3,343 results match your criteria Journal of Applied Toxicology [Journal]


Acute kidney injury model established by systemic glutathione depletion in mice.

J Appl Toxicol 2019 Feb 15. Epub 2019 Feb 15.

Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Glutathione (GSH) is one of the most extensively studied tripeptides. The roles for GSH in redox signaling, detoxification of xenobiotics and antioxidant defense have been investigated. A drug-induced rhabdomyolysis mouse model was recently established in L-buthionine-(S,R)-sulfoximine (BSO; a GSH synthesis inhibitor)-treated normal mice by co-administration of antibacterial drug and statin. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3780
Publisher Site
http://dx.doi.org/10.1002/jat.3780DOI Listing
February 2019
4 Reads

Predicting the cytotoxicity of chemicals using ensemble learning methods and molecular fingerprints.

J Appl Toxicol 2019 Feb 14. Epub 2019 Feb 14.

School of Life Science, Liaoning University, Shenyang, 110036, China.

The prediction of compound cytotoxicity is an important part of the drug discovery process. However, it usually appears as poor predictive performance because the datasets are high-throughput and have a class-imbalance problem. In this study, several strategies of performing a structure-activity relationship study for a cytotoxic endpoint in the AID364 dataset were explored to solve the class-imbalance problem. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3785DOI Listing
February 2019

In vitro genotoxicity assessment of nickel(II) oxide nanoparticles on lymphocytes of human peripheral blood.

J Appl Toxicol 2019 Feb 14. Epub 2019 Feb 14.

Toxicology Lab, Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India.

The current study was intended to elucidate the cytotoxicity, genotoxicity ability of nickel oxide (NiO) nanoparticles (NPs) and assessment of preliminary mechanism of the toxicity. Characterization studies showed that NiO-NPs have a particle size of 17.94 (±3. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3784
Publisher Site
http://dx.doi.org/10.1002/jat.3784DOI Listing
February 2019
4 Reads

Direct activation of aryl hydrocarbon receptor by benzo[a]pyrene elicits T-helper 2-driven proinflammatory responses in a mouse model of allergic dermatitis.

J Appl Toxicol 2019 Feb 12. Epub 2019 Feb 12.

Toxicology Division, Institute of Environmental Toxicology, 4321, Uchimoriya-machi, Joso-shi, Ibaraki, 303-0043, Japan.

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to various environmental chemicals and contributes to numerous toxicological effects. However, the direct effects of AhR on the development of allergic diseases are not fully understood. The main aim of this study was to elucidate the action of AhR in the development of cutaneous allergies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3782DOI Listing
February 2019

Effect of chronic exposure to inorganic arsenic on intestinal cells.

J Appl Toxicol 2019 Feb 12. Epub 2019 Feb 12.

Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Calle Agustín Escardino 7, 46980, Paterna, Valencia, Spain.

Chronic exposure to inorganic arsenic (As)-As(III) + As(V)-is associated with type 2 diabetes, vascular diseases and various types of cancer. Although the oral route is the main way of exposure to inorganic As, the adverse gastrointestinal effects produced by chronic exposure are not well documented. The aim of the present study is to evaluate the effect of chronic exposure to As(III) on the intestinal epithelium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3778DOI Listing
February 2019

Dietary cadmium exposure and renal dysfunction: A risk estimation.

Authors:
Tomoyuki Kawada

J Appl Toxicol 2019 Feb 12. Epub 2019 Feb 12.

Department of Hygiene and Public Health, Nippon Medical School, Tokyo, 113-8602, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3781DOI Listing
February 2019

Benzo fury: A new trend in the drug misuse scene.

J Appl Toxicol 2019 Feb 5. Epub 2019 Feb 5.

UCIBIO, REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal.

Benzofurans, also known by users as benzo fury or benzofury, are synthetic phenethylamines and constitute the third most prominent group of new psychoactive substances (NPS). As the use of these substances has been spread as an alternative to the classic illicit psychostimulants, such as amphetamines, their legal status was reviewed, resulting in an utter prohibition of these NPS in many countries worldwide. Herein, the prevalence of abuse, chemistry, biological effects, metabolism, and the potential harms and risky behaviors associated with the abuse of benzofurans are reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3774DOI Listing
February 2019
1 Read

Genotoxic effects of silver nanoparticles with/without coating in human liver HepG2 cells and in mice.

