1,887 results match your criteria Journal of Atherosclerosis and Thrombosis [Journal]


Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases.

Authors:
Masato Furuhashi

J Atheroscler Thromb 2019 Feb 7. Epub 2019 Feb 7.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine.

Fatty acid-binding proteins (FABPs), a family of lipid chaperones, contribute to systemic metabolic regulation via several lipid signaling pathways. Fatty acid-binding protein 4 (FABP4), known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays important roles in the development of insulin resistance and atherosclerosis in relation to metabolically driven low-grade and chronic inflammation, referred to as 'metaflammation'. FABP4 is secreted from adipocytes in a non-classical pathway associated with lipolysis and acts as an adipokine for the development of insulin resistance and atherosclerosis. Read More

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http://dx.doi.org/10.5551/jat.48710DOI Listing
February 2019
2 Reads

Lipoprotein Subfractions and Glucose Homeostasis in Prediabetes and Diabetes in Taiwan.

J Atheroscler Thromb 2019 Feb 7. Epub 2019 Feb 7.

Department of Insured Medical Care Management, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU).

Aims: Prediabetes and diabetes are associated with increased insulin resistance and decreased insulin production, dyslipidemia, and increased cardiovascular disease (CVD) risk. Our goals were to assess lipoprotein subfractions using novel assays in such subjects.

Methods: Fasting normal, prediabetic, and diabetic Taiwanese men and women (n=2,049) had their serum glucose, glycosylated hemoglobin, insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), HDL3-C, apolipoprotein E-HDL-C, direct low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C), LDL-TG, and remnant lipoprotein cholesterol (RLP-C) levels measured using novel assays. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_483
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http://dx.doi.org/10.5551/jat.48330DOI Listing
February 2019
3 Reads

Association between Prescription and Control Status of Dyslipidemia and Hypertension among Japanese Patients with Diabetes.

J Atheroscler Thromb 2019 Feb 6. Epub 2019 Feb 6.

Department of Internal Medicine, Teikyo University.

Aims: The proper management of atherosclerotic risk factors (ARFs) and attainment of target levels (TLs) for ARFs are crucial in preventing atherosclerotic cardiovascular disease (ASCVD). In this study, utilizing data from the "Specific Health Check and Guidance in Japan," which was conducted from 2008 to 2011, we examined TL attainment status of low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) and prescription status of dyslipidemia and hypertension in patients with diabetes undergoing medical treatment, and analyzed the factors that affected prescription status.

Methods: Subjects receiving medical treatment for diabetes were selected from the database. Read More

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http://dx.doi.org/10.5551/jat.47597DOI Listing
February 2019
1 Read

Patients with Acute Ischemic Cerebrovascular Disease with Coronary Artery Stenosis Have More Diffused Cervicocephalic Atherosclerosis.

J Atheroscler Thromb 2019 Feb 6. Epub 2019 Feb 6.

Department of Radiology, Xuanwu Hospital, Capital Medical University.

Aim: Coronary artery stenosis (CAS) ≥ 50% frequently coexists in patients with acute ischemic cerebrovascular disease (AICVD), which portends unfavorable outcomes. We sought to examine whether patients with AICVD with CAS had more severe and more diffused cervicocephalic atherosclerosis (CA).

Methods: Patients with AICVD were consecutively enrolled and underwent simultaneous computed tomography angiography (CTA) of the coronary and cervicocephalic arteries. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_474
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http://dx.doi.org/10.5551/jat.47464DOI Listing
February 2019
2 Reads

Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study.

J Atheroscler Thromb 2019 Jan 31. Epub 2019 Jan 31.

Department of Public Health, Hokkaido University Faculty of Medicine.

Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial.

Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Read More

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http://dx.doi.org/10.5551/jat.46383DOI Listing
January 2019
1 Read

Association of Plasma Pentraxin-3 Level with Lipid Levels and Cardiovascular Risk Factors in People with No History of Lipid-Lowering Medication: the Dong-gu Study.

J Atheroscler Thromb 2019 Jan 23. Epub 2019 Jan 23.

Department of Preventive Medicine, Chonnam National University Medical School.

Aim: To elucidate the role of pentraxin-3 (PTX3) in atherosclerosis, we evaluated lipid and cardiovascular risk profiles according to the plasma PTX3 levels in subjects from the general population.

