34 results match your criteria Journal of Autoimmune Diseases[Journal]

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Cytochrome-P450 enzymes and autoimmunity: expansion of the relationship and introduction of free radicals as the link.

Authors:
M R Namazi

J Autoimmune Dis 2009 Jun 25;6. Epub 2009 Jun 25.

Medicinal and Natural Chemistry Products Research Center and Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran.

The Cytochrome-P-450 enzymes (CYP) are among the most important xenobiotic-metabolizing enzymes, which produce reactive oxygen species (ROS) as the result of metabolizing xenobiotics. ROS are believed to play important roles in the pathophysiology of autoimmune diseases. ROS can alter the structure of cellular antigens to produce a "neo-antigen" which could mount an autoimmune response against the original antigen through molecular mimicry. Read More

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https://jautoimdis.biomedcentral.com/articles/10.1186/1740-2
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http://dx.doi.org/10.1186/1740-2557-6-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708150PMC
June 2009
6 Reads

Antiphospholipid (Hughes) syndrome: beyond pregnancy morbidity and thrombosis.

J Autoimmune Dis 2009 May 19;6. Epub 2009 May 19.

The Lupus Research Unit, The Rayne Institute, 4thFloor, Lambeth Wing, St. Thomas' Hospital, London SE17EH, UK.

The antiphospholipid syndrome is an autoimmune disease characterised by recurrent arterial or venous thrombosis, pregnancy morbidity and the persistence of positive antiphospholipid antibodies. Many other clinical manifestations may occur including heart valve disease, livedo reticularis, thrombocytopenia and neurological manifestations such as migraine and seizures. We review a number of other manifestations including stenotic lesions, coronary artery disease and accelerated atherosclerosis, skeletal disorders and the concept of seronegative antiphospholipid syndrome. Read More

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http://dx.doi.org/10.1186/1740-2557-6-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689867PMC
May 2009
2 Reads

Prevalence of antibodies to Ro-52 in a serologically defined population of patients with systemic sclerosis.

J Autoimmune Dis 2009 Mar 6;6. Epub 2009 Mar 6.

Department of Clinical Immunology, Royal Free Hospital, London NW32QG, UK.

Background: Antibodies against Ro-52 have been described in patients with a broad spectrum of autoimmune disease, most commonly in association with anti-Ro-60 in systemic lupus erythematosus and Sjogrens syndrome. However, in inflammatory myositis anti-Ro-52 is frequently present without anti-Ro-60 and is closely linked to the presence of aminoacyl-tRNA synthetase (aats) antibodies. To date there have been no comprehensive reports on the frequency of anti-Ro-52 in systemic sclerosis (SSc), a disease characterised by hallmark autoantibodies that occur in non-overlapping subsets. Read More

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http://jautoimdis.biomedcentral.com/articles/10.1186/1740-25
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http://dx.doi.org/10.1186/1740-2557-6-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654555PMC
March 2009
8 Reads

Are classification criteria for vasculitis useful in clinical practice? Observations and lessons from Colombia.

J Autoimmune Dis 2009 Feb 27;6. Epub 2009 Feb 27.

Department of Internal Medicine, Rheumatology Unit, Universidad Nacional de Colombia, Bogota, Columbia.

Introduction: Idiopathic systemic vasculitis represents a group of clinical entities having non-specific etiology with the common characteristic of acute or chronic inflammatory compromise of the small and large vessels walls, associated with fibrinoid necrosis.

Objectives: To describe the most common inflammatory vascular diseases in a long historical cohort of patients from San Juan de Dios Hospital located in Bogota, Colombia using two different systems and a clinical histopathological correlation format, and to make a comparison between them.

Methods: We reviewed all previously ascertained cases of vasculitis confirmed by biopsy processed between 1953 and 1990, and systematically collected data on all new cases of vasculitis from 1991 to 1997 at the Hospital San Juan de Dios (Bogota-Colombia). Read More

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http://dx.doi.org/10.1186/1740-2557-6-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654892PMC
February 2009
12 Reads

Controversies in the antiphospholipid syndrome: can we ever stop warfarin?

