832 results match your criteria Journal of Autonomic Pharmacology[Journal]


Role of endothelium in ischaemia-induced myocardial dysfunction of isolated working hearts: cardioprotection by activation of adenosine A(2A) receptors.

J Auton Pharmacol 2001 Oct-Dec;21(5-6):263-71

Department of Pharmacology, Welsh School of Pharmacy, Cardiff University, Cathays Park, Cardiff CF10 3XF, UK.

1 This study aimed to determine the role of the vascular endothelium on recovery of contractile function following global low-flow ischaemia of guinea-pig isolated working hearts and the effects of adenosine analogues on this recovery. 2 Guinea-pig isolated spontaneously beating or paced working hearts were set up and coronary flow (CF), aortic output (AO) (as an index of cardiac function), heart rate (HR), left ventricular pressure (LVP) and dP/dt max recorded. The endothelium was either intact or removed by a blast of oxygen. Read More

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September 2002
4 Reads

Effects of restraint stress on responsiveness of atria and vas deferens in Sprague-Dawley rats.

J Auton Pharmacol 2001 Oct-Dec;21(5-6):255-61

Department of Pharmacology, University of Sydney, New South Wales 2006, Australia.

1 The effects of stress in rats were evaluated by measuring changes in body weight and in responsiveness to noradrenaline (NA) in the isolated vas deferens and atria after the animals had been exposed to restraint or restraint and isolation. 2 Animals which were subjected to restraint alone (1 h day-1 for 3, 7 or 28 days) had a significantly reduced rate of body weight gain. This effect was not potentiated by the additional stress of isolation. Read More

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September 2002
6 Reads

Modification of cardiovascular responses to adenosine A1 receptor stimulation in the posterior hypothalamus of anaesthetized rats by cAMP and by GABA(B) receptor blockade.

J Auton Pharmacol 2001 Oct-Dec;21(5-6):249-54

Departments of Pharmacology, College of Medicine, Hanyang University, 17 Haengdang-Dong, Sungdong-Gu, Seoul 133-791, South Korea.

1 Injection of N(6)-cyclohexyladenosine (CHA; 1, 5 and 10 nmol), an adenosine A1 receptor agonist, into the posterior hypothalamus of rats produced a dose-dependent decrease in blood pressure (BP) and heart rate (HR). 2 Pretreatment with 8-cyclopentyl-1,3-dimethylxanthine (CPDX; 50 nmol), an adenosine A1 receptor antagonist, blocked the depressor and bradycardic effects of CHA (10 nmol). 3 Pretreatment with 8-bromo-cyclic adenosine monophosphate (AMP) (10 nmol), a cAMP analogue, attenuated the depressor and bradycardic effect of CHA (10 nmol); 8-bromo-cyclic guanosine monophosphate (GMP) (10 nmol), a cGMP analogue, did not modify those effects of CHA. Read More

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September 2002
4 Reads

The minor population of M3-receptors mediate contraction of human detrusor muscle in vitro.

J Auton Pharmacol 2001 Oct-Dec;21(5-6):243-8

Department of Biomedical Science, University of Sheffield, UK.

1 The objective was to determine the role of muscarinic receptor subtypes in mediating contraction of the human detrusor smooth muscle in vitro. 2 Contractile responses of human detrusor muscle strips to carbachol were obtained in the absence and presence of a range of muscarinic antagonists (pirenzepine, methoctramine, 4-diphenylacetoxy-N-methyl piperidine methiodide (4-DAMP), tropicamide, oxybutynin and tolterodine). Affinity estimates (pKB values) were calculated for the antagonists and correlated with values at the cloned muscarinic receptor subtypes quoted in the literature. Read More

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September 2002
5 Reads

Adrenaline hypothesis: effect of formoterol on noradrenaline release.

J Auton Pharmacol 2001 Oct-Dec;21(5-6):237-42

Catecholamines Biology Research Laboratory, INSERM - Broussais Faculty of Medicine, 15 rue de l'Ecole de Médecine, 75006 Paris, France.

