6,638 results match your criteria Journal of Alzheimer's Disease[Journal]


Where Do Ultrafine Particles and Nano-Sized Particles Come From?

J Alzheimers Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Agricultural, Environmental and Food Sciences (DiAAA), University of Molise, Campobasso, Italy.

This paper presents an overview of the literature studies on the sources of ultrafine particles (UFPs), nanomaterials (NMs), and nanoparticles (NPs) occurring in indoor (occupational and residential) and outdoor environments. Information on the relevant emission factors, particle concentrations, size, and compositions is provided, and health relevance of UFPs and NPs is discussed. Particular attention is focused on the fraction of particles that upon inhalation deposit on the olfactory bulb, because these particles can possibly translocate to brain and their possible role in neurodegenerative diseases is an important issue emerging in the recent literature. Read More

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http://dx.doi.org/10.3233/JAD-181266DOI Listing

The Prevalence and Subtypes of Young Onset Dementia in Central Norway:\\ A Population-Based Study.

J Alzheimers Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Neuromedicine and Movement Science (INB), NTNU, Faculty of Medicine and Health Sciences, Trondheim, Norway.

Background: Young onset dementia poses several challenges for the individual, health care, and society that are not normally relevant for late onset dementia, but is little researched.

Objective: To determine the prevalence and subtypes of young onset dementia in a defined catchment area in central Norway.

Methods: The main sources of patient identification were the databases at the Department of Neurology, University Hospital of Trondheim (St. Read More

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http://dx.doi.org/10.3233/JAD-181223DOI Listing
April 2019
1 Read

Plasma Sphingolipids Mediate a Relationship Between Type 2 Diabetes and Memory Outcomes in Patients with Coronary Artery Disease Undertaking Exercise.

J Alzheimers Dis 2019 Apr 17. Epub 2019 Apr 17.

Cardiac Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, Toronto, Ontario, Canada.

Background: Exercise may combat cognitive decline and prevent recurrent cardiovascular events in coronary artery disease (CAD); however, evidence in type 2 diabetes (T2DM) has been mixed. T2DM and memory decline have been associated with differences in the plasma sphingolipidome.

Objective: Here, we will investigate whether T2DM-related sphingolipids predict less memory improvement over an exercise intervention for CAD. Read More

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http://dx.doi.org/10.3233/JAD-181203DOI Listing

Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin.

J Alzheimers Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Pharmacology & Therapeutics, Life Sciences Complex, McGill University, Montreal, Quebec, Canada.

There is increasing evidence suggesting that amyloidogenic proteins might form deposits in non-neuronal tissues in neurodegenerative disorders such as Alzheimer's or Parkinson's diseases. However, the detection of these aggregation-prone proteins within the human skin has been controversial. Using immunohistochemistry (IHC) and mass spectrometry tissue imaging (MALDI-MSI), fresh frozen human skin samples were analyzed for the expression and localization of neurodegenerative disease-related proteins. Read More

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http://dx.doi.org/10.3233/JAD-181191DOI Listing

Total Cerebral Small Vessel Disease Burden Is Related to Worse Performance on the Mini-Mental State Examination and Incident Dementia: A Prospective 5-Year Follow-Up.

J Alzheimers Dis 2019 Apr 15. Epub 2019 Apr 15.

State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.

Individual cerebral small vessel disease (CSVD) may cause cognitive decline. However, the association between total burden of CSVD and cognitive deterioration in the general population remains unclear. We aimed to determine whether total CSVD score is associated with cognitive performance change and incident dementia in the general population. Read More

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http://dx.doi.org/10.3233/JAD-181135DOI Listing

Recruitment of Older Veterans with Diabetes Risk for Alzheimer's Disease for a Randomized Clinical Trial of Computerized Cognitive Training.

J Alzheimers Dis 2019 Apr 15. Epub 2019 Apr 15.

James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.

Background: Type 2 diabetes mellitus (T2DM) is prevalent in the general United States population, and in the veteran population. T2DM has consistently been linked to increased risk for cognitive impairment, dementia, and Alzheimer's disease. Computerized cognitive training (CCT) is practical and inexpensive cognitive interventions that is an alternative to medication. Read More

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http://dx.doi.org/10.3233/JAD-180952DOI Listing

Tau Protein and Zebrafish Models for Tau-Induced Neurodegeneration.

