6,178 results match your criteria Journal of Biomedical Optics [Journal]


Design, fabrication, and feasibility analysis of a colorimetric detection system with a smartphone for self-monitoring blood glucose.

J Biomed Opt 2019 Feb;24(2):1-7

iXensor Co. Ltd., Taipei, Taiwan.

Maintaining appropriate insulin levels is very important for diabetes patients. Effective monitoring of blood glucose can aid in maintaining the body's insulin level, and thus reduce disease severities, secondary complications, and related mortalities. However, existing blood glucose measurement devices are inconvenient to carry and involve complex procedures, reducing the willingness of diabetes patients to regularly measure blood glucose. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.027002DOI Listing
February 2019

Development of an integrated multimodal optical imaging system with real-time image analysis for the evaluation of oral premalignant lesions.

J Biomed Opt 2019 Feb;24(2):1-10

Rice University, Department of Bioengineering, Houston, Texas, United States.

Oral premalignant lesions (OPLs), such as leukoplakia, are at risk of malignant transformation to oral cancer. Clinicians can elect to biopsy OPLs and assess them for dysplasia, a marker of increased risk. However, it is challenging to decide which OPLs need a biopsy and to select a biopsy site. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.025003DOI Listing
February 2019

Dual-grid mesh-based Monte Carlo algorithm for efficient photon transport simulations in complex three-dimensional media.

J Biomed Opt 2019 Feb;24(2):1-4

Northeastern Univ., United States.

The mesh-based Monte Carlo (MMC) method is an efficient algorithm to model light propagation inside tissues with complex boundaries, but choosing appropriate mesh density can be challenging. A fine mesh improves the spatial resolution of the output but requires more computation. We propose an improved MMC-dual-grid mesh-based Monte Carlo (DMMC)-to accelerate photon simulations using a coarsely tessellated tetrahedral mesh for ray-tracing computation and an independent voxelated grid for output data storage. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.020503DOI Listing
February 2019

Photoacoustic computed tomography of human extremities.

J Biomed Opt 2019 Feb;24(2):1-8

California Institute of Technology, Caltech Optical Imaging Laboratory, Department of Electrical Eng, United States.

We present a method of imaging angiographic structures in human extremities, including hands, arms, legs, and feet, using a newly developed photoacoustic computed tomography (PACT) system. The system features deep penetration (1.8 cm in muscular tissues) with high spatial and temporal resolutions. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.026003DOI Listing
February 2019
1 Read

Special Section Guest Editorial: Translational Biophotonics.

J Biomed Opt 2019 Feb;24(2):1-2

Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, University of California.

This guest editorial introduces the special section on Translational Biophotonics. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.021200DOI Listing
February 2019

Micron resolution, high-fidelity three-dimensional vascular optical imaging phantoms.

J Biomed Opt 2019 Feb;24(2):1-4

Wellcome Trust-EPSRC Centre for Interventional and Surgical Sciences, London, United Kingdom.

Microscopic and mesoscale optical imaging techniques allow for three-dimensional (3-D) imaging of biological tissue across millimeter-scale regions, and imaging phantom models are invaluable for system characterization and clinical training. Phantom models that replicate complex 3-D geometries with both structural and molecular contrast, with resolution and lateral dimensions equivalent to those of imaging techniques (<20  μm), have proven elusive. We present a method for fabricating phantom models using a combination of two-photon polymerization (2PP) to print scaffolds, and microinjection of tailored tissue-mimicking materials to simulate healthy and diseased tissue. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.020502DOI Listing
February 2019

Dynamic light scattering optical coherence tomography to probe motion of subcellular scatterers.

J Biomed Opt 2019 Feb;24(2):1-7

Ryerson University, Department of Physics, Faculty of Science, Toronto, Canada.

Optical coherence tomography (OCT) is used to provide anatomical information of biological systems but can also provide functional information by characterizing the motion of intracellular structures. Dynamic light scattering OCT was performed on intact, control MCF-7 breast cancer cells and cells either treated with paclitaxel to induce apoptosis or deprived of nutrients to induce oncosis. Autocorrelations (ACs) of the temporal fluctuations of OCT intensity signals demonstrate a significant decrease in decorrelation time after 24 h in both the paclitaxel-treated and nutrient-deprived cell groups but no significant differences between the two groups. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.025002DOI Listing
February 2019
1 Read

Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures.

