1,911 results match your criteria Journal of Atherosclerosis and Thrombosis [Journal]


Eczema and Risk of Cardiovascular Disease: Heightened Awareness Needed.

Authors:
Akira Fujiyoshi

J Atheroscler Thromb 2019 Apr 16. Epub 2019 Apr 16.

Department of Hygiene, Wakayama Medical University.

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http://dx.doi.org/10.5551/jat.ED109DOI Listing

Persistent Dysfunction of Coronary Endothelial Vasomotor Responses is Related to Atheroma Plaque Progression in the Infarct-Related Coronary Artery of AMI Survivors.

J Atheroscler Thromb 2019 Apr 16. Epub 2019 Apr 16.

Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine.

Aim: Although coronary endothelial vasomotor dysfunction predicts future coronary events, there are few human studies showing the relationship between endothelial vasomotor dysfunction and atheroma plaque progression in the same coronary artery. This study examined whether endothelial vasomotor dysfunction is related to atheroma plaque progression in the infarct-related coronary artery of ST-segment elevation myocardial infarction (STEMI) survivors using serial assessment of coronary plaque size with intravascular ultrasound (IVUS) and coronary vasomotor responses to acetylcholine (ACh).

Methods: This study included 50 patients with a first acute STEMI due to occlusion of the left anterior descending coronary artery (LAD) and successful reperfusion therapy with percutaneous coronary intervention (PCI). Read More

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http://dx.doi.org/10.5551/jat.48249DOI Listing

Five-Year Patency and its Predictors after Endovascular Therapy for Aortoiliac Occlusive Disease.

J Atheroscler Thromb 2019 Apr 16. Epub 2019 Apr 16.

Cardiovascular Center, Kansai Rosai Hospital.

Aim: Although current guidelines recommend surgical revascularization as the first-line therapy for chronic total occlusion of the abdominal aorta (Leriche syndrome), endovascular therapy (EVT) has been increasingly utilized because of the development of new technologies and techniques. EVT has demonstrated durable midterm outcomes for aortoiliac occlusive disease (AIOD). Nonetheless, little is known regarding their long-term outcomes and predictors of restenosis. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_456
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http://dx.doi.org/10.5551/jat.45617DOI Listing
April 2019
4 Reads

The Elevated Soluble ST2 Predicts No-Reflow Phenomenon in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

J Atheroscler Thromb 2019 Apr 18. Epub 2019 Apr 18.

Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital.

Aim: The primary percutaneous procedure resulted in a significant improvement in the prognosis of myocardial infarction. However, no-reflow phenomenon restrains this benefit of the process. There are studies suggesting that soluble suppression of tumorigenicity (sST2) can be valuable in the diagnosis and progression of heart failure and myocardial infarction. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_484
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http://dx.doi.org/10.5551/jat.48413DOI Listing
April 2019
4 Reads

Metformin Attenuates Early-Stage Atherosclerosis in Mildly Hyperglycemic Oikawa-Nagao Mice.

J Atheroscler Thromb 2019 Apr 11. Epub 2019 Apr 11.

Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School.

Aim: Although metformin treatment has been reported to reduce the risk of cardiovascular events in patients with type 2 diabetes, the underlying mechanisms have not been elucidated fully. Here we assessed atherosclerotic lesion formation in newly established 2 mouse lines with different blood glucose levels (Oikawa-Nagao Diabetes-Prone [ON-DP] and -Resistant [ON-DR]) to evaluate the effect of metformin on early-stage atherosclerosis.

Methods: Mildly hyperglycemic ON-DP and normoglycemic ON-DR female mice fed an atherogenic diet for 20 weeks (8-28 weeks of age). Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_482
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http://dx.doi.org/10.5551/jat.48223DOI Listing
April 2019
1 Read

A Novel Cell-Free, Non-Fluorescent Method to Measure Lox-1- Binding Activity Corresponding to The Functional Activity of HDL.

J Atheroscler Thromb 2019 Apr 3. Epub 2019 Apr 3.

Department of Molecular Pathophysiology, School of Medicine, Shinshu University.

Aims: A functional abnormality in high-density lipoprotein (HDL) particles rather than a quantitative abnormality in HDL cholesterol levels has been suggested to promote atherosclerosis. The modification of HDL may underlie functional changes to HDL such as gaining the ability to bind and activate the lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1). We aimed to develop a novel method for measuring modified HDL on the basis of its binding to LOX-1. Read More

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http://dx.doi.org/10.5551/jat.47183DOI Listing

Clinical Applications of a Novel Selective PPARα Modulator, Pemafibrate, in Dyslipidemia and Metabolic Diseases.

