38,573 results match your criteria Journal of Biological Regulators & Homeostatic Agents [Journal]


Identification of Novel Phospholipid Transfer Protein Inhibitors by High-Throughput Screening.

SLAS Discov 2019 Apr 24:2472555219842210. Epub 2019 Apr 24.

1 Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Takatsuki, Osaka, Japan.

Atherogenesis has been recognized as a risk factor for lethal cardiovascular diseases. Plasma low-density lipoprotein levels are correlated to the occurrence of atherosclerosis, and their control is critical for both the prevention and treatment of these diseases. Phospholipid transfer protein (PLTP) is one of the key regulators of lipoprotein metabolism; PLTP-deficient mice exhibit decreased apolipoprotein B (apoB)-containing lipoprotein secretion and atherosclerosis, indicating the validity of PLTP as a promising therapeutic target. Read More

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http://dx.doi.org/10.1177/2472555219842210DOI Listing

Long noncoding RNAs: Novel regulators of virus-host interactions.

Rev Med Virol 2019 Apr 23:e2046. Epub 2019 Apr 23.

Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong Province, Taishan Medical University, Taian, China.

Long noncoding RNAs (lncRNAs) represent a key class of cellular regulators, involved in the modulation and control of multiple biological processes. Distinct classes of lncRNAs are now known to be induced by host cytokines following viral infections. Current evidence demonstrates that lncRNAs play essential roles at the host-pathogen interface regulating viral infections by either innate immune responses at various levels including activation of pathogen recognition receptors or by epigenetic, transcriptional, and posttranscriptional effects. Read More

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http://dx.doi.org/10.1002/rmv.2046DOI Listing

MicroRNA-203 reinforces stemness properties in melanoma and augments tumorigenesis in vivo.

J Cell Physiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

One of the challenges encountered in microRNA (miRNA) studies is to observe their dual role in different conditions and cells. This leads to a tougher prediction of their behavior as gene expression regulators. miR-203 has been identified to play a negative role in the progression of malignant melanoma; however, it has been reported, with dual effect, as both an oncomiR and tumor suppressor miRNA in some malignancies, such as breast cancer, meanwhile, the role of miR-203 in melanoma stem cells or even metastatic cells is unclear. Read More

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http://dx.doi.org/10.1002/jcp.28619DOI Listing
April 2019
2 Reads

Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes.

Sci Rep 2019 Apr 23;9(1):6424. Epub 2019 Apr 23.

Laboratory of Basic Sciences, Faculty of Dentistry, School of Health Sciences, National and Kapodistrian University of Athens (NKUA), Athens, Greece.

The increasing concern for the reproductive toxicity of abundantly used phthalates requires reliable tools for exposure risk assessment to mixtures of chemicals, based on real life human exposure and disorder-associated epidemiological evidence. We herein used a mixture of four phthalate monoesters (33% mono-butyl phthalate, 16% mono-benzyl phthalate, 21% mono-ethyl hexyl phthalate, and 30% mono-isononyl phthalate), detected in 1 trimester urine of 194 pregnant women and identified as bad actors for a shorter anogenital distance (AGD) in their baby boys. Mice were treated with 0, 0. Read More

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http://dx.doi.org/10.1038/s41598-019-42377-6DOI Listing

RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point.

Nat Commun 2019 Apr 23;10(1):1897. Epub 2019 Apr 23.

Department of Biochemistry, School of Medicine, and Institute for Tumor Research, Chungbuk National University, Cheongju, 28644, South Korea.

The cellular decision regarding whether to undergo proliferation or death is made at the restriction (R)-point, which is disrupted in nearly all tumors. The identity of the molecular mechanisms that govern the R-point decision is one of the fundamental issues in cell biology. We found that early after mitogenic stimulation, RUNX3 binds to its target loci, where it opens chromatin structure by sequential recruitment of Trithorax group proteins and cell-cycle regulators to drive cells to the R-point. Read More

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http://dx.doi.org/10.1038/s41467-019-09810-wDOI Listing

2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice.

Sci Rep 2019 Apr 24;9(1):6514. Epub 2019 Apr 24.

Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.

Aryl hydrocarbon receptor (AhR) activation is reported to alter the hepatic expression of circadian clock regulators, however the impact on clock-controlled metabolism has not been thoroughly investigated. This study examines the effects of AhR activation on hepatic transcriptome and metabolome rhythmicity in male C57BL/6 mice orally gavaged with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) every 4 days for 28 days. TCDD diminished the rhythmicity of several core clock regulators (e. Read More

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http://dx.doi.org/10.1038/s41598-019-42760-3DOI Listing

Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism.

