49 results match your criteria Journal of Aging and Pharmacotherapy[Journal]

  • Page 1 of 1

Nonaspirin Nonsteroidal Antiinflammatory Drug Use in the Nordic Countries from a Cardiovascular Risk Perspective, 2000-2016: A Drug Utilization Study.

Pharmacotherapy 2019 Feb 8;39(2):150-160. Epub 2019 Feb 8.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Study Objective: Evidence on the cardiotoxicity of nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs), particularly diclofenac and the newer selective cyclooxygenase (COX)-2 inhibitors, has accumulated over the last decade. Our objective was to examine whether the use of NSAIDs in the Nordic countries changed with the emerging evidence, regulatory statements, and clinical guidelines advocating caution for the use of specific NSAIDs.

Design: Drug utilization study. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/phar.2217
Publisher Site
http://dx.doi.org/10.1002/phar.2217DOI Listing
February 2019
6 Reads

Association between Development of Dementia and Use of Benzodiazepines: A Systematic Review and Meta-Analysis.

Pharmacotherapy 2018 Oct 6;38(10):1010-1020. Epub 2018 Sep 6.

Drugs and Medicine, Universidade Julio de Mesquita Filho - Unesp, Araraquara, São Paulo, Brazil.

Study Objective: The use of benzodiazepines and the development of dementia is controversial, with studies indicating that benzodiazepines could be either a protective factor or a risk factor for dementia, or no association may exist between the two. Our objective was to identify whether such an association exists.

Design: Systematic review and meta-analysis of 12 prospective and retrospective cohort studies and case-control studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.2170DOI Listing
October 2018
5 Reads

Expanding Opportunities in the Postacute Long-Term Care Setting: Bringing Medication Safety to the Next Level.

Pharmacotherapy 2018 Aug 16;38(8):862-866. Epub 2018 Jul 16.

Rx Answers, LLC, Atlanta, Georgia.

Skilled nursing facilities and nursing homes are care settings that offer increasing opportunities for pharmacists to take the lead when addressing the new updated Centers for Medicare and Medicaid Services (CMS) requirements coupled with enhanced quality measures reporting. In addition, the complexity of the medication-related needs and comorbidities of the patients served in long-term care facilities promotes pharmacists practicing to the top of their license. Medication stewardship needs to be an interdisciplinary team activity led by the pharmacist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.2155DOI Listing
August 2018
17 Reads

Anticholinergics Influence Transition from Normal Cognition to Mild Cognitive Impairment in Older Adults in Primary Care.

Pharmacotherapy 2018 05 25;38(5):511-519. Epub 2018 Apr 25.

Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN.

Study Objective: To determine the influence of anticholinergic medications on transitions in cognitive diagnosis of older adults in primary care.

Design: This observational cohort study was conducted over a mean follow-up of 3.2 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.2106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036636PMC
May 2018
9 Reads

A Pharmacist-Led Program to Evaluate and Reduce Polypharmacy and Potentially Inappropriate Prescribing in Older HIV-Positive Patients.

Pharmacotherapy 2017 12 30;37(12):1498-1506. Epub 2017 Nov 30.

Division of Geriatrics and Hospital Medicine, Department of Medicine, San Francisco General Hospital, University of California at San Francisco, San Francisco, California.

Objective: The goal of this pharmacist-led study was to utilize two validated instruments, Beers Criteria and Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP), to assess potentially inappropriate prescribing (PIP) in older patients infected with the human immunodeficiency virus (HIV) and evaluate pharmacist interventions.

Design: Prospective randomized interventional trial.

Setting: Large urban clinic providing interdisciplinary primary and HIV care for ~2700 HIV-positive publicly insured patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.2043DOI Listing
December 2017
16 Reads

Association of Anticholinergic Burden with Cognitive Impairment and Health Care Utilization Among a Diverse Ambulatory Older Adult Population.

Pharmacotherapy 2016 11 5;36(11):1123-1131. Epub 2016 Nov 5.

Astellas Pharma Global Development, Northbrook, Illinois.

