2,840 results match your criteria Journal of Autoimmunity [Journal]


Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients.

J Autoimmun 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. Electronic address:

Objectives: To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients.

Methods: Adult patients with confirmed IIM recruited to the EuroMyositis registry (n = 1637) from four centres were investigated for the presence of MSAs/MAAs by radiolabelled-immunoprecipitation, with confirmation of anti-MDA5 and anti-NXP2 by ELISA. Clinical associations for each autoantibody were calculated for 1483 patients with a single or no known autoantibody by global linear regression modelling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.04.001DOI Listing

Florid biliary duct lesions in an AMA -positive patient in absence of cholestatic liver biochemistry.

J Autoimmun 2019 Apr 8. Epub 2019 Apr 8.

Gastroenterology & Hepatology Department Hamad Medical Corporation, Qatar; Weill Cornell Medical College, Qatar Br, Qatar. Electronic address:

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease, diagnosed by the presence of anti-mitochondrial antibodies (AMA) or highly PBC-specific anti-nuclear antibodies, in the appropriate context of cholestatic liver biochemistry. We present a case with histological features of destructive granulomatous lymphocytic cholangitis affecting interlobular and septal bile ducts suggestive of PBC, with strong positive AMA, Anti-M2 and anti-nuclear dot, but with persistently normal alkaline phosphatase (ALP). On the contrary to previous reports suggesting that those individuals in whom ALP remains persistently below 1. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411193009
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2019.04.004DOI Listing
April 2019
3 Reads

Impaired Tip60-mediated Foxp3 acetylation attenuates regulatory T cell development in rheumatoid arthritis.

J Autoimmun 2019 Apr 3. Epub 2019 Apr 3.

(a)The Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, PR China. Electronic address:

In rheumatoid arthritis (RA), imbalanced T cells subsets play a critical role in sustaining chronic inflammatory responses in the synovium. Naïve T cells in RA patients undergo maldifferentiation, including an increase in the effector Th1/Th17 lineage and a reduction in regulatory T (Treg) cells. Upon stimulation, naïve CD4CD45RO T cells from RA patients exhibited insufficient expression of Foxp3, which induced a deficiency in Tregs production and an imbalance of Treg/Th17 differentiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.02.007DOI Listing
April 2019
2 Reads

Shared T cell receptor chains in blood memory CD4 T cells of narcolepsy type 1 patients.

J Autoimmun 2019 Apr 2. Epub 2019 Apr 2.

Centre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France. Electronic address:

Convergent evidence points to the involvement of T cells in the pathogenesis of narcolepsy type 1 (NT1). Here, we hypothesized that expanded disease-specific T cell clones could be detected in the blood of NT1 patients. We compared the TCR repertoire of circulating antigen-experienced CD4 and CD8 T cells from 13 recently diagnosed NT1 patients and 11 age-, sex-, and HLA-DQB1*06:02-matched healthy controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.03.010DOI Listing
April 2019
2 Reads

Neutrophil extracellular traps are associated with the pathogenesis of diffuse alveolar hemorrhage in murine lupus.

J Autoimmun 2019 Mar 28. Epub 2019 Mar 28.

Aix-Marseille Univ, INSERM, INRA, C2VN, Marseille, France; Department of Internal Medicine and Clinical Immunology CHU Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France.

Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of systemic lupus erythematosus (SLE) and systemic vasculitis. Although initially described to have antibacterial properties, increasing evidence suggests that neutrophil extracellular traps (NETs) have a detrimental role in both autoimmune diseases and acute lung injury. We investigated whether NETs could be detected in a murine model of pristane-induced lupus DAH and contribute to lung injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.03.009DOI Listing
March 2019
1 Read

Soluble siglec-5 is a novel salivary biomarker for primary Sjogren's syndrome.

J Autoimmun 2019 Mar 25. Epub 2019 Mar 25.

Division of Rheumatology, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Despite advances in the understanding of the pathogenesis, disease-specific biomarkers have not been included in the classification criteria for Primary Sjogren's syndrome (pSS). Based on a microarray of peripheral blood mononuclear cells (PBMCs) from patients with primary Sjogren's syndrome (pSS), we aimed to investigate whether soluble sialic acid-binding immunoglobulin-like lectin (siglec)-5 in saliva might be a biomarker for pSS. The concentration of siglec-5 in saliva and sera was determined by ELISA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.03.008DOI Listing
March 2019
2 Reads

Transcriptomic and proteomic analysis of iris tissue and aqueous humor in juvenile idiopathic arthritis-associated uveitis.

J Autoimmun 2019 Mar 15. Epub 2019 Mar 15.

