3,712 results match your criteria Journal of Asthma & Allergy Educators [Journal]


Severe asthma and bronchiectasis.

J Asthma 2019 Feb 20:1-5. Epub 2019 Feb 20.

a Department of Pneumology , Hospital Universitario Central de Asturias , Oviedo , Spain.

Objective: The aim of our study was to determine the tomographic findings and prevalence of bronchiectasis in our population of patients with severe asthma, and to identify factors associated with the presence of bronchiectasis in these patients.

Materials And Methods: We retrospectively collected data from the medical histories of patients referred to the asthma unit of our hospital, with a diagnosis of severe asthma between 2015 and 2017. Patients with ABPA, cystic fibrosis, immunodeficiency or systemic disease were excluded. Read More

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http://dx.doi.org/10.1080/02770903.2019.1579832DOI Listing
February 2019

Relationship between asthma status and antibody response pattern to 23-valent pneumococcal vaccination.

J Asthma 2019 Feb 20:1-10. Epub 2019 Feb 20.

h Department of Pediatric and Adolescent Medicine/Internal Medicine , Mayo Clinic , Rochester , MN , USA.

Objective: Asthma poses an increased risk for serious pneumococcal disease, but little is known about the influence of asthma status on the 23-valent serotype-specific pneumococcal antibody response. We examined differences in antibody titers between pre- and post-vaccination with 23-valent pneumococcal polysaccharide vaccine (PPSV-23) in relation to asthma status.

Methods: Asthma status was retrospectively ascertained by the Predetermined Asthma Criteria in an existing vaccine cohort through comprehensive medical record review. Read More

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http://dx.doi.org/10.1080/02770903.2019.1575394DOI Listing
February 2019

Exploring factors associated with health disparities in asthma and poorly controlled asthma among school-aged children in the U.S.

J Asthma 2019 Feb 7:1-14. Epub 2019 Feb 7.

f University of North Texas , Fort Worth , Texas , USA.

Objective: Certain populations suffer disproportionately from asthma and asthma morbidity. The objective was to provide a national descriptive profile of asthma control and treatment patterns among school-aged children (SAC: aged 6-17) in the U.S. Read More

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http://dx.doi.org/10.1080/02770903.2019.1571080DOI Listing
February 2019

The role of serum nuclear factor erythroid 2-related factor 2 in childhood bronchial asthma.

J Asthma 2019 Feb 7:1-6. Epub 2019 Feb 7.

c Neonatology, Kasr Alainy Faculty of Medicine , Cairo University , Cairo , Egypt.

Background: Asthma is one of the most common chronic airway disease of childhood. Poor asthma control has been associated with antioxidant deficiencies.

Objective: To assess the association of bronchial asthma in Egyptian children with serum nuclear factor erythroid 2-related factor2 (NRF2) and its relation to disease severity. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2019.1
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http://dx.doi.org/10.1080/02770903.2019.1571081DOI Listing
February 2019
4 Reads

Trends in the use of cigarettes, cigars, and marijuana among students with and without asthma, 2003-2017.

J Asthma 2019 Feb 7:1-7. Epub 2019 Feb 7.

c Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion , Centers for Disease Control and Prevention , Atlanta , GA , USA.

Aim: Asthma has symptoms that can be exacerbated by using combustible products such as tobacco and marijuana. This study assessed the prevalence and trends in current use of cigarettes, cigars, and marijuana among U.S. Read More

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http://dx.doi.org/10.1080/02770903.2019.1573254DOI Listing
February 2019

Role of technology in improving knowledge and confidence in asthma management in school staff.

J Asthma 2019 Feb 5:1-6. Epub 2019 Feb 5.

a Respiratory Department , Sydney Children's Hospital , Sydney , Australia.

Objective: To investigate the effectiveness of technology enabled learning in improving asthma first aid knowledge and self-confidence in providing asthma first aid to children in staff within a school setting.

Study Design: A prospective randomized parallel study using a pre and post test design was conducted across Metropolitan schools of New South Wales (NSW), Australia. School staff in selected schools were randomly assigned to receive first aid asthma management training via a self-directed multimedia eBook learning resource or standard face-to-face training. Read More

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http://dx.doi.org/10.1080/02770903.2019.1571087DOI Listing
February 2019
1 Read

Prevalence of symptoms of asthma and allergic rhinitis in children in Southern Brazil: a ten-year monitoring study.

J Asthma 2019 Feb 5:1-8. Epub 2019 Feb 5.

b Universidade Federal de Ciências da Saúde de Porto Alegre, Programa de Pós-Graduação em Patologia , Porto Alegre , RS , Brazil.

Objective: This study analyzes and describes trends in prevalence of asthma and rhinitis in children 6-7 years old living in Santo Ângelo, Brazil, by comparing data from 2007, 2012, and 2017.

