra-cortical and endocortical remodeling, has been proposed as a model to study bone matrix maturation in the adult skeleton. The purpose of this study was to assess the effects of dietary Ca restriction during lactation on post-weaning mineral metabolism and bone formation. Mated female Sprague-Dawley rats were randomized into groups receiving either 0. Read More

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http://dx.doi.org/10.1007/s00774-018-0969-1DOI Listing
October 2018

Lycopene influences osteoblast functional activity and prevents femur bone loss in female rats submitted to an experimental model of osteoporosis.

J Bone Miner Metab 2018 Oct 24. Epub 2018 Oct 24.

Cell Culture Laboratory, Department of Morphology, Physiology and Basic Pathology, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n, Ribeirão Preto, SP, 14040-904, Brazil.

Antioxidant properties of several nutrients may influence bone metabolism, affording protection against damaging effects caused by oxidative stress. Thus, we hypothesized that lycopene may benefit bone tissue metabolism and functional activity of osteoblastic cells from bone marrow of osteoporotic female rats. Wistar rats were ovariectomized and paired with sham animals. Read More

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http://dx.doi.org/10.1007/s00774-018-0970-8DOI Listing
October 2018
3 Reads

Cortical bone mineral density is increased by the cathepsin K inhibitor ONO-5334, which leads to a robust increase in bone strength: results from a 16-month study in ovariectomised cynomolgus monkeys.

J Bone Miner Metab 2018 Oct 24. Epub 2018 Oct 24.

Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai Shimamoto-cho Mishima-gun, Osaka, 618-8585, Japan.

This study evaluated the long-term effects of the cathepsin K inhibitor ONO-5334 on bone mass and strength in ovariectomised (OVX) cynomolgus monkeys. Animals were assigned to one of the following six groups: Sham (non-OVX), OVX control treated with vehicle, ONO-5334 1.2, 6 or 30 mg/kg/day, p. Read More

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http://dx.doi.org/10.1007/s00774-018-0968-2DOI Listing
October 2018
8 Reads
2.460 Impact Factor

Regulatory mechanisms of sclerostin expression during bone remodeling.

J Bone Miner Metab 2018 Oct 24. Epub 2018 Oct 24.

Division of Hard Tissue Research, Institute for Oral Science, Matsumoto Dental University, 1780 Gobara, Hiro-oka, Shiojiri, Nagano, 399-0781, Japan.

Osteocytes are embedded in bone matrices and are connected to each other to respond to mechanical loading on bone. Recent studies have demonstrated the roles of mechanical loading in bone accrual. Bone responds to mechanical loading by decreasing the expression of sclerostin, an inhibitor of Wnt/β-catenin signals, in osteocytes. Read More

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http://link.springer.com/10.1007/s00774-018-0971-7
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http://dx.doi.org/10.1007/s00774-018-0971-7DOI Listing
October 2018
7 Reads

Insulin-like growth factor-I is required to maintain muscle volume in adult mice.

J Bone Miner Metab 2018 Oct 15. Epub 2018 Oct 15.

Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Insulin-like growth factor-I (IGF-I) is a peptide with diverse functions, among them regulation of embryonic development and bone homeostasis. Serum IGF-I levels decline in the elderly; however, IGF-I function in adults has not been clearly defined. Here, we show that IGF-I is required to maintain muscle mass in adults. Read More

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http://dx.doi.org/10.1007/s00774-018-0964-6DOI Listing
October 2018
2 Reads

Clinical immunity in bone and joints.

Authors:
Yoshiya Tanaka

J Bone Miner Metab 2018 Oct 15. Epub 2018 Oct 15.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Kitakyushu, 807-8555, Japan.

The immune system and bone metabolism influence each other. An imbalance in the immune system, resulting in inflammatory stimuli may induce an imbalance in bone turnover via induction of osteoclast differentiation and inhibition of osteoblast differentiation, leading to various pathological conditions including osteoporosis. T-cell subsets, helper T (Th)1 and Th17, which activate the immune system, induce osteoclasts, whereas regulatory T (Treg) cells, responsible for immunosuppression, inhibit osteoclastic differentiation. Read More

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http://link.springer.com/10.1007/s00774-018-0965-5
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http://dx.doi.org/10.1007/s00774-018-0965-5DOI Listing
October 2018
13 Reads

Lipid microenvironment affects the ability of proteoliposomes harboring TNAP to induce mineralization without nucleators.

