818 results match your criteria Journal of Addiction Medicine [Journal]


Assessment of Subjective Sleep Problems in Men With Opioid Dependence Maintained on Buprenorphine.

J Addict Med 2019 Apr 3. Epub 2019 Apr 3.

National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India (RT, AD, RR, AKM, RJ, SS); Department of Medicine, All India Institute of Medical Sciences, New Delhi, India (SS).

Objectives: To assess the rates of sleep disturbances in male patients with opioid dependence maintained on buprenorphine and to assess the factors associated with sleep disturbances in this population.

Methods: Observational, cross-sectional study. Male patients with opioid dependence aged 18 years and older, and started on buprenorphine at least 6 months before were screened. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000539DOI Listing
April 2019
4 Reads
1.705 Impact Factor

Opioid Overdose in the Hospital Setting: A Systematic Review.

J Addict Med 2019 Apr 2. Epub 2019 Apr 2.

Cedars-Sinai Medical Center, Los Angeles, CA.

Objective: Our objective was to determine the percentage of opioid overdose events among medical and surgical inpatient admissions, and to identify risk factors associated with these events.

Methods: We searched PubMed and CINAHL databases from inception through July 30, 2017 and identified additional studies from reference lists and other reviews. Articles were included if they reported original research on the rate of opioid overdoses or opioid-related adverse events, and the adverse events occurred in a general medical hospital during an inpatient stay. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000536DOI Listing

Continuation in Treatment and Maintenance of Custody of Newborns After Delivery in Women With Opioid Use Disorder.

J Addict Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, Gundersen Health System, La Crosse, WI (CWS); Department of Medical Research, Gundersen Health System, La Crosse, WI (AJB, BB).

Objective: To identify variables associated with continuation in treatment and maintenance of custody after pregnancies in women with opioid use disorder (OUD).

Methods: The medical records of pregnant women with documented OUD from 2011 to 2018 and with at least 6 months follow-up postpartum were retrospectively reviewed.

Results: Via multivariate analysis, women on opioid maintenance therapy (OMT) were more likely to continue in treatment and maintain custody, whereas women enrolled in a residential treatment program during pregnancy were less likely to continue in treatment or maintain custody. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000534DOI Listing
April 2019
1 Read

Rates of and Factors Associated With Patient-reported Illicit Drug Use Screening by Health Care Professionals in the United States From 2013 to 2015.

J Addict Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA (ACS); Departments of Obstetrics & Gynecology and Psychiatry, Virginia Commonwealth University, Richmond, VA (MT).

Objectives: To examine rates of and factors associated with patient-reported illicit drug use screening by health care professionals.

Methods: The National Survey on Drug Use and Health (NSDUH), limited to individuals who reported prior year healthcare service utilization, was used to capture the odds of patient-reported illicit drug use screening for survey years 2013 to 2015. Screened patients were contrasted with those not screened by demographic and behavioral characteristics. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000537DOI Listing

Association of Marijuana, Mental Health, and Tobacco in Colorado.

J Addict Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Family Medicine, University of Colorado School of Medicine, Aurora, CO (SBS); Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO (DB, JTS, LFM); Department of Community and Behavioral Health, Colorado School of Public Health, Aurora, CO (EKB, AHL, YL); Center for Dependency, Addiction and Recovery, UCHealth, Aurora, CO (LFM); University of Colorado Cancer Center, Aurora, CO (AHL); Colorado School of Public Health, Aurora, CO (AMV); Department of Occupational and Environmental Health, Colorado School of Public Health, Aurora, CO (AMV, KAJ).

Objectives: Marijuana's evolving legality may change marijuana use patterns in adults. Co-use of marijuana and tobacco are strongly associated, and populations with mental health disorders are disproportionately likely to use either substance, but neither association has been assessed in the context of legal recreational marijuana. We assessed the associations of tobacco smoking with marijuana use and with mental health disorders in Colorado in 2015. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000533DOI Listing
April 2019
2 Reads

Cross-cultural Applicability of the 12-Step Model: A Comparison of Narcotics Anonymous in the USA and Iran.

J Addict Med 2019 Apr 1. Epub 2019 Apr 1.

Department of Psychiatry, New York University School of Medicine, New York, NY (MG); and Chestnut Health Systems, Normal, IL (WLM, BDH).

Objective: Narcotics Anonymous (NA), a nonprofessional 12-step fellowship for people seeking recovery from addiction, reports 27,677 meetings in the USA, where it was founded, but there is limited literature on its adaptability cross-culturally. We studied NA within the Islamic Republic of Iran to ascertain its relative adaptation in a different cultural setting.

Method: We surveyed 262 NA members in Iran, supplemented by member interviews, and compared demographic and substance use-related characteristics of members, and also the nature of their respective involvement in NA, to the survey results of a previous US survey (n = 527). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000526DOI Listing
April 2019
1 Read

Cannabis Use Based on Urine Drug Screens in Pregnancy and Its Association With Infant Birth Weight.

J Addict Med 2019 Mar 1. Epub 2019 Mar 1.

Department of Obstetrics and Gynecology (DSH, DND, DSL) and Hatton Research Institute, TriHealth, Cincinnati, Ohio (CGD).

Objectives: This study aims to clarify any association between infant birth weight and cannabis use in pregnancy based on urine drug screens.