Methods: A sub-cohort of 2,000 subjects was randomly sampled from a Korean community-based cohort study. After excluding those with a medication history for dyslipidemia, 1,747 subjects (902 men and 845 women) were included in the final analyses. Read More

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http://dx.doi.org/10.5551/jat.47167DOI Listing
January 2019
1 Read

Diagnosis and Management of Statin Intolerance.

J Atheroscler Thromb 2019 Jan 19. Epub 2019 Jan 19.

Cardiovacular Prevention Department. Sanatorio Finochietto.

Statins are the main treatment for hypercholesterolemia and the cornerstone of atherosclerotic cardiovascular disease prevention. Many patients taking statins report muscle-related symptoms, one of the most important causes of statin treatment discontinuation, which is associated with an increased risk of cardiovascular events. Therefore, it is important to identify patients who are truly statin intolerant to avoid unnecessary discontinuation of this beneficial treatment. Read More

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http://dx.doi.org/10.5551/jat.RV17030DOI Listing
January 2019
1 Read

Cerebral Arterial Stiffness as A New Marker of Early Stage Atherosclerosis of The Cerebral Large Artery in Acute Stroke.

J Atheroscler Thromb 2019 Jan 19. Epub 2019 Jan 19.

Institute of Neuroscience and Department of Neurology, the Second Affiliated Hospital of Guangzhou Medical University.

Aim: Carotid-cerebral pulse wave velocity (ccPWV) reflects the segment (C-M segment) stiffness between the common carotid artery and ipsilateral middle cerebral artery. C-M segment atherosclerosis (CMSA) is regarded the most frequent cause of anterior circulation ischemic stroke. We aimed to evaluate the association of ccPWV with early stage CMSA in this study. Read More

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http://dx.doi.org/10.5551/jat.46573DOI Listing
January 2019
2 Reads

Serum Triglyceride Lipase Concentrations are Independent Risk Factors for Coronary Artery Disease and In-Stent Restenosis.

J Atheroscler Thromb 2019 Jan 17. Epub 2019 Jan 17.

Department of Cardiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University.

Aim: Endothelial lipase (EL), hepatic lipase (HL), and lipoprotein lipase (LPL) are all triglyceride lipases and are associated with coronary artery disease (CAD). However, whether they can be simultaneous independent risk factors for CAD is unknown. In the present study, we investigated whether the three lipases can be independent risk factors simultaneously for CAD and whether combining these lipases could provide greater predictive power than high-density lipoprotein cholesterol (HDL-c) for the development of CAD. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_468
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http://dx.doi.org/10.5551/jat.46821DOI Listing
January 2019
5 Reads

Investigation of the Underlying Genes and Mechanism of Macrophage-Enriched Ruptured Atherosclerotic Plaques Using Bioinformatics Method.

J Atheroscler Thromb 2019 Jan 15. Epub 2019 Jan 15.

Department of Neurosurgery, Beijing Luhe Hospital, Capital Medical University.

Aim: The study aimed to identify the underlying differentially expressed genes (DEGs) and mechanism of macrophage-enriched rupture atherosclerotic plaque using bioinformatics methods.

Methods: GSE41571, which includes six stable samples and five ruptured atherosclerotic samples, was downloaded from the GEO database. After preprocessing, DEGs between ruptured and stable atherosclerotic samples were identified using LIMMA. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_459
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http://dx.doi.org/10.5551/jat.45963DOI Listing
January 2019
4 Reads

Shape and Location of Carotid Atherosclerotic Plaque and Intraplaque Hemorrhage: A High-resolution Magnetic Resonance Imaging Study.

J Atheroscler Thromb 2019 Jan 9. Epub 2019 Jan 9.

Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine.

Aim: The present study aimed to investigate the association between shape and location of atherosclerotic plaques and intraplaque hemorrhage (IPH) in carotid arteries using magnetic resonance (MR) imaging.

Methods: Overall, 114 symptomatic patients (mean age: 64.9±10. Read More

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http://dx.doi.org/10.5551/jat.47449DOI Listing
January 2019

Positive Association Between Small Dense Low-Density Lipoprotein Cholesterol Concentration and Biomarkers of Inflammation, Thrombosis, and Prediabetes in Non-Diabetic Adults.