J Biomed Opt 2019 Feb;24(2):1-10

Polytechnique Montreal, Montreal, Canada.

Surgical excision of the whole prostate through a radical prostatectomy procedure is part of the standard of care for prostate cancer. Positive surgical margins (cancer cells having spread into surrounding nonresected tissue) occur in as many as 1 in 5 cases and strongly correlate with disease recurrence and the requirement of adjuvant treatment. Margin assessment is currently only performed by pathologists hours to days following surgery and the integration of a real-time surgical readout would benefit current prostatectomy procedures. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.025001DOI Listing
February 2019

Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages (Erratum).

J Biomed Opt 2019 Feb;24(2)

Mass General Research Institute, Boston, Massachusetts, United States.

This erratum corrects an error in "Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages," by Z. Li et al. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.029802DOI Listing
February 2019

Special Section Guest Editorial: Biomedical Imaging and Sensing.

J Biomed Opt 2019 Feb;24(3)

National Taiwan University, Taiwan.

This guest editorial introduces the special section on Biomedical Imaging and Sensing. Read More

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http://dx.doi.org/10.1117/1.JBO.24.3.031001DOI Listing
February 2019

Microscopy with ultraviolet surface excitation for wide-area pathology of breast surgical margins.

J Biomed Opt 2019 Feb;24(2):1-11

University of Washington, Department of Mechanical Engineering, Seattle, Washington, United States.

Intraoperative assessment of breast surgical margins will be of value for reducing the rate of re-excision surgeries for lumpectomy patients. While frozen-section histology is used for intraoperative guidance of certain cancers, it provides limited sampling of the margin surface (typically <1  %   of the margin) and is inferior to gold-standard histology, especially for fatty tissues that do not freeze well, such as breast specimens. Microscopy with ultraviolet surface excitation (MUSE) is a nondestructive superficial optical-sectioning technique that has the potential to enable rapid, high-resolution examination of excised margin surfaces. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.026501DOI Listing
February 2019
2 Reads

Diagnostic performance of receptor-specific surgical specimen staining correlates with receptor expression level.

J Biomed Opt 2019 Feb;24(2):1-9

Oregon Health and Science University, Department of Biomedical Engineering, Portland, Oregon, United States.

Intraoperative margin assessment is imperative to cancer cure but is a continued challenge to successful surgery. Breast conserving surgery is a relevant example, where a cosmetically improved outcome is gained over mastectomy, but re-excision is required in >25  %   of cases due to positive or closely involved margins. Clinical translation of margin assessment modalities that must directly contact the patient or required administered contrast agents are time consuming and costly to move from bench to bedside. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.026002DOI Listing
February 2019

fNIRS improves seizure detection in multimodal EEG-fNIRS recordings.

J Biomed Opt 2019 Feb;24(5):1-9

Université de Montréal, École Polytechnique de Montréal, Montréal, Québec, Canada.

In the context of epilepsy monitoring, electroencephalography (EEG) remains the modality of choice. Functional near-infrared spectroscopy (fNIRS) is a relatively innovative modality that cannot only characterize hemodynamic profiles of seizures but also allow for long-term recordings. We employ deep learning methods to investigate the benefits of integrating fNIRS measures for seizure detection. Read More

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https://www.spiedigitallibrary.org/journals/journal-of-biome
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http://dx.doi.org/10.1117/1.JBO.24.5.051408DOI Listing
February 2019
2 Reads

Terahertz spectroscopy of gelatin-embedded human brain gliomas of different grades: a road toward intraoperative THz diagnosis.

J Biomed Opt 2019 Feb;24(2):1-5

Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia.