Department of Ophthalmology and Ophtha-Lab at St. Franziskus-Hospital, Münster, Germany; Department of Ophthalmology, University of Duisburg-Essen, Essen, Germany.

Gene and protein expression profiles of iris biopsies, aqueous humor (AqH), and sera in patients with juvenile idiopathic arthritis-associated uveitis (JIAU) in comparison to control patients with primary open-angle glaucoma (POAG) and HLA-B27-positive acute anterior uveitis (AAU) were investigated. Via RNA Sequencing (RNA-Seq) and mass spectrometry-based protein expression analyses 136 genes and 56 proteins could be identified as being significantly differentially expressed (DE) between the JIAU and POAG group. Gene expression of different immunoglobulin (Ig) components as well as of the B cell-associated factors ID3, ID1, and EBF1 was significantly upregulated in the JIAU group as compared to POAG patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.03.004DOI Listing
March 2019
1 Read

Plcγ2/Tmem178 dependent pathway in myeloid cells modulates the pathogenesis of cytokine storm syndrome.

J Autoimmun 2019 Mar 15. Epub 2019 Mar 15.

Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, USA; Shriners Hospitals for Children, St. Louis, MO, USA. Electronic address:

Cytokine storm syndrome (CSS) is a life-threatening condition characterized by excessive activation of T cells and uncontrolled inflammation, mostly described in patients with familial hemophagocytic lymphohistiocytosis and certain systemic auto-inflammatory diseases, such as systemic juvenile idiopathic arthritis (sJIA). Defects in T cell cytotoxicity as a mechanism for uncontrolled inflammation following viral infections fail to represent the whole spectrum of CSS. Evidence implicates dysregulated innate immune responses, especially activation of monocytes and macrophages, in patients with CSS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.02.005DOI Listing
March 2019
1 Read

Elevated autoimmunity in residents living near abandoned uranium mine sites on the Navajo Nation.

J Autoimmun 2019 May 14;99:15-23. Epub 2019 Mar 14.

Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center School of Medicine, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address:

Specific autoantibodies were assessed among residents of the Navajo Nation in New Mexico chronically exposed to metal mixtures from uranium mine wastes and in drinking water supplies. Age and the extent of exposure to legacy waste from 100 abandoned uranium mine and mill sites were associated with antibodies to denatured DNA, previously known to be an early indicator of medication-induced autoimmunity. Surprisingly, autoantibodies to native DNA and/or chromatin were also linked to environmental exposure, specifically uranium consumption through drinking water for both men and women, while urinary arsenic was negatively associated with these autoantibodies in women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.01.006DOI Listing

Expansion of circulating extrafollicular helper T-like cells in patients with chronic graft-versus-host disease.

J Autoimmun 2019 Mar 13. Epub 2019 Mar 13.

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangdong, China. Electronic address:

Chronic graft-versus-host disease (cGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous studies have shown that T follicular helper cells (Tfh) contribute to immune pathology in cGVHD, but the function of extrafollicular helper T cells during cGVHD pathogenesis remains largely unknown. In the current study, we identified circulating extrafollicular helper T-like cells (CD44CD62LPSGL-1CD4, c-extrafollicular Th-like) in human peripheral blood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.03.006DOI Listing

cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model.

J Autoimmun 2019 Mar 11. Epub 2019 Mar 11.

Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou, Fujian, 350117, China. Electronic address:

TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause cellular accumulation of DNA that triggers autoimmune diseases including Aicardi-Goutieres Syndrome (AGS) and systemic lupus erythematosus (SLE). We created a lupus mouse model by engineering a D18 N mutation in the Trex1 gene which inactivates the enzyme and has been found in human patients with lupus-like disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.03.001DOI Listing
March 2019
1 Read
8.410 Impact Factor

The immune milieu of cholangiocarcinoma: From molecular pathogenesis to precision medicine.

J Autoimmun 2019 Mar 9. Epub 2019 Mar 9.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy; Division of Internal Medicine and Hepatology, Department of Gastroenterology, Humanitas Clinical and Research Center IRCCS, Rozzano (MI), Italy. Electronic address:

Cholangiocarcinoma (CCA) is a deadly cancer of the biliary epithelium with limited therapeutic options. It is a heterogeneous group of cancer that could develop at any level from the biliary tree and is currently classified into intrahepatic, perihilar and distal based on its anatomical location. With incidence and mortality rates currently increasing, it is now the second most common type of primary liver cancer and represents up to 3% of all gastrointestinal malignancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.03.007DOI Listing
March 2019
2 Reads

Successful treatment of extensive calcifications and acute pulmonary involvement in dermatomyositis with the Janus-Kinase inhibitor tofacitinib - A report of two cases.