Study Objective: To determine the association between Anticholinergic Cognitive Burden (ACB) score and both cognitive impairment and health care utilization among a diverse ambulatory older adult population.

Design: Retrospective cohort study.

Data Source: Medication exposure and other clinical data were extracted from the Regenstrief Medical Record System (RMRS), and cognitive diagnosis was derived from a dementia screening and diagnosis study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.1843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362375PMC
November 2016
80 Reads

Development of the Tool to Reduce Inappropriate Medications (TRIM): A Clinical Decision Support System to Improve Medication Prescribing for Older Adults.

Pharmacotherapy 2016 06 28;36(6):694-701. Epub 2016 May 28.

Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, Connecticut.

Study Objective: To create a clinical decision support system (CDSS) for evaluating problems with medications among older outpatients based on a broad set of criteria.

Design: Web-based CDSS development.

Setting: Primary care clinics at a Veterans Affairs medical center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.1751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919149PMC
June 2016
10 Reads

Self-Reported Medication Adherence Barriers Among Ambulatory Older Adults with Mild Cognitive Impairment.

Pharmacotherapy 2016 Feb 1;36(2):196-202. Epub 2016 Feb 1.

Center for Observational and Real World Evidence, Merck Research Labs, Merck & Co. Inc., West Point, Pennsylvania.

Study Objective: To compare the frequencies of barriers to medication adherence reported by ambulatory older adults with a diagnosis of mild cognitive impairment (MCI) and ambulatory older adults with normal cognition.

Design: Cross-sectional study.

Setting: Outpatient clinics within a safety-net health care system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.1702DOI Listing
February 2016
13 Reads

Glomerular filtration rate equations overestimate creatinine clearance in older individuals enrolled in the Baltimore Longitudinal Study on Aging: impact on renal drug dosing.

Pharmacotherapy 2013 Sep 26;33(9):912-21. Epub 2013 Apr 26.

Department of Pharmacy Practice and Science, School of Pharmacy, University of Maryland, Baltimore, Maryland.

Objectives: To evaluate the performance of kidney function estimation equations and to determine the frequency of drug dose discordance in an older population.

Design: Cross-sectional analysis of data from community-dwelling volunteers randomly selected from the Baltimore Longitudinal Study of Aging from January 1, 2005, to December 31, 2010.

Subjects: A total of 269 men and women with a mean ± SD age of 81 ± 6 years, mean serum creatinine concentration (Scr ) of 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.1282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732548PMC
September 2013
19 Reads

Age-related macular degeneration.

Pharmacotherapy 2013 Aug 11;33(8):838-55. Epub 2013 Apr 11.

Department of Pharmacy Practice, Texas Southern University, College of Pharmacy and Health Sciences, Houston, Texas, USA.

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, and the prevalence of the disease increases exponentially with every decade after age 50 years. It is a multifactorial disease involving a complex interplay of genetic, environmental, metabolic, and functional factors. Besides smoking, hypertension, obesity, and certain dietary habits, a growing body of evidence indicates that inflammation and the immune system may play a key role in the development of the disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/phar.1264DOI Listing
August 2013
6 Reads

Effect of health literacy on drug adherence in patients with heart failure.

Pharmacotherapy 2012 Sep 28;32(9):819-26. Epub 2012 Jun 28.

Department of Pharmacy Practice, Center on Aging and the Life Course, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA.

Study Objective: To assess the effect of health literacy on drug adherence in the context of a pharmacist-based intervention for patients with heart failure.

Design: Post hoc analysis of a randomized controlled trial.

Setting: Inner-city ambulatory care practice affiliated with an academic medical center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/j.1875-9114.2012.01109.xDOI Listing
September 2012
18 Reads

Bone loss and fracture risk associated with thiazolidinedione therapy.

Pharmacotherapy 2010 Jul;30(7):716-27

School of Pharmacy, University of Mississippi, Jackson, Mississippi, USA.