We applied terahertz (THz)-pulsed spectroscopy to study ex vivo the refractive index and absorption coefficient of human brain gliomas featuring different grades, as well as perifocal regions containing both intact and edematous tissues. Glioma samples from 26 patients were considered and analyzed according to further histological examination. In order to fix tissues for the THz measurements, we applied gelatin embedding, which allows for sustaining their THz response unaltered, as compared to that of the freshly excised tissues. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.027001DOI Listing
February 2019
2 Reads

Cherenkov luminescence imaging of shallow sources in semitransparent media.

J Biomed Opt 2019 Feb;24(2):1-9

Washington University in St. Louis, Department of Radiology, St. Louis, Missouri, United States.

We experimentally investigated the Cherenkov luminescence imaging (CLI) of the isotopes with different beta particles energies (Cu64, F18, Au198, P32, and Br76) in semitransparent biological equivalent media. The main focus of this work is to characterize the CLI when the sources are at the depth comparable with the range of beta particles. The experimental results were compared with Monte Carlo (MC) simulation results to fine tune the simulation parameters to better model the phantom materials. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.026001DOI Listing
February 2019

Impact of hemoglobin breakdown products in the spectral analysis of burn wounds using spatial frequency domain spectroscopy.

J Biomed Opt 2019 Feb;24(2):1-4

University of California Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.

Burn wounds and wound healing invoke several biological processes that may complicate the interpretation of spectral imaging data. Through analysis of spatial frequency domain spectroscopy data (450 to 1000 nm) obtained from longitudinal investigations using a graded porcine burn wound healing model, we have identified features in the absorption spectrum that appear to suggest the presence of hemoglobin breakdown products, e.g. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.020501DOI Listing
February 2019

Early diagnosis of traumatic intracranial hematomas.

J Biomed Opt 2019 Feb;24(5):1-10

Infrascan Inc., Philadelphia, Pennsylvania, United States.

Timing of the intervention for intracranial hematomas is critical for its success, specifically since expansion of the hemorrhage can result in debilitating and sometimes fatal outcomes. Led by Britton Chance, we and an extended team from University of Pennsylvania, Baylor and Drexel universities developed a handheld brain hematoma detector for early triage and diagnosis of head trauma victims. After obtaining de novo Food and Drug Administration clearance, over 200 systems are deployed in all Marine battalion aid stations around the world. Read More

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http://dx.doi.org/10.1117/1.JBO.24.5.051411DOI Listing
February 2019
4 Reads

Hyperspectral imaging for tissue classification, a way toward smart laparoscopic colorectal surgery.

J Biomed Opt 2019 Jan;24(1):1-9

Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Department of Surgery, Amsterdam, The Netherlands.

In the last decades, laparoscopic surgery has become the gold standard in patients with colorectal cancer. To overcome the drawback of reduced tactile feedback, real-time tissue classification could be of great benefit. In this ex vivo study, hyperspectral imaging (HSI) was used to distinguish tumor tissue from healthy surrounding tissue. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.016002DOI Listing
January 2019
1 Read

Redox imaging and optical coherence tomography of the respiratory ciliated epithelium.

J Biomed Opt 2019 Jan;24(1):1-4

University of Wisconsin-Madison, Department of Biomedical Engineering, Madison, Wisconsin, United States.

Optical coherence tomography (OCT) is an emerging technology for in vivo airway and lung imaging. However, OCT lacks sensitivity to the metabolic changes caused by inflammation, which drives chronic respiratory diseases such as asthma and chronic obstructive pulmonary disorder. Redox imaging (RI) is a label-free technique that uses the autofluorescence of the metabolic coenzymes NAD(P)H and flavin adenine dinucleotide (FAD) to probe cellular metabolism and could provide complimentary information to OCT for airway and lung imaging. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.010501DOI Listing
January 2019
3 Reads

Automated phase unwrapping in Doppler optical coherence tomography.

J Biomed Opt 2019 Jan;24(1):1-4

Oregon Health and Science University, Casey Eye Institute, Portland, Oregon, United States.

Phase wrapping is a crucial issue in Doppler optical coherence tomography (OCT) and restricts its automatic implementation for clinical applications that quantify total retinal blood flow. We propose an automated phase-unwrapping technique that takes advantage of the parabolic profile of blood flow velocity in vessels. Instead of inspecting the phase shift manually, the algorithm calculates the gradient magnitude of the phase shift on the cross-sectional image and automatically detects the presence of phase wrapping. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.010502DOI Listing
January 2019

Multiscale imaging of colitis in mice using confocal laser endomicroscopy, light-sheet fluorescence microscopy, and magnetic resonance imaging.