1 Originally, the so-called 'adrenaline hypothesis' related the release of noradrenaline (NA) to stimulation of presynaptic beta2-receptors in nerve endings; now it confers a possible role to adrenaline taken up then released by nerves endings. It represents a potentially useful therapeutic pathway. The present study aims to investigate the effects of formoterol, a highly selective beta2-adrenoceptor agonist. Read More

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September 2002
8 Reads

The comparison of vitamin C and vitamin E on the protein oxidation of diabetic rats.

J Auton Pharmacol 2001 Oct-Dec;21(5-6):231-6

Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul 156-756, Republic of Korea.

1 We measured the plasma glucose and the glycosylated haemoglobin at the time of sacrifice in streptozotocin-induced diabetic mellitus (DM) rats. 2 In diabetic rats, plasma glucose and glycosylated haemoglobin was increased as compared with normal rats, and vitamin E inhibited the increase of glycosylated haemoglobin level but vitamin C had no effect. 3 The peroxidized proteins and lipids from the diabetic organs such as liver or kidney were measured to assess the oxidative damage. Read More

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September 2002
3 Reads

Bladder instability: a re-appraisal of classical experimental approaches and development of new therapeutic strategies.

J Auton Pharmacol 2001 Oct-Dec;21(5-6):219-29

Department of Experimental and Applied Pharmacology, School of Pharmacy, University of Pavia, Viale Taramelli, 14, I-27100 Pavia, Italy.

1 Despite the growing social interest in human urinary tract disorders, the aetiology of detrusor instability remains poorly understood. Myogenic and neural impairment of detrusor activity caused by CNS or autonomic injuries can results in dysfunctions of normal voiding of the bladder such as urinary incontinence. 2 The contractility of human detrusor smooth muscle is critically dependent on acetylcholine-induced muscarinic receptor activation. Read More

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September 2002
4 Reads

Racemic salbutamol administration to guinea-pigs selectively augments airway smooth muscle responsiveness to cholinoceptor agonists.

J Auton Pharmacol 2001 Aug;21(4):211-7

Department of Pharmaceutical Sciences, University of the Sciences in Philadelphia, 600 South Forty-third Street, Philadelphia, PA 19104-4495, USA.

1. An aim of this study was to investigate whether continuous in vivo administration of a low dose of salbutamol to guinea-pigs alters the responsiveness of airway smooth muscle in vitro. 2. Read More

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August 2001
4 Reads

Contractile effects of tacrolimus in human and rat isolated renal arteries.

J Auton Pharmacol 2001 Aug;21(4):205-10

Department of Internal Medicine, University of Freiburg, Hugstetter Str. 55, D-79106 Freiburg, Germany.

1. We tested the vasoactive properties of the immunosuppressive drug FK 506 (tacrolimus) in preconstricted rat and human isolated renal arteries in vitro. 2. Read More

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August 2001
3 Reads

The influences of extremely low frequency magnetic fields on clonidine-induced sleep in 2-day-old chicks.

J Auton Pharmacol 2001 Aug;21(4):197-203

Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul 156-756, Republic of Korea.

1. It has been shown that magnetic fields (MFs) affect a variety of biological effects in animal brains. There have been few experiments on the effects of MFs on sleep. Read More

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August 2001
5 Reads

The effects of adenosine on isolated right atrial preparations from streptozotocin-diabetic rats.

J Auton Pharmacol 2001 Aug;21(4):191-5

Department of Pharmacology, Akdeniz University Faculty of Medicine, Dekanlik binasi, 07070 Arapsuyu, Antalya, Turkey.

1. The aim of the present study was to investigate the inhibitory effects of adenosine on the contractile force and chronotropic action of isolated right atrial preparations from streptozotocin (STZ)-diabetic rats. 2. Read More

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August 2001
2 Reads

P2X(7) receptors in rat parotid acinar cells: formation of large pores.

J Auton Pharmacol 2001 Aug;21(4):181-90

Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.

1. Permeabilization of cells mediated by P2X(7) receptors occurs to varied degrees in native and heterologous expression systems. Previous studies on P2X(7) receptors in parotid acinar cells suggested that ATP does not permeabilize these cells. Read More

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August 2001
2 Reads

Effect of in vivo and in vitro ethanol on adrenergic and purinergic responses of the bisected rat vas deferens to low and high frequency pulses.