Methods: The ISAAC (International Study of Asthma and Allergies in Childhood) standardized written questionnaire was used in a three cross-sectional survey. The questionnaire was applied between March and May of 2007, 2012 and 2017. Read More

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http://dx.doi.org/10.1080/02770903.2019.1573253DOI Listing
February 2019
2 Reads

Filarial tropical pulmonary eosinophilia.

J Asthma 2019 Feb 5. Epub 2019 Feb 5.

b Dr DY Patil University , Pune , India.

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http://dx.doi.org/10.1080/02770903.2018.1561892DOI Listing
February 2019
2 Reads

Development and validation of the family management scale for children with asthma (FMSCA).

J Asthma 2019 Feb 4:1-11. Epub 2019 Feb 4.

a School of Nursing , Beijing University of Chinese Medicine , Beijing , China.

Objective: This study aims to develop and validate the Family Management Scale for Children with Asthma (FMSCA) in China context.

Methods: Based on the Family Management Style Framework (FMSF) model, an original 89 items were generated from literature review and interviews with 15 caregivers of children with asthma. The preliminary scale was refined to 82 items through two rounds of experts' evaluation and a pilot study, then administered to 329 caregivers of children with asthma for testing between April and July 2013. Read More

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http://dx.doi.org/10.1080/02770903.2019.1571085DOI Listing
February 2019
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Respiratory tract infection-induced asthma exacerbations in adults with asthma: assessing predictors and outcomes.

J Asthma 2019 Feb 4:1-10. Epub 2019 Feb 4.

b Department of Clinical Pharmacy & Therapeutics, Faculty of Pharmacy , Applied Science Private University , Amman , Jordan.

Objective: To evaluate clinical and economic burden associated with respiratory tract infection (RTI)-induced asthma exacerbations and to identify risk factors associated with these exacerbations. Factors associated with these exacerbations are understudied and little information is available about consequent expenditures.

Methods: In this retrospective case-control study, medical records and pharmacy data in King Abdullah University Hospital in Northern Jordan were reviewed for adults with asthma aged 40 years and older, over the period 2013-2016. Read More

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http://dx.doi.org/10.1080/02770903.2019.1568454DOI Listing
February 2019
2 Reads

Diagnostic value of fractional exhaled nitric oxide in cough-variant asthma: an updated meta-analysis.

J Asthma 2019 Feb 1:1-8. Epub 2019 Feb 1.

a Department of Respiratory , Peking University International Hospital , Beijing , China.

Objective: We aimed to evaluate the diagnostic value of fractional exhaled nitric oxide (FeNO) in cough-variant asthma (CVA) detection.

Methods: Relevant studies on the FeNO test in patients with CVA were retrieved from electronic databases including PubMed, Medline, Springer, Elsevier Science Direct, the Cochrane Library, and Google Scholar, up to August 2018. Meta-analysis for sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) of the FeNO test were conducted after extracting related data from the included studies. Read More

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http://dx.doi.org/10.1080/02770903.2019.1568452DOI Listing
February 2019

Association between asthma, obesity, and health behaviors in African American youth.

J Asthma 2019 Jan 31:1-11. Epub 2019 Jan 31.

a Childhood Disparities Research Laboratory , University of Michigan , Ann Arbor , Michigan , USA.

Background: There is a clear relationship between obesity and asthma, with obesity recognized as a risk factor for asthma. There is mounting evidence, however, that asthma may predict obesity risk via behavioral pathways.

Objectives: The purpose of this study was to assess the cross-sectional relationships between asthma, body mass index (BMI) percentile, and behavioral factors including caloric intake, dietary inflammatory index, moderate-vigorous physical activity (MVPA), and sedentary time (SED) among African American adolescents. Read More

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http://dx.doi.org/10.1080/02770903.2019.1571083DOI Listing
January 2019
2 Reads

A cross sectional survey on health-related quality of life among parents of children with allergic symptoms using the EQ-5D-5L.

J Asthma 2019 Jan 31:1-7. Epub 2019 Jan 31.

c Department of Nursing , Dankook University College of Nursing , Cheonan , Republic of Korea.

Object: This study aims to evaluate the HRQOL of parents of children with allergic diseases using the EQ-5D-5L.

Methods: The subjects of the study were parents of children enrolled in primary schools and daycare centers. The EQ-5D-5L was self-administered in the sample population, and demographic and health information of their children were collected. Read More

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http://dx.doi.org/10.1080/02770903.2019.1571086DOI Listing
January 2019
2 Reads

Work-related asthma surveillance in Washington State: time trends, industry rates, and workers' compensation costs, 2002-2016.

