799 results match your criteria Journal of Addiction Medicine [Journal]


Adverse Events During Treatment Induction With Injectable Diacetylmorphine and Hydromorphone for Opioid Use Disorder.

J Addict Med 2019 Feb 7. Epub 2019 Feb 7.

Centre for Health Evaluation & Outcome Sciences, Providence Health Care, St. Paul's Hospital (EOJ, HP, DG, AHA, MTS); School of Population and Public Health, University of British Columbia, Vancouver, BC (EOJ, HP, AHA, MTS); Northern Ontario School of Medicine, Sudbury, ON (DCM); Canadian Addiction Treatment Centres, Markham, ON (DCM); Providence Health Care, Providence Crosstown Clinic, Vancouver, BC (SH, SM); Centre Hospitalier de l'Université de Montréal, Hôpital Saint-Luc, CHUM Montréal, Montréal, QC, Canada (SB).

Objectives: The present study aims to describe a 3-day induction protocol for injectable hydromorphone (HDM) and diacetylmorphine (DAM) used in 3 Canadian studies and examine rates of opioid-related overdose and somnolence during this induction phase.

Methods: The induction protocol and associated data on opioid-related overdose and somnolence are derived from 2 clinical trials and one cohort study conducted in Vancouver and Montreal (2005-2008; 2011-2014; 2014-2018). In this analysis, using the Medical Dictionary for Regulatory Activities coding system we report somnolence (ie, drowsiness, sleepiness, grogginess) and opioid overdose as adverse events. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000505DOI Listing
February 2019

Initiation and Rapid Titration of Methadone in an Acute Care Setting for the Treatment of Opioid Use Disorder: A Case Report.

J Addict Med 2019 Feb 5. Epub 2019 Feb 5.

British Columbia Centre on Substance Use, Vancouver, BC (PH, PB, KC, SN); Department of Medicine, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada (PH, PB, SN).

Background: Although methadone is an effective treatment for opioid use disorder, its initiation requires prescribing at a subtherapeutic dose with subsequent titration to a therapeutic dose over many weeks. Accordingly, the methadone induction period can be a challenging one for individuals and can be associated with an increased risk for ongoing illicit drug use and consequently overdose. Given its capacity for regular clinical assessments, acute care settings may offer a unique opportunity to reduce the duration of the induction period for methadone maintenance therapy. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000507DOI Listing
February 2019
1 Read

Evaluation of the Brief Alcohol Withdrawal Scale Protocol at an Academic Medical Center.

J Addict Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD (BKL, VTG, RMK, ASJ); Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (AAHA, TN); Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (ESC); Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD (PM, KP); Center for Chemical Dependence, Johns Hopkins Bayview Medical Center, Baltimore, MD (DAR); Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD (SY).

Objectives: The standard of care for treatment of alcohol withdrawal is symptom-triggered dosing of benzodiazepines using a withdrawal scale. Abbreviated scales are desired for clinician efficiency. The objective of this study was to evaluate the use of the 5-item Brief Alcohol Withdrawal Scale (BAWS) protocol. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000510DOI Listing
February 2019
4 Reads

Severity of Analgesic Dependence and Medication-overuse Headache.

J Addict Med 2019 Feb 1. Epub 2019 Feb 1.

Research Centre, Akershus University Hospital, Lørenskog (CL, ESK); Department of Neurology, Akershus University Hospital, Nordbyhagen (CL, ESK); Institute of Clinical Medicine, Campus Akershus University Hospital, University of Oslo, Nordbyhagen, Norway (CL, MBR); National Addiction Centre, King's College, London, UK (MG); Head and Neck Research Group, Research Centre, Akershus University Hospital, Lørenskog (MBR); Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway (JS, ESK).

Background And Aims: Medication-overuse headache (MOH) is a common chronic headache caused by overuse of headache analgesics. It has similarities with substance dependence disorders. The treatment of choice for MOH is withdrawal of the offending analgesics. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000504DOI Listing
February 2019
1 Read

Medication Adherence Monitoring Using Smartphone Video Dosing in an Open-label Pilot Study of Monthly Naltrexone Plus Once-daily Bupropion for Methamphetamine Use Disorder: Feasibility and Acceptability.

J Addict Med 2019 Feb 1. Epub 2019 Feb 1.

University of Texas Southwestern Medical Center, Dallas, TX (RW); New York University, New York, NY (MH, BP); UCLA Integrated Substance Abuse Programs, Los Angeles, CA (BP, LM, WL); Retired from: National Institute on Drug Abuse Center for the Clinical Trials Network, Rockville, MD (SP).

Objectives: This article describes how smartphones were used to monitor and encourage medication adherence in a pilot study evaluating the potential efficacy of a combination pharmacotherapy for methamphetamine use disorder. We examine the feasibility, utility, and acceptability of using smartphones to capture dosing videos from the perspectives of participants and staff.

