2,820 results match your criteria Journal of Autoimmunity [Journal]


Counter-regulation of regulatory T cells by autoreactive CD8 T cells in rheumatoid arthritis.

J Autoimmun 2019 Feb 16. Epub 2019 Feb 16.

Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, 00161, Rome, Italy; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy; Istituto Pasteur - Fondazione Cenci Bolognetti, 00185, Rome, Italy. Electronic address:

The mechanisms whereby autoreactive T cells escape peripheral tolerance establishing thus autoimmune diseases in humans remain an unresolved question. Here, we demonstrate that autoreactive polyfunctional CD8 T cells recognizing self-antigens (i.e. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.02.001DOI Listing
February 2019

Clinical significance and immunobiology of IL-21 in autoimmunity.

J Autoimmun 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, PR China. Electronic address:

Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the immune system, for example, by promoting proliferation and the development of Tfh and Th17 cells, balancing helper T cell subsets, inducing B cell generation and differentiation into plasma cells, and enhancing the production of immunoglobulin. These effects are mainly mediated by activation of the JAK/STAT, MAPK and PI3K pathways. Some IL-21 target genes, such as B lymphocyte induced maturation protein-1 (Blimp-1), suppressor of cytokine signaling (SOCS), CXCR5 and Bcl-6, play important roles in the immune response. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.013DOI Listing
February 2019
1 Read

Autophagy promotes aortic adventitial fibrosis via the IL-6/Jak1 signaling pathway in Takayasu's arteritis.

J Autoimmun 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; Evidence-Based Medicine Center, Fudan University, China. Electronic address:

Background: Autophagy is a ubiquitous and evolutionarily conserved self-rescue process. Studies have shown that autophagy is involved in the pathogenesis of multiple diseases; however, whether autophagy is associated with the pathogenesis of Takayasu's arteritis (TA), a large vessel idiopathic inflammatory disease characterized by vascular fibrosis, remains unclear. Moreover, although IL-6 is believed to be a direct target for TA treatment, anti-IL-6 treatment could not block TA-associated fibrosis in some cases, which impairs the aortic function of patients and can result in death. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.010DOI Listing
February 2019

Recruitment of CXCR3 T cells into injured tissues in adult IgA vasculitis patients correlates with disease activity.

J Autoimmun 2019 Feb 8. Epub 2019 Feb 8.

Paris Descartes University, Cochin Institute, CNRS UMR8104, INSERM U1016, Paris, France. Electronic address:

Objectives: Adult immunoglobulin A vasculitis (IgAV) is an immune complex small vessel vasculitis. So far, the involvement of T cells in this pathology has been poorly studied. The aim of this study was to analyze T-cell homeostasis as well as cytokine and chemokine concentrations in the blood and tissues of IgAV patients. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.012DOI Listing
February 2019
4 Reads

Ischemic stroke in giant-cell arteritis: French retrospective study.

J Autoimmun 2019 Feb 5. Epub 2019 Feb 5.

Service de Médecine Interne-DHU i2B, Hôpital Saint-Antoine, APHP, 75012, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, France. Electronic address:

Acute cerebrovascular ischemic events are a rare and severe complication of giant cell arteritis (GCA). We aimed to determine the prevalence of GCA-related stroke, the overall survival and the relapse-free survival in patients with GCA. A multicentric retrospective analysis was performed on 129 patients with GCA diagnosed between September 2010 and October 2018 in two University Hospitals. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.009DOI Listing
February 2019
4 Reads

Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker?

J Autoimmun 2019 Jan 29. Epub 2019 Jan 29.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China. Electronic address:

Background And Aims: The most highly directed and specific autoantibody in human immunopathology is the serologic hallmark of primary biliary cholangitis (PBC), antimitochondrial antibodies (AMAs). However the clinical significance of finding a positive AMA, with normal alkaline phosphatase (ALP) remains enigmatic.

Methods: We took advantage of 169 consecutive outpatients who were identified as having a positive AMA, but normal ALP levels between January 2012 and January 2018. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.005DOI Listing
January 2019
1 Read

Neutrophil extracellular traps exert both pro- and anti-inflammatory actions in rheumatoid arthritis that are modulated by C1q and LL-37.

J Autoimmun 2019 Jan 28. Epub 2019 Jan 28.

University of Paris 13, Sorbonne Paris Cité, Bobigny, France; Inserm UMR 1125, Li2P, Bobigny, France. Electronic address:

Objective: Neutrophil extracellular traps (NET), produced by activated polymorphonuclear neutrophils (PMN), are supposed to play a role in the pathogenesis of rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease characterized by anti-citrullinated protein antibodies (ACPA). Indeed, NET contain citrullinated autoantigens and some RA autoantibodies recognize NET. However, the mechanisms by which NET trigger or perpetuate the inflammatory process in RA are hitherto not elucidated. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.003DOI Listing
January 2019

The microbiome and immunodeficiencies: Lessons from rare diseases.