Nat Commun 2019 Apr 23;10(1):1841. Epub 2019 Apr 23.

Institute of Molecular Systems Biology, ETH Zurich, Otto-Stern-Weg 3, CH-8093, Zurich, Switzerland.

Transcriptional reprogramming of cellular metabolism is a hallmark of cancer. However, systematic approaches to study the role of transcriptional regulators (TRs) in mediating cancer metabolic rewiring are missing. Here, we chart a genome-scale map of TR-metabolite associations in human cells using a combined computational-experimental framework for large-scale metabolic profiling of adherent cell lines. Read More

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http://dx.doi.org/10.1038/s41467-019-09695-9DOI Listing

Methylation of C/EBPα by PRMT1 inhibits its tumor suppressive function in breast cancer.

Cancer Res 2019 Apr 23. Epub 2019 Apr 23.

Biochemistry and Molecular Biology, Peking Union Medical College & Chinese Academy of Medical Sciences

C/EBPα is an essential transcription factor involved in regulating the expression or function of certain cell cycle regulators, including in breast cancer cells. Although protein arginine methyltransferases have been shown to play oncogenic roles in a variety of cancers, little is known about the role of arginine methylation in regulating the antiproliferation activity of C/EBPα. Here we report that the protein arginine methyltransferase 1 (PRMT1) is overexpressed in human breast cancer and that elevated PRMT1 correlates with cancer malignancy. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3211DOI Listing

is required for the integrity of the photoreceptor layer in the zebrafish retina.

Biol Open 2019 Apr 23;8(4). Epub 2019 Apr 23.

Max-Planck-Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108 01307 Dresden, Germany

The vertebrate retina is a complex tissue built from multiple neuronal cell types, which develop from a pseudostratified neuroepithelium. These cells are arranged into a highly organized and stereotypic pattern formed by nuclear and plexiform layers. The process of lamination as well as the maturation and differentiation of photoreceptor cells rely on the establishment and maintenance of apico-basal cell polarity and formation of adhesive junctions. Read More

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http://dx.doi.org/10.1242/bio.041830DOI Listing

Small non-coding RNAs as important players, biomarkers and therapeutic targets in multiple sclerosis: A comprehensive overview.

J Autoimmun 2019 Apr 20. Epub 2019 Apr 20.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Multiple sclerosis (MS) is a leading cause of progressive disability among young adults caused by inflammation, demyelination and axonal loss in the central nervous system. Small non-coding RNAs (sncRNAs) are important regulators of various biological processes and could therefore play important roles in MS. Over the past decade, a large number of studies investigated sncRNAs in MS patients, focusing primarily on microRNAs (miRNAs). Read More

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http://dx.doi.org/10.1016/j.jaut.2019.04.002DOI Listing
April 2019
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Long non-coding RNA00882 contributes to platelet-derived growth factor-induced proliferation of human fetal airway smooth muscle cells by enhancing Wnt/β-catenin signaling via sponging miR-3619-5p.

Biochem Biophys Res Commun 2019 Apr 20. Epub 2019 Apr 20.

Yulin No.2 Hospital, Yulin City, Shaanxi, 719000, China.

Long non-coding RNAs (lncRNAs) are emerging as novel and critical regulators in the pathogenesis of asthma. However, the precise role of lncRNAs in pediatric asthma remains largely unknown. In this study, we aimed to investigate the biological function of lncRNA00882 (LINC00882) in regulating the proliferation of fetal airway smooth muscle (ASM) cells, which play an important role in airway remodeling during asthma development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193074
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http://dx.doi.org/10.1016/j.bbrc.2019.04.106DOI Listing
April 2019
1 Read

[Study on the Metabolic Reprogramming of Lung Cancer Cells Regulated by Docetaxel Based on Metabolomics].

Zhongguo Fei Ai Za Zhi 2019 Apr;22(4):208-215

Department of Thoracic Surgery, Cancer Hospital, China Medical University, Shenyang 110042, China.

Background: Docetaxel is a commonly used anti-tumor drug in clinic, especially as the first-line drug for advanced non-small cell lung cancer (NSCLC). However, the molecular mechanism of docetaxel against NSCLC is still unclear. Increasing studies have shown that metabolic reprogramming of tumor cells plays an important role in tumorigenesis. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.04.02DOI Listing

Three BnaIAA7 homologs are involved in auxin/brassinosteroid-mediated plant morphogenesis in rapeseed (Brassica napus L.).