Methods: A retrospective medical record review of singleton births from August 2013 through December 2014 with available urine drug screens (UDS) at initiation of prenatal care and delivery was conducted at a large tertiary academic referral center. Patients who used drugs other than cannabis were excluded. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000516DOI Listing
March 2019
3 Reads

Multimethod Formative Research to Improve the Training and Delivery of Tobacco-cessation Interventions in Behavioral Health Settings.

J Addict Med 2019 Mar 7. Epub 2019 Mar 7.

Department of Family & Community Medicine, College of Medicine-Tucson, University of Arizona, Tucson, AZ (AMA, MLM, JC, TEC, BAM, ADB).

Introduction: Despite progress in reducing tobacco use within the general population, high prevalence of tobacco use continues in individuals with mental health and substance use disorders ("clients"). Tobacco use persists as the leading cause of premature mortality in this population. While behavioral health providers have frequent contacts with this population, they lack training in tobacco cessation counseling. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000522DOI Listing

Successful Management of Gamma-hydroxybutyrate (GHB) Withdrawal Using Baclofen as a Standalone Therapy: A Case Report.

J Addict Med 2019 Mar 19. Epub 2019 Mar 19.

British Columbia Centre on Substance Use, Vancouver, BC, Canada (SH, KA, MM, MES); Department of Family Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada (SH, KA, MM); Vancouver Detox, Vancouver Coastal Health, Vancouver, BC, Canada (SH, KA, MM); Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada (MES).

Background: Gamma-hydroxybutyrate (GHB)-a GABA-B agonist-can lead to a use disorder, and a withdrawal syndrome similar to that of alcohol. At present, evidence is lacking for how to best manage GHB withdrawal, and often clinicians rely on alcohol withdrawal management approaches, using medications like benzodiazepines (BZD). However, BZD doses needed to control GHB withdrawal symptoms are typically much higher than those required for alcohol, posing significant safety risks. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000514DOI Listing
March 2019
1 Read

Immigration Status and Substance Use Disorder-related Mortality in Sweden: A National Longitudinal Registry Study.

J Addict Med 2019 Mar 14. Epub 2019 Mar 14.

Butler Institute of Families, Graduate School of Social Work, University of Denver, Denver, CO (LL, NML,TCR); Department of Social Work, Umeå University, Umeå, Sweden (LL, MBN, MP); Centre for Demography and Ageing Research (CEDAR), Umeå University, Umeå, Sweden (MP); National Board of Health and Welfare, Stockholm, Sweden (SN); Department of Psychiatry, School of Medicine, Umea University, Umeå, Sweden (MS).

Objectives: First-generation immigrants, in many countries, are healthier than their native counterparts. This study examined the association between first- and second-generation immigrant status and alcohol- or drugs other than alcohol-related (primarily opioids) mortality for those with risky substance use.

Methods: A Swedish longitudinal, 2003 to 2017, registry study combined Addiction Severity Index (ASI) assessment data with mortality data (n = 15 601). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000524DOI Listing
March 2019
6 Reads

Randomized Trial of an Innovative Electronic Screening and Brief Intervention for Reducing Drinking Among Women of Childbearing Age.

J Addict Med 2019 Mar 12. Epub 2019 Mar 12.

Alcohol Research Group, Public Health Institute, Emeryville, CA.

Objectives: To evaluate the efficacy of an innovative, self-administered, electronic Screening and Brief Intervention (e-SBI) in English and Spanish, "DrinkWise," for reducing drinking among nonpregnant women of childbearing age.

Methods: A parallel design, phase 1 trial included 185 nonpregnant women reporting risky drinking (8 or more drinks in a week or 3 or more drinks in a day) who were recruited from 2 publicly funded Nutritional Assistance for Women, Infants and Children (WIC) program sites in the United States from 2016 to 2017. Participants were 18 to 44 years in age, 75% of Hispanic ethnicity, 44% Spanish speakers, 30% had not completed high school, and 15% were currently breastfeeding. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000518DOI Listing

Temporal Trends in Opioid References in Popular Hip-Hop Song Lyrics.

J Addict Med 2019 Mar 12. Epub 2019 Mar 12.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada Division of Cardiology, London Health Sciences Centre, Western University, London, Ontario, Canada Department of Social and Preventive Medicine, Université Laval, Québec, QC, Canada.

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http://dx.doi.org/10.1097/ADM.0000000000000528DOI Listing
March 2019
1 Read

A Pilot Crossover Trial of Sleep Medications for Sleep-disturbed Methadone Maintenance Patients.

J Addict Med 2019 Mar 9. Epub 2019 Mar 9.

Butler Hospital, Providence, RI (MDS, MEK, BJA, CEB); Warren Alpert Medical School of Brown University, Providence, RI (MDS, CEB); and Boston University School of Public Health, Boston, MA (MDS).

Objectives: Problems with sleep are a common and detrimental occurrence among individuals who receive methadone maintenance for opioid use disorder (OUD).

Methods: We enrolled ten methadone-maintained persons with insomnia (60% female, mean age 40) in a double-blind trial using actigraphy to confirm daily sleep reports. After a no-medication week to establish baseline sleep patterns, each participant received 1 week each of mirtazapine (30 mg), zolpidem (sustained-release 12. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000531DOI Listing
March 2019
2 Reads

Screening, Brief Intervention, and Referral to Treatment in a Retail Pharmacy Setting: The Pharmacist's Role in Identifying and Addressing Risk of Substance Use Disorder.