Authors:
C Boselli S Govoni

J Auton Pharmacol 2001 Aug;21(4):171-9

Department of Experimental and Applied Pharmacology, School of Pharmacy, University of Pavia, Viale Taramelli,14, 27100 Pavia, Italy.

1. This study investigates the effect of acute in vivo and in vitro ethanol administration on the contractions evoked electrically and by exogenous noradrenaline and alpha,beta-methylene-ATP in the rat bisected vas deferens. 2. Read More

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August 2001
5 Reads

A morpholinocatechol compound (UK42620) with clonidine- and tyramine-like actions.

J Auton Pharmacol 2001 Aug;21(4):165-9

Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia.

1. The actions of a morpholinocatechol (UK42620) were studied in rat isolated atria preparations consisting of spontaneously beating left and right atrial pairs. 2. Read More

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August 2001
2 Reads

Effects of reduced sympathetic activity on myocardial metaiodobenzylguanidine (MIBG) washout.

J Auton Pharmacol 2001 Jun;21(3):159-64

Department of Radiology, University of California, San Francisco, CA, USA.

1. Increase in myocardial sympathetic activity contributes markedly to the pathophysiology of conditions such as congestive heart failure and is also associated with myocardial infarction. However, measurement of myocardial sympathetic activity in vivo is difficult. Read More

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June 2001
2 Reads

Catecholamines in hyperpnoea-induced airway constriction of guinea pigs.

J Auton Pharmacol 2001 Jun;21(3):151-7

Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.

1. We found previously that propranolol augments hyperpnoea-induced bronchoconstriction (HIB). This study was performed to investigate the underlying mechanism of this aug- menting action of propranolol. Read More

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June 2001
2 Reads

Regarding the unitary theory of agonist and antagonist action at presynaptic adrenoceptors.

J Auton Pharmacol 2001 Jun;21(3):145-9

Department of Physiology and Pharmacology, CUNY Medical School/Sophie Davis School of Biomedical Education, City College of New York, New York City, NY 10031, USA.

1. The linkage between potentiation of field stimulation-induced noradrenaline release and blockade of the presynaptic inhibitory effect of exogenous noradrenaline by a presynaptic antagonist was examined in superfused rabbit aorta preparations. 2. Read More

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June 2001
2 Reads

Sensory neuropeptides are not involved in acetaldehyde-induced bronchoconstriction in guinea-pigs.

J Auton Pharmacol 2001 Jun;21(3):139-43

The Third Department of Internal Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa 920-8641, Japan.

1. Alcohol-induced asthma is characterized by worsening of asthmatic symptoms after alcohol ingestion. Acetaldehyde, a metabolite of ethanol, is thought to be a main factor of alcohol-induced asthma. Read More

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June 2001
2 Reads

Prostanoid release and constrictor responses to noradrenaline in the rat mesenteric vascular bed in non-insulin-dependent diabetes mellitus.

Authors:
H A Peredo

J Auton Pharmacol 2001 Jun;21(3):131-7

Instituto de Investigaciones Farmacológicas, CONICET, Buenos Aires, Argentina.

1. The administration of streptozotocin (STZ) to 2-day old rats induced a non-insulin-dependent diabetes mellitus (NIDDM)-like state, with mild hyperglycaemia and no alterations in body weight at the adult age. 2. Read More

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June 2001
2 Reads

Functional effects of dextran sulphate sodium (DSS) treatment on the longitudinal muscle of rat distal colon.

J Auton Pharmacol 2001 Jun;21(3):121-9

Department of Surgery, Institute of Surgical Sciences, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.

1. The current study addressed how acute colitis, induced in male Sprague-Dawley rats by the administration of dextran sulphate sodium (DSS) in their drinking water, may affect some functional properties of the longitudinal muscle layer of the distal colon. 2. Read More

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June 2001
2 Reads

Action of tacrine on muscarinic receptors in rat intestinal smooth muscle.

J Auton Pharmacol 2001 Apr;21(2):113-9

Departamento de Farmacología, Facultad de Farmacia, Universidad de Sevilla, Profesor García-Gonzalez s/n, 41012 Sevilla, Spain.