J Biomed Opt 2019 Jan;24(1):1-8

Chinese Academy of Sciences, Institute of Automation, CAS Key Laboratory of Molecular Imaging, Beiji, China.

The objective of our study is to develop a multimodality approach by combining magnetic resonance imaging (MRI) and optical imaging methods to assess acute murine colitis at the macro- and microscopic level. In vivo MRI is used to measure the cross-sectional areas of colons at the macroscopic level. Dual-color confocal laser endomicroscopy (CLE) allows in vivo examination of the fluorescently labeled epithelial cells and microvessels in the mucosa with a spatial resolution of ∼1. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.016003DOI Listing
January 2019
1 Read

Diffuse reflectance spectroscopy, a potential optical sensing technology for the detection of cortical breaches during spinal screw placement.

J Biomed Opt 2019 Jan;24(1):1-11

Delft University of Technology, Department of Biomechanical Engineering, Delft, Netherlands.

Safe and accurate placement of screws remains a critical issue in open and minimally invasive spine surgery. We propose to use diffuse reflectance (DR) spectroscopy as a sensing technology at the tip of a surgical instrument to ensure a safe path of the instrument through the cancellous bone of the vertebrae. This approach could potentially reduce the rate of cortical bone breaches, thereby resulting in fewer neural and vascular injuries during spinal fusion surgery. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.017002DOI Listing
January 2019
1 Read

Fast and precise image generation of blood vessels embedded in skin.

J Biomed Opt 2019 Jan;24(1):1-9

Institute for Laser Technologies in Medicine and Metrology, Ulm, Germany.

A software for fast rendering the visual appearance of a blood vessel located in human skin was developed based on a numerical solution of the radiative transfer equation. The user can specify geometrical properties, such as the depth and the diameter of the vessel, and physiological properties, such as the oxygen saturation of the vessel or the blood concentration in the skin. From these data, the spatially and spectrally resolved reflectance from the skin containing the blood vessel is calculated via Monte Carlo simulations, by which a two-dimensional image is generated. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.015002DOI Listing
January 2019

Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.

J Biomed Opt 2019 Jan;24(5):1-11

University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.

Diffuse optical tomography has demonstrated significant potential for clinical utility in the diagnosis and prognosis of breast cancer, and its use in combination with other structural imaging modalities improves lesion localization and the quantification of functional tissue properties. Here, we introduce a hybrid diffuse optical imaging system that operates concurrently with magnetic resonance imaging (MRI) in the imaging suite, utilizing commercially available MR surface coils. The instrument acquires both continuous-wave and time-domain diffuse optical data in the parallel-plate geometry, permitting both absolute assignment of tissue optical properties and three-dimensional tomography; moreover, the instrument is designed to incorporate diffuse correlation spectroscopic measurements for probing tissue blood flow. Read More

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http://dx.doi.org/10.1117/1.JBO.24.5.051409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345326PMC
January 2019

Machine learning in multiexposure laser speckle contrast imaging can replace conventional laser Doppler flowmetry.

J Biomed Opt 2019 Jan;24(1):1-11

Linköping University, Department of Biomedical Engineering, Linköping, Sweden.

Laser speckle contrast imaging (LSCI) enables video rate imaging of blood flow. However, its relation to tissue blood perfusion is nonlinear and depends strongly on exposure time. By contrast, the perfusion estimate from the slower laser Doppler flowmetry (LDF) technique has a relationship to blood perfusion that is better understood. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.016001DOI Listing
January 2019

Tissue spatial correlation as cancer marker.

J Biomed Opt 2019 Jan;24(1):1-6

University of Illinois at Urbana-Champaign, Beckman Institute of Advanced Science and Technology, De, United States.