J Appl Toxicol 2019 Jan 31. Epub 2019 Jan 31.

Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, 210009, China.

With the rapid expansion of human exposure to silver nanoparticles (AgNPs), the genotoxicity screening is critical to the biosafety evaluation of nanosilver. This study assessed DNA damage and chromosomal aberration in the human hepatoma cell line (HepG2) as well as the effects on the micronucleus of bone marrow in mice induced by 20 nm polyvinylpyrrolidone-coated nanosilver (PVP-AgNPs) and 20 nm bare nanosilver (AgNPs). Our results showed that the two types of AgNPs, in doses of 20-160 μg/mL, could cause genetic toxicological changes on HepG2 cells. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3779
Publisher Site
http://dx.doi.org/10.1002/jat.3779DOI Listing
January 2019
14 Reads

Immunohistochemistry of γ-H2AX as a method of early detection of urinary bladder carcinogenicity in mice.

J Appl Toxicol 2019 Jan 31. Epub 2019 Jan 31.

Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan.

Phosphorylated histone H2AX (γ-H2AX) has been demonstrated as a DNA damage marker both in vitro and in vivo. We previously reported the effects of genotoxic carcinogens in the urinary bladder of rats by immunohistochemical analysis of γ-H2AX using samples from 28-day repeated-dose tests. To evaluate the application of γ-H2AX as a biomarker of carcinogenicity in the bladder, we examined species differences in γ-H2AX formation in the urinary bladder of mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3775DOI Listing
January 2019

Role of iron and oxidative stress in the exacerbation of allergic inflammation in murine lungs caused by urban particulate matter <2.5 μm and desert dust.

J Appl Toxicol 2019 Jan 30. Epub 2019 Jan 30.

Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA.

Simultaneous exposure of lipopolysaccharide (LPS) and urban particulate matter <2.5 μm (PM2.5) or desert dust exacerbated murine asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3773DOI Listing
January 2019
1 Read

The neonicotinoids acetamiprid and imidacloprid impair neurogenesis and alter the microglial profile in the hippocampal dentate gyrus of mouse neonates.

J Appl Toxicol 2019 Jan 29. Epub 2019 Jan 29.

Laboratory of Developmental Biology, Department of Life Science, Kindai University, 3-4-1 Kowakae, Higashiosaka, Osaka, 577-8502, Japan.

Acetamiprid (ACE) and imidacloprid (IMI) are widely used neonicotinoid pesticides. They bind selectively to insect nicotinic acetylcholine receptors (nAChRs) and are considered non-hazardous to mammals. Few studies have assessed the activation of vertebrate nAChRs and the neurodevelopmental toxicity following in utero or neonatal exposure to neonicotinoids; therefore, we evaluated the effects of ACE or IMI exposure on neurogenesis and microglial profiles in the developing hippocampal dentate gyrus (DG) of mouse neonates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3776DOI Listing
January 2019
1 Read

Electronic cigarette liquid exposure induces flavor-dependent osteotoxicity and increases expression of a key bone marker, collagen type I.

J Appl Toxicol 2019 Jan 28. Epub 2019 Jan 28.

Department of Biology, The College of Idaho, 2112 Cleveland Blvd, Caldwell, ID, 83605, USA.

Electronic cigarettes (e-cigarettes) are nicotine delivery devices advertised as a healthier alternative to conventional tobacco products, but their rapid rise in popularity outpaces research on potential health consequences. As conventional tobacco use is a risk factor for osteoporosis, this study examines whether exposure to electronic liquid (e-liquid) used in e-cigarettes affects bone-forming osteoblasts. Human MG-63 and Saos-2 osteoblast-like cells were treated for 48 hours with 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3777DOI Listing
January 2019

In silico prediction of chemical reproductive toxicity using machine learning.

J Appl Toxicol 2019 Jan 27. Epub 2019 Jan 27.

Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.

Reproductive toxicity is an important regulatory endpoint in health hazard assessment. Because the in vivo tests are expensive, time consuming and require a large number of animals, which must be killed, in silico approaches as the alternative strategies have been developed to assess the potential reproductive toxicity (reproductive toxicity) of chemicals. Some prediction models for reproductive toxicity have been developed, but most of them were built only based on one single endpoint such as embryo teratogenicity; therefore, these models may not provide reliable predictions for toxic chemicals with other endpoints, such as sperm reduction or gonadal dysgenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3772DOI Listing
January 2019
2.982 Impact Factor

Exposure to cadmium and mono-(2-ethylhexyl) phthalate induce biochemical changes in rat liver, spleen, lung and kidney as determined by attenuated total reflection-Fourier transform infrared spectroscopy.

