37,882 results match your criteria Journal of Biological Regulators & Homeostatic Agents [Journal]


Circulating lncRNA BC030099 Increases in Preeclampsia Patients.

Mol Ther Nucleic Acids 2019 Feb 1;14:562-566. Epub 2019 Feb 1.

Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Long noncoding RNAs (lncRNAs) have increasingly been shown to be important biological regulators involved in numerous diseases. Further, increasing evidence demonstrates that circulating lncRNAs can be used as diagnostic biomarkers. Therefore, the purpose of this study was to evaluate the potential for circulating lncRNAs as novel biomarkers for the diagnosis of preeclampsia. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.01.011DOI Listing
February 2019

G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Monash Institute of Pharmaceutical Sciences, and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia; Columbia University College of Physicians and Surgeons, Columbia University in the City of New York, 21 Audubon Avenue, Rm 209, New York City, NY 10032, USA. Electronic address:

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neurons, and immune cells participate in communication amongst cells. GPCRs control digestion, mediate digestive diseases, and coordinate repair and growth. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.266DOI Listing
February 2019

PPAR-γ: Its ligand and its regulation by microRNAs.

J Cell Biochem 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily. PPARs are categorized into three subtypes, PPARα, β/δ, and γ, encoded by different genes, expressed in diverse tissues and participate in various biological functions and can be activated by their metabolic derivatives in the body or dietary fatty acids. The PPAR-γ also takes parts in the regulation of energy balance, lipoprotein metabolism, insulin sensitivity, oxidative stress, and inflammatory signaling. Read More

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http://dx.doi.org/10.1002/jcb.28419DOI Listing
February 2019

PD-L1 and tumor-associated macrophages in de novo DLBCL.

Blood Adv 2019 Feb;3(4):531-540

Oncology Biomarker Development.

Programmed death-ligand 1 (PD-L1) and its receptor, programmed cell death-1 (PD-1), are important negative regulators of immune cell activation. Therapeutically targeting PD-1/PD-L1 in diffuse large B-cell lymphoma (DLBCL) patients with a single agent has limited activity, meriting a deeper understanding of this complex biology and of available PD-L1 clinical assays. In this study, we leveraged 2 large de novo DLBCL phase 3 trials (GOYA and MAIN) to better understand the biologic and clinical relevance of PD-L1 in de novo DLBCL. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018020602DOI Listing
February 2019

The role of chloroplasts in the oxidative stress that is induced by zearalenone in wheat plants - The functions of 24-epibrassinolide and selenium in the protective mechanisms.

Plant Physiol Biochem 2019 Feb 1;137:84-92. Epub 2019 Feb 1.

Polish Academy of Sciences, The Franciszek Górski Institute of Plant Physiology, Niezapominajek 21, 30-239, Kraków, Poland. Electronic address:

This study focused on the idea that the toxic effect of zearalenone (ZEA) and the protective actions of the brassinosteroid - 24-epibrassinolide (EBR) as well as selenium are dependent on its accumulation in chloroplasts to a high degree. These organelles were isolated from the leaves of oxidative stress-sensitive and stress-tolerant wheat cultivars that had been grown from grains that had been incubated in a solution of ZEA (30 μM), NaSeO (Se, 10 μM), EBR (0.1 μM) or in a mixture of ZEA with Se or EBR. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.01.030DOI Listing
February 2019

Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer.

PLoS One 2019 15;14(2):e0211564. Epub 2019 Feb 15.

Department of Pathology, Haartman Institute, University of Helsinki and HUSLAB, Helsinki, Finland.

Ornithine decarboxylase (ODC) is the rate-limiting enzyme of polyamine synthesis. The two ODC antizyme inhibitors (AZIN1) and (AZIN2) are regulators of the catalytic activity of ODC. While AZIN1 is a regulator of cell proliferation, AZIN2 is involved in intracellular vesicle transport and secretion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211564PLOS
February 2019

Berry transcriptome: Insights into a novel resource to understand development dependent secondary metabolism in Withania Somnifera (Ashwagandha).

Physiol Plant 2019 Feb 15. Epub 2019 Feb 15.

Department of Metabolic and Structural Biology, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, 226015, India.