J Atheroscler Thromb 2018 Dec 26. Epub 2018 Dec 26.

Departments of Internal Medicine and Environmental and Occupational Medicine, National Taiwan University.

Aims: Recent studies suggest elevated levels of small dense low-density lipoprotein cholesterol (sdLDL-C) can predict the risk of incident coronary heart disease (CHD), even in individuals considered to be at low risk for cardiovascular disease(CVD) based on their LDL-C levels. This study aims to prospectively investigate the association between sdLDL-C concentration and traditional and nontraditional CHD risk markers to explore the underlying roles of sdLDL-C in atherogenic processes.

Methods: Between 2009 and 2011, 594 healthy volunteers aged 35-65 years were recruited as control subjects in a study of work-related risk factors and acute CHD. Read More

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http://dx.doi.org/10.5551/jat.43968DOI Listing
December 2018
1 Read

Effect of Resistant Starch on the Gut Microbiota and Its Metabolites in Patients with Coronary Artery Disease.

J Atheroscler Thromb 2018 Dec 27. Epub 2018 Dec 27.

Graduate School of Science, Technology and Innovation, Kobe University.

Aim: Bacteroides vulgatus and B. dorei have a protective effect against atherosclerosis, suggesting that expansion of these species in the gut microbiota could help patients with coronary artery disease (CAD). This study aimed to investigate the effect of resistant starch (RS) on the gut microbiota and its metabolites in fecal sample cultures from patients with CAD and individuals without CAD, using a single-batch fermentation system. Read More

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http://dx.doi.org/10.5551/jat.47415DOI Listing
December 2018

Impact of Nutritional and Inflammation Status on Long-Term Bleeding in Patients Undergoing Percutaneous Coronary Intervention with an Oral Anticoagulant.

J Atheroscler Thromb 2018 Dec 22. Epub 2018 Dec 22.

Department of Cardiology, Nagoya University Graduate School of Medicine.

Aim: Patients undergoing percutaneous coronary intervention (PCI) who require both oral anticoagulant (OAC) and antiplatelet therapy (APT) are exposed to a serious risk of bleeding. The aim of this study was to clarify the relationship among nutritional and inflammation status and long-term bleeding in patients requiring both OACs and APT after PCI.

Methods: We performed PCI in 3,718 consecutive patients between April 2011 and March 2017, 302 of whom were treated with both OACs and APT. Read More

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http://dx.doi.org/10.5551/jat.47654DOI Listing
December 2018

Bezafibrate Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Hypertriglyceridemic Patients with Type 2 Diabetes Mellitus.

J Atheroscler Thromb 2018 Dec 22. Epub 2018 Dec 22.

Center of Diabetes, Endocrinology and Metabolism, Toho University, Sakura Medical Center.

Aim: Cardio-ankle vascular index (CAVI) reflects arterial stiffness and has been established as a useful surrogate marker of atherosclerosis. Contrary to the abundant data indicating slower progression of atherosclerosis with statins, studies on fibrates remain scarce. The aim of this study was thus to clarify the effect of bezafibrate on CAVI as well as on oxidative stress. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_457
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http://dx.doi.org/10.5551/jat.45799DOI Listing
December 2018
6 Reads

Cholesterol and Inflammation in Stroke Recurrence.

Authors:
Yoshiki Yagita

J Atheroscler Thromb 2018 Dec 20. Epub 2018 Dec 20.

Department of Stroke Medicine, Kawasaki Medical School.

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http://dx.doi.org/10.5551/jat.ED107DOI Listing
December 2018

Plaque Volume and Morphology are Associated with Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography.

J Atheroscler Thromb 2018 Dec 20. Epub 2018 Dec 20.

Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital.

Aim: Coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFR) accurately diagnoses ischemic lesions of intermediate stenosis severity. However, significant determinants of FFR have not been fully evaluated.

Methods: This was a sub-analysis of the Treatment of Alogliptin on Coronary Atherosclerosis Evaluated by Computed Tomography-Based Fractional Flow Reserve trial. Read More

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http://dx.doi.org/10.5551/jat.47621DOI Listing
December 2018
1 Read

Liver Transplantation for Homozygous Familial Hypercholesterolemia.

J Atheroscler Thromb 2019 Feb 15;26(2):121-127. Epub 2018 Dec 15.

Diabetes and Lifestyle-related Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association.

