518,214 results match your criteria Joint Commission journal on quality and patient safety / Joint Commission Resources[Journal]


Diabetes mellitus, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Genetic variation in the insulin-like growth factor (IGF) pathway may further increase the risk of colorectal cancer (CRC) associated with type 2 diabetes mellitus (T2DM). Joint effects of T2DM and genetic variation in the IGF pathway on CRC risk can increase mechanistic insights. Participants from the Netherlands Cohort Study (n=120,852) completed a baseline questionnaire in 1986 when 55-69 years old (case-cohort, n subcohort=5,000, n cases = 3,441 after 16. Read More

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http://dx.doi.org/10.1002/ijc.32365DOI Listing

Maintenance of Integrity of Upper Facet Joints during Simulated Percutaneous Pedicle Screw Insertion Using 2D versus 3D Planning.

J Neurol Surg A Cent Eur Neurosurg 2019 Apr 24. Epub 2019 Apr 24.

Department of Neurosurgery, University of Mainz, Mainz, Germany.

Background:  No studies have directly and quantitatively compared two-dimensional (2D) and three-dimensional (3D) planning as applied during conventional percutaneous or navigated percutaneous pedicle screw placement.

Study Aims:  This lumbar pedicle-based stabilization simulation study aimed to investigate the risk of upper facet joint violation (FJV) during posterior percutaneous pedicle screw placement with conventional 2D planning of screw implantation (as a model for fluoroscopically guided screws) compared with 3D planning (as used with navigation techniques).

Methods:  The placement of monosegmental lumbar pedicle screws using the data sets of 250 consecutive patients was simulated. Read More

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http://dx.doi.org/10.1055/s-0039-1681042DOI Listing

Ultra-efficient spin-orbit torque induced magnetic switching in W/CoFeB/MgO structures.

Nanotechnology 2019 Apr 24. Epub 2019 Apr 24.

Fert Beijing Institute, Beihang University, Beijing, 100193, CHINA.

The spin-orbit torque (SOT) induced magnetic switching in heavy metal/ferromagnet (HM/FM) structures with perpendicular magnetic anisotropy (PMA) is promising for energy-efficient spintronic devices. Here, we studied the SOT induced magnetic switching in perpendicular W/Co20Fe60B20/MgO structures. We demonstrated the critical current density for the SOT induced switching is as low as 1. Read More

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http://dx.doi.org/10.1088/1361-6528/ab1c02DOI Listing

Ultrathin 2D Rare-Earth Nanomaterials: Compositions, Syntheses, and Applications.

Adv Mater 2019 Apr 24:e1806461. Epub 2019 Apr 24.

Tianjin Key Lab for Rare Earth Materials and Applications, Center for Rare Earth and Inorganic Functional Materials, School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin, 300350, P. R. China.

Ultrathin 2D nanomaterials possess promising properties due to electron confinement within single or a few atom layers. As an emerging class of functional materials, ultrathin 2D rare-earth nanomaterials may incorporate the unique optical, magnetic, and catalytic behaviors of rare-earth elements into layers, exhibiting great potential in various applications such as optoelectronics, magnetic devices, transistors, high-efficiency catalysts, etc. Despite its importance, reviews on ultrathin 2D rare-earth nanomaterials or related topics are rare and only focus on a certain family of ultrathin 2D rare-earth nanomaterials. Read More

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http://dx.doi.org/10.1002/adma.201806461DOI Listing

The relationship between motivations for cannabis consumption and problematic use.

Adicciones 2019 Apr 8;0(0):1221. Epub 2019 Apr 8.

Grup de Recerca en Addiccions Clínic (GRAC-GRE). Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS Hospital Clínic i Universitari de Barcelona. Universitat de Barcelona). Barcelona.

Introduction: Systematic screening of problematic cannabis use does not include the motivations that lead to consumption, although from a person-centered perspective this is fundamental. The present study explores the motivations for cannabis use in adults and its relationship with cannabis use patterns and problematic use.

Method: Adult cannabis users (previous 60 days) were recruited in the province of Barcelona (n = 468). Read More

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http://dx.doi.org/10.20882/adicciones.1221DOI Listing

Declining Proportion of Incident Squamous Cell Carcinomas of the Oral Cavity Coded as Unknown for American Joint Committee TNM Stage:SEER Registries, 2004-2014.