J Autoimmun 2019 Mar 9. Epub 2019 Mar 9.

Department of Internal Medicine, Clinic for Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, Hugstetter Str. 55, 79106, Freiburg, Germany. Electronic address:

Introduction: Dermatomyositis (DM) can be complicated by calcinosis and interstitial lung disease (ILD). Calcinosis can be severely debilitating or life-threatening and to date there is no treatment with proven efficacy. In DM type I interferon contributes to pathophysiology by inducing the expression of proinflammatory cytokines and the JAK-STAT (signal transducer and activator of transcription) pathway may be involved in the regulation of mitochondrial calcium store release, a process potentially important for calcification in DM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.03.003DOI Listing
March 2019
1 Read

Inflammatory myopathy associated with PD-1 inhibitors.

J Autoimmun 2019 Mar 10. Epub 2019 Mar 10.

Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address:

Objective: To characterize the inflammatory myopathy associated with programmed cell death 1 inhibitors (PD-1 myopathy).

Methods: We studied 19 Japanese patients with PD-1 myopathy (13 men and 6 women, mean age 70 years), who were referred to Keio University. As control groups, we used 68 patients with anti-signal recognition particle antibodies, 51 patients with anti-aminoacyl transfer RNA synthetase antibodies and 460 healthy subjects. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411193003
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2019.03.005DOI Listing
March 2019
7 Reads
8.410 Impact Factor

AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells.

J Autoimmun 2019 Mar 7. Epub 2019 Mar 7.

Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address:

AS101 is an organotellurium compound with multifaceted immunoregulatory properties that is remarkable for its lack of toxicity. We tested the therapeutic effect of AS101 in experimental autoimmune uveitis (EAU), a model for human autoimmune uveitis. Unexpectedly, treatment with AS101 elicited Treg generation in vivo in otherwise unmanipulated mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.02.006DOI Listing

Immunological effects of vitamin D and their relations to autoimmunity.

J Autoimmun 2019 Mar 7. Epub 2019 Mar 7.

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44106, USA. Electronic address:

Vitamin D deficiency is an established risk factor for many autoimmune diseases and the anti-inflammatory properties of vitamin D underscore its potential therapeutic value for these diseases. However, results of vitamin D3 supplementation clinical trials have been varied. To understand the clinical heterogeneity, we reviewed the pre-clinical data on vitamin D activity in four common autoimmune diseases: multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD), in which patients are commonly maintained on oral vitamin D3 supplementation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411193003
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2019.03.002DOI Listing
March 2019
16 Reads

'RA and the microbiome: do host genetic factors provide the link?

J Autoimmun 2019 May 5;99:104-115. Epub 2019 Mar 5.

The Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK; Clinical Age Research Unit, Kings College Hospital Foundation Trust, London, UK.

Rheumatoid arthritis (RA) is a chronic autoimmune disease, characterised by painful synovium inflammation, bony erosions, immune activation and the circulation of autoantibodies. Despite recent advances in therapeutics enabling disease suppression, there is a considerable demand for alternative therapeutic strategies as well as optimising those available at present. The relatively low concordance rate between monozygotic twins, 20-30% contrasts with heritability estimates of ∼65%, indicating a substantive role of other risk factors in RA pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.02.004DOI Listing
May 2019
10 Reads

Endogenous double-stranded Alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis.

J Autoimmun 2019 Feb 27. Epub 2019 Feb 27.

Departments of Medicine, Vanderbilt University Medical Center, Nashville, TN 37212, USA; Departments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212, USA. Electronic address:

Various sensors that detect double-stranded RNA, presumably of viral origin, exist in eukaryotic cells and induce IFN-responses. Ongoing IFN-responses have also been documented in a variety of human autoimmune diseases including relapsing-remitting multiple sclerosis (RRMS) but their origins remain obscure. We find increased IFN-responses in leukocytes in relapsing-remitting multiple sclerosis at distinct stages of disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.02.003DOI Listing
February 2019
1 Read
8.410 Impact Factor

Oral administration of Domain-I of beta-2glycoprotein-I induces immunological tolerance in experimental murine antiphospholipid syndrome.

J Autoimmun 2019 May 20;99:98-103. Epub 2019 Feb 20.

The Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine Tel-Aviv University, Israel; Department of Medicine 'B' Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel. Electronic address:

It is well established that the humoral immunity in antiphospholipid syndrome (APS) is presented by circulating pathogenic anti-β2GPI autoantibodies targeting mainly domain I of the β2GPI protein, playing a major role in the disease pathogenesis. Previously, we have demonstrated that treatment of experimental APS mice with tolerogenic dendritic cells loaded with domain-I was more efficient in tolerance induction than with the whole molecule or domain-V. In the current study we had orally administered a domain-I derivative of the β2GPI molecule, as a new therapeutic approach to induce oral tolerance in this mouse model of APS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.02.002DOI Listing
May 2019
2 Reads

Primary immunodeficiency and autoimmunity: A comprehensive review.

J Autoimmun 2019 May 20;99:52-72. Epub 2019 Feb 20.

Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis, School of Medicine, Davis, CA, USA. Electronic address:

The primary immunodeficiency diseases (PIDs) include many genetic disorders that affect different components of the innate and adaptive responses. The number of distinct genetic PIDs has increased exponentially with improved methods of detection and advanced laboratory methodology. Patients with PIDs have an increased susceptibility to infectious diseases and non-infectious complications including allergies, malignancies and autoimmune diseases (ADs), the latter being the first manifestation of PIDs in several cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.01.011DOI Listing
May 2019
1 Read
8.410 Impact Factor

Counter-regulation of regulatory T cells by autoreactive CD8 T cells in rheumatoid arthritis.

J Autoimmun 2019 May 16;99:81-97. Epub 2019 Feb 16.

Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, 00161, Rome, Italy; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy; Istituto Pasteur - Fondazione Cenci Bolognetti, 00185, Rome, Italy. Electronic address:

The mechanisms whereby autoreactive T cells escape peripheral tolerance establishing thus autoimmune diseases in humans remain an unresolved question. Here, we demonstrate that autoreactive polyfunctional CD8 T cells recognizing self-antigens (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.02.001DOI Listing
May 2019
2 Reads
8.410 Impact Factor

Clinical significance and immunobiology of IL-21 in autoimmunity.

J Autoimmun 2019 May 14;99:1-14. Epub 2019 Feb 14.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, PR China. Electronic address:

Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the immune system, for example, by promoting proliferation and the development of Tfh and Th17 cells, balancing helper T cell subsets, inducing B cell generation and differentiation into plasma cells, and enhancing the production of immunoglobulin. These effects are mainly mediated by activation of the JAK/STAT, MAPK and PI3K pathways. Some IL-21 target genes, such as B lymphocyte induced maturation protein-1 (Blimp-1), suppressor of cytokine signaling (SOCS), CXCR5 and Bcl-6, play important roles in the immune response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.01.013DOI Listing
May 2019
1 Read
8.410 Impact Factor

Autophagy promotes aortic adventitial fibrosis via the IL-6/Jak1 signaling pathway in Takayasu's arteritis.

J Autoimmun 2019 May 11;99:39-47. Epub 2019 Feb 11.

Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Evidence-Based Medicine Center, Fudan University, China. Electronic address:

Background: Autophagy is a ubiquitous and evolutionarily conserved self-rescue process. Studies have shown that autophagy is involved in the pathogenesis of multiple diseases; however, whether autophagy is associated with the pathogenesis of Takayasu's arteritis (TA), a large vessel idiopathic inflammatory disease characterized by vascular fibrosis, remains unclear. Moreover, although IL-6 is believed to be a direct target for TA treatment, anti-IL-6 treatment could not block TA-associated fibrosis in some cases, which impairs the aortic function of patients and can result in death. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.01.010DOI Listing
May 2019
1 Read

Recruitment of CXCR3 T cells into injured tissues in adult IgA vasculitis patients correlates with disease activity.

J Autoimmun 2019 May 8;99:73-80. Epub 2019 Feb 8.

Paris Descartes University, Cochin Institute, CNRS UMR8104, INSERM U1016, Paris, France. Electronic address:

Objectives: Adult immunoglobulin A vasculitis (IgAV) is an immune complex small vessel vasculitis. So far, the involvement of T cells in this pathology has been poorly studied. The aim of this study was to analyze T-cell homeostasis as well as cytokine and chemokine concentrations in the blood and tissues of IgAV patients. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183065
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2019.01.012DOI Listing
May 2019
8 Reads

Ischemic stroke in giant-cell arteritis: French retrospective study.

J Autoimmun 2019 May 5;99:48-51. Epub 2019 Feb 5.

Service de Médecine Interne-DHU i2B, Hôpital Saint-Antoine, APHP, 75012, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, France. Electronic address:

Acute cerebrovascular ischemic events are a rare and severe complication of giant cell arteritis (GCA). We aimed to determine the prevalence of GCA-related stroke, the overall survival and the relapse-free survival in patients with GCA. A multicentric retrospective analysis was performed on 129 patients with GCA diagnosed between September 2010 and October 2018 in two University Hospitals. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183073
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2019.01.009DOI Listing
May 2019
12 Reads

Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker?