Pharmacological treatments to decrease low-density lipoprotein (LDL) cholesterol (LDL-C) have limited effects on patients with homozygous familial hypercholesterolemia (HoFH). Since LDL receptors are located mainly in the liver, liver transplantation is considered to be the only way to correct the hepatic cholesterol metabolism abnormalities in HoFH. Liver transplantations, including those combined with heart transplantation, for HoFH have been increasing since 1984, making this a globally established therapeutic option for HoFH. Read More

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http://dx.doi.org/10.5551/jat.RV17029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365147PMC
February 2019
1 Read

Microparticles from Endothelial Cells and Immune Cells in Patients with Takayasu Arteritis.

J Atheroscler Thromb 2018 Dec 15. Epub 2018 Dec 15.

Institute of Microbiology, Chinese Academy of Sciences.

Aim: This study was designed to analyze microparticles (MPs) from endothelial cells (EMPs) and immune cells from healthy individuals and paitents with Takayasu arteritis (TA), and any possible relationships between MPs and TA acitivity.

Methods: MPs derived from the plasma of 51 subjects were analyzed, including 32 patients with TA and 19 healthy individuals. Flow cytometry was performed with Annexin (Anx)-V and antibodies against surface markers of endothelial cells (CD144), T cells (CD3), B cells (CD19), and monocytes (CD14). Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_453
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http://dx.doi.org/10.5551/jat.45351DOI Listing
December 2018
7 Reads

Assessment of HDL Cholesterol Removal Capacity: Toward Clinical Application.

Authors:
Ryuji Toh

J Atheroscler Thromb 2019 Feb 12;26(2):111-120. Epub 2018 Dec 12.

Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine.

While there is a controversy regarding the causal relationship between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD), recent studies have demonstrated that the cholesterol efflux capacity (CEC) of HDL is associated with the incidence of CVD. However, there are several limitations to current assays of CEC. First, CEC measurements are not instantly applicable in clinical settings, because CEC assay methods require radiolabeled cholesterol and cultured cells, and these procedures are time consuming. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_RV1
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http://dx.doi.org/10.5551/jat.RV17028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365149PMC
February 2019
5 Reads

Associations Between Plasma Betatrophin Levels and Coronary and Peripheral Artery Disease.

J Atheroscler Thromb 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiology, National Hospital Organization Tokyo Medical Center.

Aim: Betatrophin, a recently identified circulating adipokine, affects lipid and glucose metabolism. However, association between plasma betatrophin levels and atherosclerotic diseases, such as coronary artery disease (CAD) and peripheral artery disease (PAD), has not been elucidated.

Methods: We investigated plasma betatrophin levels in 457 patients undergoing elective coronary angiography who also had ankle-brachial index (ABI) test for PAD screening. Read More

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http://dx.doi.org/10.5551/jat.46508DOI Listing
December 2018
1 Read

Investigation into Lipid Management in Acute Coronary Syndrome Patients from the EXPLORE-J Study.

J Atheroscler Thromb 2018 Dec 4. Epub 2018 Dec 4.

Department of Molecular Innovation in Lipidology, National Cerebral & Cardiovascular Center Research Institute.

Aims: The EXPLORE-J study aimed to assess lipid management in patients hospitalized for acute coronary syndrome (ACS) and their cardiovascular risk despite undergoing standard therapy. Here, we focused on background characteristics of patients in the EXPLORE-J study to elucidate the current lipid-lowering therapy and its issues in Japan.

Methods: In this multicenter, prospective, observational study (UMIN000018946), consecutive Japanese ACS patients who required hospitalization were registered between April 2015 and August 2016. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_455
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http://dx.doi.org/10.5551/jat.45583DOI Listing
December 2018
10 Reads

Coefficients in the CAVI Equation and the Comparison Between CAVI With and Without the Coefficients Using Clinical Data.

J Atheroscler Thromb 2018 Dec 4. Epub 2018 Dec 4.

Mihama Hospital.