J Registry Manag 2018 ;45(3):104-108

Background: For squamous cell carcinomas of the oral cavity (OCSCC), American Joint Committee on Cancer (AJCC) TNM stage at diagnosis is widely used by clinicians. In US cancer registries, AJCC 6th edition stage was derived by computer algorithm from codes based on the Collaborative Stage System (CSS) for diagnoses from 2004-2015, but unknown stage is an issue.

Methods: A research database of population-based Surveillance, Epidemiology, and End Results (SEER) Program registries (covering about 28% of the US population) included AJCC stage for diagnoses in 2004-2014. Read More

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January 2018

Visual Perception of Joint Stiffness from Multi-Joint Motion.

J Neurophysiol 2019 Apr 24. Epub 2019 Apr 24.

Mechanical Engineering and Brain & Cognitive Sci., MIT, United States.

Humans have an astonishing ability to extract hidden information from the movements of others. For example, even with only limited kinematic information, humans can distinguish between biological and non-biological motion, identify the age and gender of a human demonstrator, and recognize what action a human demonstrator is performing. It is unknown, however, whether they can also estimate hidden mechanical properties of another's limbs simply by observing their motions. Read More

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http://dx.doi.org/10.1152/jn.00514.2018DOI Listing

Chemoselective Synthesis of N-Terminal Cysteinyl Thioesters via β,γ-C,S Thiol-Michael Addition.

Org Lett 2019 Apr 24. Epub 2019 Apr 24.

School of Chemistry and Trinity Biomedical Sciences Institute (TBSI) , Trinity College Dublin, The University of Dublin , Dublin 2 , Ireland.

Dehydroalanine (ΔAla) is a highly electrophilic residue that can react efficiently with sulfur nucleophiles to furnish cysteinyl analogues. Herein, we report an efficient synthesis of N-terminal cysteinyl thioesters, suitable for S, N-acyl transfer, based on β,γ-C,S thiol-Michael addition. Both ionic and radical-based methodologies were found to be efficient for this process. Read More

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http://dx.doi.org/10.1021/acs.orglett.9b01013DOI Listing

Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events.

JAMA Surg 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts.

Importance: The benefits of antimicrobial prophylaxis are limited to the first 24 hours postoperatively. Little is known about the harms associated with continuing antimicrobial prophylaxis after skin closure.

Objective: To characterize the association of type and duration of prophylaxis with surgical site infection (SSI), acute kidney injury (AKI), and Clostridium difficile infection. Read More

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http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamasurg.2019.0569DOI Listing
April 2019
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Efficacy of Integrated Exposure Therapy vs Integrated Coping Skills Therapy for Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A Randomized Clinical Trial.

JAMA Psychiatry 2019 Apr 24. Epub 2019 Apr 24.

VA San Diego Healthcare System, San Diego, California.

Importance: Co-occurrence of posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) is common and associated with psychiatric and functional problems. Understanding whether exposure therapy is tolerable and efficacious for treating PTSD and AUD is critical to ensure that best practice treatments are available.

Objective: To compare the efficacy of integrated (ie, targeting both PTSD and alcohol use) prolonged exposure (I-PE) therapy with present-centered integrated coping skills (I-CS) therapy, a more commonly available treatment, in reducing PTSD symptoms and alcohol use. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0638DOI Listing

Three-dimensional kinematic coupling in the knee during normal walking.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

Accurate joint kinematics play an important role in estimating joint kinetics in musculoskeletal simulations. Bi-planar fluoroscopic (BPF) systems have been introduced to measure skeletal kinematics with six degrees of freedom. The purpose of this study was to model knee kinematic coupling using knee kinematics during walking, as measured by the BPF system. Read More

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http://dx.doi.org/10.1115/1.4043562DOI Listing

Instability of Incompatible Bilayered Soft Tissues and the Role of Interface Conditions.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

Faculty of Aerospace Engineering, Technion|Israel Institute of Technology.

Mechanical stability analysis is instructive in explaining biological processes like morphogenesis, organogenesis, and pathogenesis of soft tissues. Consideration of the layered, residually-stressed structure of tissues, requires accounting for the joint effects of interface conditions and layer incompatibility. This paper is concerned with the influence of imposed rate (incremental) interface conditions (RICs) on critical loads in soft tissues, within the context of linear bifurcation analysis. Read More

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http://dx.doi.org/10.1115/1.4043560DOI Listing

Serum C-reactive protein relationship in high- versus low-virulence pathogens in the diagnosis of periprosthetic joint infection.

J Med Microbiol 2019 Apr 24. Epub 2019 Apr 24.