J Asthma 2019 Jan 31:1-10. Epub 2019 Jan 31.

a Washington State Department of Labor and Industries , Safety and Health Assessment and Research for Prevention (SHARP) , Olympia , Washington, USA.

Objective: Washington State's work-related asthma (WRA) surveillance program utilizes workers' compensation (WC) data as its primary data source and has spanned a 15-year time period. This study analyses trends for WRA claim incidence rates compared to all WC claim incidence rates. WRA claim incidence rates and WC costs are analyzed by industry. Read More

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http://dx.doi.org/10.1080/02770903.2019.1571084DOI Listing
January 2019
1 Read

A comparison of characteristics and outcomes of patients admitted to the ICU with asthma in Australia and New Zealand and United states.

J Asthma 2019 Jan 31:1-7. Epub 2019 Jan 31.

g Centre for Outcome and Resource Evaluation , Australian and New Zealand Intensive Care Society , Melbourne , Australia.

Objective: To compare the characteristics, use of invasive ventilation and outcomes of patients admitted with critical asthma syndrome (CAS) to ICUs in Australia and New Zealand (ANZ), and a large cohort of ICUs in the United States (US).

Methods: We examined two large databases of ICU for patients admitted with CAS in 2014 and 2015. We obtained, analyzed, and compared information on demographic and physiological characteristics, use of invasive mechanical ventilation, and clinical outcome and derived predictive models. Read More

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http://dx.doi.org/10.1080/02770903.2019.1571082DOI Listing
January 2019

Outpatient pulmonary rehabilitation for severe asthma with fixed airway obstruction: Comparison with COPD.

J Asthma 2019 Jan 29:1-9. Epub 2019 Jan 29.

h Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, DHU FIRE, Service de Pneumologie, INSERM UMR1152, Université Paris Diderot, Labex Inflamex, Paris, France.

Background: The benefit of exercise has been demonstrated in asthma, but the role of pulmonary rehabilitation (PR) in people with severe asthma, especially with airway obstruction, has been less investigated. The activity limitation mechanisms differ in asthma and COPD, so the effect of a PR program not specific to asthma is unclear.

Methods: We retrospectively compared the effect of an ambulatory PR program in nonsmoking patients with severe asthma and airway obstruction (FEV1/FVC ratio <70% and FEV1 < 80% measured twice, not under an exacerbation) and sex-, age-, FEV1-, and BMI-matched COPD controls. Read More

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http://dx.doi.org/10.1080/02770903.2018.1541351DOI Listing
January 2019
1 Read

Reducing pediatric asthma hospital length of stay through evidence-based quality improvement and deployment of computerized provider order entry.

J Asthma 2019 Jan 25:1-13. Epub 2019 Jan 25.

b CHRISTUS Health Santa Rosa and Baylor College of Medicine, Department of Pediatrics , Children's Hospital of San Antonio , San Antonio , TX , USA.

Objective: Evaluate the impact of multi-component quality improvement for pediatric asthma care focusing on serial use of an evidence-based clinical pathway via paper order sets, pathway integration into computerized provider order entry (CPOE), use of a clinical respiratory score (CRS) and a discharge checklist.

Methods: Outcomes were assessed over three intervention periods and 50 months on: time to beta-agonist and steroid first administration, frequency of readmissions and hospital length of stay. A general linear model estimated mean log(LOS) over time and between study periods. Read More

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http://dx.doi.org/10.1080/02770903.2018.1553053DOI Listing
January 2019

Asthma management in school: parents' and school personnel perspectives.

J Asthma 2019 Jan 24:1-11. Epub 2019 Jan 24.

a Asthma Center , Connecticut Children's Medical Center , Hartford , CT , USA.

Objective: Effective asthma management at school can help students with asthma stay healthy, learn better and participate fully during their school day. This study sought to understand school-based asthma care from the perspective of parents and school personnel to improve asthma care at school.

Methods: A cross-sectional study was conducted in Hartford, CT. Read More

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http://dx.doi.org/10.1080/02770903.2019.1568455DOI Listing
January 2019

It takes a village - asthma networks utilized by parents when managing childhood asthma medications.

J Asthma 2019 Jan 22:1-13. Epub 2019 Jan 22.

a Sydney Medical School, Faculty of Medicine and Health , The University of Sydney , Sydney , Australia.

Objective: We are yet to understand how widely parents seek asthma medication management information for their children, how they are used for health information, how parents engage with them and their influence on parent's decision-making. This study aimed to gauge the current level of asthma knowledge and skills of parents of children with asthma and gain insight into who and what influences their child's asthma medication management decisions.

Method: Social network theory was used to map parents' asthma networks and identify the level of influence of each individual/resource nominated. Read More

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http://dx.doi.org/10.1080/02770903.2019.1568456DOI Listing
January 2019

Interactive effects of family functioning and sleep experiences on daily lung functioning in pediatric asthma: An ecological momentary assessment approach.