The increasing use of thiazolidinediones for the treatment of type 2 diabetes mellitus, coupled with the potential for fractures in the aging population, poses a significant concern for health care providers. This concern is based on many reports of postapproval adverse musculoskeletal effects, particularly bone changes and fractures. To better understand the effects of thiazolidinediones on bone health, we conducted a PubMed search of articles published from January 1966-June 2009. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1592/phco.30.7.716DOI Listing
July 2010
4 Reads

Length of stay and hospital costs associated with a pharmacodynamic-based clinical pathway for empiric antibiotic choice for ventilator-associated pneumonia.

Pharmacotherapy 2010 May;30(5):453-62

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA.

Study Objective: To determine hospital costs associated with the use of a clinical pathway implemented in our intensive care units (ICUs) to optimize antibiotic regimen selection for patients with ventilator-associated pneumonia (VAP) compared with costs in a historical control group treated according to prescriber preference.

Design: Retrospective cost analysis from the hospital perspective.

Setting: Single, tertiary-care medical center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1592/phco.30.5.453DOI Listing
May 2010
26 Reads

Effect of self-efficacy and social support on adherence to antihypertensive drugs.

Pharmacotherapy 2010 May;30(5):432-41

Department of Pharmacy Practice and Science, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, USA.

Study Objective: To determine the relationship between poor adherence and self-efficacy or social support after a pharmacist intervention.

Design: Post-hoc analysis of data from two randomized controlled trials of physician-pharmacist collaborative interventions (6 and 9 mo, respectively) to improve blood pressure control.

Setting: Eleven university-affiliated primary care clinics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1592/phco.30.5.432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073236PMC
May 2010
32 Reads

Once-daily gentamicin dosing in pediatric patients without cystic fibrosis.

Pharmacotherapy 2010 Mar;30(3):248-53

Department of Pharmacy, Texas Children's Hospital, Houston, Texas 77030, USA.

Study Objective: To estimate an appropriate once-daily gentamicin dose and dosing interval for non-critical care pediatric patients older than 3 months of age without cystic fibrosis.

Design: Pharmacokinetic analysis of data from a retrospective medical record review.

Setting: Large academic children's hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1592/phco.30.3.248DOI Listing
March 2010
6 Reads

Once-daily gentamicin dosing in children with febrile neutropenia resulting from antineoplastic therapy.

Pharmacotherapy 2010 Jan;30(1):43-51

Department of Pharmacy, The Scarborough Hospital-General Division, Ontario, Canada.

Study Objectives: To evaluate an existing once-daily gentamicin dosing guideline in children with febrile neutropenia resulting from antineoplastic therapy and, if necessary, to develop a new simulated dosing guideline that would achieve pharmacokinetic targets more reliably after the first dose.

Design: Pharmacokinetic analysis of data from a retrospective medical record review.

Setting: Hematology-oncology unit of a university-affiliated pediatric hospital in Canada. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1592/phco.30.1.43DOI Listing
January 2010
25 Reads
2 Citations
2.660 Impact Factor

Disposition of two oral formulations of cyclosporine in pediatric patients receiving hematopoietic stem cell transplants.

Pharmacotherapy 2006 Jan;26(1):15-22

Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada.

Study Objectives: To compare the disposition of cyclosporine after the administration of two oral formulations to children undergoing hematopoietic stem cell transplantation, and to evaluate the relationship between whole blood cyclosporine concentrations during the dosing interval and the area under the whole blood concentration-time curve.

Design: Prospective, descriptive, crossover study.Setting. Read More

View Article

Download full-text PDF

Source
January 2006
5 Reads

Tumor necrosis factor-alpha and involuntary weight loss in elderly, community-dwelling adults.

Pharmacotherapy 2005 Mar;25(3):313-9

School of Pharmacy, the Center on Aging, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

Study Objective: To evaluate the association between involuntary weight loss and serum concentrations of tumor necrosis factor (TNF)-alpha in elderly, community-dwelling adults.

Design: Cross-sectional, single-time point investigation.