J Autoimmun 2019 Jan 28. Epub 2019 Jan 28.

CNR-IRGB, Milan Unit, 20133, Milan, Italy; Humanitas Clinical and Research Center IRCCS, Rozzano, 20089, Milan, Italy. Electronic address:

Primary immunodeficiencies (PIDs) are inherited disorders of the immune system, associated with a considerable increase in susceptibility to infections. PIDs can also predispose to malignancy, inflammation and autoimmunity. There is increasing awareness that some aspects of the immune dysregulation in PIDs may be linked to intestinal microbiota. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.008DOI Listing
January 2019
2 Reads

PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus.

J Autoimmun 2019 Jan 22. Epub 2019 Jan 22.

Cancer and Inflammation Program, National Cancer Institute, NIH, Frederick, MD 21720, USA. Electronic address:

Systematic Lupus Erythematosus (SLE) is an autoimmune syndrome of unclear etiology. While T and B cell abnormalities contribute to disease pathogenesis, recent work suggests that inflammatory M1-like macrophages also play a role. Previous work showed that the TLR2/1 agonist PAM3CSK4 (PAM3) could stimulate normal human monocytes to preferentially differentiate into immunosuppressive M2-like rather than inflammatory M1-like macrophages. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.004DOI Listing
January 2019

The therapeutic potential of tuftsin-phosphorylcholine in giant cell arteritis.

J Autoimmun 2019 Jan 9. Epub 2019 Jan 9.

Unit of Rheumatology, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy; Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Tuftsin-PhosphorylCholine (TPC) is a novel bi-specific molecule which links tuftsin and phosphorylcholine. TPC has shown immunomodulatory activities in experimental mouse models of autoimmune diseases. We studied herein the effects of TPC ex vivo on both peripheral blood mononuclear cells (PBMCs) and temporal artery biopsies (TABs) obtained from patients with giant cell arteritis (GCA) and age-matched disease controls. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.002DOI Listing
January 2019
5 Reads

Gut microbiota in children and altered profiles in juvenile idiopathic arthritis.

J Autoimmun 2019 Jan 9. Epub 2019 Jan 9.

Rheumatology Unit, Anna Meyer Children's Hospital, University of Florence, Viale G. Pieraccini 24, 50139, Florence, Italy; Department of Neuroscience, Psychology, Drug Research and Child Health, Meyer Children's Hospital, University of Florence, Viale G. Pieraccini 6, 50139, Florence, Italy. Electronic address:

Microbial diversity plays a key role in the maintenance of intestinal homeostasis and in the development of the immune system in the gut mucosa. Maybe one of the most important function of our gut microbiota is the immune system education, in particular the discrimination of friends from foes that occurs during childhood. In addition to bacterial antigens, several metabolites of microbial origin have a crucial role in training of the immune system, such as Short Chain Fatty Acids (SCFAs). Read More

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http://dx.doi.org/10.1016/j.jaut.2019.01.001DOI Listing
January 2019
8.410 Impact Factor

Multi-faceted inhibition of dendritic cell function by CD4Foxp3 regulatory T cells.

J Autoimmun 2019 Jan 4. Epub 2019 Jan 4.

Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address:

CTLA-4 is required for CD4Foxp3 regulatory T (Treg) cell function, but its mode of action remains incompletely defined. Herein we generated Ctla-4Foxp3-Cre mice with Treg cells exclusively expressing a naturally occurring, ligand-independent isoform of CTLA-4 (liCTLA-4) that cannot interact with the costimulatory molecules CD80 and CD86. The mice did not exhibit any signs of effector T cell activation early in life, however, at 6 months of age they exhibited excessive T cell activation and inflammation in lungs. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.12.002DOI Listing
January 2019

NF-kB signaling in myeloid cells mediates the pathogenesis of immune-mediated nephritis.

J Autoimmun 2019 Jan 3. Epub 2019 Jan 3.

Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA; Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. Electronic address:

Immune-mediated glomerulonephritis is a serious end organ pathology that commonly affects patients with systemic lupus erythematosus (SLE). A classic murine model used to study lupus nephritis (LN) is nephrotoxic serum nephritis (NTN), in which mice are passively transferred nephrotoxic antibodies. We have previously shown that macrophages are important in the pathogenesis of LN. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.11.004DOI Listing
January 2019
2 Reads

Prognosticating autoimmune encephalitis: A systematic review.

J Autoimmun 2019 Jan 26;96:24-34. Epub 2018 Oct 26.