J Alzheimers Dis 2019 Apr 15. Epub 2019 Apr 15.

Clinical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

Tauopathies are a specific type of slow and progressive neurodegeneration, which involves intracellular deposition of fibrillar material composed of abnormal hyperphosphorylation of the microtubule associated protein (MAP) tau. Despite many years of intensive research, our understanding of the molecular events that lead to neurodegeneration is far from complete. No effective therapeutic treatments have been defined, and questions surround the validity and utility of existing animal models. Read More

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http://dx.doi.org/10.3233/JAD-180917DOI Listing

Diagnostic Work-Up Is More Complete in Rural than in Urban Areas for Patients with Dementia: Results of a Swedish Dementia Registry Study.

J Alzheimers Dis 2019 Apr 12. Epub 2019 Apr 12.

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Background: Life in rural areas differs from life in urban areas not only in geographical conditions, but also in health care structure.

Objective: Our aim is to compare the diagnostic process and the management of dementia in rural and urban areas of Sweden.

Methods: We performed a cross-sectional study of patients with dementia living in rural (n = 16,428), intermediate (n = 18,033), and urban (n = 23,680) areas in Sweden including patients registered from 2007 through 2014 in the Swedish Dementia Registry (SveDem). Read More

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http://dx.doi.org/10.3233/JAD-190017DOI Listing
April 2019
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One Step Forward Toward a Surrogate Endpoint for Clinical Trials of Alzheimer's Disease Drugs: The Results of PharmaCog WP5 (European ADNI).

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

University of Lille, Inserm, CHU Lille, Lille, France.

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http://dx.doi.org/10.3233/JAD-190267DOI Listing
April 2019
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A Computerized Continuous-Recognition Task for Measurement of Episodic Memory.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

MemTrax, LLC, Redwood City, CA, USA.

Based on clinical observations of severe episodic memory (EM) impairment in dementia of Alzheimer's disease (AD), a brief, computerized EM test was developed for AD patient evaluation. A continuous recognition task (CRT) was chosen because of its extensive use in EM research. Initial experience with this computerized CRT (CCRT) showed patients were very engaged in the test, but AD patients had marked failure in recognizing repeated images. Read More

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http://dx.doi.org/10.3233/JAD-190167DOI Listing
April 2019
1 Read

Diabetes Promotes Development of Alzheimer's Disease Through Suppression of Autophagy.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Recent studies suggest that diabetes predisposes patients to develop neurodegenerative Alzheimer's disease (AD), although the underlying mechanisms have yet to be determined. Compromised autophagy of neuronal cells, which occurs in the early stages of AD, has been shown to enhance disease progression. However, autophagic regulation as a mechanism connecting diabetes and AD has not been shown before. Read More

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http://dx.doi.org/10.3233/JAD-190156DOI Listing
April 2019
3 Reads
4.151 Impact Factor

Effects of Transplanted Umbilical Cord Blood Mononuclear Cells Overexpressing GDNF on Spatial Memory and Hippocampal Synaptic Proteins in a Mouse Model of Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Kazan State Medical University, Kazan, Russia.

Background/objective: Alzheimer's disease (AD) is a progressive incurable neurodegenerative disorder. Glial cell line-derived neurotrophic factor (GDNF) is a prominent regulator of brain tissue and has an impressive potential for use in AD therapy. While its metabolism is still not fully understood, delivering neuropeptides such as GDNF via umbilical cord blood mononuclear cells (UCBMCs) to the sites of neurodegeneration is a promising approach in the development of innovative therapeutic avenues. Read More

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http://dx.doi.org/10.3233/JAD-190150DOI Listing
April 2019
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Associations between Depression, Depressive Symptoms, and Incidence of Dementia in Latin America: A 10/66 Dementia Research Group Study.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Health Service and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Background: A growing body of evidence suggests that depression is related to dementia in older adults. Previous research has been done in high-income countries and there is a lack of studies in low- and middle income countries (LMICs).