Setting: Two primary care ambulatory clinics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1592/phco.25.3.313.61607DOI Listing
March 2005
5 Reads

Anticoagulant prophylaxis in medical patients: an objective assessment.

Pharmacotherapy 2004 Aug;24(8 Pt 2):120S-126S

Ochsner Clinic Foundation, Section of Hospital-Based Internal Medicine, New Orleans, Louisiana 70121, USA.

Venous thromboembolism (VTE) is a clinically silent and potentially fatal disease that manifests as deep vein thrombosis (DVT) and pulmonary embolism. Venous thromboembolism remains a serious public health challenge, with an ever-increasing odds ratio of occurrence given the aging population in the United States. This article reviews the epidemiology of VTE; risk factor identification and stratification as a means of advancing awareness, prevention, and detection of VTE; and prophylaxis options and their outcomes, particularly administration of unfractionated heparin (UFH) 5000 U subcutaneously every 12 versus 8 hours in the at-risk medical patient population. Read More

View Article

Download full-text PDF

Source
August 2004
25 Reads

Effect of age on international normalized ratio at the time of major bleeding in patients treated with warfarin.

Pharmacotherapy 2004 May;24(5):600-5

School of Pharmacy, University of Washington, Seattle, Washington 98195, USA.

Study Objectives: Because the risk of major bleeding associated with warfarin increases with increasing international normalized ratio (INR) as well as with advanced age, we evaluated the association between age and INR in patients with major bleeding events related to anticoagulation with warfarin.

Design: Retrospective record review.

Setting: Two university-affiliated anticoagulation clinics. Read More

View Article

Download full-text PDF

Source
May 2004
11 Reads

Impact of hospitalization on blood pressure control in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA).

Pharmacotherapy 2003 Feb;23(2):240-7

Section of Gerontology and Geriatrics, Stricht Center on Aging, Wake Forest University-Baptist Medical Center, Winston Salem, North Carolina 27157, USA.

Study Objectives: To evaluate whether hospitalization affects blood pressure control in hypertensive patients, and to identify factors associated with attainment of adequate blood pressure control and with aggressive pharmacologic treatment.

Design: Retrospective study.

Setting: Eighty-one hospitals throughout Italy. Read More

View Article

Download full-text PDF

Source
February 2003
11 Reads

Population pharmacokinetic modeling of pyrazinamide in children and adults with tuberculosis.

Pharmacotherapy 2002 Jun;22(6):686-95

Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA.

Study Objective: To determine population pharmacokinetic parameters of pyrazinamide after multiple oral doses given to children and adults with tuberculosis.

Design: Prospective, multiple-dose population pharmacokinetic study.

Setting: Five hospitals in the United States. Read More

View Article

Download full-text PDF

Source
June 2002
10 Reads

Impact of age and gender on the pharmacokinetics of gemtuzumab ozogamicin.

Pharmacotherapy 2001 Oct;21(10):1175-80

Department of Clinical Pharmacokinetics, Wyeth-Ayerst Research, Philadelphia, Pennsylvania 19101, USA.

Study Objective: To determine the pharmacokinetic parameters of the components of gemtuzumab ozogamicin and to assess the possible influence of age and gender on the values.

Design: Phase II, multicenter, open-label, nonrandomized, parallel study

Setting: Hospitals and outpatient oncology clinics.

Patients: Fifty-eight patients with acute myeloid leukemia in first relapse participated. Read More

View Article

Download full-text PDF

Source
October 2001
4 Reads

Drug therapy and prevalence of erectile dysfunction in the Massachusetts Male Aging Study cohort.

Pharmacotherapy 2001 Jun;21(6):676-83

New England Research Institutes, Watertown, Massachusetts 02472, USA.

Study Objective: To examine the association of commonly used drugs with erectile dysfunction (ED) at two time points.

Design: Population-based, cross-sectional, survey analysis.

Participants: Randomly selected cohort of men in the Massachusetts Male Aging Study (MMAS) that included 1476 men for the baseline (1987-1989) and 922 for the follow-up (1995-1997) analyses. Read More

View Article

Download full-text PDF

Source
June 2001
4 Reads

Antithrombotic drugs for secondary stroke prophylaxis.