We propose an intrinsic cancer marker in fixed tissue biopsy slides, which is based on the local spatial autocorrelation length obtained from quantitative phase images. The spatial autocorrelation length in a small region of the tissue phase image is sensitive to the nanoscale cellular morphological alterations and can hence inform on carcinogenesis. Therefore, this metric can potentially be used as an intrinsic cancer marker in histopathology. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.016502DOI Listing
January 2019

Vibration analysis of healthy skin: toward a noninvasive skin diagnosis methodology.

J Biomed Opt 2019 Jan;24(1):1-11

Wayne State University, OPIRA Laboratory, Biomedical Engineering Department, Detroit, Michigan, United States.

Several noninvasive imaging techniques have been developed to monitor the health of skin and enhance the diagnosis of skin diseases. Among them, skin elastography is a popular technique used to measure the elasticity of the skin. A change in the elasticity of the skin can influence its natural frequencies and mode shapes. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.015001DOI Listing
January 2019
5 Reads

Quantitative in situ time-series evaluation of osteoblastic collagen synthesis under cyclic strain using second-harmonic-generation microscopy.

J Biomed Opt 2019 Jan;24(3):1-8

Tokushima University, Graduate School of Technology, Industrial and Social Sciences, Tokushima City,, Japan.

The aim of this study is to evaluate the osteoblastic collagen synthesis under mechanical stimulation using second-harmonic-generation (SHG) microscopy. We apply SHG microscopy to monitor the collagen fibers synthesized by osteoblast-like cells (MC3T3-E1) without the need for fixation and staining. To quantitatively evaluate the influence of mechanical stimulation on osteoblastic collagen synthesis, we compare SHG images of osteoblast-synthesized collagen fibers with and without a cyclic stretch stimulus applied using a lab-made stretching device. Read More

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http://dx.doi.org/10.1117/1.JBO.24.3.031019DOI Listing
January 2019
1 Read

Noninvasive evaluation of hemodynamics and light scattering property during two-stage mouse cutaneous carcinogenesis based on multispectral diffuse reflectance images at isosbestic wavelengths of hemoglobin.

J Biomed Opt 2019 Jan;24(3):1-11

Tokyo University of Agriculture and Technology, Graduate School of Bio-Applications and Systems Engi, Japan.

We investigate a multispectral imaging method to evaluate spatiotemporal changes in both cutaneous hemoglobin concentration and light scattering parameter in mouse skin through diffuse reflectance spectroscopy using the reflectance images acquired at isosbestic wavelengths of hemoglobin (420, 450, 500, and 585 nm). In the proposed approach, Monte Carlo simulation-based empirical formulas are introduced to extract the scattering power b representing the wavelength dependence of light scattering spectrum of skin tissue, as well as the total hemoglobin concentration Cth in dermal vasculatures. The use of isosbestic wavelengths of hemoglobin enables the values of Cth and b to be estimated independently of the oxygenation of hemoglobin. Read More

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http://dx.doi.org/10.1117/1.JBO.24.3.031020DOI Listing
January 2019
4 Reads

Ensuring Scientific Publishing Credibility in Translational Biomedical Optics.

Authors:
Brian W Pogue

J Biomed Opt 2019 Jan;24(1):1-3

Editor-in-Chief Brian Pogue writes about publishing credibility in the field of translational biomedical optics. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.010101DOI Listing
January 2019
2 Reads

Optical pH measurement system using a single fluorescent dye for assessing susceptibility to dental caries.

J Biomed Opt 2019 Jan;24(1):1-8

University of Washington, Electrical and Computer Engineering, Seattle, Washington, United States.

Sugar-rich diets and poor dental hygiene promote the formation of a biofilm (plaque) that strongly adheres to the dental enamel surface and fosters the evolution of aciduric bacteria. The acid contributes to demineralization of the exterior tooth enamel, which accelerates after the pH drops below a critical value (∼5.5) for extended time periods resulting in the need for restorative procedures. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.017001DOI Listing
January 2019

Multicolor fluorescence microscopy using static light sheets and a single-channel detection.

J Biomed Opt 2019 Jan;24(1):1-8

Centro de Investigación Científica y de Educación Superior de Ensenada, Department of Optics, Ensena, Mexico.