J Asthma 2019 Jan 22:1-9. Epub 2019 Jan 22.

a Virginia Commonwealth University , Richmond , VA , USA.

Objectives: Children living in urban, underserved settings are at risk for experiencing sleep difficulties as well as poor asthma outcomes. The family is important for both asthma management and ensuring children are getting the necessary amount of sleep, but how family functioning and sleep patterns influence children's asthma remains unclear.

Methods: Fifty-nine children (7-12 years old; 90% African American) diagnosed with asthma, and their primary caregivers, participated in this study. Read More

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http://dx.doi.org/10.1080/02770903.2019.1568453DOI Listing
January 2019

Disparate diagnostic accuracy of lung function tests as predictors of poor asthma control in children.

J Asthma 2019 Jan 21:1-8. Epub 2019 Jan 21.

c Child Health Research Center, Department of Pediatrics , University of Virginia School of Medicine , Charlottesville , VA , USA.

Rationale: In practice, asthma control is assessed according to symptom burden and office spirometry. However, spirometry poorly tests peripheral lung function, which may be abnormal in asthma. Impluse oscillometry (IOS) and multiple-breath washout (MBW) are novel methods which measure reactance (X5) and ventilation heterogeneity (VH) in the peripheral lung, but how well these tests reflect asthma control is poorly understood. Read More

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http://dx.doi.org/10.1080/02770903.2019.1566471DOI Listing
January 2019
3 Reads

Patients' adherence-related beliefs about inhaled steroids: application of the Chinese version of the Beliefs about Medicines Questionnaire-specific in patients with asthma.

J Asthma 2019 Jan 21:1-8. Epub 2019 Jan 21.

a Department of Pharmacy , Zhongshan Hospital, Fudan University , Shanghai , PR China.

Objective: The main objective of the present study is to evaluate the psychometric properties of the Chinese version of Beliefs about Medicines Questionnaire-specific among asthma patients; and to assess the association between patients' belief and adherence to inhaled corticosteroid therapy.

Methods: A cross-sectional survey was carried out in the asthma clinic of Zhongshan Hospital, to Fudan University (Shanghai, China) between April 2016 and March 2018. The Beliefs about Medicines Questionnaire-specific was translated into Chinese according to international guidelines. Read More

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http://dx.doi.org/10.1080/02770903.2019.1565824DOI Listing
January 2019
6 Reads

Adherence stages measured by patient-reported outcome instruments in adults with asthma: a scoping review.

J Asthma 2019 Jan 21:1-9. Epub 2019 Jan 21.

d CHU de Quebec - Laval University Research Center, Population Health and Optimal Health Practices Research Unit , Quebec City , Quebec , Canada.

Objective: Individuals who are adherent to their asthma inhaled maintenance medication: (1) initiate their treatment (take the first dose); (2) implement it (take it as per prescribed dosing regimen); and persist with it (take it for the entire prescribing period). To avoid unnecessary hospitalizations and costs, patient adherence should be routinely assessed. To this end, we aimed to identify patient-reported outcome instruments (PROs) used for measurement of patient adherence to inhaled maintenance medication in asthmatic adults and to report on the adherence stage that these instruments measured. Read More

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http://dx.doi.org/10.1080/02770903.2019.1565823DOI Listing
January 2019
2 Reads

Community Asthma Initiative: Cost Analyses using Claims Data from a Medicaid Managed Care Organization.

J Asthma 2019 Jan 21:1-9. Epub 2019 Jan 21.

b Division of Adolescent/Young Adult Medicine , Boston Children's Hospital , Boston , MA , USA.

Objective: Use claims data to examine the cost benefit of the Community Asthma Initiative (CAI), a Boston area nurse-supervised community health worker (CHW) asthma home-visiting program.

Methods: The reduction in asthma treatment costs was assessed using Massachusetts claims data from one Medicaid Managed Care Organization (MCO) in the north east that included all costs between January 1, 2011 and December 31, 2016. The data was used to determine asthma-related utilization cost reductions between 1 year pre- and 1, 2 and 3 years post-intervention. Read More

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http://dx.doi.org/10.1080/02770903.2019.1565825DOI Listing
January 2019
2 Reads

Asthma specialist care preferences among parents of children receiving emergency department care for asthma.

J Asthma 2019 Jan 21:1-8. Epub 2019 Jan 21.

d Department of Pediatrics , The David Geffen School of Medicine at UCLA , Los Angeles , CA , USA.

Objective: To learn factors associated with desire for asthma specialist care among parents of children seeking emergency department (ED) care for asthma, and if referral was indicated based on national asthma guidelines.