Plant Cell Rep 2019 Apr 22. Epub 2019 Apr 22.

Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Wuhan, 430062, China.

Key Message: BnaIAA7 crosstalk with BR signaling is mediated by the interaction between BnaARF8 and BnaBZR1 to regulate rapeseed plant morphogenesis. Auxin (indole-3-acetic acid, IAA) and brassinosteroids (BRs) are essential regulators of plant morphogenesis. However, their roles in rapeseed have not been reported. Read More

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http://dx.doi.org/10.1007/s00299-019-02410-4DOI Listing

SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue.

Diabetes 2019 Apr 22. Epub 2019 Apr 22.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China, 201203

The unique thermogenic capacity of brown adipocyte makes it an attractive target for anti-obesity treatments. Several epigenetic regulators can control brown adipocyte development. Here, we show that SIRT5, a member of the sirtuins, is required for brown adipocyte differentiation and essential for brown adipogenic gene activation Furthermore, we find out that knockdown of SIRT5 reduces intracellular α-ketoglutarate concentration, which led to elevated H3K9me2 and H3K9me3 levels at promoter regions of and loci. Read More

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-1103DOI Listing
April 2019
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Tbx6 induces cardiomyocyte proliferation in postnatal and adult mouse hearts.

Biochem Biophys Res Commun 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennoudai, Tsukuba City, Ibaraki, 305-8575, Japan. Electronic address:

Cardiovascular disease is a leading cause of death worldwide. Mammalian cardiomyocytes (CMs) proliferate during embryonic development, whereas they largely lose their regenerative capacity after birth. Defined factors expressed in cardiac progenitors or embryonic CMs may activate the cell cycle and induce CM proliferation in postnatal and adult hearts. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.04.087DOI Listing

Long Non-Coding RNAs and the Innate Immune Response.

Noncoding RNA 2019 Apr 19;5(2). Epub 2019 Apr 19.

Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

Innate immunity provides the initial defence against infection and it is now clear that long non-coding RNAs (lncRNAs) are important regulators of this response. Following activation of the innate response, we commonly see rapid induction of these lncRNAs and this is often mediated via the pro-inflammatory transcription factor, nuclear factor-κB (NF-κB). Knockdown studies have shown that lncRNAs tend to act in trans to regulate the expression of multiple inflammatory mediators and other responses. Read More

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https://www.mdpi.com/2311-553X/5/2/34
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http://dx.doi.org/10.3390/ncrna5020034DOI Listing
April 2019
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Salvianolic acid B inhibits Ang II-induced VSMC proliferation in vitro and intimal hyperplasia in vivo by downregulating miR-146a expression.

Phytomedicine 2018 Nov 12;58:152754. Epub 2018 Nov 12.

Department of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University, Shijiazhuang, Hebei 050017, China. Electronic address:

Background: Salvianolic acid B (Sal B), a water-soluble compound extracted from Salvia miltiorrhiza that has been widely used to treat cardiovascular diseases for hundreds of years in China, exerts cardiovascular protection by multiple mechanisms. miR-146a is involved in vascular smooth muscle cell (VSMC) phenotypic modulation and proliferation. However, it has yet to be investigated whether the cardiovascular protective effect of Sal B is mediated by miR-146a. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.014DOI Listing
November 2018

Integration of Multiple Data Sources for Gene Network Inference Using Genetic Perturbation Data.

J Comput Biol 2019 Apr 22. Epub 2019 Apr 22.

3 School of Engineering and Technology, University of Washington, Tacoma, Washington.

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http://dx.doi.org/10.1089/cmb.2019.0036DOI Listing
April 2019
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Systems biology based meth-miRNA-mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression.

Cancer Cell Int 2019 8;19:89. Epub 2019 Apr 8.

Department of Biological Sciences, National University of Medical Sciences (NUMS), Abid Majeed Road, Rawalpindi, Pakistan.

Background: Hepatocellular carcinoma (HCC) is one of the leading cause of cancer associated deaths worldwide. Independent studies have proposed altered DNA methylation pattern and aberrant microRNA (miRNA) levels leading to abnormal expression of different genes as important regulators of disease onset and progression in HCC. Here, using systems biology approaches, we aimed to integrate methylation, miRNA profiling and gene expression data into a regulatory methylation-miRNA-mRNA (meth-miRNA-mRNA) network to better understand the onset and progression of the disease. Read More

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http://dx.doi.org/10.1186/s12935-019-0804-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454777PMC

Proteins as the Molecular Markers of Male Fertility.