1 Department of Orthopaedic Surgery, Helios ENDO-Klinik Hamburg, Holstenstrasse 2, 22767 Hamburg, Germany.

Little is known about the relationship between the virulence of pathogens in periprosthetic joint infection (PJI) and C-reactive protein (CRP) levels. In this context, we assessed the performance of CRP for PJI. We collected the following data from 987 cases of total joint revision due to PJI and 386 cases of aseptic revision: age, gender, comorbidities, values for serum CRP, leukocytes, microbiology for preoperatively taken aspirations and at least 2 intraoperative biopsies, and presence or absence of a draining sinus. Read More

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http://dx.doi.org/10.1099/jmm.0.000958DOI Listing

Low rate of early vertical transmission of HIV supports the feasibility of effective implementation of the national PMTCT guidelines in routine practice of referral hospitals in Cameroon.

Paediatr Int Child Health 2019 Apr 24:1-8. Epub 2019 Apr 24.

l Assistance Publique des Hôpitaux de Paris, Pédiatrie Générale , Hôpital Robert Debré , Paris , France.

Background: Vertical (VT) transmission of HIV remains a public health concern in sub-Saharan Africa.

Objective: To investigate the VT rate and factors associated with transmission in routine practice in three referral hospitals in Cameroon.

Methods: All HIV-infected mothers who delivered in maternity wards or sought paediatric services during the first postnatal week from November 2007 to October 2010 were invited to participate in the ANRS-Pediacam cohort. Read More

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http://dx.doi.org/10.1080/20469047.2019.1585136DOI Listing

Automatic localization of anatomical regions in medical ultrasound images of rheumatoid arthritis using deep learning.

Proc Inst Mech Eng H 2019 Apr 24:954411919845747. Epub 2019 Apr 24.

3 Department of Biomedical Engineering, Vels Institute of Science, Technology and Advanced Studies, Chennai, India.

The pace of population aging is growing faster worldwide. The quality of life of the aging population is mostly affected by rheumatic diseases. With the increasing rate of rheumatoid arthritis in the aging population, technological advances in the field of automatic image processing and analysis have paved way for automatic detection and diagnosis of arthritis based on how the grade of the synovial region is designed. Read More

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http://dx.doi.org/10.1177/0954411919845747DOI Listing

What Can Be Done To Better Support Older Adults To Age Successfully In Their Homes And Communities?

Health Aff (Millwood) 2019 Apr 24:101377hlthaff201900203. Epub 2019 Apr 24.

Jennifer H. Molinsky is a senior research associate in the Joint Center for Housing Studies of Harvard University.

The rapid growth of the US population ages seventy-five and older in the coming years will increase the need for housing that accommodates mobility limitations and helps connect residents with supportive services and opportunities for socialization. While expanding the supply of housing with services such as those provided by independent and assisted living facilities is needed, so too are greater supports to allow older adults with disabilities to age successfully in their homes and communities. These include financial support for modifications to the home, the delivery of supportive services in the home by both family and paid caregivers, and the expansion of housing options in communities where older adults live. Read More

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http://dx.doi.org/10.1377/hlthaff.2019.00203DOI Listing

Porous Crystalline Olefin-Linked Covalent Organic Frameworks.

J Am Chem Soc 2019 Apr 23. Epub 2019 Apr 23.

Department of Chemistry , University of California-Berkeley ; Materials Sciences Division, Lawrence Berkeley National Laboratory; and Kavli Energy NanoSciences Institute, Berkeley , California 94720 , United States.

The first unsubstituted olefin-linked covalent organic framework, termed COF-701, was made by linking 2,4,6-trimethyl-1,3,5-triazine (TMT) and 4,4'-biphenyldicarbaldehyde (BPDA) through Aldol condensation. Formation of the unsubstituted olefin (-CH═CH-) linkage upon reticulation is confirmed by Fourier transform infrared (FT-IR) spectroscopy and solid-state C cross-polarization magic angle spinning (CP-MAS) NMR spectroscopy of the framework and of its C-isotope-labeled analogue. COF-701 is found to be porous (1715 m g) and to retain its composition and crystallinity under both strongly acidic and basic conditions. Read More

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http://dx.doi.org/10.1021/jacs.9b02848DOI Listing

The genome of cowpea (Vigna unguiculata [L.] Walp.).

Plant J 2019 Apr 24. Epub 2019 Apr 24.

Department of Botany and Plant Sciences, University of California, Riverside, CA, 92521, USA.