J Appl Toxicol 2019 Jan 25. Epub 2019 Jan 25.

Department of Andrology, Shiyan Renmin Hospital, Hubei University of Medicine, Shiyan, China.

Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy is a label-free, non-destructive analytical technique for biochemical analysis of macromolecular components within tissue samples. Cadmium (Cd) and mono-(2-ethylhexyl) phthalate (MEHP), a primary metabolite of di-(2-ethylhexyl) phthalate, are present ubiquitously in the environment and in organisms, and have adverse impacts on ecosystems and human health. Herein we employed ATR-FTIR analysis to identify biomolecular changes in rat liver, spleen, lung and kidney after prepubertal exposure to Cd and MEHP. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3767
Publisher Site
http://dx.doi.org/10.1002/jat.3767DOI Listing
January 2019

Effect of arsenic exposure on early eye development in zebrafish (Danio rerio).

J Appl Toxicol 2019 Jan 22. Epub 2019 Jan 22.

School of Marine Sciences, University of Maine, Orono, ME, USA.

Arsenic is a metalloid that contaminates drinking water supplies worldwide. Owing to concerns for human health, the World Health Organization and the US Environmental Protection Agency have established a safe level in drinking water of ≤10 ppb. Recently, arsenic exposure has also been linked to lower IQ values in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3770DOI Listing
January 2019

Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells.

J Appl Toxicol 2019 Jan 22. Epub 2019 Jan 22.

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Northeast Agricultural University Harbin, People's Republic of China.

This study investigated the pharmacological inhibition of the toll-like receptor 4 (TLR4) genes as a measure to attenuate microcystin-LR (MC-LR) reproductive toxicity. Bovine Sertoli cells were pretreated with TLR4-IN-C34 (C34) for 1 hour. Thereafter the pretreated and non-pretreated Sertoli cells were cultured in medium containing 10% heat-activated fetal bovine serum + 80 μg/L MC-LR for 24 hours to assess the ability of TLR4-IN-C34 to attenuate the toxic effects of MC-LR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3771DOI Listing
January 2019
1 Read

Gender difference in hepatic toxicity of titanium dioxide nanoparticles after subchronic oral exposure in Sprague-Dawley rats.

J Appl Toxicol 2019 Jan 15. Epub 2019 Jan 15.

Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, 100191, China.

Existing literature pointed out that the liver may be the target organ of toxicity induced by titanium dioxide nanoparticles (TiO NPs) via oral exposure. Gender differences in health effects widely exist and relevant toxicological research is important for safety assessment. To explore the gender susceptibility of TiO NP-induced hepatic toxicity and the underlying mechanism, we examined female and male Sprague-Dawley rats administrated with TiO NPs orally at doses of 0, 2, 10 and 50 mg/kg body weight per day for 90 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3769DOI Listing
January 2019
1 Read

Palmitate enhanced the cytotoxicity of ZnO nanomaterials possibly by promoting endoplasmic reticulum stress.

J Appl Toxicol 2019 Jan 8. Epub 2019 Jan 8.

College of Animal Science, Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production and Construction Corps, Tarim University, Xinjiang, People's Republic of China.

We recently synthesized ZnO nanomaterials (denoted as ZnO nanorods [NRs] and Mini-NRs) and suggested that their cytotoxicity could be related with the activation of endoplasmic reticulum (ER) stress apoptosis. However, in a complex biological microenvironment, the ER stress-apoptosis pathway could also be modulated by biological molecules, such as free fatty acids, leading to unpredicted biological effects. In this study, we investigated the combined toxicity of ZnO NRs/Mini-NRs and palmitate (PA) to THP-1 macrophages. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3768
Publisher Site
http://dx.doi.org/10.1002/jat.3768DOI Listing
January 2019
4 Reads

Derivation of an occupational exposure limit for diacetyl using dose-response data from a chronic animal inhalation exposure study.

J Appl Toxicol 2019 Jan 8. Epub 2019 Jan 8.

Cardno ChemRisk, Brooklyn, NY, USA.