We present a multicolor fluorescence microscope system, under a selective plane illumination microscopy (SPIM) configuration, using three continuous wave-lasers and a single-channel-detection camera. The laser intensities are modulated with three time-delayed pulse trains that operate synchronously at one third of the camera frame rate, allowing a sequential excitation and an image acquisition of up to three different biomarkers. The feasibility of this imaging acquisition mode is demonstrated by acquiring single-plane multicolor images of living hyphae of Neurospora crassa. Read More

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http://dx.doi.org/10.1117/1.JBO.24.1.016501DOI Listing
January 2019

Identifying molecular contributors to autofluorescence of neoplastic and normal colon sections using excitation-scanning hyperspectral imaging.

J Biomed Opt 2018 Dec;24(2):1-11

University of South Alabama, Department of Chemical and Biomolecular Engineering, Mobile, Alabama, United States.

Autofluorescence, the endogenous fluorescence present in cells and tissues, has historically been considered a nuisance in biomedical imaging. Many endogenous fluorophores, specifically, collagen, elastin, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide (FAD), are found throughout the human body. In fluorescence imaging scenarios, these signals can be prohibitive as they can outcompete signals introduced for diagnostic purposes. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.021207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307688PMC
December 2018

Sensing, monitoring, and release of therapeutics: the translational journey of next generation bandages.

J Biomed Opt 2018 Dec;24(2):1-9

Massachusetts General Hospital Research Institute, United States.

This article aims to be a progress report on the Sensing, Monitoring And Release of Therapeutics (SMART) bandage-one of the three technologies that received the inaugural SPIE Photonics West Translational Research Symposium Award in 2015. Invented and developed by Dr. Conor L. Read More

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http://dx.doi.org/10.1117/1.JBO.24.2.021201DOI Listing
December 2018
1 Read

Label-free real-time optical monitoring of DNA hybridization using SiN Mach-Zehnder interferometer-based integrated biosensing platform.

J Biomed Opt 2018 Dec;23(12):1-7

Ghent University/Imec, Photonics Research Group, Ghent, Belgium.

We report on the label-free real-time optical monitoring of DNA hybridization upon exposure to a flow of complementary DNA at different concentrations. The biosensor is composed of a silicon nitride integrated unbalanced Mach-Zehnder interferometer (MZI), with an integrated arrayed waveguide grating as a spectral filter. This MZI has been shown to have both sufficient multiplexing capability and limit of detection on the order of 10  -  6 RIU. Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.127002DOI Listing
December 2018

Detection of glycosaminoglycan loss in articular cartilage by fluorescence lifetime imaging.

J Biomed Opt 2018 Dec;23(12):1-8

University of California, Department of Biomedical Engineering, Davis, California, United States.

Glycosaminoglycan (GAG) loss is an early marker of osteoarthritis, which is a clinical late stage disease that affects millions of people worldwide. The goal of our study was to evaluate the ability of a fiber-based fluorescence lifetime imaging (FLIm) technique to detect GAG loss in articular cartilage. Native bovine cartilage explants (n  =  20) were exposed to 0 (control), 0. Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.126002DOI Listing
December 2018
10 Reads

Estimation of free hemoglobin concentrations in blood bags by diffuse reflectance spectroscopy.

J Biomed Opt 2018 Dec;23(12):1-12

Bahcesehir University, Faculty of Engineering and Natural Sciences, Department of Biomedical Enginee, Turkey.

Free hemoglobin (FHB) concentration is considered a prospect quality indicator for erythrocyte suspensions (ES) under storage. Storage lesions alter the optical properties of ES and can be monitored by diffuse reflectance spectroscopy. Due to storage lesions, erythrocytes lyse and release hemoglobin into the extracellular medium. Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.127001DOI Listing
December 2018
3 Reads

Optimization of frequency-doubled Er-doped fiber laser for miniature multiphoton endoscopy.

J Biomed Opt 2018 Dec;23(12):1-12

University of British Columbia, Department of Electrical and Computer Engineering, Vancouver, Canada.