J Autoimmune Dis 2008 Nov 11;5. Epub 2008 Nov 11.

The Lupus Research Unit, the Rayne Institute, St. Thomas' Hospital, London SE17EH, UK.

Patients with antiphospholipid syndrome are at increased risk for recurrent arterial and venous thrombosis and therefore benefit from long term warfarin therapy. The optimal duration of warfarin therapy after a first venous thromboembolic event is however a matter of some controversy and many questions remain unanswered. After reviewing and analysing the available evidence, we discuss some common scenarios in everyday clinical practice where treatment decisions are difficult. Read More

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http://jautoimdis.biomedcentral.com/articles/10.1186/1740-25
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http://dx.doi.org/10.1186/1740-2557-5-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632629PMC
November 2008
5 Reads

Autoantigenic nuclear proteins of a clinically atypical renal vasculitis.

J Autoimmune Dis 2008 Jul 14;5. Epub 2008 Jul 14.

Departamento de Bioquímica y Biología Molecular, Laboratorio de Biología del Desarrollo, Universidad de La Laguna, 38206 La Laguna, Tenerife, Spain.

Background: Systemic vasculitides constitute a heterogeneous group of diseases of autoimmunological origin characterized by inflammation of blood vessels and antibodies that react against autoantigens in a process that ultimately affects blood vessel walls. An important number of these patients present kidney disease. An endeavour of this area of research is the identification of autoantigens involved in these diseases. Read More

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http://dx.doi.org/10.1186/1740-2557-5-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483274PMC
July 2008
12 Reads

Association of Epstein-Barr virus antibody titers with a human IL-10 promoter polymorphism in Japanese women.

J Autoimmune Dis 2008 Mar 4;5. Epub 2008 Mar 4.

Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, AB, Canada.

Background: Multiple sclerosis (MS) risk, over 10-fold higher in Western than in Asian countries, is associated with elevated IgG antibody titers against Epstein-Barr viral capcid antigen (anti-EBVCA IgG titers). Given the 84% homology of the open reading frame BCRF1 of Epstein-Barr virus (EBV) to human interleukin 10 (hIL-10) and the remarkable Caucasian-vs.-Asian population differences in hIL-10 gene promoter polymorphisms, this strong association of MS risk with anti-EB-VCA IgG titers may be explained by the genetic variations in the hIL-10 gene. Read More

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http://dx.doi.org/10.1186/1740-2557-5-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292184PMC
March 2008
6 Reads

Immunogenetic mechanisms for the coexistence of organ-specific and systemic autoimmune diseases.

J Autoimmune Dis 2008 Feb 15;5. Epub 2008 Feb 15.

Department of Cancer Immunology & AIDS, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

Background: Organ-specific autoimmune diseases affect particular targets in the body, whereas systemic diseases engage multiple organs. Both types of autoimmune diseases may coexist in the same patient, either sequentially or concurrently, sustained by the presence of autoantibodies directed against the corresponding autoantigens. Multiple factors, including those of immunological, genetic, endocrine and environmental origin, contribute to the above condition. Read More

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http://dx.doi.org/10.1186/1740-2557-5-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265707PMC
February 2008
3 Reads

Islet cell autoantibodies in African patients with Type 1 and Type 2 diabetes in Dar es Salaam Tanzania: a cross sectional study.

J Autoimmune Dis 2007 Oct 27;4. Epub 2007 Oct 27.

Institute of Medicine, Division of Haraldsplass Deaconal Hospital, University of Bergen, Norway.

Background: The aim of the present study was to assess the occurrence of glutamic acid decarboxylase autoantibodies (GADA) and insulinoma antigen 2 autoantibodies (IA2A) among patients of African origin in Dar es Salaam, Tanzania and to compare the occurrence of autoimmune mediated Type 1 diabetes with findings previously reported from the same place and from other African diabetic populations.