J Autoimmun 2019 May 30;99:33-38. Epub 2019 Jan 30.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China. Electronic address:

Background And Aims: The most highly directed and specific autoantibody in human immunopathology is the serologic hallmark of primary biliary cholangitis (PBC), antimitochondrial antibodies (AMAs). However the clinical significance of finding a positive AMA, with normal alkaline phosphatase (ALP) remains enigmatic.

Methods: We took advantage of 169 consecutive outpatients who were identified as having a positive AMA, but normal ALP levels between January 2012 and January 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.01.005DOI Listing
May 2019
3 Reads
8.410 Impact Factor

Neutrophil extracellular traps exert both pro- and anti-inflammatory actions in rheumatoid arthritis that are modulated by C1q and LL-37.

J Autoimmun 2019 Mar 28;98:122-131. Epub 2019 Jan 28.

University of Paris 13, Sorbonne Paris Cité, Bobigny, France; Inserm UMR 1125, Li2P, Bobigny, France. Electronic address:

Objective: Neutrophil extracellular traps (NET), produced by activated polymorphonuclear neutrophils (PMN), are supposed to play a role in the pathogenesis of rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease characterized by anti-citrullinated protein antibodies (ACPA). Indeed, NET contain citrullinated autoantigens and some RA autoantibodies recognize NET. However, the mechanisms by which NET trigger or perpetuate the inflammatory process in RA are hitherto not elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.01.003DOI Listing

The microbiome and immunodeficiencies: Lessons from rare diseases.

J Autoimmun 2019 Mar 28;98:132-148. Epub 2019 Jan 28.

CNR-IRGB, Milan Unit, 20133, Milan, Italy; Humanitas Clinical and Research Center IRCCS, Rozzano, 20089, Milan, Italy. Electronic address:

Primary immunodeficiencies (PIDs) are inherited disorders of the immune system, associated with a considerable increase in susceptibility to infections. PIDs can also predispose to malignancy, inflammation and autoimmunity. There is increasing awareness that some aspects of the immune dysregulation in PIDs may be linked to intestinal microbiota. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183064
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2019.01.008DOI Listing
March 2019
7 Reads

PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus.

J Autoimmun 2019 May 22;99:24-32. Epub 2019 Jan 22.

Cancer and Inflammation Program, National Cancer Institute, NIH, Frederick, MD 21720, USA. Electronic address:

Systematic Lupus Erythematosus (SLE) is an autoimmune syndrome of unclear etiology. While T and B cell abnormalities contribute to disease pathogenesis, recent work suggests that inflammatory M1-like macrophages also play a role. Previous work showed that the TLR2/1 agonist PAM3CSK4 (PAM3) could stimulate normal human monocytes to preferentially differentiate into immunosuppressive M2-like rather than inflammatory M1-like macrophages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462249PMC

The therapeutic potential of tuftsin-phosphorylcholine in giant cell arteritis.

J Autoimmun 2019 Mar 10;98:113-121. Epub 2019 Jan 10.

Unit of Rheumatology, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy; Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Tuftsin-PhosphorylCholine (TPC) is a novel bi-specific molecule which links tuftsin and phosphorylcholine. TPC has shown immunomodulatory activities in experimental mouse models of autoimmune diseases. We studied herein the effects of TPC ex vivo on both peripheral blood mononuclear cells (PBMCs) and temporal artery biopsies (TABs) obtained from patients with giant cell arteritis (GCA) and age-matched disease controls. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183054
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2019.01.002DOI Listing
March 2019
11 Reads

Gut microbiota in children and altered profiles in juvenile idiopathic arthritis.

J Autoimmun 2019 Mar 9;98:1-12. Epub 2019 Jan 9.

Rheumatology Unit, Anna Meyer Children's Hospital, University of Florence, Viale G. Pieraccini 24, 50139, Florence, Italy; Department of Neuroscience, Psychology, Drug Research and Child Health, Meyer Children's Hospital, University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy. Electronic address:

Microbial diversity plays a key role in the maintenance of intestinal homeostasis and in the development of the immune system in the gut mucosa. Maybe one of the most important function of our gut microbiota is the immune system education, in particular the discrimination of friends from foes that occurs during childhood. In addition to bacterial antigens, several metabolites of microbial origin have a crucial role in training of the immune system, such as Short Chain Fatty Acids (SCFAs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2019.01.001DOI Listing
March 2019
5 Reads
8.410 Impact Factor

Multi-faceted inhibition of dendritic cell function by CD4Foxp3 regulatory T cells.