Occupational exposure limits (OELs) have been previously proposed for diacetyl; however, most of these values are based on worker cohort studies that are known to have several limitations and confounders. In this analysis, an 8 hour time-weighted average (TWA) OEL for diacetyl was derived based on data from a chronic, 2 year animal inhalation study recently released by the US National Toxicology Program. In that study, complete histopathology was conducted on male and female mice and rats exposed to 0, 12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3757DOI Listing
January 2019
1 Read

Acute and subacute oral toxicity of copper oxide nanoparticles in female albino Wistar rats.

J Appl Toxicol 2019 Jan 7. Epub 2019 Jan 7.

Toxicology Unit, Applied Biology Division, CSIR-Indian Institute of Chemical, Technology, Hyderabad, Telangana, 500007, India.

The extensive use of copper oxide nanoparticles (CuO-NPs) in various industries and their wide range of applications have led to their accumulation in different ecological niches of the environment. This excess exposure raises the concern about its potential toxic effects on various organisms including humans. However, the hazardous potential of CuO-NPs in the literature is elusive, and it is essential to study its toxicity in different biological models. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3760
Publisher Site
http://dx.doi.org/10.1002/jat.3760DOI Listing
January 2019
4 Reads

Zinc oxide nanoparticles induced gene mutation at the HGPRT locus and cell cycle arrest associated with apoptosis in V-79 cells.

J Appl Toxicol 2019 Jan 7. Epub 2019 Jan 7.

CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, India.

In recent years, the large-scale production of ZnO nanoparticles (NPs) for various applications is increasing exponentially and may pose serious health issues when inhaled either during occupational exposure or in consumer settings. The mechanisms underlying the toxicity of NPs have recently been studied intensively. Despite the existing studies, the mutagenicity of ZnO NPs in the eukaryotic system is still unclear. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3763
Publisher Site
http://dx.doi.org/10.1002/jat.3763DOI Listing
January 2019
7 Reads

Single wall and multiwall carbon nanotubes induce different toxicological responses in rat alveolar macrophages.

J Appl Toxicol 2019 Jan 3. Epub 2019 Jan 3.

Toxicology and Molecular Biology, Institute Jean Lamour UMR 7198 du CNRS, Université de Lorraine, F-54000, Nancy, France.

Human exposure to airborne carbon nanotubes (CNT) is increasing because of their applications in different sectors; therefore, they constitute a biological hazard. Consequently, developing studies on CNT toxicity become a necessity. CNTs can have different properties in term of length, size and charge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3765DOI Listing
January 2019

Changes in antioxidant, inflammatory and metabolic markers during 1 week cultivation of human skin explants.

J Appl Toxicol 2019 Jan 3. Epub 2019 Jan 3.

Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, 775 15, Olomouc, Czech Republic.

Human skin explant (HSE) seems to be a useful model for dermatological/cosmetic testing. HSE prepared from donor superfluous skin from plastic surgery operations is cheap and easily obtainable compared to reconstructed models. The HSE use, however, may be limited by the degeneration processes during cultivation. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3766
Publisher Site
http://dx.doi.org/10.1002/jat.3766DOI Listing
January 2019
7 Reads

miR-222/GAS5 is involved in DNA damage and cytotoxic effects induced by temozolomide in T98G cell line.

J Appl Toxicol 2018 Dec 21. Epub 2018 Dec 21.

Department of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangdong Province, Guangzhou, 510515, China.

Temozolomide (TMZ), a therapeutic DNA alkylator that can cause lethal DNA damage in cancer cells, is widely used for the standard chemotherapy against glioblastoma. However, long-term treatment with TMZ often causes drug resistance and poor prognosis, the mechanism of which remains largely unclear. This study aimed to investigate the possible role of miR-222/GAS5 axis on DNA damage and cytotoxic effects induced by TMZ in glioblastoma cells (T98G). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3762
Publisher Site
http://dx.doi.org/10.1002/jat.3762DOI Listing
December 2018
1 Read

Regulation of NRF2, AP-1 and NF-κB by cigarette smoke exposure in three-dimensional human bronchial epithelial cells.

J Appl Toxicol 2018 Dec 21. Epub 2018 Dec 21.

Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi-Gakuin University, 1-100 Kusumoto, Chikusa, Nagoya, 464-8650, Japan.