Methods: Two hundred and forty five patients from the diabetic clinic at Muhimbili Hospital were recruited for a cross sectional study. Patients were clinically classified into groups with Type 1 (T1D) and Type 2 diabetes (T2D); there were 94 patients with T1D and 151 with T2D. Read More

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http://dx.doi.org/10.1186/1740-2557-4-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147002PMC
October 2007
4 Reads

The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders.

J Autoimmune Dis 2007 Jun 29;4. Epub 2007 Jun 29.

Dept. of Medicine, Research Laboratory of Internal Medicine, Medical School, University of Thessaly, 22 Papakiriazi str, Larissa 41222, Greece.

Background: We conducted a study in order to determine the usefulness and diagnostic value of International Autoimmune Hepatitis Group (IAHG) score in non-autoimmune hepatitis (AIH) hepatic disorders as well as in AIH/overlap syndromes and in cases with coexistence of AIH and other liver diseases.

Methods: We applied the IAHG score in 423 patients with liver diseases excluding patients with AIH, AIH/overlap syndromes and AIH with concurrent other liver disease namely, patients with chronic hepatitis B (n = 109), chronic hepatitis C (n = 95), chronic hepatitis D (n = 4), alchoholic liver disease (n = 28), non-alcoholic fatty liver disease (n = 55), autoimmune cholestatic liver diseases (n = 77), liver disorders of undefined origin (n = 32) and with miscellaneous hepatic disorders (n = 23). 24 patients with AIH associated with any kind of liver disorder including 10 patients with AIH/overlap syndromes and 14 AIH with concurrent other liver disease were also investigated. Read More

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http://dx.doi.org/10.1186/1740-2557-4-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933536PMC
June 2007
22 Reads

Autoimmune hepatitis-specific antibodies against soluble liver antigen and liver cytosol type 1 in patients with chronic viral hepatitis.

J Autoimmune Dis 2007 Feb 4;4. Epub 2007 Feb 4.

Department of Medicine, Academic Liver Unit and Research Laboratory of Internal Medicine, Larissa Medical School, University of Thessaly, Larissa, Greece.

Background: Non-organ specific autoantibodies are highly prevalent in patients with chronic hepatitis C (HCV). Among them, anti-liver kidney microsomal type 1 (LKM1) antibody--the serological marker of type 2 autoimmune hepatitis (AIH-2)--is detected in up to 11% of the HCV-infected subjects. On the other hand, anti-liver cytosol type 1 antibodies (anti-LC1)--either in association with anti-LKM1, or in isolation--and anti-soluble liver antigen antibodies (anti-SLA) have been considered as useful and specific diagnostic markers for AIH. Read More

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http://dx.doi.org/10.1186/1740-2557-4-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796878PMC
February 2007
20 Reads

Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome.

J Autoimmune Dis 2007 Jan 12;4. Epub 2007 Jan 12.

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, 11510 Puerto Real, Cádiz, Spain.

Background: Graham Little - Piccardi - Lassueur (GLPL) syndrome is a rare dermatosis characterized by scarring alopecia, loss of pubic and axillary hair, and progressive development of variously located follicular papules. We report a first case ever of an autoimmune response in a patient suffering from GLPL syndrome.

Methods: Immunofluorescence and immunoblot analysis were used in a variety of cell cultures including human, monkey, hamster, mouse and bovine cells to analyze the presence of autoantibodies in a GLPL patient. Read More

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http://dx.doi.org/10.1186/1740-2557-4-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783653PMC
January 2007
7 Reads

Decreased levels of metalloproteinase-9 and angiogenic factors in skin lesions of patients with psoriatic arthritis after therapy with anti-TNF-alpha.

J Autoimmune Dis 2006 Oct 5;3. Epub 2006 Oct 5.

Clinical Pathology and Microbiology Laboratory, San Gallicano Dermatology Institute, 00144 Rome, Italy.