Cowpea (Vigna unguiculata [L.] Walp.) is a major crop for worldwide food and nutritional security, especially in sub-Saharan Africa, that is resilient to hot and drought-prone environments. Read More

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http://dx.doi.org/10.1111/tpj.14349DOI Listing

Knee joint function, walking ability, and quality of life within 6 weeks after total knee arthroplasty: a prospective cohort study.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

College of Nursing, Taipei Medical University, Taiwan.

Aims And Objectives: The aims of this study were to track changes in patients' knee function, walking ability, and quality of life (QOL) before and after knee arthroplasty surgery and explore factors that influenced these parameters.

Background: The number of days as an inpatient for those who undergo joint replacement operations has been greatly reduced in recent years. However, it remains unclear whether shortening the inpatient time has affected patients' recovery or their QOL. Read More

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http://dx.doi.org/10.1111/jocn.14888DOI Listing

Changes in prescription routines for treating hypothyroidism between 2001 and 2015 - an observational study of 929,684 primary care patients in Copenhagen.

Thyroid 2019 Apr 24. Epub 2019 Apr 24.

University of Copenhagen, The Research Unit for General Practice, Copenhagen, Denmark.

Background Increased public attention towards health and quality of life issues has led to more intensified screening for various medical conditions including hypothyroidism. A falling serum thyroid stimulating hormone (s-TSH) at initiation of levothyroxine (L-T4) treatment has been reported in the UK between 2001- 2009 indicating a falling TSH threshold which may lead to less benefit from therapy and possibly overtreatment. Objective To investigate changes in s-TSH threshold used by the general practitioners to initiate L-T4 therapy between 2001-2015 in Copenhagen. Read More

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http://dx.doi.org/10.1089/thy.2018.0539DOI Listing

Benzo-Fused Periacenes or Double Helicenes? Different Cyclodehydrogenation Pathways on Surface and in Solution.

J Am Chem Soc 2019 Apr 23. Epub 2019 Apr 23.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Joint International Research Laboratory of Carbon-Based Functional Materials and Devices , Soochow University , Suzhou 215123 , China.

Controlling the regioselectivity of C-H activation in unimolecular reactions is of great significance for the rational synthesis of functional graphene nanostructures, which are called nanographenes. Here, we demonstrate that the adsorption of tetranaphthyl- p-terphenyl precursors on metal surfaces can completely change the cyclodehydrogenation route and lead to obtaining planar benzo-fused perihexacenes rather than double [7]helicenes during solution synthesis. The course of the on-surface planarization reactions is monitored using scanning probe microscopy, which unambiguously reveals the formation of dibenzoperihexacenes and the structures of reaction intermediates. Read More

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http://dx.doi.org/10.1021/jacs.9b01267DOI Listing

[Kinematics and workspace analysis of a spherical exoskeleton parallel mechanism].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):213-222

School of Mechanical Engineering, North University of China, Taiyuan 030051, P.R.China.

Based on the biomechanical simulation curve of OpenSim, an open source software of biomechanical model, a spherical exoskeleton parallel mechanism with two degrees of freedom for hip joint is proposed in this paper for the rehabilitation therapy of patients with impaired leg motor function or elderly people with walking dysfunction. Firstly, the parallel mechanism is modeled and the position inverse solution of the parallel mechanism is obtained using inverse kinematics analysis. The velocity analysis expression of the mechanism is derived by deriving the inverse kinematics solution. Read More

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http://dx.doi.org/10.7507/1001-5515.201806024DOI Listing

[Progress of spatial epidemiology applied to prevention and control of schistosomiasis].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Feb;31(1):53-57

Department of Epidemiology, School of Public Health, Fudan University, Tropical Disease Research Center, Fudan University, Joint Laboratory of Tropical Disease Epidemiology, Shanghai 200032, China.

Schistosomiasis is one of the key diseases of surveillance and prevention in China. The elimination of schistosomiasis is of great significance to people's health and social economy. With the development of spatial epidemiology, progress has been made in the spatial distribution of schistosomiasis, the prediction of spatial and temporal trends, and analysis of the environmental factors. Read More

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http://dx.doi.org/10.16250/j.32.1374.2018304DOI Listing
February 2019

Maximal exercise and erythrocyte fatty-acid status: a lipidomics study.

Physiol Rep 2019 Apr;7(8):e14040

Experimental and Clinical Research Center (ECRC), A Joint Institution of the Charité Medical Faculty and Max Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.