Methods: The study was an 8-week, open-label evaluation of extended-release injectable naltrexone combined with once-daily oral extended-release bupropion (BRP, Welbutrin XL, 450 mg/day). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000509DOI Listing
February 2019
1 Read

Reply to Dr Howe.

Authors:
Sharon S Allen

J Addict Med 2019 Jan/Feb;13(1):81-82

University of Minnesota Twin Cities, Minneapolis, MN.

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http://dx.doi.org/10.1097/ADM.0000000000000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363481PMC
January 2020

Pilot Trial of a Combined Cognitive Processing Therapy and Smoking Cessation Treatment.

J Addict Med 2019 Jan 17. Epub 2019 Jan 17.

Durham Veterans Affairs Medical Center, Durham, NC (EAD, PAD, SMW, SDM, JCB); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC (EAD, PAR, SMW, SDM, JCP); Veterans Affairs Mid-Atlantic Region Mental Illness Research, Education, and Clinical Center, Durham, NC (EAD, PAD, SDM, JCB); Veterans Affairs Center of Innovation to Accelerate Discovery and Practice Transformation, Durham, NC (SMW).

Objective/background: Posttraumatic stress disorder (PTSD) and smoking are often comorbid. Combining PTSD and smoking cessation treatments could increase access to each treatment and could provide improved rates of smoking cessation through reductions in PTSD and depressive symptoms.

Participants: Participants were veterans with current PTSD who smoked cigarettes and were willing to initiate treatment for both problems. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000502DOI Listing
January 2019
4 Reads

Treatment for Opioid Addiction Must Be Offered in General Hospitals: But How?

Authors:
Richard Saitz

J Addict Med 2019 Jan 14. Epub 2019 Jan 14.

Boston University Schools of Public Health & Medicine/Boston Medical Center, Boston, MA.

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http://dx.doi.org/10.1097/ADM.0000000000000501DOI Listing
January 2019
3 Reads

Alcohol Drinking in Chinese Methadone-maintained Clients: A Self-medication for Depression and Anxiety?

J Addict Med 2019 Jan 4. Epub 2019 Jan 4.

Research Center for Psychological and Health Sciences, China University of Geosciences, Wuhan, Hubei Province, China (B-LZ); Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, Hubei Province, China (B-LZ, Y-MX); Peking University Clinical Research Institute, Peking University Health Science Center, Beijing, China (W-XX); Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China (JL); Yidu Cloud (Beijing) Technology Co., Ltd., Beijing, China (W-BY, JY).

Objectives: Unhealthy alcohol use is associated with negative health outcomes in clients attending methadone maintenance therapy (MMT) programs. However, debates exist regarding the methadone dose of drinkers, and little is known about the health outcomes of drinkers with other types of alcohol use. This study examined the drinking pattern and its association with methadone dose, and depressive and anxiety symptoms in Chinese clients undergoing MMT. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000500DOI Listing
January 2019
9 Reads

Hospital-Based Addiction Medicine Healthcare Providers: High Demand, Short Supply.

J Addict Med 2019 Jan 4. Epub 2019 Jan 4.

British Columbia Centre on Substance Use (VB, SN); Department of Medicine, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada (SN).

: Substance use disorders account for a significant burden of disease and place an enormous strain on the health care system in the United States and beyond. Despite death tolls climbing, a myriad of evidence-based medications exist to effectively treat many substance use disorders including nicotine, alcohol, and opioid use disorders. To date, hospitals have largely been overlooked as a setting ripe for the delivery of specialized addiction care. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000488DOI Listing
January 2019
4 Reads

Recovery Goals and Long-term Treatment Preference in Persons Who Engage in Nonmedical Opioid Use.

J Addict Med 2019 Jan 4. Epub 2019 Jan 4.

Behavioral Pharmacology Research Unit, Johns Hopkins School of Medicine, Baltimore, MD (KRH, ASH, DAT, KED); Department of Psychiatry, UCSF School of Medicine, San Francisco, CA (DAT).

Background: While most opioid use disorder (OUD) treatment providers consider opioid abstinence to be the preferred outcome, little is known about the treatment preferences of the larger population of individuals who engage in nonmedical opioid use and have not yet sought treatment. This study sought to descriptively quantify the proportion of out-of-treatment individuals with nonmedical opioid use that have abstinent and nonabstinent recovery goals.

Methods: Participants (N = 235) who engage in nonmedical opioid use and met self-reported criteria for OUD were recruited online and participated in a cross-sectional survey on recovery goals and treatment perceptions. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000498DOI Listing
January 2019
1 Read

Predictors for 30-Day and 90-Day Hospital Readmission Among Patients With Opioid Use Disorder.

J Addict Med 2019 Jan 8. Epub 2019 Jan 8.

Department of Quality Management and Patient Safety, Beaumont Health, Southfield, MI (JLM); Substance Use Disorders Initiative, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA (SEW); School of Pharmacy, Northeastern University, Boston, MA (MSD); Department of Pharmacy, Massachusetts General Hospital, Boston, MA (RJR); Department of Health Sciences, Northeastern University, Boston, MA (JSJ); School of Pharmacy, Northeastern University, Boston, MA (JWD).