Background: Inflammation represents an early and key event in the development of both the cutaneous psoriasis and psoriatic arthritis. Compelling evidences indicate that the production of TNF-alpha plays a central role in psoriasis by sustaining the inflammatory process in the skin as well as in the joints. Among the multiple effects produced by TNF-alpha on keratinocytes, the induction of matrix metalloproteinase-9 (MMP-9), a collagenase implicated in joint inflammatory arthritis which acts as an angiogenesis promoting factor, might represent a key mechanism in the pathogenesis of the disease. Read More

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http://jautoimdis.biomedcentral.com/articles/10.1186/1740-25
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http://dx.doi.org/10.1186/1740-2557-3-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1601955PMC
October 2006
23 Reads

Evaluation of antibodies against human HSP60 in patients with MPO-ANCA associated glomerulonephritis: a cohort study.

J Autoimmune Dis 2006 May 5;3. Epub 2006 May 5.

Dept, of Clinical and Experimental Immunology, University Hospital Maastricht, P,O, Box 5800, 6202 AZ Maastricht, The Netherlands.

Background: Human Heat Shock Protein 60 (hHSP60) has been implicated in autoimmunity through molecular mimicry, based on the high degree of homology with HSP65 of micro-organisms leading to autoimmune recognition of the human protein. Additionally, sequence homology between hHSP60 and myeloperoxidase (MPO) has been described. MPO is a major autoantigen in vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA). Read More

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http://dx.doi.org/10.1186/1740-2557-3-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526731PMC
May 2006
9 Reads

Cerebrovascular disease associated with antiphospholipid antibodies: more questions than answers.

J Autoimmune Dis 2006 Mar 30;3. Epub 2006 Mar 30.

Department of Clinical Immunology, The Canberra Hospital, Garran, Australia.

Neurological syndromes occur in a significant number of patients with antiphospholipid antibodies. The optimal management for these patients however remains uncertain. Our study is a descriptive analysis looking retrospectively at 45 patients who presented to the principal tertiary referral centre in the Australian Capital Territory, with either cerebral arterial or venous thrombosis for which there was no obvious cause for their presentation when initially reviewed. Read More

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http://dx.doi.org/10.1186/1740-2557-3-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448177PMC
March 2006
4 Reads

Endothelial cell activation and neovascularization are prominent in dermatomyositis.

J Autoimmune Dis 2006 Feb 20;3. Epub 2006 Feb 20.

Children's National Medical Center, Research Center for Genetic Medicine, 111 Michigan Ave NW, Washington, DC 20010, USA.

Background: While vascular and immune abnormalities are common in juvenile and adult dermatomyositis (DM), the molecular changes that contribute to these abnormalities are not clear. Therefore, we investigated pathways that facilitate new blood vessel formation and dendritic cell migration in dermatomyositis.

Methods: Muscle biopsies from subjects with DM (9 children and 6 adults) and non-myositis controls (6 children and 7 adults) were investigated by immunohistochemistry using antibodies that recognize existing (anti-CD146) and newly formed blood vessels (anti-alphaVbeta3) and mature dendritic cells (anti-DC-LAMP). Read More

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http://dx.doi.org/10.1186/1740-2557-3-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1397829PMC
February 2006
5 Reads

Virus-mediated autoimmunity in Multiple Sclerosis.

J Autoimmune Dis 2006 Feb 19;3. Epub 2006 Feb 19.

B' Department of Neurology, Laboratory of Experimental Neurology and Neuroimmunology, AHEPA University Hospital, 1 Stilp Kyriakidi Street, Aristotle University of Thessaloniki, Thessaloniki, 54636 Thessaloniki, Greece.

Epidemiological data suggest the notion that in Multiple Sclerosis (MS) is an acquired autoimmune disease and the cause may be an environmental factor(s), probably infectious, in genetically susceptible individuals. Several cases of viral induced demyelinatimg encephalomyelitis in human beings and in experimental models as well as the presence of IgG oligoclonal bands in the cerebrospinal fluid indicate that the infectious factor may be viral. However, the absence of a specific virus identification in MS central nervous system may hardly support this notion. Read More

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http://dx.doi.org/10.1186/1740-2557-3-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1397830PMC
February 2006
5 Reads

Phenytoin as a novel anti-vitiligo weapon.