Methods: We surveyed parents of children ages 0-18 years seeking pediatric ED asthma care, then comparisons were made according to parental level of interest in asthma specialist care, with regard to socio-demographics, asthma morbidity and care, by chi-squared and logistic regression.

Results: Of 149 children, 20% reported specialist care, but 75% met guideline criteria for referral. Read More

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http://dx.doi.org/10.1080/02770903.2019.1565768DOI Listing
January 2019
2 Reads

Association of asthma and sleep insufficiency among South Korean adolescents: analysis of web-based self-reported data from the Korean youth risk behavior web-based survey.

J Asthma 2019 Jan 18:1-9. Epub 2019 Jan 18.

b Division of Pulmonology, Department of Internal Medicine , International St. Mary`s Hospital , Catholic Kwandong University College of Medicine , Incheon , Republic of Korea.

Objectives: Weekend oversleep or catch-up sleep is common among adolescents, but relatively few data are available with regard to its effects on asthma. Our aim was to investigate whether weekend oversleep is associated with ever having asthma among Korean adolescents.

Methods: We analyzed web-based self-reported data from the Korean Youth Risk Behavior Web-based Survey in 25,927 physician-diagnosed adolescent asthma cases and 266,160 non-asthma cases. Read More

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http://dx.doi.org/10.1080/02770903.2019.1565827DOI Listing
January 2019

Documentation of asthma control and severity in pediatrics: analysis of national office-based visits.

J Asthma 2019 Jan 18:1-12. Epub 2019 Jan 18.

a Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy , University of Houston , TX , USA.

Objective: To evaluate the extent of documentation of asthma control and severity and associated characteristics among pediatric asthma patients in office-based settings.

Methods: This cross-sectional study utilized data from the 2012-2015 National Ambulatory Medical Care Survey (NAMCS). Patients aged 6-17 years with a diagnosis of asthma were included. Read More

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http://dx.doi.org/10.1080/02770903.2018.1554069DOI Listing
January 2019

Missing asthma patients in epidemiologic survey?

J Asthma 2019 Jan 18:1-2. Epub 2019 Jan 18.

a Facultad de Ciencias de la Salud , Universidad Peruana de Ciencias Aplicadas , Lima , Perú.

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http://dx.doi.org/10.1080/02770903.2019.1565767DOI Listing
January 2019

Asthma in the older adult.

J Asthma 2019 Jan 18:1-12. Epub 2019 Jan 18.

i Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago , Chicago , IL , USA.

Objective: The older adult population is increasing worldwide, and a significant percentage has asthma. This review will discuss the challenges to diagnosis and management of asthma in older adults.

Data Sources: PubMed was searched for multiple terms in various combinations, including asthma, older adult, elderly, comorbid conditions, asthma diagnosis, asthma treatment, biologics and medication side effects, and adverse events. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2019.1
Publisher Site
http://dx.doi.org/10.1080/02770903.2019.1565828DOI Listing
January 2019
4 Reads

Impact of moderate-severe persistent allergic rhinitis on thoraco-abdominal kinematics and respiratory muscle function.

J Asthma 2019 Jan 18:1-7. Epub 2019 Jan 18.

c Postgraduate Program in Health Sciences , Recife , Brazil.

Objective: To assess thoraco-abdominal kinematics, respiratory muscle strength and electromyographic activity of the diaphragm (EAdi) in moderate-severe allergic rhinitis (AR) patients.

Methods: A cross-sectional study involving 40 individuals (20 in the AR group) and 20 in the control group [CG]) was conducted. Ventilatory pattern and chest wall volume distribution (optoelectronic plethysmography), respiratory muscle strength (manovacuometry and sniff nasal inspiratory pressure [SNIP]), and EAdi were assessed in both groups. Read More

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http://dx.doi.org/10.1080/02770903.2018.1543433DOI Listing
January 2019
1 Read

Association between probiotic supplementation and asthma incidence in infants: a meta-analysis of randomized controlled trials.

J Asthma 2019 Jan 18:1-12. Epub 2019 Jan 18.

a Department of Pharmacy , Tianjin First Central Hospital , Tianjin , People's Republic of China.

Objective: The increased social and economic burdens for asthma in infants make the prevention of asthma a major public health goal. Probiotics may reduce the risk of asthma in infants. However, randomized controlled trials (RCTs) have shown mixed efficacy outcomes. Read More

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http://dx.doi.org/10.1080/02770903.2018.1561893DOI Listing
January 2019

The role of self-efficacy and locus of control in asthma-related needs and outcomes: a cross-sectional study.

J Asthma 2019 Jan 11:1-9. Epub 2019 Jan 11.

a Institute of Occupational Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine , University of Düsseldorf , Düsseldorf , Germany.

Objective: This study sought to identify psychological resources, which are associated with improved asthma outcomes.