J Bone Miner Metab 2018 Oct 15. Epub 2018 Oct 15.

Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto da Universidade de São Paulo (FFCLRP-USP), Av. Bandeirantes 3900, Ribeirão Preto, SP, 14040-901, Brazil.

Tissue-nonspecific alkaline phosphatase (TNAP), a glycosylphosphatidylinositol-anchored ectoenzyme present on the membrane of matrix vesicles (MVs), hydrolyzes the mineralization inhibitor inorganic pyrophosphate as well as ATP to generate the inorganic phosphate needed for apatite formation. Herein, we used proteoliposomes harboring TNAP as MV biomimetics with or without nucleators of mineral formation (amorphous calcium phosphate and complexes with phosphatidylserine) to assess the role of the MVs' membrane lipid composition on TNAP activity by means of turbidity assay and FTIR analysis. We found that TNAP-proteoliposomes have the ability to induce mineralization even in the absence of mineral nucleators. Read More

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http://link.springer.com/10.1007/s00774-018-0962-8
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http://dx.doi.org/10.1007/s00774-018-0962-8DOI Listing
October 2018
4 Reads

Journal of Bone and Mineral Metabolism Best Paper Award 2018.

Authors:

J Bone Miner Metab 2018 Nov;36(6):627

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http://dx.doi.org/10.1007/s00774-018-0966-4DOI Listing
November 2018

Congenital hypophosphataemia in adults: determinants of bone turnover markers and amelioration of renal phosphate wasting following total parathyroidectomy.

J Bone Miner Metab 2018 Sep 20. Epub 2018 Sep 20.

UCD School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.

Congenital hypophosphataemia (CH) is a collection of disorders that cause defective bone mineralisation manifesting with rickets in childhood and osteomalacia in adulthood. Bone turnover markers (BTMs) are surrogate measures of metabolic bone disease severity. We explored the utility of BTMs in 27 adults with CH: 23 had X-linked hypophosphataemia (XLH), of whom 2 were hypoparathyroid post-total parathyroidectomy (PTx); 2 had autosomal dominant hypophosphataemic rickets (ADHR), and 2 had none of the known mutations. Read More

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http://dx.doi.org/10.1007/s00774-018-0957-5DOI Listing
September 2018
2 Reads

Overweight and underweight are risk factors for vertebral fractures in patients with type 2 diabetes mellitus.

J Bone Miner Metab 2018 Sep 20. Epub 2018 Sep 20.

Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.

The aim of this cross-sectional study was to examine the association between body mass index (BMI) and the prevalence of vertebral fracture (VF) in Japanese patients with type 2 diabetes (T2DM). A total of 798 patients with T2DM were enrolled. VF was determined semi-quantitatively using lateral X-ray films. Read More

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http://dx.doi.org/10.1007/s00774-018-0960-xDOI Listing
September 2018
1 Read

Change of skeletal muscle mass in patients with pheochromocytoma.

J Bone Miner Metab 2018 Sep 20. Epub 2018 Sep 20.

Division of Endocrinology and Metabolism, Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.

The effects of catecholamine excess due to pheochromocytoma on body composition, including skeletal muscle mass, are unknown. Here, we investigated the effects of catecholamine metabolites on body composition in subjects with pheochromocytoma. After body compositions using bioelectrical impedance analysis, urinary metanephrine (UM), and urinary normetanephrine (UNM) were measured in 16 patients with pheochromocytoma and 224 patients with nonfunctioning adrenal incidentaloma (NFAI), we compared skeletal muscle mass and fat mass (FM) between the two groups. Read More

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http://link.springer.com/10.1007/s00774-018-0959-3
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http://dx.doi.org/10.1007/s00774-018-0959-3DOI Listing
September 2018
5 Reads

Effect of CBX7 deficiency on the socket healing after tooth extractions.

J Bone Miner Metab 2018 Sep 20. Epub 2018 Sep 20.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, No. 140, Hanzhong Road, Nanjing, 210029, People's Republic of China.