Withania somnifera (Ashwagandha) is considered as Rasayana in Indian systems of medicine. This study reports a novel transcriptome of W. somnifera berries, with high depth, quality and coverage. Read More

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http://dx.doi.org/10.1111/ppl.12943DOI Listing
February 2019

G2/M inhibitors as pharmacotherapeutic opportunities for glioblastoma: the old, the new, and the future.

Cancer Biol Med 2018 Nov;15(4):354-374

Department of Pediatrics.

Glioblastoma (GBM) is one of the deadliest tumors and has a median survival of 3 months if left untreated. Despite advances in rationally targeted pharmacological approaches, the clinical care of GBM remains palliative in intent. Since the majority of altered signaling cascades involved in cancer establishment and progression eventually affect cell cycle progression, an alternative approach for cancer therapy is to develop innovative compounds that block the activity of crucial molecules needed by tumor cells to complete cell division. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372908PMC
November 2018

Small-Molecules Selectively Modulate Iron-Deficiency Signaling Networks in Arabidopsis.

Front Plant Sci 2019 31;10. Epub 2019 Jan 31.

Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan.

Plant growth requires optimal levels of iron (Fe). Fe is used for energy production, numerous enzymatic processes, and is indispensable for cellular metabolism. Recent studies have established the mechanism involved in Fe uptake and transport. Read More

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https://www.frontiersin.org/article/10.3389/fpls.2019.00008/
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http://dx.doi.org/10.3389/fpls.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365448PMC
January 2019
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A Genome-Wide Screen Identifies Factors Involved in -Induced Human Neutrophil Cell Death and Pathogenesis.

Front Immunol 2019 31;10:45. Epub 2019 Jan 31.

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.

is a commensal organism in approximately 30% of the human population and colonization is a significant risk factor for invasive infection. As a result of this, there is a great need to better understand how overcomes human immunity. Neutrophils are essential during the innate immune response to , yet this microorganism uses multiple evasion strategies to avoid killing by these immune cells, perhaps the most catastrophic of which is the rapid induction of neutrophil cell death. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365652PMC
January 2019

Quantifying dynamic mechanisms of auto-regulation in Escherichia coli with synthetic promoter in response to varying external phosphate levels.

Sci Rep 2019 Feb 14;9(1):2076. Epub 2019 Feb 14.

University of Trento, Department of Mathematics, Trento, 38123, Italy.

Escherichia coli have developed one of the most efficient regulatory response mechanisms to phosphate starvation. The machinery involves a cascade with a two-component system (TCS) that relays the external signal to the genetic circuit, resulting in a feedback response. Achieving a quantitative understanding of this system has implications in synthetic biology and biotechnology, for example, in applications for wastewater treatment. Read More

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http://dx.doi.org/10.1038/s41598-018-38223-wDOI Listing
February 2019

MDH1 and MPP7 regulate autophagy in pancreatic ductal adenocarcinoma.

Cancer Res 2019 Feb 14. Epub 2019 Feb 14.

Molecular Cell Biology of Autophagy, Francis Crick Institute.

Pancreatic ductal adenocarcinoma (PDAC) is driven by metabolic changes in pancreatic cells caused by oncogenic mutations and dysregulation of p53. PDAC cell lines and PDAC-derived xenografts grow as a result of altered metabolic pathways, changes in stroma, and autophagy. Selective targeting and inhibition of one of these may open avenues for the development of new therapeutic strategies. Read More

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-2553DOI Listing
February 2019
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B-box containing proteins BBX30 and BBX31, acting downstream of HY5, negatively regulate photomorphogenesis in Arabidopsis.

Plant Physiol 2019 Feb 14. Epub 2019 Feb 14.

Peking University CITY: Beijing China [CN]

Light-mediated seedling development is coordinately controlled by a variety of key regulators. Here, we identified two B-box (BBX) containing proteins, BBX30 and BBX31, as repressors of photomorphogenesis. ELONGATED HYPOCOTYL 5 (HY5), a central regulator of light signaling, directly binds to the G-box cis-element present in the promoters of BBX30 and BBX31 and negatively controls their transcription levels in the light. Read More

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http://dx.doi.org/10.1104/pp.18.01244DOI Listing
February 2019

Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain.