Cigarette smoke (CS) is a complex mixture of chemicals and interacts with various physiological processes. We previously reported that nuclear factor erythroid 2-related factor 2 (NRF2) was the most sensitive transcription factor to aqueous CS extract (AqCSE) exposure in monolayer cultured human bronchial epithelial cell lines. Recently, in vitro three-dimensional (3D) culture models have been used to supplement pharmacological and toxicological assessments. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3761
Publisher Site
http://dx.doi.org/10.1002/jat.3761DOI Listing
December 2018
2 Reads

Comprehensive lipid profiling of bleomycin-induced lung injury.

J Appl Toxicol 2018 Dec 18. Epub 2018 Dec 18.

Department of Respirology (B2), Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, Japan.

Drug-induced lung injury is an adverse effect of drug treatment that can result in respiratory failure. Because lipid profiling could provide cutting-edge understanding of the pathophysiology of toxicological responses, we performed lipidomic analyses of drug-induced lung injury. We used a mouse model of bleomycin-induced lung injury and followed the physiological responses at the acute inflammatory (day 2), inflammatory-to-fibrosis (day 7) and fibrosis (day 21) phases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3758DOI Listing
December 2018
2 Reads

Maternal di-(2-ethylhexyl) phthalate exposure alters hepatic insulin signal transduction and glucoregulatory events in rat F male offspring.

J Appl Toxicol 2018 Dec 18. Epub 2018 Dec 18.

Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, 600 113, India.

Di-(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer with endocrine disrupting properties. Its widespread use resulted in constant human exposure including fetal development and postnatal life. Epidemiological and experimental data have shown that DEHP has a negative influence on glucose homeostasis. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3764
Publisher Site
http://dx.doi.org/10.1002/jat.3764DOI Listing
December 2018
1 Read

Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects.

J Appl Toxicol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pediatrics, University of Cincinnati College of Medicine, and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, 45229, USA.

Polychlorinated biphenyls (PCBs) are toxic environmental pollutants. Humans are exposed to PCB mixtures via contaminated food or water. PCB exposure causes adverse effects in adults and after exposure in utero. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3751DOI Listing
December 2018
1 Read

Effects of co-exposure of lipopolysaccharide and β-glucan (Zymosan A) in exacerbating murine allergic asthma associated with Asian sand dust.

J Appl Toxicol 2018 Dec 12. Epub 2018 Dec 12.

Environmental Chemistry Division, National Institute for Environmental Studies, Ibaraki, 305-8506, Japan.

During the 2000s, Asian sand dust (ASD) was implicated in the increasing prevalence of respiratory disorders, including asthma. We previously demonstrated that a fungus from ASD aerosol exacerbated ovalbumin (OVA)-induced airways inflammation. Exposure to heat-inactivated ASD (H-ASD) and either Zymosan A (ZymA, containing β-glucan) or lipopolysaccharide (LPS) exacerbated allergic airways inflammation in a mouse model, but the effects of co-exposure of LPS and β-glucan are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3759DOI Listing
December 2018

DNA damage in BV-2 cells: An important supplement to the neurotoxicity of CdTe quantum dots.

J Appl Toxicol 2018 Dec 4. Epub 2018 Dec 4.

Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, 210009, China.

Microglial cells are resident immune cells in the central nervous system. Activation of microglia as induced by CdTe quantum dots (QDs) can trigger damage to neurons. To quantify the intracellular QDs, we monitored the intracellular Cd concentration in the QD-exposed mouse microglial cells (BV-2 cell line). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3745DOI Listing
December 2018
1 Read

In vitro genotoxicity assessment of an oxidized dextrin-based hydrogel for biomedical applications.

J Appl Toxicol 2018 Nov 28. Epub 2018 Nov 28.

CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.

Hydrogels are three-dimensional, crosslinked networks of hydrophilic polymers swollen with a large amount of water or biological fluids, without dissolving. Dextrin, a low-molecular-weight carbohydrate composed by glucose residues, has been used to develop an injectable hydrogel for biomedical applications. Dextrin was first oxidized to introduce aldehyde groups, which then reticulate with adipic acid dihydrazide, forming the dextrin-based hydrogel (HG). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3754
Publisher Site
http://dx.doi.org/10.1002/jat.3754DOI Listing
November 2018
16 Reads

Cigarette smoke extract may induce lysosomal storage disease-like adverse health effects.