Aim: The Cardio-Ankle Vascular Index (CAVI) is a stiffness index of the arterial tree from the origin of the aorta to the ankle, independent of blood pressure at the time of measurement. The CAVI equation includes the coefficients "a" and "b" to adjust it to the value of Hasegawa's pulse wave velocity, which is compensated for at 80 mmHg of diastolic pressure. To verify this adjustment with the coefficients, the clinical significance of CAVI and CAVI without the coefficients (haβ) were compared in both an epidemiological study and an acute clinical study. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_448
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http://dx.doi.org/10.5551/jat.44834DOI Listing
December 2018
8 Reads

The Association of Cardio-Ankle Vascular Index and Ankle-Brachial Index with Macroangiopathy in Patients with Type 2 Diabetes Mellitus.

J Atheroscler Thromb 2018 Nov 28. Epub 2018 Nov 28.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

Aims: This study elucidates the association of macroangiopathy development in type 2 diabetes patients with various arteriosclerosis risk factors (ARFs) and results of cardio-ankle vascular index (CAVI) and ankle-brachial pressure index (ABI).

Methods: The correlation between current and past macroangiopathy development, with ARFs or CAVI/ABI data, was retrospectively analyzed using multivariate logistic regression in 816 patients with type 2 diabetes at a single center. C-statistics combining some independent variables selected using the stepwise method were evaluated. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_456
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http://dx.doi.org/10.5551/jat.45674DOI Listing
November 2018
11 Reads

Statin Intolerance and Suboptimal Statin Therapy.

J Atheroscler Thromb 2018 Nov 22. Epub 2018 Nov 22.

Division of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medical Sciences.

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http://dx.doi.org/10.5551/jat.ED106DOI Listing
November 2018

Low Cholesterol Levels Increase Symptomatic Intracranial Hemorrhage Rates After Intravenous Thrombolysis: A Multicenter Cohort Validation Study.

J Atheroscler Thromb 2018 Nov 21. Epub 2018 Nov 21.

School of Public Health, College of Public Health, Taipei Medical University.

Aim: Although a lower level of non-high-density lipoprotein cholesterol (HDL-C) was reported to be inversely associated with spontaneous intracranial hemorrhage (ICH), no enough evidence has verified whether lipid profiles modify hemorrhagic transformation and functional outcomes in patients with acute ischemic treated with thrombolysis.

Methods: This multicenter cohort study included 2373 patients with acute ischemic stroke treated with intravenous thrombolysis between December 2004 and December 2016. Of these, 1845 patients were categorized into either the hyperlipidemia or non-hyperlipidemia group. Read More

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http://dx.doi.org/10.5551/jat.46151DOI Listing
November 2018
11 Reads

Synergistic Effects of 1 h Post-Load Plasma Glucose and Smoking on Arterial Stiffness in Apparently Healthy Men: A Cross-sectional Study.

J Atheroscler Thromb 2018 Nov 17. Epub 2018 Nov 17.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine.

Aim: One-hour post-load plasma glucose (1h-PG) during an oral glucose tolerance test and smoking are associated with arterial stiffness. However, it remains unknown whether there are synergistic effects of these two factors on arterial stiffness. This study aimed to investigate the interaction between 1h-PG and smoking in relation to brachial-ankle pulse wave velocity (baPWV) in young men with normal glucose tolerance (NGT). Read More

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http://dx.doi.org/10.5551/jat.46193DOI Listing
November 2018

Prestroke Aspirin Use is Associated with Clinical Outcomes in Ischemic Stroke Patients with Atherothrombosis, Small Artery Disease, and Cardioembolic Stroke.

J Atheroscler Thromb 2018 Nov 14. Epub 2018 Nov 14.

Department of Neurology, People's Hospital of Deyang City.

Aim: To evaluate the effect of prestroke aspirin (PA) use on initial stroke severity, early neurologic deterioration (END), stroke recurrence, hemorrhagic transformation (HT), and functional outcome in patients with ischemic stroke (IS).

Methods: This was a prospective, observational, multicenter cohort study. The acute IS patients with atherothrombosis (AT), small artery disease (SAD), or cardioembolic (CE) stroke within 24 hours of symptom onset were identified. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_461
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http://dx.doi.org/10.5551/jat.46136DOI Listing
November 2018
7 Reads

The Release of Monocyte-Derived Tissue Factor-Positive Microparticles Contributes to a Hypercoagulable State in Idiopathic Membranous Nephropathy.

J Atheroscler Thromb 2018 Nov 15. Epub 2018 Nov 15.

Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University.