Dis Model Mech 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical Genetics, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands

Microglia are brain resident macrophages, which have specialized functions important in brain development and in disease. They colonize the brain in early embryonic stages, but few factors that drive the migration of yolk sac macrophages (YSMs) into the embryonic brain , or regulate their acquisition of specialized properties are currently known.Here, we present a CRISPR/Cas9-based in vivo reverse genetic screening pipeline to identify new microglia regulators using zebrafish. Read More

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http://dx.doi.org/10.1242/dmm.037762DOI Listing
February 2019

Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.

Mol Ther 2019 Jan 24. Epub 2019 Jan 24.

Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland.

Activin A and myostatin, members of the transforming growth factor (TGF)-β superfamily of secreted factors, are potent negative regulators of muscle growth, but their contribution to myocardial ischemia-reperfusion (IR) injury is not known. The aim of this study was to investigate if activin 2B (ACVR2B) receptor ligands contribute to myocardial IR injury. Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) and subjected to myocardial ischemia followed by reperfusion for 6 or 24 h. Read More

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http://dx.doi.org/10.1016/j.ymthe.2019.01.013DOI Listing
January 2019

Proportional subcellular localization of Arabidopsis thaliana RabA1a.

Plant Signal Behav 2019 Feb 14:1-4. Epub 2019 Feb 14.

e Department of Biology Education , Kyungpook National University , Daegu , South Korea.

Subcellular localization of trafficking proteins in a single cell affects the assembly of trafficking machinery between organelles and vesicles throughout the targeting pathway. RabGTPase is one of the regulators to direct specific targeting of cargo molecules depending on GDP/GTP bound status. We have recently determined the crystal structures of GDP-bound inactive and both GTP- and GppNHp-bound active forms of Arabidopsis RabA1a. Read More

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http://dx.doi.org/10.1080/15592324.2019.1581561DOI Listing
February 2019

PBS3 protects EDS1 from proteasome-mediated degradation in plant immunity.

Mol Plant 2019 Feb 11. Epub 2019 Feb 11.

Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA. Electronic address:

Plant immunity is mediated by the positive regulators PBS3 and EDS1 and the negative regulators NPR3 and NPR4. However, the relationships among these important immune regulators remain elusive. Here, we show that PBS3 interacts with EDS1 in both the cytoplasm and the nucleus and is required for EDS1 protein accumulation. Read More

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http://dx.doi.org/10.1016/j.molp.2019.01.023DOI Listing
February 2019

Regulation of permeability transition pore opening in mitochondria by external NAD(H).

Biochim Biophys Acta Gen Subj 2019 Feb 11. Epub 2019 Feb 11.

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, Pushchino, Moscow Region 142290, Russia. Electronic address:

Background: The opening of the permeability transition pore (PTP) in mitochondria plays a critical role in the pathogenesis of numerous diseases. Mitochondrial matrix pyridine nucleotides are potent regulators of the PTP, but the role of extramitochondrial nucleotides is unclear.

Methods: The PTP opening was explored in isolated mitochondria and mitochondria in permeabilized differentiated and undifferentiated cells in the presence of added NAD(P)(H) in combination with Mg, adenine nucleotides (AN), and the inhibitors of AN translocase (ANT), voltage-dependent anion channel (VDAC), and cyclophilin D. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.01.003DOI Listing
February 2019

Cathepsins: Potent regulators in carcinogenesis.

Pharmacol Ther 2019 Feb 11. Epub 2019 Feb 11.

Department of Biotechnology, Daegu University, Gyeongsan, Gyeongb, uk-38453, Republic of Korea.. Electronic address:

Cathepsins (CTS) are mainly lysosomal acid hydrolases extensively involved in the prognosis of different diseases, and having a distinct role in tumor progression by regulating cell proliferation, autophagy, angiogenesis, invasion, and metastasis. As all these processes conjunctively lead to cancer progression, their site-specific regulation might be beneficial for cancer treatment. CTS regulate activation of the proteolytic cascade and protein turnover, while extracellular CTS is involved in promoting extracellular matrix degradation and angiogenesis, thereby stimulating invasion and metastasis. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2019.02.003DOI Listing
February 2019

BEIR VI radon: The rest of the story.