J Autoimmun 2019 Mar 5;98:86-94. Epub 2019 Jan 5.

Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address:

CTLA-4 is required for CD4Foxp3 regulatory T (Treg) cell function, but its mode of action remains incompletely defined. Herein we generated Ctla-4Foxp3-Cre mice with Treg cells exclusively expressing a naturally occurring, ligand-independent isoform of CTLA-4 (liCTLA-4) that cannot interact with the costimulatory molecules CD80 and CD86. The mice did not exhibit any signs of effector T cell activation early in life, however, at 6 months of age they exhibited excessive T cell activation and inflammation in lungs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.12.002DOI Listing
March 2019
2 Reads

NF-kB signaling in myeloid cells mediates the pathogenesis of immune-mediated nephritis.

J Autoimmun 2019 Mar 3;98:33-43. Epub 2019 Jan 3.

Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA; Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. Electronic address:

Immune-mediated glomerulonephritis is a serious end organ pathology that commonly affects patients with systemic lupus erythematosus (SLE). A classic murine model used to study lupus nephritis (LN) is nephrotoxic serum nephritis (NTN), in which mice are passively transferred nephrotoxic antibodies. We have previously shown that macrophages are important in the pathogenesis of LN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426635PMC
March 2019
3 Reads

Prognosticating autoimmune encephalitis: A systematic review.

J Autoimmun 2019 Jan 26;96:24-34. Epub 2018 Oct 26.

Department of Neuroscience, Monash University, Melbourne, Australia; Department of Neurology, Melbourne Health, Melbourne, Australia; Department of Neurology, Alfred Health, Melbourne, Australia.

Objective: To perform a systematic review of the current scientific literature in order to identify variables associated with patient prognosis in autoimmune encephalitis.

Methods: We performed a systematic literature search using MEDLINE, Embase, PubMed and PsychInfo databases. We selected studies that explored the correlation between early clinical and paraclinical findings, and patient outcomes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183048
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2018.10.014DOI Listing
January 2019
3 Reads
8.410 Impact Factor

Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation.

J Autoimmun 2019 Mar 26;98:103-112. Epub 2018 Dec 26.

Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University, New Haven, CT, USA. Electronic address:

Women with antiphospholipid antibodies (aPL) are at high risk for pregnancy complications, such as preeclampsia. We previously demonstrated that aPL recognizing βGPI promote an extravillous trophoblast pro-inflammatory, anti-migratory and anti-angiogenic profile similar to that seen in preeclampsia. Since preeclampsia in the absence of aPL may have an underlying infectious element, women with aPL may be at increased risk for preeclampsia or other adverse outcomes if an infection is present. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.12.003DOI Listing
March 2019
1 Read

Crosstalk between tumor necrosis factor-alpha signaling and aryl hydrocarbon receptor signaling in nuclear factor -kappa B activation: A possible molecular mechanism underlying the reduced efficacy of TNF-inhibitors in rheumatoid arthritis by smoking.

J Autoimmun 2019 Mar 25;98:95-102. Epub 2018 Dec 25.

Rheumatology and Allergology, NHO Osaka Minami Medical Center, Kidohigasi-machi, Kawachinagano, Osaka, 586-8521, Japan; Clinical Research, NHO Osaka Minami Medical Center, Kidohigasi-machi, Kawachinagano, Osaka, 586-8521, Japan. Electronic address:

Objectives: To examine the influence of smoking on biologics treatment against different therapeutic targets, such as TNFα, IL-6, and T cell, in rheumatoid arthritis (RA) and elucidate the underlying molecular mechanism.

Methods: The association between drug-discontinuation due to poor therapeutic response and smoking status was analyzed individually in biologics against different therapeutic targets by a multivariable logistic regression analysis using the "NinJa" Registry, one of the largest cohorts of Japanese RA patients. In vitro enhancement of TNFα-induced NF-κB activation and subsequent proinflammatory cytokine production by cigarette chemical components was examined by RT-PCR, qPCR, ELISA, and western blotting using an immortalized rheumatoid synovial cell line, MH7A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.12.004DOI Listing
March 2019
3 Reads

Il-23/Th17 cell pathway: A promising target to alleviate thymic inflammation maintenance in myasthenia gravis.

J Autoimmun 2019 Mar 18;98:59-73. Epub 2018 Dec 18.