Aim: Idiopathic membranous nephropathy (IMN) is an immune-mediated inflammatory disease characterized by a high risk of thromboembolic complications. Microparticles (MPs), a type of extracellular vesicles, have procoagulant properties, especially when they display tissue factor (TF). This study aimed to investigate whether circulating TF-positive MPs contributed to the hypercoagulable state in patients with IMN. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_462
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http://dx.doi.org/10.5551/jat.46284DOI Listing
November 2018
13 Reads

Pathogenesis of Atypical Hemolytic Uremic Syndrome.

J Atheroscler Thromb 2019 Feb 2;26(2):99-110. Epub 2018 Nov 2.

Division of Nephrology and Endocrinology, the University of Tokyo Hospital.

Atypical hemolytic uremic syndrome (aHUS) is a type of thrombotic microangiopathy (TMA) defined by thrombocytopenia, microangiopathic hemolytic anemia, and renal failure. aHUS is caused by uncontrolled complement activation in the alternative pathway (AP). A variety of genetic defects in complement-related factors or acquired autoantibodies to the complement regulators have been found in 50 to 60% of all cases. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_RV1
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http://dx.doi.org/10.5551/jat.RV17026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365154PMC
February 2019
10 Reads

Effects of Aerobic Exercise Alone on Lipids in Healthy East Asians: A Systematic Review and Meta-Analysis.

J Atheroscler Thromb 2018 Oct 31. Epub 2018 Oct 31.

Faculty of Health and Sport Sciences, University of Tsukuba.

Aim: The purpose of the current work was to review the effects of regular aerobic exercise on serum lipid and lipoprotein levels in East Asians using meta-analysis.

Methods: The randomized controlled trials analyzed involved healthy adults who were East Asians with a mean age ≥40 years, an exercise group that only performed regular aerobic exercise, and a control group that did not carry out exercise-related intervention; the trials indicated mean high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), or triglyceride (TG). The mean difference (MD) was defined as the difference (mean value at post-intervention in the exercise group-mean value at baseline in the exercise group)-(mean value at post-intervention in the control group-mean value at baseline in the control group) in HDL-C, LDL-C, TC, and TG and was calculated for each trial. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_458
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http://dx.doi.org/10.5551/jat.45864DOI Listing
October 2018
1 Read

Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men.

J Atheroscler Thromb 2018 Nov 1. Epub 2018 Nov 1.

Center for Epidemiologic Research in Asia, Shiga University of Medical Science.

Aims: Calcification in the coronary and aortic arteries has been linked to cardiovascular morbidity and mortality. The pathophysiological influence of aortic artery calcification (AAC) differs from that of coronary artery calcification (CAC). We aimed to compare the relationships between CAC and AAC and cardiovascular disease (CVD) risk factors. Read More

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http://dx.doi.org/10.5551/jat.44784DOI Listing
November 2018
1 Read

Physical Fitness and Development of High Non-High-Density Lipoprotein Cholesterol.

Authors:
Shinji Koba

J Atheroscler Thromb 2018 Dec 29;25(12):1185-1187. Epub 2018 Oct 29.

Division of Cardiology, Department of Medicine, Showa University School of Medicine.

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http://dx.doi.org/10.5551/jat.ED105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249365PMC
December 2018

Real-World Data to Identify Hypercholesterolemia Patients on Suboptimal Statin Therapy.

J Atheroscler Thromb 2018 Oct 26. Epub 2018 Oct 26.

Teikyo Academic Research Center.

Aim: Statins are generally well-tolerated but some patients develop adverse events and down-titrate or discontinue statins. It is important to understand the frequency of dyslipidemia patients with the inability to continue statins. The aim of the present study was to identify the frequency of high-risk dyslipidemia patients who are unable to take or not taking statins for any reason using Japanese hospital claims database. Read More

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http://dx.doi.org/10.5551/jat.46201DOI Listing
October 2018

Usefulness of Carotid Arterial Strain Values for Evaluating the Arteriosclerosis.

J Atheroscler Thromb 2018 Oct 20. Epub 2018 Oct 20.

Vascular Center, Sanno Hospital and Sanno Medical Center.

Aim: We investigated the clinical usefulness of carotid arterial strain and the strain rate for evaluating the progression of arteriosclerosis measured using a two-dimensional speckle-tracking method in carotid ultrasonography.