Frequency-doubled femtosecond Er-doped fiber laser is a low-cost and portable excitation source suitable for multiphoton endoscopy. The frequency-doubled wavelength at 780 nm is used to excite the intrinsic fluorescence signal. The frequency-doubling with a periodically poled MgO  :  LiNbO3 (PPLN) is integrated in the distal end of the imaging head to achieve fiber connection. Read More

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https://www.spiedigitallibrary.org/journals/journal-of-biome
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http://dx.doi.org/10.1117/1.JBO.23.12.126503DOI Listing
December 2018
4 Reads

Special Section Guest Editorial: Pioneer in Biomedical Optics: Introduction to the Special Section in Honor of Steven L. Jacques.

J Biomed Opt 2018 Dec;23(12):1-3

California Institute of Technology, Cherng Department of Medical Engineering, Pasadena, California 9.

This guest editorial introduces the special section honoring Prof. Steven L. Jacques. Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.121601DOI Listing
December 2018
1 Read
2.859 Impact Factor

Supercontinuum-based nondisruptive scattering analyses of mouse fibroblast L929 cells before and after necrosis.

J Biomed Opt 2018 Dec;23(12):1-5

Fraunhofer-Institut für Werkstoff- und Strahltechnik IWS, Dresden, Germany.

The scattering properties of biological tissue are highly dependent on the structure size, refractive index, and wavelength of the incident light. Furthermore, these scattering characteristics are strongly influenced by movements of the scattering objects. A method is developed to determine the angular- and spectral-resolved scattering properties that enabled the characterization of biological nano- and microscaled cell structures. Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.121619DOI Listing
December 2018

Analysis of blood coagulation process based on fractality and dynamic characteristic of laser speckle pattern.

J Biomed Opt 2018 Dec;24(3):1-7

Hokkai-Gakuen Univ., Japan.

The reflection and transmission of coherent light from a biological system can yield information about its condition. In the case of blood exposed to the air, there is a change in the properties of the speckle patterns observed in the coagulation process. This can be studied by means of the rate of temporal variation, the contrast, and also the fractality of patterns. Read More

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http://dx.doi.org/10.1117/1.JBO.24.3.031018DOI Listing
December 2018

Back-propagation neural network-based reconstruction algorithm for diffuse optical tomography.

J Biomed Opt 2018 Dec;24(5):1-12

Beijing Univ. of Technology, China.

Diffuse optical tomography (DOT) is a promising noninvasive imaging modality and is capable of providing functional characteristics of biological tissue by quantifying optical parameters. The DOT image reconstruction is ill-posed and ill-conditioned, due to the highly diffusive nature of light propagation in biological tissues and limited boundary measurements. The widely used regularization technique for DOT image reconstruction is Tikhonov regularization, which tends to yield oversmoothed and low-quality images containing severe artifacts. Read More

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http://dx.doi.org/10.1117/1.JBO.24.5.051407DOI Listing
December 2018
2 Reads

MCmatlab: an open-source, user-friendly, MATLAB-integrated three-dimensional Monte Carlo light transport solver with heat diffusion and tissue damage.

J Biomed Opt 2018 Dec;23(12):1-6

Technical University of Denmark, Department of Photonics Engineering, Roskilde, Denmark.

While there exist many Monte Carlo (MC) programs for solving the radiative transfer equation (RTE) in biological tissues, we have identified a need for an open-source MC program that is sufficiently user-friendly for use in an education environment, in which detailed knowledge of compiling or UNIX command-line cannot be assumed. Therefore, we introduce MCmatlab, an open-source codebase thus far consisting of (a) a fast three-dimensional MC RTE solver and (b) a finite-element heat diffusion and Arrhenius-based thermal tissue damage simulator, both run in MATLAB. The kernel for both of these solvers is written in parallelized C and implemented as MATLAB MEX functions, combining the speed of C with the familiarity and versatility of MATLAB. Read More

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https://www.spiedigitallibrary.org/journals/journal-of-biome
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http://dx.doi.org/10.1117/1.JBO.23.12.121622DOI Listing
December 2018
25 Reads

Characterization of healthy and nonmelanoma-induced mouse utilizing the Stokes-Mueller decomposition.

J Biomed Opt 2018 Dec;23(12):1-8

International University-Vietnam National University HCMC, Department of Biomedical Engineering, Ho, Vietnam.