J Atheroscler Thromb 2019 Mar 30. Epub 2019 Mar 30.

Sumitomo Hospital.

Fasting and postprandial hypertriglyceridemia is a risk factor for atherosclerotic cardiovascular diseases (ASCVD). Fibrates have been used to treat dyslipidemia, particularly hypertriglyceridemia, and low HDL-cholesterol (HDL-C). However, conventional fibrates have low selectivity for peroxisome proliferator-activated receptor (PPAR)α. Read More

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http://dx.doi.org/10.5551/jat.48918DOI Listing

Arterial Stiffness and Endothelial Function in Young Obese Patients - Vascular Resistance Matters.

J Atheroscler Thromb 2019 Mar 30. Epub 2019 Mar 30.

Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Department of Physiology.

Aim: Motivated by the paradoxical and differing results of the early atherosclerosis related indices - Cardio-Ankle Vascular Index (CAVI) reflecting arterial stiffness and Reactive Hyperemia Index (RHI) evaluating endothelium dependent flow-induced vasodilation - in obesity, we aimed to assess CAVI and RHI in obese adolescents and young adults in the context of differences in systemic vascular resistance (SVR).

Methods: We examined 29 obese (14f, 15.4 [12. Read More

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http://dx.doi.org/10.5551/jat.47530DOI Listing
March 2019
1 Read

Aortic Plaque Distribution, and Association between Aortic Plaque and Atherosclerotic Risk Factors: An Aortic Angioscopy Study.

J Atheroscler Thromb 2019 Mar 27. Epub 2019 Mar 27.

Cardiovascular Center, Yokosuka Kyosai Hospital.

Aim: Knowledge of subclinical plaque morphology and plaque distribution in the aorta in vivo remains unclear. This study aimed to increase the body of knowledge in this area.

Methods: We enrolled 37 consecutive patients with stable angina pectoris patients who underwent non-obstructive angioscopy for both the coronary artery and aorta immediately after percutaneous coronary intervention. Read More

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http://dx.doi.org/10.5551/jat.48181DOI Listing
March 2019
1 Read

Asymptomatic Basilar Artery Plaque Distribution and Vascular Geometry.

J Atheroscler Thromb 2019 Mar 27. Epub 2019 Mar 27.

Department of Radiology, Hanyang University Hospital.

Aim: Development of atherosclerotic plaques is affected by vascular geometry and hemodynamics. Hemodynamics in the basilar artery (BA) is unique as the flow converges from vertebral arteries (VAs). Here, we investigated the characteristics of BA plaque based on VA and BA geometry. Read More

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http://dx.doi.org/10.5551/jat.47365DOI Listing

Comparison of Two Homogeneous LDL-Cholesterol Assays Using Fresh Hypertriglyceridemic Serum and Quantitative Ultracentrifugation Fractions.

J Atheroscler Thromb 2019 Mar 19. Epub 2019 Mar 19.

Department of Cardiology, Fukuoka University School of Medicine.

Aim: The purpose of this study was to compare two homogeneous assays of low-density lipoprotein-cholesterol (LDL-C) with a modified beta quantification reference measurement for LDL-C (BQ-LDL), fractions of chylomicron (CM), very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) by quantitative ultracentrifugation in patients with hypertriglyceridemia.

Methods: Two homogeneous LDL-C assays (LDL-C(K), Kyowa Medex and LDL-C(S), Sekisui Medical) were used to measure 198 samples of fresh anonymized leftover sera with hypertriglyceridemia (≥ 150 mg/dL). Of these, 32 samples with discrepant LDL-C levels or hypertriglyceridemia (≥ 400 mg/dL) were used for further analysis. Read More

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http://dx.doi.org/10.5551/jat.47191DOI Listing
March 2019
2 Reads

High Prevalence of Cerebral Small Vessel Disease on 7T Magnetic Resonance Imaging in Familial Hypercholesterolemia.

J Atheroscler Thromb 2019 Mar 15. Epub 2019 Mar 15.

Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Iwate Medical University.

Aim: It remains unclear whether elevated low-density lipoprotein cholesterol (LDL-C) is a risk factor for cerebral vascular disease. Familial hypercholesterolemia (FH) is the most appropriate model for understanding the effects of excess LDL-C because affected individuals have inherently high levels of circulating LDL-C. To clarify the effects of hypercholesterolemia on cerebral small vessel disease (SVD), we investigated cerebrovascular damage in detail due to elevated LDL-C using high resolution brain magnetic resonance imaging (MRI) in patients with FH. Read More

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http://dx.doi.org/10.5551/jat.48553DOI Listing
March 2019
1 Read

Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction.