1. The reversible cholinesterase inhibitor, tacrine (THA) was examined against the contractions of rat duodenum to acetylcholine and carbachol (cholinesterase resistant). 2. Read More

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April 2001
4 Reads

Changes of the responses of single sympathetic ganglionic neurones to substance P following desensitization.

Authors:
M A Simmons

J Auton Pharmacol 2001 Apr;21(2):101-12

The Neuropharmacology Laboratory, Department of Pharmacology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, WV 25704, USA.

1. The neuropeptide substance P (SP) exerts an excitatory effect on sympathetic neurones by inhibiting a time- and voltage-dependent potassium current. During prolonged application of SP, the response desensitizes. Read More

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April 2001
2 Reads

Vascular inhibitory actions of 17beta-oestradiol in rat portal vein.

J Auton Pharmacol 2001 Apr;21(2):95-9

Department of Physiology, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

1. We have examined the effects of 17beta-oestradiol on spontaneous spikes and contractions to noradrenaline in rat portal vein. 2. Read More

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April 2001
2 Reads

Effects of P5, a novel oxazolo(3,2-a)pyridine derivative with a long-acting antihypertensive activity, on different agonist-mediated pressor responses in pithed rats.

J Auton Pharmacol 2001 Apr;21(2):85-93

Departamento de Fisiología y Farmacología, Laboratorio de Farmacognosia y Farmacología, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain.

1. An oxazolo(3,2-a)pyridine derivative P5, described chemically as (+/-)-ethyl-7-(3-nitrophenyl)-5,8a-dimethyl-6-methoxycarbonyl-2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridin-8-carboxylate, is a novel compound that has been synthesized as a possible antihypertensive prodrug of the 1,4-dihydropyridine type. Its antihypertensive activity was described in a previous study by the authors (Morán, Martin, Velasco, Martin, San Roman, Caballero, Puebla, Medarde & San Feliciano, 1997). Read More

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April 2001
2 Reads

Effects of natural tachykinins on ovine lower urinary tract smooth muscle.

J Auton Pharmacol 2001 Apr;21(2):79-84

Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, University of Rome 'La Sapienza', Ple Aldo Moro 5, 00185 Rome, Italy.

1. Numerous studies have demonstrated that the urinary bladder is particularly sensitive to tachykinins; rat, rabbit and guinea pig bladders, besides human detrusor, have been the most extensively studied, whereas very little is known about most large animal detrusors. The aim of this work was to study natural tachykinin activity on the lower urinary tract of ovine to make a comparison with data obtained in laboratory animals. Read More

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April 2001
3 Reads

Spontaneous baroreflex sensitivity as a dynamic measure of cardiac anticholinergic drug effect.

J Auton Pharmacol 2001 Apr;21(2):71-8

Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland.

1. In this study, the analysis of spontaneous baroreflex sensitivity (BRS) was applied to the dynamic assessment of cardiac anticholinergic drug effect in healthy male volunteers. 2. Read More

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April 2001
2 Reads

Adrenalectomy-induced potentiation of morphine action in guinea-pig ileum: possible decrease in the release of endogenous opioids from opioidergic neurones.

J Auton Pharmacol 2001 Apr;21(2):63-9

Department of Toxicology, Niigata College of Pharmacy, Niigata 950-2076, Japan.

1. The effects of adrenalectomy on exogenous and endogenous opioid actions in guinea-pig isolated myenteric plexus-longitudinal muscle (MPLM) were investigated. 2. Read More

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April 2001
2 Reads

Modulation of M-channel conductance by adenosine 5' triphosphate in bullfrog sympathetic B-neurones.

J Auton Pharmacol 2001 Feb;21(1):57-62

National Research Institute of Chinese Medicine, Pei-Tou, Taipei 122, Taiwan, ROC.

1. Adenosine 5' triphosphate (ATP) (0.5-500 microM) or muscarine (0. Read More

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February 2001
2 Reads

Presynaptic alpha2-adrenoceptor-mediated modulation of adenosine 5' triphosphate and noradrenaline corelease: differences in canine mesenteric artery and vein.