J Addict Med 2019 Mar 9. Epub 2019 Mar 9.

The Recovery Research Network Foundation, Atlantis, FL (BCS, SG, RMG), Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN (BCS), Palm Beach Atlantic University, Lloyd L. Gregory School of Pharmacy, West Palm Beach, FL (DW, ED), Atlantis Pharmacy, Atlantis, FL (DS, ED).

Objective: This study determined the feasibility of interviewing and screening patients presenting to a retail pharmacy using Screening, Brief Intervention, and Referral to Treatment (SBIRT) interview protocols, and to compare SBIRT results to a risk score calculated from Prescription Drug Monitoring Program (PDMP) data.

Methods: Using the NIDA Quick Screen and NIDA Modified-ASSIST (NM-ASSIST) and the Alcohol Use Disorder Identification Test (AUDIT), retail pharmacy customers were screened for substance and alcohol use disorder and tobacco use. PDMP reports were collected on subjects and a PDMP-risk score was calculated based on the numbers of Schedule II-V prescriptions and prescribers over the previous 12 months. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000525DOI Listing
March 2019
1 Read

Disparities Between US Opioid Overdose Deaths and Treatment Capacity: A Geospatial and Descriptive Analysis.

J Addict Med 2019 Mar 4. Epub 2019 Mar 4.

University of Texas Health Science Center at Houston, Houston, TX.

Introduction: With opioid-related deaths reaching epidemic levels, gaining a better understanding of access to treatment for opioid use disorder (OUD) is critical. Most studies have focused on 1 side of the equation-either provider capacity or patients' need for care, as measured by overdose deaths. This study examines the overlay between treatment program availability and opioid mortality, comparing accessibility by region. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000523DOI Listing

Patient-centered Outcomes in Participants of a Buprenorphine Monthly Depot (BUP-XR) Double-blind, Placebo-controlled, Multicenter, Phase 3 Study.

J Addict Med 2019 Mar 4. Epub 2019 Mar 4.

UCLA David Geffen School of Medicine, Department of Family Medicine, Center for Behavioral & Addiction Medicine, Los Angeles, CA (WL); Indivior Inc., Richmond, VA (VRN, SML, CH); Pharmerit International, Bethesda, MD (CTS); RTI Health Solutions, Research Triangle Park, NC (NAR); Pharmerit International, Newton, MA (YCY); Artemis Institute for Clinical Research, San Diego, CA (VM).

Objective: Opioid use disorder (OUD) is associated with physical, social, psychological, and economic burden. This analysis assessed the effects of RBP-6000, referred to as BUP-XR (extended-release buprenorphine), a subcutaneously injected, monthly buprenorphine treatment for OUD compared with placebo on patient-centered outcomes measuring meaningful life changes.

Methods: Patient-centered outcomes were collected in a 24-week, phase 3, placebo-controlled study assessing the efficacy, safety, and tolerability of BUP-XR 300/300 mg (6 × 300 mg) and 300/100 mg (2 × 300 mg followed by 4 × 100 mg) injections in treatment-seeking participants with moderate-to-severe OUD. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000517DOI Listing
March 2019
5 Reads

Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction.

J Addict Med 2019 Mar 4. Epub 2019 Mar 4.

Dr Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Tel Aviv Sourasky Medical Center (EP, MA); Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel (EP); The Laboratory of the Biology of Addictive Diseases (OL, MR, MJK, MA); The Laboratory of Statistical Genetics, The Rockefeller University, New York, NY (JO); Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Las Vegas, NV (MA).

Objectives: We have previously shown associations between 4 genetic variants in opioid and stress-related genes (OPRM1, NPYR1/NPYR5, NR3C1, and CRHBP) and prolonged abstinence from heroin without methadone maintenance treatment (MMT). We currently assessed the associations between these variants and MMT patients' characteristics.

Methods: A non-selective group of 351 patients who stayed at least 1 year in their first admission to MMT were genotyped and their characteristics and substance in urine on admission and after 1 year were studied. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000515DOI Listing
March 2019
2 Reads

Prescribing of Opioids and Benzodiazepines Among Patients With History of Overdose.

J Addict Med 2019 Mar 4. Epub 2019 Mar 4.

Atrium Health Musculoskeletal Institute, Department of Orthopaedic Surgery, Carolinas Trauma Network Research Center of Excellence, Atrium Health, Charlotte, NC (MKW, JRH, RBS, MJB, RF, EH, DL, SS); Poison Information Center, Atrium Health, Charlotte, NC (MB); Department of Emergency Medicine, Carolinas Trauma Network Research Center of Excellence, Atrium Health, Charlotte, NC (CG, MR, MG); Patient Safety, Atrium Health, Charlotte, NC, USA (SJ); Department of Internal Medicine, Atrium Health, Charlotte, NC (AS); US Acute Care Solutions, Atrium Health, Pineville, NC (BW); Adult Psychiatry, Atrium Health, Charlotte, NC (SW).

Objectives: Addiction and overdose related to prescription drugs continues to be a leading cause of morbidity and mortality in the United States. We aimed to characterize the prescribing of opioids and benzodiazepines to patients who had previously presented with an opioid or benzodiazepine overdose.