Department of Neuroscience, Monash University, Melbourne, Australia; Department of Neurology, Melbourne Health, Melbourne, Australia; Department of Neurology, Alfred Health, Melbourne, Australia.

Objective: To perform a systematic review of the current scientific literature in order to identify variables associated with patient prognosis in autoimmune encephalitis.

Methods: We performed a systematic literature search using MEDLINE, Embase, PubMed and PsychInfo databases. We selected studies that explored the correlation between early clinical and paraclinical findings, and patient outcomes. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.014DOI Listing
January 2019
2 Reads

Role of NOD2 in antiphospholipid antibody-induced and bacterial MDP amplification of trophoblast inflammation.

J Autoimmun 2018 Dec 26. Epub 2018 Dec 26.

Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University, New Haven, CT, USA. Electronic address:

Women with antiphospholipid antibodies (aPL) are at high risk for pregnancy complications, such as preeclampsia. We previously demonstrated that aPL recognizing βGPI promote an extravillous trophoblast pro-inflammatory, anti-migratory and anti-angiogenic profile similar to that seen in preeclampsia. Since preeclampsia in the absence of aPL may have an underlying infectious element, women with aPL may be at increased risk for preeclampsia or other adverse outcomes if an infection is present. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.12.003DOI Listing
December 2018

Crosstalk between tumor necrosis factor-alpha signaling and aryl hydrocarbon receptor signaling in nuclear factor -kappa B activation: A possible molecular mechanism underlying the reduced efficacy of TNF-inhibitors in rheumatoid arthritis by smoking.

J Autoimmun 2018 Dec 24. Epub 2018 Dec 24.

Rheumatology and Allergology, NHO Osaka Minami Medical Center, Kidohigasi-machi, Kawachinagano, Osaka, 586-8521, Japan; Clinical Research, NHO Osaka Minami Medical Center, Kidohigasi-machi, Kawachinagano, Osaka, 586-8521, Japan. Electronic address:

Objectives: To examine the influence of smoking on biologics treatment against different therapeutic targets, such as TNFα, IL-6, and T cell, in rheumatoid arthritis (RA) and elucidate the underlying molecular mechanism.

Methods: The association between drug-discontinuation due to poor therapeutic response and smoking status was analyzed individually in biologics against different therapeutic targets by a multivariable logistic regression analysis using the "NinJa" Registry, one of the largest cohorts of Japanese RA patients. In vitro enhancement of TNFα-induced NF-κB activation and subsequent proinflammatory cytokine production by cigarette chemical components was examined by RT-PCR, qPCR, ELISA, and western blotting using an immortalized rheumatoid synovial cell line, MH7A. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.12.004DOI Listing
December 2018
3 Reads

Il-23/Th17 cell pathway: A promising target to alleviate thymic inflammation maintenance in myasthenia gravis.

J Autoimmun 2018 Dec 18. Epub 2018 Dec 18.

Sorbonne Université, Centre de Recherche en Myologie, Paris, France; INSERM UMRS 974, Paris, France; AIM, Institute of Myology, Paris, France; Inovarion, Paris, France. Electronic address:

IL-23/Th17 pathway has been identified to sustain inflammatory condition in several autoimmune diseases and therefore being targeted in various therapeutic and effective approaches. Patients affected with autoimmune myasthenia gravis exhibit a disease effector tissue, the thymus, that harbors ectopic germinal centers that sustain production of auto-antibodies, targeting proteins located in the neuromuscular junction, cause of the organ-specific chronic autoimmune disease. The present study aims to investigate the IL-23/Th17 cell pathway in the thymic inflammatory and pathogenic events. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.11.005DOI Listing
December 2018
10 Reads

Alopecia areata: A multifactorial autoimmune condition.

J Autoimmun 2018 Dec 15. Epub 2018 Dec 15.

Institute of Biomedical and Environmental Health Research, School of Health and Life Sciences, University of the West of Scotland, 1 High Street, Paisley, PA1 2BE, UK. Electronic address:

Alopecia areata is an autoimmune disease that results in non-scarring hair loss, and it is clinically characterised by small patches of baldness on the scalp and/or around the body. It can later progress to total loss of scalp hair (Alopecia totalis) and/or total loss of all body hair (Alopecia universalis). The rapid rate of hair loss and disfiguration caused by the condition causes anxiety on patients and increases the risks of developing psychological and psychiatric complications. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.12.001DOI Listing
December 2018
3 Reads

Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy.

J Autoimmun 2018 Dec 7. Epub 2018 Dec 7.