J Auton Pharmacol 2001 Feb;21(1):47-55

Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557-0046, USA.

1. The modulatory effects of agonists and antagonists of prejunctional alpha2-adrenoceptors on the electrical field stimulation (EFS, 0.3 ms, 12 V)-induced release of endogenous noradrenaline (NA) and the cotransmitter adenosine 5' triphosphate (ATP) were measured in endothelium-denuded segments of canine inferior mesenteric artery and compared with effects in mesenteric vein. Read More

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February 2001
2 Reads

Arrhythmogenesis in isolated rat hearts with enhanced alpha-adrenoceptor-mediated responsiveness.

J Auton Pharmacol 2001 Feb;21(1):39-45

Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.

1. It has been postulated that stimulation of myocardial alpha-adrenoceptors is one of the primary mediators of the dysrhythmias which occur during periods of myocardial ischaemia and reperfusion. This study examines arrhythmogenesis during coronary artery occlusion and reperfusion in isolated perfused rat hearts from control animals and from rats with enhanced myocardial alpha-adrenoceptor responsiveness. Read More

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February 2001
2 Reads

Activation of presynaptic A1-receptors by endogenous adenosine inhibits acetylcholine release in the guinea-pig ileum.

J Auton Pharmacol 2001 Feb;21(1):29-38

Biosciences Division, University of Hertfordshire, College Lane, Hatfield, Hertfordshire, UK.

1. It is well established that presynaptic adenosine A1-receptor activation inhibits acetylcholine (ACh) release in the guinea-pig ileum. The present study extends this observation and examines a possible role for endogenous adenosine in modulating cholinergic nerve function. Read More

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February 2001
2 Reads

The effects of thiol compounds and ebselen on nitric oxide activity in rat aortic vascular responses.

J Auton Pharmacol 2001 Feb;21(1):23-8

Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea SungKyunKwan University, Suwon 440-746, Korea.

1. Thiols have been implicated to play a role in a variety of aspects of nitric oxide (NO) generation and activity. Thiol dependence of nitric oxide synthase (NOS) has remained controversial and its mechanism is not clear. Read More

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February 2001
3 Reads

The effect of streptozotocin-induced diabetes on cardiac beta-adrenoceptor subtypes in the rat.

J Auton Pharmacol 2001 Feb;21(1):15-21

Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

1. The present study investigates the effect of short-term experimental diabetes of 14-days duration on the beta-adrenoceptor subtypes of the rat heart. 2 . Read More

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February 2001
3 Reads

Vascular responses to beta-adrenoceptor subtype-selective agonists with and without endothelium in rat common carotid arteries.

Authors:
S Chiba M Tsukada

J Auton Pharmacol 2001 Feb;21(1):7-13

Department of Pharmacology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.

1. Using the cannula inserting method, vasodilator responses to beta-adrenoceptor agonists (isoprenaline, denopamine and procaterol) were investigated in isolated and perfused rat common carotid arteries. 2. Read More

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February 2001
2 Reads

Methyl orange antagonizes uridine 5' triphosphate and not alpha,beta-methylene-adenosine 5' triphosphate-evoked depolarization of rat superior cervical ganglia.

Authors:
G P Connolly

J Auton Pharmacol 2001 Feb;21(1):1-5

Purine NeuroScience Laboratory, Chemical Pathology, Guy's, King's and St Thomas' Medical School, King's College London, London SE1 9RT, UK.

1. Compared with the effects of adenosine 5' triphosphate (ATP) on the nervous system, the actions of pyrimidine nucleosides and their 5'-nucleotides, such as uridine 5' triphosphate (UTP), have received less attention. In part, this is because there is a need for a selective antagonist for responses mediated by UTP-activated receptors. Read More

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February 2001
2 Reads

Dopamine receptor immunohistochemistry in the rat choroid plexus.

J Auton Pharmacol 2000 Oct-Dec;20(5-6):325-32

Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Università di Camerino, Camerino, Italy.

1. Earlier studies have demonstrated a high density of dopamine D1-like receptor binding in the choroid plexus by light microscope autoradiography, but the dopaminergic specificity of this binding was questioned. 2. Read More

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July 2001
3 Reads

Characterization of mechanisms involved in presynaptic inhibition of sympathetic pressor effects induced by some 5-HT1 receptor antagonists.