J Atheroscler Thromb 2019 Mar 14. Epub 2019 Mar 14.

Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.

Aim: A direct oral anti-coagulant, FXa inhibitor, has been applied to the clinical treatment of myocardial infarction (MI). Experimental studies in mice indicated that FXa inhibitors reduced atherosclerosis and prevented cardiac dysfunction after coronary ligation. These studies suggested that protease-activated receptor (PAR) 2, a major receptor of activated FX, may play an important role in atherosclerosis and cardiac remodeling. Read More

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http://dx.doi.org/10.5551/jat.48405DOI Listing
March 2019
1 Read

Serum Anti-Apo B Antibody Level as Residual CVD Marker in DM Patients under Statin Treatment.

J Atheroscler Thromb 2019 Mar 14. Epub 2019 Mar 14.

Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine.

Aim: In the pathogenesis of atherosclerosis, autoantibodies have two-facedness of progression and protection. Previous reports have indicated that low autoantibody levels against apolipoprotein B-100 (apo B-100) could increase the risk of atherosclerotic cardiovascular diseases (CVD) in healthy subjects. In this study, we investigated the relationship between circulating anti-apo B-100 autoantibodies and the clinical parameters in Japanese diabetic patients with or without CVD. Read More

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http://dx.doi.org/10.5551/jat.46797DOI Listing

Acquired von Willebrand Syndrome Associated with Cardiovascular Diseases.

J Atheroscler Thromb 2019 Apr 12;26(4):303-314. Epub 2019 Mar 12.

Department of Blood Transfusion Medicine, Nara Medical University.

The blood glycoprotein von Willebrand factor (VWF) plays an important role in hemostasis and thrombosis.VWF is produced and secreted as large multimers by endothelial cells and megakaryocytes. It is then cleaved in a sheer-stress dependent manner by a specific protease, ADAMTS13, into multimers consisting of 2-80 subunits. Read More

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http://dx.doi.org/10.5551/jat.RV17031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456452PMC
April 2019
1 Read

Time-Dependent Change in Omentin-1 Level Correlated with Early Improvement of Myocardial Function in Patients with First Anterior ST-Segment Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention.

J Atheroscler Thromb 2019 Mar 9. Epub 2019 Mar 9.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University.

Aim: Omentin-1, as a novel adipocytokine, ameliorates obesity-associated disorders and suppresses the development of atherosclerotic lesions. The present research investigated the correlation between serum omentin-1 and post-infarction myocardial function.

Methods: A total of 52 patients with first anterior ST-segment elevation myocardial infarction (STEMI) were recruited into this study. Read More

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http://dx.doi.org/10.5551/jat.47043DOI Listing

Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project.

J Atheroscler Thromb 2019 Mar 6. Epub 2019 Mar 6.

Unit for the Detection and Treatment of Atherothrombotic Diseases (UDETMA V&R). University Hospital Arnau de Vilanova.

Aim: Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in subjects with low to moderate vascular risk.

Methods: A cross-sectional study in which 2,568 non-diabetic subjects of both sexes without cardiovascular disease were included. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_474
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http://dx.doi.org/10.5551/jat.47498DOI Listing
March 2019
4 Reads

One-Year Clinical Outcomes following Implantation of Innova Self-Expanding Nitinol Stents in Patients with Peripheral Artery Diseases Presenting Femoropopliteal Artery Lesions.

J Atheroscler Thromb 2019 Mar 5. Epub 2019 Mar 5.

Department of Cardiology, Kokura Memorial Hospital.

Aim: Although the Innova self-expanding nitinol stent (Boston Scientific, Marlborough, MA) exhibits acceptable performance in long-term safety and efficacy when used for the treatment of femoropopliteal (FP) lesions, clinical outcomes following its implantation have not been systematically studied in real-world settings. We investigated the one-year clinical outcomes after implantation of Innova self-expanding nitinol stents for the treatment of FP lesions in real-world settings.

Methods: In this multicenter study, 481 lesions in 453 consecutive patients with peripheral artery disease (PAD) (74±9 years; male, 70%; diabetes mellitus, 61%; dialysis, 27%; critical limb ischemia, 37%) who underwent endovascular therapy with the implantation of Innova self-expanding nitinol stents for FP lesions were analyzed from February 2016 to April 2017. Read More

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http://dx.doi.org/10.5551/jat.47399DOI Listing
March 2019
4 Reads

Prognostic Value of Plasma Big Endothelin-1 Level among Patients with Three-Vessel Disease: A Cohort Study.

J Atheroscler Thromb 2019 Mar 1. Epub 2019 Mar 1.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.