Methods: We enrolled 259 participants (age: 64±12 years; men: 149; women: 110) in this retrospective analysis. The circumferential strain and the strain rate were measured in bilateral common carotid arteries, and the lowest values were used for the analyses. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_455
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http://dx.doi.org/10.5551/jat.45591DOI Listing
October 2018
12 Reads

Cumulative Effects of LDL Cholesterol and CRP Levels on Recurrent Stroke and TIA.

J Atheroscler Thromb 2018 Oct 15. Epub 2018 Oct 15.

Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences.

Aims: To investigate the relative contribution of on-treatment low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) to the risk of recurrent stroke and transient ischemic attack (TIA) in patients with history of ischemic stroke.

Methods: A total of 1095 patients with non-cardioembolic ischemic stroke were randomized into two groups: control and patients receiving 10 mg of pravastatin per day. After excluding 18 patients who did not have baseline CRP data, the effects of LDL cholesterol and CRP on recurrent stroke and TIA were prospectively assessed in 1077 patients. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_459
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http://dx.doi.org/10.5551/jat.45989DOI Listing
October 2018
10 Reads

Prognostic Value of International Normalized Ratio in Ischemic Stroke Patients without Atrial Fibrillation or Anticoagulation Therapy.

J Atheroscler Thromb 2018 Oct 12. Epub 2018 Oct 12.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University.

Aim: The impact of international normalized ratio (INR) on prognosis after acute ischemic stroke without anticoagulation therapy is unclear. Herein, the association between baseline INR and stroke outcomes in patients without anticoagulation therapy was investigated.

Methods: A total of 14,782 ischemic stroke patients from the China National Stroke Registry Ⅱ were included in this analysis. Read More

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http://dx.doi.org/10.5551/jat.43752DOI Listing
October 2018
1 Read

Postprandial Hyperlipemia is an Indication for Additional Risk in Sitosterolemia.

J Atheroscler Thromb 2018 Dec 11;25(12):1183-1184. Epub 2018 Oct 11.

Division of Anti-aging and Vascular Medicine, Department of Internal Medicine, National Defense Medical College.

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http://dx.doi.org/10.5551/jat.ED104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249361PMC
December 2018

Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells.

J Atheroscler Thromb 2018 Oct 4. Epub 2018 Oct 4.

Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University.

Aim: Acyl-CoA cholesterol acyltransferase 1 (ACAT1) esterifies free cholesterol to cholesteryl esters (CE), which are subsequently hydrolyzed by neutral cholesterol ester hydrolase 1 (NCEH1). The elimination of ACAT1 in vitro reduces the amounts of CE accumulated in Nceh1-deficient macrophages. The present study aimed at examining whether the loss of ACAT1 attenuates atherosclerosis which is aggravated by the loss of NCEH1 in vivo. Read More

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http://dx.doi.org/10.5551/jat.44040DOI Listing
October 2018
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Safety and Efficacy of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia (HoFH): Results from the AEGR-733-301 Long-Term Extension Study.

J Atheroscler Thromb 2018 Sep 26. Epub 2018 Sep 26.

Aegerion Pharmaceuticals, Inc.

Aim: Lomitapide is an approved lipid-lowering agent indicated as adjunct to low-fat diet and standard lipid-lowering therapies (LLTs) including lipoprotein apheresis for the treatment of homozygous familial hypercholesterolemia (HoFH). Clinical data from Phase 3 studies have demonstrated the prolonged lipid-lowering capacity of lomitapide in patients with HoFH. We assessed the long-term lipid-lowering capacity of daily oral lomitapide in a cohort of Japanese patients with HoFH enrolled in a Phase 3 extension study. Read More

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http://dx.doi.org/10.5551/jat.45708DOI Listing
September 2018
13 Reads

Inflammatory Mediators Across the Spectrum of Ankle-Brachial Index.

J Atheroscler Thromb 2018 Sep 25. Epub 2018 Sep 25.

Department of Biochemistry, Namik Kemal University Faculty of Medicine.

Aim: Peripheral artery disease (PAD) is a manifestation of atherosclerosis with poor prognosis. It is generally complicated by vascular calcification, which is located either in the intima as patchy infiltrates; or circumferentially in the media, also known as medial arterial calcification (MAC). Obstructive PAD is reflected by low anklebrachial index (ABI ≤ 0. Read More

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http://dx.doi.org/10.5551/jat.44891DOI Listing
September 2018

Low Baseline High-Sensitive C-Reactive Protein is Associated with Coronary Atherosclerosis Regression: Insights from the MILLION Study.