University of Cambridge, School of Clinical Medicine, Cambridge, CB2 0QQ, UK. Electronic address:

The development of humoral autoimmunity following organ transplantation is increasingly recognised, but of uncertain significance. We examine whether autoimmunity contributes independently to allograft rejection. In a MHC class II-mismatched murine model of chronic humoral rejection, we report that effector antinuclear autoantibody responses were initiated upon graft-versus-host allorecognition of recipient B cells by donor CD4 T-cells transferred within heart allografts. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.11.006DOI Listing
December 2018

Primary central nervous system vasculitis mimicking brain tumor: Comprehensive analysis of 13 cases from a single institutional cohort of 191 cases.

J Autoimmun 2019 Feb 24;97:22-28. Epub 2018 Oct 24.

Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.

Objective: To describe the clinical, laboratory, and imaging features and course of patients with primary central nervous system vasculitis (PCNSV) presenting with an intracranial tumor-like mass (TLM).

Methods: We retrospectively studied a cohort of 191 consecutive patients with PCNSV seen at the Mayo Clinic, Rochester, MN over a 35-year period (1982-2017). 13/191 patients presented with a TLM. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.001DOI Listing
February 2019
1 Read

Viral hepatitis, inflammation, and cancer: A lesson for autoimmunity.

J Autoimmun 2018 Dec 26;95:58-68. Epub 2018 Oct 26.

Dipartimento di Medicina Interna e Specialità Mediche, Sapienza University of Rome, Italy; Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy; Center for Life Nano Science, Istituto Italiano di Tecnologia, Rome, Italy. Electronic address:

In the present review, we analyzed the various overlapping and non-mutually exclusive mechanisms that intersect and form complex and highly flexible immunological networks allowing the defense against liver infections and tumors. Liver immunity results from the combination of the skills of systemic and local immune system(s) to sense and recognize pathogen or tumor antigens, to sensitize a wide range of innate and adaptive immune cells, and to clear the "invaders", through the establishment of a transient liver immunopathology state undergoing resolution/control of infections or tumors, and memory development. Then, a special emphasis is placed on discussing about the capacity of the immune system(s) to develop a state of chronic low-level immunopathology adapting through the intervention of simultaneous immunoregulatory mechanisms, when the liver is infected by highly mutable viruses (e. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.021DOI Listing
December 2018
9 Reads

The immunobiology of female predominance in primary biliary cholangitis.

J Autoimmun 2018 Dec 25;95:124-132. Epub 2018 Oct 25.

Division Gastroenterology and Center for Autoimmune Liver Diseases, San Gerardo Hospital, Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy. Electronic address:

Primary biliary cholangitis (PBC) is an autoimmune liver disease with a striking female preponderance. The mechanisms behind this predominance are still to be elucidated, although multiple theories have been postulated and investigated. Among the proposed involved factors, sex hormones have been the first to be studied, but unfortunately data have been inconclusive or conflicting. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.015DOI Listing
December 2018
1 Read

Molecular mimicry and autoimmunity.

J Autoimmun 2018 Dec 26;95:100-123. Epub 2018 Oct 26.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Electronic address:

Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecular mimicry is unlikely to be the only underlying mechanism for autoimmune responses; other factors such as breach in central tolerance, non-specific bystander activation, or persistent antigenic stimuli (amongst others) may also contribute to the development of autoimmune diseases. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.012DOI Listing
December 2018
8.410 Impact Factor

Targeting interferon activity to dendritic cells enables in vivo tolerization and protection against EAE in mice.

J Autoimmun 2019 Feb 19;97:70-76. Epub 2018 Nov 19.

Cytokine Receptor Laboratory, VIB Medical Biotechnology Center, Ghent University, 9000, Ghent, Belgium; Orionis Biosciences, 9052, Gent, Belgium. Electronic address:

Type I Interferon (IFN) is widely used for multiple sclerosis (MS) treatment, but its side effects are limiting and its mechanism of action still unknown. Furthermore, 30-50% of MS patients are unresponsive, and IFN can even induce relapses. Fundamental understanding of the cellular target(s) of IFN will help to optimize treatments by reducing side effects and separating beneficial from detrimental effects. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.010DOI Listing
February 2019
11 Reads

Cluster analysis of autoimmune rheumatic diseases based on autoantibodies. New insights for polyautoimmunity.

J Autoimmun 2018 Nov 17. Epub 2018 Nov 17.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Electronic address:

Autoimmune diseases (ADs) are a chronic and clinically heterogeneous group of diseases characterized by share common immunopathogenic mechanisms and risk factors (i.e., the autoimmune tautology), which explain the fact that one AD may coexist with others (i. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.11.002DOI Listing
November 2018
7 Reads
8.410 Impact Factor

A multi-epitope DNA vaccine enables a broad engagement of diabetogenic T cells for tolerance in Type 1 diabetes.