Methods: This was a retrospective chart review of patients who were prescribed an opioid or benzodiazepine in a 1-month time-period in 2015 (May) and had a previous presentation for opioid or benzodiazepine overdose at a large healthcare system. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000513DOI Listing
March 2019
5 Reads

Psychotropics in Your Medicine Cabinet: A Case Study of Dimenhydrinate Use.

J Addict Med 2019 Mar 4. Epub 2019 Mar 4.

University of Toronto, Faculty of Medicine (XW); Centre of Addiction and Mental Health, Addictions Division (FDP, NC); University of Toronto, Department of Family & Community Medicine (FDP); University of Toronto, Department of Psychiatry, Ontario, Canada (NC).

: Reporting of intoxication and withdrawal from aberrant use of over-the-counter medication has been sparse and inconsistent in literature. Attributed to their anticholinergic properties, medications such as dimenhydrinate (Gravol) taken in supratherapeutic doses have been associated with euphoria, anxiolysis, and hallucinations. We present a case of a woman in her forties, with a psychiatric history of bipolar disorder, and complex concurrent medical history including familial Mediterranean fever (FMF), and fibromyalgia, admitted for withdrawal management of her intravenous dimenhydrinate use. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000511DOI Listing
March 2019
1 Read

Adverse Events During Treatment Induction With Injectable Diacetylmorphine and Hydromorphone for Opioid Use Disorder.

J Addict Med 2019 Feb 7. Epub 2019 Feb 7.

Centre for Health Evaluation & Outcome Sciences, Providence Health Care, St. Paul's Hospital (EOJ, HP, DG, AHA, MTS); School of Population and Public Health, University of British Columbia, Vancouver, BC (EOJ, HP, AHA, MTS); Northern Ontario School of Medicine, Sudbury, ON (DCM); Canadian Addiction Treatment Centres, Markham, ON (DCM); Providence Health Care, Providence Crosstown Clinic, Vancouver, BC (SH, SM); Centre Hospitalier de l'Université de Montréal, Hôpital Saint-Luc, CHUM Montréal, Montréal, QC, Canada (SB).

Objectives: The present study aims to describe a 3-day induction protocol for injectable hydromorphone (HDM) and diacetylmorphine (DAM) used in 3 Canadian studies and examine rates of opioid-related overdose and somnolence during this induction phase.

Methods: The induction protocol and associated data on opioid-related overdose and somnolence are derived from 2 clinical trials and one cohort study conducted in Vancouver and Montreal (2005-2008; 2011-2014; 2014-2018). In this analysis, using the Medical Dictionary for Regulatory Activities coding system we report somnolence (ie, drowsiness, sleepiness, grogginess) and opioid overdose as adverse events. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000505DOI Listing
February 2019

Initiation and Rapid Titration of Methadone in an Acute Care Setting for the Treatment of Opioid Use Disorder: A Case Report.

J Addict Med 2019 Feb 5. Epub 2019 Feb 5.

British Columbia Centre on Substance Use, Vancouver, BC (PH, PB, KC, SN); Department of Medicine, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada (PH, PB, SN).

Background: Although methadone is an effective treatment for opioid use disorder, its initiation requires prescribing at a subtherapeutic dose with subsequent titration to a therapeutic dose over many weeks. Accordingly, the methadone induction period can be a challenging one for individuals and can be associated with an increased risk for ongoing illicit drug use and consequently overdose. Given its capacity for regular clinical assessments, acute care settings may offer a unique opportunity to reduce the duration of the induction period for methadone maintenance therapy. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000507DOI Listing
February 2019
5 Reads

Evaluation of the Brief Alcohol Withdrawal Scale Protocol at an Academic Medical Center.

J Addict Med 2019 Feb 6. Epub 2019 Feb 6.

Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, MD (BKL, VTG, RMK, ASJ); Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (AAHA, TN); Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (ESC); Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD (PM, KP); Center for Chemical Dependence, Johns Hopkins Bayview Medical Center, Baltimore, MD (DAR); Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD (SY).

Objectives: The standard of care for treatment of alcohol withdrawal is symptom-triggered dosing of benzodiazepines using a withdrawal scale. Abbreviated scales are desired for clinician efficiency. The objective of this study was to evaluate the use of the 5-item Brief Alcohol Withdrawal Scale (BAWS) protocol. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000510DOI Listing
February 2019
18 Reads

Severity of Analgesic Dependence and Medication-overuse Headache.

J Addict Med 2019 Feb 1. Epub 2019 Feb 1.

Research Centre, Akershus University Hospital, Lørenskog (CL, ESK); Department of Neurology, Akershus University Hospital, Nordbyhagen (CL, ESK); Institute of Clinical Medicine, Campus Akershus University Hospital, University of Oslo, Nordbyhagen, Norway (CL, MBR); National Addiction Centre, King's College, London, UK (MG); Head and Neck Research Group, Research Centre, Akershus University Hospital, Lørenskog (MBR); Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway (JS, ESK).

Background And Aims: Medication-overuse headache (MOH) is a common chronic headache caused by overuse of headache analgesics. It has similarities with substance dependence disorders. The treatment of choice for MOH is withdrawal of the offending analgesics. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000504DOI Listing
February 2019
1 Read

Medication Adherence Monitoring Using Smartphone Video Dosing in an Open-label Pilot Study of Monthly Naltrexone Plus Once-daily Bupropion for Methamphetamine Use Disorder: Feasibility and Acceptability.