Aim: To evaluate the prognostic value of plasma big endothelin-1 level in the context of three-vessel disease (TVD) with heavy atherosclerotic burden.

Methods: A total of 6,150 patients with TVD and available big endothelin-1 data were included in the study. Participants were divided into two groups according to the optimal cutoff value of big endothelin-1 for mortality prediction. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_473
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http://dx.doi.org/10.5551/jat.47324DOI Listing
March 2019
5 Reads

Interaction between an ATP-Binding Cassette A1 (ABCA1) Variant and Egg Consumption for the Risk of Ischemic Stroke and Carotid Atherosclerosis: a Family-Based Study in the Chinese Population.

J Atheroscler Thromb 2019 Mar 1. Epub 2019 Mar 1.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University.

Aim: ATP-binding cassette A1 (ABCA1) plays an important role in reducing the risk of stroke. Egg is the major source of dietary cholesterol and is known to be associated with the risk of stroke and atherosclerosis. We aimed to assess the effects of interaction between an ABCA1 variant (rs2066715) and egg consumption on the risk of ischemic stroke (IS), carotid plaque, and carotid-intima media thickness (CIMT) in the Chinese population. Read More

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http://dx.doi.org/10.5551/jat.46615DOI Listing
March 2019
2.733 Impact Factor

Which is the Best Predictor for the Development of Atherosclerosis Among Circulating Lipoprotein Lipase, Hepatic Lipase, and Endothelial Lipase?

Authors:
Junji Kobayashi

J Atheroscler Thromb 2019 Feb 27. Epub 2019 Feb 27.

Kanazawa Medical University General Internal Medicine.

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http://dx.doi.org/10.5551/jat.ED108DOI Listing
February 2019

Sleep Disordered Breathing and Cardiovascular Diseases.

J Atheroscler Thromb 2019 Apr 28;26(4):315-327. Epub 2019 Feb 28.

Department of Cardiovascular Medicine, Fukushima Medical University.

Sleep disordered breathing (SDB), which causes sleep deprivation, intermittent hypoxia, and negative intrathoracic pressure swings, can be accompanied by other harmful pathophysiologies relating to cardiovascular diseases (CVD), including sudden death, atrial fibrillation, stroke, and coronary artery disease leading to heart failure. Continuous positive airway pressure (CPAP) therapy for SDB has been reported to provide favorable effects such as lowered systemic blood pressure and improved endothelial function. However, in recent randomized controlled trials, CPAP has failed to demonstrate its beneficial prognostic impact on the primary or secondary setting of CVD. Read More

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http://dx.doi.org/10.5551/jat.RV17032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456453PMC
April 2019
3 Reads

Visceral Adiposity Index as an Independent Marker of Subclinical Atherosclerosis in Individuals Prone to Diabetes Mellitus.

J Atheroscler Thromb 2019 Feb 19. Epub 2019 Feb 19.

Department of Internal Medicine IV, Division of Endocrinology and Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University Hospital of Tübingen.

Aim: The visceral adiposity index (VAI) has been proposed as an estimate of visceral adipose tissue (VAT) mass and as an indicator of VAT dysfunction. Both parameters are associated with cardiometabolic risk, including insulin resistance. In this study, we investigated whether VAI is associated with subclinical atherosclerosis in subjects who were free of cardiovascular disease but were at risk of developing diabetes mellitus. Read More

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http://dx.doi.org/10.5551/jat.47274DOI Listing
February 2019

High Serum Secreted Frizzled-Related Protein 5 Levels Associated with Early Improvement of Cardiac Function Following ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention.

J Atheroscler Thromb 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiology, 12th ward, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease.

Aim: Several members of secreted frizzled-related protein (SFRP) are involved in the process of myocardial ischemia-reperfusion injury. However, little is known about the role of SFRP5 in patients with acute ST-segment elevation myocardial infarction (STEMI).

Methods: In this cross-sectional study, 85 patients with first-time anterior STEMI who underwent timely primary percutaneous coronary intervention (PCI) and 35 patients without coronary artery disease (CAD) were enrolled. Read More

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http://dx.doi.org/10.5551/jat.47019DOI Listing
February 2019
3 Reads

Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases.

Authors:
Masato Furuhashi

J Atheroscler Thromb 2019 Mar 7;26(3):216-232. Epub 2019 Feb 7.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine.