J Autoimmun 2018 Nov 17. Epub 2018 Nov 17.

Columbia Center for Translational Immunology, Department of Medicine and Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, NY, USA. Electronic address:

Type 1 diabetes (T1D) is caused by diabetogenic T cells that evaded tolerance mechanisms and react against multiple β-cell antigens. Antigen-specific therapy to reinstate tolerance (typically using a single β-cell antigen) has so far proved unsuccessful in T1D patients. Plasmid DNA (pDNA)-mediated expression of proinsulin has demonstrated transient protection in clinical trials, but long-lasting tolerance is yet to be achieved. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.11.003DOI Listing
November 2018
9 Reads

Systemic lupus erythematosus: Diagnosis and clinical management.

J Autoimmun 2019 Jan 16;96:1-13. Epub 2018 Nov 16.

Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore, MD 21205, USA. Electronic address:

Systemic lupus erythematosus (SLE) is a worldwide chronic autoimmune disease which may affect every organ and tissue. Genetic predisposition, environmental triggers, and the hormonal milieu, interplay in disease development and activity. Clinical manifestations and the pattern of organ involvement are widely heterogenous, reflecting the complex mosaic of disrupted molecular pathways converging into the SLE clinical phenotype. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310637PMC
January 2019
11 Reads

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease.

J Autoimmun 2018 Dec 13;95:1-14. Epub 2018 Nov 13.

JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; JDRF/Wellcome Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, CB2 OXY, UK. Electronic address:

Susceptibility to multiple autoimmune diseases is associated with common gene polymorphisms influencing IL-2 signaling and T function, making T-specific expansion by IL-2 a compelling therapeutic approach to treatment. As an in vivo IL-2 half-life enhancer we used a non-targeted, effector-function-silent human IgG1 as a fusion protein. An IL-2 mutein (N88D) with reduced binding to the intermediate affinity IL-2Rβγ receptor was engineered with a stoichiometry of two IL-2N88D molecules per IgG, i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183042
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http://dx.doi.org/10.1016/j.jaut.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284106PMC
December 2018
20 Reads
8.410 Impact Factor

Prognostic models in primary biliary cholangitis.

J Autoimmun 2018 Dec 9;95:171-178. Epub 2018 Nov 9.

Division of Gastroenterology, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy; Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom. Electronic address:

Risk prediction modelling is important to better understand the determinants of the course and outcome of PBC and to inform the risk across the disease continuum in PBC enabling risk-stratified follow-up care and personalised therapy. Current prognostic models in PBC are based on treatment response to ursodeoxycholic acid because of the well-established relationship between alkaline phosphatase on treatment and long-term outcome. In addition, serum alkaline phosphatase correlates with ductular reaction and biliary metaplasia, which are hallmark of biliary injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183062
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http://dx.doi.org/10.1016/j.jaut.2018.10.024DOI Listing
December 2018
9 Reads

Changes in the composition of the upper respiratory tract microbial community in granulomatosis with polyangiitis.

J Autoimmun 2019 Feb 9;97:29-39. Epub 2018 Nov 9.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Arnold-Heller-Strasse 3, Haus 27, 24105, Kiel, Germany. Electronic address:

Dysbiosis¸ i.e. changes in microbial composition at a mucosal interface, is implicated in the pathogenesis of many chronic inflammatory and autoimmune diseases. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.005DOI Listing
February 2019
2 Reads

Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus.

J Autoimmun 2019 Feb 9;97:77-87. Epub 2018 Nov 9.

Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

Objective: Alterations in the microbiota composition of the gastro-intestinal tract are suspected to be involved in the etiopathogenesis of two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE). Our objective was to assess whether alterations in gut and oral microbiota compositions are specific for pSS and SLE.

Methods: 16S ribosomal RNA gene sequencing was performed on fecal samples from 39 pSS patients, 30 SLE patients and 965 individuals from the general population, as well as on buccal swab and oral washing samples from the same pSS and SLE patients. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.009DOI Listing
February 2019
2 Reads

Novel mechanism for estrogen receptor alpha modulation of murine lupus.

J Autoimmun 2019 Feb 8;97:59-69. Epub 2018 Nov 8.

Medical University of South Carolina, Division of Rheumatology and Immunology, Charleston, SC, 29425, USA; Ralph H. Johnson Veterans Affairs Hospital, Charleston, SC, 29425, USA.

Female sex is a risk factor for lupus. Sex hormones, sex chromosomes and hormone receptors are implicated in the pathogenic pathways in lupus. Estrogen receptor alpha (ERα) knockout (KO) mice are used for defining hormone receptor effects in lupus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183051
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http://dx.doi.org/10.1016/j.jaut.2018.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351212PMC
February 2019
16 Reads

Novel therapeutic targets in autoimmune hepatitis.