J Auton Pharmacol 2000 Oct-Dec;20(5-6):313-23

Laboratorio de Farmacognosia y Farmacología, Departamento de Fisiología y Farmacología, Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain.

1. In a previous study, we showed that the presynaptic inhibitory action of 5-hydroxytryptamine receptor agonists on sympathetic pressor effects obtained in the pithed rats were mainly mediated by activation of 5-HT1A and 5-HT1D receptor subtypes. At the time, we observed that some 5-HT1 receptors antagonists - WAY 100,635 and NAN-190 (both 5-HT1A receptor antagonists), methiothepin (a 5-HT1,2,5,6,7 receptor antagonist) and spiperone (a 5-HT1,2 receptor antagonist) - reduced per se the pressor effects obtained by electrical stimulation. Read More

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July 2001
3 Reads

In situ hybridization and immunocytochemistry of alpha1-adrenoceptors in human peripheral blood lymphocytes.

J Auton Pharmacol 2000 Oct-Dec;20(5-6):305-12

Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Università di Camerino, 62032 Camerino, Italy.

1 alpha1-Adrenoceptor subtypes were investigated in cytospin centrifuged preparations of human peripheral blood lymphocytes by in situ hybridization and immunocytochemistry. 2 In situ hybridization cytochemistry revealed alpha1A-, alpha1B-, and alpha1D-receptor mRNA in human peripheral blood lymphocytes. Lymphocytes hybridized for alpha1A receptor subtype represented approximately 30% of total lymphocytes, those hybridized for alpha1Beta- and alpha1D-receptor subtypes averaged 42 and 25% of total lymphocytes, respectively. Read More

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July 2001
4 Reads

Acute renal failure in 2K2C Goldblatt hypertensive rats during antihypertensive therapy: comparison of an angiotensin AT1 receptor antagonist and clonidine analogues.

J Auton Pharmacol 2000 Oct-Dec;20(5-6):297-304

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.

1. This study compared the effect of a non-peptide angiotensin II receptor antagonist and a series of clonidine analogues on blood pressure and renal function in a two-kidney two-clip Goldblatt rat model of hypertension subjected to 2 weeks of dietary sodium deprivation. 2. Read More

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July 2001
2 Reads

Comparison of IY81149 with omeprazole in rat reflux oesophagitis.

J Auton Pharmacol 2000 Oct-Dec;20(5-6):291-6

Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul 156-756, Republic of Korea.

1. This study was aimed at evaluating the effects of IY81149[2-[[(4methoxy-3-methyl)-2-pyridinyl]methylsulfinyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole], a new proton pump inhibitor, on the development of the surgically induced reflux oesophagitis, on gastric secretion and on lipid peroxidation which is a marker of oxidative stress. Omeprazole was used as a reference drug. Read More

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July 2001
4 Reads

SERCA function declines with age in adrenergic nerves from the superior cervical ganglion.

J Auton Pharmacol 2000 Oct-Dec;20(5-6):281-90

Department of Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.

1. Intracellular calcium is a universal second messenger integrating numerous cellular pathways. An age-related breakdown in the mechanisms controlling [Ca2+]i homeostasis could contribute to neuronal degeneration. Read More

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July 2001
2 Reads

Autoregulation of neurotransmitter release at autonomic nerve terminals: a questionable theory.

Authors:
S Kalsner

J Auton Pharmacol 2000 Oct-Dec;20(5-6):271-9

The City University of New York Medical School, The Sophie Davis School of Biomedical Education, Department of Physiology and Pharmacology, 138th Street and Convent Avenue, New York City, NY 10031, USA.

1. The evidence for feedback regulation of neurotransmitter release by means of autoreceptors is questioned. 2. Read More

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July 2001
2 Reads

Wall tension and contraction of the aorta in 6-month-old spontaneously hypertensive rats.

J Auton Pharmacol 2000 Aug;20(4):265-9

Faculty of Medicine, Institute of Pharmacology and Therapeutics, Porto, Portugal.