Methods: A total of 205 patients who reported physician-diagnosed asthma were surveyed between September 2017 and March 2018. Psychological resources included self-efficacy (i. Read More

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http://dx.doi.org/10.1080/02770903.2018.1556687DOI Listing
January 2019

Effect of nintedanib on airway inflammation in a mouse model of acute asthma.

J Asthma 2019 Jan 11:1-10. Epub 2019 Jan 11.

a Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine , The Catholic University of Korea , Seoul , Republic of Korea.

Objective: New treatments are needed for cases of asthma that are refractory to traditional therapies. In this study, we examined the effect of oral nintedanib, an intracellular inhibitor of tyrosine kinases, on airway hyper-responsiveness (AHR) and airway smooth muscle cells, using a mouse model of experimental asthma.

Methods: Asthma was experimentally induced in mice via subcutaneous injection of ovalbumin (OVA). Read More

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http://dx.doi.org/10.1080/02770903.2018.1544641DOI Listing
January 2019

Modulation of the airway smooth muscle phenotype in a murine asthma model and effects of nuclear factor-κB inhibition.

J Asthma 2019 Jan 11:1-10. Epub 2019 Jan 11.

a Department of Respiratory Diseases , Second Clinical medical college (Shenzhen People's Hospital), Jinan University , Shenzhen , China.

Objective: Phenotype modulation of airway smooth muscle (ASM) is a unique characteristic of asthma and is considered to regulate airway remodeling, airway hyperresponsiveness (AHR) and inflammation. The nuclear factor-κB (NF-κB) signaling pathway plays a crucial role in phenotypic modulation. Thus, models of acute and chronic asthma were established and pyrrolidine dithiocarbamate (PDTC), an NF-κB inhibitor was delivered by intraperitoneal injection. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2018.1
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http://dx.doi.org/10.1080/02770903.2018.1539498DOI Listing
January 2019
9 Reads
1.828 Impact Factor

Prevalence and determinants of asthma among aboriginal adolescents in Canada.

J Asthma 2019 Jan 10:1-7. Epub 2019 Jan 10.

a Canadian Centre for Health and Safety in Agriculture , University of Saskatchewan , Saskatoon , Saskatchewan , Canada.

Objective: The objective of the study was to determine the prevalence and associated risk factors of asthma in Aboriginal adolescents in Canada based on the Canadian Aboriginal Peoples Survey (APS) 2012. Few studies have investigated the prevalence and risk factors of asthma in Aboriginal adolescents in Canada.

Methods: Data from the cross-sectional APS 2012 were analyzed to accomplish the objective. Read More

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http://dx.doi.org/10.1080/02770903.2018.1541354DOI Listing
January 2019
1 Read

Epidural pneumorrhachis, a rare complication of asthma exacerbation.

J Asthma 2019 Jan 10:1-4. Epub 2019 Jan 10.

a Servicio de Alergia e Inmunología Clínica, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca" , Guadalajara , Jalisco , México.

Introduction: An association between pneumorrhachis and asthma exacerbation is uncommon. However, we present a clinical case involving a patient with exacerbated asthma, subcutaneous emphysema, spontaneous pneumomediastinum (SPM), and pneumorrhachis.

Case Study: The patient was an 18-year-old male with asthma since childhood who only relied on salbutamol to control his asthma symptoms. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2018.1
Publisher Site
http://dx.doi.org/10.1080/02770903.2018.1539101DOI Listing
January 2019
4 Reads

Associations between asthma and body weight misconceptions among South Korean adolescents: Nationwide cross-section study.

J Asthma 2019 Jan 1:1-8. Epub 2019 Jan 1.

b Department of Internal Medicine , International St. Mary`s Hospital, Catholic Kwandong University College of Medicine , Incheon , Republic of Korea.

Objectives: As the numbers of adolescents with asthma are increasing, appropriate recognition of the importance of body weight is necessary. This study explored body weight misconceptions and related factors in adolescent asthma patients.

Methods: Web-based self-reported data from the Korean Youth Risk Behavior Web-Based Survey of 60,974 physician-diagnosed adolescents with asthma were used in this study. Read More

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http://dx.doi.org/10.1080/02770903.2018.1541355DOI Listing
January 2019

Effectiveness and safety of omalizumab in severe, persistent IgE-mediated asthma in pediatric and adult patients: a real-world observational study in Egyptian population.

J Asthma 2018 Dec 28:1-7. Epub 2018 Dec 28.

d Novartis Pharma S.A.E. , Cairo , Egypt.

Objective: Real-world studies on the effectiveness of omalizumab in Egyptian population with asthma are limited. This study aimed to evaluate the real-world effectiveness and safety of omalizumab as an add-on treatment in pediatric and adult patients with severe, persistent allergic asthma in Egypt.