J Atheroscler Thromb 2018 Sep 21. Epub 2018 Sep 21.

Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine.

Aim: The prospective, randomized, multicenter Myocardial Ischemia Treated with Percutaneous Coronary Intervention and Plaque Regression by Lipid Lowering & Blood Pressure Controlling assessed by Intravascular Ultrasonography (MILLION) study demonstrated that combined treatment with atorvastatin and amlodipine enhanced coronary artery plaque regression. Although the baseline high-sensitive C-reactive protein (hs-CRP) reportedly plays an important role in atherogenesis, few data exist regarding the relationship between hs-CRP and plaque regression in patients receiving a combined atorvastatin and amlodipine therapy.

Methods: A total of 68 patients (male, 55; mean age, 64. Read More

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http://dx.doi.org/10.5551/jat.44255DOI Listing
September 2018
1 Read

In Memoriam: Yuichiro Goto, MD (October 6, 1992 - May 28, 2003).

J Atheroscler Thromb 2018 Sep 20;11(2):98-100. Epub 2018 Sep 20.

Medizinischen Kernklinik Universitätsklinikum.

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http://dx.doi.org/10.5551/jat.11.98DOI Listing
September 2018

Management goals by patient category.

Authors:
Yasushi Saito

J Atheroscler Thromb 2018 Sep 20;11(2):101-103. Epub 2018 Sep 20.

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http://dx.doi.org/10.5551/jat.11.101DOI Listing
September 2018

Mechanism and Management of Cancer Chemotherapy-Induced Atherosclerosis.

J Atheroscler Thromb 2018 Oct 14;25(10):994-1002. Epub 2018 Sep 14.

Osaka Prefectural Hospital Organization, Osaka International Cancer Institute, Department of Medical Checkup, Onco-Cardiology Unit.

The advent of new chemotherapeutic and immunotherapeutic treatments has markedly improved outcomes in patients with cancer. However, increasing numbers of elderly patients with cancer and prolonged periods of treatment have made the management of cardiovascular complications and treatment-induced cardiotoxicity an important concern, and onco-cardiology has received increasing attention. The number of patients with cardiotoxicity, particularly atherosclerotic lesions, and the usage of angiogenesis inhibitors have increased, making the involvement of onco-cardiologists essential for effective disease management. Read More

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http://dx.doi.org/10.5551/jat.RV17027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193189PMC
October 2018
9 Reads

Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals.

J Atheroscler Thromb 2019 Jan 14;26(1):50-63. Epub 2018 Sep 14.

Section of Cardiovascular Medicine, Yale School of Medicine.

Aims: There is limited knowledge about the association of lipoprotein particles and markers of coronary atherosclerosis such as coronary artery calcification (CAC) in relatively young high-risk persons. This study examines the association of lipoprotein subfractions and CAC in high cardiometabolic risk individuals.

Methods: The study presents analysis from baseline data of a randomized trial targeted at high-risk workers. Read More

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http://dx.doi.org/10.5551/jat.40741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308270PMC
January 2019
3 Reads

Problems that Physicians should Notice for Better Treatment of Hypercholesterolemia in Japan.

Authors:
Yoshio Fujioka

J Atheroscler Thromb 2019 Feb 13;26(2):134-135. Epub 2018 Sep 13.

Division of Clinical Nutrition, Faculty of Nutrition, Kobe Gakuin University.

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http://dx.doi.org/10.5551/jat.ED103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365158PMC
February 2019

Relation of Elevated Serum Uric Acid Level to Endothelial Dysfunction in Patients with Acute Coronary Syndrome.

J Atheroscler Thromb 2018 Sep 13. Epub 2018 Sep 13.

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine.

Aim: Serum uric acid (SUA) level is known to have a prognostic value in patients with acute coronary syndrome (ACS). Endothelial function plays an important role in the development of cardiovascular disease. Although relation between SUA level and endothelial function has been previously studied in various populations, it is partially understood in patients with ACS. Read More

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http://dx.doi.org/10.5551/jat.45179DOI Listing
September 2018
1 Read