Authors:
L C Pettigrew

Pharmacotherapy 2001 Apr;21(4):452-63

Sanders-Brown Center on Aging, Department of Neurology, University of Kentucky College of Medicine, Lexington 40536-0230, USA.

Stroke is the third most common cause of adult mortality in the United States. Antithrombotic agents form the mainstay of stroke prevention. Aspirin produces a modest reduction in the risk of second stroke and is widely recommended for initial therapy. Read More

View Article

Download full-text PDF

Source
April 2001
5 Reads

Enzymatic shunting: resolving the acetaminophen-warfarin controversy.

Authors:
D E Lehmann

Pharmacotherapy 2000 Dec;20(12):1464-8

Division of General Internal Medicine and Clinical Pharmacology, State University of New York Upstate Medical University, Syracuse 13210, USA.

Observational studies in patients have shown a dose-dependent enhancement of the anticoagulant effect of warfarin by acetaminophen whereas pharmacodynamic studies in healthy human volunteers have shown no such effect. This controversy is further intensified because any interaction between acetaminophen and racemic warfarin can involve only the weaker R-warfarin enantiomer. Certain drugs exclusively competing for the metabolism of R-warfarin enhance the anticoagulant effect of racemic warfarin and others do not. Read More

View Article

Download full-text PDF

Source
December 2000
5 Reads

Steady-state pharmacokinetics of citalopram in young and elderly subjects.

Pharmacotherapy 2000 Dec;20(12):1441-7

Department of Pharmacokinetics, Forest Laboratories, Inc., New York, New York 10022, USA.

Study Objectives: To compare the steady-state pharmacokinetics of citalopram after multiple-dose administration in elderly and young subjects, and to correlate pharmacokinetic measurements with tolerability.

Design: Single-blind, multiple-dose, dose-escalating, randomized, placebo-controlled trial.

Setting: The Orlando Clinical Research Center, Orlando, Florida. Read More

View Article

Download full-text PDF

Source
December 2000
5 Reads

Current discoveries on the cognitive effects of antiepileptic drugs.

Authors:
K J Meador

Pharmacotherapy 2000 Aug;20(8 Pt 2):185S-190S

Department of Neurology, Medical College of Georgia, Augusta 30912-3280, USA.

The cognitive effects of antiepileptic drugs (AEDs) are of particular concern to clinicians because these drugs are the primary therapeutic modality for managing epilepsy. In general, the cognitive effects of most AEDs are modest and offset by their benefit in reducing seizures. Nonetheless, the cognitive effects of a particular AED may be clinically significant when treating specific patient populations, such as children and the elderly. Read More

View Article

Download full-text PDF

Source
August 2000
4 Reads

Special considerations in treating children with epilepsy.

Authors:
S L Moshé

Pharmacotherapy 2000 Aug;20(8 Pt 2):171S-177S

Department of Neurology, Albert Einstein College of Medicine, Einstein/Montefiore Epilepsy Management Center, Bronx, New York 10461, USA.

The incidence of seizures is high in infants and children. Many epileptic syndromes have their onset early in life. The increase in seizure susceptibility of the immature brain may be due to several factors, including an imbalance between excitatory and inhibitory processes, age-specific differences in ionic transport and clearance systems, high incidence of epileptogenic stimuli early in life, and the age-specific expression of pre- and perinatal brain anomalies. Read More

View Article

Download full-text PDF

Source
August 2000
6 Reads

Testosterone and andropause: the feasibility of testosterone replacement therapy in elderly men.

Pharmacotherapy 1999 Aug;19(8):951-6

Clinical and Administrative Pharmacy Division, College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA.