Objective: To examine the relationship between depressive symptoms and incidence of dementia in a population-based study of older adults in Latin America. Read More

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http://dx.doi.org/10.3233/JAD-190148DOI Listing
April 2019
1 Read
4.151 Impact Factor

SNARE Complex Polymorphisms Associate with Alterations of Visual Selective Attention in Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy.

The SNARE complex plays a crucial role in the synaptic exocytosis of neurotransmitters, a process involved in the Alzheimer's disease (AD), the most common form of dementia. SNAP-25, STX1a, and VAMP2 are the core proteins of the SNARE complex, and changes in protein level are suggested to contribute to cognitive impairment and neuropsychiatric disorders. Single nucleotide polymorphisms (SNPs) in SNARE complex genes were shown to be associated with different diseases and different cognitive impairments. Read More

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http://dx.doi.org/10.3233/JAD-190147DOI Listing
April 2019
4 Reads

Impact of Pre-Analytical Differences on Biomarkers in the ADNI and PPMI Studies: Implications in the Era of Classifying Disease Based on Biomarkers.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA.

Background: Neurodegenerative diseases require characterization based on underlying biology using biochemical biomarkers. Mixed pathology complicates discovery of biomarkers and characterization of cohorts, but inclusion of greater numbers of patients with different, related diseases with frequently co-occurring pathology could allow better accuracy. Combining cohorts collected from different studies would be a more efficient use of resources than recruiting subjects from each population of interest for each study. Read More

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http://dx.doi.org/10.3233/JAD-190069DOI Listing
April 2019
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VEGF-C Induces Alternative Activation of Microglia to Promote Recovery from Traumatic Brain Injury.

J Alzheimers Dis 2019 Apr 3. Epub 2019 Apr 3.

Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Traumatic brain injury (TBI), a brain disorder that causes death and long-term disability in humans, is increasing in prevalence, though there is a lack of protective or therapeutic strategies for mitigating the damage after TBI and for preserving neurological functionality. Microglia cells play a key role in neuroinflammation following TBI, but their regulation and polarization by a member of the vascular endothelial growth factor (VEGF) family, VEGF-C, is unknown. Here, we show that VEGF-C induced M2 polarization in a murine microglia cell line, BV-2, in vitro, by a mechanism that required signaling from its unique receptor, VEGF receptor 3 (VEGFR3). Read More

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http://dx.doi.org/10.3233/JAD-190063DOI Listing
April 2019
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Brain Amyloid-β Deposition and Blood Biomarkers in Patients with Clinically Diagnosed Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.

Brain amyloid-β (Aβ) deposition is a hallmark to define Alzheimer's disease (AD). We investigated the positive rate of brain Aβ deposition assessed with amyloid PET and blood Aβ levels in a cohort of probable AD patients who were diagnosed according to the 1984 NINCDS-ADRDA criteria. Eighty-four subjects with a clinical diagnosis of probable AD dementia, amnestic mild cognitive impairment (MCI), and cognitively normal (CN) status were subjected to 11C-Pittsburgh compound (PiB)-PET and 18F-fluorodeoxyglucose (FDG)-PET scans. Read More

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http://dx.doi.org/10.3233/JAD-190056DOI Listing
April 2019
4 Reads

Degeneration of the Suprachiasmatic Nucleus in an Alzheimer's Disease Mouse Model Monitored by in vivo Magnetic Resonance Relaxation Measurements and Immunohistochemistry.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Institute of Medical Physics and Biophysics, University of Leipzig, Leipzig, Germany.

In Alzheimer's disease (AD), disturbances in the circadian rhythm and sleep-wake cycle are frequently observed. Both are controlled by the master clock: the suprachiasmatic nucleus (SCN), which was reported in postmortem studies of AD subjects to be compromised. However, the influence of age and gender on the biophysical integrity and subtle microstructural changes of SCN and mechanistic connections between SCN dysfunction and AD progression in vivo remain to be explored. Read More

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http://dx.doi.org/10.3233/JAD-190037DOI Listing
April 2019
1 Read
4.151 Impact Factor

APOE ɛ4 and REM Sleep Behavior Disorder as Risk Factors for Sundown Syndrome in Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea.