Fatty acid-binding proteins (FABPs), a family of lipid chaperones, contribute to systemic metabolic regulation via several lipid signaling pathways. Fatty acid-binding protein 4 (FABP4), known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays important roles in the development of insulin resistance and atherosclerosis in relation to metabolically driven low-grade and chronic inflammation, referred to as 'metaflammation'. FABP4 is secreted from adipocytes in a non-classical pathway associated with lipolysis and acts as an adipokine for the development of insulin resistance and atherosclerosis. Read More

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http://dx.doi.org/10.5551/jat.48710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402888PMC
March 2019
3 Reads

Lipoprotein Subfractions and Glucose Homeostasis in Prediabetes and Diabetes in Taiwan.

J Atheroscler Thromb 2019 Feb 7. Epub 2019 Feb 7.

Department of Insured Medical Care Management, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU).

Aims: Prediabetes and diabetes are associated with increased insulin resistance and decreased insulin production, dyslipidemia, and increased cardiovascular disease (CVD) risk. Our goals were to assess lipoprotein subfractions using novel assays in such subjects.

Methods: Fasting normal, prediabetic, and diabetic Taiwanese men and women (n=2,049) had their serum glucose, glycosylated hemoglobin, insulin, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), HDL3-C, apolipoprotein E-HDL-C, direct low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C), LDL-TG, and remnant lipoprotein cholesterol (RLP-C) levels measured using novel assays. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_483
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http://dx.doi.org/10.5551/jat.48330DOI Listing
February 2019
8 Reads

Association between Prescription and Control Status of Dyslipidemia and Hypertension among Japanese Patients with Diabetes.

J Atheroscler Thromb 2019 Feb 6. Epub 2019 Feb 6.

Department of Internal Medicine, Teikyo University.

Aims: The proper management of atherosclerotic risk factors (ARFs) and attainment of target levels (TLs) for ARFs are crucial in preventing atherosclerotic cardiovascular disease (ASCVD). In this study, utilizing data from the "Specific Health Check and Guidance in Japan," which was conducted from 2008 to 2011, we examined TL attainment status of low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) and prescription status of dyslipidemia and hypertension in patients with diabetes undergoing medical treatment, and analyzed the factors that affected prescription status.

Methods: Subjects receiving medical treatment for diabetes were selected from the database. Read More

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http://dx.doi.org/10.5551/jat.47597DOI Listing
February 2019
2 Reads

Patients with Acute Ischemic Cerebrovascular Disease with Coronary Artery Stenosis Have More Diffused Cervicocephalic Atherosclerosis.

J Atheroscler Thromb 2019 Feb 6. Epub 2019 Feb 6.

Department of Radiology, Xuanwu Hospital, Capital Medical University.

Aim: Coronary artery stenosis (CAS) ≥ 50% frequently coexists in patients with acute ischemic cerebrovascular disease (AICVD), which portends unfavorable outcomes. We sought to examine whether patients with AICVD with CAS had more severe and more diffused cervicocephalic atherosclerosis (CA).

Methods: Patients with AICVD were consecutively enrolled and underwent simultaneous computed tomography angiography (CTA) of the coronary and cervicocephalic arteries. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_474
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http://dx.doi.org/10.5551/jat.47464DOI Listing
February 2019
11 Reads
2.733 Impact Factor

Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study.

J Atheroscler Thromb 2019 Jan 31. Epub 2019 Jan 31.

Department of Public Health, Hokkaido University Faculty of Medicine.

Aim: Previous studies suggested a positive association between eczema and cardiovascular disease (CVD), probably through enhanced systemic inflammation. However, several studies reported null findings about eczema and CVD, so the evidence is still controversial.

Methods: We asked 85,099 participants (35,489 men and 49,610 women), aged 40 to 79 years, without a history of CVD or cancer at baseline between 1988 and 1990, to complete a lifestyle questionnaire, including information eczema frequency (seldom, sometimes or often). Read More

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http://dx.doi.org/10.5551/jat.46383DOI Listing
January 2019
1 Read

Association of Plasma Pentraxin-3 Level with Lipid Levels and Cardiovascular Risk Factors in People with No History of Lipid-Lowering Medication: the Dong-gu Study.

J Atheroscler Thromb 2019 Jan 23. Epub 2019 Jan 23.

Department of Preventive Medicine, Chonnam National University Medical School.

Aim: To elucidate the role of pentraxin-3 (PTX3) in atherosclerosis, we evaluated lipid and cardiovascular risk profiles according to the plasma PTX3 levels in subjects from the general population.

Methods: A sub-cohort of 2,000 subjects was randomly sampled from a Korean community-based cohort study. After excluding those with a medication history for dyslipidemia, 1,747 subjects (902 men and 845 women) were included in the final analyses. Read More

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http://dx.doi.org/10.5551/jat.47167DOI Listing
January 2019
1 Read

Diagnosis and Management of Statin Intolerance.

J Atheroscler Thromb 2019 Mar 19;26(3):207-215. Epub 2019 Jan 19.