Chem Biol Interact 2019 Feb 11. Epub 2019 Feb 11.

Environmental Science, Washington State University, Richland, WA, USA. Electronic address:

The National Academy of Sciences (USA) conducted an extensive review on the health effects of radon (BEIR VI). This was a well written and researched report which had impact on regulations, laws and remediation of radon in homes. There were a number of problems with the interpretation of the report and three are focused on here. Read More

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http://dx.doi.org/10.1016/j.cbi.2018.11.012DOI Listing
February 2019

Cyclin-dependent kinase 21 is a novel regulator of proliferation and meiosis in the male germ line of zebrafish.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

K Siegfried, Biology Department, University of Massachusetts Boston, Boston, 02125, United States.

Germ cell differentiation and maintenance relies on complex regulation of mitotic and meiotic progression. Cyclin-dependent kinases (Cdks) and their activating Cyclin partners are known to have specialized roles in regulating cell-cycle progression across tissues, including in germ cells. Very little is known about Cdk/Cyclin function in zebrafish, or the regulation of germ cell maintenance and differentiation. Read More

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http://dx.doi.org/10.1530/REP-18-0386DOI Listing
February 2019

Cytokine Targeting by miRNAs in Autoimmune Diseases.

Front Immunol 2019 29;10:15. Epub 2019 Jan 29.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Persistent and excessive cytokine production is a hallmark of autoimmune diseases and may play a role in disease pathogenesis and amplification. Therefore, cytokine neutralization is a useful therapeutic strategy to treat immune-mediated conditions. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression in diverse biological processes. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361839PMC
January 2019

The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts.

Mod Pathol 2019 Feb 13. Epub 2019 Feb 13.

Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, UK.

E-cadherin is a tumor suppressor gene in invasive lobular breast cancer. However, a proportion of high-grade ductal carcinoma shows reduced/loss of E-cadherin. In this study, we assessed the underlying mechanisms and molecular implications of E-cadherin loss in invasive ductal carcinoma. Read More

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http://dx.doi.org/10.1038/s41379-019-0209-9DOI Listing
February 2019

A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-κB Activity.

J Immunol 2019 Feb 13. Epub 2019 Feb 13.

Department of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298;

Deregulated immune response to a dysbiotic resident microflora within the oral cavity leads to chronic periodontal disease, local tissue destruction, and various systemic complications. To preserve tissue homeostasis, inflammatory signaling pathways involved in the progression of periodontitis must be tightly regulated. A20 (TNFAIP3), a ubiquitin-editing enzyme, has emerged as one of the key regulators of inflammation. Read More

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1801286
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http://dx.doi.org/10.4049/jimmunol.1801286DOI Listing
February 2019
1 Read

Transcriptional Sequencing Uncovers Survival Mechanisms of Salmonella enterica Serovar Enteritidis in Antibacterial Egg White.

mSphere 2019 Feb 13;4(1). Epub 2019 Feb 13.

MOST-USDA Joint Research Center for Food Safety, School of Agriculture & Biology, and State Key Lab of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China

The survival mechanism of serovar Enteritidis in antibacterial egg white is not fully understood. In our lab, an egg white-resistant strain, Enteritidis SJTUF 10978, was identified. Cell envelope damage and osmotic stress response (separation of cell wall and inner membrane as well as cytoplasmic shrinkage) of this strain surviving in egg white were identified through microscopic observation. Read More

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http://dx.doi.org/10.1128/mSphere.00700-18DOI Listing
February 2019

activity is restricted to the outermost cells of the embryo through post-transcriptional repressions.

Development 2019 Feb 13. Epub 2019 Feb 13.

Department of Biological Sciences, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan

Cell fate determination in plants relies on positional cues. To investigate the position-dependent gene regulation in plants, we focused on shoot epidermal cell specification, which occurs only in the outermost cells. (), which encodes an HD-ZIP class IV transcription factor, is a positive regulator of shoot epidermal cell identity. Read More

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http://dx.doi.org/10.1242/dev.169300DOI Listing
February 2019

Alternative usage of miRNA-biogenesis co-factors in plants at low temperatures.