Sorbonne Université, Centre de Recherche en Myologie, Paris, France; INSERM UMRS 974, Paris, France; AIM, Institute of Myology, Paris, France; Inovarion, Paris, France. Electronic address:

IL-23/Th17 pathway has been identified to sustain inflammatory condition in several autoimmune diseases and therefore being targeted in various therapeutic and effective approaches. Patients affected with autoimmune myasthenia gravis exhibit a disease effector tissue, the thymus, that harbors ectopic germinal centers that sustain production of auto-antibodies, targeting proteins located in the neuromuscular junction, cause of the organ-specific chronic autoimmune disease. The present study aims to investigate the IL-23/Th17 cell pathway in the thymic inflammatory and pathogenic events. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183060
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2018.11.005DOI Listing
March 2019
16 Reads

Alopecia areata: A multifactorial autoimmune condition.

J Autoimmun 2019 Mar 15;98:74-85. Epub 2018 Dec 15.

Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences, University of the West of Scotland, 1 High Street, Paisley, PA1 2BE, UK. Electronic address:

Alopecia areata is an autoimmune disease that results in non-scarring hair loss, and it is clinically characterised by small patches of baldness on the scalp and/or around the body. It can later progress to total loss of scalp hair (Alopecia totalis) and/or total loss of all body hair (Alopecia universalis). The rapid rate of hair loss and disfiguration caused by the condition causes anxiety on patients and increases the risks of developing psychological and psychiatric complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.12.001DOI Listing
March 2019
5 Reads

Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy.

J Autoimmun 2019 Mar 7;98:44-58. Epub 2018 Dec 7.

University of Cambridge, School of Clinical Medicine, Cambridge, CB2 0QQ, UK. Electronic address:

The development of humoral autoimmunity following organ transplantation is increasingly recognised, but of uncertain significance. We examine whether autoimmunity contributes independently to allograft rejection. In a MHC class II-mismatched murine model of chronic humoral rejection, we report that effector antinuclear autoantibody responses were initiated upon graft-versus-host allorecognition of recipient B cells by donor CD4 T-cells transferred within heart allografts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.11.006DOI Listing
March 2019
3 Reads

Primary central nervous system vasculitis mimicking brain tumor: Comprehensive analysis of 13 cases from a single institutional cohort of 191 cases.

J Autoimmun 2019 Feb 24;97:22-28. Epub 2018 Oct 24.

Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

Objective: To describe the clinical, laboratory, and imaging features and course of patients with primary central nervous system vasculitis (PCNSV) presenting with an intracranial tumor-like mass (TLM).

Methods: We retrospectively studied a cohort of 191 consecutive patients with PCNSV seen at the Mayo Clinic, Rochester, MN over a 35-year period (1982-2017). 13/191 patients presented with a TLM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.10.001DOI Listing
February 2019
3 Reads

Viral hepatitis, inflammation, and cancer: A lesson for autoimmunity.

J Autoimmun 2018 Dec 26;95:58-68. Epub 2018 Oct 26.

Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Italy; Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy; Center for Life Nano Science, Istituto Italiano di Tecnologia, Rome, Italy. Electronic address:

In the present review, we analyzed the various overlapping and non-mutually exclusive mechanisms that intersect and form complex and highly flexible immunological networks allowing the defense against liver infections and tumors. Liver immunity results from the combination of the skills of systemic and local immune system(s) to sense and recognize pathogen or tumor antigens, to sensitize a wide range of innate and adaptive immune cells, and to clear the "invaders", through the establishment of a transient liver immunopathology state undergoing resolution/control of infections or tumors, and memory development. Then, a special emphasis is placed on discussing about the capacity of the immune system(s) to develop a state of chronic low-level immunopathology adapting through the intervention of simultaneous immunoregulatory mechanisms, when the liver is infected by highly mutable viruses (e. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183060
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2018.10.021DOI Listing
December 2018
15 Reads

The immunobiology of female predominance in primary biliary cholangitis.

J Autoimmun 2018 Dec 25;95:124-132. Epub 2018 Oct 25.

Division Gastroenterology and Center for Autoimmune Liver Diseases, San Gerardo Hospital, Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy. Electronic address:

Primary biliary cholangitis (PBC) is an autoimmune liver disease with a striking female preponderance. The mechanisms behind this predominance are still to be elucidated, although multiple theories have been postulated and investigated. Among the proposed involved factors, sex hormones have been the first to be studied, but unfortunately data have been inconclusive or conflicting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.10.015DOI Listing
December 2018
2 Reads

Molecular mimicry and autoimmunity.

J Autoimmun 2018 Dec 26;95:100-123. Epub 2018 Oct 26.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Electronic address:

Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecular mimicry is unlikely to be the only underlying mechanism for autoimmune responses; other factors such as breach in central tolerance, non-specific bystander activation, or persistent antigenic stimuli (amongst others) may also contribute to the development of autoimmune diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.10.012DOI Listing
December 2018
2 Reads
8.410 Impact Factor

Targeting interferon activity to dendritic cells enables in vivo tolerization and protection against EAE in mice.