CBX7 is shown to down-regulate the expression of osteopontin (OPN) that is associated with osteoblast function. Here, we studied the role of CBX7 in the wound healing of tooth extraction socket in which osteoblast activity is critical via comparison between CBX7-knockout (CBX7) mice and their wild-type (WT) counterparts of 6 weeks old with maxillary first molar extracted. Mice were euthanized at 7, 14, and 21 days after extractions, and alveolar sockets were assessed by semi-quantitative histomorphometry for hard tissue healing, including new bone fill (Masson's trichrome staining), osteoblast activity (OPN/osterix, Osx), osteoclast activity (tartrate-resistant acid phosphatase, TRAP), and for soft tissue healing, including blood vessels (alpha smooth muscle actin, α-SMA). Read More

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http://link.springer.com/10.1007/s00774-018-0958-4
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http://dx.doi.org/10.1007/s00774-018-0958-4DOI Listing
September 2018
17 Reads

Assessment of patient-reported outcomes (PROs): treatment satisfaction, medication adherence, and quality of life (QoL) and the associated factors in postmenopausal osteoporosis (PMO) patients in Korea.

J Bone Miner Metab 2018 Sep 20. Epub 2018 Sep 20.

Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Patient-reported outcomes (PROs) provide practical guides for treatment; however, studies that have evaluated PROs of women in Korea with postmenopausal osteoporosis (PMO) are lacking. This cross-sectional, multi-center (29 nationwide hospitals) study, performed from March 2013 to July 2014, aimed to assess PROs related to treatment satisfaction, medication adherence, and quality of life (QoL) in Korean PMO women using osteoporosis medication for prevention/treatment. Patient demographics, clinical characteristics, treatment patterns, PROs, and experience using medication were collected. Read More

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http://link.springer.com/10.1007/s00774-018-0956-6
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http://dx.doi.org/10.1007/s00774-018-0956-6DOI Listing
September 2018
14 Reads

The relationships between bone variables and physical fitness across the BMI spectrum in young adult women.

J Bone Miner Metab 2018 Sep 6. Epub 2018 Sep 6.

Department of Physical Education, Faculty of Arts and Social Sciences, University of Balamand, El-Koura, Lebanon.

In this cross-sectional study we aimed to evaluate the relationship between physical fitness and bone variables across the body mass index (BMI) spectrum in women aged 20-35 years. The study included 13 underweight women (BMI < 18.5 kg/m), 24 normal weight women (BMI 18. Read More

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http://link.springer.com/10.1007/s00774-018-0949-5
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http://dx.doi.org/10.1007/s00774-018-0949-5DOI Listing
September 2018
8 Reads
2.460 Impact Factor

Bone mineral density loss in ambulatory children with epilepsy in spite of using supplemental vitamin D in Southern Iran: a case-control study.

J Bone Miner Metab 2018 Sep 6. Epub 2018 Sep 6.

Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Epilepsy might have adverse effect on bone density due to underlying disease, drugs, vitamin D deficiency, immobilization and malnutrition. We investigated the bone mineral density in ambulatory vitamin-D supplemented children with epilepsy. This case-control study was conducted on 90 epileptic children aged 11. Read More

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http://dx.doi.org/10.1007/s00774-018-0951-yDOI Listing
September 2018

Osteoporosis and vertebral fracture are associated with deterioration of activities of daily living and quality of life in patients with type 2 diabetes mellitus.

J Bone Miner Metab 2018 Sep 6. Epub 2018 Sep 6.

Department of Internal Medicine 1, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, 693-8501, Japan.

Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fracture. However, whether diabetes-related osteoporosis independently contributes to the deterioration of activities of daily living (ADLs) and quality of life (QOL) is unclear. This cross-sectional study investigated the association between osteoporosis, ADLs, and QOL in 309 patients with T2DM. Read More

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http://dx.doi.org/10.1007/s00774-018-0948-6DOI Listing
September 2018
15 Reads

Umbilical cord mesenchymal stem cell conditioned medium restored the expression of collagen II and aggrecan in nucleus pulposus mesenchymal stem cells exposed to high glucose.

J Bone Miner Metab 2018 Sep 5. Epub 2018 Sep 5.

Cryomedicine Laboratory, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, People's Republic of China.

Diabetes can cause intervertebral disc degeneration by accelerating apoptosis and senescence of nucleus pulposus mesenchymal stem cells (NPMSCs). The aim of this study was to determine the effect of umbilical cord mesenchymal stem cells (UCMSCs) conditioned medium on high glucose (HG) induced degradation of NPMSCs produced extracellular matrix. NPMSCs were isolated from the inner intervertebral disc tissue using type XI collagenase digestion. Read More

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http://dx.doi.org/10.1007/s00774-018-0953-9DOI Listing
September 2018

FGF2-responsive genes in human dental pulp cells assessed using a rat spinal cord injury model.