Development 2019 Feb 13. Epub 2019 Feb 13.

Instituto de Agrobiotecnología del Litoral (CONICET-UNL), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 3000, Santa Fe, Argentina

Plants use molecular mechanisms to sense temperatures, trigger quick adaptive responses, and thereby cope with environmental changes. MicroRNAs (miRNAs) are key regulators of plants' development under such conditions. The catalytic action of DICER LIKE 1 (DCL1), in conjunction with HYPONASTIC LEAVES 1 (HYL1) and SERRATE (SE), produces miRNAs from double-stranded RNAs. Read More

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http://dx.doi.org/10.1242/dev.172932DOI Listing
February 2019

Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models.

Dis Model Mech 2019 Feb 4;12(2). Epub 2019 Feb 4.

Department of Biochemistry and Molecular Medicine, University of California at Davis, School of Medicine, Sacramento, CA 95817, USA

Diverse signaling cues and attendant proteins work together during organogenesis, including craniofacial development. Lip and palate formation starts as early as the fourth week of gestation in humans or embryonic day 9.5 in mice. Read More

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http://dx.doi.org/10.1242/dmm.037051DOI Listing
February 2019

TRAF1 meditates lipopolysaccharide-induced acute lung injury by up regulating JNK activation.

Biochem Biophys Res Commun 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatrics, Ankang Central Hospital, Ankang, 725000, China. Electronic address:

Acute lung injury (ALI) is served as a severe life-threatening disease. However, the pathogenesis that contributes to ALI has not been fully understood. Tumor necrosis factor receptor-associated factor 1 (TRAF1) interacts with multiple regulators, performing its diverse role in biological functions. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.01.041DOI Listing
February 2019

The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer.

J Immunother Cancer 2019 Feb 13;7(1):45. Epub 2019 Feb 13.

Tumor Immunology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy.

Background: The thymic stromal lymphopoietin (TSLP), a key cytokine for development of Th2 immunity, is produced by cancer associated fibroblasts (CAFs) in pancreatic cancer where predominant tumor infiltrating Th2 over Th1 cells correlates with reduced patients' survival. Which cells and molecules are mostly relevant in driving TSLP secretion by CAFs in pancreatic cancer is not defined.

Methods: We performed in vitro, in vivo and ex-vivo analyses. Read More

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http://dx.doi.org/10.1186/s40425-019-0521-4DOI Listing
February 2019

Transcriptomic response is more sensitive to water deficit in shoots than roots of Vitis riparia (Michx.).

BMC Plant Biol 2019 Feb 13;19(1):72. Epub 2019 Feb 13.

McFadden BioStress Laboratory, Agronomy, Horticulture, and Plant Science Department, South Dakota State University, Brookings, SD, 57006, USA.

Background: Drought is an important constraint on grapevine sustainability. Vitis riparia, widely used in rootstock and scion breeding, has been studied in isolated leaf drying response studies; however, it is essential to identify key root and shoot water deficit signaling traits in intact plants. This information will aid improved scion and rootstock selection and management practices in grapevine. Read More

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https://bmcplantbiol.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12870-019-1664-7DOI Listing
February 2019
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MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.

Cell Rep 2019 Feb;26(7):1800-1814.e5

Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

The mechanisms that regulate envelopment of HCV and other viruses that bud intracellularly and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination of the HCV nonstructural (NS) 2 protein mediates HRS (ESCRT-0 component) binding and envelopment. Nevertheless, the ubiquitin signaling that governs NS2 ubiquitination remained unknown. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.075DOI Listing
February 2019

Abnormal effector and regulatory T cell subsets in paediatric-onset multiple sclerosis.

Brain 2019 Feb 12. Epub 2019 Feb 12.

Neuroimmunology Unit, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Suite # 111, Montreal, Quebec, Canada.