J Autoimmun 2018 Dec 4;95:34-46. Epub 2018 Nov 4.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany; Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany. Electronic address:

Autoimmune hepatitis (AIH) is an orphan disease characterized by an autoimmune attack against hepatocytes. The exact sequence of events that leads to a breach of tolerance is incompletely understood. Current hypotheses suggest that environmental agents such as toxins or infectious agents like viruses cause a tissue damage that initiates autoimmunity in genetically susceptible individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183060
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http://dx.doi.org/10.1016/j.jaut.2018.10.022DOI Listing
December 2018
12 Reads

De novo autoimmune hepatitis -is this different in adults compared to children?

J Autoimmun 2018 Dec 3;95:26-33. Epub 2018 Nov 3.

Institute of Liver Studies, Mowat Labs, King's College Hospital, London, United Kingdom.

De novo autoimmune hepatitis (AIH) is an unusual cause of graft dysfunction after liver transplantation. This entity was originally described in 1996 in children transplanted for conditions other than AIH, who developed biochemical and histological features similar to AIH and responded to the therapy of classical AIH with steroids and azathioprine. In the last two decades, there have been reports of occurrence of de novo AIH in pediatric and adult liver transplant recipients, in the latter often being given different nomenclature including 'plasma cell hepatitis'. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183060
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http://dx.doi.org/10.1016/j.jaut.2018.10.023DOI Listing
December 2018
7 Reads

PD-1 immunobiology in systemic lupus erythematosus.

J Autoimmun 2019 Feb 3;97:1-9. Epub 2018 Nov 3.

Cancer Therapy Evaluation Program, Division of Cancer Treatment & Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Programmed death (PD)-1 receptors and their ligands have been identified in the pathogenesis and development of systemic lupus erythematosus (SLE). Two key pathways, toll-like receptor and type I interferon, are significant to SLE pathogenesis and modulate the expression of PD-1 and the ligands (PD-L1, PD-L2) through activation of NF-κB and/or STAT1. These cell signals are regulated by tyrosine kinase (Tyro, Axl, Mer) receptors (TAMs) that are aberrantly activated in SLE. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.025DOI Listing
February 2019
12 Reads

The utility of complement assays in clinical immunology: A comprehensive review.

J Autoimmun 2018 Dec 31;95:191-200. Epub 2018 Oct 31.

Labormedizinisches Zentrum Dr. Risch, Waldeggstrasse 37, CH-3097, Liebefeld bei Bern, Switzerland. Electronic address:

The multi-tasking organ liver, which is the major synthesis site of most serum proteins, supplies humoral components of the innate, - including proteins of the complement system; and, less intensely, also of the acquired immune system. In addition to hepatocyte origins, C1q, factor D, C3, C7 and other protein components of the complement system are produced at various body locations by monocytes/macrophages, lymphocytes, adipocytes, endometrium, enterocytes, keratinocytes and epithelial cells; but the contribution of these alternate sites to the total serum concentrations is slight. The two major exceptions are factor D, which cleaves factor B of the alternative pathway derived largely from adipocytes, and C7, derived largely from polymorphonuclear leukocytes and monocytes/macrophages. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183059
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http://dx.doi.org/10.1016/j.jaut.2018.10.013DOI Listing
December 2018
12 Reads

Identification of novel susceptibility genes associated with seven autoimmune disorders using whole genome molecular interaction networks.

J Autoimmun 2019 Feb 1;97:48-58. Epub 2018 Nov 1.

Radiation Oncology Department, Beaumont Health, 3811 W Thirteen Mile Road, Royal Oak, MI, 48073, USA. Electronic address:

Convergent evidence from multiple and independent genetics studies implicate a small number of genes that predispose individuals to multiple autoimmune disorders (AuD). These intersecting loci reinforced the hypothesis that disorders with overlapping etiology group into a cluster of closely related genes within a whole genome molecular interaction network. We tested the hypothesis that "biological network proximity" within a whole genome molecular interaction network can be used to inform the search for multigene inheritance. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.002DOI Listing
February 2019
5 Reads

Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjögren's syndrome patients.

J Autoimmun 2019 Feb 31;97:88-99. Epub 2018 Oct 31.

Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile. Electronic address:

Sjögren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity, which is fundamental for a correct function and localization of the secretory machinery. Syt-1, PI(4,5)P and Ca are significant factors controlling exocytosis in different secretory cells, the Ca role being the most studied. Salivary acinar cells from SS-patients show a defective agonist-regulated intracellular Ca release together with a decreased IP3R expression level, and this condition may explain a reduced water release. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.019DOI Listing
February 2019
3 Reads
8.410 Impact Factor

Etiopathogenesis of autoimmune hepatitis.