J Addict Med 2019 Feb 1. Epub 2019 Feb 1.

University of Texas Southwestern Medical Center, Dallas, TX (RW); New York University, New York, NY (MH, BP); UCLA Integrated Substance Abuse Programs, Los Angeles, CA (BP, LM, WL); Retired from: National Institute on Drug Abuse Center for the Clinical Trials Network, Rockville, MD (SP).

Objectives: This article describes how smartphones were used to monitor and encourage medication adherence in a pilot study evaluating the potential efficacy of a combination pharmacotherapy for methamphetamine use disorder. We examine the feasibility, utility, and acceptability of using smartphones to capture dosing videos from the perspectives of participants and staff.

Methods: The study was an 8-week, open-label evaluation of extended-release injectable naltrexone combined with once-daily oral extended-release bupropion (BRP, Welbutrin XL, 450 mg/day). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000509DOI Listing
February 2019
1 Read

Reply to Dr Howe.

Authors:
Sharon S Allen

J Addict Med 2019 Jan/Feb;13(1):81-82

University of Minnesota Twin Cities, Minneapolis, MN.

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http://dx.doi.org/10.1097/ADM.0000000000000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363481PMC
January 2020

Pilot Trial of a Combined Cognitive Processing Therapy and Smoking Cessation Treatment.

J Addict Med 2019 Jan 17. Epub 2019 Jan 17.

Durham Veterans Affairs Medical Center, Durham, NC (EAD, PAD, SMW, SDM, JCB); Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC (EAD, PAR, SMW, SDM, JCP); Veterans Affairs Mid-Atlantic Region Mental Illness Research, Education, and Clinical Center, Durham, NC (EAD, PAD, SDM, JCB); Veterans Affairs Center of Innovation to Accelerate Discovery and Practice Transformation, Durham, NC (SMW).

Objective/background: Posttraumatic stress disorder (PTSD) and smoking are often comorbid. Combining PTSD and smoking cessation treatments could increase access to each treatment and could provide improved rates of smoking cessation through reductions in PTSD and depressive symptoms.

Participants: Participants were veterans with current PTSD who smoked cigarettes and were willing to initiate treatment for both problems. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000502DOI Listing
January 2019
4 Reads

Treatment for Opioid Addiction Must Be Offered in General Hospitals: But How?

Authors:
Richard Saitz

J Addict Med 2019 Mar/Apr;13(2):83-84

Boston University Schools of Public Health & Medicine/Boston Medical Center, Boston, MA.

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http://dx.doi.org/10.1097/ADM.0000000000000501DOI Listing
January 2019
8 Reads

Alcohol Drinking in Chinese Methadone-maintained Clients: A Self-medication for Depression and Anxiety?

J Addict Med 2019 Jan 4. Epub 2019 Jan 4.

Research Center for Psychological and Health Sciences, China University of Geosciences, Wuhan, Hubei Province, China (B-LZ); Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, Hubei Province, China (B-LZ, Y-MX); Peking University Clinical Research Institute, Peking University Health Science Center, Beijing, China (W-XX); Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China (JL); Yidu Cloud (Beijing) Technology Co., Ltd., Beijing, China (W-BY, JY).

Objectives: Unhealthy alcohol use is associated with negative health outcomes in clients attending methadone maintenance therapy (MMT) programs. However, debates exist regarding the methadone dose of drinkers, and little is known about the health outcomes of drinkers with other types of alcohol use. This study examined the drinking pattern and its association with methadone dose, and depressive and anxiety symptoms in Chinese clients undergoing MMT. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000500DOI Listing
January 2019
19 Reads

Hospital-Based Addiction Medicine Healthcare Providers: High Demand, Short Supply.

J Addict Med 2019 Jan 4. Epub 2019 Jan 4.

British Columbia Centre on Substance Use (VB, SN); Department of Medicine, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada (SN).

: Substance use disorders account for a significant burden of disease and place an enormous strain on the health care system in the United States and beyond. Despite death tolls climbing, a myriad of evidence-based medications exist to effectively treat many substance use disorders including nicotine, alcohol, and opioid use disorders. To date, hospitals have largely been overlooked as a setting ripe for the delivery of specialized addiction care. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000488DOI Listing
January 2019
13 Reads

Recovery Goals and Long-term Treatment Preference in Persons Who Engage in Nonmedical Opioid Use.

J Addict Med 2019 Jan 4. Epub 2019 Jan 4.

Behavioral Pharmacology Research Unit, Johns Hopkins School of Medicine, Baltimore, MD (KRH, ASH, DAT, KED); Department of Psychiatry, UCSF School of Medicine, San Francisco, CA (DAT).

Background: While most opioid use disorder (OUD) treatment providers consider opioid abstinence to be the preferred outcome, little is known about the treatment preferences of the larger population of individuals who engage in nonmedical opioid use and have not yet sought treatment. This study sought to descriptively quantify the proportion of out-of-treatment individuals with nonmedical opioid use that have abstinent and nonabstinent recovery goals.

Methods: Participants (N = 235) who engage in nonmedical opioid use and met self-reported criteria for OUD were recruited online and participated in a cross-sectional survey on recovery goals and treatment perceptions. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000498DOI Listing
January 2019
3 Reads

Predictors for 30-Day and 90-Day Hospital Readmission Among Patients With Opioid Use Disorder.