Methods: The primary endpoint of this 16-week, prospective, open-label, multicenter, non-interventional study was the reduction in oral corticosteroid (OCS) dose. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2018.1
Publisher Site
http://dx.doi.org/10.1080/02770903.2018.1553051DOI Listing
December 2018
6 Reads
1.828 Impact Factor

Comparisons between 2015 US asthma prevalence and two measures of asthma burden by racial/ethnic group.

J Asthma 2018 Dec 28:1-11. Epub 2018 Dec 28.

b Department of Biostatistics , Michigan School of Public Health , Ann Arbor , Michigan , USA.

Objective: Asthma affects approximately 20,383,000 Americans and costs the US $56 billion dollars annually. Asthma burden is not uniform across different racial/ethnic groups. Although annual asthma prevalences by racial/ethnic group are provided by the CDC, these numbers do not account for the influence of other sociodemographic and clinical factors. Read More

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http://dx.doi.org/10.1080/02770903.2018.1556686DOI Listing
December 2018

Expression of TSLP and IL-33 receptors on sputum macrophages of asthma patients and healthy subjects.

J Asthma 2018 Dec 27:1-10. Epub 2018 Dec 27.

a Department of Internal Medicine, Pulmonary Diseases and Allergy , Medical University of Warsaw , Warsaw , Poland.

Objective: Local cytokine milieu (especially Th2 inflammatory type) secreted into the asthmatic airways affect the alternative activated macrophages polarization (M2). TSLP and IL-33 are important alarmins of allergic response associated with Th2 inflammation. The aim of the study was to investigate the expression of the receptors for epithelial derived cytokines: TSLP (TSLPR) and IL-33 (ST2) on induced sputum CD206 positive macrophages from asthma and healthy subjects and analyze the relationships between these receptors and clinical features of the disease. Read More

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http://dx.doi.org/10.1080/02770903.2018.1543435DOI Listing
December 2018

Non-pharmacological management of adult asthma in Australia: cross-sectional analysis of a population-based cohort study.

J Asthma 2018 Dec 20:1-8. Epub 2018 Dec 20.

a Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health , University of Melbourne , Melbourne , Victoria , Australia.

Aim: To identify the level of non-pharmacological care received by middle-aged adults with current asthma in Australia and to identify its association with clinical measures.

Methods: The Tasmanian Longitudinal Health Study (TAHS) is a population-based cohort first studied in 1968 (n = 8583). In 2010, when participants were aged 49 years, a stratified sample enriched for asthma and bronchitis underwent clinical assessments including respiratory questionnaires and lung function testing (n = 836). Read More

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http://dx.doi.org/10.1080/02770903.2018.1545030DOI Listing
December 2018
1 Read

Sleep hygiene in adolescents with asthma.

J Asthma 2018 Dec 13:1-9. Epub 2018 Dec 13.

a Department of Clinical and Health Psychology , University of Florida , Gainesville , FL , USA.

Objective: Youth with asthma are at-risk for sleep difficulties due to nocturnal asthma symptoms. Sleep hygiene, or the ability to practice consistent sleep behaviors and habits, impacts youth sleep quality and may, as a result, influence daytime cognitive functioning. The current study sought to examine the impact sleep hygiene has on sleep quality, health-related quality of life (HRQL) and sustained attention among adolescents with asthma. Read More

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http://dx.doi.org/10.1080/02770903.2018.1553049DOI Listing
December 2018

Cost-effectiveness of omalizumab for the treatment of inadequately controlled severe allergic asthma in Chinese children.

J Asthma 2018 Dec 3:1-8. Epub 2018 Dec 3.

a Department of VIP, Shanghai Children's Hospital, affiliated with the School of Medicine , Shanghai Jiaotong University , Shanghai , China.

Objective: The addition of omalizumab to standard therapy has proven to be efficacious in children with severe allergic asthma. The goal of this study was to assess the cost-effectiveness of adding omalizumab to standard treatment for asthma in Chinese pediatric patients.

Methods: A Markov model was constructed to project the health and economic outcomes in pediatric patients with severe allergic asthma. Read More

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http://dx.doi.org/10.1080/02770903.2018.1544642DOI Listing
December 2018

Patients' drawings of their asthma: adding qualitative specificity to a quantitative measure of illness perceptions.

J Asthma 2018 Dec 3:1-10. Epub 2018 Dec 3.

a The University of Sydney School of Pharmacy, Faculty of Medicine and Health , The University of Sydney , Camperdown , Australia.

Objective: Patients' perceptions about their asthma can influence behavior, coping and outcomes. Previous studies have also identified that patients' views can differ significantly to that of healthcare professionals. Enhancing current understanding of patients' perceptions can assist in reducing this mismatch. Read More

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http://dx.doi.org/10.1080/02770903.2018.1541358DOI Listing
December 2018

A systematic review of the adverse events and economic impact associated with oral corticosteroids in asthma.