Cardiovacular Prevention Department. Sanatorio Finochietto.

Statins are the main treatment for hypercholesterolemia and the cornerstone of atherosclerotic cardiovascular disease prevention. Many patients taking statins report muscle-related symptoms, one of the most important causes of statin treatment discontinuation, which is associated with an increased risk of cardiovascular events. Therefore, it is important to identify patients who are truly statin intolerant to avoid unnecessary discontinuation of this beneficial treatment. Read More

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http://dx.doi.org/10.5551/jat.RV17030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402887PMC
March 2019
1 Read

Cerebral Arterial Stiffness as A New Marker of Early Stage Atherosclerosis of The Cerebral Large Artery in Acute Stroke.

J Atheroscler Thromb 2019 Jan 19. Epub 2019 Jan 19.

Institute of Neuroscience and Department of Neurology, the Second Affiliated Hospital of Guangzhou Medical University.

Aim: Carotid-cerebral pulse wave velocity (ccPWV) reflects the segment (C-M segment) stiffness between the common carotid artery and ipsilateral middle cerebral artery. C-M segment atherosclerosis (CMSA) is regarded the most frequent cause of anterior circulation ischemic stroke. We aimed to evaluate the association of ccPWV with early stage CMSA in this study. Read More

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http://dx.doi.org/10.5551/jat.46573DOI Listing
January 2019
3 Reads

Serum Triglyceride Lipase Concentrations are Independent Risk Factors for Coronary Artery Disease and In-Stent Restenosis.

J Atheroscler Thromb 2019 Jan 17. Epub 2019 Jan 17.

Department of Cardiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University.

Aim: Endothelial lipase (EL), hepatic lipase (HL), and lipoprotein lipase (LPL) are all triglyceride lipases and are associated with coronary artery disease (CAD). However, whether they can be simultaneous independent risk factors for CAD is unknown. In the present study, we investigated whether the three lipases can be independent risk factors simultaneously for CAD and whether combining these lipases could provide greater predictive power than high-density lipoprotein cholesterol (HDL-c) for the development of CAD. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_468
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http://dx.doi.org/10.5551/jat.46821DOI Listing
January 2019
13 Reads

Investigation of the Underlying Genes and Mechanism of Macrophage-Enriched Ruptured Atherosclerotic Plaques Using Bioinformatics Method.

J Atheroscler Thromb 2019 Jan 15. Epub 2019 Jan 15.

Department of Neurosurgery, Beijing Luhe Hospital, Capital Medical University.

Aim: The study aimed to identify the underlying differentially expressed genes (DEGs) and mechanism of macrophage-enriched rupture atherosclerotic plaque using bioinformatics methods.

Methods: GSE41571, which includes six stable samples and five ruptured atherosclerotic samples, was downloaded from the GEO database. After preprocessing, DEGs between ruptured and stable atherosclerotic samples were identified using LIMMA. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_459
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http://dx.doi.org/10.5551/jat.45963DOI Listing
January 2019
5 Reads

Shape and Location of Carotid Atherosclerotic Plaque and Intraplaque Hemorrhage: A High-resolution Magnetic Resonance Imaging Study.

J Atheroscler Thromb 2019 Jan 9. Epub 2019 Jan 9.

Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine.

Aim: The present study aimed to investigate the association between shape and location of atherosclerotic plaques and intraplaque hemorrhage (IPH) in carotid arteries using magnetic resonance (MR) imaging.

Methods: Overall, 114 symptomatic patients (mean age: 64.9±10. Read More

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http://dx.doi.org/10.5551/jat.47449DOI Listing
January 2019
1 Read

Positive Association Between Small Dense Low-Density Lipoprotein Cholesterol Concentration and Biomarkers of Inflammation, Thrombosis, and Prediabetes in Non-Diabetic Adults.

J Atheroscler Thromb 2018 Dec 26. Epub 2018 Dec 26.

Departments of Internal Medicine and Environmental and Occupational Medicine, National Taiwan University.

Aims: Recent studies suggest elevated levels of small dense low-density lipoprotein cholesterol (sdLDL-C) can predict the risk of incident coronary heart disease (CHD), even in individuals considered to be at low risk for cardiovascular disease(CVD) based on their LDL-C levels. This study aims to prospectively investigate the association between sdLDL-C concentration and traditional and nontraditional CHD risk markers to explore the underlying roles of sdLDL-C in atherogenic processes.

Methods: Between 2009 and 2011, 594 healthy volunteers aged 35-65 years were recruited as control subjects in a study of work-related risk factors and acute CHD. Read More

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http://dx.doi.org/10.5551/jat.43968DOI Listing
December 2018
2 Reads

Effect of Resistant Starch on the Gut Microbiota and Its Metabolites in Patients with Coronary Artery Disease.