Andropause, a syndrome in aging men, consists of physical, sexual, and psychologic symptoms that include weakness, fatigue, reduced muscle and bone mass, impaired hematopoiesis, oligospermia, sexual dysfunction, depression, anxiety, irritability, insomnia, memory impairment, and reduced cognitive function. Free testosterone levels begin to decline at a rate of 1% per year after age 40 years. It is estimated that 20% of men aged 60-80 years have levels below the lower limit of normal. Read More

View Article

Download full-text PDF

Source
August 1999
4 Reads

Economic considerations in Alzheimer's disease.

Pharmacotherapy 1998 Mar-Apr;18(2 Pt 2):68-73; discussion 79-82

School of Pharmacy, University of Wisconsin at Madison, 53706-1515, USA.

Alzheimer's disease (AD) is the third most expensive disease in the United States, costing society approximately $100 billion each year. It is one of the most prevalent illnesses in the elderly population, and with the aging of society, will become even more significant. Costs associated with AD include direct medical costs such as nursing home care, direct nonmedical costs such as in-home day care, and indirect costs such as lost patient and caregiver productivity. Read More

View Article

Download full-text PDF

Source
May 1998
5 Reads

Preclinical pharmacology of metrifonate.

Authors:
M W Jann

Pharmacotherapy 1998 Mar-Apr;18(2 Pt 2):55-67; discussion 79-82

Department of Pharmacy Practice and Pharmaceutical Sciences, Mercer University, Atlanta, Georgia 30341, USA.

Alzheimer's disease is a chronic neurodegenerative disorder that is characterized by memory impairment, cognitive dysfunction, behavioral disturbances, and deficits in activities of daily living. A consistent observation in these patients is that cholinergic neurons are affected and deteriorate over time, leading to decreased levels of acetylcholine (ACh). Acetylcholinesterase (AChE) inhibitors, which attempt to prevent the breakdown of ACh, may be classified as short acting, intermediate acting, and long acting based on AChE regeneration time. Read More

View Article

Download full-text PDF

Source
May 1998
4 Reads

N-desmethylclozapine, an insensitive marker of clozapine-induced agranulocytosis and granulocytopenia.

Pharmacotherapy 1997 Nov-Dec;17(6):1300-4

College of Pharmacy, University of Iowa, Iowa City 52246, USA.

We reviewed the charts of 58 patients with treatment-refractory schizophrenia who were receiving clozapine, to determine if the drug's active metabolite, N-desmethylclozapine, is a biologic marker for impending clozapine-induced granulocytopenia and agranulocytosis. No significant correlation between granulocyte counts and patient demographic variables of clozapine and N-desmethylclozapine steady-state plasma concentrations, clozapine:N-desmethylclozapine ratio, age, gender, clozapine dosage, smoking status, and race were found. We believe N-desmethylclozapine is not a clinically useful marker for monitoring the effect of clozapine on granulocyte integrity. Read More

View Article

Download full-text PDF

Source
January 1998
4 Reads

Pharmacokinetics of azithromycin after single- and multiple-doses in children.

Pharmacotherapy 1997 Sep-Oct;17(5):874-80

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, University of Tennessee, Memphis 38015-2794, USA.

Study Objective: To characterize the disposition and tolerance of azithromycin after single and multiple oral doses of 12 mg/kg in children with and without cancer.

Design: Open-label, nonrandomized pharmacokinetic study.

Setting: Two pediatric hospitals. Read More

View Article

Download full-text PDF

Source
November 1997
5 Reads

The influence of multiple dosing and age on the pharmacokinetics and pharmacodynamics of glipizide in patients with type II diabetes mellitus.

Pharmacotherapy 1996 Sep-Oct;16(5):760-8

Department of Pharmacy Practice, Wayne State University, Detroit, Michigan 48201, USA.

Study Objectives: To determine the pharmacokinetics and pharmacodynamics of glipizide after a single dose and 12 weeks of dosing in patients with type II diabetes mellitus, and evaluate the influence of aging.

Design: Comparison of single and multiple doses of glipizide.

Setting: University-affiliated outpatient internal medicine clinic and diabetes care unit. Read More

View Article

Download full-text PDF

Source
March 1997
5 Reads

Is there a fountain of youth? A review of current life extension strategies.