Background: Sundown syndrome (SS) in patients with Alzheimer's disease (AD) is characterized by aggravation of behavioral problems at sunset. Disturbance of the circadian rhythm, a possible cause of SS, also facilitates amyloidopathy and reduces sleep quality. However, the associations of SS with amyloidopathy and sleep quality remain unclear. Read More

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http://dx.doi.org/10.3233/JAD-190032DOI Listing
April 2019
1 Read

Geographical Variation in the Diagnostic Rate and Quality of Dementia Diagnoses.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Early and accurate diagnosis of dementia opens the door to appropriate treatment, support, and counseling. Despite availability of evidence-based guidelines for diagnostic evaluation of dementia, the diagnostic rate in people with dementia is low and the quality of dementia diagnoses is unknown.

Objective: The overall aim of this register-based study was to analyze the quality of diagnostic evaluation of dementia by assessing nationwide geographical variations in a range of indicators. Read More

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http://dx.doi.org/10.3233/JAD-190030DOI Listing
April 2019
1 Read

Sirtuin 3 Mediates Tau Deacetylation.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Dignity Health Organization, Phoenix, AZ, USA.

Background: Emerging evidence shows tau acetylation has been observed in Alzheimer's disease (AD) brain at early Braak stages and is involved in regulating tau early accumulation. However, the effects of deacetylase Sirtuin 3 (Sirt3) on tau acetylation and its aggregations are unclear.

Objective: We studied the effects of Sirt3 on tau acetylation and its aggregations. Read More

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http://dx.doi.org/10.3233/JAD-190014DOI Listing
April 2019
2 Reads

Clinical Effects of Frontal Behavioral Impairment: Cortical Thickness and Cognitive Decline in Individuals with Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: Frontal behavioral impairment (FrBI) is commonly observed in various degenerative diseases and refers to various behavioral symptoms.

Objective: We investigated the effects of the presence of FrBI on cortical thickness, and the longitudinal neuropsychological changes in people in the predementia stage.

Methods: A total of 794 individuals completed neuropsychological tests and the Frontal Behavioral Inventory (FBI) Questionnaire, and underwent magnetic resonance (MR) scanning. Read More

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http://dx.doi.org/10.3233/JAD-190007DOI Listing
April 2019
2 Reads

Differences in Cataract Surgery Rates Based on Dementia Status.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.

Background: Cataract surgery substantially improves patient quality of life. Despite the rising prevalence of dementia in the US, little is known about use of cataract surgery among this group.

Objective: To evaluate the relationship between dementia status and cataract surgery. Read More

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http://dx.doi.org/10.3233/JAD-181292DOI Listing
April 2019
1 Read

A Novel PSEN1 M139L Mutation Found in a Chinese Pedigree with Early-Onset Alzheimer's Disease Increases Aβ42/Aβ40 ratio.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, P.R. Beijing, China.

Background: Presenilin1 (PSEN1) is the most common gene related to familial Alzheimer's disease (AD). Only several mutation types from Chinese have been reported, with less biological function research conducted.

Objectives: We explore the pathological function of PSEN1 M139L, a mutation located at α-helix of PSEN1 transmembrane 2, using predictive programs and in vitro study and compare its effects on Aβ production to those of an artificial PSEN1 S141G located at non α-helix. Read More

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http://dx.doi.org/10.3233/JAD-181291DOI Listing

A Synthetic Pro-Drug Peptide Reverses Amyloid-β-Induced Toxicity in the Rat Model of Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Neuroscience Research Unit, Department of Physiology, RPM College, Uttarpara, Hooghly, West Bengal, India.

Background: Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, involves the formation of the extracellular amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles. The current therapies against AD are symptomatic with limited benefits and associated major side effects. Inhibition of self-aggregation of Aβ peptides into higher order cross-β structure is one of the potential therapeutic approach which may counter oligomerization of Aβ peptide. Read More

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http://dx.doi.org/10.3233/JAD-181273DOI Listing

Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Laboratorio Cajal de Circuitos Corticales (CTB), Universidad Politécnica de Madrid, Madrid, Spain.