J Hum Reprod Sci 2019 Jan-Mar;12(1):19-23

Department of Biochemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

Proteins play a key role in many functions such as metabolic activity, differentiation, as cargos, and cell fate regulators. It is necessary to know about the proteins involved in male fertility to develop remedies for the treatment of male infertility. However, the role of the proteins is not limited to particular aspect in the biological systems. Read More

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http://www.jhrsonline.org/text.asp?2019/12/1/19/255785
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http://dx.doi.org/10.4103/jhrs.JHRS_9_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472198PMC
April 2019
6 Reads

MicroRNAs as regulators and effectors of hematopoietic transcription factors.

Wiley Interdiscip Rev RNA 2019 Apr 21:e1537. Epub 2019 Apr 21.

Department of Physiology, Center for Stem Cell Biology and Regenerative Medicine, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.

Hematopoiesis is a highly-regulated development process orchestrated by lineage-specific transcription factors that direct the generation of all mature blood cells types, including red blood cells, megakaryocytes, granulocytes, monocytes, and lymphocytes. Under homeostatic conditions, the hematopoietic system of the typical adult generates over 10 blood cells daily throughout life. In addition, hematopoiesis must be responsive to acute challenges due to blood loss or infection. Read More

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http://dx.doi.org/10.1002/wrna.1537DOI Listing

Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways†.

Eur J Cardiothorac Surg 2019 Apr 21. Epub 2019 Apr 21.

Department of Surgery, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Objectives: Thoracic endovascular techniques for aneurysm repair offer less invasive alternatives to open strategies. Both approaches, however, are associated with the risk for neurological complications. Despite adjuncts to maintain spinal cord perfusion, ischaemia and paraplegia continue to occur during thoracoabdominal aortic aneurysm (TAAA) repair. Read More

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http://dx.doi.org/10.1093/ejcts/ezz113DOI Listing
April 2019
1 Read

24-Epibrassinolide alters DNA cytosine methylation of Linum usitatissimum L. under salinity stress.

Plant Physiol Biochem 2019 Apr 13;139:478-484. Epub 2019 Apr 13.

Institute of Biotechnology, Urmia University, Urmia, Iran; Department of Plant Breeding and Biotechnology, Faculty of Agriculture, Urmia University, Urmia, Iran.

Salinity is a common environmental challenge limiting worldwide agricultural crop yield. Plants employ epigenetic regulatory strategies, such as DNA methylation which relatively allows rapid adaptation to new conditions in response to environmental stresses. Brassinosteroids (BRs) are a novel group of phytohormones recognized as transcription and translation regulators which are able to mitigate the impact of environmental stresses on the plants. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.04.010DOI Listing
April 2019
3 Reads

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.

Mol Cell 2019 Apr 15. Epub 2019 Apr 15.

Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Wellington Road, Clayton, VIC 3800, Australia. Electronic address:

Self-renewal and pluripotency of the embryonic stem cell (ESC) state are established and maintained by multiple regulatory networks that comprise transcription factors and epigenetic regulators. While much has been learned regarding transcription factors, the function of epigenetic regulators in these networks is less well defined. We conducted a CRISPR-Cas9-mediated loss-of-function genetic screen that identified two epigenetic regulators, TAF5L and TAF6L, components or co-activators of the GNAT-HAT complexes for the mouse ESC (mESC) state. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10972765193022
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http://dx.doi.org/10.1016/j.molcel.2019.03.025DOI Listing
April 2019
1 Read
14.018 Impact Factor

Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL.

Biochim Biophys Acta Proteins Proteom 2019 Apr 17. Epub 2019 Apr 17.

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center,Kansas City, KS 66160, USA. Electronic address:

Bcl-xL is a member of the Bcl-2 family of apoptotic regulators, responsible for inhibiting the permeabilization of the mitochondrial outer membrane, and a promising anti-cancer target. Bcl-xL exists in the following conformations, each believed to play a role in the inhibition of apoptosis: (a) a soluble folded conformation, (b) a membrane-anchored (by its C-terminal α8 helix) form, which retains the same fold as in solution and (c) refolded membrane-inserted conformations, for which no structural data are available. Previous studies established that in the cell Bcl-xL exists in a dynamic equilibrium between soluble and membranous states, however, no direct evidence exists in support of either anchored or inserted conformation of the membranous state in vivo. Read More

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http://dx.doi.org/10.1016/j.bbapap.2019.04.006DOI Listing
April 2019
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Potential role of lncRNA-TSIX, miR-548-a-3p, and SOGA1 mRNA in the diagnosis of hepatocellular carcinoma.