Pharmacotherapy 1996 Mar-Apr;16(2):183-200

The Center for Long Term Care Research and Education, Chesapeake, Virginia 23321-5652, USA.

Life expectancy has dramatically increased in industrialized countries since the 1900s due to advances in disease prevention and treatment, and improvements in nutrition and infant mortality. Thus, as a society we are living longer and experiencing more of the changes and declines associated with aging. Although the factors that cause our bodies to age are unknown, various medical interventions have been proposed and explored to prevent the process. Read More

View Article

Download full-text PDF

Source
November 1996
4 Reads

The effect of age and everyday exercise on steady-state plasma digoxin concentrations.

Pharmacotherapy 1995 Jul-Aug;15(4):502-8

Department of Pharmacy and Pharmaceutics, Medical College of Virginia/Virginia Commonwealth University, USA.

Age-related physiologic changes may significantly alter the disposition and pharmacologic characteristics of many drugs. The elderly are the most frequent users of digoxin because of increased prevalence of atrial fibrillation and congestive heart failure. This study was conducted to confirm the decrease in digoxin concentrations during exercise, to determine if age is a factor in this decrease, and to explore the difference between chronologic age and physiologic age. Read More

View Article

Download full-text PDF

Source
December 1995
4 Reads

Pharmacokinetics of oral decongestants.

Pharmacotherapy 1993 Nov-Dec;13(6 Pt 2):116S-128S; discussion 143S-146S

School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa.

Only three drugs are commonly used as oral decongestants--phenylpropanolamine (PPA), pseudoephedrine (PDE), and phenylephrine (PE). They are all chiral drugs that exist as stereoisomers. It is possible that each enantiomer can reflect significant enantioselective differences with regard to both pharmacokinetic and pharmacodynamic effects. Read More

View Article

Download full-text PDF

Source
March 1994
47 Reads

Differences in serum concentrations of and responses to generic verapamil in the elderly.

Pharmacotherapy 1993 Jul-Aug;13(4):359-68

College of Pharmacy, University of Illinois, Chicago.

Study Objective: To determine if there are greater differences in bioavailability of generic verapamil at steady state in elderly patients than in healthy young subjects.

Design: Double-blind, randomized, three-way crossover study.

Setting: Clinical research center at a general teaching hospital. Read More

View Article

Download full-text PDF

Source
September 1993
4 Reads

Finasteride: the first 5 alpha-reductase inhibitor.

Pharmacotherapy 1993 Jul-Aug;13(4):309-25; discussion 325-9

Program on Aging, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.

Finasteride is a synthetic 4-azasteroid that is a specific competitive inhibitor of 5 alpha-reductase, an intracellular enzyme that converts testosterone to dihydrotestosterone (DHT). It has no binding affinity for androgen receptor sites and itself possesses no androgenic, antiandrogenic, or other steroid hormone-related properties. It is well absorbed after oral administration, with absolute bioavailability in humans of 63% (range 34-108%). Read More

View Article

Download full-text PDF

Source
September 1993
4 Reads

Hypertension in the elderly: conventional wisdom revisited.

Authors:
L M Lopez

Pharmacotherapy 1991 ;11(3):225-36

College of Pharmacy, University of Florida, Gainesville 32610.

Elevated systolic and/or diastolic blood pressure in the elderly is a problem the extent of which may be somewhat overstated. In those elderly with definite hypertension, pathophysiology may differ from that of younger counterparts. The contribution of elevated plasma renin activity to hypertension and to the choice of therapy also appears to be exaggerated. Read More

View Article

Download full-text PDF

Source
September 1991
6 Reads

Pharmacokinetics and pharmacodynamics of labetalol in elderly and young hypertensive patients following single and multiple doses.

Pharmacotherapy 1990 ;10(2):92-9

Division of Clinical Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

Several physiologic changes accompany the aging process and may alter the pharmacokinetics and pharmacodynamics of drugs given to elderly patients. The primary purpose of the present investigation was to compare the pharmacokinetics of labetalol in young and elderly hypertensive patients. Limited data regarding the pharmacodynamics of labetalol in each of these age groups were also evaluated. Read More

View Article

Download full-text PDF

Source
July 1990
5 Reads

Clinical pharmacology of fluconazole.