Objectives: To identify the incidence, characteristics, and predictors for 30 and 90-day readmission among acutely hospitalized patients with opioid use disorder (OUD).

Methods: This retrospective, cohort study evaluated consecutive adults with OUD admitted to an academic medical center over a 5-year period (10/1/11 to 9/30/16). Multivariable logistic regression was used to determine independent predictors for 30 and 90-day readmissions based on pertinent admission, hospital, and discharge variables collected via chart review and found to be different (with a P < 0. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000499DOI Listing
January 2019
5 Reads

Role of the Hospital in the 21st Century Opioid Overdose Epidemic: The Addiction Medicine Consult Service.

J Addict Med 2018 Dec 28. Epub 2018 Dec 28.

Oregon Health & Science University (OHSU) and Portland State University School of Public Health (KCP, DM), School of Medicine, MD/PhD Program, OHSU (KCP), Department of Psychiatry, School of Medicine, OHSU, Portland, OR (DM).

Objective: The aim of the study was to explore and describe the structure and design elements of addiction medicine consult (AMC) services within selected US hospitals.

Methods: As part of a larger mixed methods study, 10 qualitative semi-structured telephone interviews were completed with board-certified addiction medicine physicians affiliated with the Addiction Medicine Foundation's Addiction Medicine Fellowship Programs at 9 US hospitals. Interviews were transcribed, coded, and analyzed using a directed content analysis. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000496DOI Listing
December 2018
1 Read

Tools to Support Hospital-Based Addiction Care: Core Components, Values, and Activities of the Improving Addiction Care Team.

J Addict Med 2018 Dec 28. Epub 2018 Dec 28.

Oregon Health & Science University, Portland, OR.

: Hospitals are increasingly filled with people admitted for medical and surgical complications of substance use disorder (SUD). Hospitalization can be a reachable moment to engage and initiate SUD care. Yet most hospitals do not have systems in place to adequately address addiction, and most providers have little to no addiction training. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000487DOI Listing
December 2018
12 Reads

Prevalence, Incidence, and Factors Associated With Substance Use Among Medical Students: A 2-Year Longitudinal Study.

J Addict Med 2018 Dec 27. Epub 2018 Dec 27.

School of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

Objectives: Although there are a number of studies about substance use by medical students, the majority are still cross-sectional. We aimed to investigate prevalence, 2-year incidence, and factors associated with substance use during medical training.

Methods: This longitudinal study included medical students in 4 different waves (with each wave equaling 1 semester). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000497DOI Listing
December 2018
1 Read

Toward Gender-inclusive, Nonjudgmental Alcohol Interventions for Pregnant People: Challenging Assumptions in Research and Treatment.

J Addict Med 2018 Dec 27. Epub 2018 Dec 27.

Institute for Gender, Race, Sexuality and Social Justice, University of British Columbia, British Columbia, Canada (AJL); School of Population and Public Health, University of British Columbia, British Columbia, Canada (AJL); British Columbia Centre on Substance Use, Vancouver, Canada (RK); Department of Medicine, University of British Columbia, Vancouver, Canada (RK).

: Epidemiological and clinical evidence clearly indicates that binge and/or heavy alcohol use while pregnant can be dangerous for the fetus. As such, there is a large body of research evaluating interventions to address harms associated with alcohol use during pregnancy. Unfortunately, based on our assessment of the scientific literature in this area, including a reading of three high-impact systematic reviews, there are several key areas where the language being used is hindering efforts to address alcohol harms during pregnancy in nonjudgmental and gender-inclusive ways. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000495DOI Listing
December 2018
1 Read

Technology Use Patterns Among Patients Enrolled in Inpatient Detoxification Treatment.

J Addict Med 2018 Dec 20. Epub 2018 Dec 20.

NYU College of Nursing (NL); NYU Department of Population Health (JDL, BT, PG); Johns Hopkins School of Public Health (AH); National Development and Research Institutes, Inc, New York, NY (MCA).

Background: Technology-based interventions offer a practical, low-cost, and scalable approach to optimize the treatment of substance use disorders (SUDs) and related comorbidities (HIV, hepatitis C infection). This study assessed technology use patterns (mobile phones, desktop computers, internet, social media) among adults enrolled in inpatient detoxification treatment.

Methods: A 49-item, quantitative and qualitative semi-structured survey assessed for demographic characteristics, technology use patterns (ie, mobile phone, text messaging [TM], smart phone applications, desktop computer, internet, and social media use), privacy concerns, and barriers to technology use. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000494DOI Listing
December 2018
1 Read

Naloxone Availability and Pharmacy Staff Knowledge of Standing Order for Naloxone in Pennsylvania Pharmacies.