Elucidation of distinct T-cell subsets involved in multiple sclerosis immune-pathophysiology continues to be of considerable interest since an ultimate goal is to more selectively target the aberrant immune response operating in individual patients. While abnormalities of both effector (Teff) and regulatory (Treg) T cells have been reported in patients with multiple sclerosis, prior studies have mostly assessed average abnormalities in either limb of the immune response, rather than both at the same time, which limits the ability to evaluate the balance between effectors and regulators operating in the same patient. Assessing both phenotypic and functional responses of Teffs and Tregs has also proven important. Read More

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http://dx.doi.org/10.1093/brain/awz017DOI Listing
February 2019

Maternal and zygotic gene regulatory effects of endogenous RNAi pathways.

PLoS Genet 2019 Feb 13;15(2):e1007784. Epub 2019 Feb 13.

Biology of Non-coding RNA Group, Institute of Molecular Biology, Ackermannweg 4, Mainz, Germany.

Endogenous small RNAs (sRNAs) and Argonaute proteins are ubiquitous regulators of gene expression in germline and somatic tissues. sRNA-Argonaute complexes are often expressed in gametes and are consequently inherited by the next generation upon fertilization. In Caenorhabditis elegans, 26G-RNAs are primary endogenous sRNAs that trigger the expression of downstream secondary sRNAs. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007784DOI Listing
February 2019

Architectural principles for Hfq/Crc-mediated regulation of gene expression.

Elife 2019 Feb 13;8. Epub 2019 Feb 13.

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

In diverse bacterial species, the global regulator Hfq contributes to post-transcriptional networks that control expression of numerous genes. Hfq of the opportunistic pathogen inhibits translation of target transcripts by forming a regulatory complex with the catabolite repression protein Crc. This repressive complex acts part of an intricate mechanism of preferred nutrient utilisation. Read More

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http://dx.doi.org/10.7554/eLife.43158DOI Listing
February 2019

Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis.

Elife 2019 Feb 13;8. Epub 2019 Feb 13.

Biology Department, University of Massachusetts, Amherst, Amherst, United States.

Microtubules (MTs) are essential for cleavage furrow positioning during cytokinesis, but the mechanisms by which MT-derived signals spatially define regions of cortical contractility are unresolved. In this study cytokinesis regulators visualized in () cells were found to localize to and track MT plus-ends during cytokinesis. The RhoA GEF Pebble ( ECT2) did not evidently tip-track, but rather localized rapidly to cortical sites contacted by MT plus-tips, resulting in RhoA activation and enrichment of myosin-regulatory light chain. Read More

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http://dx.doi.org/10.7554/eLife.38968DOI Listing
February 2019
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8.519 Impact Factor

Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signaling.

Exp Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Black Family Stem Cell Institute, The Tisch Cancer Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.

Merkel cells are mechanosensory cells involved in tactile discrimination. Merkel cells have been primarily studied in the murine back skin, where they are found in specialized structures called touch domes located around primary hair follicles. Yet, little is known about the morphogenesis of Merkel cells in areas of the skin devoid of hair, such as the glabrous paw skin. Read More

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http://dx.doi.org/10.1111/exd.13901DOI Listing
February 2019

Integrated Analysis of lncRNA and mRNA Transcriptomes Reveals New Regulators of Ubiquitination and the Immune Response in Silica-Induced Pulmonary Fibrosis.

Biomed Res Int 2019 13;2019:6305065. Epub 2019 Jan 13.

Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing 100850, China.

Objectives: As an epigenetic player, long noncoding RNAs (LncRNAs) have been reported to participate in multiple biological processes; however, their biological functions in silica-induced pulmonary fibrosis (SIPF) occurrence and development remain incompletely understood.

Methods: Five case/control pairs were used to perform integrated transcriptomes analysis of lncRNA and mRNA. Prediction of lncRNA and mRNA functions was aided by the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Read More

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http://dx.doi.org/10.1155/2019/6305065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348882PMC
January 2019

CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.

Oncogene 2019 Feb 12. Epub 2019 Feb 12.

Lundbeckfonden Center of Excellence NanoCAN, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Breast cancer is a heterogeneous genetic disease driven by the accumulation of individual mutations per tumor. Whole-genome sequencing approaches have identified numerous genes with recurrent mutations in primary tumors. Although mutations in well characterized tumor suppressors and oncogenes are overrepresented in these sets, the majority of the genetically altered genes have so far unknown roles in breast cancer progression. Read More

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http://dx.doi.org/10.1038/s41388-019-0739-0DOI Listing
February 2019
1 Read

P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2.