Omega-3 fatty acids have long been ascribed a positive cardiovascular function. However, the plasma measurements invariably ignore 40% of the blood specimen, cells that engage in continuous exchange with their environment. In our study, we included all components of the circulating blood. Read More

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http://dx.doi.org/10.14814/phy2.14040DOI Listing

Identification of microRNA transcriptome reveals that miR-100 is involved in the renewal of porcine intestinal epithelial cells.

Sci China Life Sci 2019 Apr 23. Epub 2019 Apr 23.

Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, School of Life Sciences, Hunan Normal University, Changsha, 410081, China.

MicroRNAs play important roles in various cellular processes, including differentiation, proliferation and survival. Using a pig model, this study sought to identify the miRNAs responsible for crypt-villus axis renewal of the small intestinal epithelium. Compared to the villus upper cells, there were 15 up-regulated and 41 down-regulated miRNAs in the crypt cells of the jejunum. Read More

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http://link.springer.com/10.1007/s11427-018-9338-9
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http://dx.doi.org/10.1007/s11427-018-9338-9DOI Listing
April 2019
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Degradation of antifungal anthraquinone compounds is a probable physiological role of DyP secreted by Bjerkandera adusta.

AMB Express 2019 Apr 23;9(1):56. Epub 2019 Apr 23.

Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, 2-8-1 Mejirodai, Bunkyo-ku, Tokyo, 112-8681, Japan.

Alizarin is an anti-fungal compound produced by the plant, Rubia tinctorum. The parasitic fungus Bjerkandera adusta Dec 1 was cultured in potato dextrose (PD) medium with or without alizarin. Alizarin was a good substrate for the dye-decolorizing peroxidase (DyP) from B. Read More

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http://dx.doi.org/10.1186/s13568-019-0779-4DOI Listing

Dopaminergic Agents in Rheumatoid Arthritis.

Authors:
Silvia Capellino

J Neuroimmune Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Junior Group Neuroimmunology, Department of Immunology, IfADo - Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.

Clinical evidences suggest a causal relationship between rheumatoid arthritis (RA) and the dopaminergic system, and several studies described an alteration of the disease in patients treated with dopaminergic agents. Despite these interesting results, potential direct effects of dopamine on RA have not been intensively considered until the last decade. Recent studies confirm a direct effect of dopamine on the systemic immune response as well as on bone remodeling and on joint inflammation, both in humans and in different animal models of arthritis. Read More

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http://dx.doi.org/10.1007/s11481-019-09850-5DOI Listing

Radiomics analysis of multiparametric MRI for the preoperative evaluation of pathological grade in bladder cancer tumors.

Eur Radiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.

Objectives: To develop and validate an MRI-based radiomics strategy for the preoperative estimation of pathological grade in bladder cancer (BCa) tumors.

Methods: A primary cohort of 70 patients (31 high-grade BCa and 39 low-grade BCa) with BCa were retrospectively enrolled. Three sets of radiomics features were separately extracted from tumor volumes on T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) maps. Read More

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http://dx.doi.org/10.1007/s00330-019-06222-8DOI Listing

The medicolegal, psycho-criminological, and epidemiological reality of intimate partner and non-intimate partner femicide in North-West Italy: looking backwards to see forwards.

Int J Legal Med 2019 Apr 23. Epub 2019 Apr 23.

Laboratory of Criminalistic Sciences "Carlo Torre", Department of Public Health and Pediatrics, University of Turin, Corso Galileo Galilei, 22, 10126, Turin, Italy.

This paper addresses femicide in Italy. The assumption is that femicide is not a discrete act of killing a woman. It is assumed that depending on the types of relationship between the victim and the perpetrator (e. Read More

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http://dx.doi.org/10.1007/s00414-019-02061-wDOI Listing

Genetic mapping of a major QTL promoting homoeologous chromosome pairing in a wheat landrace.

Theor Appl Genet 2019 Apr 23. Epub 2019 Apr 23.

Triticeae Research Institute, Sichuan Agricultural University, Chengdu Campus, Wenjiang, 611130, Sichuan, China.

Key Message: Common wheat landrace Kaixian-luohanmai carries a gene(s) that promotes homoeologous chromosome pairing. A major QTL responsible for this effect was mapped to chromosome arm 3AL. Polyhaploid hybrids of a Chinese common wheat landrace Kaixian-luohanmai (KL) and related species show increased levels of chromosome pairing. Read More

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http://link.springer.com/10.1007/s00122-019-03344-x
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http://dx.doi.org/10.1007/s00122-019-03344-xDOI Listing

Aseptic loosening of an APTIS distal radioulnar joint arthroplasty - Case report.

Trauma Case Rep 2019 Jun 15;21:100196. Epub 2019 Apr 15.