J Addict Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Emergency Medicine, Perelman School of Medicine (RLG, JP, FS, RMM, ZFM); Leonard Davis Institute of Health Economics (EA, ZFM); Penn Medicine Center for Digital Health, University of Pennsylvania, Philadelphia, PA (RMM).

Objective: To assess the availability and price of naloxone as well as pharmacy staff knowledge of the standing order for naloxone in Pennsylvania pharmacies.

Methods: We conducted a telephone audit study from December 2016 to April 2017 in which staff from Pennsylvania pharmacies were surveyed to evaluate naloxone availability, staff understanding of the naloxone standing order, and out-of-pocket cost of naloxone.

Results: Responses were obtained from 682 of 758 contacted pharmacies (90% response rate). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000492DOI Listing
December 2018
1 Read

"I didn't want to be on Suboxone at first…"- Ambivalence in Perinatal Substance Use Treatment.

J Addict Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Research, UNC Health Sciences at MAHEC; University of North Carolina-Asheville; Department of Family Medicine, Boston University School of Medicine (BO); UNC Health Sciences at MAHEC (CL).

Objectives: The objectives of this article are to present findings from recent qualitative research with patients in a combined perinatal substance use treatment program in Central Appalachia, and to describe and analyze participants' ambivalence about medication-assisted treatment for opioid use disorder (OUD), in the context of widespread societal stigma and judgement.

Methods: We conducted research in a comprehensive outpatient perinatal substance use treatment program housed in a larger obstetric practice serving a large rural, Central Appalachian region. The program serves patients across the spectrum of substance use disorders but specifically offers medication-assisted treatment to perinatal patients with OUD. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000491DOI Listing
December 2018
1 Read

Opioid and Cannabis Co-Use among Adults with Chronic Pain: Relations to Substance Misuse, Mental Health, and Pain Experience.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, University of Houston, Houston, TX (AHR, JB, DJP, MJV); Department of Psychology, Louisiana State University, Baton Rouge, LA (JDB); College of Nursing, Washington State University, Washington, DC (MFO); Department of Psychology, Syracuse University, New York, NY (JWD); Department of Behavioral Science, The University of Texas MD Anderson Cancer Center (MJZ); and HEALTH Institute, University of Houston, Houston, TX (MJZ).

Objectives: Opioid misuse constitutes a significant public health problem and is associated with a host of negative outcomes. Despite efforts to curb this increasing epidemic, opioids remain the most widely prescribed class of medications. Prescription opioids are often used to treat chronic pain despite the risks associated with use, and chronic pain remains an important factor in understanding this epidemic. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000493DOI Listing
December 2018
7 Reads

Use of Buprenorphine-Naloxone in the Treatment of Tianeptine Use Disorder.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Spectrum Health, Center for Integrative Medicine, Grand Rapids, MI (PT); Boston University Department of Medicine, Section of General Internal Medicine, Clinical Addiction Research and Education Unit, School of Medicine & Boston Medical Center, Boston, MA (AYW).

: Tianeptine is an atypical antidepressant which exerts an opioid-like effect on the μ-opioid receptor. There is well documented intentional misuse and addiction to tianeptine in Europe, and this is increasingly being seen in the United States. We presented a case of buprenorphine/naloxone successfully being used to aid in cessation and subsequent abstinence from tianeptine after years of use. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000490DOI Listing
December 2018
1 Read

Obstetric and Pediatric Provider Perspectives on Mandatory Reporting of Prenatal Substance Use.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health (MJ); University of Pittsburgh School of Medicine (SM, CH); Magee-Womens Research Institute, University of Pittsburgh (JCC); Departments of Obstetrics, Gynecology and Reproductive Sciences and Internal Medicine, University of Pittsburgh, Pittsburgh, PA (JCC).

Objective: In many states, health care providers are legally required to report pregnant women who use substances, or infants affected by prenatal substance use, to child welfare authorities. The objective of this study was to characterize obstetric and pediatric providers' perceptions of and experiences with policies requiring mandatory reporting of prenatal substance use to child welfare authorities.

Methods: We conducted a qualitative interview study among 20 obstetric and pediatric providers to elicit participants' perspectives about and experience with current policy requiring mandatory reporting of prenatal substance use. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000489DOI Listing
December 2018
5 Reads

Impact of Fentanyl Use on Buprenorphine Treatment Retention and Opioid Abstinence.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Division of General Internal Medicine, Massachusetts General Hospital (SEW, YC, SR, LY, JM, NR); Harvard Medical School (SEW, YC, SR, JF, JM, NR); Department of Pathology, Massachusetts General Hospital, Boston, MA (JF).

Objectives: There has been a rapid increase in the presence of illicitly manufactured fentanyl in the heroin drug supply. Buprenorphine is an effective treatment for heroin and prescription opioid use disorder; however, little is known about treatment outcomes among people using fentanyl. We compared 6-month treatment retention and opioid abstinence among people initiating buprenorphine treatment who had toxicology positive for heroin compared to fentanyl at baseline. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000486DOI Listing
December 2018
1 Read

Evaluating the Impact of Prescribed Versus Nonprescribed Benzodiazepine Use in Methadone Maintenance Therapy: Results from a Population-based Retrospective Cohort Study.