J Bone Miner Metab 2018 Sep 5. Epub 2018 Sep 5.

Department of Tissue and Organ Development, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.

The central nervous system in adult mammals does not heal spontaneously after spinal cord injury (SCI). However, SCI treatment has been improved recently following the development of cell transplantation therapy. We recently reported that fibroblast growth factor (FGF) 2-pretreated human dental pulp cells (hDPCs) can improve recovery in a rat model of SCI. Read More

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http://link.springer.com/10.1007/s00774-018-0954-8
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http://dx.doi.org/10.1007/s00774-018-0954-8DOI Listing
September 2018
17 Reads

Development of scoliosis in young children with osteogenesis imperfecta undergoing intravenous bisphosphonate therapy.

J Bone Miner Metab 2018 Sep 5. Epub 2018 Sep 5.

Department of Orthopedic Surgery, Faculty of Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

The purpose of this study was to clarify the prevalence of scoliosis and determine risk factors for the development of scoliosis in young children with osteogenesis imperfecta (OI) who underwent intravenous pamidronate (PAM) therapy. Thirty-four young children with OI who had no scoliosis at the first PAM administration underwent cyclic PAM therapy alone. The medical records and radiographs of these patients were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00774-018-0952-xDOI Listing
September 2018
2 Reads

Bone marrow lesion is associated with disability for activities of daily living in patients with early stage knee osteoarthritis.

J Bone Miner Metab 2018 Sep 5. Epub 2018 Sep 5.

Department of Medicine for Orthtopaedics and Motor Organ, Juntendo University Graduate School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo, 113-8421, Japan.

Osteoarthritis of the knee (knee OA) induces pain, loss of mobility and diminished activities of daily living (ADL). Although an understanding of the pathophysiology of early stage knee OA has been developed, the structural changes associated with disability for ADL in early stage knee OA are still unclear. The aim of the present study was to examine magnetic resonance imaging (MRI)-detected changes associated with disability for ADL in patients with early stage knee OA. Read More

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http://dx.doi.org/10.1007/s00774-018-0950-zDOI Listing
September 2018
7 Reads

Denosumab is effective toward glucocorticoid-induced osteoporosis patients complicated with rheumatic diseases regardless of prior anti-osteoporotic drugs.

J Bone Miner Metab 2018 Sep 5. Epub 2018 Sep 5.

Division of Advanced Preventive Medical Sciences, Unit of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

We examined the efficacy and safety of denosumab as treatment for glucocorticoid-induced osteoporosis (GIOP) patients complicated with rheumatic diseases, by measuring patients' lumber bone mineral density (BMD) and bone turnover markers. A total of 66 consecutive patients for whom denosumab was initiated between July 2013 and August 2016 were enrolled and evaluated for 12 months. All of the patients were treated with glucocorticoids for underlying rheumatic diseases. Read More

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http://dx.doi.org/10.1007/s00774-018-0955-7DOI Listing
September 2018
3 Reads

Effect of a 6-week supervised detraining period on bone metabolism markers and their association with ergometrics and components of the hypothalamic-pituitary-gonadal (HPG) axis in professional male soccer players.

J Bone Miner Metab 2018 Sep 5. Epub 2018 Sep 5.

Lab of Clinical Chemistry-Biochemistry, Department of Laboratory Medicine, School of Medicine, University of Crete, Heraklion, Crete, Greece.

The aim of this study was to examine the effect of a supervised 6-week detraining period on bone metabolism markers, and their association with ergometrics, and components of the hypothalamic-pituitary-gonadal (HPG) axis in elite male professional soccer players. Sixty-seven soccer players (mean age ± SD 23.4 ± 5. Read More

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http://dx.doi.org/10.1007/s00774-018-0947-7DOI Listing
September 2018
13 Reads

1,25-Dihydroxyvitamin D3 attenuates disease severity and induces synoviocyte apoptosis in a concentration-dependent manner in rats with adjuvant-induced arthritis by inactivating the NF-κB signaling pathway.

J Bone Miner Metab 2018 Aug 10. Epub 2018 Aug 10.

Department of Bone and Joint Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, People's Republic of China.