Authors:
M R Namazi

J Autoimmune Dis 2005 Nov 22;2:11. Epub 2005 Nov 22.

Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran.

Vitiligo is a psychologically devastating clinical conundrum which affects approximately 1% of the general population. The exact cause of the illness is an enigma, but several hypotheses about its pathogenesis are advanced. The autoimmune hypothesis proposes an autoimmune attack against melanocytes. Read More

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http://dx.doi.org/10.1186/1740-2557-2-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308849PMC
November 2005
4 Reads

Autoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysis.

J Autoimmune Dis 2005 Nov 10;2:10. Epub 2005 Nov 10.

Departamento de Orientación Diagnóstica. Centro Nacional de Microbiologia. Instituto de Salud Carlos III. Ctra. Majadahonda -Pozuelo Km 12,5. 28080-Madrid. Spain.

Recent reports have shown that some of the immunological aspects of Q fever, a rickettsiosis caused by Coxiella burnetii, could be related to self-antigen responses. The aim of this study was to determine the specificity of the autoantibody response of patients with acute and chronic Coxiella infections. Smooth muscle and cardiac muscle-specific autoantibodies were observed in significant percentages in acutely or chronically affected Q fever patients when compared to healthy volunteers. Read More

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http://jautoimdis.biomedcentral.com/articles/10.1186/1740-25
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http://dx.doi.org/10.1186/1740-2557-2-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298324PMC
November 2005
3 Reads

Co-occurrence of autoimmune thyroid disease in a multiple sclerosis cohort.

J Autoimmune Dis 2005 Nov 9;2. Epub 2005 Nov 9.

Department of Neurology, Memorial University of Newfoundland, St John's, Canada.

Background: Multiple sclerosis (MS), Hashimoto's disease and Graves' disease are autoimmune diseases that may share similar pathogenic mechanisms. The co-occurrence rates and demographic characteristics of Graves' disease and Hashimoto's disease (HT) in our MS population are compared with the general population.

Methods: The prevalence of thyroid disease in our MS patients was determined by chart review and survey. Read More

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http://dx.doi.org/10.1186/1740-2557-2-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308850PMC
November 2005
2 Reads

Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes.

J Autoimmune Dis 2005 Oct 31;2. Epub 2005 Oct 31.

Center for Biotechnology and Genomic Medicine, Medical College of Georgia, CA4095 Augusta, GA 30912.

Background: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) plays a critical role in downregulation of antigen-activated immune response and polymorphisms at the CTLA-4 gene have been shown to be associated with several autoimmune diseases including type-1 diabetes (T1D). The etiological mutation was mapped to the CT60-A/G single nucleotide polymorphism (SNP) that is believed to control the processing and production of soluble CTLA-4 (sCTLA-4).

Methods: We therefore determined sCTLA-4 protein levels in the sera from 82 T1D patients and 19 autoantibody positive (AbP) subjects and 117 autoantibody negative (AbN) controls using ELISA. Read More

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http://jautoimdis.biomedcentral.com/articles/10.1186/1740-25
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http://dx.doi.org/10.1186/1740-2557-2-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1289290PMC
October 2005
7 Reads

Transfer of efficient anti-melanocyte T cells from vitiligo donors to melanoma patients as a novel immunotherapeutical strategy.

J Autoimmune Dis 2005 Aug 31;2. Epub 2005 Aug 31.

Experimental Immunology Laboratory, IRCCS Maugeri Foundation, Pavia, Italy.