Despite extensive studies regarding tau phosphorylation progression in both human Alzheimer's disease cases and animal models, the molecular and structural changes responsible for neurofibrillary tangle development are still not well understood. Here, by using the antibodies AT100 (recognizes tau protein phosphorylated at Thr212 and Ser214 in the proline-rich region) and pS396 (recognizes tau protein phosphorylated at serine residue 396 in the C-terminal region), we examined phospho-tau immunostaining in neurons from the hippocampal CA1 region of 21 human cases with tau pathology ranging from Braak stage I to VI. Our results indicate that the AT100/pS396 ratio decreases in CA1 in accordance with the severity of the disease, along with its colocalization. Read More

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http://dx.doi.org/10.3233/JAD-181263DOI Listing

Timely Detection of Mild Cognitive Impairment in Italy: An Expert Opinion.

J Alzheimers Dis 2019 Apr 3. Epub 2019 Apr 3.

CNR, Neuroscience Institute, Aging Branch, Padua, Italy.

Mild cognitive impairment (MCI) generally evolves in a gradually progressive decline in memory and non-memory cognitive domains that may eventually decay to dementia. This process might be preventable by improving early detection of the MCI syndrome followed by proper and timely interventions. The aim of this work was providing helpful indications for a standardized early diagnosis of MCI, mainly focusing on the Italian elderly population. Read More

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http://dx.doi.org/10.3233/JAD-181253DOI Listing
April 2019
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Combined Biomarker Prognosis of Mild Cognitive Impairment: An 11-Year Follow-Up Study in the Alzheimer's Disease Neuroimaging Initiative.

J Alzheimers Dis 2019 Apr 3. Epub 2019 Apr 3.

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.

Background: Biomarkers may soon be used to predict decline in older individuals. Extended follow-up studies are needed to determine the stability of such biomarker-based predictions.

Objective: To examine the long-term performance of baseline cognitive, neuroimaging, and cerebrospinal fluid (CSF) biomarker-assisted prognosis in patients with mild cognitive impairment. Read More

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http://dx.doi.org/10.3233/JAD-181243DOI Listing
April 2019
2 Reads

A 2.5-Year Longitudinal Assessment of Naturalistic Driving in Preclinical Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 3. Epub 2019 Apr 3.

Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, MO, USA.

Background: Emerging evidence shows that cognitively normal older adults with preclinical Alzheimer's disease (AD) make more errors and are more likely to receive a marginal/fail rating on a standardized road test compared to older adults without preclinical AD, but the extent to which preclinical AD impacts everyday driving behavior is unknown.

Objective: To examine self-reported and naturalistic longitudinal driving behavior among persons with and without preclinical AD.

Method: We prospectively followed cognitively normal drivers (aged 65 + years) with (n = 10) and without preclinical AD (n = 10) for 2. Read More

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http://dx.doi.org/10.3233/JAD-181242DOI Listing
April 2019
1 Read

Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 3. Epub 2019 Apr 3.

Division of Geriatric Medicine, Saint Louis University School of Medicine, MO, USA.

Metformin is used for the treatment of insulin resistant diabetes. Diabetics are at an increased risk of developing dementia. Recent epidemiological studies suggest that metformin treatment prevents cognitive decline in diabetics. Read More

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http://dx.doi.org/10.3233/JAD-181240DOI Listing
April 2019
2 Reads

Integrated Mechanism of Lysine 351, PARK2, and STUB1 in AβPP Ubiquitination.

J Alzheimers Dis 2019 ;68(3):1125-1150

Molecular Neuroscience and Functional Genomics Laboratory, Delhi Technological University (Formerly DCE), Delhi, India.

Intracellular accumulation of aggregated amyloid-β, misfolded and non-functional proteinopathy, is the hallmark feature in Alzheimer's disease (AD). There are several mechanisms to clear the amyloid burden in a cell, including transcytosis across the blood-brain barrier, immune mediated, lysosomal pathway associated autophagy, enzymatic degradation by insulin degrading enzyme/neprilysin, and the proteasomal pathway. Among them, the ubiquitin proteasome system (UPS) is playing a critical role to prevent the intracellular amyloid-β deposition and to clear off the cellular burden in association with ubiquitin E3 ligase enzymes in AD. Read More

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http://dx.doi.org/10.3233/JAD-181219DOI Listing
January 2019
4.151 Impact Factor

Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model.

J Alzheimers Dis 2019 Apr 3. Epub 2019 Apr 3.

Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Kitaku, Okayama, Japan.

Alzheimer's disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation is related with AD pathology, we investigated the expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and alpha-2-HS-glycoprotein (AHSG), in a novel AD model (APP23) with HP at 12 month of age. As compared with wild type (WT, n = 10), immunohistochemical analysis showed a higher ITIH4 and a lower AHSG expressions in the cerebral cortex, hippocampus, and thalamus of the APP23 + HP group (n = 12) than the simple APP23 (n = 10) group ( *p <  0. Read More

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http://dx.doi.org/10.3233/JAD-181218DOI Listing
April 2019
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4.151 Impact Factor

Monocytes in the Peripheral Clearance of Amyloid-β and Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 3. Epub 2019 Apr 3.

Shaanxi Key Laboratory of Brain Disorders and School of Basic Medical Science, Xi'an Medical University, Xi'an, China.

Aging societies have high incidence rates of Alzheimer's disease (AD). AD is diagnosed at later disease stages and has a poor prognosis, and effective drugs and treatments for AD are lacking. The molecular mechanism of AD is not clear, and current research focuses primarily on amyloid-β (Aβ) deposition and tau protein hyperphosphorylation. Read More

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http://dx.doi.org/10.3233/JAD-181177DOI Listing

MARIO Project: Validation and Evidence of Service Robots for Older People with Dementia.

J Alzheimers Dis 2019 Apr 3. Epub 2019 Apr 3.

Department of Medical Sciences, Fondazione Casa Sollievo della Sofferenza, Geriatric Unit, San Giovanni Rotondo, Foggia, Italy.

Background: In the EU funded MARIO project, specific technological tools are adopted for the people living with dementia (PLWD). In the final stage of the project, a validation of the MARIO companion robot was performed from August to October 2017.

Objective: The aims of the present study are: 1) to illustrate the key results and evidence obtained in the final evaluation phase of the project across the three different pilot sites; 2) to assess the engagement dimensions of the PLWD who interacted with the MARIO robot; and 3) to assess the acceptability and efficacy of the MARIO companion robot on clinical, cognitive, neuropsychiatric, affective and social aspects, resilience, quality of life in PLWD, and burden level of the caregivers. Read More

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http://dx.doi.org/10.3233/JAD-181165DOI Listing
April 2019
1 Read

Genetic Sample Provision Among National Alzheimer's Coordinating Center Participants.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

University of Kentucky, Lexington, KY, USA.

Background: Genetic data help detect preclinical Alzheimer's disease and target individuals for clinical trials, making genetic research engagement critical for continued advancement in dementia prevention and treatment.

Objective: To understand what individual and institutional factors may relate to provision of genetic samples within the Alzheimer's Disease Centers.

Methods: Data from the National Alzheimer's Coordinating Center Uniform Data Set (2009-2016) were obtained along with genetic sample availability. Read More

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http://dx.doi.org/10.3233/JAD-181159DOI Listing

Gait Characteristics and Cognitive Decline: A Longitudinal Population-Based Study.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.

Background: Gait impairments are emerging predictors of dementia. However, few studies have examined whether gait predicts decline in specific cognitive domains.

Objective: This study aimed to determine whether gait speed or other gait characteristics were associated with decline in specific cognitive domains and the role of the ApoE4 genotype in modifying these associations. Read More

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http://dx.doi.org/10.3233/JAD-181157DOI Listing

Assessment of Conjunctive Binding in Aging: A Promising Approach for Alzheimer's Disease Detection.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Instituto de Psicología, Universidad del Valle, Cali, Colombia, USA.

The visual experience of objects lies in the ability to perceive and integrate their constitutive features. Conjunctive binding (CB) is the cognitive function that integrates the features of objects as wholes. This review covers the main findings (over the last 10 years) concerning the role of CB in visual working memory (VWM) and cognitive theory, its neural correlates, as well as perspectives for future work. Read More

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http://dx.doi.org/10.3233/JAD-181154DOI Listing
April 2019
2 Reads

Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.

Background: Trials of supplementation with omega-3 fatty acids (ω3-FAs) in patients with mild cognitive impairment or Alzheimer's disease (AD) have given inconsistent effects on cognitive decline. There is evidence of an interaction between B vitamin status and ω3-FAs in relation to brain atrophy and cognitive decline.