J Appl Toxicol 2018 Nov 28. Epub 2018 Nov 28.

Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup, Jellobuk-do, Republic of Korea.

Cigarette smoke is known to be associated with the incidence of a variety of pulmonary diseases, and alveolar macrophages are a key player in the defense mechanism against inhalable toxicants. Herein, we have found that a hydrophilic fraction in smoke extracts from 3R4F reference cigarettes (CSE) contains high concentrations of volatile substances compared to cigarette smoke condensate (amphoteric fraction). We also identified the toxic mechanism of CSE using MH-S, a mouse alveolar macrophage cell line. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3744DOI Listing
November 2018
9 Reads

The use of cobalt chloride as a chemical hypoxia model.

J Appl Toxicol 2018 Nov 28. Epub 2018 Nov 28.

Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurología (INNN), Insurgentes Sur 3877, la Fama, 14269, Tlalpan Ciudad de México, Mexico.

The use of hypoxia models in cell culture has allowed the characterization of the hypoxia response at the cellular, biochemical and molecular levels. Although a decrease in oxygen concentration is the optimal hypoxia model, the problem faced by many researchers is access to a hypoxia chamber or a CO incubator with regulated oxygen levels, which is not possible in many laboratories. Several alternative models have been used to mimic hypoxia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3749DOI Listing
November 2018

The non-steroidal anti-inflammatory drug diclofenac sodium induces abnormal embryogenesis and delayed lethal effects in early life stage zebrafish (Danio rerio).

J Appl Toxicol 2018 Nov 20. Epub 2018 Nov 20.

Graduate School of Agriculture, Ehime University, Tarumi 3-5-7, Matsuyama, 790-8566, Japan.

Diclofenac sodium, a non-steroidal anti-inflammatory drug widely used in both human and veterinary medicine, has been detected in aquatic environments; therefore, its ecotoxicological effects on aquatic organisms need to be clarified. Recently, toxicity testing using zebrafish (Danio rerio) embryos has been recommended from the point of view of animal welfare; therefore, we investigated the suitability of using sub-lethal endpoints observed during embryogenesis for predicting lethal effects in early life stage zebrafish exposed to diclofenac sodium. After exposure to diclofenac sodium (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3752DOI Listing
November 2018
1 Read

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct-[RuCl(CO)(dppb)(bipy)]PF [dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2'-bipyridine], by in vitro and in vivo assays.

J Appl Toxicol 2018 Nov 20. Epub 2018 Nov 20.

Laboratório de Mutagênese, Universidade de Franca, Pq. Universitario, CEP, 14404-600, Franca, SP, Brazil.

Considering the promising previous results of ct-[RuCl(CO)(dppb)(bipy)]PF (where dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2'-bipyridine) as an antitumor agent, novel biological assays evaluating its toxicogenic potential were performed. The genotoxicity of the compound was evaluated by the in vitro micronucleus test (V79, Chinese hamster lung fibroblasts; HepG2, hepatocellular carcinoma cells), in vivo bone marrow micronucleus test and comet assay in hepatocytes (Swiss mice). The animals were treated with 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3753DOI Listing
November 2018
7 Reads

Combined effect of titanium dioxide nanoparticles and glucose on the cardiovascular system in young rats after oral administration.

J Appl Toxicol 2018 Nov 14. Epub 2018 Nov 14.

Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, 100191, China.

Titanium dioxide nanoparticles (TiO NPs) have already been used as food additive in various products and are usually consumed with a considerable amount of sugar. Oral consumption of TiO NPs poses concerning health risks; however, research on the combined effect of ingested TiO NPs and glucose is limited. We examined young Sprague-Dawley rats administrated TiO NPs orally at doses of 0, 2, 10 and 50 mg/kg body weight per day with and without 1. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3750
Publisher Site
http://dx.doi.org/10.1002/jat.3750DOI Listing
November 2018
6 Reads

Developmental effects of neonatal fractionated co-exposure to low-dose gamma radiation and paraquat on behaviour in adult mice.

J Appl Toxicol 2018 Nov 13. Epub 2018 Nov 13.

Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden.