Mol Biol Rep 2019 Apr 19. Epub 2019 Apr 19.

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, P.O. Box 11381, Egypt.

Recent trends are moving towards the use of the circulating transcriptome as a potential diagnostic and therapeutic tool for hepatocellular carcinoma (HCC). The aim of this study is to identify circulatory RNA based biomarker panel, in addition to their relationship to the outcome in HCC. First, utilizing bioinformatics tools, we selected an HCC-specific RNA-based biomarker panel that depended on the integration of suppressor of glucose autophagy-associated (SOGA1) gene expression with the chosen panel of epigenetic regulators of this gene [long non-coding RNA antisense for X-inactive-specific transcript (lncRNA-TSIX) and microRNA-548-a-3p (miR-548-a-3p)]. Read More

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http://link.springer.com/10.1007/s11033-019-04810-x
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http://dx.doi.org/10.1007/s11033-019-04810-xDOI Listing
April 2019
1 Read

The circadian clock gene is required to control the timing of retinal neurogenesis and lamination of Müller glia in the mouse retina.

FASEB J 2019 Apr 19:fj201801832RR. Epub 2019 Apr 19.

Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

A single pool of multipotent retinal progenitor cells give rise to the diverse cell types within the mammalian retina. Such cellular diversity is due to precise control of various cellular processes like cell specification, proliferation, differentiation, and maturation. Circadian clock genes can control the expression of key regulators of cell cycle progression and therefore can synchronize the cell cycle state of a heterogeneous population of cells. Read More

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http://dx.doi.org/10.1096/fj.201801832RRDOI Listing
April 2019
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Tomato fruit ripening factor NOR controls leaf senescence.

J Exp Bot 2019 Apr 19. Epub 2019 Apr 19.

Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg, Potsdam-Golm, Germany.

NAC transcription factors (TFs) are important regulators of expressional reprogramming during plant development, stress responses, and leaf senescence. NAC TFs also play important roles in fruit ripening. In tomato (Solanum lycopersicum), one of the best characterized NACs involved in fruit ripening is NON-RIPENING (NOR), and the non-ripening (nor) mutation has been widely used to extend fruit shelf life in elite varieties. Read More

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https://academic.oup.com/jxb/advance-article/doi/10.1093/jxb
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http://dx.doi.org/10.1093/jxb/erz098DOI Listing
April 2019
1 Read

Analysis of DrkA kinase's role in STATa activation.

Genes Cells 2019 Apr 19. Epub 2019 Apr 19.

Department of Biology, Faculty of Science, Toho University, Funabashi, Chiba, 274-8510, Japan.

Dictyostelium STATa is a homologue of metazoan signal transducers and activators of transcription (STATs) and is important for morphogenesis. STATa is activated by phosphorylation on Tyr702 when cells are exposed to extracellular cAMP. Although two tyrosine kinase-like (TKL) proteins, Pyk2 and Pyk3, have been definitively identified as STATc kinases, no kinase is known for STATa activation. Read More

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http://dx.doi.org/10.1111/gtc.12686DOI Listing

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.

Autophagy 2019 Apr 19:1-17. Epub 2019 Apr 19.

a Department of Cell Biology and Biophysics, Faculty of Biology , National and Kapodistrian University of Athens , Athens , Greece.

The ubiquitin-proteasome pathway (UPP) is central to proteostasis network (PN) functionality and proteome quality control. Yet, the functional implication of the UPP in tissue homeodynamics at the whole organism level and its potential cross-talk with other proteostatic or mitostatic modules are not well understood. We show here that knock down (KD) of proteasome subunits in Drosophila flies, induced, for most subunits, developmental lethality. Read More

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http://dx.doi.org/10.1080/15548627.2019.1596477DOI Listing

circRAD18 sponges miR-208a/3164 to promote triple-negative breast cancer progression through regulating IGF1 and FGF2 expression.

Carcinogenesis 2019 Apr 17. Epub 2019 Apr 17.

Department of Breast Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China.

As a new rising star of non-coding RNA, circular RNAs (circRNAs) emerged as vital regulators with biological functions in diverse of cancers. However, the function and precise mechanism of the vast majority of circRNAs in triple-negative breast cancer (TNBC) occurrence and progression have not been clearly elucidated. In the current study, we identified and further investigated hsa_circ_0002453 (circRAD18) by analyzing our previous microarray profiling. Read More

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http://dx.doi.org/10.1093/carcin/bgz071DOI Listing

The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli.