J Addict Med 2018 Dec 12. Epub 2018 Dec 12.

Institute for Clinical and Evaluative Sciences, Toronto, Ontario, Canada (JKE, ASW, PK); Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PK); Northern Ontario School of Medicine, Sudbury, Ontario, Canada (JKE, AMF, DCM).

Objectives: Benzodiazepine (BZD) use is common in patients who are engaged in methadone as a treatment for opioid use disorder. BZD prescribing is generally discouraged for this patient population due to the increased risk of BZD dependence and BZD use disorder, medication-assisted treatment (MAT) discontinuation, and opioid-overdose death. However, some patients have concurrent mental health disorders, where BZD use may be clinically indicated. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000476DOI Listing
December 2018
9 Reads

Buprenorphine Pharmacology Review: Update on Transmucosal and Long-acting Formulations.

J Addict Med 2018 Oct 23. Epub 2018 Oct 23.

Department of Pharmacology, College of Medicine, University of Kentucky, Lexington, KY (MAC, SLW); Department of Behavioral Science, University of Kentucky, Lexington, KY (MRL, SLW); and Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY (MAC, MRL, SLW).

: Buprenorphine is an effective treatment for opioid use disorder. As a high-affinity, partial agonist for the mu-opioid receptor, buprenorphine suppresses opioid withdrawal and craving, reduces illicit opioid use, and blocks exogenous opioid effects including respiratory depression. Other pharmacologic benefits of buprenorphine are its superior safety profile compared with full opioid agonists and its long half-life that allows daily or less-than-daily dosing. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000457DOI Listing
October 2018
4 Reads

Idiopathic Thrombocytopenic Purpura Induced by Synthetic Cannabinoid.

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Internal Medicine (CC, KR, YG, ZF, MM); Department of Hematology (AP-P); Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL (SJC).

: Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder defined as low platelet count with normal bone marrow in the absence of other causes of thrombocytopenia. It is caused by autoantibodies binding to several platelet surface antigens which lead to premature destruction of the platelet by the reticuloendothelial system. ITP can be primary or secondary, and it is known to be associated with various infections and drugs. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000485DOI Listing
November 2018
3 Reads

Safety and Efficacy of Lofexidine for Medically Managed Opioid Withdrawal: A Randomized Controlled Clinical Trial.

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry, Johns Hopkins School of Medicine and Maryland Treatment Centers, Baltimore, MD (MF); CARMA Health, PLLC, Austin, TX (CT); Northwestern Medicine Central DuPage Hospital, Winfield, IL (DA); Pharmaceutical Development and Regulatory Affairs, US WorldMeds, LLC, Louisville, KY (KG); Biometrics, US WorldMeds, LLC, Louisville, KY (TC); Consultant to US WorldMeds, LLC, Louisville, KY (CWG).

Objectives: To investigate the safety and efficacy of lofexidine for treating opioid withdrawal syndrome (OWS) and facilitating completion of opioid withdrawal.

Methods: A multicenter, double-blind, placebo-controlled study was conducted at 18 US centers from June 2013 to December 2014. Participants (n = 603) aged ≥18 years, dependent on short-acting opioids, and seeking withdrawal treatment, randomized 3:3:2 to receive lofexidine 2. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000474DOI Listing
November 2018
2 Reads

Lofexidine for Opioid Withdrawal: Small Effects at an Exorbitant Price.

Authors:
David N Juurlink

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Divisions of General Internal Medicine and Clinical Pharmacology & Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/ADM.0000000000000473DOI Listing
November 2018
4 Reads

Comparison of Perioperative Systemic Lidocaine or Systemic Ketamine in Acute Pain Management of Patients With Opioid Use Disorder After Orthopedic Surgery.

J Addict Med 2018 Nov 28. Epub 2018 Nov 28.

Shiraz Anesthesiology and Intensive Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction And Aims: Patients with opioid use disorder experience great challenges during acute pain management due to opioid tolerance or withdrawal symptoms. Previous studies have recommended the use of adjuvant drugs in these patients. In this study, we compared the effect of intraoperative lidocaine with ketamine in postoperative pain management of these patients. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000483DOI Listing
November 2018
3 Reads

Impact of In-utero Exposure to Selective Serotonin Reuptake Inhibitors and Opioids on Neonatal Opioid Withdrawal Syndrome.

J Addict Med 2018 Nov 21. Epub 2018 Nov 21.

Department of Clinical Pharmacy, College of Pharmacy (VB-M); Department of Pediatrics, Michigan Medicine, University of Michigan (VB-M, JS, RES); Department of Pharmacy, Ascension St. John Hospital, Ann Arbor, MI (JR).

Objective: The objective of this study was to compare short-term outcomes of neonatal opioid withdrawal syndrome (NOWS) treatment in infants exposed in-utero to opioids and selective serotonin reuptake inhibitors (SSRIs) or opioids alone.