Cell Death Dis 2019 Feb 12;10(2):131. Epub 2019 Feb 12.

General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, 210006, Nanjing, Jiangsu, China.

MicroRNAs (miRNAs) are important class of functional regulators involved in human cancers development, including colorectal cancer (CRC). Exploring aberrantly expressed miRNAs may provide us with new insights into the initiation and development of CRC by functioning as oncogenes or tumor suppressors. The aim of our study is to discover the expression pattern of miR-1249 in CRC and investigate its clinical significance as well as biological role in CRC progression. Read More

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http://www.nature.com/articles/s41419-018-1188-3
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http://dx.doi.org/10.1038/s41419-018-1188-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372610PMC
February 2019
2 Reads

Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer.

Cell Death Dis 2019 Feb 12;10(2):137. Epub 2019 Feb 12.

Department of Gastrointestinal surgery, The Third XiangYa Hospital of Central South University, Changsha, Hunan, 410013, China.

Long noncoding RNAs (lncRNAs) have been indicated as important regulators in various human cancers. However, the overall biological roles and clinical significance of most lncRNAs in colon carcinogenesis are not fully understood. Hence, we investigated the clinical significance, biological function and mechanism of LINC01234 in colon cancer. Read More

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http://dx.doi.org/10.1038/s41419-019-1352-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372696PMC
February 2019
5.014 Impact Factor

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.

Biochem Pharmacol 2019 Feb 9. Epub 2019 Feb 9.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, 77550, USA. Electronic address:

Aging is accompanied by progressive declines in skeletal muscle mass and strength and impaired regenerative capacity, predisposing older adults to debilitating age-related muscle deteriorations and severe morbidity. Muscle stem cells (muSCs) that proliferate, differentiate to fusion-competent myoblasts, and facilitate muscle regeneration are increasingly dysfunctional upon aging, impairing muscle recovery after injury. While regulators of muSC activity can offer novel therapeutics to improve recovery and reduce morbidity among aged adults, there are no known muSC regenerative small molecule therapeutics. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.008DOI Listing
February 2019

Rice shoot and floral meristem development: An overview of developmental regulators of meristem maintenance and organ identity.

J Exp Bot 2019 Feb 9. Epub 2019 Feb 9.

Department of Microbiology and Cell Biology, Indian Institute of Sciences, Bangalore, India.

Grasses have evolved complex inflorescences, where the primary unit is the specialized short branch called a spikelet. Investigations on the cumulative action, of genetic regulators, directing progressive change in axillary meristem identity and their terminal differentiation is crucial to understanding inflorescence complexity and the development of a determinate floret. Grass florets, also pose interesting questions on organ morphologies and functions as compared to other monocots and eudicots. Read More

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http://dx.doi.org/10.1093/jxb/erz046DOI Listing
February 2019

Transcriptional regulation of the genes involved in protein metabolism and processing in Saccharomyces cerevisiae.

FEMS Yeast Res 2019 Feb 11. Epub 2019 Feb 11.

Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.

Topological analysis of large networks, which focus on a specific biological process or on related biological processes, where functional coherence exists among the interacting members, may provide a wealth of insight into cellular functionality. This work presents an unbiased systems approach to analyze genetic, transcriptional regulatory, and physical interaction networks of yeast genes possessing such functional coherence to gain novel biological insight. The present analysis identified only a few transcriptional regulators amongst a large gene cohort associated with the protein metabolism and processing in yeast. Read More

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http://dx.doi.org/10.1093/femsyr/foz014DOI Listing
February 2019
1 Read

Multifaceted activity of cytokinin in leaf development shapes its size and structure in Arabidopsis.

Plant J 2019 Feb 12. Epub 2019 Feb 12.

Department of Molecular Biology and Radiobiology, Faculty of AgriSciences, Mendel University in Brno, Zemědělská 1, CZ-61300, Brno, Czech Republic.