J Atheroscler Thromb 2018 Dec 27. Epub 2018 Dec 27.

Graduate School of Science, Technology and Innovation, Kobe University.

Aim: Bacteroides vulgatus and B. dorei have a protective effect against atherosclerosis, suggesting that expansion of these species in the gut microbiota could help patients with coronary artery disease (CAD). This study aimed to investigate the effect of resistant starch (RS) on the gut microbiota and its metabolites in fecal sample cultures from patients with CAD and individuals without CAD, using a single-batch fermentation system. Read More

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http://dx.doi.org/10.5551/jat.47415DOI Listing
December 2018
1 Read

Impact of Nutritional and Inflammation Status on Long-Term Bleeding in Patients Undergoing Percutaneous Coronary Intervention with an Oral Anticoagulant.

J Atheroscler Thromb 2018 Dec 22. Epub 2018 Dec 22.

Department of Cardiology, Nagoya University Graduate School of Medicine.

Aim: Patients undergoing percutaneous coronary intervention (PCI) who require both oral anticoagulant (OAC) and antiplatelet therapy (APT) are exposed to a serious risk of bleeding. The aim of this study was to clarify the relationship among nutritional and inflammation status and long-term bleeding in patients requiring both OACs and APT after PCI.

Methods: We performed PCI in 3,718 consecutive patients between April 2011 and March 2017, 302 of whom were treated with both OACs and APT. Read More

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http://dx.doi.org/10.5551/jat.47654DOI Listing
December 2018
2 Reads

Bezafibrate Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Hypertriglyceridemic Patients with Type 2 Diabetes Mellitus.

J Atheroscler Thromb 2018 Dec 22. Epub 2018 Dec 22.

Center of Diabetes, Endocrinology and Metabolism, Toho University, Sakura Medical Center.

Aim: Cardio-ankle vascular index (CAVI) reflects arterial stiffness and has been established as a useful surrogate marker of atherosclerosis. Contrary to the abundant data indicating slower progression of atherosclerosis with statins, studies on fibrates remain scarce. The aim of this study was thus to clarify the effect of bezafibrate on CAVI as well as on oxidative stress. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_457
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http://dx.doi.org/10.5551/jat.45799DOI Listing
December 2018
10 Reads

Cholesterol and Inflammation in Stroke Recurrence.

Authors:
Yoshiki Yagita

J Atheroscler Thromb 2018 Dec 20. Epub 2018 Dec 20.

Department of Stroke Medicine, Kawasaki Medical School.

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http://dx.doi.org/10.5551/jat.ED107DOI Listing
December 2018
1 Read

Plaque Volume and Morphology are Associated with Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography.

J Atheroscler Thromb 2018 Dec 20. Epub 2018 Dec 20.

Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital.

Aim: Coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFR) accurately diagnoses ischemic lesions of intermediate stenosis severity. However, significant determinants of FFR have not been fully evaluated.

Methods: This was a sub-analysis of the Treatment of Alogliptin on Coronary Atherosclerosis Evaluated by Computed Tomography-Based Fractional Flow Reserve trial. Read More

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http://dx.doi.org/10.5551/jat.47621DOI Listing
December 2018
4 Reads

Liver Transplantation for Homozygous Familial Hypercholesterolemia.

J Atheroscler Thromb 2019 Feb 15;26(2):121-127. Epub 2018 Dec 15.

Diabetes and Lifestyle-related Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association.

Pharmacological treatments to decrease low-density lipoprotein (LDL) cholesterol (LDL-C) have limited effects on patients with homozygous familial hypercholesterolemia (HoFH). Since LDL receptors are located mainly in the liver, liver transplantation is considered to be the only way to correct the hepatic cholesterol metabolism abnormalities in HoFH. Liver transplantations, including those combined with heart transplantation, for HoFH have been increasing since 1984, making this a globally established therapeutic option for HoFH. Read More

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http://dx.doi.org/10.5551/jat.RV17029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365147PMC
February 2019
2 Reads

Microparticles from Endothelial Cells and Immune Cells in Patients with Takayasu Arteritis.

J Atheroscler Thromb 2018 Dec 15. Epub 2018 Dec 15.

Institute of Microbiology, Chinese Academy of Sciences.

Aim: This study was designed to analyze microparticles (MPs) from endothelial cells (EMPs) and immune cells from healthy individuals and paitents with Takayasu arteritis (TA), and any possible relationships between MPs and TA acitivity.