1. The present study aimed at comparing the influence of passive tension on the effect exerted by noradrenaline on the thoracic aorta of 6-month-old Wistar and spontaneously hypertensive rats (SHR). 2. Read More

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August 2000
2 Reads

Effects of extremely low frequency magnetic fields on pain thresholds in mice: roles of melatonin and opioids.

J Auton Pharmacol 2000 Aug;20(4):259-64

Department of Pharmacology, College of Pharmacy, Chung Ang University, Seoul, Republic of Korea.

1. We studied the effects of extremely low frequency (ELF, 60 Hz) magnetic fields (MFs) on pain thresholds using the hot plate test. The implication of opioid and benzodiazepine system in the MFs-induced alteration of pain thresholds was also studied. Read More

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August 2000
3 Reads

Functional identification of beta3-adrenoceptors in the guinea-pig ileum using the non-selective beta-adrenoceptor antagonist (+/-)-bupranolol.

J Auton Pharmacol 2000 Aug;20(4):253-8

Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi, Chiba, Japan.

1. To clarify whether there is a species difference or a tissue difference in beta3-adrenoceptors, the beta3-adrenoceptors mediating relaxations to catecholamines ((-)-isoprenaline, (-)-noradrenaline and (-)-adrenaline), a selective beta3-adrenoceptor agonist BRL37344 and a non-conventional partial beta3-adrenoceptor agonist (+/-)-CGP12177A (a potent beta1- and beta2-adrenoceptor antagonist with a partial beta3-adrenoceptor agonist property) were investigated in the guinea-pig ileum. 2. Read More

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August 2000
3 Reads

Influence of the epithelium on acetylcholine release from parasympathetic nerves of the rat trachea.

J Auton Pharmacol 2000 Aug;20(4):237-51

Department of Pharmacology, University of Melbourne, Parkville VIC, Australia.

1. The present study was undertaken to investigate the influence of the airway epithelium on the release of acetylcholine (ACh) from parasympathetic nerves of the rat trachea. Epithelium-intact and epithelium-denuded preparations of rat trachea were incubated with [3H]-choline to incorporate [3H]-ACh into the cholinergic transmitter stores. Read More

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August 2000
3 Reads

Inhibition of isolated rat and human detrusor muscle contraction by disopyramide.

J Auton Pharmacol 2000 Aug;20(4):229-36

University of Leicester, Division of Medicine for the Elderly, Leicester General Hospital, UK.

1. The aim of this study was to investigate the effect of in vitro and in vivo disopyramide treatment on human and rat isolated detrusor muscle contractile response. Muscle strips were suspended in an organ bath chamber containing Kreb's solution at 37 degrees C aerated with 95% oxygen and 5% carbon dioxide. Read More

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August 2000
4 Reads

The relative importance of the time-course of receptor occupancy and response decay on apparent antagonist potency in dynamic assays.

Authors:
M Corsi T Kenakin

J Auton Pharmacol 2000 Aug;20(4):221-7

Pharmacology Department, Glaxo Wellcome S.p.A., Verona, Italy.

1. The potency of the beta1-adrenoceptor antagonist atenolol was measured as an inhibitor of responses to isoprenaline in guinea-pig left atria. Measurements were made in two ways, firstly, by pre-incubating the atria with a given concentration of atenolol followed by an isoprenaline dose-response curve and, secondly, by measuring the response to isoprenaline followed by addition of atenolol. Read More

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August 2000
2 Reads

Potassium channels in gastrointestinal smooth muscle.

Authors:
F Vogalis

J Auton Pharmacol 2000 Aug;20(4):207-19

Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia.

1. Electromechanical coupling in smooth muscle serves to coordinate the contractile activity of the syncytium. Electrical activity of smooth muscle of the gut is generated by ionic conductances that regulate and in turn are regulated by the membrane potential of smooth muscle cells. Read More

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August 2000
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The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies.

J Auton Pharmacol 2000 Aug;20(4):193-206

Department of Pharmacology, Monash University, Vic, Australia.

1. We review literature demonstrating (a) the presence and (b) the actions of substances that mediate or modify neuroeffector transmission to the smooth muscle of the prostrate stroma of a number of species including man. 2. Read More

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August 2000
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