Skin cancer is one of the most common cancers, including melanoma and nonmelanoma cancer. Melanoma can be easily detected by the observation of abnormal moles, but nonmelanoma signs and symptoms are not apparent in the early stages. We use the Stokes-Mueller matrix decomposition method to detect nonmelanoma at the early stage by decomposing the characteristics of polarized light interacting with normal and cancerous tissues. Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.125003DOI Listing
December 2018
7 Reads

Degree of optical polarization as a tool for detecting melanoma: proof of principle.

J Biomed Opt 2018 Dec;23(12):1-7

University of British Columbia, School of Biomedical Engineering, Vancouver, Canada.

Determining the optical polarization properties of a skin lesion is a proposed method to differentiate melanoma from other skin lesions. We developed an in vivo Stokes polarimetry probe that fires a laser of known polarization at the skin and measures the Stokes parameters of the backscattered light in one shot. From these measured Stokes parameters, we can calculate the degree of polarization (DOP). Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.125004DOI Listing
December 2018
4 Reads
2.859 Impact Factor

Photoacoustic response induced by nanoparticle-mediated photothermal bubbles beyond the thermal expansion for potential theranostics.

J Biomed Opt 2018 Dec;23(12):1-12

Xi'an Jiaotong University, School of Life Science and Technology, Key Laboratory of Biomedical Infor, China.

Photoacoustic responses induced by laser-excited photothermal bubbles (PTBs) in colloidal gold solutions are relevant to the theranostics quality in biomedical applications. Confined to the complexity of nonstationary, multiscale events, and multiphysical parameters of PTBs, systematic studies of the photoacoustic effects remain obscure. Photoacoustic effects mediated by PTB dynamics and a physical mechanism are studied based on a proof-of-principle multimodal platform integrating side-scattering imaging, time-resolved optical response, and acoustic detection. Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.125002DOI Listing
December 2018
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Machine learning approach for rapid and accurate estimation of optical properties using spatial frequency domain imaging.

J Biomed Opt 2018 Dec;24(7):1-6

University of Strasbourg, ICube Laboratory, Strasbourg, France.

Fast estimation of optical properties from reflectance measurements at two spatial frequencies could pave way for real-time, wide-field and quantitative mapping of vital signs of tissues. We present a machine learning-based approach for estimating optical properties in the spatial frequency domain, where a random forest regression algorithm is trained over data obtained from Monte-Carlo photon transport simulations. The algorithm learns the nonlinear mapping between diffuse reflectance at two spatial frequencies, and the absorption and reduced scattering coefficient of the tissue under consideration. Read More

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http://dx.doi.org/10.1117/1.JBO.24.7.071606DOI Listing
December 2018
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Suprathreshold laser injuries in excised porcine skin for millisecond exposures at 1070 nm.

J Biomed Opt 2018 Dec;23(12):1-11

711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Optical Radiation Bio, United States.

Skin injury response to near-infrared (NIR) laser radiation between the minimum visible lesion threshold and ablation onset is not well understood. This study utilizes a 1070-nm diode-pumped Yb-fiber laser to explore the response of excised porcine skin to high-energy exposures in the suprathreshold injury region without inducing ablation. Concurrent high-speed videography is employed to determine a dichotomous response for three progressive damage categories: observable surface distortion, surface bubble formation due to contained intracutaneous water vaporization, and surface bubble rupture during exposure. Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.125001DOI Listing
December 2018
3 Reads

Review of light parameters and photobiomodulation efficacy: dive into complexity.

J Biomed Opt 2018 Dec;23(12):1-17

Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts, United States.

Photobiomodulation (PBM) therapy, previously known as low-level laser therapy, was discovered more than 50 years ago, yet there is still no agreement on the parameters and protocols for its clinical application. Some groups have recommended the use of a power density less than 100  mW/cm2 and an energy density of 4 to 10  J/cm2 at the level of the target tissue. Others recommend as much as 50  J/cm2 at the tissue surface. Read More

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http://dx.doi.org/10.1117/1.JBO.23.12.120901DOI Listing
December 2018
2 Reads