Methods: This was a retrospective cohort study of mother-infant dyads, 34 weeks or greater gestation, receiving opioids and/or SSRIs during pregnancy. Intravenous or oral methadone was administered according to a pre-existing protocol for NOWS treatment guided by withdrawal scores. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000484DOI Listing
November 2018
1 Read

Changes in Healthcare Encounter Rates Possibly Related to Cannabis or Alcohol following Legalization of Recreational Marijuana in a Safety-Net Hospital: An Interrupted Time Series Analysis.

J Addict Med 2018 Nov 20. Epub 2018 Nov 20.

Department of Medicine, Division of Hospital Medicine, Denver Health Medical Center, Denver (SLC, AK, MLH); Department of Medicine, Division of General Internal Medicine (SLC); Department of Family Medicine (SLC); Department of Psychiatry (CJH); Department of Medicine, Division of Hospital Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO (AK).

Objectives: Liberalization of marijuana laws in Colorado contributed to increases in cannabis-related adverse events over time. We examined characteristics of patients with healthcare encounters possibly related to cannabis and assessed the temporal association between legalization of recreational marijuana and healthcare encounters possibly attributed to cannabis.

Methods: Annual encounter rates possibly related to cannabis and alcohol were compared using negative binomial regression. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000480DOI Listing
November 2018
23 Reads

Receipt of Substance Use Disorder Treatment Among Patients Visiting Psychiatrists.

J Addict Med 2018 Nov 16. Epub 2018 Nov 16.

RTI International Rockville, MD Weill Cornell Medicine, New York, NY RTI International, Research Triangle Park, NC.

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http://dx.doi.org/10.1097/ADM.0000000000000478DOI Listing
November 2018
13 Reads

Impact of Nicotine and Other Stimulants on Sleep in Young Adults.

J Addict Med 2018 Nov 16. Epub 2018 Nov 16.

Behavioral Medicine and Addiction Research Unit, Butler Hospital, Providence, RI (CMC, BJA, MDS); Health Law, Policy & Management, Boston University School of Public Health, Boston, MA (MDS).

Objectives: Sleep problems can have long-term negative consequences. This study explored the relationship of commonly used stimulant substances to poor sleep quality in young adults.

Methods: We surveyed 498 participants, aged 18 to 25, who reported recent alcohol or marijuana use. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000481DOI Listing
November 2018
10 Reads

Drug Use-Related Normative Misperceptions and Behaviors Among Persons Seeking Heroin Withdrawal Management.

J Addict Med 2018 Nov 16. Epub 2018 Nov 16.

Behavioral Medicine Department, Butler Hospital (SRK, BJA, MDS); Warren Alpert Medical School of Brown University, Providence, RI (SRK, GLB); Stanley Street Treatment and Resources, Inc., Fall River (GLB); Boston University School of Public Health, Boston, MA (MDS).

Objective: Normative perceptions about substance use are well-established predictors of substance use risk behaviors, yet no research to date has examined how people who use heroin perceive the drug use behaviors and their association with personal behaviors. In a sample of persons seeking heroin withdrawal, we compared normative beliefs (descriptive norms) about others' drug use behaviors, and examined the association between normative beliefs and behaviors.

Method: Participants (n = 241) were patients undergoing short-term inpatient heroin withdrawal management in Massachusetts. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000482DOI Listing
November 2018
7 Reads

Trends and Related Factors of Cannabis-Associated Emergency Department Visits in the United States: 2006-2014.

J Addict Med 2018 Nov 9. Epub 2018 Nov 9.

Department of Health Care Administration and Policy, School of Community Health Sciences, University of Nevada, Las Vegas, NV (JJS); Department of Environmental and Occupational Health, School of Community Health Sciences, University of Nevada, Las Vegas, NV (GS); Department of Health Care Administration and Policy, School of Community Health Science, University of Nevada, Las Vegas, NV (PCK); Department of Internal Medicine, UNLV School of Medicine, Las Vegas, NV (JWY); Department of Environmental and Occupational Health, School of Community Health Sciences, University of Nevada, Las Vegas, NV (CD-F); Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea (YJL).

Objectives: To examine national trends and contributing factors of cannabis-associated emergency department visits in the United States.

Methods: This pooled serial cross-sectional study used a hierarchical multivariable analysis on emergency department visit adjusting for year, patient and hospital characteristics. We analyzed 2006 to 2014 National Emergency Department Sample data that identified cannabis-associated emergency department visits among patients aged 12 years or older (n = 265,128). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000479DOI Listing
November 2018
2 Reads

Utility of Urine Drug Testing in Outpatient Addiction Evaluations.

J Addict Med 2018 Nov 9. Epub 2018 Nov 9.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.

Objective: Data examining usefulness of urine drug testing in addiction settings for accurately establishing diagnoses and informing treatment is limited. In this retrospective-cohort study we examined the utility of performing urine drug testing in patients presenting for an outpatient addiction assessment.