University of Kentucky (Orthopaedic Surgery & Sports Medicine), Lexington, KY 40536, United States of America.

Dysfunction of the distal radioulnar joint can cause significant pain and instability. The self-stabilizing APTIS distal radioulnar joint prosthesis is used as a solution for severe distal radioulnar joint pathologies. We present a case of a 60-year-old male, who received an APTIS distal radioulnar joint prosthesis which resulted in aseptic loosening within five years of the initial implantation. Read More

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http://dx.doi.org/10.1016/j.tcr.2019.100196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465771PMC

Post-traumatic acetabular dysplasia following pelvic fracture malunion associated with an acetabular labral tear: A case report and literature review.

Trauma Case Rep 2019 Jun 17;21:100195. Epub 2019 Apr 17.

Department of Orthopaedics, Thammasat University, Pathum Thani, Thailand.

Residual acetabular dysplasia has been reported to be the pre-arthritic condition of the hip due to abnormal joint force during the normal physiological load that leads to an acetabular labral tear. This report shows the sequalae of a malunited acetabulo-pelvic fracture that resulted in hip dysplastic morphology and may be the cause of subsequent acetabular labral tears. The under-coverage or the dysplastic alignment of the pelvis after treatment of the fracture should be of concern for a secondary acetabular labral tear of the hip. Read More

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http://dx.doi.org/10.1016/j.tcr.2019.100195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475764PMC

The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases.

Biomed Res Int 2019 20;2019:8086257. Epub 2019 Mar 20.

Department of Rheumatology and immunology, Peking University International Hospital, Beijing 102206, China.

Αlpha-lipoic acid is a naturally occurring antioxidant in human body and has been widely used as an antioxidant clinically. Accumulating evidences suggested that -lipoic acid might have immunomodulatory effects on both adaptive and innate immune systems. This review focuses on the evidences and potential targets involved in the immunomodulatory effects of -lipoic acid. Read More

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http://dx.doi.org/10.1155/2019/8086257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446120PMC

NNS-Conjugated Chitosan Mediated IGF-1 and miR-140 Overexpression in Articular Chondrocytes Improves Cartilage Repair.

Biomed Res Int 2019 21;2019:2761241. Epub 2019 Mar 21.

Institute of Nanomedicine Technology, Department of Laboratory Medicine, Weifang Medical University, Weifang, Shandong 261053, China.

The aim of the present study was to investigate the effects of phosphorylatable nucleus localization signal linked nucleic kinase substrate short peptide (NNS)-conjugated chitosan (NNS-CS) mediated miR-140 and IGF-1 in both rabbit chondrocytes and cartilage defects model. NNS-CS was combined with pBudCE4.1-IGF-1, pBudCE4. Read More

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http://dx.doi.org/10.1155/2019/2761241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448336PMC

Meniscus Subluxation Retensioning: "Autotransplant".

Arthrosc Tech 2019 Mar 25;8(3):e335-e341. Epub 2019 Feb 25.

Clínica do Dragão, Espregueira-Mendes Sports Centre-FIFA Medical Centre of Excellence, Porto, Portugal.

Knee osteoarthritis (OA) is a common condition in the older population and is characterized by several articular dysfunctions with consequent anatomic abnormalities including osteochondral degenerative changes and meniscal extrusion. Meniscal damage with extrusion is one of the strongest identified risk factors for the development and progression of knee OA and represents an important factor in the long-term health of the joint. Meniscal extrusion can alter normal knee biomechanics and dramatically inhibit meniscal function. Read More

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http://dx.doi.org/10.1016/j.eats.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475648PMC

Frequency, Awareness, and Symptoms of Chikungunya Among Patients in a Tertiary Care Hospital of Karachi: A Cross-Sectional Study.

Cureus 2019 Feb 12;11(2):e4054. Epub 2019 Feb 12.

Internal Medicine, Dow University of Health Sciences (DUHS), Karachi, PAK.

Background  Chikungunya fever (CHIKF) is an infectious illness spread by the bite of mosquitoes and caused by an arbovirus known as Chikungunya virus (CHIKV). This disease has become an epidemic in Karachi and various other cities of Pakistan, affecting a large population, especially those from poor, socioeconomically underdeveloped areas. It is proving to be a severe and alarming cause of debility due to its prolonged detrimental effects on the joints. Read More

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http://dx.doi.org/10.7759/cureus.4054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464461PMC
February 2019

Prevalence of hypertension and blood pressure profile amongst urban-dwelling adults in Nigeria: a comparative analysis based on recent guideline recommendations.