J Addict Med 2019 Jan 8. Epub 2019 Jan 8.

Department of Quality Management and Patient Safety, Beaumont Health, Southfield, MI (JLM); Substance Use Disorders Initiative, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA (SEW); School of Pharmacy, Northeastern University, Boston, MA (MSD); Department of Pharmacy, Massachusetts General Hospital, Boston, MA (RJR); Department of Health Sciences, Northeastern University, Boston, MA (JSJ); School of Pharmacy, Northeastern University, Boston, MA (JWD).

Objectives: To identify the incidence, characteristics, and predictors for 30 and 90-day readmission among acutely hospitalized patients with opioid use disorder (OUD).

Methods: This retrospective, cohort study evaluated consecutive adults with OUD admitted to an academic medical center over a 5-year period (10/1/11 to 9/30/16). Multivariable logistic regression was used to determine independent predictors for 30 and 90-day readmissions based on pertinent admission, hospital, and discharge variables collected via chart review and found to be different (with a P < 0. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000499DOI Listing
January 2019
7 Reads

Role of the Hospital in the 21st Century Opioid Overdose Epidemic: The Addiction Medicine Consult Service.

J Addict Med 2019 Mar/Apr;13(2):104-112

Oregon Health & Science University (OHSU) and Portland State University School of Public Health (KCP, DM), School of Medicine, MD/PhD Program, OHSU (KCP), Department of Psychiatry, School of Medicine, OHSU, Portland, OR (DM).

Objective: The aim of the study was to explore and describe the structure and design elements of addiction medicine consult (AMC) services within selected US hospitals.

Methods: As part of a larger mixed methods study, 10 qualitative semi-structured telephone interviews were completed with board-certified addiction medicine physicians affiliated with the Addiction Medicine Foundation's Addiction Medicine Fellowship Programs at 9 US hospitals. Interviews were transcribed, coded, and analyzed using a directed content analysis. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417955PMC
March 2020
2 Reads

Tools to Support Hospital-Based Addiction Care: Core Components, Values, and Activities of the Improving Addiction Care Team.

J Addict Med 2019 Mar/Apr;13(2):85-89

Oregon Health & Science University, Portland, OR.

: Hospitals are increasingly filled with people admitted for medical and surgical complications of substance use disorder (SUD). Hospitalization can be a reachable moment to engage and initiate SUD care. Yet most hospitals do not have systems in place to adequately address addiction, and most providers have little to no addiction training. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000487DOI Listing
January 2019
30 Reads

Prevalence, Incidence, and Factors Associated With Substance Use Among Medical Students: A 2-Year Longitudinal Study.

J Addict Med 2018 Dec 27. Epub 2018 Dec 27.

School of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

Objectives: Although there are a number of studies about substance use by medical students, the majority are still cross-sectional. We aimed to investigate prevalence, 2-year incidence, and factors associated with substance use during medical training.

Methods: This longitudinal study included medical students in 4 different waves (with each wave equaling 1 semester). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000497DOI Listing
December 2018
2 Reads

Toward Gender-inclusive, Nonjudgmental Alcohol Interventions for Pregnant People: Challenging Assumptions in Research and Treatment.

J Addict Med 2018 Dec 27. Epub 2018 Dec 27.

Institute for Gender, Race, Sexuality and Social Justice, University of British Columbia, British Columbia, Canada (AJL); School of Population and Public Health, University of British Columbia, British Columbia, Canada (AJL); British Columbia Centre on Substance Use, Vancouver, Canada (RK); Department of Medicine, University of British Columbia, Vancouver, Canada (RK).

: Epidemiological and clinical evidence clearly indicates that binge and/or heavy alcohol use while pregnant can be dangerous for the fetus. As such, there is a large body of research evaluating interventions to address harms associated with alcohol use during pregnancy. Unfortunately, based on our assessment of the scientific literature in this area, including a reading of three high-impact systematic reviews, there are several key areas where the language being used is hindering efforts to address alcohol harms during pregnancy in nonjudgmental and gender-inclusive ways. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000495DOI Listing
December 2018
2 Reads

Technology Use Patterns Among Patients Enrolled in Inpatient Detoxification Treatment.

J Addict Med 2018 Dec 20. Epub 2018 Dec 20.

NYU College of Nursing (NL); NYU Department of Population Health (JDL, BT, PG); Johns Hopkins School of Public Health (AH); National Development and Research Institutes, Inc, New York, NY (MCA).

Background: Technology-based interventions offer a practical, low-cost, and scalable approach to optimize the treatment of substance use disorders (SUDs) and related comorbidities (HIV, hepatitis C infection). This study assessed technology use patterns (mobile phones, desktop computers, internet, social media) among adults enrolled in inpatient detoxification treatment.

Methods: A 49-item, quantitative and qualitative semi-structured survey assessed for demographic characteristics, technology use patterns (ie, mobile phone, text messaging [TM], smart phone applications, desktop computer, internet, and social media use), privacy concerns, and barriers to technology use. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000494DOI Listing
December 2018
2 Reads

Naloxone Availability and Pharmacy Staff Knowledge of Standing Order for Naloxone in Pennsylvania Pharmacies.