Radiological methods for screening, diagnostics and therapy are often used in healthcare; however, it has recently been reported that developmental exposure to low-dose ionizing radiation (IR) causes neurotoxicity. Environmental chemicals also have the potential to affect the developing brain and the concomitant effects caused by IR and chemicals are of high interest today. We therefore aim to investigate if low-dose IR can interact with the known neurotoxicant paraquat to induce neurotoxicity in the neonatal mouse model. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3748
Publisher Site
http://dx.doi.org/10.1002/jat.3748DOI Listing
November 2018
7 Reads

Food colorant Sunset Yellow (E110) intervenes developmental profile of zebrafish (Danio rerio).

J Appl Toxicol 2018 Nov 13. Epub 2018 Nov 13.

Department of Zoology, Karnatak University, Dharwad, 580 003, India.

In this study, we tested the teratogenic/embryotoxic potentials of food colorant, Sunset Yellow (E110) using zebrafish embryos as a model. Laboratory-raised developing embryos of Danio rerio were exposed to graded concentrations (00, 0.1, 1. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3747
Publisher Site
http://dx.doi.org/10.1002/jat.3747DOI Listing
November 2018
11 Reads

Vanadium compounds and cellular death mechanisms in the A549 cell line: The relevance of the compound valence.

J Appl Toxicol 2018 Nov 8. Epub 2018 Nov 8.

Departamento de Biología y Tisular, Facultad de Medicina, UNAM, Mexico.

Non-small lung cell carcinoma has a high morbidity and mortality rates. The elective treatment for stage III and IV is cisplatinum that conveys serious toxic side effects. Vanadium compounds are metal molecules with proven antitumor activity that depends on its valence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3746DOI Listing
November 2018
2 Reads

Chronic cadmium exposure induced hepatic cellular stress and inflammation in aged female mice.

J Appl Toxicol 2018 Oct 29. Epub 2018 Oct 29.

Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, China.

Previous studies have revealed that acute cadmium (Cd) exposure led to inflammation in different organs through an oxidative stress mechanism. However, whether chronic Cd exposure induces inflammation in liver and the mechanistic link between inflammation and cell stress remains unclear. In the present study, we investigated the effects of chronic Cd exposure on hepatic cellular stress and inflammatory responses. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3742
Publisher Site
http://dx.doi.org/10.1002/jat.3742DOI Listing
October 2018
4 Reads
2.982 Impact Factor

Searching for tryptase in the RBL-2H3 mast cell model: Preparation for comparative mast cell toxicology studies with zebrafish.

J Appl Toxicol 2018 Oct 30. Epub 2018 Oct 30.

Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, 04469, USA.

Mast cells comprise a physiologically and toxicologically important cell type that is ubiquitous among species and tissues. Mast cells undergo degranulation, in which characteristic intracellular granules fuse with the plasma membrane and release many bioactive substances, such as enzymes β-hexosaminidase and tryptase. Activity of mast cells in the toxicology model organism, zebrafish, has been monitored via tryptase release and cleavage of substrate N-α-benzoyl-dl-Arg-p-nitroanilide (BAPNA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3738DOI Listing
October 2018

Chemical induction of hepatic apoptosis in rodents.

J Appl Toxicol 2019 Feb 23;39(2):178-190. Epub 2018 Oct 23.

University of Petra Pharmaceutical Center (UPPC), Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan.

The urge of identifying new pharmacological interventions to prevent or attenuate liver injury is of critical importance and needs an expanded experimental toolbox. Hepatocyte injury and cellular death is a prominent feature behind the pathology of liver diseases. Several research activities focused on identifying chemicals and hepatotoxicants that induce cell death by apoptosis, in addition to presenting its corresponding signaling pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3740DOI Listing
February 2019
1 Read

Whole-animal accumulation, oxidative stress, transcriptomic and metabolomic responses in the pink shrimp (Pandalus montagui) exposed to teflubenzuron.

J Appl Toxicol 2018 Oct 21. Epub 2018 Oct 21.

Institute of Marine Research, Nordnes, 5817, Bergen, Norway.

The benzoylurea chitin synthesis inhibitor teflubenzuron, widely used against sea lice in North Atlantic aquaculture, may pose an environmental threat to non-targeted crustaceans. In this experiment, laboratory acclimated pink shrimp (Pandalus montagui), a species found in fjords with Atlantic salmon farming, were exposed to dietary teflubenzuron for 46 days (control; low dose: 0.01 μg/g; high dose: 0. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3739
Publisher Site
http://dx.doi.org/10.1002/jat.3739DOI Listing
October 2018
6 Reads

Comparison of the metabolism of 10 chemicals in human and pig skin explants.