Clin Hypertens 2019 15;25. Epub 2019 Apr 15.

2Department of Medicine, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria.

Background: Hypertension is the major risk factor for cardiovascular diseases and prevalence rates are critical to understanding the burden and envisaging health service requirements and resource allocation. We aimed to provide an update of the current prevalence of hypertension and blood pressure profiles of adults in urban Nigeria.

Methods: Cross sectional population-based survey in Lagos, Nigeria. Read More

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http://dx.doi.org/10.1186/s40885-019-0112-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463661PMC

Comparative Evaluation of Ga-Citrate PET/CT and F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats.

Contrast Media Mol Imaging 2019 19;2019:2353658. Epub 2019 Mar 19.

Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. Read More

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http://dx.doi.org/10.1155/2019/2353658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444231PMC

Rat bite fever on Vancouver Island: 2010-2016.

Can Commun Dis Rep 2018 Sep 6;44(9):215-219. Epub 2018 Sep 6.

University of British Columbia, Vancouver, BC.

Background: Rat bite fever (RBF) is a rare bacterial zoonotic infection caused by and which are found naturally in rodent respiratory tracts. Recently, multiple cases of RBF were observed on Vancouver Island, British Columbia.

Objective: To conduct a case series analysis of cases of RBF on Vancouver Island between 2010 and 2016 to characterize the epidemiology, presentation, microbiology and treatment of RBF. Read More

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http://dx.doi.org/10.14745/ccdr.v44i09a05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449109PMC
September 2018

A high-intensity cluster of infection around Mbita causeway, western Kenya: a confirmatory cross-sectional survey.

Trop Med Health 2019 15;47:26. Epub 2019 Apr 15.

1Leading program, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

In Kenya, communities residing along the shores and islands of Lake Victoria bear a substantial burden of schistosomiasis. Although there is a school-based deworming program in place, the transmission of varies even at a fine scale. Given the focal nature of schistosomes' transmission, we aim to identify areas with high intensity of infection in Mbita, Homabay County, western Kenya, for prioritized integrated control measures. Read More

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http://dx.doi.org/10.1186/s41182-019-0152-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463626PMC

A 2-year follow-up of isolated Medial Patellofemoral Ligament Reconstruction by using soft suture anchor and adjustable cortical fixation system.

J Orthop 2019 Jul-Aug;16(4):356-360. Epub 2019 Apr 13.

Department of Orthopaedics Surgery (Ohashi), School of Medicine, Toho University, Japan.

Purpose: Numerous surgical techniques and fixation methods have been described in medial patellofemoral ligament (MPFL) reconstruction such as choice of graft, graft fixation method of patella/femur and initial tension. We describe short term clinical results of MPFL reconstruction by using soft suture anchor and adjustable cortical fixation system.

Methods: Twenty-four patients who underwent isolated MPFL reconstruction by using soft suture anchor and adjustable cortical fixation system were included in this study. Read More

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http://dx.doi.org/10.1016/j.jor.2019.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475767PMC

Publisher Correction: Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling.

Nat Struct Mol Biol 2019 Apr 23. Epub 2019 Apr 23.

MOE Key Laboratory of Protein Science, Tsinghua University, Beijing, China.

In the version of this article initially published, the date of publication (13 March 2019) was incorrect. The correct date is 14 March 2019. The error has been corrected in the HTML and PDF versions of the article. Read More

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http://dx.doi.org/10.1038/s41594-019-0229-7DOI Listing

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy.

Nat Biomed Eng 2018 Nov 29;2(11):831-840. Epub 2018 Oct 29.

Department of Bioengineering, University of California, Los Angeles, CA, USA.

Patients with acute myeloid leukaemia who relapse following therapy have few treatment options and face poor outcomes. Immune checkpoint inhibition, for example, by antibody-mediated programmed death-1 (PD-1) blockade, is a potent therapeutic modality that improves treatment outcomes in acute myeloid leukaemia. Here, we show that systemically delivered blood platelets decorated with anti-PD-1 antibodies (aPD-1) and conjugated to haematopoietic stem cells (HSCs) suppress the growth and recurrence of leukaemia in mice. Read More

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http://dx.doi.org/10.1038/s41551-018-0310-2DOI Listing
November 2018

Complex effects of atmospheric parameters on acute cardiovascular diseases and major cardiovascular risk factors: data from the Cardiometeorology study.

Sci Rep 2019 Apr 23;9(1):6358. Epub 2019 Apr 23.