Sci Adv 2019 Apr 17;5(4):eaav1472. Epub 2019 Apr 17.

IRCCS San Raffaele Scientific Institute, Division of Genetics and Cell Biology, Milano, Italy.

Obesity and its associated metabolic abnormalities have become a global emergency with considerable morbidity and mortality. Epidemiologic and animal model data suggest an epigenetic contribution to obesity. Nevertheless, the cellular and molecular mechanisms through which epigenetics contributes to the development of obesity remain to be elucidated. Read More

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http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aav
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http://dx.doi.org/10.1126/sciadv.aav1472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469946PMC
April 2019
1 Read

Generation and Characterization of Germline-Specific Autophagy and Mitochondrial Reactive Oxygen Species Reporters in .

Front Cell Dev Biol 2019 3;7:47. Epub 2019 Apr 3.

Developmental Biology Group, Agharkar Research Institute, Pune, India.

Oogenesis is a fundamental process that forms the egg and, is crucial for the transmission of genetic information to the next generation. oogenesis has been used extensively as a genetically tractable model to study organogenesis, niche-germline stem cell communication, and more recently reproductive aging including germline stem cell (GSC) aging. Autophagy, a lysosome-mediated degradation process, is implicated in gametogenesis and aging. Read More

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http://dx.doi.org/10.3389/fcell.2019.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456670PMC

Immunology's Coming of Age.

Front Immunol 2019 3;10:684. Epub 2019 Apr 3.

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.

This treatise describes the development of immunology as a scientific discipline with a focus on its foundation. Toward the end of the nineteenth century, the study of immunology was founded with the discoveries of phagocytosis by Elias Metchnikoff, as well as by Emil Behring's and Paul Ehrlich's discovery of neutralizing antibodies. These seminal studies were followed by the discoveries of bacteriolysis by complement and of opsonization by antibodies, which provided first evidence for cooperation between acquired and innate immunity. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456699PMC
April 2019
2 Reads

Roles of CircRNAs in Autoimmune Diseases.

Front Immunol 2019 2;10:639. Epub 2019 Apr 2.

Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.

Circular RNAs (circRNAs) are covalently linked single-stranded RNAs, compared to linear counterparts that are relatively abundant, conserved, stable, and specific. Previously, most studies have revealed that circRNAs function in gene expression processes and participate in the pathogenesis of cancers, cardiovascular diseases, and neurological diseases. With advances in biotechnology, more biological functions of circRNAs have been found in several signaling pathways that are related to tumorigenesis, immunity, and metabolism. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00639
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http://dx.doi.org/10.3389/fimmu.2019.00639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454857PMC
April 2019
1 Read

Opposite T Response of ACTG1-FOS Subnetwork Differentiate Tailfin Fate in Xenopus Tadpole and Post-hatching Axolotl.

Front Endocrinol (Lausanne) 2019 2;10:194. Epub 2019 Apr 2.

Unité Mixte de Recherche 7221, Centre National de la Recherche Scientifique, Alliance Sorbonne Université, Muséum National d'Histoire Naturelle, Paris, France.

Amphibian post-embryonic development and Thyroid Hormones (TH) signaling are deeply and intimately connected. In anuran amphibians, TH induce the spectacular and complex process known as metamorphosis. In paedomorphic salamanders, at similar development time, raising levels of TH fail to induce proper metamorphosis, as many "larval" tissues (e. Read More

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http://dx.doi.org/10.3389/fendo.2019.00194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454024PMC
April 2019
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APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 Phase in Multicellular Systems.

Authors:
Yuu Kimata

Trends Cell Biol 2019 Apr 15. Epub 2019 Apr 15.

School of Life Science and Technology, ShanghaiTech University, Shanghai, China; University of Cambridge, Cambridge, UK. Electronic address:

The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology of multicellular organisms is far from complete. Here, I review recent advances in the function of APC/C in animal development, specifically focusing on its emerging role in regulating cell differentiation. Read More

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http://dx.doi.org/10.1016/j.tcb.2019.03.001DOI Listing
April 2019
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Pitaya HpWRKY3 Is Associated with Fruit Sugar Accumulation by Transcriptionally Modulating Sucrose Metabolic Genes and .

Int J Mol Sci 2019 Apr 17;20(8). Epub 2019 Apr 17.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Provincial Key Laboratory of Postharvest Science of Fruits and Vegetables/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (South China) of Ministry of Agriculture/Engineering Research Center of Southern Horticultural Products Preservation, Ministry of Education, College of Horticulture, South China Agricultural University, Guangzhou 510642, China.