Methods: MPs derived from the plasma of 51 subjects were analyzed, including 32 patients with TA and 19 healthy individuals. Flow cytometry was performed with Annexin (Anx)-V and antibodies against surface markers of endothelial cells (CD144), T cells (CD3), B cells (CD19), and monocytes (CD14). Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_453
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http://dx.doi.org/10.5551/jat.45351DOI Listing
December 2018
13 Reads

Assessment of HDL Cholesterol Removal Capacity: Toward Clinical Application.

Authors:
Ryuji Toh

J Atheroscler Thromb 2019 Feb 12;26(2):111-120. Epub 2018 Dec 12.

Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine.

While there is a controversy regarding the causal relationship between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD), recent studies have demonstrated that the cholesterol efflux capacity (CEC) of HDL is associated with the incidence of CVD. However, there are several limitations to current assays of CEC. First, CEC measurements are not instantly applicable in clinical settings, because CEC assay methods require radiolabeled cholesterol and cultured cells, and these procedures are time consuming. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_RV1
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http://dx.doi.org/10.5551/jat.RV17028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365149PMC
February 2019
12 Reads

Associations Between Plasma Betatrophin Levels and Coronary and Peripheral Artery Disease.

J Atheroscler Thromb 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiology, National Hospital Organization Tokyo Medical Center.

Aim: Betatrophin, a recently identified circulating adipokine, affects lipid and glucose metabolism. However, association between plasma betatrophin levels and atherosclerotic diseases, such as coronary artery disease (CAD) and peripheral artery disease (PAD), has not been elucidated.

Methods: We investigated plasma betatrophin levels in 457 patients undergoing elective coronary angiography who also had ankle-brachial index (ABI) test for PAD screening. Read More

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http://dx.doi.org/10.5551/jat.46508DOI Listing
December 2018
4 Reads

Investigation into Lipid Management in Acute Coronary Syndrome Patients from the EXPLORE-J Study.

J Atheroscler Thromb 2018 Dec 4. Epub 2018 Dec 4.

Department of Molecular Innovation in Lipidology, National Cerebral & Cardiovascular Center Research Institute.

Aims: The EXPLORE-J study aimed to assess lipid management in patients hospitalized for acute coronary syndrome (ACS) and their cardiovascular risk despite undergoing standard therapy. Here, we focused on background characteristics of patients in the EXPLORE-J study to elucidate the current lipid-lowering therapy and its issues in Japan.

Methods: In this multicenter, prospective, observational study (UMIN000018946), consecutive Japanese ACS patients who required hospitalization were registered between April 2015 and August 2016. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_455
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http://dx.doi.org/10.5551/jat.45583DOI Listing
December 2018
13 Reads

Coefficients in the CAVI Equation and the Comparison Between CAVI With and Without the Coefficients Using Clinical Data.

J Atheroscler Thromb 2018 Dec 4. Epub 2018 Dec 4.

Mihama Hospital.

Aim: The Cardio-Ankle Vascular Index (CAVI) is a stiffness index of the arterial tree from the origin of the aorta to the ankle, independent of blood pressure at the time of measurement. The CAVI equation includes the coefficients "a" and "b" to adjust it to the value of Hasegawa's pulse wave velocity, which is compensated for at 80 mmHg of diastolic pressure. To verify this adjustment with the coefficients, the clinical significance of CAVI and CAVI without the coefficients (haβ) were compared in both an epidemiological study and an acute clinical study. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_448
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http://dx.doi.org/10.5551/jat.44834DOI Listing
December 2018
12 Reads

The Association of Cardio-Ankle Vascular Index and Ankle-Brachial Index with Macroangiopathy in Patients with Type 2 Diabetes Mellitus.

J Atheroscler Thromb 2018 Nov 28. Epub 2018 Nov 28.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

Aims: This study elucidates the association of macroangiopathy development in type 2 diabetes patients with various arteriosclerosis risk factors (ARFs) and results of cardio-ankle vascular index (CAVI) and ankle-brachial pressure index (ABI).

Methods: The correlation between current and past macroangiopathy development, with ARFs or CAVI/ABI data, was retrospectively analyzed using multivariate logistic regression in 816 patients with type 2 diabetes at a single center. C-statistics combining some independent variables selected using the stepwise method were evaluated. Read More

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https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_456
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http://dx.doi.org/10.5551/jat.45674DOI Listing
November 2018
20 Reads

Statin Intolerance and Suboptimal Statin Therapy.

J Atheroscler Thromb 2018 Nov 22. Epub 2018 Nov 22.

Division of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medical Sciences.

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http://dx.doi.org/10.5551/jat.ED106DOI Listing
November 2018
1 Read