J Addict Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Emergency Medicine, Perelman School of Medicine (RLG, JP, FS, RMM, ZFM); Leonard Davis Institute of Health Economics (EA, ZFM); Penn Medicine Center for Digital Health, University of Pennsylvania, Philadelphia, PA (RMM).

Objective: To assess the availability and price of naloxone as well as pharmacy staff knowledge of the standing order for naloxone in Pennsylvania pharmacies.

Methods: We conducted a telephone audit study from December 2016 to April 2017 in which staff from Pennsylvania pharmacies were surveyed to evaluate naloxone availability, staff understanding of the naloxone standing order, and out-of-pocket cost of naloxone.

Results: Responses were obtained from 682 of 758 contacted pharmacies (90% response rate). Read More

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http://dx.doi.org/10.1097/ADM.0000000000000492DOI Listing
December 2018
2 Reads

"I didn't want to be on Suboxone at first…"- Ambivalence in Perinatal Substance Use Treatment.

J Addict Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Research, UNC Health Sciences at MAHEC; University of North Carolina-Asheville; Department of Family Medicine, Boston University School of Medicine (BO); UNC Health Sciences at MAHEC (CL).

Objectives: The objectives of this article are to present findings from recent qualitative research with patients in a combined perinatal substance use treatment program in Central Appalachia, and to describe and analyze participants' ambivalence about medication-assisted treatment for opioid use disorder (OUD), in the context of widespread societal stigma and judgement.

Methods: We conducted research in a comprehensive outpatient perinatal substance use treatment program housed in a larger obstetric practice serving a large rural, Central Appalachian region. The program serves patients across the spectrum of substance use disorders but specifically offers medication-assisted treatment to perinatal patients with OUD. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000491DOI Listing
December 2018
3 Reads

Opioid and Cannabis Co-Use among Adults with Chronic Pain: Relations to Substance Misuse, Mental Health, and Pain Experience.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, University of Houston, Houston, TX (AHR, JB, DJP, MJV); Department of Psychology, Louisiana State University, Baton Rouge, LA (JDB); College of Nursing, Washington State University, Washington, DC (MFO); Department of Psychology, Syracuse University, New York, NY (JWD); Department of Behavioral Science, The University of Texas MD Anderson Cancer Center (MJZ); and HEALTH Institute, University of Houston, Houston, TX (MJZ).

Objectives: Opioid misuse constitutes a significant public health problem and is associated with a host of negative outcomes. Despite efforts to curb this increasing epidemic, opioids remain the most widely prescribed class of medications. Prescription opioids are often used to treat chronic pain despite the risks associated with use, and chronic pain remains an important factor in understanding this epidemic. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000493DOI Listing
December 2018
13 Reads

Use of Buprenorphine-Naloxone in the Treatment of Tianeptine Use Disorder.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Spectrum Health, Center for Integrative Medicine, Grand Rapids, MI (PT); Boston University Department of Medicine, Section of General Internal Medicine, Clinical Addiction Research and Education Unit, School of Medicine & Boston Medical Center, Boston, MA (AYW).

: Tianeptine is an atypical antidepressant which exerts an opioid-like effect on the μ-opioid receptor. There is well documented intentional misuse and addiction to tianeptine in Europe, and this is increasingly being seen in the United States. We presented a case of buprenorphine/naloxone successfully being used to aid in cessation and subsequent abstinence from tianeptine after years of use. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000490DOI Listing
December 2018
3 Reads

Obstetric and Pediatric Provider Perspectives on Mandatory Reporting of Prenatal Substance Use.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health (MJ); University of Pittsburgh School of Medicine (SM, CH); Magee-Womens Research Institute, University of Pittsburgh (JCC); Departments of Obstetrics, Gynecology and Reproductive Sciences and Internal Medicine, University of Pittsburgh, Pittsburgh, PA (JCC).

Objective: In many states, health care providers are legally required to report pregnant women who use substances, or infants affected by prenatal substance use, to child welfare authorities. The objective of this study was to characterize obstetric and pediatric providers' perceptions of and experiences with policies requiring mandatory reporting of prenatal substance use to child welfare authorities.

Methods: We conducted a qualitative interview study among 20 obstetric and pediatric providers to elicit participants' perspectives about and experience with current policy requiring mandatory reporting of prenatal substance use. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000489DOI Listing
December 2018
9 Reads

Impact of Fentanyl Use on Buprenorphine Treatment Retention and Opioid Abstinence.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Division of General Internal Medicine, Massachusetts General Hospital (SEW, YC, SR, LY, JM, NR); Harvard Medical School (SEW, YC, SR, JF, JM, NR); Department of Pathology, Massachusetts General Hospital, Boston, MA (JF).

Objectives: There has been a rapid increase in the presence of illicitly manufactured fentanyl in the heroin drug supply. Buprenorphine is an effective treatment for heroin and prescription opioid use disorder; however, little is known about treatment outcomes among people using fentanyl. We compared 6-month treatment retention and opioid abstinence among people initiating buprenorphine treatment who had toxicology positive for heroin compared to fentanyl at baseline. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000486DOI Listing
December 2018
2 Reads

Evaluating the Impact of Prescribed Versus Nonprescribed Benzodiazepine Use in Methadone Maintenance Therapy: Results from a Population-based Retrospective Cohort Study.

J Addict Med 2018 Dec 12. Epub 2018 Dec 12.