Phytohormone cytokinin has been shown to affect many aspects of plant development ranging from the regulation of the shoot apical meristem to leaf senescence. However some studies reported contradictory effects of cytokinin on leaf physiology. Thus, cytokinin treatments cause both chlorosis and increased greening, and both decrease and increase in cell size. Read More

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http://doi.wiley.com/10.1111/tpj.14285
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http://dx.doi.org/10.1111/tpj.14285DOI Listing
February 2019
5 Reads

Bioinspired Small-Molecule Tools for the Imaging of Redox Biology.

Acc Chem Res 2019 Feb 12. Epub 2019 Feb 12.

School of Chemistry , The University of Sydney , Sydney , NSW 2006 , Australia.

The availability of electrons to biological systems underpins the mitochondrial electron transport chain (ETC) that powers living cells. It is little wonder, therefore, that the sufficiency of electron supply is critical to cellular health. Considering mitochondrial redox activity alone, a lack of oxygen (hypoxia) leads to impaired production of adenosine triphosphate (ATP), the major energy currency of the cell, whereas excess oxygen (hyperoxia) is associated with elevated production of reactive oxygen species (ROS) from the interaction of oxygen with electrons that have leaked from the ETC. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.8b00368
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http://dx.doi.org/10.1021/acs.accounts.8b00368DOI Listing
February 2019
2 Reads

Trypanosoma carassii infection in goldfish (Carassius auratus L.): changes in the expression of erythropoiesis and anemia regulatory genes.

Parasitol Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Biological Sciences, CW-405 Biological Sciences Building, University of Alberta, Edmonton, AB, T6G 2E9, Canada.

Trypanosoma carassii is a flagellated bloodstream parasite of cyprinid fish with pathogenesis manifesting primarily as anemia in experimentally infected fish. This anemia is characterized by decreases in the number of circulating red blood cells (RBCs) during peak parasitemia. We examined changes in the key blood metrics and expression of genes known to be important in the regulation of erythropoiesis. Read More

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http://dx.doi.org/10.1007/s00436-019-06246-5DOI Listing
February 2019

Unique Patterns and Biogeochemical Relevance of Two-Component Sensing in Marine Bacteria.

mSystems 2019 Jan-Feb;4(1). Epub 2019 Feb 5.

Marine Chemistry and Geochemistry Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, USA.

Two-component sensory (TCS) systems link microbial physiology to the environment and thus may play key roles in biogeochemical cycles. In this study, we surveyed the TCS systems of 328 diverse marine bacterial species. We identified lifestyle traits such as copiotrophy and diazotrophy that are associated with larger numbers of TCS system genes within the genome. Read More

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http://msystems.asm.org/lookup/doi/10.1128/mSystems.00317-18
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http://dx.doi.org/10.1128/mSystems.00317-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365647PMC
February 2019
2 Reads

FBXO22 Suppresses Metastasis in Human Renal Cell Carcinoma via Inhibiting MMP-9-Mediated Migration and Invasion and VEGF-Mediated Angiogenesis.

Int J Biol Sci 2019 24;15(3):647-656. Epub 2019 Jan 24.

Cancer Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, Shandong Province, China.

F-box only protein 22 (FBXO22), a substrate receptor of the SKP1-Cullin 1-F-box protein (SCF) E3 ubiquitin ligase that targets key regulators of cellular activities for ubiquitylation and degradation, plays important roles in the progression of human cancer. However, little is known about the role of FBXO22 in renal cell carcinoma (RCC). This study aims to explore the biological function of FBXO22 in RCC progression and its specific regulation mechanism. Read More

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http://www.ijbs.com/v15p0647.htm
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http://dx.doi.org/10.7150/ijbs.31293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367582PMC
January 2019
3 Reads

Cancer epigenetics in solid organ tumours: A primer for surgical oncologists.

Eur J Surg Oncol 2019 Feb 5. Epub 2019 Feb 5.

Department of Clinical Surgery, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK; Gastrointestinal Translational Research Unit, Laboratory for Molecular Biology, Stavanger University Hospital, Stavanger, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway. Electronic address:

Cancer is initiated through both genetic and epigenetic alterations. The end-effect of such changes to the DNA machinery is a set of uncontrolled mechanisms of cell division, invasion and, eventually, metastasis. Epigenetic changes are now increasingly appreciated as an essential driver to the cancer phenotype. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.02.005DOI Listing
February 2019