An aggressive proliferation of synoviocytes is the hallmark of rheumatoid arthritis (RA). Emerging evidence shows that inhibiting the NF-κB signaling pathway with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] may be a therapeutic approach for controlling inflammatory diseases. In this study, we demonstrated the protective effects of three different 1,25(OH)2D3 concentration on adjuvant-induced arthritis (AA) rats through the NF-κB signaling pathway and their pro-apoptotic roles in cultured adjuvant-induced arthritis synoviocytes (AIASs). Read More

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http://dx.doi.org/10.1007/s00774-018-0944-xDOI Listing
August 2018
2 Reads

PEG10 counteracts signaling pathways of TGF-β and BMP to regulate growth, motility and invasion of SW1353 chondrosarcoma cells.

J Bone Miner Metab 2018 Aug 9. Epub 2018 Aug 9.

Department of Medical Joint Materials, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima, 890-8544, Japan.

Recently, we reported highly active transforming growth factor (TGF)-β and bone morphogenetic protein (BMP) signaling in human chondrosarcoma samples and concurrent downregulation of paternally expressed gene 10 (PEG10). PEG10 expression was suppressed by TGF-β signaling, and PEG10 interfered with the TGF-β and BMP-SMAD pathways in chondrosarcoma cells. However, the roles of PEG10 in bone tumors, including chondrosarcoma, remain unknown. Read More

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http://dx.doi.org/10.1007/s00774-018-0946-8DOI Listing
August 2018
5 Reads

Microcrack-associated bone remodeling is rarely observed in biopsies from athletes with medial tibial stress syndrome.

J Bone Miner Metab 2018 Jul 31. Epub 2018 Jul 31.

Bergman Clinics, Naarden, The Netherlands.

The pathology of medial tibial stress syndrome (MTSS) is unknown. Studies suggest that MTSS is a bony overload injury, but histological evidence is sparse. The presence of microdamage, and its potential association with targeted remodeling, could provide evidence for the pathogenesis of MTSS. Read More

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http://dx.doi.org/10.1007/s00774-018-0945-9DOI Listing
July 2018
2 Reads

Finite-element analysis of the mouse proximal ulna in response to elbow loading.

J Bone Miner Metab 2018 Jul 30. Epub 2018 Jul 30.

Department of Mechanical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202, USA.

Bone is a mechano-sensitive tissue that alters its structure and properties in response to mechanical loading. We have previously shown that application of lateral dynamic loads to a synovial joint, such as the knee and elbow, suppresses degradation of cartilage and prevents bone loss in arthritis and postmenopausal mouse models, respectively. While loading effects on pathophysiology have been reported, mechanical effects on the loaded joint are not fully understood. Read More

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http://dx.doi.org/10.1007/s00774-018-0943-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353704PMC
July 2018
1 Read

Metformin protects bone mass in ultra-high-molecular-weight polyethylene particle-induced osteolysis by regulating osteocyte secretion.

J Bone Miner Metab 2018 Jul 21. Epub 2018 Jul 21.

Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.

Metformin, an anti-hyperglycemic agent used for type 2 diabetes, has recently been found to have more effects apart from glucose regulation. We found that, in ultra-high-molecular-weight polyethylene particle-induced osteolysis mouse models, metformin had bone protect property and reduced the negative regulator of bone formation sclerostin (SOST) and Dickkopf-related protein 1 (DKK1), and increased osteoprotegerin (OPG) secretion and the ratio of OPG/Receptor Activator for Nuclear Factor-κB Ligand (RANKL). In vitro, we established a 3D co-culture system in which metformin affects osteoblasts and osteoclasts through mature osteocytes secretion. Read More

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http://dx.doi.org/10.1007/s00774-018-0939-7DOI Listing
July 2018
2 Reads

Study design of multi-center, open-label randomized controlled, head-to-head trial comparing minodronic acid and raloxifene: Japanese Osteoporosis Intervention Trial (JOINT)-04.

J Bone Miner Metab 2018 Jul 17. Epub 2018 Jul 17.

Department of Internal Medicine, Research Institute and Practice for Involutional Diseases, Nagano, Japan.

We planned to conduct multi-center, open-labeled, blinded-endpoints, head-to-head randomized trial of minodronate and raloxifene to compare incidences of vertebral and non-vertebral fractures. The study is the Japanese Osteoporosis Intervention Trial protocol number 4 (JOINT-4). Here, we present the pre-fixed study design. Read More

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http://dx.doi.org/10.1007/s00774-018-0942-zDOI Listing
July 2018
8 Reads