Background: Vitiligo is a relatively common progressive depigmentary condition that is believed to be due to the autoimmune-mediated loss of epidermal melanocytes. High frequencies of self-reactive T lymphocytes directed toward melanocyte differentiation antigens are found in vitiligo patients and might be directly responsible for the pathogenesis of the disease. An interesting aspect of vitiligo is its relation to melanoma: cytotoxic T lymphocytes directed to self antigens shared by normal melanocytes and melanoma cells are found in both conditions, but the resulting immune reactions are completely different. Read More

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http://dx.doi.org/10.1186/1740-2557-2-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1215509PMC
August 2005
5 Reads

Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis.

J Autoimmune Dis 2005 Jun 28;2. Epub 2005 Jun 28.

Doheny Eye Institute, University of Southern California, Los Angeles, CA, USA.

Background: The most common cause of ocular morbidity in developed countries is dry eye, many cases of which are due to lacrimal insufficiency. Dry eye affects approximately 10 million in the United States, most of whom are women. In the U. Read More

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http://dx.doi.org/10.1186/1740-2557-2-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187915PMC
June 2005
9 Reads

Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome.

J Autoimmune Dis 2005 May 25;2. Epub 2005 May 25.

Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

People with chronic fatigue syndrome (CFS) suffer from multiple symptoms including fatigue, impaired memory and concentration, unrefreshing sleep and musculoskeletal pain. The exact causes of CFS are not known, but the symptom complex resembles that of several diseases that affect the immune system and autoantibodies may provide clues to the various etiologies of CFS. We used ELISA, immunoblot and commercially available assays to test serum from subjects enrolled in a physician-based surveillance study conducted in Atlanta, Georgia and a population-based study in Wichita, Kansas for a number of common autoantibodies and antibodies to neuron specific antigens. Read More

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http://dx.doi.org/10.1186/1740-2557-2-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1177983PMC
May 2005
4 Reads

N-acetyl-L-cysteine ameliorates the inflammatory disease process in experimental autoimmune encephalomyelitis in Lewis rats.

J Autoimmune Dis 2005 May 3;2(1). Epub 2005 May 3.

Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.

We report that N-acetyl-L-cysteine (NAC) treatment blocked induction of TNF-alpha, IL-1beta, IFN-gamma and iNOS in the CNS and attenuated clinical disease in the myelin basic protein induced model of experimental allergic encephalomyelitis (EAE) in Lewis rats. Infiltration of mononuclear cells into the CNS and induction of inflammatory cytokines and iNOS in multiple sclerosis (MS) and EAE have been implicated in subsequent disease progression and pathogenesis. To understand the mechanism of efficacy of NAC against EAE, we examined its effect on the production of cytokines and the infiltration of inflammatory cells into the CNS. Read More

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http://dx.doi.org/10.1186/1740-2557-2-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1097751PMC
May 2005
11 Reads

The importance of APC.

J Autoimmune Dis 2005 Apr 26;2(1). Epub 2005 Apr 26.

Department of Medicine, St, Luke's-Roosevelt Hospital Center, New York, NY, USA.

Readers in immunology are familiar with the importance of antigen presenting cells in mounting immune responses. For the purpose of this particular editorial article, however, the abbreviation APC will stand for article processing charges. The publisher will introduce APCs for this Journal in May, 2005. Read More

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http://dx.doi.org/10.1186/1740-2557-2-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087870PMC
April 2005
6 Reads

Localization of the immunodominant region on human thyroid peroxidase in autoimmune thyroid diseases: an update.

J Autoimmune Dis 2005 Mar 15;2(1). Epub 2005 Mar 15.

CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Santé, Faculté de Pharmacie, 15 avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France.

Recent studies in the field of autoimmune thyroid diseases have largely focused on the delineation of B-cell auto-epitopes recognized by the main autoantigens to improve our understanding of how these molecules are seen by the immune system. Among these autoantigens which are targeted by autoantibodies during the development of autoimmune thyroid diseases, thyroid peroxidase is a major player. Indeed, high amounts of anti-thyroid peroxidase autoantibodies are found in the sera of patients suffering from Graves' disease and Hashimoto's thyroiditis, respectively hyper and hypothyroidism. Read More

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http://dx.doi.org/10.1186/1740-2557-2-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084359PMC
March 2005
5 Reads

Immunogenetics of Hashimoto's thyroiditis.