J Appl Toxicol 2019 Feb 21;39(2):385-397. Epub 2018 Oct 21.

Pierre Fabre Dermo-Cosmétique, Toulouse, France.

Skin metabolism is important to consider when assessing local toxicity and/or penetration of chemicals and their metabolites. If human skin supply is limited, pig skin can be used as an alternative. To identify any species differences, we have investigated the metabolism of 10 chemicals in a pig and human skin explant model. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3730
Publisher Site
http://dx.doi.org/10.1002/jat.3730DOI Listing
February 2019
68 Reads

Strain and interindividual differences in lamotrigine-induced liver injury in mice.

J Appl Toxicol 2018 Oct 16. Epub 2018 Oct 16.

Department of Drug Safety Sciences, Division of Clinical Pharmacology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, 466-8550, Japan.

Lamotrigine (LTG) has been widely prescribed as an antipsychotic drug, although it causes idiosyncratic drug-induced liver injury in humans. LTG is mainly metabolized by UDP-glucuronosyltransferase, while LTG undergoes bioactivation by cytochrome P450 to a reactive metabolite; it is subsequently conjugated with glutathione, suggesting that reactive metabolite would be one of the causes for LTG-induced liver injury. However, there is little information regarding the mechanism of LTG-induced liver injury in both humans and rodents. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3736
Publisher Site
http://dx.doi.org/10.1002/jat.3736DOI Listing
October 2018
20 Reads

Metabonomics analysis of kidneys in rats administered with chronic low-dose cadmium by ultra-performance liquid chromatography-mass spectrometry.

J Appl Toxicol 2018 Oct 16. Epub 2018 Oct 16.

Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, Heilongjiang, China.

This study aimed to investigate the nephrotoxicity in rats administered with chronic low-dose cadmium (Cd) by ultra-performance liquid chromatography-mass spectrometry. A total of 40 male Sprague-Dawley rats were randomly assigned to four groups, namely: control; low-dose (0.13 mg/kg·body weight [bw]); middle-dose (0. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3735
Publisher Site
http://dx.doi.org/10.1002/jat.3735DOI Listing
October 2018
19 Reads

In chemico assessment of potential sensitizers: Stability and direct peptide reactivity of 24 fragrance ingredients.

J Appl Toxicol 2019 Feb 16;39(2):398-408. Epub 2018 Oct 16.

National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.

Twenty-four pure fragrance ingredients of concern as potential skin sensitizers were previously subjected to degradation studies and evaluated using the high throughput with dansyl cysteamine (HTS-DCYA) method. The experimental results showed that two-thirds of the 24 fragrance ingredients underwent chemical degradation. In some cases, such degradation was accompanied by an increase in thio-reactivity. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jat.3732
Publisher Site
http://dx.doi.org/10.1002/jat.3732DOI Listing
February 2019
4 Reads

Prediction of clinically relevant drug-induced liver injury from structure using machine learning.

J Appl Toxicol 2018 Oct 16. Epub 2018 Oct 16.

Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.

Drug-induced liver injury (DILI) is the most common cause of acute liver failure and often responsible for drug withdrawals from the market. Clinical manifestations vary, and toxicity may or may not appear dose-dependent. We present several machine-learning models (decision tree induction, k-nearest neighbor, support vector machines, artificial neural networks) for the prediction of clinically relevant DILI based solely on drug structure, with data taken from published DILI cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3741DOI Listing
October 2018
1 Read

Type of endothelial cells affects HepaRG cell acetaminophen metabolism in both 2D and 3D porous scaffold cultures.

J Appl Toxicol 2018 Oct 11. Epub 2018 Oct 11.

School of Chemical Engineering, Oklahoma State University, Stillwater, OK, 74078, USA.

Recent advances in developing in vitro tissue models show that function of hepatocytes is altered in when cultured in 3D configuration and co-culturing with various non-parenchymal cells. However, tissue source for such non-parenchymal cells on viability and metabolic products of hepatocytes have not been explored. In this study, we evaluated the effect of 2D and 3D cultures either with HepaRG cells alone or in combination with liver sinusoidal endothelial cells (LSECs) and human umbilical vein ECs (HUVECs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jat.3737DOI Listing
October 2018