Authors:
M N Dudley

Pharmacotherapy 1990 ;10(6 ( Pt 3)):141S-145S

Antinfective Pharmacology Research Unit, University of Rhode Island College of Pharmacy, Providence.

View Article

Download full-text PDF

Source
April 1991
11 Reads

Follow-up study of tolmetin users.

Pharmacotherapy 1989 ;9(2):91-4

Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Waltham, Massachusetts 02154.

A follow-up study of 8370 outpatients who filled over 24,000 prescriptions for tolmetin revealed no hospital admissions for acute allergic, blood, skin, or central nervous system illness within 90 days of filling a prescription or refill for the drug. There were two cases of liver disease and two cases of nephrotic syndrome in which an etiologic relationship to tolmetin seemed unlikely but could not be entirely ruled out. In addition, 11 patients were hospitalized for peptic ulcer disease and its complications. Read More

View Article

Download full-text PDF

Source
June 1989
3 Reads

Systemic absorption of topical lidocaine in elderly and young adults undergoing bronchoscopy.

Pharmacotherapy 1989 ;9(2):74-81

Department of Pharmacy Practice, University of Florida, Gainesville.

This study compared the systemic absorption of topically administered lidocaine in elderly and young adult patients who were undergoing fiberoptic bronchoscopy. Fourteen elderly subjects aged 60-72 years (mean 67 years) and five young subjects age 31-48 years (mean 42 years) were compared with respect to dosage requirements to achieve satisfactory local anesthesia, rate and extent of lidocaine systemic absorption, plasma drug levels, elimination half-life, and drug side effects. Blood samples were drawn prior to, during, and for an average of 3 hours after the completion of bronchoscopy. Read More

View Article

Download full-text PDF

Source
June 1989
4 Reads

Potential therapeutic indications for growth hormone and growth hormone-releasing hormone in conditions other than growth retardation.

Pharmacotherapy 1986 Nov-Dec;6(6):311-8

Growth hormone (GH) previously was available in limited supply and only for the treatment of GH-deficient children. The recent production of GH by recombinant DNA technology has provided a potential surfeit of this hormone and raises the possibility of its use in other conditions. In addition, the isolation, characterization, and synthesis of GH-releasing hormone (GRH) provides an opportunity to use this peptide in conditions in which increased circulating levels of GH are desired. Read More

View Article

Download full-text PDF

Source
April 1987
4 Reads

Pharmacokinetics of ciprofloxacin in elderly subjects.

Pharmacotherapy 1986 Mar-Apr;6(2):87-91

The pharmacokinetics of single-dose oral ciprofloxacin 500 mg was ascertained in 12 elderly and 12 young subjects. Mean age of the elderly volunteers was 75.4 years and the mean measured creatinine clearance in this group was 40. Read More

View Article

Download full-text PDF

Source
July 1986
4 Reads

Initial therapy for mild hypertension.

Authors:
J Wikstrand

Pharmacotherapy 1986 Mar-Apr;6(2):64-72

The treatment of mild hypertension has been a subject of controversy because its benefits versus risks are not as well established as they are for moderate to severe hypertension. Results of several studies, however, now show that treatment reduces the frequency of stroke in those with milder blood pressure elevations. New guidelines published by the Joint National Committee recommend that treatment of mild hypertension begin with either a diuretic or a beta blocker. Read More

View Article

Download full-text PDF

Source
July 1986
4 Reads

Pharmacogeriatrics.

Pharmacotherapy 1985 Nov-Dec;5(6):314-26

The elderly comprise one of the fastest growing populations in the United States. By the year 2020, an estimated 45 million will be classified as elderly. Aging is a highly variable process as declines occur in physiologic functions. Read More

View Article

Download full-text PDF

Source
January 1986
4 Reads
  • Page 1 of 1