Sugar level is an important determinant of fruit taste and consumer preferences. However, upstream regulators that control sugar accumulation during fruit maturation are poorly understood. In the present work, we found that glucose is the main sugar in mature pitaya () fruit, followed by fructose and sucrose. Read More

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http://dx.doi.org/10.3390/ijms20081890DOI Listing
April 2019
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Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial habenula during reinstatement of cocaine-associated behavior.

Neuropharmacology 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurobiology and Behavior, School of Biological Sciences University of California, Irvine, USA; UC Irvine Center for Addiction Neuroscience, School of Biological Sciences, University of California, Irvine, USA; Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine, USA. Electronic address:

Propensity to relapse following long-periods of abstinence is a key feature of substance use disorder. Drugs of abuse, such as cocaine, cause long-term changes in the neural circuitry regulating reward, motivation, and memory processes through dysregulation of various molecular mechanisms, including epigenetic regulation of activity-dependent gene expression. Underlying drug-induced changes to neural circuit function are the molecular mechanisms regulating activity-dependent gene expression. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.016DOI Listing

Senescence as a main mechanism of Ritonavir and Ritonavir-NO action against melanoma.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Department of Immunology, Institute for Biological Research "Siniša Stanković", Belgrade University, Belgrade, Serbia.

The main focus of this study is exploring the effect and mechanism of two HIV-protease inhibitors: Ritonavir and Ritonavir-nitric oxide (Ritonavir-NO) on in vitro growth of melanoma cell lines. NO modification significantly improved the antitumor potential of Ritonavir, as the IC values of Ritonavir-NO were approximately two times lower than IC values of the parental compound. Our results showed for the first time, that both compounds induced senescence in primary and metastatic melanoma cell lines. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23020
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http://dx.doi.org/10.1002/mc.23020DOI Listing
April 2019
5 Reads

A screening platform to monitor RNA processing and protein-RNA interactions in ribonuclease P uncovers a small molecule inhibitor.

Nucleic Acids Res 2019 Apr 18. Epub 2019 Apr 18.

Department of Biochemistry and Structural Biology, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Ribonucleoprotein (RNP) complexes and RNA-processing enzymes are attractive targets for antibiotic development owing to their central roles in microbial physiology. For many of these complexes, comprehensive strategies to identify inhibitors are either lacking or suffer from substantial technical limitations. Here, we describe an activity-binding-structure platform for bacterial ribonuclease P (RNase P), an essential RNP ribozyme involved in 5' tRNA processing. Read More

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http://dx.doi.org/10.1093/nar/gkz285DOI Listing

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer.

Oncogene 2019 Apr 17. Epub 2019 Apr 17.

Knight Cancer Institute, Oregon Health & Science University, Portland, OR, 97239, USA.

BET bromodomain inhibitors block prostate cancer cell growth at least in part through c-Myc and androgen receptor (AR) suppression. However, little is known about other transcriptional regulators whose suppression contributes to BET bromodomain inhibitor anti-tumor activity. Moreover, the anti-tumor activity of BET bromodomain inhibition in AR-independent castration-resistant prostate cancers (CRPC), whose frequency is increasing, is also unknown. Read More

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http://www.nature.com/articles/s41388-019-0815-5
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http://dx.doi.org/10.1038/s41388-019-0815-5DOI Listing
April 2019
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GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation.

Immunity 2019 Apr;50(4):796-811

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA. Electronic address:

The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also participates in the resolution of inflammation, and IL-3 and IL-5 may also have such properties. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193013
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http://dx.doi.org/10.1016/j.immuni.2019.03.022DOI Listing
April 2019
9 Reads

Non-muscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.

Mol Biol Cell 2019 Apr 17:mbcE18120790. Epub 2019 Apr 17.

School of Biological Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.

Though many cancers are known to show upregulation of Nonmuscle myosin (NM) IIA and -IIB, the mechanism by which NMIIs aid in cancer development remains unexplored. Here we demonstrate that tumor-generating, fibroblast-like cells isolated from 3-methylcholanthrene (3MC)-induced murine tumor exhibit distinct phospho-dependent localization of NMIIA and NMIIB at the perinuclear area and tip of the filopodia and affect cell migration differentially. While NMIIA-KD affects protrusion dynamics and increases cell directionality, NMIIB-KD lowers migration speed and increases filopodial branching. Read More

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http://dx.doi.org/10.1091/mbc.E18-12-0790DOI Listing

Hybrid analysis of gene dynamics predicts context specific expression and offers regulatory insights.