J Autoimmune Dis 2005 Mar 11;2(1). Epub 2005 Mar 11.

Laboratory of Aquatic Ecology, Katholieke Universiteit Leuven, Ch, De Beriotstraat 32, B-3000 Leuven, Belgium.

Hashimoto's thyroiditis (HT) is an organ-specific T-cell mediated disease. It is a complex disease, with a strong genetic component. To date, significant progress has been made towards the identification and functional characterization of HT susceptibility genes. Read More

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http://dx.doi.org/10.1186/1740-2557-2-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC555850PMC
March 2005
3 Reads

Antibodies to soluble liver antigen and alpha-enolase in patients with autoimmune hepatitis.

J Autoimmune Dis 2004 Nov 19;1(1). Epub 2004 Nov 19.

Institute of Liver Studies, King's College Hospital, Denmark Hill, London SE5 9RS, UK.

BACKGROUND: Antibodies to a cytosolic soluble liver antigen (SLA) are specifically detected in patients with autoimmune hepatitis (AIH). The target of anti-SLA has been identified as a ~50 kDa UGA serine tRNA-associated protein complex (tRNP(Ser)Sec), through the screening of cDNA libraries. A recent report questioned the identity of tRNP(Ser)Sec as the real SLA antigen. Read More

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http://dx.doi.org/10.1186/1740-2557-1-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546408PMC
November 2004
6 Reads

Insulin expressing hepatocytes not destroyed in transgenic NOD mice.

J Autoimmune Dis 2004 Nov 8;1(1). Epub 2004 Nov 8.

Diabetes Transplant Unit, Prince of Wales Hospital, The University of New South Wales, Sydney, Australia.

BACKGROUND: The liver has been suggested as a suitable target organ for gene therapy of Type 1 diabetes. However, the fundamental issue whether insulin-secreting hepatocytes in vivo will be destroyed by the autoimmune processes that kill pancreatic beta cells has not been fully addressed. It is possible that the insulin secreting liver cells will be destroyed by the immune system because hepatocytes express major histocompatibility complex (MHC) class I molecules and exhibit constitutive Fas expression; moreover the liver has antigen presenting activity. Read More

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http://dx.doi.org/10.1186/1740-2557-1-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544947PMC
November 2004
7 Reads

Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease.

J Autoimmune Dis 2004 Oct 15;1(1). Epub 2004 Oct 15.

Research Laboratory of Internal Medicine, Department of Medicine, Larissa Medical School, University of Thessaly, Larissa 41222, Greece.

Autoimmune hepatitis (AIH) is a chronic necroinflammatory disease of the liver characterized by hypergammaglobulinemia, characteristic autoantibodies, association with HLA DR3 or DR4 and a favorable response to immunosuppressive treatment. The etiology is unknown. The detection of non-organ and liver-related autoantibodies remains the hallmark for the diagnosis of the disease in the absence of viral, metabolic, genetic, and toxic etiology of chronic hepatitis or hepatic injury. Read More

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http://jautoimdis.biomedcentral.com/articles/10.1186/1740-25
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http://dx.doi.org/10.1186/1740-2557-1-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544946PMC
October 2004
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Why do we need a new journal in autoimmunity?

J Autoimmune Dis 2004 Oct 13;1(1). Epub 2004 Oct 13.

The Rayne Institute, St Thomas' Hospital, London, UK.

A new online Journal of Autoimmune Diseases is created as an independent open access journal. In addition to the obvious advantages of the open access, the Journal will practice a double-blind reviewing of the manuscripts, which means that both the reviewers and the authors remain anonymous to each other. We believe that such a policy will reduce the influence of personal and other non-scientific factors on the reviewer's decision making. Read More

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http://dx.doi.org/10.1186/1740-2557-1-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544945PMC
October 2004
4 Reads
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