Objective: We investigated whether baseline levels of plasma total homocysteine (tHcy), a marker of B vitamin status, modify the effects of ω3-FAs supplementation on cognitive performance in moderate AD. Read More

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http://dx.doi.org/10.3233/JAD-181148DOI Listing
April 2019
1 Read
4.151 Impact Factor

U-Shaped Association Between Serum Uric Acid Levels and Cognitive Functions in Patients with Type 2 Diabetes: A Cross-Sectional Study.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, PR China.

Background: Serum uric acid (SUA) is a natural antioxidant that may exert neuroprotective effects against neurodegenerative diseases. The relationship between uric acid and cognitive functions has been extensively studied, but results remain conflicting.

Objective: To investigate potential associations between SUA level and mild cognitive impairment (MCI), and different domains of cognitive performances in patients with type 2 diabetes mellitus (T2DM). Read More

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http://dx.doi.org/10.3233/JAD-181126DOI Listing
April 2019
1 Read

Abnormal Brain Network Connectivity in a Triple-Network Model of Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, The Key Laboratory of Neuro-informatics and Rehabilitation Engineering of Ministry of Civil Affairs, and Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, P.R. China.

Resting-state fMRI studies have demonstrated that Alzheimer's disease (AD) is associated with aberrant organization and function of large-scale brain networks. However, the nature of the disruption of cross-network interactions in the key neurocognitive networks in the brain remains unclear. In this paper, we examined the 'triple-network model', including the default mode network (DMN), salience network (SN), and central executive network (CEN), to identify the cross-network interactions in late mild cognitive impairment (LMCI) and AD. Read More

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http://dx.doi.org/10.3233/JAD-181097DOI Listing
April 2019
1 Read

D-Cycloserine Improves Difficult Discriminations in a Pattern Separation Task in Alzheimer's Disease Patients with Dementia.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Bracket LLC, Boston, MA, USA.

Recent fMRI studies in human identified that pattern separation ability is associated with increased activity in the hippocampal dentate gyrus (DG), whereas no such DG changes are seen during pattern completion. Disruption to neurogenesis in the DG has been associated with Alzheimer's disease (AD). In a post-hoc analysis of two large unsuccessful AD clinical trials, we examined the effect of D-cycloserine (DCS) on a specific object pattern separation measure, a component of the picture recognition task from the Cognitive Drug Research (CDR) system. Read More

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http://dx.doi.org/10.3233/JAD-181094DOI Listing
April 2019
2 Reads

Early-Stage Identification and Pathological Development of Alzheimer's Disease Using Multimodal MRI.

J Alzheimers Dis 2019 ;68(3):1013-1027

Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.

Alzheimer's disease (AD) is one of the most common progressive and irreversible neurodegenerative diseases. The study of the pathological mechanism of AD and early-stage diagnosis is essential and important. Subjective cognitive decline (SCD), the first at-risk stage of AD occurring prior to amnestic mild cognitive impairment (aMCI), is of great research value and has gained our interest. Read More

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http://dx.doi.org/10.3233/JAD-181049DOI Listing
January 2019
1 Read

Biomarker Matrix to Track Short Term Disease Progression in Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Laboratory of Neuroimaging and Alzheimer's Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Background: Assessment of human brain atrophy in temporal regions using magnetic resonance imaging (MRI), resting state functional MRI connectivity in the left parietal cortex, and limbic electroencephalographic (rsEEG) rhythms as well as plasma amyloid peptide 42 (Aβ42) has shown that each is a promising biomarker of disease progression in amnestic mild cognitive impairment (aMCI) patients with prodromal Alzheimer's disease (AD). However, the value of their combined use is unknown.

Objective: To evaluate the association with cognitive decline and the effect on sample size calculation when using a biomarker composite matrix in prodromal AD clinical trials. Read More

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http://dx.doi.org/10.3233/JAD-181016DOI Listing
April 2019
5 Reads

Chronic Angiotensin 1-7 Infusion Prevents Angiotensin-II-Induced Cognitive Dysfunction and Skeletal Muscle Injury in a Mouse Model of Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Chuo-ku, Kumamoto, Japan.