J Autoimmun 2019 Feb 19;97:70-76. Epub 2018 Nov 19.

Cytokine Receptor Laboratory, VIB Medical Biotechnology Center, Ghent University, 9000, Ghent, Belgium; Orionis Biosciences, 9052, Gent, Belgium. Electronic address:

Type I Interferon (IFN) is widely used for multiple sclerosis (MS) treatment, but its side effects are limiting and its mechanism of action still unknown. Furthermore, 30-50% of MS patients are unresponsive, and IFN can even induce relapses. Fundamental understanding of the cellular target(s) of IFN will help to optimize treatments by reducing side effects and separating beneficial from detrimental effects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.10.010DOI Listing
February 2019
19 Reads

Cluster analysis of autoimmune rheumatic diseases based on autoantibodies. New insights for polyautoimmunity.

J Autoimmun 2019 Mar 17;98:24-32. Epub 2018 Nov 17.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Electronic address:

Autoimmune diseases (ADs) are a chronic and clinically heterogeneous group of diseases characterized by share common immunopathogenic mechanisms and risk factors (i.e., the autoimmune tautology), which explain the fact that one AD may coexist with others (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.11.002DOI Listing
March 2019
13 Reads
8.410 Impact Factor

A multi-epitope DNA vaccine enables a broad engagement of diabetogenic T cells for tolerance in Type 1 diabetes.

J Autoimmun 2019 Mar 17;98:13-23. Epub 2018 Nov 17.

Columbia Center for Translational Immunology, Department of Medicine and Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, NY, USA. Electronic address:

Type 1 diabetes (T1D) is caused by diabetogenic T cells that evaded tolerance mechanisms and react against multiple β-cell antigens. Antigen-specific therapy to reinstate tolerance (typically using a single β-cell antigen) has so far proved unsuccessful in T1D patients. Plasmid DNA (pDNA)-mediated expression of proinsulin has demonstrated transient protection in clinical trials, but long-lasting tolerance is yet to be achieved. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183052
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389442PMC
March 2019
13 Reads

Systemic lupus erythematosus: Diagnosis and clinical management.

J Autoimmun 2019 Jan 16;96:1-13. Epub 2018 Nov 16.

Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore, MD 21205, USA. Electronic address:

Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogenous, reflecting the complex mosaic of disrupted molecular pathways converging into the SLE clinical phenotype. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183052
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310637PMC
January 2019
20 Reads

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease.

J Autoimmun 2018 Dec 13;95:1-14. Epub 2018 Nov 13.

JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; JDRF/Wellcome Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, CB2 OXY, UK. Electronic address:

Susceptibility to multiple autoimmune diseases is associated with common gene polymorphisms influencing IL-2 signaling and T function, making T-specific expansion by IL-2 a compelling therapeutic approach to treatment. As an in vivo IL-2 half-life enhancer we used a non-targeted, effector-function-silent human IgG1 as a fusion protein. An IL-2 mutein (N88D) with reduced binding to the intermediate affinity IL-2Rβγ receptor was engineered with a stoichiometry of two IL-2N88D molecules per IgG, i. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183042
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284106PMC
December 2018
30 Reads
8.410 Impact Factor

Prognostic models in primary biliary cholangitis.

J Autoimmun 2018 Dec 9;95:171-178. Epub 2018 Nov 9.

Division of Gastroenterology, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy; Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom. Electronic address:

Risk prediction modelling is important to better understand the determinants of the course and outcome of PBC and to inform the risk across the disease continuum in PBC enabling risk-stratified follow-up care and personalised therapy. Current prognostic models in PBC are based on treatment response to ursodeoxycholic acid because of the well-established relationship between alkaline phosphatase on treatment and long-term outcome. In addition, serum alkaline phosphatase correlates with ductular reaction and biliary metaplasia, which are hallmark of biliary injury. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08968411183062
Publisher Site
http://dx.doi.org/10.1016/j.jaut.2018.10.024DOI Listing
December 2018
15 Reads

Changes in the composition of the upper respiratory tract microbial community in granulomatosis with polyangiitis.

J Autoimmun 2019 Feb 9;97:29-39. Epub 2018 Nov 9.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Arnold-Heller-Strasse 3, Haus 27, 24105, Kiel, Germany. Electronic address:

Dysbiosis¸ i.e. changes in microbial composition at a mucosal interface, is implicated in the pathogenesis of many chronic inflammatory and autoimmune diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2018.10.005DOI Listing
February 2019
4 Reads