Bioinformatics 2019 Apr 17. Epub 2019 Apr 17.

Interdisciplinary Biological Sciences, Northwestern University, Evanston, IL.

Motivation: To understand the regulatory pathways underlying diseases, studies often investigate the differential gene expression between genetically or chemically differing cell populations. Differential expression analysis identifies global changes in transcription and enables the inference of functional roles of applied perturbations. This approach has transformed the discovery of genetic drivers of disease and possible therapies. Read More

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http://dx.doi.org/10.1093/bioinformatics/btz256DOI Listing

Exploring the Insecticide and Acaricide Potential of Development Regulators obtained from Restinga vegetation from Brazil.

An Acad Bras Cienc 2019 8;91(1):e20180381. Epub 2019 Apr 8.

Laboratório de Estudos de Pragas e Parasitas, Departamento de Biologia Celular e Molecular, Universidade Federal Fluminense, Outeiro de São João Batista, s/n Centro, 24020 140 Niterói, RJ, Brazil.

As a part of our continuing search for insect and arthropod development regulators from Brazilian restinga vegetation of the Rio de Janeiro State, crude extracts, purified fractions and essential oils were submitted to screening tests seeking for biological activities on the development of the insects Rhodnius prolixus, Dysdercus peruvianus, Oncopeltus fasciatus and Rhipicephalus (Boophilus) microplus. Up to now, 102 secondary metabolites have been detected in the fractions, among them monoterpenes, sesquiterpenes and two triterpenes which were obtained from the species, Eugenia sulcata, Pilocarpus spicatus, Manilkara subsericea, Myrciaria floribunda and Zanthoxylum caribaeum. These secondary plant metabolites are considered of interest for the use of studies related to arthropod endocrinology, vector-parasite interaction system, and population control of vector insect and agricultural pest. Read More

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http://dx.doi.org/10.1590/0001-3765201920180381DOI Listing

Epigenetic Modulators as Potential Multi-targeted Drugs Against Hedgehog Pathway for Treatment of Cancer.

Protein J 2019 Apr 16. Epub 2019 Apr 16.

Symbiosis School of Biological Sciences, Symbiosis International (Deemed University), Gram-Lavale, Taluka-Mulshi, Pune, 412115, India.

The Sonic hedgehog signalling is known to play a crucial role in regulating embryonic development, cancer stem cell maintenance and tissue patterning. Dysregulated hedgehog signalling has been reported to affect tumorigenesis and drug response in various human malignancies. Epigenetic therapy relying on DNA methyltransferase and Histone deacetylase inhibitors are being proposed as potential drug candidates considering their efficiency in preventing development of cancer progenitor cells, killing drug resistant cells and also dictating "on/off" switch of tumor suppressor genes and oncogenes. Read More

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http://link.springer.com/10.1007/s10930-019-09832-9
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http://dx.doi.org/10.1007/s10930-019-09832-9DOI Listing
April 2019
2 Reads

Genome-Wide Identification of Long Non-coding RNAs Responsive to Infection in Grapevine.

Evol Bioinform Online 2019 4;15:1176934319841362. Epub 2019 Apr 4.

Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.

Long non-coding RNAs (lncRNAs) refer to a class of RNA molecules that are longer than 200 nucleotides and do not encode proteins. Numerous lncRNAs have recently emerged as important regulators of many biological processes in animals and plants, including responses to environmental stress and pathogens. dieback is one of the more severe grapevine trunk diseases worldwide. Read More

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http://dx.doi.org/10.1177/1176934319841362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449811PMC
April 2019
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Cooperation between T cell receptor and Toll-like receptor 5 signaling for CD4 T cell activation.

Sci Signal 2019 Apr 16;12(577). Epub 2019 Apr 16.

Computational System Biology Team, Institut de Biologie de l'Ecole Normale Supérieure, CNRS UMR8197, INSERM U1024, École Normale Supérieure, Université PSL, 75005 Paris, France.

CD4 T cells recognize antigens through their T cell receptors (TCRs); however, additional signals involving costimulatory receptors, for example, CD28, are required for proper T cell activation. Alternative costimulatory receptors have been proposed, including members of the Toll-like receptor (TLR) family, such as TLR5 and TLR2. To understand the molecular mechanism underlying a potential costimulatory role for TLR5, we generated detailed molecular maps and logical models for the TCR and TLR5 signaling pathways and a merged model for cross-interactions between the two pathways. Read More

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aar3
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http://dx.doi.org/10.1126/scisignal.aar3641DOI Listing
April 2019
1 Read