J Autoimmun 2018 Dec 29;95:133-143. Epub 2018 Oct 29.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

Autoimmune hepatitis is a chronic inflammatory liver disease characterized by hypergammaglobulinemia, the presence of autoantibodies, and inflammation within the liver, including lymphocytic infiltrates and interface hepatitis. Autoimmune hepatitis shows a female predominance and can present at any age and in any ethnicity. The disease is thought to be a consequence of a break of immune tolerance leading to an autoimmune process that induces liver injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183052
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http://dx.doi.org/10.1016/j.jaut.2018.10.020DOI Listing
December 2018
3 Reads
8.410 Impact Factor

The landscape and diagnostic potential of T and B cell repertoire in Immunoglobulin A Nephropathy.

J Autoimmun 2019 Feb 29;97:100-107. Epub 2018 Oct 29.

BGI-Shenzhen, Shenzhen 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China. Electronic address:

Immunoglobulin A Nephropathy (IgAN) is the most common glomerulonephritis worldwide. The pathologic hallmark of IgAN is immune complex deposited in glomerular mesangium, which induces inflammation and affects the kidney's normal functions. The exact pathogenesis of IgAN, however, remains obscure. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.018DOI Listing
February 2019
6 Reads
8.410 Impact Factor

The role of APRIL - A proliferation inducing ligand - In autoimmune diseases and expectations from its targeting.

J Autoimmun 2018 Dec 30;95:179-190. Epub 2018 Oct 30.

Institute for Advanced Biosciences, University Grenoble-Alpes, INSERM U1209, CNRS UMR 5309, La Tronche, 38700, France. Electronic address:

Autoimmunity occurs when an adaptive immune response is directed against a self-antigen. As such, autoimmune reactions associated with the production of autoantibodies are common. These autoantibodies may either be pathogenic by inducing the initial damage to self, or exacerbate the reaction secondarily to the initial damage. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183059
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http://dx.doi.org/10.1016/j.jaut.2018.10.016DOI Listing
December 2018
2 Reads

The clinical usage and definition of autoantibodies in immune-mediated liver disease: A comprehensive overview.

J Autoimmun 2018 Dec 23;95:144-158. Epub 2018 Oct 23.

Institute of Liver Studies, MowatLabs, King's College Hospital, Denmark Hill, London, SE5 9RS, UK. Electronic address:

Autoimmune serology is key to the diagnosis and management of autoimmune liver diseases. Its correct use in clinical practice requires a basic knowledge of the laboratory techniques used for autoantibody detection. Indirect immunofluorescence (IIF) on triple rodent tissue is still the gold standard screening procedure for liver-relevant autoantibodies, while HEp2 cells and human ethanol-fixed neutrophils are used as substrates to characterize nuclear reactivities and to detect anti-neutrophil cytoplasm antibody, respectively. Read More

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https://www.sciencedirect.com/journal/journal-of-autoimmunit
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https://linkinghub.elsevier.com/retrieve/pii/S08968411183051
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http://dx.doi.org/10.1016/j.jaut.2018.10.004DOI Listing
December 2018
15 Reads

Autoimmune sclerosing cholangitis: Evidence and open questions.

J Autoimmun 2018 Dec 23;95:15-25. Epub 2018 Oct 23.

Paediatric Liver, GI and Nutrition Centre, MowatLabs, King's College Hospital, London, UK.

Juvenile sclerosing cholangitis is a rare chronic hepatobiliary disorder characterized by inflammation of the intra- and/or extrahepatic bile ducts, bile duct dilatation, narrowing and obliteration, and, histologically, by inflammatory bile duct damage leading to periductular fibrosis. The diagnosis is based on endoscopic retrograde cholangiopancreatography or magnetic resonance cholangiopancreatography. In children, it may be associated to a variety of systemic and hepatic conditions: thus, the term "primary" sclerosing cholangitis should be reserved for the rare cases without a known cause. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183053
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http://dx.doi.org/10.1016/j.jaut.2018.10.008DOI Listing
December 2018
11 Reads

IgG Fc N-glycosylation: Alterations in neurologic diseases and potential therapeutic target?

J Autoimmun 2019 Jan 22;96:14-23. Epub 2018 Oct 22.

University Hospital Essen, University Duisburg-Essen, Germany.

Immunoglobulin G (IgG) is the most abundant antibody subclass of the human circulatory system and has important functions in the adaptive immune response. On the one hand, recognition and neutralization of antigens is mediated by the fab fragment, and on the other hand, processes such as phagocytosis, complement activation and inflammatory reactions are triggered by the Fc fragment. Here, the composition of conserved N-glycans attached to asparagine 297 of the IgG CH2 domain is a major critical factor that particularly modulates the effector functions of IgG. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.006DOI Listing
January 2019
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Juvenile autoimmune hepatitis: A comprehensive review.