Semmelweis University, Department of Vascular Surgery, 68. Városmajor street, Budapest, 1122, Hungary.

Several studies have examined the cardiovascular effects of atmospheric parameters as separate factors; however, few have investigated atmospheric parameters' joint effects. We aim to explore the joint effects of atmospheric parameters on acute cardiovascular diseases (ACVDs) and on major cardiovascular risk factors (CRFs). We correlated all ACVD admissions with major CRFs and local atmospheric conditions during a 5-year study period. Read More

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http://dx.doi.org/10.1038/s41598-019-42830-6DOI Listing

Dramatic differences in carbon dioxide adsorption and initial steps of reduction between silver and copper.

Nat Commun 2019 Apr 23;10(1):1875. Epub 2019 Apr 23.

Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.

Converting carbon dioxide (CO) into liquid fuels and synthesis gas is a world-wide priority. But there is no experimental information on the initial atomic level events for CO electroreduction on the metal catalysts to provide the basis for developing improved catalysts. Here we combine ambient pressure X-ray photoelectron spectroscopy with quantum mechanics to examine the processes as Ag is exposed to CO both alone and in the presence of HO at 298 K. Read More

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http://dx.doi.org/10.1038/s41467-019-09846-yDOI Listing

The future of Southeast Asia's forests.

Nat Commun 2019 Apr 23;10(1):1829. Epub 2019 Apr 23.

University of Tsukuba, Tsukuba, Japan.

While Southeast Asia's forests play important roles in biodiversity conservation and global carbon (C) balance, the region is also a deforestation hotspot. Here, we consider the five shared socioeconomic pathways (SSPs) to portray a range of plausible futures for the region's forests, employing a state-of-the-art land change modelling procedure and remotely sensed data. We find that by 2050 under the worst-case scenario, SSP 3 (regional rivalry/a rocky road), the region's forests would shrink by 5. Read More

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http://dx.doi.org/10.1038/s41467-019-09646-4DOI Listing

Mesothelin Expression Is a Predictive Factor for Peritoneal Recurrence in Curatively Resected Stage III Gastric Cancer.

Oncologist 2019 Apr 23. Epub 2019 Apr 23.

Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea

Background: Mesothelin is overexpressed in many solid tumors, and recent studies have shown that mesothelin expression is associated with poor outcomes in several malignant tumors and may play a role in cancer progression. Clinical trials of mesothelin-targeted immunotherapies are currently under way, but the correlation between mesothelin expression and gastric cancer prognosis is still unclear.

Subjects, Materials, And Methods: Mesothelin expression in tumor cells was evaluated immunohistochemically in 958 patients with advanced gastric cancer and interpreted according to the intensity and extent of staining. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0896DOI Listing

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.

EMBO Mol Med 2019 Apr 23. Epub 2019 Apr 23.

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore City, Singapore

Currently, there are no commercially available live-attenuated vaccines against chikungunya virus (CHIKV). Here, CHIKVs with mutations in non-structural proteins (nsPs) were investigated for their suitability as attenuated CHIKV vaccines. R532H mutation in nsP1 caused reduced infectivity in mouse tail fibroblasts but an enhanced type-I IFN response compared to WT-CHIKV Adult mice infected with this nsP-mutant exhibited a mild joint phenotype with low-level viremia that rapidly cleared. Read More

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http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
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http://dx.doi.org/10.15252/emmm.201810092DOI Listing

Bi-allelic loss of function variants of causes a spectrum of malformation of spine and rib including congenital scoliosis and spondylocostal dysostosis.

J Med Genet 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan

Background: Congenital scoliosis (CS) is a common vertebral malformation. Spondylocostal dysostosis (SCD) is a rare skeletal dysplasia characterised by multiple vertebral malformations and rib anomalies. In a previous study, a compound heterozygosity for a null mutation and a risk haplotype composed by three single-nucleotide polymorphisms in have been reported as a disease-causing model of CS. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105920DOI Listing

Diabetic muscle infarction: rare complication with a distinct clinical manifestation.

BMJ Case Rep 2019 Apr 23;12(4). Epub 2019 Apr 23.

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Diabetic muscle infarction is an unusual condition with distinctive clinical characteristics seen in patients with prolonged and uncontrolled diabetes. Clinical findings and imaging study are unique and challenging. Patients usually present with acute unilateral severe muscular pain and swelling, particularly in the lower extremities. Read More

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http://dx.doi.org/10.1136/bcr-2018-228480DOI Listing
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