J Asthma 2018 Dec 4:1-13. Epub 2018 Dec 4.

a Faculty of Medicine, Division of Respiratory Medicine , UBC , Vancouver , Canada.

Background: Oral corticosteroids (OCSs) are often used to achieve asthma control. OCS-related comorbidities increase the burden of disease for patients and healthcare providers. Most studies characterizing OCS use and risk of adverse events (AEs) are in non-asthma patients. Read More

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http://dx.doi.org/10.1080/02770903.2018.1539100DOI Listing
December 2018
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Association of upper and lower airway eosinophilic inflammation with response to omalizumab in patients with severe asthma.

J Asthma 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Department of Respiratory Medicine and Infectious Diseases , Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan.

Background: The anti-immunoglobulin E monoclonal antibody, omalizumab, is used to treat severe asthma and has the potential to ameliorate airway inflammation. However, the effect of omalizumab in ameliorating upper airway inflammation has not been fully elucidated.

Objective: We investigated the association of upper and lower airway inflammation with the response to omalizumab treatment. Read More

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http://dx.doi.org/10.1080/02770903.2018.1541357DOI Listing
November 2018
1 Read

Measurement of FeNO with a portable, electrochemical analyzer using a 6-second exhalation time in 7-10-year-old children with asthma: comparison to a 10-second exhalation.

J Asthma 2018 Nov 19:1-6. Epub 2018 Nov 19.

a Circassia Pharmaceuticals Inc , Morrisville , NC , USA.

Objective: Fractional exhaled nitric oxide (FeNO) is a valuable tool for assessing Th2 inflammation in children with asthma. Exhalation times of 6 and 10 s meet the current recommendations for assessing FeNO. The 6-s exhalation provides an alternative for 7-10 year olds not able to complete the 10-s exhalation. Read More

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http://dx.doi.org/10.1080/02770903.2018.1541350DOI Listing
November 2018

Weight-management in children living with asthma: a qualitative study of the experiences of paediatric healthcare professionals.

J Asthma 2018 Nov 16:1-8. Epub 2018 Nov 16.

a Department of Psychology , Aston University , Birmingham , UK.

Objective: Weight loss has been found to improve the symptoms of asthma in children who are overweight. However, many paediatric weight management programmes do not address the challenges associated with living with asthma. The aim of this study was to explore the views and experiences of paediatric healthcare professionals concerning weight management advice and support offered to families of children living with asthma. Read More

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http://dx.doi.org/10.1080/02770903.2018.1536146DOI Listing
November 2018
8 Reads

Safety profile of the SQ house dust mite sublingual immunotherapy-tablet in Japanese adult patients with house dust mite-induced allergic asthma: a randomized, double-blind, placebo-controlled phase I study.

J Asthma 2018 Nov 16:1-9. Epub 2018 Nov 16.

c Department of Medicine, Division of Respiratory Medicine and Allergology , School of Medicine, Showa University , Tokyo , Japan.

Objective: The SQ house dust mite (HDM) sublingual immunotherapy (SLIT)-tablet has demonstrated effective treatment of HDM-induced allergic asthma in patients 18 years or older in European trials. This study investigated its safety and immunology profile in Japanese adult patients with mild-to-moderate HDM-induced allergic asthma.

Methods: In this randomized, double-blind, placebo-controlled study, 48 Japanese patients were randomly assigned to a daily treatment of SQ HDM SLIT-tablet or placebo (3:1) for 14 d with or without an up-dosing regimen. Read More

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http://dx.doi.org/10.1080/02770903.2018.1541353DOI Listing
November 2018
10 Reads

Anti-interleukin (IL)-5 as a steroid-sparing agent in chronic eosinophilic pneumonia.

J Asthma 2018 Nov 16:1-5. Epub 2018 Nov 16.

c Medicine , University at Buffalo , Buffalo , New York , USA.

Introduction: Anti-interleukin (IL)-5 therapy is a novel drug class clinically effective in patients with diverse eosinophil-related disorders such as allergic eosinophilic asthma, eosinophilic granulomatosis with polyangiitis (EGPA), nasal polyposis, eosinophilic COPD, and other non-pulmonary disorders such as eosinophilic esophagitis. Chronic eosinophilic pneumonia (CEP) is a steroid responsive disorder, however, relapses are common following corticosteroid tapering.

Case Study: We present the case of a 42-year-old woman with steroid-dependent relapsing CEP successfully treated with anti-IL-5 antibody. Read More

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http://dx.doi.org/10.1080/02770903.2018.1543434DOI Listing
November 2018
1 Read