J Autoimmun 2018 Dec 19;95:69-76. Epub 2018 Oct 19.

Paediatric Liver, GI & Nutrition Centre, MowatLabs, King's College Hospital, London, UK.

Autoimmune hepatitis (AIH) is a rare, chronic disease that affects both adults and children, including infants. The disease is probably triggered by environmental factors in genetically predisposed individuals. The clinical presentation ranges from asymptomatic patients or patients with non-specific symptoms, such as fatigue, to fulminant liver failure, many children presenting with symptoms indistinguishable from those of acute hepatitis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183057
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http://dx.doi.org/10.1016/j.jaut.2018.10.007DOI Listing
December 2018
14 Reads

Autoimmunity risk- and protection-associated IL7RA genetic variants differentially affect soluble and membrane IL-7Rα expression.

J Autoimmun 2019 Feb 17;97:40-47. Epub 2018 Oct 17.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Medical Faculty, 40225, Duesseldorf, Germany. Electronic address:

Interleukin-7 receptor α-chain (IL7RA) haplotypes are associated with susceptibility to autoimmune diseases including type 1 diabetes (T1D). Previous studies found lower soluble IL-7Rα (sIL-7Rα) serum levels of the protection-associated IL7RA haplotype assumed to reduce IL-7 availability for self-reactive T cells. Also, a risk-associated IL7RA haplotype is accompanied by lower sIL-7Rα serum concentrations but no underlying mechanisms have been described and the causative polymorphism remains unknown. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.10.003DOI Listing
February 2019

Gut microbiota translocation promotes autoimmune cholangitis.

J Autoimmun 2018 Dec 17;95:47-57. Epub 2018 Oct 17.

Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, China; Chronic Disease Laboratory, Institutes for Life Sciences and School of Medicine, South China University of Technology, Guangzhou, 510006, China; Liver Immunology Laboratory, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China. Electronic address:

Gut microbiota and bacterial translocation have been implicated as significant contributors to mucosal immune responses and tolerance; alteration of microbial molecules, termed pathogen-associated molecular patterns (PAMP) and bacterial translocation are associated with immune pathology. However, the mechanisms by which dysregulated gut microbiota promotes autoimmunity is unclear. We have taken advantage of a well-characterized murine model of primary biliary cholangitis, dnTGFβRII mice, and an additional unique construct, toll-like receptor 2 (TLR2)-deficient dnTGFβRII mice coined dnTGFβRIITLR2 mice to investigate the influences of gut microbiota on autoimmune cholangitis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183045
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http://dx.doi.org/10.1016/j.jaut.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290354PMC
December 2018
13 Reads

Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition.

J Autoimmun 2019 Jan 15;96:168-177. Epub 2018 Oct 15.

State Key Laboratory of Natural and Biomimetic Drugs & School of Pharmaceutical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing 100191, China. Electronic address:

Accumulating evidence has showed that anti-CASPR2 autoantibodies occur in a long list of neurological immune disorders including limbic encephalitis (LE). Belonging to the well-known neurexin superfamily, CASPR2 has been suggested to be a central node in the molecular networks controlling neurodevelopment. Distinct from other subfamilies in the neurexin superfamily, the CASPR subfamily features a unique discoidin (Disc) domain. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.09.012DOI Listing
January 2019
2 Reads
8.410 Impact Factor

Autoimmune liver disease serology in acute hepatitis E virus infection.

J Autoimmun 2018 Nov 7;94:1-6. Epub 2018 Jul 7.

DIMEC, University of Bologna, Bologna, Italy.

The etiology of autoimmune hepatitis (AIH) is unknown, though hepatotropic viruses may be potential triggers. Hepatitis E virus (HEV) infection, an increasingly recognized cause of acute hepatitis, has been misdiagnosed as AIH due to the occurrence of autoantibodies during its acute phase. It has also been suggested that HEV infection may lead to or unmask AIH. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183032
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http://dx.doi.org/10.1016/j.jaut.2018.07.006DOI Listing
November 2018
13 Reads
8.410 Impact Factor

White blood cell mitochondrial DNA copy number is decreased in rheumatoid arthritis and linked with risk factors. A twin study.

J Autoimmun 2019 Jan 14;96:142-146. Epub 2018 Oct 14.

Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Electronic address:

Low mitochondrial DNA copy number (mtDNA CN) has been associated with e.g. cancer, cardiovascular and autoimmune diseases. Read More

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http://dx.doi.org/10.1016/j.jaut.2018.09.008DOI Listing
January 2019
1 Read