Methods: Urine drug testing and patient-reported substance use history were obtained from the medical record of patients who presented for an outpatient addiction evaluation. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000477DOI Listing
November 2018
13 Reads

Correlates of Treatment Retention and Opioid Misuse Among Postpartum Women in Methadone Treatment.

J Addict Med 2018 Nov 9. Epub 2018 Nov 9.

Department of Psychiatry & Behavioral Neuroscience, Wayne State University (JDE, MC, CAS, MMC, DML, LHL); Department of Psychology, Wayne State University (JDE, CAS); Department of Psychology, University of Windsor (MC); Department of Psychology, Eastern Michigan University (MMC).

Objectives: The postpartum period is a particularly challenging time for women in methadone treatment. Unfortunately, this is also the time when women are vulnerable to treatment discontinuation and opioid misuse. The purpose of the present exploratory study was to examine demographic, treatment, and delivery factors that may be associated with postbirth retention in treatment and opioid misuse. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000467DOI Listing
November 2018
2 Reads

Escalating Opioid Dose Is Associated With Mortality: A Comparison of Patients With and Without Opioid Use Disorder.

J Addict Med 2019 Jan/Feb;13(1):41-46

University of California, Los Angeles, CA (YIH, LJM, KM, YZ, CKY, DH, DSB); Veterans Affairs Puget Sound Health Care System, Seattle, WA (AJS); University of California, San Diego, CA (DL).

Objective: Prescription Drug Monitoring Programs (PDMPs) are intended to help reduce prescription drug misuse and opioid overdose, yet little is known about the longitudinal patterns of opioid prescribing that may be associated with mortality. This study investigated longitudinal opioid prescribing patterns among patients with opioid use disorder (OUD) and without OUD in relation to mortality using PDMP data.

Methods: Growth modeling was used to examine opioid prescription data from the California PDMP for a 4-year period before death or a comparable period ending in 2014 for those remaining from a sample of 7728 patients (2576 with OUD, and 5152 matched non-OUD controls) treated in a large healthcare system. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349485PMC
January 2020
4 Reads

Are Temporal Trends Important Measures of Opioid-prescribing Risk?

J Addict Med 2019 Jan/Feb;13(1):5-6

University of Michigan, Department of Psychiatry, Injury Center, and Institute for Healthcare Policy and Innovation, Ann Arbor, MI (ASBB); Center for Clinical Management Research, Veterans Affairs Ann Arbor Medical Center, Ann Arbor, MI (ASBB); Clinical Addiction Research and Education Unit at Boston University School of Medicine and Boston Medical Center, Boston, MA (MRL).

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http://dx.doi.org/10.1097/ADM.0000000000000475DOI Listing
November 2018
9 Reads

Factors Associated With Marijuana Use Among Treatment-seeking Adult Cigarette Smokers in the Criminal Justice Population.

J Addict Med 2018 Nov 2. Epub 2018 Nov 2.

Addiction Sciences Division, University of Cincinnati College of Medicine, Cincinnati, OH (LM); Department of Psychiatry and Behavioral Neurobiology, Sparks Center 1008, Birmingham, AL (SS); Department of Psychiatry and Behavioral Neurobiology, Sparks Center 1016, Birmingham, AL (KC).

Objectives: Due to the elevated rates of cigarette use and marijuana use within the criminal justice system, it is critical to develop a stronger understanding of tobacco and marijuana co-use among this population to inform future interventions.

Methods: This study is a secondary analysis of baseline data from a smoking cessation randomized clinical trial of adults (n = 500) in a community correction program. Participants were classified as using cigarettes only or both cigarettes and marijuana through either self-report or positive urine drug screening. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000466DOI Listing
November 2018
1 Read

Pregnancy Intention, Risk Perception, and Contraceptive Use in Pregnant Women Who Use Drugs.

J Addict Med 2018 Nov 2. Epub 2018 Nov 2.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, VT (LKM); Department of Obstetrics and Gynecology and the Program on Women's Healthcare Effectiveness Research, University of Michigan, Ann Arbor, MI (VD); Departments of Obstetrics and Gynecology and Psychiatry, Virginia Commonwealth University, Richmond, VA (MT).

Objectives: The aim of the study was to evaluate pregnancy intention, risk perception, and contraceptive utilization among women reporting substance use during pregnancy.

Methods: Data were obtained from the 2009 to 2011 Tennessee Pregnancy Risk Assessment Monitoring System (PRAMS), an annual cross-sectional survey which assesses behaviors before, during and after pregnancy. Substance use during pregnancy and contraceptive use at the time of conception and after delivery were captured by self-report in the postpartum period. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000471DOI Listing
November 2018
1 Read

Toxic Leukoencephalopathy Presenting as Lethal Catatonia.

J Addict Med 2018 Nov 2. Epub 2018 Nov 2.

Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands (AMJvE, AF, JGEJ, AFAS); Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands (BSH, RAJE); and Department of Radiology, Radboud University Medical Center, Nijmegen, the Netherlands (SCAS).

Introduction: Catatonia is a syndrome that can present in different forms and can occur in multiple psychiatric and somatic conditions. This case report describes lethal catatonia caused by delayed toxic leukoencephalopathy after excessive use of cocaine and methadone. The characteristic radiographic imaging and biphasic course are discussed. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000470DOI Listing
November 2018
3 Reads

Menstrual Cycle in Women who Co-use Marijuana and Tobacco: Erratum.

Authors:

J Addict Med 2018 Nov/Dec;12(6):501

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November 2018
1 Read

Response to Urine Drug Testing in a Family Residency Practice: Erratum.

Authors:

J Addict Med 2018 Nov/Dec;12(6):501

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http://dx.doi.org/10.1097/ADM.0000000000000462DOI Listing
November 2018
1 Read

Treatment of Kratom Withdrawal and Addiction With Buprenorphine.

J Addict Med 2018 Nov/Dec;12(6):493-495

Center for Behavioral Health, Cleveland Clinic, Cleveland, OH (AK, MV); FirstHealth Moore Regional Hospital, Pinehurst, NC (JMJ); Alcohol and Drug Recovery Center, Cleveland Clinic Lutheran Hospital, Cleveland, OH (MV).

: In this article, we describe a middle-aged woman with a history of addiction to opioid medications who eventually became dependent on kratom. Her kratom-related withdrawal symptoms responded to a trial of buprenorphine-naloxone. Subsequently, she was maintained on this medication. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000435DOI Listing
November 2018
5 Reads

A Multicountry Updated Assessment of the Economic Impact of Fetal Alcohol Spectrum Disorder: Costs for Children and Adults.

J Addict Med 2018 Nov/Dec;12(6):466-473

University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND.

Aim: To conduct a systematic review and quantitative analysis of the world literature on the economic impact of fetal alcohol spectrum disorder (FASD).

Methods: A comprehensive literature review was conducted using multiple electronic databases and reference materials.

Results: Thirty-two studies from 4 countries met the inclusion criteria (United States [n = 20], Canada [n = 9], Sweden [n = 2], and New Zealand [n = 1]). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000438DOI Listing
November 2018
18 Reads

A Current Evaluation of the Economic Costs for Fetal Alcohol Spectrum Disorder (FASD): A Comment on the Systematic Review by Greenmeyer et al.

Authors:
Robert J Sokol

J Addict Med 2018 Nov/Dec;12(6):426-427

Wayne State Universiy School of Medicine, ObGyn, Detroit, MI.

: Fetal alcohol spectrum disorder is common and associated with economic costs greater than comparable other childhood and adult disorders. We need to turn our attention to prevention and mitigation. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000439DOI Listing
November 2018
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Loperamide-Associated Opioid Use Disorder and Proposal of an Alternative Treatment with Buprenorphine.

J Addict Med 2018 Oct 30. Epub 2018 Oct 30.

From the Department of Psychiatry, Maine Medical Center, Portland ME (LAW); Department of Psychiatry, Tufts University School of Medicine, Medford, MA (LAW); Department of Pharmacy, Maine Medical Center, Portland, ME (ASN); Department of Consult Liaison Psychiatry, Maine Medical Center, Portland, ME (CWR); Department of Psychiatry, Tufts University School of Medicine, Medford, MA (CWR); School of Pharmacy, Husson University, Bangor, ME (SDN); Tufts University School of Medicine, Medford, MA (SDN); Department of Pharmacy, Maine Medical Center, Portland, ME (SDN).

: This case report describes a patient with opioid use disorder who developed cardiac toxicity secondary to non-medical use of loperamide. At recommended doses, loperamide remains in the periphery to treat diarrhea. At high doses, loperamide causes central nervous system (CNS) opioid agonism. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000472DOI Listing
October 2018
7 Reads

Five-year Changes in Methamphetamine Use, Dependence, and Remission in a Community-recruited Cohort.

J Addict Med 2018 Oct 30. Epub 2018 Oct 30.

Behaviours and Health Risks Program, Burnet Institute (CL, PH, PD, BQ); Department of Epidemiology and Preventive Medicine, Monash University (CL, PD, BQ); Pre-hospital Emergency Care: Australia & New Zealand (PEC-ANZ) (DN); Department of Public Health, La Trobe University (PH); National Drug Research Institute, Faculty of Health Sciences, Curtin University (PH).

Objectives: Investigate patterns of methamphetamine use over time, specifically factors associated with remission from dependent and harmful patterns of use; and examine drug treatment and health/support service utilization pathways among people who use methamphetamine.

Methods: People who regularly use methamphetamine were recruited from nontreatment settings in Melbourne, Australia, in 2010, and followed up twice over 5 years. Trajectories of past-month methamphetamine use and methamphetamine dependence were mapped. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000469DOI Listing
October 2018
1 Read