Institute for Clinical and Evaluative Sciences, Toronto, Ontario, Canada (JKE, ASW, PK); Centre for Addiction and Mental Health, Toronto, Ontario, Canada (PK); Northern Ontario School of Medicine, Sudbury, Ontario, Canada (JKE, AMF, DCM).

Objectives: Benzodiazepine (BZD) use is common in patients who are engaged in methadone as a treatment for opioid use disorder. BZD prescribing is generally discouraged for this patient population due to the increased risk of BZD dependence and BZD use disorder, medication-assisted treatment (MAT) discontinuation, and opioid-overdose death. However, some patients have concurrent mental health disorders, where BZD use may be clinically indicated. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000476DOI Listing
December 2018
18 Reads

Buprenorphine Pharmacology Review: Update on Transmucosal and Long-acting Formulations.

J Addict Med 2019 Mar/Apr;13(2):93-103

Department of Pharmacology, College of Medicine, University of Kentucky, Lexington, KY (MAC, SLW); Department of Behavioral Science, University of Kentucky, Lexington, KY (MRL, SLW); and Center on Drug and Alcohol Research, University of Kentucky, Lexington, KY (MAC, MRL, SLW).

: Buprenorphine is an effective treatment for opioid use disorder. As a high-affinity, partial agonist for the mu-opioid receptor, buprenorphine suppresses opioid withdrawal and craving, reduces illicit opioid use, and blocks exogenous opioid effects including respiratory depression. Other pharmacologic benefits of buprenorphine are its superior safety profile compared with full opioid agonists and its long half-life that allows daily or less-than-daily dosing. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000457DOI Listing
December 2018
5 Reads

Idiopathic Thrombocytopenic Purpura Induced by Synthetic Cannabinoid.

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Internal Medicine (CC, KR, YG, ZF, MM); Department of Hematology (AP-P); Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL (SJC).

: Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder defined as low platelet count with normal bone marrow in the absence of other causes of thrombocytopenia. It is caused by autoantibodies binding to several platelet surface antigens which lead to premature destruction of the platelet by the reticuloendothelial system. ITP can be primary or secondary, and it is known to be associated with various infections and drugs. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000485DOI Listing
November 2018
6 Reads

Safety and Efficacy of Lofexidine for Medically Managed Opioid Withdrawal: A Randomized Controlled Clinical Trial.

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry, Johns Hopkins School of Medicine and Maryland Treatment Centers, Baltimore, MD (MF); CARMA Health, PLLC, Austin, TX (CT); Northwestern Medicine Central DuPage Hospital, Winfield, IL (DA); Pharmaceutical Development and Regulatory Affairs, US WorldMeds, LLC, Louisville, KY (KG); Biometrics, US WorldMeds, LLC, Louisville, KY (TC); Consultant to US WorldMeds, LLC, Louisville, KY (CWG).

Objectives: To investigate the safety and efficacy of lofexidine for treating opioid withdrawal syndrome (OWS) and facilitating completion of opioid withdrawal.

Methods: A multicenter, double-blind, placebo-controlled study was conducted at 18 US centers from June 2013 to December 2014. Participants (n = 603) aged ≥18 years, dependent on short-acting opioids, and seeking withdrawal treatment, randomized 3:3:2 to receive lofexidine 2. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000474DOI Listing
November 2018
5 Reads

Lofexidine for Opioid Withdrawal: Small Effects at an Exorbitant Price.

Authors:
David N Juurlink

J Addict Med 2018 Nov 29. Epub 2018 Nov 29.

Divisions of General Internal Medicine and Clinical Pharmacology & Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, and the University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/ADM.0000000000000473DOI Listing
November 2018
5 Reads

Comparison of Perioperative Systemic Lidocaine or Systemic Ketamine in Acute Pain Management of Patients With Opioid Use Disorder After Orthopedic Surgery.

J Addict Med 2018 Nov 28. Epub 2018 Nov 28.

Shiraz Anesthesiology and Intensive Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction And Aims: Patients with opioid use disorder experience great challenges during acute pain management due to opioid tolerance or withdrawal symptoms. Previous studies have recommended the use of adjuvant drugs in these patients. In this study, we compared the effect of intraoperative lidocaine with ketamine in postoperative pain management of these patients. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000483DOI Listing
November 2018
5 Reads

Impact of In-utero Exposure to Selective Serotonin Reuptake Inhibitors and Opioids on Neonatal Opioid Withdrawal Syndrome.

J Addict Med 2018 Nov 21. Epub 2018 Nov 21.

Department of Clinical Pharmacy, College of Pharmacy (VB-M); Department of Pediatrics, Michigan Medicine, University of Michigan (VB-M, JS, RES); Department of Pharmacy, Ascension St. John Hospital, Ann Arbor, MI (JR).

Objective: The objective of this study was to compare short-term outcomes of neonatal opioid withdrawal syndrome (NOWS) treatment in infants exposed in-utero to opioids and selective serotonin reuptake inhibitors (SSRIs) or opioids alone.

Methods: This was a retrospective cohort study of mother-infant dyads, 34 weeks or greater gestation, receiving opioids and/or SSRIs during pregnancy. Intravenous or oral methadone was administered according to a pre-existing protocol for NOWS treatment guided by withdrawal scores. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000484DOI Listing
November 2018
2 Reads