 Alzheimer's disease (AD) is increasingly viewed as a neurological disease accompanied by a systemic disorder. Accumulating evidence supports that angiotensin II and angiotensin 1-7 exert opposite effects on various organs including the brain. However, the interaction between angiotensin II and angiotensin 1-7 in AD remains to be defined. Read More

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http://dx.doi.org/10.3233/JAD-181000DOI Listing
April 2019
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Prevalence of Sleep Disturbances in German Nursing Home Residents with Dementia: A Multicenter Cross-Sectional Study.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Institute of Social Medicine and Epidemiology, Nursing Research Unit, University of Lübeck, Lübeck, Germany.

Background: Sleep disturbances and insomnia occur frequently in people with dementia and are associated with a number of problems for affected persons, relatives, and carers.

Objective: Considering the lack of high-quality data especially from Germany, this study aimed to determine the prevalence of sleep disturbances and possible associated factors with in German nursing home residents.

Methods: Multicenter cross-sectional study. Read More

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http://dx.doi.org/10.3233/JAD-180784DOI Listing
April 2019
3 Reads

Extracellular Vesicle Biomarkers Track Cognitive Changes Following Intranasal Insulin in Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.

Background: Insulin resistance is implicated in Alzheimer's disease (AD), whereas intranasal insulin is an experimental treatment in clinical trials. We previously proposed insulin signaling mediators in plasma neuronal-enriched extracellular vesicles (EVs) as biomarkers of brain insulin resistance.

Objective: We sought to demonstrate the capacity of neuronal-enriched EV biomarkers to demonstrate target engagement in response to intranasal insulin and their ability to track treatment-associated cognitive changes in AD. Read More

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http://dx.doi.org/10.3233/JAD-180578DOI Listing
April 2019
3 Reads

Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer's Disease Are Associated with Oxidative Stress Regulation Mechanisms.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

School of Biomedical Sciences, Kent State University, Kent, OH, USA.

Administration of the recombinant analog of the pancreatic amyloid amylin, Pramlintide, has shown therapeutic benefits in aging and Alzheimer's disease (AD) models, both on cognition and amyloid-β (Aβ) pathology. However, the neuroprotective mechanisms underlying the benefits of Pramlintide remain unclear. Given the early and critical role of oxidative stress in AD pathogenesis and the known reactive oxygen species (ROS) modulating function of amyloids, we sought to determine whether Pramlintide's neuroprotective effects involve regulation of oxidative stress mechanisms. Read More

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http://dx.doi.org/10.3233/JAD-180421DOI Listing
April 2019
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Cardiorespiratory Fitness Modifies Influence of Sleep Problems on Cerebrospinal Fluid Biomarkers in an At-Risk Cohort.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

Background: Previous studies indicate that cardiorespiratory fitness (CRF) and sleep are each favorably associated with Alzheimer's disease (AD) pathophysiology, including reduced amyloid-β (Aβ) and tau pathology. However, few studies have examined CRF and sleep in the same analysis.

Objective: To examine the relationship between sleep and core AD cerebrospinal fluid (CSF) biomarkers among at-risk healthy late-middle-aged adults and determine whether CRF modifies this association. Read More

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http://dx.doi.org/10.3233/JAD-180291DOI Listing
April 2019
2 Reads

Greater Regional Cortical Thickness is Associated with Selective Vulnerability to Atrophy in Alzheimer's Disease, Independent of Amyloid Load and APOE Genotype.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Center for Advanced Technology and Education, Department of Electrical and Computer Engineering, Florida International University, Miami, FL, USA.

Background: Regional cortical thickness (rCTh) among cognitively normal (CN) adults (rCThCN) varies greatly between brain regions, as does the vulnerability to neurodegeneration.

Objective: The goal of this study was to: 1) rank order rCThCN for various brain regions, and 2) explore their vulnerability to neurodegeneration in Alzheimer's disease (AD) within these brain regions.

Methods: The relationship between rCTh among the CN group (rCThCN) and the percent difference in CTh (% CThDiff) in each region between the CN group and AD patients was examined. Read More

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http://dx.doi.org/10.3233/JAD-180231DOI Listing